journal
https://read.qxmd.com/read/33837118/-helicobacter-pylori-resistance-to-antibiotics-in-europe-in-2018-and-its-relationship-to-antibiotic-consumption-in-the-community
#1
Francis Megraud, Robin Bruyndonckx, Samuel Coenen, Linda Wittkop, Te-Din Huang, Martin Hoebeke, Lucie Bénéjat, Philippe Lehours, Herman Goossens, Youri Glupczynski
OBJECTIVE: Our aim was to prospectively assess the antibiotic resistance rates in Helicobacter pylori strains in Europe in 2018 and to study the link between antibiotic consumption in the community and H. pylori resistance levels in the different countries. DESIGN: The proportion of primary antibiotic resistance cases of H. pylori and their corresponding risk factors were investigated in 24 centres from 18 European countries according to a standardised protocol...
April 9, 2021: Gut
https://read.qxmd.com/read/33833068/appendoscopy-in-patients-with-serrated-polyposis-syndrome
#2
LETTER
Rachel Hallit, Maximilien Barret, Arthur Belle, Einas Abou Ali, Marion Dhooge, Romain Coriat, Stanislas Chaussade
No abstract text is available yet for this article.
April 8, 2021: Gut
https://read.qxmd.com/read/33833067/colonoscopic-polypectomy-in-patients-on-anticoagulation-time-to-embrace-the-cold-revolution
#3
LETTER
Nicholas McDonald, Saurabh Chandan, Mohammad Bilal
No abstract text is available yet for this article.
April 8, 2021: Gut
https://read.qxmd.com/read/33833066/hcv-genome-wide-analysis-for-development-of-efficient-culture-systems-and-unravelling-of-antiviral-resistance-in-genotype-4
#4
Long V Pham, Martin Schou Pedersen, Ulrik Fahnøe, Carlota Fernandez-Antunez, Daryl Humes, Kristian Schønning, Santseharay Ramirez, Jens Bukh
OBJECTIVE: HCV-genotype 4 infections are a major cause of liver diseases in the Middle East/Africa with certain subtypes associated with increased risk of direct-acting antiviral (DAA) treatment failures. We aimed at developing infectious genotype 4 cell culture systems to understand the evolutionary genetic landscapes of antiviral resistance, which can help preserve the future efficacy of DAA-based therapy. DESIGN: HCV recombinants were tested in liver-derived cells...
April 8, 2021: Gut
https://read.qxmd.com/read/33833065/six-month-follow-up-of-gut-microbiota-richness-in-patients-with-covid-19
#5
LETTER
Yanfei Chen, Silan Gu, Yunbo Chen, Haifeng Lu, Ding Shi, Jing Guo, Wen-Rui Wu, Ya Yang, Yongtao Li, Kai-Jin Xu, Cheng Ding, Rui Luo, Chenjie Huang, Ling Yu, Min Xu, Ping Yi, Jun Liu, Jing-Jing Tao, Hua Zhang, Longxian Lv, Baohong Wang, Jifang Sheng, Lanjuan Li
No abstract text is available yet for this article.
April 8, 2021: Gut
https://read.qxmd.com/read/33827783/exosome-delivered-cd44v6-c1qbp-complex-drives-pancreatic-cancer-liver-metastasis-by-promoting-fibrotic-liver-microenvironment
#6
Zhibo Xie, Ya Gao, Chiakang Ho, Lequn Li, Chen Jin, Xiaoyi Wang, Caifeng Zou, Yishen Mao, Xiaobo Wang, Qingfeng Li, Deliang Fu, Yi-Fan Zhang
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) shows a remarkable predilection for liver metastasis. Pro-oncogenic secretome delivery and trafficking via exosomes are crucial for pre-metastatic microenvironment formation and metastasis. This study aimed to explore the underlying mechanisms of how PDAC-derived exosomes (Pex) modulate the liver microenvironment and promote metastasis. DESIGN: C57BL/6 mice were 'educated' by tail vein Pex injection. The intrasplenic injection liver metastasis and PDAC orthotopic transplantation models were used to evaluate liver metastasis...
April 7, 2021: Gut
https://read.qxmd.com/read/33827782/letter-to-editor-piecemeal-cold-snare-polypectomy-versus-conventional-endoscopic-mucosal-resection-for-large-sessile-serrated-lesions
#7
LETTER
Haiying Guan, Chunyan Zeng, Youxiang Chen
No abstract text is available yet for this article.
April 7, 2021: Gut
https://read.qxmd.com/read/33820756/long-term-yield-of-pancreatic-cancer-surveillance-in-high-risk-individuals
#8
Kasper A Overbeek, Iris J M Levink, Brechtje D M Koopmann, Femme Harinck, Ingrid C A W Konings, Margreet G E M Ausems, Anja Wagner, Paul Fockens, Casper H van Eijck, Bas Groot Koerkamp, Olivier R C Busch, Marc G Besselink, Barbara A J Bastiaansen, Lydi M J W van Driel, Nicole S Erler, Frank P Vleggaar, Jan-Werner Poley, Djuna L Cahen, Jeanin E van Hooft, Marco J Bruno
OBJECTIVE: We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals. DESIGN: From 2006 to 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater lifetime risk of pancreatic ductal adenocarcinoma (PDAC) after obligatory evaluation by a clinical geneticist and genetic testing, and subjected them to annual surveillance with both endoscopic ultrasonography (EUS) and MRI/cholangiopancreatography (MRI/MRCP) at each visit...
April 5, 2021: Gut
https://read.qxmd.com/read/33811041/long-term-dietary-patterns-are-associated-with-pro-inflammatory-and-anti-inflammatory-features-of-the-gut-microbiome
#9
Laura A Bolte, Arnau Vich Vila, Floris Imhann, Valerie Collij, Ranko Gacesa, Vera Peters, Cisca Wijmenga, Alexander Kurilshikov, Marjo J E Campmans-Kuijpers, Jingyuan Fu, Gerard Dijkstra, Alexandra Zhernakova, Rinse K Weersma
OBJECTIVE: The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation. DESIGN: We investigated the relation between 173 dietary factors and the microbiome of 1425 individuals spanning four cohorts: Crohn's disease, ulcerative colitis, irritable bowel syndrome and the general population...
April 2, 2021: Gut
https://read.qxmd.com/read/33811040/relative-risk-rather-than-absolute-risk-reduction-should-be-preferred-to-sensitise-the-public-to-preventive-actions
#10
Nicolas Chapelle, Myriam Martel, Alan N Barkun, Marc Bardou
No abstract text is available yet for this article.
April 2, 2021: Gut
https://read.qxmd.com/read/33789969/hepatic-hydrothorax-in-the-management-of-cirrhosis
#11
LETTER
Karl Jackson, Richard Davidson, Avinash Aujayeb
No abstract text is available yet for this article.
March 31, 2021: Gut
https://read.qxmd.com/read/33789968/drug-development-for-ulcerative-proctitis-current-concepts
#12
Bénédicte Caron, William J Sandborn, Stefan Schreiber, Remo Panaccione, Silvio Danese, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
March 31, 2021: Gut
https://read.qxmd.com/read/33789967/pan-erbb-kinase-inhibition-augments-cdk4-6-inhibitor-efficacy-in-oesophageal-squamous-cell-carcinoma
#13
Jin Zhou, Zhong Wu, Zhouwei Zhang, Louisa Goss, James McFarland, Ankur Nagaraja, Yingtian Xie, Shengqing Gu, Ke Peng, Yong Zeng, Xiaoyang Zhang, Henry Long, Hiroshi Nakagawa, Anil Rustgi, J Alan Diehl, Matthew Meyerson, Kwok-Kin Wong, Adam Bass
OBJECTIVE: Oesophageal squamous cell carcinoma (OSCC), like other squamous carcinomas, harbour highly recurrent cell cycle pathway alterations, especially hyperactivation of the CCND1/CDK4/6 axis, raising the potential for use of existing CDK4/6 inhibitors in these cancers. Although CDK4/6 inhibition has shown striking success when combined with endocrine therapy in oestrogen receptor positive breast cancer, CDK4/6 inhibitor palbociclib monotherapy has not revealed evidence of efficacy to date in OSCC clinical studies...
March 31, 2021: Gut
https://read.qxmd.com/read/33789966/alterations-in-the-human-oral-and-gut-microbiomes-and-lipidomics-in-covid-19
#14
Zhigang Ren, Haiyu Wang, Guangying Cui, Haifeng Lu, Ling Wang, Hong Luo, Xinhua Chen, Hongyan Ren, Ranran Sun, Wenli Liu, Xiaorui Liu, Chao Liu, Ang Li, Xuemei Wang, Benchen Rao, Chengyu Yuan, Hua Zhang, Jiarui Sun, Xiaolong Chen, Bingjie Li, Chuansong Hu, Zhongwen Wu, Zujiang Yu, Quancheng Kan, Lanjuan Li
OBJECTIVE: To characterise the oral microbiome, gut microbiome and serum lipid profiles in patients with active COVID-19 and recovered patients; evaluate the potential of the microbiome as a non-invasive biomarker for COVID-19; and explore correlations between the microbiome and lipid profile. DESIGN: We collected and sequenced 392 tongue-coating samples, 172 faecal samples and 155 serum samples from Central China and East China. We characterised microbiome and lipid molecules, constructed microbial classifiers in discovery cohort and verified their diagnostic potential in 74 confirmed patients (CPs) from East China and 37 suspected patients (SPs) with IgG positivity...
March 31, 2021: Gut
https://read.qxmd.com/read/33789965/non-compliance-with-colonoscopy-after-a-positive-faecal-immunochemical-test-doubles-the-risk-of-dying-from-colorectal-cancer
#15
Manuel Zorzi, Jessica Battagello, Kevin Selby, Giulia Capodaglio, Susanna Baracco, Silvia Rizzato, Enrico Chinellato, Stefano Guzzinati, Massimo Rugge
BACKGROUND: The risk of colorectal cancer (CRC) among subjects with a positive faecal immunochemical test (FIT) who do not undergo a colonoscopy is unknown. We estimated whether non-compliance with colonoscopy after a positive FIT is associated with increased CRC incidence and mortality. METHODS: The FIT-based CRC screening programme in the Veneto region (Italy) invited persons aged 50 to 69 years with a positive FIT (>20 µg Hb/g faeces) for diagnostic colonoscopy at an endoscopic referral centre...
March 31, 2021: Gut
https://read.qxmd.com/read/33789964/enhanced-donor-screening-for-faecal-microbial-transplantation-during-covid-19
#16
LETTER
Seema Nair Parvathy, John G Lenehan, Ricardo Fernandes, Susan M Poutanen, Susy Hota, Saman Maleki Vareki, Michael Silverman
No abstract text is available yet for this article.
March 31, 2021: Gut
https://read.qxmd.com/read/33789963/long-term-safety-of-infants-from-mothers-with-chronic-hepatitis-b-treated-with-tenofovir-disoproxil-in-china
#17
Calvin Q Pan, Erhei Dai, Zhongping Duan, Guorong Han, Wenjing Zhao, Yuming Wang, Huaihong Zhang, Baoshen Zhu, Hongxiu Jiang, Shuqin Zhang, Xiaohu Zhang, Huaibin Zou, Xiuli Chen, Yu Chen
OBJECTIVE: The physical and neuromental development of infants remains uncertain after fetal exposure to tenofovir disoproxil fumarate (TDF) for the prevention of mother-to-child transmission of HBV. We aimed to investigate the safety of TDF therapy during the third trimester of pregnancy. DESIGN: Infants from a previous randomised controlled trial were recruited for our long-term follow-up (LTFU) study. Mothers with chronic hepatitis B were randomised to receive TDF therapy or no treatment during the third trimester...
March 31, 2021: Gut
https://read.qxmd.com/read/33785559/loss-of-arid1a-activates-mtor-signaling-and-sox9-in-gastric-adenocarcinoma-rationale-for-targeting-arid1a-deficiency
#18
Xiaochuan Dong, Shumei Song, Yuan Li, Yibo Fan, Lulu Wang, Ruiping Wang, Longfei Huo, Ailing Scott, Yan Xu, Melissa Pool Pizzi, Lang Ma, Ying Wang, Jiangkang Jin, Wei Zhao, Xiaodan Yao, Randy L Johnson, Linghua Wang, Zhenning Wang, Guang Peng, Jaffer A Ajani
BACKGROUND: Gastric adenocarcinoma (GAC) is a lethal disease with limited therapeutic options. Genetic alterations in chromatin remodelling gene AT-rich interactive domain 1A ( ARID1A ) and mTOR pathway activation occur frequently in GAC. Targeting the mechanistic target of rapamycin (mTOR) pathway in unselected patients has failed to show survival benefit. A deeper understanding of GAC might identify a subset that can benefit from mTOR inhibition. METHODS: Genomic alterations in ARID1A were analysed in GAC...
March 30, 2021: Gut
https://read.qxmd.com/read/33785558/long-term-exposure-to-fine-particulate-matter-and-non-alcoholic-fatty-liver-disease-a-prospective-cohort-study
#19
LETTER
Shengzhi Sun, Qingqing Yang, Qingxin Zhou, Wangnan Cao, Siwang Yu, Siyan Zhan, Feng Sun
No abstract text is available yet for this article.
March 30, 2021: Gut
https://read.qxmd.com/read/33785557/microbiota-engraftment-after-faecal-microbiota-transplantation-in-obese-subjects-with-type-2-diabetes-a-24-week-double-blind-randomised-controlled-trial
#20
Siew C Ng, Zhilu Xu, Joyce Wing Yan Mak, Keli Yang, Qin Liu, Tao Zuo, Whitney Tang, Louis Lau, Rashid N Lui, Sunny H Wong, Yee Kit Tse, Amy Y L Li, Kitty Cheung, Jessica Y L Ching, Vincent W S Wong, Alice P S Kong, Ronald C W Ma, Elaine Y K Chow, Simon K H Wong, Ivan Chak Hang Ho, Paul K S Chan, Francis K L Chan
OBJECTIVE: The impact of faecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome is uncertain. We aimed to study whether combining FMT with lifestyle modification could enhance the engraftment of favourable microbiota in obese patients with type 2 diabetes mellitus (T2DM). DESIGN: In this double-blind, randomised, placebo-controlled trial, 61 obese subjects with T2DM were randomly assigned to three parallel groups: FMT plus lifestyle intervention (LSI), FMT alone, or sham transplantation plus LSI every 4 weeks for up to week 12...
March 30, 2021: Gut
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