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Alexandra D Frolkis, Isabelle A Vallerand, Scott B Patten, Gilaad G Kaplan
No abstract text is available yet for this article.
March 20, 2019: Gut
Elisabeth Hessmann, Volker Ellenrieder
No abstract text is available yet for this article.
March 19, 2019: Gut
Francisco Javier Cubero, Maria Luz Martinez-Chantar
No abstract text is available yet for this article.
March 18, 2019: Gut
Philipp Kasper, Tobias Goeser, Dirk Nierhoff
No abstract text is available yet for this article.
March 16, 2019: Gut
Enrico N De Toni, Anne Schlesinger-Raab, Martin Fuchs, Wolfgang Schepp, Ursula Ehmer, Fabian Geisler, Jens Ricke, Philipp Paprottka, Helmut Friess, Jens Werner, Alexander L Gerbes, Julia Mayerle, Jutta Engel
OBJECTIVE: Hepatocellular carcinoma (HCC) is a major cause of death worldwide and its incidence is expected to increase globally. Aim of this study was to assess whether the implementation of screening policies and the improvement of treatment options translated into a real-world survival benefit in HCC patients. DESIGN: 4078 patients diagnosed with HCC between 1998 and 2016 from the Munich Cancer Registry were analysed. Tumour characteristics and outcome were analysed by time period and according to age and presence of metastases at diagnosis...
March 16, 2019: Gut
Lijun Liao, Kai Markus Schneider, Eric J C Galvez, Mick Frissen, Hanns-Ulrich Marschall, Huan Su, Maximilian Hatting, Annika Wahlström, Johannes Haybaeck, Philip Puchas, Antje Mohs, Jin Peng, Ina Bergheim, Anika Nier, Julia Hennings, Johanna Reißing, Henning W Zimmermann, Thomas Longerich, Till Strowig, Christian Liedtke, Francisco J Cubero, Christian Trautwein
OBJECTIVE: There is a striking association between human cholestatic liver disease (CLD) and inflammatory bowel disease. However, the functional implications for intestinal microbiota and inflammasome-mediated innate immune response in CLD remain elusive. Here we investigated the functional role of gut-liver crosstalk for CLD in the murine Mdr2 knockout (Mdr2-/- ) model resembling human primary sclerosing cholangitis (PSC). DESIGN: Male Mdr2 -/- , Mdr2-/- crossed with hepatocyte-specific deletion of caspase-8 ( Mdr2-/- /Casp8∆hepa ) and wild-type (WT) control mice were housed for 8 or 52 weeks, respectively, to characterise the impact of Mdr2 deletion on liver and gut including bile acid and microbiota profiling...
March 14, 2019: Gut
Ann-Marie Baker, Calum Gabbutt, Marc J Williams, Biancastella Cereser, Noor Jawad, Manuel Rodriguez-Justo, Marnix Jansen, Chris P Barnes, Benjamin D Simons, Stuart Ac McDonald, Trevor A Graham, Nicholas A Wright
OBJECTIVE: The crypt population in the human intestine is dynamic: crypts can divide to produce two new daughter crypts through a process termed crypt fission, but whether this is balanced by a second process to remove crypts, as recently shown in mouse models, is uncertain. We examined whether crypt fusion (the process of two neighbouring crypts fusing into a single daughter crypt) occurs in the human colon. DESIGN: We used somatic alterations in the gene cytochrome c oxidase (CCO) as lineage tracing markers to assess the clonality of bifurcating colon crypts (n=309 bifurcating crypts from 13 patients)...
March 14, 2019: Gut
Sravanthi Parasa, Madhav Desai, Anusha Vittal, Viveksandeep T Chandrasekar, Asad Pervez, Kevin F Kennedy, Neil Gupta, Nicholas J Shaheen, Prateek Sharma
BACKGROUND: Biopsies are obtained to confirm intestinal metaplasia and rule out prevalent dysplasia and cancer when Barrett's oesophagus (BE) is detected at index upper endoscopy (oesophagogastroduodenoscopy [EGD]). AIM: The purpose of this systematic review was to obtain summary estimates of the prevalence of high-grade dysplasia (HGD) and oesophageal adenocarcinoma (EAC) associated with BE during index EGD for chronic GERD symptoms, defined as neoplasia detection rate (NDR) which could be used as a quality measure...
March 14, 2019: Gut
Rogier Aäron Gaiser, Asif Halimi, Hassan Alkharaan, Liyan Lu, Haleh Davanian, Katie Healy, Luisa W Hugerth, Zeeshan Ateeb, Roberto Valente, Carlos Fernández Moro, Marco Del Chiaro, Margaret Sällberg Chen
OBJECTIVES: Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can progress to invasive pancreatic cancer. Associations between oncogenesis and oral microbiome alterations have been reported. This study aims to investigate a potential intracystic pancreatic microbiome in a pancreatic cystic neoplasm (PCN) surgery patient cohort. DESIGN: Paired cyst fluid and plasma were collected at pancreatic surgery from patients with suspected PCN (n=105)...
March 14, 2019: Gut
Jin-Huan Lin, Arnaud Boulling, Emmanuelle Masson, David N Cooper, Zhao-Shen Li, Claude Férec, Zhuan Liao, Jian-Min Chen
No abstract text is available yet for this article.
March 12, 2019: Gut
Lianlian Wu, Jun Zhang, Wei Zhou, Ping An, Lei Shen, Jun Liu, Xiaoda Jiang, Xu Huang, Ganggang Mu, Xinyue Wan, Xiaoguang Lv, Juan Gao, Ning Cui, Shan Hu, Yiyun Chen, Xiao Hu, Jiangjie Li, Di Chen, Dexin Gong, Xinqi He, Qianshan Ding, Xiaoyun Zhu, Suqin Li, Xiao Wei, Xia Li, Xuemei Wang, Jie Zhou, Mengjiao Zhang, Hong Gang Yu
OBJECTIVE: Esophagogastroduodenoscopy (EGD) is the pivotal procedure in the diagnosis of upper gastrointestinal lesions. However, there are significant variations in EGD performance among endoscopists, impairing the discovery rate of gastric cancers and precursor lesions. The aim of this study was to construct a real-time quality improving system, WISENSE, to monitor blind spots, time the procedure and automatically generate photodocumentation during EGD and thus raise the quality of everyday endoscopy...
March 11, 2019: Gut
Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert O'Neill, Fergus Noble, Timothy J Underwood, D Paul Harkin, Manuel Salto-Tellez, Rebecca C Fitzgerald, Richard D Kennedy
OBJECTIVE: Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC. DESIGN: Transcriptional profiling of 273 formalin-fixed paraffin-embedded prechemotherapy endoscopic OAC biopsies was performed. All patients were treated with platinum-based neoadjuvant chemotherapy and resection between 2003 and 2014 at four centres in the Oesophageal Cancer Clinical and Molecular Stratification consortium...
March 9, 2019: Gut
Pin Wang, Yunshan Wang, Sasha A Langley, Yan-Xia Zhou, Kuang-Yu Jen, Qi Sun, Colin Brislawn, Carolina M Rojas, Kimberly L Wahl, Ting Wang, Xiangshan Fan, Janet K Jansson, Susan E Celniker, Xiaoping Zou, David W Threadgill, Antoine M Snijders, Jian-Hua Mao
OBJECTIVE: The Collaborative Cross (CC) is a mouse population model with diverse and reproducible genetic backgrounds used to identify novel disease models and genes that contribute to human disease. Since spontaneous tumour susceptibility in CC mice remains unexplored, we assessed tumour incidence and spectrum. DESIGN: We monitored 293 mice from 18 CC strains for tumour development. Genetic association analysis and RNA sequencing were used to identify susceptibility loci and candidate genes...
March 6, 2019: Gut
Tao Zuo, Xiao-Juan Lu, Yu Zhang, Chun Pan Cheung, Siu Lam, Fen Zhang, Whitney Tang, Jessica Y L Ching, Risheng Zhao, Paul K S Chan, Joseph J Y Sung, Jun Yu, Francis K L Chan, Qian Cao, Jian-Qiu Sheng, Siew C Ng
OBJECTIVE: The pathogenesis of UC relates to gut microbiota dysbiosis. We postulate that alterations in the viral community populating the intestinal mucosa play an important role in UC pathogenesis. This study aims to characterise the mucosal virome and their functions in health and UC. DESIGN: Deep metagenomics sequencing of virus-like particle preparations and bacterial 16S rRNA sequencing were performed on the rectal mucosa of 167 subjects from three different geographical regions in China (UC=91; healthy controls=76)...
March 6, 2019: Gut
Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
OBJECTIVE: Hepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of liver cancer. Efficient therapeutic approaches against HDV are absent. DESIGN: Here, we combined an RNAi loss-of-function and small molecule screen to uncover host-dependency factors for HDV infection. RESULTS: Functional screening unravelled the hypoxia-inducible factor (HIF)-signalling and insulin-resistance pathways, RNA polymerase II, glycosaminoglycan biosynthesis and the pyrimidine metabolism as virus-hepatocyte dependency networks...
March 4, 2019: Gut
Shu-Heng Jiang, Li-Li Zhu, Man Zhang, Rong-Kun Li, Qin Yang, Jiang-Yu Yan, Ce Zhang, Jian-Yu Yang, Fang-Yuan Dong, Miao Dai, Li-Peng Hu, Jun Li, Qing Li, Ya-Hui Wang, Xiao-Mei Yang, Yan-Li Zhang, Hui-Zhen Nie, Lei Zhu, Xue-Li Zhang, Guang-Ang Tian, Xiao-Xin Zhang, Xiao-Yan Cao, Ling-Ye Tao, Shan Huang, Yong-Sheng Jiang, Rong Hua, Kathy Qian Luo, Jian-Ren Gu, Yong-Wei Sun, Shangwei Hou, Zhi-Gang Zhang
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death worldwide. Neurotransmitter-initiated signalling pathway is profoundly implicated in tumour initiation and progression. Here, we investigated whether dysregulated neurotransmitter receptors play a role during pancreatic tumourigenesis. METHODS: The Cancer Genome Atlas and Gene Expression Omnibus datasets were used to identify differentially expressed neurotransmitter receptors...
March 2, 2019: Gut
Rinse K Weersma, Miles Parkes
No abstract text is available yet for this article.
March 2, 2019: Gut
(no author information available yet)
No abstract text is available yet for this article.
March 2, 2019: Gut
Pu Wang, Tyler M Berzin, Jeremy Romek Glissen Brown, Shishira Bharadwaj, Aymeric Becq, Xun Xiao, Peixi Liu, Liangping Li, Yan Song, Di Zhang, Yi Li, Guangre Xu, Mengtian Tu, Xiaogang Liu
OBJECTIVE: The effect of colonoscopy on colorectal cancer mortality is limited by several factors, among them a certain miss rate, leading to limited adenoma detection rates (ADRs). We investigated the effect of an automatic polyp detection system based on deep learning on polyp detection rate and ADR. DESIGN: In an open, non-blinded trial, consecutive patients were prospectively randomised to undergo diagnostic colonoscopy with or without assistance of a real-time automatic polyp detection system providing a simultaneous visual notice and sound alarm on polyp detection...
February 27, 2019: Gut
Shiv Singh, Marie Christin Hasselluhn, Albrecht Neesse
No abstract text is available yet for this article.
February 27, 2019: Gut
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