Lonne W T Meulen, Alouisa J P van de Wetering, Marie-Eline P H Debeuf, Zlatan Mujagic, Ad A M Masclee
No abstract text is available yet for this article.
January 14, 2020: Gut
Cheuk-Chun Szeto, Kentaro Sugano, Ji-Guang Wang, Kazuma Fujimoto, Samuel Whittle, Gopesh K Modi, Chen-Huen Chen, Jeong-Bae Park, Lai-Shan Tam, Kriengsak Vareesangthip, Kelvin K F Tsoi, Francis K L Chan
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE: To develop a set of multidisciplinary recommendations for the safe prescription of NSAIDs. METHODS: Randomised control trials and observational studies published before January 2018 were reviewed, with 329 papers included for the synthesis of evidence-based recommendations...
January 14, 2020: Gut
Vaidehi Krishnan, Debbie Xiu En Lim, Phuong Mai Hoang, Supriya Srivastava, Junichi Matsuo, Kie Kyon Huang, Feng Zhu, Khek Yu Ho, Jimmy Bok Yan So, Christopher Khor, Stephen Tsao, Ming Teh, Kwong Ming Fock, Tiing Leong Ang, Anand D Jeyasekharan, Patrick Tan, Khay-Guan Yeoh, Yoshiaki Ito
OBJECTIVE: Intestinal metaplasia (IM) is a premalignant stage that poses a greater risk for subsequent gastric cancer (GC). However, factors regulating IM to GC progression remain unclear. Previously, activated DNA damage response (DDR) signalling factors were shown to engage tumour-suppressive networks in premalignant lesions. Here, we interrogate the relationship of DDR signalling to mutational accumulation in IM lesions. DESIGN: IM biopsies were procured from the gastric cancer epidemiology programme, an endoscopic surveillance programme where biopsies have been subjected to (epi)genomic characterisation...
January 14, 2020: Gut
Abdul K Siraj, Tariq Masoodi, Rong Bu, Sandeep Kumar Parvathareddy, Sarah Siraj, Ali Alassiri, Fouad Al-Dayel, Fowzan S Alkuraya, Khawla S Al-Kuraya
No abstract text is available yet for this article.
January 10, 2020: Gut
Cyril Sobolewski, Daniel Abegg, Flavien Berthou, Dobrochna Dolicka, Nicolas Calo, Christine Sempoux, Margot Fournier, Christine Maeder, Anne-Sophie Ay, Pierre-Alain Clavien, Bostjan Humar, Jean-François Dufour, Alexander Adibekian, Michelangelo Foti
OBJECTIVE: Hepatocellular carcinoma (HCC) development occurs with non-alcoholic fatty liver disease (NAFLD) in the absence of cirrhosis and with an increasing incidence due to the obesity pandemic. Mutations of tumour suppressor (TS) genes and oncogenes (ONC) have been widely characterised in HCC. However, mounting evidence indicates that non-genomic alterations of TS/ONC occur early with NAFLD, thereby potentially promoting hepatocarcinogenesis in an inflammatory/fibrotic context. The aim of this study was to identify and characterise these alterations...
January 9, 2020: Gut
Noémie Oechslin, Darius Moradpour, Jérôme Gouttenoire
No abstract text is available yet for this article.
January 8, 2020: Gut
Peter Bossuyt, Hiroshi Nakase, Séverine Vermeire, Gert de Hertogh, Tom Eelbode, Marc Ferrante, Tadashi Hasegawa, Hilde Willekens, Yousuke Ikemoto, Takao Makino, Raf Bisschops
BACKGROUND: The objective evaluation of endoscopic disease activity is key in ulcerative colitis (UC). A composite of endoscopic and histological factors is the goal in UC treatment. We aimed to develop an operator-independent computer-based tool to determine UC activity based on endoscopic images. METHODS: First, we built a computer algorithm using data from 29 consecutive patients with UC and 6 healthy controls (construction cohort). The algorithm (red density: RD) was based on the red channel of the red-green-blue pixel values and pattern recognition from endoscopic images...
January 8, 2020: Gut
Einat Cinnamon, Eli Pikarsky
No abstract text is available yet for this article.
January 8, 2020: Gut
Sho Suzuki, Takuji Gotoda, Chika Kusano, Hisatomo Ikehara, Ryoji Ichijima, Motoki Ohyauchi, Hirotaka Ito, Masashi Kawamura, Yohei Ogata, Masahiko Ohtaka, Moriyasu Nakahara, Koichi Kawabe
OBJECTIVE: To date, no randomised trials have compared the efficacy of vonoprazan and amoxicillin dual therapy with other standard regimens for Helicobacter pylori treatment. This study aimed to investigate the efficacy of the 7-day vonoprazan and low-dose amoxicillin dual therapy as a first-line H. pylori treatment, and compared this with vonoprazan-based triple therapy. DESIGN: This prospective, randomised clinical trial was performed at seven Japanese institutions...
January 8, 2020: Gut
Camille Besombes, Richard Njouom, Juliette Paireau, Guillaume Lachenal, Gaëtan Texier, Mathurin Tejiokem, Simon Cauchemez, Jacques Pépin, Arnaud Fontanet
OBJECTIVE: To investigate the distribution and risk factors of hepatitis delta virus (HDV) infection in Cameroon. DESIGN: We tested for hepatitis B virus (HBV) surface antigen (HBsAg) and anti-HDV antibody 14 150 samples collected during a survey whose participants were representative of the Cameroonian adult population. The samples had already been tested for hepatitis C virus and HIV antibodies. RESULTS: Overall, 1621/14 150 (weighted prevalence=11...
January 6, 2020: Gut
Quentin Bayard, Stefano Caruso, Gabrielle Couchy, Sandra Rebouissou, Paulette Bioulac Sage, Charles Balabaud, Valerie Paradis, Nathalie Sturm, Anne de Muret, Catherine Guettier, Benjamin Bonsang, Christiane Copie, Eric Letouzé, Julien Calderaro, Sandrine Imbeaud, Jean-Charles Nault, Jessica Zucman-Rossi
BACKGROUND: Inflammatory hepatocellular adenomas (IHCAs) are benign liver tumours characterised by an activation of the janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway caused by oncogenic activating mutations. However, a subset of IHCA lacks of identified mutation explaining the inflammatory phenotype. METHODS: 657 hepatocellular adenomas developed in 504 patients were analysed for gene expression of 17 genes and for mutations in seven genes by sequencing...
January 6, 2020: Gut
Hamed Khalili, Niclas Håkansson, Simon S Chan, Ye Chen, Paul Lochhead, Jonas F Ludvigsson, Andrew T Chan, Andrew R Hart, Ola Olén, Alicja Wolk
OBJECTIVE: To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC). DESIGN: We conducted a prospective cohort study of 83 147 participants (age range: 45-79 years) enrolled in the Cohort of Swedish Men and Swedish Mammography Cohort. A validated food frequency questionnaire was used to calculate an adherence score to a modified Mediterranean diet (mMED) at baseline in 1997. Incident diagnoses of CD and UC were ascertained from the Swedish Patient Register...
January 3, 2020: Gut
Xia Chen, Pan Li, Mian Liu, Huimin Zheng, Yan He, Mu-Xuan Chen, Wenli Tang, Xiaojing Yue, Yongxin Huang, Lingling Zhuang, Zhijian Wang, Mei Zhong, Guibao Ke, Haoyue Hu, Yinglin Feng, Yun Chen, Yanhong Yu, Hongwei Zhou, Liping Huang
OBJECTIVE: Pre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown. DESIGN: We performed a case-control study to compare the faecal microbiome of PE and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address the causative relationship between gut dysbiosis and PE, we used faecal microbiota transplantation (FMT) in an antibiotic-treated mouse model...
January 3, 2020: Gut
Ning Ding, Xin Zhang, Xue Di Zhang, Jun Jing, Shan Shan Liu, Yun Ping Mu, Li Li Peng, Yun Jing Yan, Geng Miao Xiao, Xin Yun Bi, Hao Chen, Fang Hong Li, Bing Yao, Allan Z Zhao
OBJECTIVE: High-fat diet (HFD)-induced metabolic disorders can lead to impaired sperm production. We aim to investigate if HFD-induced gut microbiota dysbiosis can functionally influence spermatogenesis and sperm motility. DESIGN: Faecal microbes derived from the HFD-fed or normal diet (ND)-fed male mice were transplanted to the mice maintained on ND. The gut microbes, sperm count and motility were analysed. Human faecal/semen/blood samples were collected to assess microbiota, sperm quality and endotoxin...
January 2, 2020: Gut
Silvia Sookoian, Adrian Salatino, Gustavo Osvaldo Castaño, Maria Silvia Landa, Cinthia Fijalkowky, Martin Garaycoechea, Carlos Jose Pirola
OBJECTIVE: We aimed to characterise the liver tissue bacterial metataxonomic signature in two independent cohorts of patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) diagnosis, as differences in the host phenotypic features-from moderate to severe obesity-may be associated with significant changes in the microbial DNA profile. DESIGN AND METHODS: Liver tissue samples from 116 individuals, comprising of 47 NAFLD overweight or moderately obese patients, 50 NAFLD morbidly obese patients elected for bariatric surgery and 19 controls, were analysed using high-throughput 16S rRNA gene sequencing...
January 2, 2020: Gut
Matias A Avila, Jean-François Dufour, Alexander L Gerbes, Fabien Zoulim, Ramon Bataller, Patrizia Burra, Helena Cortez-Pinto, Bin Gao, Ian Gilmore, Philippe Mathurin, Christophe Moreno, Vladimir Poznyak, Bernd Schnabl, Gyongyi Szabo, Maja Thiele, Mark R Thursz
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention...
December 26, 2019: Gut
Wenjie Ma, Andrew T Chan
No abstract text is available yet for this article.
December 24, 2019: Gut
Joana Carvão, Armando Peixoto, Elisabete Rios, Guilherme Macedo
No abstract text is available yet for this article.
December 24, 2019: Gut
Jiabin Cai, Zhou Zhang, Chuan He, Wei Zhang, Jia Fan
No abstract text is available yet for this article.
December 23, 2019: Gut
Christian Maaser, Frauke Petersen, Ulf Helwig, Imma Fischer, Alexander Roessler, Stefan Rath, Dorothee Lang, Torsten Kucharzik
OBJECTIVE: Prospective evaluation of intestinal ultrasound (IUS) for disease monitoring of patients with ulcerative colitis (UC) in routine medical practice. DESIGN: TRansabdominal Ultrasonography of the bowel in Subjects with IBD To monitor disease activity with UC (TRUST&UC) was a prospective, observational study at 42 German inflammatory bowel disease-specialised centres representing different care levels. Patients with a diagnosis of a proctosigmoiditis, left-sided colitis or pancolitis currently in clinical relapse (defined as Short Clinical Colitis Activity Index ≥5) were enrolled consecutively...
December 20, 2019: Gut
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