journal
https://read.qxmd.com/read/37989565/understanding-the-malignant-potential-of-gastric-metaplasia-of-the-oesophagus-and-its-relevance-to-barrett-s-oesophagus-surveillance-individual-level-data-analysis
#1
JOURNAL ARTICLE
Emily L Black, Emma Ococks, Ginny Devonshire, Alvin Wei Tian Ng, Maria O'Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Adam Freeman, Hannah Coles, Rebecca C Fitzgerald
OBJECTIVE: Whether gastric metaplasia (GM) of the oesophagus should be considered as Barrett's oesophagus (BO) is controversial. Given concern intestinal metaplasia (IM) may be missed due to sampling, the UK guidelines include GM as a type of BO. Here, we investigated whether the risk of misdiagnosis and the malignant potential of GM warrant its place in the UK surveillance. DESIGN: We performed a thorough pathology and endoscopy review to follow clinical outcomes in a novel UK cohort of 244 patients, covering 1854 person years of follow-up...
November 21, 2023: Gut
https://read.qxmd.com/read/37989564/time-to-focus-on-the-real-potential-benefit-of-endobiliary-radiofrequency-ablation-stent-patency-in-patients-with-cholangiocarcinoma
#2
LETTER
Jeska A Fritzsche, Esmée Smit, Cyriel Y Ponsioen, Rogier P Voermans
No abstract text is available yet for this article.
November 21, 2023: Gut
https://read.qxmd.com/read/37989563/antiobesity-interventions-options-evidence-and-value
#3
JOURNAL ARTICLE
Elena B Elkin, Chin Hur
No abstract text is available yet for this article.
November 21, 2023: Gut
https://read.qxmd.com/read/37977587/impact-of-climate-change-on-vulnerable-populations
#4
JOURNAL ARTICLE
Govind K Makharia, Anahita Sadeghi, Desmond Leddin, Anthony Costello
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977586/green-gastroenterology-adaptation-resilience-and-an-industry-perspective
#5
JOURNAL ARTICLE
Cassandra Thiel, Emma Pak, Rainer Burkard, Harald Huber
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977585/effects-of-climate-change-on-digestive-health-and-preventative-measures
#6
JOURNAL ARTICLE
Mhairi Claire Donnelly, Nicholas J Talley
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977584/climate-change-paediatric-health-and-ways-that-digestive-health-professionals-can-engage
#7
JOURNAL ARTICLE
Rebecca Philipsborn, Madhumitha Manivannan, Todd L Sack
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977583/the-fundamentals-understanding-the-climate-change-crisis
#8
JOURNAL ARTICLE
Desmond Leddin, Hugh Montgomery
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977582/gastroenterology-climate-action-opportunities-via-education-empowerment-of-trainees-and-research
#9
JOURNAL ARTICLE
Aasma Shaukat, Brijen Shah, Cassandra Dl Fritz, M Bishr Omary
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977581/world-gastroenterology-organisation-gut-commentary-series-on-digestive-health-and-climate-change
#10
JOURNAL ARTICLE
M Bishr Omary, Desmond Leddin, Geoffrey Metz, Andrew M Veitch, Emad M El-Omar, Guilherme Macedo, Mai Ling Perman
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977580/approaches-for-greening-endoscopy-and-reducing-waste
#11
JOURNAL ARTICLE
João A Cunha Neves, Enrique Rodríguez de Santiago, Lars Aabakken
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977579/nhs-efforts-in-england-to-mitigate-the-climate-crisis-uniting-nurses-and-gastroenterologists
#12
JOURNAL ARTICLE
Robin Baddeley, Nick Watts, Leigh Donnelly
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37977578/carbon-footprint-of-gastroenterology-practice
#13
JOURNAL ARTICLE
Heiko Pohl, Robin Baddeley, Bu'Hussain Hayee
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37973365/chimeric-antigen-receptors-of-hbv-envelope-proteins-inhibit-hepatitis-b-surface-antigen-secretion
#14
JOURNAL ARTICLE
Yang Wang, Qiqi Li, Cheng Li, Cong Wang, Shijie Wang, Wenjie Yuan, Demin Yu, Ke Zhang, Bisheng Shi, Xiaomei Chen, Tiantian Liu, Zhenghong Yuan, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
OBJECTIVES: Chronic hepatitis B (CHB) caused by HBV infection greatly increases the risk of liver cirrhosis and hepatocellular carcinoma. Hepatitis B surface antigen (HBsAg) plays critical roles in the pathogenesis of CHB. HBsAg loss is the key indicator for cure of CHB, but is rarely achieved by current approved anti-HBV drugs. Therefore, novel anti-HBV strategies are urgently needed to achieve sustained HBsAg loss. DESIGN: We developed multiple chimeric antigen receptors (CARs) based on single-chain variable fragments (scFvs, namely MA18/7-scFv and G12-scFv), respectively, targeting HBV large and small envelope proteins...
November 16, 2023: Gut
https://read.qxmd.com/read/37973364/practical-approach-to-interpretation-of-48-hour-wireless-ph-monitoring-studies
#15
LETTER
Amrit K Kamboj, Yin Chan, Jason Nasser, Jane E Lim, Bianca W Chang, Ali Rezaie
No abstract text is available yet for this article.
November 16, 2023: Gut
https://read.qxmd.com/read/37968095/spatial-transcriptomics-reveals-a-low-extent-of-transcriptionally-active-hepatitis-b-virus-integration-in-patients-with-hbsag-loss
#16
JOURNAL ARTICLE
Xiaoqi Yu, Qiming Gong, Demin Yu, Yongyan Chen, Ying Jing, Fabien Zoulim, Xinxin Zhang
OBJECTIVE: Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, contributing to the production of hepatitis B surface antigen (HBsAg) and to hepatocarcinogenesis. In this study, we aimed to explore whether transcriptionally active HBV integration events spread throughout the liver tissue in different phases of chronic HBV infection, especially in patients with HBsAg loss. DESIGN: We constructed high-resolution spatial transcriptomes of liver biopsies containing 13 059 tissue spots from 18 patients with chronic HBV infection to analyse the occurrence and relative distribution of transcriptionally active viral integration events...
November 15, 2023: Gut
https://read.qxmd.com/read/37949638/gut-virome-in-inflammatory-bowel-disease-and-beyond
#17
REVIEW
Hein Min Tun, Ye Peng, Luca Massimino, Zhen Ye Sin, Tommaso Lorenzo Parigi, Amanda Facoetti, Shaila Rahman, Silvio Danese, Federica Ungaro
OBJECTIVE: The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota and with the host in a dynamic equilibrium, serving as a key contributor to the maintenance of intestinal homeostasis and functions. However, this equilibrium can be interrupted in certain pathological states, including inflammatory bowel disease, causing dysbiosis that may participate in disease pathogenesis...
November 10, 2023: Gut
https://read.qxmd.com/read/37945330/novel-insights-into-causal-effects-of-serum-lipids-and-lipid-modifying-targets-on-cholelithiasis
#18
JOURNAL ARTICLE
Lanlan Chen, Wei Qiu, Xiaodong Sun, Menghan Gao, Yuexuan Zhao, Mingyue Li, Zhongqi Fan, Guoyue Lv
OBJECTIVE: Different serum lipids and lipid-modifying targets should affect the risk of cholelithiasis differently, however, whether such effects are causal is still controversial and we aimed to answer this question. DESIGN: We prospectively estimated the associations of four serum lipids with cholelithiasis in UK Biobank using the Cox proportional hazard model, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG)...
November 9, 2023: Gut
https://read.qxmd.com/read/37932021/rare-cause-of-obstructive-jaundice
#19
JOURNAL ARTICLE
Sota Nakagami, Toshihiro Morita, Shujiro Yazumi
No abstract text is available yet for this article.
November 6, 2023: Gut
https://read.qxmd.com/read/37918890/gord-and-glp-1-receptor-agonists-an-emerging-concern-for-gastroenterologists
#20
JOURNAL ARTICLE
Benson T Massey
No abstract text is available yet for this article.
November 2, 2023: Gut
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