Most recent papers in the journal Gut

#1

REVIEW

Ten reasons gastroenterologists and hepatologists should be treating obesity.

Michael Camilleri, Emad M El-Omar

No abstract text is available yet for this article.

36944480

March 21, 2023: Gut

#2

JOURNAL ARTICLE

Australian inflammatory bowel disease consensus statements for preconception, pregnancy and breast feeding.

Robyn Laube, Christian P Selinger, Cynthia H Seow, Britt Christensen, Emma Flanagan, Debra Kennedy, Reme Mountifield, Sean Seeho, Antonia Shand, Astrid-Jane Williams, Rupert W Leong

OBJECTIVE: Because pregnancy outcomes tend to be worse in women with inflammatory bowel disease (IBD) than in those without, we aimed to update consensus statements that guide the clinical management of pregnancy in patients with IBD. DESIGN: A multidisciplinary working group was established to formulate these consensus statements. A modified RAND/UCLA appropriateness method was used, consisting of a literature review, online voting, discussion meeting and a second round of voting...

36944479

March 21, 2023: Gut

#3

JOURNAL ARTICLE

Quest for immunological biomarkers in the management of CHB patients.

Antonio Bertoletti, Nina Le Bert

No abstract text is available yet for this article.

36922017

March 15, 2023: Gut

#4

JOURNAL ARTICLE

Comprehensive molecular phenotyping of ARID1A -deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.

Chang Xu, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M Flores, Melissa Pool Pizzi, Atsushi Okabe, Angie Lay Keng Tan, Feng Zhu, Vikrant Kumar, Xiaoyin Lu, Ana Morales Benitez, Benedict Shi Xiang Lian, Haoran Ma, Shamaine Wei Ting Ho, Kalpana Ramnarayanan, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Siti Aishah Binte Abdul Ghani, Su Ting Tay, Xuewen Ong, Ming Hui Lee, Yu Amanda Guo, Hassan Ashktorab, Duane Smoot, Shang Li, Anders Jacobsen Skanderup, Michael A Beer, Roger Sik Yin Foo, Joel Shi Hao Wong, Kaushal Sanghvi, Wei Peng Yong, Raghav Sundar, Atsushi Kaneda, Shyam Prabhakar, Pawel Karol Mazur, Jaffer A Ajani, Khay Guan Yeoh, Jimmy Bok-Yan So, Patrick Tan

OBJECTIVE: Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A -specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss. DESIGN: Genomic profiling of GC patients including a Singapore cohort (>200 patients) was performed to derive mutational signatures of ARID1A inactivation across molecular subtypes. Single-cell transcriptomic profiles of ARID1A -mutated GCs were analysed to examine tumour microenvironmental changes arising from ARID1A loss...

36918265

March 14, 2023: Gut

#5

LETTER

Post-COVID-19 irritable bowel syndrome.

Cong Dai, Yu-Hong Huang, Min Jiang

No abstract text is available yet for this article.

36898830

March 10, 2023: Gut

#6

JOURNAL ARTICLE

New insights into an old paradigm: why IgA accumulates in alcoholic liver disease and what could be its role.

Dragos Ciocan, Williams Turpin

No abstract text is available yet for this article.

36898829

March 10, 2023: Gut

#7

JOURNAL ARTICLE

Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer.

Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel mechanistic approaches to overcome or prevent resistance in PDAC. DESIGN: We used in vitro and in vivo models of resistant PDAC and integrated epigenomic, transcriptomic, nascent RNA and chromatin topology data. We identified a JunD-driven subgroup of enhancers, called interactive hubs (iHUBs), which mediate transcriptional reprogramming and chemoresistance in PDAC...

36889906

March 8, 2023: Gut

#8

LETTER

'Family-based' strategy for Helicobacter pylori infection screening: an efficient alternative to 'test and treat' strategy.

Jiafeng Zhang, Yuchen Deng, Chang Liu, Huiquan Wang, Heifei Ren, Sai Chen, Lei Chen, Bin Shi, Lin Zhou

No abstract text is available yet for this article.

36882194

March 7, 2023: Gut

#9

LETTER

Significant underestimation of preventive effects in colorectal cancer screening trial.

Thomas Heisser, Michael Hoffmeister, Hermann Brenner

No abstract text is available yet for this article.

36882193

March 7, 2023: Gut

#10

LETTER

Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments.

Eva Zhang, Thi H O Nguyen, Lilith F Allen, Lukasz Kedzierski, Louise C Rowntree, So Young Chang, Wuji Zhang, Jennifer R Habel, Isabelle J Foo, Tejas Menon, Jeni Mitchell, Rupert W Leong, Katherine Bond, Deborah A Williamson, Katherine Kedzierka, Britt Christensen

No abstract text is available yet for this article.

36878683

March 6, 2023: Gut

#11

LETTER

Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients.

Andreea Zamfir-Taranu, Britt-Sabina Löscher, Diab M Husein, Abdullah Hoter, Koldo Garcia-Etxebarria, Usune Etxeberria, Lucía Gayoso, Gabriele Mayr, Clara Nilholm, Rita J Gustafsson, Oliver Ozaydin, Tenghao Zheng, Cristina Esteban-Blanco, Isotta Bozzarelli, Ferdinando Bonfiglio, Sandra Rizk, Andre Franke, Luis Bujanda, Hassan Y Naim, Bodil Ohlsson, Mauro D'Amato

No abstract text is available yet for this article.

36878682

March 6, 2023: Gut

#12

LETTER

Empiric use of standard triple therapy in Helicobacter pylori eradication does not require readjustment in the clarithromycin resistance cut-off point.

Peter Malfertheiner, Francis Megraud, Theodore Rokkas, Javier P Gisbert

No abstract text is available yet for this article.

36878681

March 6, 2023: Gut

#13

LETTER

Atrophic autoimmune gastritis: 'a muddled or misguided core concept compromises our overall comprehension of the problem'.

Massimo Rugge, Robert M Genta, Peter Malfertheiner, David Y Graham

No abstract text is available yet for this article.

36868846

March 3, 2023: Gut

#14

JOURNAL ARTICLE

Diagnostic dilemma: a patient with diarrhoea.

Nikhita Sane, Ashley Bloom

No abstract text is available yet for this article.

36868845

March 3, 2023: Gut

#15

LETTER

Gastric cancer risk in autoimmune gastritis: evidence versus opinion.

Massimo Rugge, Robert M Genta, Peter Malfertheiner, David Y Graham

No abstract text is available yet for this article.

36849227

February 27, 2023: Gut

#16

JOURNAL ARTICLE

Patient selection for urgent endoscopic retrograde cholangio-pancreatography by endoscopic ultrasound in predicted severe acute biliary pancreatitis (APEC-2): a multicentre prospective study.

Nora D Hallensleben, Pauline M C Stassen, Nicolien J Schepers, Marc G Besselink, Marie-Paule G F Anten, Olaf J Bakker, Thomas L Bollen, David W da Costa, Sven M van Dijk, Hendrik M van Dullemen, Marcel G W Dijkgraaf, Brechje van Eijck, Casper H J van Eijck, Willemien Erkelens, Nicole S Erler, Paul Fockens, Erwin-Jan M van Geenen, Janneke van Grinsven, Wouter L Hazen, Robbert A Hollemans, Jeanin E van Hooft, Jeroen M Jansen, Frank J G M Kubben, Sjoerd D Kuiken, Alexander C Poen, Rutger Quispel, Rogier J de Ridder, Tessa E H Römkens, Erik J Schoon, Matthijs P Schwartz, Tom C J Seerden, Xavier J N M Smeets, B W Marcel Spanier, Adriaan C I T L Tan, Willem J Thijs, Robin Timmer, Devica S Umans, Niels G Venneman, Robert C Verdonk, Frank P Vleggaar, Wim van de Vrie, Roy L J van Wanrooij, Ben J Witteman, Hjalmar C van Santvoort, Stefan A W Bouwense, Marco J Bruno

OBJECTIVE: Routine urgent endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic biliary sphincterotomy (ES) does not improve outcome in patients with predicted severe acute biliary pancreatitis. Improved patient selection for ERCP by means of endoscopic ultrasonography (EUS) for stone/sludge detection may challenge these findings. DESIGN: A multicentre, prospective cohort study included patients with predicted severe acute biliary pancreatitis without cholangitis...

36849226

February 27, 2023: Gut

#17

JOURNAL ARTICLE

SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.

Jing Liu, Weiwei Bai, Tianxing Zhou, Yongjie Xie, Bo Yang, Jingyan Sun, Yifei Wang, Xueyang Li, Xupeng Hou, Ziyun Liu, Danqi Fu, Jingrui Yan, Wenna Jiang, Kaili Zhao, Bodong Zhou, Shuai Yuan, Yu Guo, Hongwei Wang, Antao Chang, Song Gao, Lei Shi, Chongbiao Huang, Shengyu Yang, Jihui Hao

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal tumour with limited treatment options. Here, we identified syndecan binding protein (SDCBP), also known as syntenin1, as a novel targetable factor in promoting PDAC tumour progression. We also explored a therapeutic strategy for suppressing SDCBP expression. DESIGN: We used samples from patients with PDAC, human organoid models, LSL-KrasG12D/+mice, LSL-Trp53R172H/+ and Pdx1-Cre (KPC) mouse models, and PDX mouse models...

36828627

February 24, 2023: Gut

#18

JOURNAL ARTICLE

Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study.

Georg Beyer, Florian Kasprowicz, Anke Hannemann, Ali Aghdassi, Patrick Thamm, Henry Volzke, Markus M Lerch, Jens-Peter Kühn, Julia Mayerle

OBJECTIVE: Changes of the pancreaticobiliary ducts herald disease. Magnetic resonance cholangiopancreatography (MRCP) allows accurate duct visualisation. Data on reliable upper reference ranges are missing. DESIGN: Cross-sectional whole body MRI data from the population-based Study of Health in Pomerania were analysed. The width of the common bile duct (CBD) and the pancreatic duct (PD) was determined. We aimed to describe the distribution of physiological duct diameters on MRCP in a population of healthy subjects and to identify factors influencing duct size...

36828626

February 24, 2023: Gut

#19

LETTER

Antibiotic use and inflammatory bowel disease: number needed to harm?

Jonas F Ludvigsson

No abstract text is available yet for this article.

36810144

February 21, 2023: Gut

#20

JOURNAL ARTICLE

MicroRNA-223: a key regulator of liver tumour microenvironment.