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• journal#1
Shixian Hu, Arnau Vich Vila, Ranko Gacesa, Valerie Collij, Christine Stevens, Jack M Fu, Isaac Wong, Michael E Talkowski, Manuel A Rivas, Floris Imhann, Laura Bolte, Hendrik van Dullemen, Gerard Dijkstra, Marijn C Visschedijk, Eleonora A Festen, Ramnik J Xavier, Jingyuan Fu, Mark J Daly, Cisca Wijmenga, Alexandra Zhernakova, Alexander Kurilshikov, Rinse K Weersma
OBJECTIVE: Both the gut microbiome and host genetics are known to play significant roles in the pathogenesis of IBD. However, the interaction between these two factors and its implications in the aetiology of IBD remain underexplored. Here, we report on the influence of host genetics on the gut microbiome in IBD. DESIGN: To evaluate the impact of host genetics on the gut microbiota of patients with IBD, we combined whole exome sequencing of the host genome and whole genome shotgun sequencing of 1464 faecal samples from 525 patients with IBD and 939 population-based controls...
July 10, 2020: Gut
#2
Terry Cheuk-Fung Yip, Grace Chung-Yan Lui, Vincent Wai-Sun Wong, Viola Chi-Ying Chow, Tracy Hang-Yee Ho, Timothy Chun-Man Li, Yee-Kit Tse, David Shu-Cheong Hui, Henry Lik-Yuen Chan, Grace Lai-Hung Wong
OBJECTIVE: Data on serial liver biochemistries of patients infected by different human coronaviruses (HCoVs) are lacking. The impact of liver injury on adverse clinical outcomes in coronavirus disease 2019 (COVID-19) patients remains unclear. DESIGN: This was a retrospective cohort study using data from a territory-wide database in Hong Kong. COVID-19, severe acute respiratory syndrome (SARS) and other HCoV patients were identified by diagnosis codes and/or virological results...
July 8, 2020: Gut
#3
Laura Reyes-Uribe, Wenhui Wu, Ozkan Gelincik, Prashant V Bommi, Alejandro Francisco-Cruz, Luisa M Solis, Patrick M Lynch, Ramona Lim, Elena M Stoffel, Priyanka Kanth, N Jewel Samadder, Maureen E Mork, Melissa W Taggart, Ginger L Milne, Lawrence J Marnett, Lana Vornik, Diane D Liu, Maria Revuelta, Kyle Chang, Y Nancy You, Levy Kopelovich, Ignacio I Wistuba, J Jack Lee, Shizuko Sei, Robert H Shoemaker, Eva Szabo, Ellen Richmond, Asad Umar, Marjorie Perloff, Powel H Brown, Steven M Lipkin, Eduardo Vilar
OBJECTIVE: Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity and discover novel molecular pathways involved in the activity of naproxen as primary and secondary chemoprevention in patients with LS. DESIGN: We conducted a Phase Ib, placebo-controlled, randomised clinical trial of two dose levels of naproxen sodium (440 and 220 mg) administered daily for 6 months to 80 participants with LS, and a co-clinical trial using a genetically engineered mouse model of LS and patient-derived organoids (PDOs)...
July 8, 2020: Gut
#4
LETTER
Jyh-Ming Liou, Mei-Jyh Chen, Tzu-Chan Hong, Ming-Shiang Wu
No abstract text is available yet for this article.
July 3, 2020: Gut
#5
Gianluca Ianiro, Benjamin H Mullish, Colleen R Kelly, Zain Kassam, Ed J Kuijper, Siew C Ng, Tariq H Iqbal, Jessica R Allegretti, Stefano Bibbò, Harry Sokol, Faming Zhang, Monika Fischer, Samuel Paul Costello, Josbert J Keller, Luca Masucci, Joffrey van Prehn, Gianluca Quaranta, Mohammed Nabil Quraishi, Jonathan Segal, Dina Kao, Reetta Satokari, Maurizio Sanguinetti, Herbert Tilg, Antonio Gasbarrini, Giovanni Cammarota
The COVID-19 pandemic has led to an exponential increase in SARS-CoV-2 infections and associated deaths, and represents a significant challenge to healthcare professionals and facilities. Individual countries have taken several prevention and containment actions to control the spread of infection, including measures to guarantee safety of both healthcare professionals and patients who are at increased risk of infection from COVID-19. Faecal microbiota transplantation (FMT) has a well-established role in the treatment of Clostridioides difficile infection...
July 3, 2020: Gut
#6
Florian Hentschel, Andreas Georg Schreyer, Stefan Lüth
No abstract text is available yet for this article.
July 3, 2020: Gut
#7
LETTER
Anita Lavery, Jaine K Blayney, Richard C Turkington
No abstract text is available yet for this article.
June 30, 2020: Gut
#8
LETTER
Jue Liu, Liyuan Tao, Xia Liu, Hongyan Yao, Shicheng Yu, Qiqi Wang, Jiaojiao Zhang, Zhancheng Gao, Rongmeng Jiang, Wenzhan Jing, Min Liu
No abstract text is available yet for this article.
June 30, 2020: Gut
#9
Melina Arnold, Jacques Ferlay, Mark I van Berge Henegouwen, Isabelle Soerjomataram
OBJECTIVES: To provide updated estimates of the global burden of oesophageal and gastric cancer by subsite and type. METHODS: Using data from population-based cancer registries, proportions of oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC) out of all oesophageal as well as cardia gastric cancer (CGC) and non-CGC (NCGC) out of all gastric cancer cases were computed by country, sex and age group. Proportions were subsequently applied to the estimated numbers of oesophageal and gastric cancer cases from GLOBOCAN 2018...
June 30, 2020: Gut
#10
LETTER
Zillah Cargill, Sarah E Brown, Geoff Dusheiko, Kosh Agarwal
No abstract text is available yet for this article.
June 30, 2020: Gut
#11
Katharina Zoldan, Maike Hofmann
No abstract text is available yet for this article.
June 30, 2020: Gut
#12
Veera Raghavan Thangapandi, Oskar Knittelfelder, Mario Brosch, Eleonora Patsenker, Olga Vvedenskaya, Stephan Buch, Sebastian Hinz, Alexander Hendricks, Marina Nati, Alexander Herrmann, Devavrat Ravindra Rekhade, Thomas Berg, Madlen Matz-Soja, Klaus Huse, Edda Klipp, Josch K Pauling, Judith Ah Wodke, Jacobo Miranda Ackerman, Malte von Bonin, Elmar Aigner, Christian Datz, Witigo von Schönfels, Sophie Nehring, Sebastian Zeissig, Christoph Röcken, Andreas Dahl, Triantafyllos Chavakis, Felix Stickel, Andrej Shevchenko, Clemens Schafmayer, Jochen Hampe, Pallavi Subramanian
OBJECTIVE: The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including non-alcoholic fatty liver disease (NAFLD), alcohol-related liver disease, hepatitis B and C. We aim to understand the mechanism by which the rs641738C>T variant contributes to pathogenesis of NAFLD. DESIGN: Mice with hepatocyte-specific deletion of MBOAT7 (Mboat7Δhep ) were generated and livers were characterised by histology, flow cytometry, qPCR, RNA sequencing and lipidomics...
June 26, 2020: Gut
#13
Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study.
Bing Zhang, Hohui E Wang, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Tzeng-Ji Chen, Yen-Po Wang, Mu-Hong Chen
OBJECTIVE: Increasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the 'gut-brain axis'. Recent findings suggest a connection between IBD and development of Parkinson's disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored. DESIGN: Using the Taiwanese National Health Insurance Research Database, we performed comparative analysis of 1742 patients with IBD ≥45 years old against 17 420 controls to assess dementia risk following IBD diagnosis...
June 23, 2020: Gut
#14
Gregory B Lesinski
No abstract text is available yet for this article.
June 22, 2020: Gut
#15
LETTER
Sven Stengel, Arndt Steube, Nilay Köse-Vogel, Tatiana Kirchberger-Tolstik, Sachin Deshmukh, Tony Bruns
No abstract text is available yet for this article.
June 22, 2020: Gut
#16
LETTER
Kevin J Monahan, Anne Lincoln, James E East, Sally Benton, John Burn, Bianca DeSouza, Helen Hanson, Fiona Lalloo, Terri McVeigh, Matthew D Rutter, Katie Snape, Huw J W Thomas, Peter Sasieni
No abstract text is available yet for this article.
June 22, 2020: Gut
#17
LETTER
Ke Zhan, Shengtao Liao, Jinfang Li, Yang Bai, Lin Lv, Keqi Yu, Liewang Qiu, Chuanfei Li, Guodan Yuan, An Zhang, Zhechuan Mei
No abstract text is available yet for this article.
June 22, 2020: Gut
#18
Chiara Becchetti, Marco Fabrizio Zambelli, Luisa Pasulo, Maria Francesca Donato, Federica Invernizzi, Olivier Detry, Géraldine Dahlqvist, Olga Ciccarelli, Maria Cristina Morelli, Montserrat Fraga, Gianluca Svegliati-Baroni, Hans van Vlierberghe, Minneke J Coenraad, Mario Cristobal Romero, Andrea de Gottardi, Pierluigi Toniutto, Luca Del Prete, Claudia Abbati, Didier Samuel, Jacques Pirenne, Frederik Nevens, Jean-François Dufour
OBJECTIVE: Knowledge on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in liver transplant recipients is lacking, particularly in terms of severity of the disease. The aim of this study was to describe the demographic, baseline clinical characteristics and early outcomes of a European cohort of liver transplant recipients with SARS-CoV-2 infection. DESIGN: We conducted an international prospective study across Europe on liver transplant recipients with SARS-CoV-2 infection confirmed by microbiological assay during the first outbreak of COVID-19 pandemic...
June 22, 2020: Gut
#19
Jing Li, Jisu Li, Shiqi Chen, Quan Yuan, Jing Zhang, Jingwen Wu, Qirong Jiang, Qianru Wang, Ning-Shao Xia, Jiming Zhang, Shuping Tong
BACKGROUND AND AIMS: Deletion of 15-nucleotide or 18-nucleotide (nt) covering preS1 ATG frequently arises during chronic infection with HBV genotypes B and C. Since the second ATG is 33nt downstream, they truncate large (L) envelope protein by 11 residues like wild-type genotype D. This study characterised their functional consequences. METHODS: HBV genomes with or without deletion were amplified from a patient with advanced liver fibrosis and assembled into replication competent 1...
June 22, 2020: Gut
#20
Ozge Kayisoglu, Franziska Weiss, Carolin Niklas, Isabella Pierotti, Malvika Pompaiah, Nina Wallaschek, Christoph-Thomas Germer, Armin Wiegering, Sina Bartfeld
OBJECTIVE: The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear. DESIGN: We generated 42 lines of human and murine organoids from gastric and intestinal segments of both adult and fetal tissues. Genome-wide RNA-seq of the organoids provides an expression atlas of the GI epithelium...
June 22, 2020: Gut
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