journal

Rheumatology

journal
https://read.qxmd.com/read/32215644/inverse-gottron-s-sign-in-anti-mda5-antibody-associated-dermatomyositis
#1
Siddharth Jain, Aman Sharma
No abstract text is available yet for this article.
March 26, 2020: Rheumatology
https://read.qxmd.com/read/32215624/hyperspectral-imaging-for-skin-assessment-in-systemic-sclerosis-a-pilot-study
#2
Yi-Ming Chen, Kuo-Lung Lai, Hsin-Hua Chen, Wen-Nan Huang, Ching-Tsai Lin, Wen-Cheng Chao, Jun-Peng Chen, Yu-Wen Fu, Hsian-Min Chen, Ping-Wing Lui
OBJECTIVE: Hyperspectral imaging (HSI) is a novel technology for obtaining quantitative measurements from transcutaneous spatial and spectral information. In patients with SSc, the severity of skin tightness is associated with internal organ involvement. However, clinical assessment using the modified Rodnan skin score is highly variable and there are currently no universal standardized protocols. This study aimed to compare the ability to differentiate between SSc patients and healthy controls using skin scores, ultrasound and HSI...
March 26, 2020: Rheumatology
https://read.qxmd.com/read/32211780/biomarker-panels-may-be-superior-over-single-molecules-in-prediction-of-renal-flares-in-systemic-lupus-erythematosus-an-exploratory-study
#3
Serena Fasano, Luciana Pierro, Alessia Borgia, Melania Alessia Coscia, Ranieri Formica, Laura Bucci, Antonella Riccardi, Francesco Ciccia
OBJECTIVE: Recent evidence suggests that some urinary biomarkers, namely Vascular Cell Adhesion Molecule-1 (VCAM-1), Intercellular Adhesion Molecule-1 (ICAM-1), Monocyte Chemoattractant Protein 1 (MCP-1), Neutrophil Gelatinase Associated Lipocalcin and Lipocalin-type Prostaglandin D-Synthetase (L-PGDS), might discriminate SLE patients with ongoing renal activity from those with stable disease. The objective of this study was to assess the role of these markers in predicting renal flares in comparison with conventional biomarkers and to derive a biomarker panel which may improve diagnostic accuracy...
March 24, 2020: Rheumatology
https://read.qxmd.com/read/32211770/gastrointestinal-involvement-in-adult-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura-updated-picture-from-a-french-multicentre-and-retrospective-series-of-260-cases
#4
Alexandra Audemard-Verger, Evangéline Pillebout, Zahir Amoura, Patrice Cacoub, Noémie Jourde-Chiche, Bertrand Lioger, Nihal Martis, Guillaume Moulis, Etienne Rivière, Aurélie Baldolli, Charlotte Girard, Julie Goutte, Noémie Le Gouellec, Loïc Raffray, Geoffrey Urbanski, Sébastien Sanges, Francois Maurier, Eric Thervet, Achille Aouba, Loïc Guillevin, Francois Maillot, Benjamin Terrier
OBJECTIVES: To describe the clinical presentation, treatments and prognosis of gastrointestinal (GI) involvement in adult IgA vasculitis (IgAV). METHODS: Data from 260 adults with IgAV included in a French multicentre retrospective survey were analysed. Presentation and outcomes of patients with (GI+) and without (GI-) GI involvement were compared. RESULTS: One hundred and thirty-seven (53%) patients had GI involvement. Initial manifestations were abdominal pain in 99%, intestinal bleeding in 31%, diarrhoea in 26% and acute surgical abdomen in only 4%...
March 24, 2020: Rheumatology
https://read.qxmd.com/read/32206811/splicing-factor-srsf1-controls-t-cell-homeostasis-and-its-decreased-levels-are-linked-to-lymphopenia-in-systemic-lupus-erythematosus
#5
Takayuki Katsuyama, Ignacio Juarez Martin-Delgado, Suzanne M Krishfield, Vasileios C Kyttaris, Vaishali R Moulton
OBJECTIVE: Lymphopenia is a frequent clinical manifestation and risk factor for infections in SLE, but the underlying mechanisms are not fully understood. We previously identified novel roles for the RNA-binding protein serine arginine-rich splicing factor 1 (SRSF1) in the control of genes involved in signalling and cytokine production in human T cells. SRSF1 is decreased in T cells from patients with SLE and associates with severe disease. Because SRSF1 controls the expression of apoptosis-related genes, we hypothesized that SRSF1 controls T cell homeostasis and, when reduced, leads to lymphopenia...
March 24, 2020: Rheumatology
https://read.qxmd.com/read/32206792/diagnosis-of-fibromyalgia-comparison-of-the-2011-2016-acr-and-aapt-criteria-and-validation-of-the-modified-fibromyalgia-assessment-status
#6
Fausto Salaffi, Marco Di Carlo, Sonia Farah, Fabiola Atzeni, Dan Buskila, Jacob N Ablin, Winfried Häuser, Piercarlo Sarzi-Puttini
OBJECTIVE: To compare the concordance of the three diagnostic criteria, respectively the 2011 ACR criteria (ACR 2011 Cr), the ACR 2016 criteria (ACR 2016 Cr) and the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION)-APS Pain Taxonomy criteria (AAPT Cr), and to explore the performance of an additional set of criteria, the modified Fibromyalgia Assessment Status (FAS 2019 modCr), in the diagnosis of FM syndrome. METHODS: Consecutive patients with chronic widespread pain, referred by the primary care setting, underwent rheumatologic assessment that established the presence or not of FM and were investigated through the four sets of proposed criteria...
March 24, 2020: Rheumatology
https://read.qxmd.com/read/32191334/joint-trajectories-of-disease-activity-and-physical-and-mental-health-related-quality-of-life-in-an-inception-lupus-cohort
#7
William Fung, Lily Siok Hoon Lim, George Tomlinson, Lisa Engel, Jiandong Su, Juan Pablo Diaz-Martinez, Zahi Touma
OBJECTIVES: To examine for latent patterns of SLE disease activity trajectories that associate with specific latent patterns of health-related quality of life (HRQoL; Medical Outcomes Study Short Form-36), and to determine baseline predictors of class membership. METHODS: In this retrospective longitudinal inception cohort of 222 SLE adults over 10 years, trajectories of three outcomes were studied jointly: Short Form-36 physical (PCS) and mental (MCS) component summaries and adjusted mean SLEDAI-2000 (AMS)...
March 19, 2020: Rheumatology
https://read.qxmd.com/read/32182369/a-molecular-taxonomy-for-systemic-autoimmune-rheumatic-diseases-sards-learning-lessons-from-oncology
#8
John A Reynolds, Ian N Bruce
No abstract text is available yet for this article.
March 17, 2020: Rheumatology
https://read.qxmd.com/read/32182367/tocilizumab-treatment-for-polyarteritis-nodosa
#9
Martin Krusche, Nikolas Ruffer, Udo Schneider, Marco Meyer, Gerd Burmester, Ina Kötter
No abstract text is available yet for this article.
March 17, 2020: Rheumatology
https://read.qxmd.com/read/32182366/the-effect-of-reducing-systemic-inflammation-on-serum-urate
#10
David E W Pietsch, Paul Kubler, Philip C Robinson
No abstract text is available yet for this article.
March 17, 2020: Rheumatology
https://read.qxmd.com/read/32182362/regional-variations-in-adverse-event-reporting-rates-and-acr-responses-in-placebo-standard-of-care-arms-of-rheumatoid-arthritis-trials
#11
Daniel Keebler, Edmond Teng, Jenny Chia, Joshua Galanter, Jodie Peake, Katie Tuckwell
OBJECTIVE: Clinical trials are increasingly globalized, and adverse event (AE) rates and treatment responses may differ by geographical region. This study assessed regional differences in AE reporting rates and ACR response rates (ACR20/50) in patients with RA who received placebo/standard-of-care treatment in clinical trials. METHODS: Patients from the placebo arms of 7 RA trials in the TransCelerate Biopharma Inc database were grouped into 5 geographical regions (Asia, Latin America, Russian Federation and Eastern Europe [RFEE], USA, and Western Europe)...
March 17, 2020: Rheumatology
https://read.qxmd.com/read/32176771/association-between-celiac-disease-and-systemic-lupus-erythematosus-a-mendelian-randomization-study
#12
Jun Inamo
No abstract text is available yet for this article.
March 16, 2020: Rheumatology
https://read.qxmd.com/read/32176299/comment-on-what-is-the-best-treatment-for-early-rheumatoid-arthritis
#13
Patrick Verschueren, Veerle Stouten, René Westhovens, Diederik De Cock, Sofia Pazmino
No abstract text is available yet for this article.
March 16, 2020: Rheumatology
https://read.qxmd.com/read/32176298/the-value-of-the-squeeze-test-for-detection-of-subclinical-synovitis-in-patients-with-arthralgia-suspicious-for-progression-to-ra
#14
Fenne Wouters, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
No abstract text is available yet for this article.
March 16, 2020: Rheumatology
https://read.qxmd.com/read/32176297/comment-on-pregnancy-and-undifferentiated-connective-tissue-disease-outcome-and-risk-of-flare-in-100-pregnancies-reply
#15
Dina Zucchi, Chiara Tani, Francesca Monacci, Elena Elefante, Linda Carli, Alice Parma, Chiara Stagnaro, Francesco Ferro, Sabrina Gori, Francesca Anna Letizia Strigini, Marta Mosca
No abstract text is available yet for this article.
March 16, 2020: Rheumatology
https://read.qxmd.com/read/32176284/comment-on-pregnancy-and-undifferentiated-connective-tissue-disease-outcome-and-risk-of-flare-in-100-pregnancies
#16
Ruoning Ni, Liangjing Lu
No abstract text is available yet for this article.
March 16, 2020: Rheumatology
https://read.qxmd.com/read/32163586/lupus-hand
#17
Arghya Chattopadhyay, Aman Sharma
No abstract text is available yet for this article.
March 12, 2020: Rheumatology
https://read.qxmd.com/read/32163584/immunological-characteristics-and-possible-pathogenic-role-of-urinary-cd11c-macrophages-in-lupus-nephritis
#18
Jihye Kim, Ji Hye Jeong, Jaehyung Jung, Hanwool Jeon, Seungjoo Lee, Joon Seo Lim, Heounjeong Go, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
OBJECTIVES: Kidney-infiltrating immune cells can contribute to the pathogenesis of lupus nephritis (LN). We investigated the immunological characteristics of CD11c+ macrophages and their functions associated with the pathogenesis of LN. METHODS: CD11c+ macrophages were examined in the urine samples of patients with LN. Phenotypic markers and pro-inflammatory cytokine expression levels were analysed by flow cytometry. To determine the origin of urinary macrophages, peripheral monocytes were treated with sera from patients with systemic lupus erythematosus (SLE)...
March 12, 2020: Rheumatology
https://read.qxmd.com/read/32163583/comment-on-subclassifying-anca-associated-vasculitis-a-unifying-view-of-disease-spectrum-reply
#19
Alfred Mahr, Ulrich Specks, David Jayne
No abstract text is available yet for this article.
March 12, 2020: Rheumatology
https://read.qxmd.com/read/32163582/comment-on-subclassifying-anca-associated-vasculitis-a-unifying-view-of-disease-spectrum
#20
Peter Lamprecht, Antje Müller, Veronique Witko-Sarsat, Loic Guillevin
No abstract text is available yet for this article.
March 12, 2020: Rheumatology
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