journal
https://read.qxmd.com/read/36946293/sensitivity-analysis-of-eq-5d-3l-index-scores-in-terms-of-discriminative-and-known-groups-validity-in-sle-introducing-adequate-health-state
#1
JOURNAL ARTICLE
Nicole Hua, Alvaro Gomez, Julius Lindblom, Sharzad Emamikia, Yvonne Enman, David Grannas, Emelie Heintz, Malin Regardt, Ioannis Parodis
OBJECTIVES: To investigate the ability of different EQ-5D-3L index scores to discriminate between verum drug and placebo (discriminant validity) as well as between responders and non-responders (known-groups validity) in the SLE patient population of two phase III clinical trials of belimumab. METHODS: Data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (N = 1684), which both showed superiority of belimumab to placebo, were utilised...
March 22, 2023: Rheumatology
https://read.qxmd.com/read/36944272/factors-impacting-women-s-advancement-to-positions-on-editorial-boards-of-rheumatology-journals
#2
JOURNAL ARTICLE
Jessica Day, Pavel Ovseiko, Tayyeba Khursheed, Renil Titus, Vikas Agarwal, Laura Coates, Latika Gupta
No abstract text is available yet for this article.
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36944271/metabolic-and-inflammatory-profiles-define-phenotypes-with-clinical-relevance-in-female-knee-osteoarthritis-patients-with-joint-effusion
#3
JOURNAL ARTICLE
Joan Calvet, María García-Manrique, Antoni Berenguer-Llergo, Cristóbal Orellana, Silvia Garcia Cirera, Maria Llop, Carlos Galisteo Lencastre, Marta Arévalo, Cristina Aymerich, Rafael Gómez, Néstor Albiñana Giménez, Jordi Gratacó
OBJECTIVES: Osteoarthritis has been the subject of abundant research in the last years with limited translation to the clinical practice, probably due to the disease's high heterogeneity. In this study, we aimed to identify different phenotypes in Knee osteoarthritis (KOA) patients with joint effusion based on their metabolic and inflammatory profiles. METHODS: A non-supervised strategy based on Statistical and Machine Learning methods was applied to 45 parameters measured on 168 female KOA patients with persistent joint effusion, consecutively recruited at our hospital after a monographic OA outpatient visit...
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36944270/n-glycan-in-the-monoclonal-acpa-ccp-ab1-the-variable-region-promotes-the-exacerbation-of-experimental-arthritis
#4
JOURNAL ARTICLE
Masatoshi Kawataka, Kazuhisa Ouhara, Eiji Kobayashi, Koichiro Shinoda, Kazuyuki Tobe, Ryousuke Fujimori, Noriyoshi Mizuno, Eiji Sugiyama, Tatsuhiko Ozawa, Hiroyuki Kishi
OBJECTIVES: The variable region of most ACPA IgG molecules in the serum of RA patients carries N-glycan (N-glycanV). To analyze the pathogenicity of N-glycanV of ACPAs, we analyzed the pathogenicity of a monoclonal ACPA, CCP-Ab1, with or without N-glycanV, which had been isolated from a patient with RA. METHODS: CCP-Ab1 with no N-glycosylation site in the variable region (CCP-Ab1 N-rev) was generated and antigen binding, the effect on in vitro differentiation of osteoclasts from bone marrow mononuclear cells of autoimmune arthritis-prone SKG mice (the cell size of TRAP+ cells and bone resorption capacity), and the in vivo effect on the onset or exacerbation of autoimmune arthritis in SKG mice were evaluated in comparison to glycosylated CCP-Ab1...
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36944263/focal-facial-myositis-a-paraneoplastic-syndrome
#5
JOURNAL ARTICLE
Tiago Beirão, Beatriz Samões, Diogo Fonseca, Catarina Rua, Flávio Costa, Romana Vieira, Joana Aleixo, Taciana Videira, Cristina Ferreira, Henrique Coelho, Patrícia Pinto
No abstract text is available yet for this article.
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36943383/lenalidomide-for-systemic-lupus-erythematosus-with-refractory-cutaneous-eruptions
#6
JOURNAL ARTICLE
Xiaoqi Wang, Mengtao Li, Xiaofeng Zeng, Qian Wang
No abstract text is available yet for this article.
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36943379/etanercept-originator-versus-etanercept-biosimilar-for-the-treatment-of-rheumatoid-arthritis-as-a-first-biologic-results-from-the-bsrbr-ra
#7
JOURNAL ARTICLE
Lianne Kearsley-Fleet, Aasiyah Rokad, Man-Fung Tsoi, Sizheng Steven Zhao, Mark Lunt, Kath Watson, Kimme L Hyrich
OBJECTIVES: Etanercept biosimilars show comparable efficacy to their originators among biologic-naïve patients with RA in RCTs. Nationwide guidelines have obligated prescribing of etanercept biosimilars from 2016 resulting in significant cost-savings. This analysis aimed to compare the effectiveness of etanercept originator versus etanercept biosimilar amongst biologic-naïve RA patients treated in routine clinical-practice in the UK. METHODS: Biologic-naïve RA patients starting etanercept in the BSRBR-RA cohort study from 2010 were included...
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36943375/course-and-predictors-of-work-productivity-in-gout-results-from-the-nor-gout-longitudinal-2-year-treat-to-target-study
#8
JOURNAL ARTICLE
Till Uhlig, Lars F Karoliussen, Joe Sexton, Sella Aarrestad Provan, Tore K Kvien, Espen A Haavardsholm, Hilde Berner Hammer
OBJECTIVES: In patients with gout there is a lack of longitudinal studies on the course of work productivity. We explored longitudinal changes in and predictors of work productivity over 2 years. METHODS: Patients in the NOR-Gout observational study with a recent gout flare and serum urate (sUA) >360 µmol/l attended tight-control visits during escalating urate lowering therapy according to a treat-to target strategy. From the Work Productivity and Activity Impairment Questionnaire (WPAI) scores for work productivity and activity impairment were assessed over 2 years together with the Beliefs about Medicines Questionnaire (BMQ) and a variety of demographic and clinical variables...
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36943374/e-learning-and-practical-performance-in-musculoskeletal-ultrasound-a-multicenter-randomized-study
#9
JOURNAL ARTICLE
Stine Maya Dreier Carstensen, Søren Andreas Just, Marie Velander, Lars Konge, Martin Slusarczyk Hubel, Thiusius Rajeeth Savarimuthu, Mogens Pfeiffer Jensen, Mikkel Østergaard, Lene Terslev
OBJECTIVES: To examine the effect of pre-course e-learning on residents' practical performance in musculoskeletal ultrasound (MSUS). METHODS: Multicentre, randomized controlled study following the CONSORT statement. Residents with no or little MSUS experience were randomized to either an e-learning group or a traditional group. One week before a 2-day face-to-face MSUS course, the e-learning group received access to an interactive platform consisting of online lectures, assignments, and practical instruction videos aligned with the content of the course...
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36943365/comparisons-of-sle-das-and-sledai-2k-and-classification-of-disease-activity-based-on-the-sle-das-with-reference-to-patient-reported-outcomes
#10
JOURNAL ARTICLE
Akira Onishi, Hideaki Tsuji, Yudai Takase, Yuto Nakakubo, Takeshi Iwasaki, Tomohiro Kozuki, Tsuneyasu Yoshida, Mirei Shirakashi, Hideo Onizawa, Ryosuke Hiwa, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Masao Tanaka, Akio Morinobu
OBJECTIVES: Although the systemic lupus erythematosus disease activity score (SLE-DAS) and its definitions to classify disease activity have been recently developed to overcome the drawbacks of the SLE Disease Activity Index 2000 (SLEDAI-2K), the performance of the SLE-DAS for patient-reported outcomes (PROs) has not been fully examined. We aimed to compare SLE-DAS with SLEDAI-2K and validate the classifications of disease activity based on SLE-DAS in terms of PROs. METHODS: We assessed generic quality of life (QoL) using the Medical Outcome Survey 36-Item Short-Form Health Survey (SF-36), disease-specific QoL using the Lupus Patient-Reported Outcome tool (LupusPRO), burden of symptoms using the SLE Symptom Checklist (SSC), patient global assessment (PtGA), and physician global assessment (PhGA)...
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36943357/comment-on-glucocorticoids-prescribing-practices-in-systemic-sclerosis-an-analysis-of-the-eustar-database
#11
JOURNAL ARTICLE
Jacopo Ciaffi, Sophie I E Liem, Nina M van Leeuwen, Cornelia F Allaart, Tom W J Huizinga, Jeska K de Vries-Bouwstra
No abstract text is available yet for this article.
March 21, 2023: Rheumatology
https://read.qxmd.com/read/36929927/to-vaccinate-or-not-to-vaccinate-on-vaccine-hesitancy-decreases-in-rheumatic-diseases
#12
JOURNAL ARTICLE
Marco Krasselt
No abstract text is available yet for this article.
March 17, 2023: Rheumatology
https://read.qxmd.com/read/36929924/quantitative-interstitial-lung-disease-scores-in-idiopathic-inflammatory-myopathies-longitudinal-changes-and-clinical-implications
#13
JOURNAL ARTICLE
Jina Yeo, Soon Ho Yoon, Ju Yeon Kim, Jeong Seok Lee, Eun Young Lee, Jin Mo Goo, Lila Pourzand, Jonathan G Goldin, Grace-Hyun J Kim, You-Jung Ha
OBJECTIVES: To investigate computer-aided quantitative scores from high-resolution CT (HRCT) images and determine their longitudinal changes and clinical significance in patients with idiopathic inflammatory myopathies (IIMs)-related interstitial lung disease (IIMs-ILD). METHODS: The clinical data and HRCT images of 80 patients with IIMs who underwent serial HRCT scans at least twice were retrospectively analysed. Quantitative ILD (QILD) scores (%) were calculated as the sum of the extent of lung fibrosis, ground-glass opacity, and honeycombing...
March 17, 2023: Rheumatology
https://read.qxmd.com/read/36929923/performance-of-the-2016-acr-eular-myositis-response-criteria-in-adult-dermatomyositis-polymyositis-therapeutic-trials-and-consensus-profiles
#14
JOURNAL ARTICLE
Didem Saygin, Hanna Kim, Christian Douglas, Brian Erman, Jesse Wilkerson, John A McGrath, Chester V Oddis, Ingrid E Lundberg, Anthony A Amato, Ignacio García-De La Torre, Hector Chinoy, David Fiorentino, Lorinda Chung, Yeong-Wook Song, Frederick W Miller, Nicolino Ruperto, Jiri Vencovsky, Rohit Aggarwal, Lisa G Rider
OBJECTIVE: The ACR-EULAR myositis response criteria (MRC) were developed as a composite measure using absolute percentage change in six core set measures (CSMs). We aimed to further validate the MRC by assessing the contribution of each CSM, frequency of strength versus extramuscular activity improvement, representation of patient-reported outcome measures (PROM), and frequency of CSM worsening. METHODS: Data from adult dermatomyositis/polymyositis patients in the rituximab (n = 147), etanercept (n = 14), and abatacept (n = 19) trials, and consensus patient profiles (n = 232) were evaluated...
March 17, 2023: Rheumatology
https://read.qxmd.com/read/36929918/performance-of-the-2016-acr-eular-myositis-response-criteria-in-juvenile-dermatomyositis-therapeutic-trials-and-consensus-profiles
#15
JOURNAL ARTICLE
Hanna Kim, Didem Saygin, Christian Douglas, Jesse Wilkerson, Brian Erman, Angela Pistorio, John A McGrath, Ann M Reed, Chester V Oddis, Claudia Bracaglia, Annet van Royen-Kerkhof, Blanca Bica, Pavla Dolezalova, Virginia P L Ferriani, Berit Flato, Ana G Bernard-Medina, Troels Herlin, Frederick W Miller, Jiri Vencovsky, Nicolino Ruperto, Rohit Aggarwal, Lisa G Rider
OBJECTIVES: The 2016 ACR-EULAR Response Criteria for juvenile dermatomyositis (JDM) was developed as a composite measure with differential weights of six core set measures (CSMs) to calculate a Total Improvement Score (TIS). We assessed the contribution of each CSM, representation of muscle-related and patient-reported CSMs towards improvement, and frequency of CSM worsening across myositis response criteria (MRC) categories in validation of MRC. METHODS: Data from JDM patients in the Rituximab in Myositis trial (n = 48), PRINTO JDM trial (n = 139), and consensus patient profiles (n = 273) were included...
March 17, 2023: Rheumatology
https://read.qxmd.com/read/36929914/prevalence-and-clinical-associations-of-ultrasound-confirmed-enthesitis-in-systemic-lupus-erythematosus
#16
JOURNAL ARTICLE
Filippo Fagni, Alessandra Bettiol, Elena Silvestri, Roberto Fedi, Adalgisa Palermo, Maria Letizia Urban, Ruggero Mazzotta, Danilo Malandrino, Federica Bello, Irene Mattioli, David Simon, Gerardo Di Scala, Georg Schett, Domenico Prisco, Giacomo Emmi
OBJECTIVES: To assess the prevalence of ultrasound (US)-confirmed enthesitis in a cohort of patients with systemic lupus erythematosus (SLE) and to analyze the clinical associations to enthesitis during the course of SLE. METHODS: In a retrospective analysis of the SLE cohort of the Lupus Unit of the Careggi University Hospital, US examinations of SLE patients presenting with tender and/or swollen joints were retrieved to assess the presence of enthesitis. Patients with US-proven enthesitis were compared with SLE controls with tender and/or swollen joints who showed no US-evidence of enthesitis...
March 17, 2023: Rheumatology
https://read.qxmd.com/read/36929913/adult-onset-still-s-disease-complicated-by-guillain-barr%C3%A3-syndrome
#17
JOURNAL ARTICLE
Nicola Farina, Daniel Arroyo-Sánchez, Corrado Campochiaro, Lorenzo Dagna, Alessandro Tomelleri
No abstract text is available yet for this article.
March 17, 2023: Rheumatology
https://read.qxmd.com/read/36928927/correction-to-standardized-nailfold-capillaroscopy-in-children-with-rheumatic-diseases-a-worldwide-study
#18
(no author information available yet)
No abstract text is available yet for this article.
March 16, 2023: Rheumatology
https://read.qxmd.com/read/36919777/the-diagnostic-value-of-urinary-n-terminal-fragment-of-titin-for-skeletal-muscle-damage-in-idiopathic-inflammatory-myopathy
#19
JOURNAL ARTICLE
Jianhong Sun, Sheng Ye, Geng Yin, Qibing Xie
OBJECTIVES: N-terminal fragment of titin (N-titin) is a marker of sarcomere damage in striated muscles, however, its value in patients with IIM is unclear. This study aimed to investigate the diagnostic value of N-titin for skeletal muscle damage in patients with IIM. METHODS: Urine samples from 62 patients with IIM, 59 patients with other CTD diseases, and 29 healthy controls were collected to detect N-titin by ELISA assays. Clinical features and laboratory data were all included in logistic regression analysis to obtain the independent predictive factor for skeletal muscle damage...
March 15, 2023: Rheumatology
https://read.qxmd.com/read/36919770/mortality-estimates-and-excess-mortality-in-rheumatoid-arthritis
#20
JOURNAL ARTICLE
Rachel J Black, Susan Lester, Joanna Tieu, Premarani Sinnathurai, Claire Barrett, Rachelle Buchbinder, Marissa Lassere, Lyn March, Susanna M Proudman, Catherine L Hill
OBJECTIVES: To determine long-term (20 year) survival in RA patients enrolled in the Australian Rheumatology Association Database (ARAD). METHODS: ARAD patients with RA and data linkage consent who were diagnosed from 1995 onwards were included. Death data were obtained through linkage to the Australian National Death Index. Results were compared with age, gender and calendar year matched Australian population mortality rates.Analysis included both the standardised mortality ratio (SMR) and relative survival models...
March 15, 2023: Rheumatology
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