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Mayo Clinic Proceedings

Courtney E Harris, Claire L Jansson-Knodell, Abinash Virk
No abstract text is available yet for this article.
February 9, 2019: Mayo Clinic Proceedings
Jeff R Anderson, Thomas D Y Chung, Leon Clark, Jennifer A Weis, Andrew J Danielsen, Sundeep Khosla, Gregory J Gores, Andrew D Badley
The Office of Translation to Practice (OTP) is housed in the Center for Clinical and Translational Sciences at Mayo Clinic. Established in 2015, the office was tasked with developing and managing novel tools, mechanisms, and processes to facilitate and accelerate the translation of products, such as drugs, biological agents, and medical devices, into practice. Since its inception, the OTP is credited with creating valuable services through several strategic alliances and active scientific and project management involvement...
February 6, 2019: Mayo Clinic Proceedings
Dalene M Bott-Kitslaar, Robert D McBane, Ana I Casanegra, Damon E Houghton, David A Froehling, Danielle T Vlazny, Aneel A Ashrani, David O Hodge, Emily R Vargas, Matthew A Bartlett, Rayya A Saadiq, Paul R Daniels, Raymond C Shields, Charles J Lenz, Teresa R Lang, Waldemar E Wysokinski
OBJECTIVE: To compare the clinical efficacy and safety of apixaban with those of rivaroxaban for the treatment of acute venous thromboembolism (VTE). PATIENTS AND METHODS: Consecutive patients enrolled in the Mayo Thrombophilia Clinic Registry (between March 1, 2013, and January 30, 2018) and treated with apixaban or rivaroxaban for acute VTE were followed forward in time. The primary efficacy outcome was VTE recurrence. The primary safety outcome was major bleeding; the second safety outcome was clinically relevant nonmajor bleeding (CRNMB); and the third was a composite of major bleeding or CRNMB...
February 6, 2019: Mayo Clinic Proceedings
Manuel B Braga Neto, Paul V Viscuse, Karna K Sundsted
No abstract text is available yet for this article.
February 6, 2019: Mayo Clinic Proceedings
Rhanderson Cardoso, Roger S Blumenthal, Stephen Kopecky, Francisco Lopez-Jimenez, Seth S Martin
The 2013 American College of Cardiology/American Heart Association guideline on the treatment of blood cholesterol was a landmark document guiding health care professionals around the globe on how to administer lipid-lowering therapies. Those guidelines were primarily focused on statin therapy benefit groups. The writing committee found insufficient evidence for specific low-density lipoprotein cholesterol (LDL-C) treatment targets. There have been many important updates in the lipid literature since the publication of that document...
February 6, 2019: Mayo Clinic Proceedings
Surbhi Sidana, Nidhi Tandon, Peter A Brady, Martha Grogan, Morie A Gertz, Angela Dispenzieri, Grace Lin, David Dingli, Francis K Buadi, Martha Q Lacy, Prashant Kapoor, Wilson I Gonsalves, Eli Muchtar, Rahma Warsame, Shaji K Kumar, Taxiarchis V Kourelis
OBJECTIVE: To evaluate the prognostic impact of Holter findings in patients with light chain amyloidosis. PATIENTS AND METHODS: We evaluated 239 patients in whom light chain amyloidosis was diagnosed from January 1, 2010, through December 31, 2015, who underwent 24-hour Holter monitoring. RESULTS: Holter testing was done before stem cell transplant evaluation in 183 of the 239 patients (76.6%) and at diagnosis in 50 (20.9%). Holter findings were nonsustained ventricular tachycardia (NSVT) in 60 patients (25...
February 1, 2019: Mayo Clinic Proceedings
Ian C Chang, Angela Dispenzieri, Christopher G Scott, Grace Lin, Allan S Jaffe, Kyle W Klarich, Martha Grogan
OBJECTIVE: To determine the utility of the serum free light chain (FLC) assay for routine screening of light chain amyloidosis (AL) in patients with heart failure. PATIENTS AND METHODS: We studied consecutive new patients referred to the Heart Failure Clinic who had the FLC assay performed for routine screening at Mayo Clinic's campus in Rochester, Minnesota, from January 1, 2011, through December 31, 2015. An FLC ratio between 0.26 and 1.65 was considered normal...
February 1, 2019: Mayo Clinic Proceedings
Shirin Ghanavatian, Christopher S Wie, Rhonda S Low, Nan Zhang, Jordan M Montoya, Gurman Singh Dhaliwal, David L Swanson
Postherpetic neuralgia (PHN) is the most common complication of varicella zoster virus (VZV) reactivation and a cause of considerable physical and psychosocial morbidity. No known treatment effectively prevents the development of PHN in patients with VZV reactivation. In this study, our objective was to evaluate the efficacy of premedication with gabapentin for reducing the risk of PHN in patients with diabetic and nondiabetic neuropathy. We retrospectively searched the electronic health records of patients with diabetic and nondiabetic neuropathy treated with gabapentin at Mayo Clinic before diagnosis of VZV reactivation...
February 1, 2019: Mayo Clinic Proceedings
Erin F Barreto, Andrew D Rule, M Hassan Murad, Kianoush B Kashani, John C Lieske, Patricia J Erwin, James M Steckelberg, Ognjen Gajic, Joel M Reid, Sandra L Kane-Gill
Serum cystatin C has been proposed as a kidney biomarker to inform drug dosing. We conducted a systematic review to synthesize available data for the association between serum cystatin C and drug pharmacokinetics, dosing, and clinical outcomes in adults (≥18 years). PubMed, Ovid MEDLINE, Ovid EMBASE, EBSCO CINAHL, and Scopus were systematically searched from 1946 to September 2017 to identify candidate studies. Studies of cystatin C as a predictor for acute kidney injury or for management of contrast-associated acute kidney injury were excluded...
January 31, 2019: Mayo Clinic Proceedings
Divya Padmanabhan Menon, Neal M Patel
No abstract text is available yet for this article.
January 31, 2019: Mayo Clinic Proceedings
Jane F Reckelhoff
Available online January 31, 2019. The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at
January 31, 2019: Mayo Clinic Proceedings
Hasan Ahmad Hasan Albitar, Eva M Carmona
No abstract text is available yet for this article.
January 31, 2019: Mayo Clinic Proceedings
Robert A Kyle, Dirk R Larson, Paul J Kurtin, Shaji Kumar, James R Cerhan, Terry M Therneau, S Vincent Rajkumar, Celine M Vachon, Angela Dispenzieri
OBJECTIVE: To determine the incidence of immunoglobulin light chain amyloidosis (AL amyloidosis) in a strictly defined geographic area from 1990 through 2015. PATIENTS AND METHODS: We searched a computerized database for the records of all Olmsted County, Minnesota, residents with a diagnosis of AL amyloidosis from January 1, 1990, through December 31, 2015. In addition, records of all residents with a mention of amyloidosis were obtained from the Rochester Epidemiology Project, which contains the medical records of Mayo Clinic and Olmsted Medical Group...
January 31, 2019: Mayo Clinic Proceedings
Claudia L Zeballos-Palacios, Ian G Hargraves, Peter A Noseworthy, Megan E Branda, Marleen Kunneman, Bruce Burnett, Michael R Gionfriddo, Christopher J McLeod, Haeshik Gorr, Juan Pablo Brito, Victor M Montori
Patient-centered care requires that treatments respond to the problematic situation of each patient in a manner that makes intellectual, emotional, and practical sense, an achievement that requires shared decision making (SDM). To implement SDM in practice, tools-sometimes called conversation aids or decision aids-are prepared by collating, curating, and presenting high-quality, comprehensive, and up-to-date evidence. Yet, the literature offers limited guidance for how to make evidence support SDM. Herein, we describe our approach and the challenges encountered during the development of Anticoagulation Choice, a conversation aid to help patients with atrial fibrillation and their clinicians jointly consider the risk of thromboembolic stroke and decide whether and how to respond to this risk with anticoagulation...
January 11, 2019: Mayo Clinic Proceedings
Kimberly R Johnson, Daniel A Schupack, Abinash Virk
No abstract text is available yet for this article.
January 9, 2019: Mayo Clinic Proceedings
Sara Y Tartof, Lei Qian, In-Lu Amy Liu, Hung Fu Tseng, Lina S Sy, Rulin C Hechter, Bruno J Lewin, Steven J Jacobsen
OBJECTIVE: To determine whether influenza vaccination during hospitalization increases health care utilization, fever, and infection evaluations postdischarge. PATIENTS AND METHODS: This retrospective cohort study conducted at Kaiser Permanente Southern California included patients aged 6 months or older hospitalized in a Kaiser Permanente Southern California facility with admission and discharge dates between September 1 and March 31 of the following calendar year, from 2011 to 2014...
January 3, 2019: Mayo Clinic Proceedings
Heidi T May, Donald L Lappé, Kirk U Knowlton, Joseph B Muhlestein, Jeffrey L Anderson, Benjamin D Horne
OBJECTIVE: To apply the practical parsimonious modeling method of the Intermountain Mortality Risk Score in a primary care environment to predict chronic disease (ChrD) onset. PATIENTS AND METHODS: Primary care patients free of ChrD (women: n=98,711; men: n=45,543) were evaluated to develop (70% [n=95,882] of patients) and validate (the other 30% [n=48,372]) the sex-specific Intermountain Chronic Disease Risk Score (ICHRON) if seen initially between January 1, 2003, and December 31, 2005...
December 18, 2018: Mayo Clinic Proceedings
Junaid Nizamuddin, Atul Gupta, Vijal Patel, Mohammed Minhaj, Sarah L Nizamuddin, Ariel L Mueller, Heba Naseem, Avery Tung, Sarosh Rana, Sajid Shahul
OBJECTIVE: To study the association between hypertensive diseases of pregnancy and immediate postpartum development of heart failure in a large national database. PATIENTS AND METHODS: Using the 2013 to 2014 National Readmissions Database, which covered admissions from January 1 through September 30 in years 2013 and 2014, we examined 90-day readmission rates in parturients with a diagnosis of hypertensive disease of pregnancy who were discharged after delivery...
December 18, 2018: Mayo Clinic Proceedings
Isabel Mira-Avendano, Andy Abril, Charles D Burger, Paul F Dellaripa, Aryeh Fischer, Michael B Gotway, Augustine S Lee, Joyce S Lee, Eric L Matteson, Eunhee S Yi, Jay H Ryu
Lung involvement in connective tissue diseases is associated with substantial morbidity and mortality, most commonly in the form of interstitial lung disease, and can occur in any of these disorders. Patterns of interstitial lung disease in patients with connective tissue disease are similar to those seen in idiopathic interstitial pneumonias, such as idiopathic pulmonary fibrosis. It may be difficult to distinguish between the 2 ailments, particularly when interstitial lung disease presents before extrapulmonary manifestations of the underlying connective tissue disease...
December 14, 2018: Mayo Clinic Proceedings
Daniele Pastori, Pasquale Pignatelli, Danilo Menichelli, Francesco Violi, Gregory Y H Lip
OBJECTIVE: To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathway. PATIENTS AND METHODS: This prospective single-center cohort study included 907 consecutive patients with nonvalvular AF on vitamin K antagonists from February 2008 to December 2016...
December 11, 2018: Mayo Clinic Proceedings
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