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https://read.qxmd.com/read/31300518/mirnas-and-nafld-from-pathophysiology-to-therapy
#1
REVIEW
Monika Gjorgjieva, Cyril Sobolewski, Dobrochna Dolicka, Marta Correia de Sousa, Michelangelo Foti
Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of hepatic metabolism. Epigenetic mechanisms, in particular those associated with deregulation of the expressions and activities of microRNAs (miRNAs), play a major role in metabolic disorders associated with NAFLD and their progression towards more severe stages of the disease. In this review, we discuss the recent progress addressing the role of the many facets of complex miRNA regulatory networks in the development and progression of NAFLD...
July 12, 2019: Gut
https://read.qxmd.com/read/31300517/liver-organoids-from-basic-research-to-therapeutic-applications
#2
REVIEW
Nicole Prior, Patricia Inacio, Meritxell Huch
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ...
July 12, 2019: Gut
https://read.qxmd.com/read/31300516/meta-analysis-of-the-accuracy-of-liver-imaging-reporting-and-data-system-category-4-or-5-for-diagnosing-hepatocellular-carcinoma
#3
LETTER
Dong Hwan Kim, Sang Hyun Choi, Seong Ho Park, Kyung Won Kim, Jae Ho Byun, So Yeon Kim, Seung Soo Lee, Yong Moon Shin, Hyung Jin Won, Pyo-Nyun Kim
No abstract text is available yet for this article.
July 12, 2019: Gut
https://read.qxmd.com/read/31300515/ibd-prevalence-in-lothian-scotland-derived-by-capture-recapture-methodology
#4
Gareth-Rhys Jones, Mathew Lyons, Nikolas Plevris, Philip W Jenkinson, Cathy Bisset, Christopher Burgess, Shahida Din, James Fulforth, Paul Henderson, Gwo-Tzer Ho, Kathryn Kirkwood, Colin Noble, Alan G Shand, David C Wilson, Ian Dr Arnott, Charlie W Lees
OBJECTIVE: IBD prevalence is estimated to be rising, but no detailed, recent UK data are available. The last reported prevalence estimate in the UK was 0.40% in 2003. We aimed to establish the current, and project future, prevalence in Lothian, Scotland. DESIGN: We conducted an all-age multiparameter search strategy using inpatient IBD international classification of disease (ICD-10) coding (K50/51)(1997-2018), IBD pathology coding (1990-2018), primary and secondary care prescribing data (2009-2018) and a paediatric registry, (1997-2018) to identify 'possible' IBD cases up to 31/08/2018...
July 11, 2019: Gut
https://read.qxmd.com/read/31300514/authors-response-giant-oversights-in-the-human-gut-virome
#5
LETTER
Tao Zuo, Siew C Ng
No abstract text is available yet for this article.
July 11, 2019: Gut
https://read.qxmd.com/read/31300513/loss-of-setd2-promotes-kras-induced-acinar-to-ductal-metaplasia-and-epithelia-mesenchymal-transition-during-pancreatic-carcinogenesis
#6
Ningning Niu, Ping Lu, Yanlin Yang, Ruizhe He, Li Zhang, Juanjuan Shi, Jinghua Wu, Minwei Yang, Zhi-Gang Zhang, Lei-Wei Wang, Wei-Qiang Gao, Aida Habtezion, Gary Guishan Xiao, Yongwei Sun, Li Li, Jing Xue
OBJECTIVE: SETD2, the sole histone H3K36 trimethyltransferase, is frequently mutated or deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However, whether SETD2/H3K36me3 alteration results in PDAC remains largely unknown. DESIGN: TCGA(PAAD) public database and PDAC tissue array with SETD2/H3K36me3 staining were used to investigate the clinical relevance of SETD2 in PDAC. Furthermore, to define the role of SETD2 in the carcinogenesis of PDAC, we crossed conditional Setd2 knockout mice ( Pdx cre Setd2 flox/flox ) together with Kras G12D mice...
July 11, 2019: Gut
https://read.qxmd.com/read/31285357/tight-control-for-crohn-s-disease-with-adalimumab-based-treatment-is-cost-effective-an-economic-assessment-of-the-calm-trial
#7
Remo Panaccione, Jean-Frederic Colombel, Simon P L Travis, Peter Bossuyt, Filip Baert, Tomáš Vaňásek, Ahmet Danalıoğlu, Gottfried Novacek, Alessandro Armuzzi, Walter Reinisch, Scott Johnson, Marric Buessing, Ezequiel Neimark, Joel Petersson, Wan-Ju Lee, Geert R D'Haens
OBJECTIVE: To evaluate the cost-effectiveness of an inflammatory biomarker and clinical symptom directed tight control strategy (TC) compared with symptom-based clinical management (CM) in patients with Crohn's disease (CD) naïve to immunosuppressants and biologics using a UK public payer perspective. DESIGN: A regression model estimated weekly CD Activity Index (CDAI)-based transition matrices (remission: CDAI <150, moderate: CDAI ≥150 to <300, severe: CDAI ≥300 to <450, very severe: CDAI ≥450) based on the Effect of Tight Control Management on Crohn's Disease (CALM) trial...
July 8, 2019: Gut
https://read.qxmd.com/read/31278206/british-society-of-gastroenterology-guidelines-on-the-diagnosis-and-management-of-patients-at-risk-of-gastric-adenocarcinoma
#8
Matthew Banks, David Graham, Marnix Jansen, Takuji Gotoda, Sergio Coda, Massimiliano di Pietro, Noriya Uedo, Pradeep Bhandari, D Mark Pritchard, Ernst J Kuipers, Manuel Rodriguez-Justo, Marco R Novelli, Krish Ragunath, Neil Shepherd, Mario Dinis-Ribeiro
Gastric adenocarcinoma carries a poor prognosis, in part due to the late stage of diagnosis. Risk factors include Helicobacter pylori infection, family history of gastric cancer-in particular, hereditary diffuse gastric cancer and pernicious anaemia. The stages in the progression to cancer include chronic gastritis, gastric atrophy (GA), gastric intestinal metaplasia (GIM) and dysplasia. The key to early detection of cancer and improved survival is to non-invasively identify those at risk before endoscopy. However, although biomarkers may help in the detection of patients with chronic atrophic gastritis, there is insufficient evidence to support their use for population screening...
July 5, 2019: Gut
https://read.qxmd.com/read/31270166/role-of-portal-venous-platelet-activation-in-patients-with-decompensated-cirrhosis-and-tips
#9
LETTER
Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
No abstract text is available yet for this article.
July 3, 2019: Gut
https://read.qxmd.com/read/31270165/ibd-bioresource-an-open-access-platform-of-25-000-patients-to-accelerate-research-in-crohn-s-and-colitis
#10
Miles Parkes
No abstract text is available yet for this article.
July 3, 2019: Gut
https://read.qxmd.com/read/31270164/high-dimensional-cytometric-analysis-of-colorectal-cancer-reveals-novel-mediators-of-antitumour-immunity
#11
Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda
OBJECTIVE: A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased characterisation of the immune contexture of CRC. DESIGN: Thirty-six immune cell markers were simultaneously assessed at the single-cell level by mass cytometry in 35 CRC tissues, 26 tumour-associated lymph nodes, 17 colorectal healthy mucosa and 19 peripheral blood samples from 31 patients with CRC...
July 3, 2019: Gut
https://read.qxmd.com/read/31270163/hepatocellular-carcinomas-evolution-to-sorafenib-resistance-through-hepatic-leukaemia-factor
#12
Orlando Musso, Naiara Beraza
No abstract text is available yet for this article.
July 3, 2019: Gut
https://read.qxmd.com/read/31248981/seventy-five-year-old-man-with-unexplained-weight-loss-and-alopecia
#13
Elmer Hoekstra, Jaap van der Laan, Michael van der Voorn
No abstract text is available yet for this article.
June 27, 2019: Gut
https://read.qxmd.com/read/31243055/alterations-of-the-bile-microbiome-in-primary-sclerosing-cholangitis
#14
Timur Liwinski, Roman Zenouzi, Clara John, Hanno Ehlken, Malte C Rühlemann, Corinna Bang, Stefan Groth, Wolfgang Lieb, Marcus Kantowski, Nils Andersen, Guido Schachschal, Tom H Karlsen, Johannes R Hov, Thomas Rösch, Ansgar W Lohse, Joerg Heeren, Andre Franke, Christoph Schramm
BACKGROUND: Patients with primary sclerosing cholangitis (PSC) display an altered colonic microbiome compared with healthy controls. However, little is known on the bile duct microbiome and its interplay with bile acid metabolism in PSC. METHODS: Patients with PSC (n=43) and controls without sclerosing cholangitis (n=22) requiring endoscopic retrograde cholangiography were included prospectively. Leading indications in controls were sporadic choledocholithiasis and papillary adenoma...
June 26, 2019: Gut
https://read.qxmd.com/read/31243054/epigenetic-modulation-of-immunity-towards-new-therapeutic-avenues-in-hepatocellular-carcinoma
#15
Angelique Gougelet
No abstract text is available yet for this article.
June 26, 2019: Gut
https://read.qxmd.com/read/31229990/prevention-of-recurrent-idiopathic-gastroduodenal-ulcer-bleeding-a-double-blind-randomised-trial
#16
Grace L H Wong, Louis H S Lau, Jessica Y L Ching, Yee-Kit Tse, Rachel H Y Ling, Vincent W S Wong, Philip W Y Chiu, James Y W Lau, Francis K L Chan
OBJECTIVE: Patients with a history of Helicobacter pylori -negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding in such patients. DESIGN: In this industry-independent, double-blind, randomised trial, we recruited patients with a history of idiopathic bleeding ulcers...
June 22, 2019: Gut
https://read.qxmd.com/read/31227591/first-known-case-of-paediatric-inflammatory-bowel-disease-in-a-western-lowland-gorilla-may-be-linked-to-a-familial-mutation-in-the-mefv-gene
#17
LETTER
Britt-Sabina Petersen, Bernd Bokemeyer, Christian Wenker, Stefan Hoby, Katrin Baumgartner, Hermann Will, Marc P Hoeppner, Stefan Schreiber, Ingo Mecklenburg, Andre Franke
No abstract text is available yet for this article.
June 21, 2019: Gut
https://read.qxmd.com/read/31227590/jak-selectivity-for-inflammatory-bowel-disease-treatment-does-it-clinically-matter
#18
REVIEW
Silvio Danese, Marjorie Argollo, Catherine Le Berre, Laurent Peyrin-Biroulet
The two major forms of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been shown to improve clinical outcomes in IBD. Janus kinases (JAKs) are tyrosine kinases that bind different intracellular cytokine receptors, leading to phosphorylation of signal transducer and activation of transcription molecules implicated on targeted gene transcription...
June 21, 2019: Gut
https://read.qxmd.com/read/31227589/integrated-multiomic-analysis-reveals-comprehensive-tumour-heterogeneity-and-novel-immunophenotypic-classification-in-hepatocellular-carcinomas
#19
Qi Zhang, Yu Lou, Jiaqi Yang, Junli Wang, Jie Feng, Yali Zhao, Lin Wang, Xing Huang, Qihan Fu, Mao Ye, Xiaozhen Zhang, Yiwen Chen, Ce Ma, Hongbin Ge, Jianing Wang, Jiangchao Wu, Tao Wei, Qi Chen, Junqing Wu, Chengxuan Yu, Yanyu Xiao, Xinhua Feng, Guoji Guo, Tingbo Liang, Xueli Bai
OBJECTIVE: Hepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal tumours, which decreases the efficacy of clinical treatments. Understanding tumour heterogeneity is critical when developing novel treatment strategies. However, a comprehensive investigation of tumour heterogeneity in HCC is lacking, and the available evidence regarding tumour heterogeneity has not led to improvements in clinical practice. DESIGN: We harvested 42 samples from eight HCC patients and evaluated tumour heterogeneity using whole-exome sequencing, RNA sequencing, mass spectrometry-based proteomics and metabolomics, cytometry by time-of-flight, and single-cell analysis...
June 21, 2019: Gut
https://read.qxmd.com/read/31227588/tracing-the-accumulation-of-in-vivo-human-oral-microbiota-elucidates-microbial-community-dynamics-at-the-gateway-to-the-gi-tract
#20
LETTER
Jinfeng Wang, Zhen Jia, Bing Zhang, Lei Peng, Fangqing Zhao
No abstract text is available yet for this article.
June 20, 2019: Gut
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