journal
https://read.qxmd.com/read/36944480/ten-reasons-gastroenterologists-and-hepatologists-should-be-treating-obesity
#1
REVIEW
Michael Camilleri, Emad M El-Omar
No abstract text is available yet for this article.
March 21, 2023: Gut
https://read.qxmd.com/read/36944479/australian-inflammatory-bowel-disease-consensus-statements-for-preconception-pregnancy-and-breast-feeding
#2
JOURNAL ARTICLE
Robyn Laube, Christian P Selinger, Cynthia H Seow, Britt Christensen, Emma Flanagan, Debra Kennedy, Reme Mountifield, Sean Seeho, Antonia Shand, Astrid-Jane Williams, Rupert W Leong
OBJECTIVE: Because pregnancy outcomes tend to be worse in women with inflammatory bowel disease (IBD) than in those without, we aimed to update consensus statements that guide the clinical management of pregnancy in patients with IBD. DESIGN: A multidisciplinary working group was established to formulate these consensus statements. A modified RAND/UCLA appropriateness method was used, consisting of a literature review, online voting, discussion meeting and a second round of voting...
March 21, 2023: Gut
https://read.qxmd.com/read/36922017/quest-for-immunological-biomarkers-in-the-management-of-chb-patients
#3
JOURNAL ARTICLE
Antonio Bertoletti, Nina Le Bert
No abstract text is available yet for this article.
March 15, 2023: Gut
https://read.qxmd.com/read/36918265/comprehensive-molecular-phenotyping-of-arid1a-deficient-gastric-cancer-reveals-pervasive-epigenomic-reprogramming-and-therapeutic-opportunities
#4
JOURNAL ARTICLE
Chang Xu, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M Flores, Melissa Pool Pizzi, Atsushi Okabe, Angie Lay Keng Tan, Feng Zhu, Vikrant Kumar, Xiaoyin Lu, Ana Morales Benitez, Benedict Shi Xiang Lian, Haoran Ma, Shamaine Wei Ting Ho, Kalpana Ramnarayanan, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Siti Aishah Binte Abdul Ghani, Su Ting Tay, Xuewen Ong, Ming Hui Lee, Yu Amanda Guo, Hassan Ashktorab, Duane Smoot, Shang Li, Anders Jacobsen Skanderup, Michael A Beer, Roger Sik Yin Foo, Joel Shi Hao Wong, Kaushal Sanghvi, Wei Peng Yong, Raghav Sundar, Atsushi Kaneda, Shyam Prabhakar, Pawel Karol Mazur, Jaffer A Ajani, Khay Guan Yeoh, Jimmy Bok-Yan So, Patrick Tan
OBJECTIVE: Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A -specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss. DESIGN: Genomic profiling of GC patients including a Singapore cohort (>200 patients) was performed to derive mutational signatures of ARID1A inactivation across molecular subtypes. Single-cell transcriptomic profiles of ARID1A -mutated GCs were analysed to examine tumour microenvironmental changes arising from ARID1A loss...
March 14, 2023: Gut
https://read.qxmd.com/read/36898830/post-covid-19-irritable-bowel-syndrome
#5
LETTER
Cong Dai, Yu-Hong Huang, Min Jiang
No abstract text is available yet for this article.
March 10, 2023: Gut
https://read.qxmd.com/read/36898829/new-insights-into-an-old-paradigm-why-iga-accumulates-in-alcoholic-liver-disease-and-what-could-be-its-role
#6
JOURNAL ARTICLE
Dragos Ciocan, Williams Turpin
No abstract text is available yet for this article.
March 10, 2023: Gut
https://read.qxmd.com/read/36889906/interactive-enhancer-hubs-ihubs-mediate-transcriptional-reprogramming-and-adaptive-resistance-in-pancreatic-cancer
#7
JOURNAL ARTICLE
Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel mechanistic approaches to overcome or prevent resistance in PDAC. DESIGN: We used in vitro and in vivo models of resistant PDAC and integrated epigenomic, transcriptomic, nascent RNA and chromatin topology data. We identified a JunD-driven subgroup of enhancers, called interactive hubs (iHUBs), which mediate transcriptional reprogramming and chemoresistance in PDAC...
March 8, 2023: Gut
https://read.qxmd.com/read/36882194/-family-based-strategy-for-helicobacter-pylori-infection-screening-an-efficient-alternative-to-test-and-treat-strategy
#8
LETTER
Jiafeng Zhang, Yuchen Deng, Chang Liu, Huiquan Wang, Heifei Ren, Sai Chen, Lei Chen, Bin Shi, Lin Zhou
No abstract text is available yet for this article.
March 7, 2023: Gut
https://read.qxmd.com/read/36882193/significant-underestimation-of-preventive-effects-in-colorectal-cancer-screening-trial
#9
LETTER
Thomas Heisser, Michael Hoffmeister, Hermann Brenner
No abstract text is available yet for this article.
March 7, 2023: Gut
https://read.qxmd.com/read/36878683/robust-sars-cov-2-antibody-and-t-cell-immunity-following-three-covid-19-vaccine-doses-in-inflammatory-bowel-disease-patients-receiving-anti-tnf-or-alternative-treatments
#10
LETTER
Eva Zhang, Thi H O Nguyen, Lilith F Allen, Lukasz Kedzierski, Louise C Rowntree, So Young Chang, Wuji Zhang, Jennifer R Habel, Isabelle J Foo, Tejas Menon, Jeni Mitchell, Rupert W Leong, Katherine Bond, Deborah A Williamson, Katherine Kedzierka, Britt Christensen
No abstract text is available yet for this article.
March 6, 2023: Gut
https://read.qxmd.com/read/36878682/sucrase-isomaltase-genotype-and-response-to-a-starch-reduced-and-sucrose-reduced-diet-in-ibs-d-patients
#11
LETTER
Andreea Zamfir-Taranu, Britt-Sabina Löscher, Diab M Husein, Abdullah Hoter, Koldo Garcia-Etxebarria, Usune Etxeberria, Lucía Gayoso, Gabriele Mayr, Clara Nilholm, Rita J Gustafsson, Oliver Ozaydin, Tenghao Zheng, Cristina Esteban-Blanco, Isotta Bozzarelli, Ferdinando Bonfiglio, Sandra Rizk, Andre Franke, Luis Bujanda, Hassan Y Naim, Bodil Ohlsson, Mauro D'Amato
No abstract text is available yet for this article.
March 6, 2023: Gut
https://read.qxmd.com/read/36878681/empiric-use-of-standard-triple-therapy-in-helicobacter-pylori-eradication-does-not-require-readjustment-in-the-clarithromycin-resistance-cut-off-point
#12
LETTER
Peter Malfertheiner, Francis Megraud, Theodore Rokkas, Javier P Gisbert
No abstract text is available yet for this article.
March 6, 2023: Gut
https://read.qxmd.com/read/36868846/atrophic-autoimmune-gastritis-a-muddled-or-misguided-core-concept-compromises-our-overall-comprehension-of-the-problem
#13
LETTER
Massimo Rugge, Robert M Genta, Peter Malfertheiner, David Y Graham
No abstract text is available yet for this article.
March 3, 2023: Gut
https://read.qxmd.com/read/36868845/diagnostic-dilemma-a-patient-with-diarrhoea
#14
JOURNAL ARTICLE
Nikhita Sane, Ashley Bloom
No abstract text is available yet for this article.
March 3, 2023: Gut
https://read.qxmd.com/read/36849227/gastric-cancer-risk-in-autoimmune-gastritis-evidence-versus-opinion
#15
LETTER
Massimo Rugge, Robert M Genta, Peter Malfertheiner, David Y Graham
No abstract text is available yet for this article.
February 27, 2023: Gut
https://read.qxmd.com/read/36849226/patient-selection-for-urgent-endoscopic-retrograde-cholangio-pancreatography-by-endoscopic-ultrasound-in-predicted-severe-acute-biliary-pancreatitis-apec-2-a-multicentre-prospective-study
#16
JOURNAL ARTICLE
Nora D Hallensleben, Pauline M C Stassen, Nicolien J Schepers, Marc G Besselink, Marie-Paule G F Anten, Olaf J Bakker, Thomas L Bollen, David W da Costa, Sven M van Dijk, Hendrik M van Dullemen, Marcel G W Dijkgraaf, Brechje van Eijck, Casper H J van Eijck, Willemien Erkelens, Nicole S Erler, Paul Fockens, Erwin-Jan M van Geenen, Janneke van Grinsven, Wouter L Hazen, Robbert A Hollemans, Jeanin E van Hooft, Jeroen M Jansen, Frank J G M Kubben, Sjoerd D Kuiken, Alexander C Poen, Rutger Quispel, Rogier J de Ridder, Tessa E H Römkens, Erik J Schoon, Matthijs P Schwartz, Tom C J Seerden, Xavier J N M Smeets, B W Marcel Spanier, Adriaan C I T L Tan, Willem J Thijs, Robin Timmer, Devica S Umans, Niels G Venneman, Robert C Verdonk, Frank P Vleggaar, Wim van de Vrie, Roy L J van Wanrooij, Ben J Witteman, Hjalmar C van Santvoort, Stefan A W Bouwense, Marco J Bruno
OBJECTIVE: Routine urgent endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic biliary sphincterotomy (ES) does not improve outcome in patients with predicted severe acute biliary pancreatitis. Improved patient selection for ERCP by means of endoscopic ultrasonography (EUS) for stone/sludge detection may challenge these findings. DESIGN: A multicentre, prospective cohort study included patients with predicted severe acute biliary pancreatitis without cholangitis...
February 27, 2023: Gut
https://read.qxmd.com/read/36828627/sdcbp-promotes-pancreatic-cancer-progression-by-preventing-yap1-from-%C3%AE-trcp-mediated-proteasomal-degradation
#17
JOURNAL ARTICLE
Jing Liu, Weiwei Bai, Tianxing Zhou, Yongjie Xie, Bo Yang, Jingyan Sun, Yifei Wang, Xueyang Li, Xupeng Hou, Ziyun Liu, Danqi Fu, Jingrui Yan, Wenna Jiang, Kaili Zhao, Bodong Zhou, Shuai Yuan, Yu Guo, Hongwei Wang, Antao Chang, Song Gao, Lei Shi, Chongbiao Huang, Shengyu Yang, Jihui Hao
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal tumour with limited treatment options. Here, we identified syndecan binding protein (SDCBP), also known as syntenin1, as a novel targetable factor in promoting PDAC tumour progression. We also explored a therapeutic strategy for suppressing SDCBP expression. DESIGN: We used samples from patients with PDAC, human organoid models, LSL-KrasG12D/+mice, LSL-Trp53R172H/+ and Pdx1-Cre (KPC) mouse models, and PDX mouse models...
February 24, 2023: Gut
https://read.qxmd.com/read/36828626/definition-of-age-dependent-reference-values-for-the-diameter-of-the-common-bile-duct-and-pancreatic-duct-on-mrcp-a-population-based-cross-sectional-cohort-study
#18
JOURNAL ARTICLE
Georg Beyer, Florian Kasprowicz, Anke Hannemann, Ali Aghdassi, Patrick Thamm, Henry Volzke, Markus M Lerch, Jens-Peter Kühn, Julia Mayerle
OBJECTIVE: Changes of the pancreaticobiliary ducts herald disease. Magnetic resonance cholangiopancreatography (MRCP) allows accurate duct visualisation. Data on reliable upper reference ranges are missing. DESIGN: Cross-sectional whole body MRI data from the population-based Study of Health in Pomerania were analysed. The width of the common bile duct (CBD) and the pancreatic duct (PD) was determined. We aimed to describe the distribution of physiological duct diameters on MRCP in a population of healthy subjects and to identify factors influencing duct size...
February 24, 2023: Gut
https://read.qxmd.com/read/36810144/antibiotic-use-and-inflammatory-bowel-disease-number-needed-to-harm
#19
LETTER
Jonas F Ludvigsson
No abstract text is available yet for this article.
February 21, 2023: Gut
https://read.qxmd.com/read/36792357/microrna-223-a-key-regulator-of-liver-tumour-microenvironment
#20
JOURNAL ARTICLE
Matias A Avila
No abstract text is available yet for this article.
February 15, 2023: Gut
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