journal
https://read.qxmd.com/read/38782565/-unusual-hcv-genotype-subtypes-origin-distribution-sensitivity-to-direct-acting-antiviral-drugs-and-behaviour-on-antiviral-treatment-and-retreatment
#1
REVIEW
Erwan Vo-Quang, Jean-Michel Pawlotsky
The high genetic diversity of hepatitis C virus (HCV) has led to the emergence of eight genotypes and a large number of subtypes in limited geographical areas. Currently approved pangenotypic DAA regimens have been designed and developed to be effective against the most common subtypes (1a, 1b, 2a, 2b, 2c, 3a, 4a, 5a and 6a). However, large populations living in Africa and Asia, or who have migrated from these regions to industrialised countries, are infected with 'unusual', non-epidemic HCV subtypes, including some that are inherently resistant to currently available direct-acting antiviral (DAA) drugs due to the presence of natural polymorphisms at resistance-associated substitution positions...
May 23, 2024: Gut
https://read.qxmd.com/read/38782564/association-between-primary-hypothyroidism-and-metabolic-dysfunction-associated-steatotic-liver-disease-an-updated-meta-analysis
#2
JOURNAL ARTICLE
Alessandro Mantovani, Alessandro Csermely, Josh Bilson, Niccolò Borella, Scoccia Enrico, Barbara Pecoraro, Emigela Shtembari, Riccardo Morandin, Stergios A Polyzos, Luca Valenti, Herbert Tilg, Christopher D Byrne, Giovanni Targher
OBJECTIVE: Epidemiological studies have reported an association between primary hypothyroidism and metabolic dysfunction-associated steatotic liver disease (MASLD). However, the magnitude of the risk and whether this risk changes with the severity of MASLD remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between primary hypothyroidism and the risk of MASLD. DESIGN: We systematically searched PubMed, Scopus and Web of Science from database inception to 31 January 2024, using predefined keywords to identify observational studies in which MASLD was diagnosed by liver biopsy, imaging or International Classification of Diseases codes...
May 23, 2024: Gut
https://read.qxmd.com/read/38777574/intravital-imaging-dynamic-insights-into-liver-immunity-in-health-and-disease
#3
REVIEW
Yuting Wang, Felix Heymann, Moritz Peiseler
Inflammation is a critical component of most acute and chronic liver diseases. The liver is a unique immunological organ with a dense vascular network, leading to intense crosstalk between tissue-resident immune cells, passenger leucocytes and parenchymal cells. During acute and chronic liver diseases, the multifaceted immune response is involved in disease promoting and repair mechanisms, while upholding core liver immune functions. In recent years, single-cell technologies have unravelled a previously unknown heterogeneity of immune cells, reshaping the complexity of the hepatic immune response...
May 22, 2024: Gut
https://read.qxmd.com/read/38777573/neutrophil-extracellular-traps-activate-hepatic-stellate-cells-and-monocytes-via-nlrp3-sensing-in-alcohol-induced-acceleration-of-mash-fibrosis
#4
JOURNAL ARTICLE
Mrigya Babuta, Caroline Morel, Marcelle de Carvalho Ribeiro, Charles Calenda, Martí Ortega-Ribera, Prashanth Thevkar Nagesh, Christopher Copeland, Yuan Zhuang, Yanbo Wang, Yeonhee Cho, Radhika Joshi, Viliam Brezani, Danielle Hawryluk, Aditi Ashish Datta, Jeeval Mehta, Imad Nasser, Gyongyi Szabo
OBJECTIVE: Alcohol use in metabolic dysfunction-associated steatohepatitis (MASH) is associated with an increased risk of fibrosis and liver-related death. Here, we aimed to identify a mechanism through which repeated alcohol binges exacerbate liver injury in a high fat-cholesterol-sugar diet (MASH diet)-induced model of MASH. DESIGN: C57BL/6 mice received either chow or the MASH diet for 3 months with or without weekly alcohol binges. Neutrophil infiltration, neutrophil extracellular traps (NETs) and fibrosis were evaluated...
May 22, 2024: Gut
https://read.qxmd.com/read/38777572/puerarin-alleviates-atherosclerosis-via-the-inhibition-of-prevotella-copri-and-its-trimethylamine-production
#5
JOURNAL ARTICLE
Ze-Hua Li, Jun Weng, Jing Yan, Yu-Hong Zeng, Qing-Yun Hao, Hua-Fang Sheng, Yong-Quan Hua, Yi Deng, Zhan-Peng Wen, Zhi-Ye Wu, Gong-Hui Li, Xing Li, Rong-Huan Tan, Jia-Cheng Ding, Ping-Zhen Yang, Hong-Wei Zhou, Zhuang Li
OBJECTIVE: Puerarin (PU) is a natural compound that exhibits limited oral bioavailability but has shown promise in the treatment of atherosclerosis (AS). However, the precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate the effects of PU and its mechanisms in mitigating AS in both mice and humans. DESIGN: The impact of PU on AS was examined in ApoE -/- mice fed a high-fat diet (HFD) and in human patients with carotid artery plaque...
May 22, 2024: Gut
https://read.qxmd.com/read/38777571/heavy-arch-from-inflammatory-bowel-diseases-to-metabolic-disorders
#6
REVIEW
Timon E Adolph, Moritz Meyer, Almina Jukic, Herbert Tilg
BACKGROUND: Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle and related dietary habits over the last decades. Both disease entities are characterised by complex and heterogeneous clinical spectra linked to distinct symptoms and organ systems which, on a first glimpse, do not have many commonalities in clinical practice. However, experimental studies indicate a common backbone of inflammatory mechanisms in metabolic diseases and gut inflammation, and emerging clinical evidence suggests an intricate interplay between metabolic disorders and IBD...
May 22, 2024: Gut
https://read.qxmd.com/read/38754955/intron-mediated-enhancement-of-spink1-expression-for-pancreatitis-therapy
#7
LETTER
Gergő Berke, Miklós Sahin-Tóth
No abstract text is available yet for this article.
May 16, 2024: Gut
https://read.qxmd.com/read/38754954/eosinophils-a-novel-therapeutic-target-to-promote-liver-regeneration-in-acute-liver-injury
#8
JOURNAL ARTICLE
Hong-Min Ni, Amaya Lopez-Pascual
No abstract text is available yet for this article.
May 16, 2024: Gut
https://read.qxmd.com/read/38754953/the-peptidoglycan-recognition-protein-1-confers-immune-evasive-properties-on-pancreatic-cancer-stem-cells
#9
JOURNAL ARTICLE
Juan Carlos López-Gil, Susana García-Silva, Laura Ruiz-Cañas, Diego Navarro, Adrián Palencia-Campos, Antonio Giráldez-Trujillo, Julie Earl, Jorge Dorado, Gonzalo Gómez-López, Ana Monfort-Vengut, Sonia Alcalá, Matthias M Gaida, Sandra García-Mulero, Pablo Cabezas-Sáinz, Sandra Batres-Ramos, Emma Barreto, Patricia Sánchez-Tomero, Mireia Vallespinós, Leah Ambler, Meng-Lay Lin, Alexandra Aicher, Ana García García de Paredes, Carolina de la Pinta, Alfonso Sanjuanbenito, Ignacio Ruz-Caracuel, Mercedes Rodríguez-Garrote, Carmen Guerra, Alfredo Carrato, Guillermo de Cárcer, Laura Sánchez, César Nombela-Arrieta, Elisa Espinet, Víctor Javier Sanchez-Arevalo Lobo, Christopher Heeschen, Bruno Sainz
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) has limited therapeutic options, particularly with immune checkpoint inhibitors. Highly chemoresistant 'stem-like' cells, known as cancer stem cells (CSCs), are implicated in PDAC aggressiveness. Thus, comprehending how this subset of cells evades the immune system is crucial for advancing novel therapies. DESIGN: We used the KPC mouse model ( LSL-KrasG12D/+ ; LSL-Trp53R172H/+ ; Pdx-1-Cre ) and primary tumour cell lines to investigate putative CSC populations...
May 16, 2024: Gut
https://read.qxmd.com/read/38749670/beyond-traditional-subtyping-a-multilayered-genomic-perspective-on-colorectal-cancer
#10
LETTER
Shaida Ouladan, Elias Orouji
No abstract text is available yet for this article.
May 15, 2024: Gut
https://read.qxmd.com/read/38744443/targeting-squalene-epoxidase-restores-anti-pd-1-efficacy-in-metabolic-dysfunction-associated-steatohepatitis-induced-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Jun Wen, Xiang Zhang, Chi Chun Wong, Yating Zhang, Yasi Pan, Yunfei Zhou, Alvin Ho-Kwan Cheung, Yali Liu, Fenfen Ji, Xing Kang, Dabin Liu, Jun Yu
OBJECTIVE: Squalene epoxidase (SQLE) promotes metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma (MASH-HCC), but its role in modulating the tumour immune microenvironment in MASH-HCC remains unclear. DESIGN: We established hepatocyte-specific Sqle transgenic (tg) and knockout mice, which were subjected to a choline-deficient high-fat diet plus diethylnitrosamine to induce MASH-HCC. SQLE function was also determined in orthotopic and humanised mice...
May 13, 2024: Gut
https://read.qxmd.com/read/38740509/human-milk-oligosaccharide-2-fucosyllactose-protects-against-high-fat-diet-induced-obesity-by-changing-intestinal-mucus-production-composition-and-degradation-linked-to-changes-in-gut-microbiota-and-faecal-proteome-profiles-in-mice
#12
JOURNAL ARTICLE
Paola Paone, Dimitris Latousakis, Romano Terrasi, Didier Vertommen, Ching Jian, Valentina Borlandelli, Francesco Suriano, Malin E V Johansson, Anthony Puel, Caroline Bouzin, Nathalie M Delzenne, Anne Salonen, Nathalie Juge, Bogdan I Florea, Giulio G Muccioli, Herman Overkleeft, Matthias Van Hul, Patrice D Cani
OBJECTIVE: To decipher the mechanisms by which the major human milk oligosaccharide (HMO), 2'-fucosyllactose (2'FL), can affect body weight and fat mass gain on high-fat diet (HFD) feeding in mice. We wanted to elucidate whether 2'FL metabolic effects are linked with changes in intestinal mucus production and secretion, mucin glycosylation and degradation, as well as with the modulation of the gut microbiota, faecal proteome and endocannabinoid (eCB) system. RESULTS: 2'FL supplementation reduced HFD-induced obesity and glucose intolerance...
May 13, 2024: Gut
https://read.qxmd.com/read/38724220/novel-il-4-hb-egf-dependent-crosstalk-between-eosinophils-and-macrophages-controls-liver-regeneration-after-ischaemia-and-reperfusion-injury
#13
JOURNAL ARTICLE
Yang Yang, Long Xu, Constance Atkins, Lily Kuhlman, Jie Zhao, Jong-Min Jeong, Yankai Wen, Nicolas Moreno, Kang Ho Kim, Yu A An, Fenfen Wang, Steve Bynon, Vincenzo Villani, Bin Gao, Frank Brombacher, Raymond Harris, Holger K Eltzschig, Elizabeth Jacobsen, Cynthia Ju
OBJECTIVE: Previous studies indicate that eosinophils are recruited into the allograft following orthotopic liver transplantation and protect from ischaemia reperfusion (IR) injury. In the current studies, we aim to explore whether their protective function could outlast during liver repair. DESIGN: Eosinophil-deficient mice and adoptive transfer of bone marrow-derived eosinophils (bmEos) were employed to investigate the effects of eosinophils on tissue repair and regeneration after hepatic IR injury...
May 9, 2024: Gut
https://read.qxmd.com/read/38724219/landscape-of-the-gut-mycobiome-dynamics-during-pregnancy-and-its-relationship-with-host-metabolism-and-pregnancy-health
#14
JOURNAL ARTICLE
Yuanqing Fu, Wanglong Gou, Ping Wu, Yuwei Lai, Xinxiu Liang, Ke Zhang, Menglei Shuai, Jun Tang, Zelei Miao, Jieteng Chen, Jiaying Yuan, Bin Zhao, Yunhaonan Yang, Xiaojuan Liu, Yayi Hu, An Pan, Xiong-Fei Pan, Ju-Sheng Zheng
OBJECTIVE: The remodelling of gut mycobiome (ie, fungi) during pregnancy and its potential influence on host metabolism and pregnancy health remains largely unexplored. Here, we aim to examine the characteristics of gut fungi in pregnant women, and reveal the associations between gut mycobiome, host metabolome and pregnancy health. DESIGN: Based on a prospective birth cohort in central China (2017 to 2020): Tongji-Huaxi-Shuangliu Birth Cohort, we included 4800 participants who had available ITS2 sequencing data, dietary information and clinical records during their pregnancy...
May 9, 2024: Gut
https://read.qxmd.com/read/38724218/diagnostic-dilemma-sudden-onset-of-multiple-skin-lesions-in-a-patient-with-intestinal-disease
#15
JOURNAL ARTICLE
Cong Dai, Yu-Hong Huang
No abstract text is available yet for this article.
May 9, 2024: Gut
https://read.qxmd.com/read/38719336/comprehensive-single-cell-analysis-deciphered-microenvironmental-dynamics-and-immune-regulator-olfactomedin-4-in-pathogenesis-of-gallbladder-cancer
#16
JOURNAL ARTICLE
Huisi He, Shuzhen Chen, Yong Yu, Zhecai Fan, Youwen Qian, Yaping Dong, Yuting Song, Caiming Zhong, Xiaojuan Sun, Qiqi Cao, Shiyao Li, Weihan Huang, Wenxin Li, Mingzhu Zhuang, Jinxian Yang, Xianming Wang, Jiaqian Wang, Dongfang Wu, Hongyang Wang, Wen Wen
OBJECTIVE: Elucidating complex ecosystems and molecular features of gallbladder cancer (GBC) and benign gallbladder diseases is pivotal to proactive cancer prevention and optimal therapeutic intervention. DESIGN: We performed single-cell transcriptome analysis on 230 737 cells from 15 GBCs, 4 cholecystitis samples, 3 gallbladder polyps, 5 gallbladder adenomas and 16 adjacent normal tissues. Findings were validated through large-scale histological assays, digital spatial profiler multiplexed immunofluorescence (GeoMx), etc...
May 6, 2024: Gut
https://read.qxmd.com/read/38719335/perplexing-case-of-abdominal-pain-with-eosinophilia-and-fasciitis
#17
JOURNAL ARTICLE
Robert Sean O'Neill, Logan Gardner, Anthony Kelleher, Roger Pamphlett, Laila Girgis, Alina Stoita
No abstract text is available yet for this article.
May 6, 2024: Gut
https://read.qxmd.com/read/38697774/postprandial-symptoms-in-disorders-of-gut-brain-interaction-and-their-potential-as-a-treatment-target
#18
REVIEW
Alexander C Ford, Heidi M Staudacher, Nicholas J Talley
Postprandial, or meal-related, symptoms, such as abdominal pain, early satiation, fullness or bloating, are often reported by patients with disorders of gut-brain interaction, including functional dyspepsia (FD) or irritable bowel syndrome (IBS). We propose that postprandial symptoms arise via a distinct pathophysiological process. A physiological or psychological insult, for example, acute enteric infection, leads to loss of tolerance to a previously tolerated oral food antigen. This enables interaction of both the microbiota and the food antigen itself with the immune system, causing a localised immunological response, with activation of eosinophils and mast cells, and release of inflammatory mediators, including histamine and cytokines...
May 2, 2024: Gut
https://read.qxmd.com/read/38697773/concerns-about-instrumental-variable-selection-for-biological-effect-versus-uptake-of-proton-pump-inhibitors-in-mendelian-randomisation-analysis
#19
LETTER
Shuai Yuan, Susanna C Larsson, Dipender Gill, Stephen Burgess
No abstract text is available yet for this article.
May 2, 2024: Gut
https://read.qxmd.com/read/38697772/diagnostic-yield-from-symptomatic-gastroscopy-in-the-uk-british-society-of-gastroenterology-analysis-using-data-from-the-national-endoscopy-database
#20
JOURNAL ARTICLE
David Robert Beaton, Linda Sharp, Liya Lu, Nigel J Trudgill, Mo Thoufeeq, Brian D Nicholson, Peter Rogers, James Docherty, Anna Jenkins, Allan John Morris, Thomas Rösch, Matthew D Rutter
OBJECTIVE: This national analysis aimed to calculate the diagnostic yield from gastroscopy for common symptoms, guiding improved resource utilisation. DESIGN: A cross-sectional study was conducted of diagnostic gastroscopies between 1 March 2019 and 29 February 2020 using the UK National Endoscopy Database. Mixed-effect logistic regression models were used, incorporating random (endoscopist) and fixed (symptoms, age and sex) effects on two dependent variables (endoscopic cancer; Barrett's oesophagus (BO) diagnosis)...
May 2, 2024: Gut
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