Clinical Impact of Prescribed Doses of Nutrients for Patients Exclusively Receiving Total Parenteral Nutrition in Japanese Hospitals: A Retrospective Cohort Study.

BACKGROUND: In patients receiving total parenteral nutrition, the association between nutritional achievement in accordance with the nutritional guidelines and outcomes remains unclear. Our purpose was to assess the association between nutritional achievement and clinical outcomes, including in-hospital mortality, activity of daily living (ADL), and readmission.

METHODS: In this retrospective cohort study, data were extracted from an inpatient medical claims database at 380 acute care hospitals. This study included patients who underwent central venous catheter insertion between January 2009 and December 2018. Patients were classified into three groups: 1) target-not-achieved; 2) target-partially-achieved; and 3) target-achieved. The target doses of energy, amino acids, and fat were defined as ≥20 kcal/kg/day, ≥1.0 g/kg/day, and ≥2.5 g/day, respectively. To examine the effect of nutritional achievement on outcomes, multivariable logistic regression analysis was performed.

RESULTS: A total of 54,687 patients were included, of these, 21,383 patients were in the target-not-achieved group, 29,610 patients were in the target-partially-achieved group, and 3,694 patients were in the target-achieved group. The adjusted OR (95% CI) for in-hospital mortality was 0.69 (0.66-0.72) in the target-partially-achieved group and 0.47 (0.43-0.52) in the target-achieved group with reference to the target-not-achieved group. The adjusted ORs for deteriorated ADL was 0.93 (0.85-1.01) in the target-partially-achieved group and 0.77 (0.65-0.92) in the target-achieved group with reference to the target-not-achieved group. Readmission was not associated with nutrition achievement.

CONCLUSION: In-hospital mortality was lower and deteriorated ADL was suppressed in patients whose TPN management was in accordance with the nutritional guidelines. This article is protected by copyright. All rights reserved.