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Phey Shen Lee, Laura Jopson, Stephanie J Needham, Christopher G Mountford, Nick P Thompson
No abstract text is available yet for this article.
November 8, 2019: Gut
#2
Christina Heichler, Kristina Scheibe, Anabel Schmied, Carol I Geppert, Benjamin Schmid, Stefan Wirtz, Oana-Maria Thoma, Viktoria Kramer, Maximilian J Waldner, Christian Büttner, Henner Farin, Marina Pešić, Ferdinand Knieling, Susanne Merkel, Anika Grüneboom, Matthias Gunzer, Robert Grützmann, Stefan Rose-John, Sergei Koralov, George Kollias, Michael Vieth, Arndt Hartmann, Florian Greten, Markus F Neurath, Clemens Neufert
OBJECTIVE: Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood. DESIGN: We quantified phosphorylation of STAT3 (pSTAT3) expression in CAFs of human colon cancer tissue using a tissue microarray (TMA) of 375 patients, immunofluorescence staining and digital pathology. To investigate the functional role of CAFs in CRC, we took advantage of two murine models of colorectal neoplasia and advanced imaging technologies...
November 4, 2019: Gut
#3
Michael Goggins, Kasper Alexander Overbeek, Randall Brand, Sapna Syngal, Marco Del Chiaro, Detlef K Bartsch, Claudio Bassi, Alfredo Carrato, James Farrell, Elliot Fishman, Paul Fockens, Thomas M Gress, Jeanin E van Hooft, R H Hruban, Fay Kastrinos, Allison Klein, Anne Marie Lennon, Aimee Lucas, Walter Park, Anil Rustgi, Diane Simeone, Elena Stoffel, Hans F A Vasen, Djuna L Cahen, Marcia Irene Canto, Marco Bruno
BACKGROUND AND AIM: The International Cancer of the Pancreas Screening Consortium met in 2018 to update its consensus recommendations for the management of individuals with increased risk of pancreatic cancer based on family history or germline mutation status (high-risk individuals). METHODS: A modified Delphi approach was employed to reach consensus among a multidisciplinary group of experts who voted on consensus statements. Consensus was considered reached if ≥75% agreed or disagreed...
October 31, 2019: Gut
#4
Sung Won Lee, Jung Hyun Kwon, Hae Lim Lee, Sun Hong Yoo, Hee Chul Nam, Pil Soo Sung, Soon Woo Nam, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Nam Ik Han, Jeong Won Jang
OBJECTIVE: The use of tenofovir (TDF) and entecavir (ETV) in patients with chronic hepatitis B (CHB) has led to a decrease in the incidence of hepatocellular carcinoma (HCC) and liver-related events. However, whether there is a difference between the two agents in the extent of improving such outcomes has not been clarified thus far. Therefore, we aimed to compare TDF and ETV on the risk of HCC and mortality. DESIGN: A total of 7015 consecutive patients with CHB who were treated with TDF or ETV between February 2007 and January 2018 at the liver units of the Catholic University of Korea were screened for study eligibility and 3022 patients were finally analysed...
October 31, 2019: Gut
#5
LETTER
Yuk Lung Wong, Lars Hummitzsch, Ingmar Lautenschläger, Karina Zitta, Thilo Wedel, François Cossais, Clemens Schafmayer, Thomas Becker, Rouven Berndt, Matthias Gruenewald, Norbert Weiler, Markus Steinfath, Martin Albrecht
No abstract text is available yet for this article.
October 30, 2019: Gut
#6
LETTER
Malte Christoph Rühlemann, Miriam Emmy Leni Solovjeva, Roman Zenouzi, Timur Liwinski, Martin Kummen, Wolfgang Lieb, Johannes Roksund Hov, Christoph Schramm, Andre Franke, Corinna Bang
No abstract text is available yet for this article.
October 25, 2019: Gut
#7
LETTER
Yongpeng Chen, Xiao-Yu Lin
No abstract text is available yet for this article.
October 25, 2019: Gut
#8
Zhuwan Lyu, Qi Miao, Pan Jiang, Xiao Xiao, Xiaoyu Chen, Qixia Wang, Xiong Ma
No abstract text is available yet for this article.
October 18, 2019: Gut
#9
Ernst J Kuipers, Esmée J Grobbee
No abstract text is available yet for this article.
October 15, 2019: Gut
#10
Beatrice Foglia, Maurizio Parola
No abstract text is available yet for this article.
October 15, 2019: Gut
#11
Cesare Hassan, Michael B Wallace, Prateek Sharma, Roberta Maselli, Vincenzo Craviotto, Marco Spadaccini, Alessandro Repici
No abstract text is available yet for this article.
October 15, 2019: Gut
#12
LETTER
Enrico N De Toni
No abstract text is available yet for this article.
October 14, 2019: Gut
#13
Chen Liang, Si Shi, Yi Qin, Qingcai Meng, Jie Hua, Qiangshen Hu, Shunrong Ji, Bo Zhang, Jin Xu, Xian-Jun Yu
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive type of GI tumour, and it possesses deregulated cellular energetics. Although recent advances in PDAC biology have led to the discovery of recurrent genetic mutations in Kras , TP53 and SMAD4 , which are related to this disease, clinical application of the molecular phenotype of PDAC remains challenging. DESIGN: We combined molecular imaging technology (positron emission tomography/CT) and immunohistochemistry to evaluate the correlation between the maximum standardised uptake value and SMAD4 expression and examined the effect of SMAD4 on glycolysis through in vitro and in vivo experiments...
October 14, 2019: Gut
#14
LETTER
Marnix Jansen, Matthew Banks
No abstract text is available yet for this article.
October 14, 2019: Gut
#15
Siew C Ng, Michael A Kamm, Yun Kit Yeoh, Paul K S Chan, Tao Zuo, Whitney Tang, Ajit Sood, Akira Andoh, Naoki Ohmiya, Yongjian Zhou, Choon Jin Ooi, Varocha Mahachai, Chun-Ying Wu, Faming Zhang, Kentaro Sugano, Francis K L Chan
OBJECTIVE: The underlying microbial basis, predictors of therapeutic outcome and active constituent(s) of faecal microbiota transplantation (FMT) mediating benefit remain unknown. An international panel of experts presented key elements that will shape forthcoming FMT research and practice. DESIGN: Systematic search was performed, FMT literature was critically appraised and a 1-day round-table discussion was conducted to derive expert consensus on key issues in FMT research...
October 14, 2019: Gut
#16
Lisa M Olsson, Christine Poitou, Valentina Tremaroli, Muriel Coupaye, Judith Aron-Wisnewsky, Fredrik Bäckhed, Karine Clément, Robert Caesar
OBJECTIVE: The gut microbiota has been implicated in the aetiology of obesity and associated comorbidities. Patients with Prader-Willi syndrome (PWS) are obese but partly protected against insulin resistance. We hypothesised that the gut microbiota of PWS patients differs from that of non-genetically obese controls and correlate to metabolic health. Therefore, here we used PWS as a model to study the role of gut microbiota in the prevention of metabolic complications linked to obesity...
October 14, 2019: Gut
#17
Luisa W Hugerth, Anna Andreasson, Nicholas J Talley, Anna M Forsberg, Lars Kjellström, Peter Thelin Schmidt, Lars Agreus, Lars Engstrand
OBJECTIVE: The ethiopathogenesis of irritable bowel syndrome (IBS) is unknown. While a link to the gut microbiome is postulated, the heterogeneity of the healthy gut makes it difficult to draw definitive conclusions. We aimed to describe the faecal and mucosa-associated microbiome (MAM) and health correlates on a community cohort of healthy and IBS individuals with no colonoscopic findings. DESIGN: The PopCol study recruited a random sample of 3556 adults; 745 underwent colonoscopy...
October 10, 2019: Gut
#18
LETTER
Matthew Banks, Noriya Uedo, Pradeep Bhandari, Takuji Gotoda
No abstract text is available yet for this article.
October 5, 2019: Gut
#19
Avital Guedj, Yael Volman, Anat Geiger-Maor, Julia Bolik, Neele Schumacher, Sven Künzel, John F Baines, Yuval Nevo, Sharona Elgavish, Eithan Galun, Hagai Amsalem, Dirk Schmidt-Arras, Jacob Rachmilewitz
OBJECTIVE: Failing to properly repair damaged DNA drives the ageing process. Furthermore, age-related inflammation contributes to the manifestation of ageing. Recently, we demonstrated that the efficiency of repair of diethylnitrosamine (DEN)-induced double-strand breaks (DSBs) rapidly declines with age. We therefore hypothesised that with age, the decline in DNA damage repair stems from age-related inflammation. DESIGN: We used DEN-induced DNA damage in mouse livers and compared the efficiency of their resolution in different ages and following various permutations aimed at manipulating the liver age-related inflammation...
October 5, 2019: Gut
#20
Qiang Wang, Chen Chen, Qingqing Ding, Yan Zhao, Zhangding Wang, Junjie Chen, Zerun Jiang, Yan Zhang, Guifang Xu, Jingjing Zhang, Jianwei Zhou, Beicheng Sun, Xiaoping Zou, Shouyu Wang
OBJECTIVE: N6 -methyladenosine (m6 A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation and progression via the regulation of RNA function. This study explored the biological function and clinical significance of METTL3 in gastric cancer (GC). DESIGN: The prognostic value of METTL3 expression was evaluated using tissue microarray and immunohistochemical staining analyses in a human GC cohort. The biological role and mechanism of METTL3 in GC tumour growth and liver metastasis were determined in vitro and in vivo...
October 3, 2019: Gut
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