journal
https://read.qxmd.com/read/37725366/do-the-features-of-juvenile-psoriatic-arthritis-change-according-to-age-a-comprehensive-evaluation-of-the-pera-research-group-registry
#1
JOURNAL ARTICLE
Şerife Gül Karadağ, Taner Coskuner, Fatma Gül Demirkan, Hafize Emine Sonmez, Semanur Ozdel, Mustafa Çakan, Gulcin Otar Yener, Kubra Ozturk, Ferhat Demir, Betül Sozeri, Nuray Aktay Ayaz
OBJECTIVES: To describe the clinical features and treatment outcomes of children with juvenile psoriatic arthritis (JPsA) and to compare the distinct patterns of the disease between early-onset and late-onset age groups. METHODS: Patients with JPsA followed regularly for at least 6 months between 2010-2020 in 7 pediatric rheumatology centers in Turkey were included in the study. The demographic features, clinical manifestations, treatment strategies, and outcomes of the patients were evaluated retrospectively...
September 19, 2023: Rheumatology
https://read.qxmd.com/read/37725361/occupational-impacts-of-early-inflammatory-arthritis-results-from-the-national-early-inflammatory-arthritis-audit
#2
JOURNAL ARTICLE
Katie Bechman, Emma Cook, Edward Alveyn, Abdullah Houssien, Martin Stevens, Mark D Russell, Maryam Adas, Paul Amlani-Hatcher, Sam Norton, Heidi Lempp, Joanna Ledingham, James Galloway, Karen Walker-Bone
OBJECTIVES: Inflammatory arthritis (IA) causes significant work disability. Studies frequently fail to report important contextual information such as employment type. Our objective was to explore work participation, by gender and occupation type in early IA. METHODS: Data are from the National Early Inflammatory Arthritis Audit between 2018 and 2020. At diagnosis, clinicians collected information on demographics, IA disease activity and working status. Participants completed patient-reported outcomes at baseline, 3- and 12-months, including occupation and Work Productivity Activity Impairment (WPAI)...
September 19, 2023: Rheumatology
https://read.qxmd.com/read/37725359/progressive-pulmonary-fibrosis-and-its-impact-on-survival-in-systemic-sclerosis-related-interstitial-lung-disease
#3
JOURNAL ARTICLE
Kathleen Morrisroe, Dylan Hansen, Wendy Stevens, Laura Ross, Joanne Sahhar, Gene-Siew Ngian, Catherine L Hill, Lauren Host, Jennifer Walker, Susanna Proudman, Mandana Nikpour
OBJECTIVE: To describe the frequency of progressive pulmonary fibrosis (PPF) in an incident cohort of systemic sclerosis (SSc) related interstitial lung disease (ILD) and its impact on survival. METHODS: Incident ILD was defined as the new development of characteristic fibrotic changes on chest HRCT scan. PPF was defined as per the 2022 American Thoracic Society. Determinants of PPF were identified using generalised estimating equations. Impact on survival was analysed using accelerated failure time regression modelling...
September 19, 2023: Rheumatology
https://read.qxmd.com/read/37725357/significant-gastrointestinal-unmet-needs-in-patients-with-systemic-sclerosis-insights-from-a-large-international-patient-survey
#4
JOURNAL ARTICLE
Giulia Bandini, Alessia Alunno, Barbara Ruaro, Ilaria Galetti, Michael Hughes, Zsuzsanna H McMahan
No abstract text is available yet for this article.
September 19, 2023: Rheumatology
https://read.qxmd.com/read/37725356/can-efficacy-and-safety-data-from-clinical-trials-of-rituximab-in-ra-be-extrapolated-insights-from-1984-patients-from-the-air-pr-registry
#5
JOURNAL ARTICLE
Yann Nguyen, Xavier Mariette, Jacques E Gottenberg, Michele Iudici, Jacques Morel, Olivier Vittecoq, Arnaud Constantin, Rene-Marc Flipo, Thierry Schaeverbeke, Jean Sibilia, Philippe Ravaud, Raphaël Porcher, Raphaèle Seror
OBJECTIVES: To investigate whether the efficacy and safety data from drug-registration trials can be extrapolated to real-life RA patients receiving RTX. METHODS: The AIR-PR registry is a French multicentre, prospective cohort of RA patients treated with RTX in a real-life setting. We compared treatment responses at 12 months and serious AEs between eligible and non-eligible patients, by retrieving the eligibility criteria of the three rituximab-registration trials...
September 19, 2023: Rheumatology
https://read.qxmd.com/read/37725352/patterns-and-determinants-of-response-to-novel-therapies-in-juvenile-and-adult-onset-polyarthritis
#6
JOURNAL ARTICLE
Clément Triaille, Pierre Quartier, Lien De Somer, Patrick Durez, Bernard Lauwerys, Patrick Verschueren, Peter C Taylor, Carine Wouters
Biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) have revolutionized the management of multiple rheumatic inflammatory conditions. Amongst these, polyarticular juvenile idiopathic arthritis (pJIA) and rheumatoid arthritis (RA) display similarities in terms of disease pathophysiology and response pattern to b/tsDMARDs. Indeed, therapeutic efficacy of novel targeted drugs is variable among individual patients, in both RA and pJIA. Mechanisms and determinants of this heterogeneous response are diverse and complex, such that development of true "precision"-medicine strategies has proven highly challenging...
September 19, 2023: Rheumatology
https://read.qxmd.com/read/37725337/old-paradigms-and-new-concepts-in-familial-mediterranean-fever-fmf-an-update-2023
#7
JOURNAL ARTICLE
Eldad Ben-Chetrit
Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent attacks of fever and polyserositis. Its first description as a new entity was published by Siegal in 1945. Colchicine has been the treatment of choice for this disease since 1972. Significant progress has been made over the years in understanding FMF's clinical features, diagnosis, mode of inheritance, pathogenesis, and therapeutic approach. However, many old paradigms related to FMF have proven inaccurate, leading to the emergence of new concepts that provide more precise insights...
September 19, 2023: Rheumatology
https://read.qxmd.com/read/37713434/tolerability-and-comparative-effectiveness-of-tnf-il-17-and-il-23-p19-inhibitors-in-psoriatic-arthritis-a-target-trial-emulation-study
#8
JOURNAL ARTICLE
Zara R Stisen, Sabrina M Nielsen, Marie Skougaard, Mette Mogensen, Tanja Schjødt Jørgensen, Lene Dreyer, Maarten de Wit, Robin Christensen, Lars Erik Kristensen
OBJECTIVES: To compare tolerability and effectiveness of two different classes of biological Disease-Modifying Anti-Rheumatic Drugs (bDMARDs; interleukin (IL)-17- and IL-23(p19) inhibitors) relative to tumour necrosis factor inhibitors (TNFi) regarding the drug survival rates and treatment outcomes in patients with psoriatic arthritis (PsA). METHODS: We emulated a target trial on comparative effectiveness using observational data from a prospective cohort study based on the Parker Institute's PsA cohort - the PIPA cohort...
September 15, 2023: Rheumatology
https://read.qxmd.com/read/37713430/the-chest-ct-signs-for-pulmonary-veno-occlusive-disease-correlate-with-pulmonary-haemodynamics-in-systemic-sclerosis
#9
JOURNAL ARTICLE
Haruka Moriya, Masaru Kato, Ryo Hisada, Keita Ninagawa, Maria Tada, Kodai Sakiyama, Mitsutaka Yasuda, Michihito Kono, Yuichiro Fujieda, Olga Amengual, Yasuka Kikuchi, Ichizo Tsujino, Takahiro Sato, Tatsuya Atsumi
OBJECTIVE: Pulmonary arterial hypertension associated with systemic sclerosis (PAH-SSc) sometimes accompanies pulmonary veno-occlusive disease (PVOD). We aimed to reveal the relation between clinical signs of PVOD and severing of pulmonary vasculopathy in SSc. METHODS: This study comprised 52 consecutive SSc patients who had pulmonary haemodynamic abnormalities (mPAP > 20 mmHg, PVR > 2 W.U. or PAWP > 15 mmHg)...
September 15, 2023: Rheumatology
https://read.qxmd.com/read/37707539/cancer-screening-before-treatments-in-rheumatoid-arthritis-lights-and-shadows
#10
JOURNAL ARTICLE
Michele Lorenzon, Alen Zabotti, Lorenzo Cereser
No abstract text is available yet for this article.
September 14, 2023: Rheumatology
https://read.qxmd.com/read/37707533/development-and-implementation-of-a-guide-to-ppie-early-integration-into-research-proposals-in-a-multi-disciplinary-consortium
#11
JOURNAL ARTICLE
Richard Beesley, Freya Luling Feilding, Elizabeth C Rosser, Stephanie J W Shoop-Worrall, Alyssia McNeece, Zoe Wanstall, Kimme Hyrich, Lucy R Wedderburn
No abstract text is available yet for this article.
September 14, 2023: Rheumatology
https://read.qxmd.com/read/37699005/socioeconomic-deprivation-and-its-relationship-with-worse-disease-outcomes-in-rheumatoid-arthritis-impact-beyond-traditional-risk-factors
#12
JOURNAL ARTICLE
Sytske Anne Bergstra
No abstract text is available yet for this article.
September 12, 2023: Rheumatology
https://read.qxmd.com/read/37698987/comparison-of-clinical-features-between-patients-with-anti-synthetase-syndrome-and-dermatomyositis-results-from-the-myonet-registry
#13
JOURNAL ARTICLE
Ryan Malcolm Hum, James B Lilleker, Janine A Lamb, Alexander G S Oldroyd, Guochun Wang, Lucy R Wedderburn, Louise P Diederichsen, Jens Schmidt, Maria Giovanna Danieli, Paula Oakley, Zoltan Griger, Thuy Nguyen Thi Phuong, Chanakya Kodishala, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan L De Bleecker, Britta Maurer, Liza McCann, Nicolo Pipitone, Neil McHugh, Robert Paul New, William E Ollier, Niels Steen Krogh, Jiri Vencovsky, Ingrid E Lundberg, Hector Chinoy
OBJECTIVES: To compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations, and malignancy, between adults with anti-synthetase syndrome (ASyS) and dermatomyositis (DM). METHODS: Using data regarding adults from the MYONET registry, a cohort of DM patients with anti-Mi2/-TIF1ɣ/-NXP2/-SAE/-MDA5 autoantibodies, and a cohort of ASyS patients with anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified...
September 12, 2023: Rheumatology
https://read.qxmd.com/read/37698986/atypical-posterior-reversible-encephalopathy-syndrome-pres-as-onset-of-giant-cell-arteritis-gca
#14
JOURNAL ARTICLE
Marco Del Carria, Massimo Del Panta, Paola Parronchi
No abstract text is available yet for this article.
September 12, 2023: Rheumatology
https://read.qxmd.com/read/37698983/extra-osseous-manifestations-in-chronic-recurrent-multifocal-osteomyelitis-a-retrospective-study
#15
JOURNAL ARTICLE
Marie Robert, Anna Giolito, Heloise Reumaux, Linda Rossi-Semerano, Claire Guillemin, Louis Biarrotte, Damia Leguevaques, Alexandre Belot, Agnès Duquesne, Cécile Frachette, Audrey Laurent, Marine Desjonquères, Jean-Paul Larbre, Caroline Galeotti, Isabelle Koné-Paut, Perrine Dusser
OBJECTIVES: Extra-osseous (EO) manifestations are poorly characterized in chronic recurrent multifocal osteomyelitis (CRMO). This study aimed to further define the frequency, characteristics and treatment of EO events in CRMO and whether different phenotypes can be distinguished and benefit from special management. METHODS: This multicentre retrospective study included CRMO patients followed in several paediatric rheumatology departments in France, between 2015 and 2022...
September 12, 2023: Rheumatology
https://read.qxmd.com/read/37698981/three-uba1-clones-for-a-unique-vexas-syndrome
#16
JOURNAL ARTICLE
Benjamin Podvin, Nathalie Cleenewerck, Olivier Nibourel, Alice Marceau-Renaut, Pauline Roynard, Claude Preudhomme, Nicolas Duployez, Louis Terriou
No abstract text is available yet for this article.
September 12, 2023: Rheumatology
https://read.qxmd.com/read/37695305/hand-joints-without-radiographic-osteoarthritis-maintain-their-joint-space-width-over-4-years-despite-what-s-happening-elsewhere-in-the-hand
#17
JOURNAL ARTICLE
Jeffrey B Driban, Nhung Vo, Jeff Duryea, Lena F Schaefer, Ida K Haugen, Charles B Eaton, Mary B Roberts, Bing Lu, Timothy McAlindon
OBJECTIVES: We aimed to determine if hand osteoarthritis is characterized by systemic cartilage loss by assessing if radiographically normal joints had greater joint space width (JSW) loss during four years in hands with incident or prevalent osteoarthritis elsewhere in the hand compared with hands without osteoarthritis. METHODS: We used semi-automated software to measure JSW in the distal and proximal interphalangeal joints of 3,368 participants in the Osteoarthritis Initiative who had baseline and 48-month hand radiographs...
September 11, 2023: Rheumatology
https://read.qxmd.com/read/37695303/successful-switching-from-mepolizumab-to-dupilumab-in-a-patient-with-egpa-in-remission-phase-and-persistent-nasal-polyposis
#18
JOURNAL ARTICLE
Marco Caminati, Elena Scarpieri, Matteo Maule, Patrick Pinter, Michele Schiappoli, Rachele Vaia, Gianenrico Senna
No abstract text is available yet for this article.
September 11, 2023: Rheumatology
https://read.qxmd.com/read/37695290/the-risk-of-major-adverse-cardiovascular-events-in-patients-with-systemic-sclerosis-a-nationwide-population-based-cohort-study
#19
JOURNAL ARTICLE
Tsai-Hung Yen, Yun-Wen Chen, Tsu-Yi Hsieh, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen, Hsin-Hua Chen
OBJECTIVE: To assess the incidence and risk factors of major adverse cardiovascular events (MACE) in patients with systemic sclerosis (SSc). METHODS: We conducted a nationwide, population-based, cohort study using Taiwan's National Health Insurance Research Database. We performed propensity score matching (PSM) using a 1:2 ratio, resulting in inclusion of 1,379 patients with SSc and 2,758 non-SSc individuals in the analysis. We assessed the association between SSc and MACE using the multivariable Cox proportional hazard regression model with adjustment of time-dependent covariates and investigated risk factors of MACE in patients with SSc, shown as adjusted hazard ratios (aHRs) with 95% confidence intervals (CI)...
September 11, 2023: Rheumatology
https://read.qxmd.com/read/37688559/the-tophus-impact-questionnaire-tiq-20-responsiveness-to-change-during-urate-lowering-therapy
#20
JOURNAL ARTICLE
Cindy Cao, Greg Gamble, Anne Horne, Opetaia Aati, Anthony Doyle, Jill Drake, Lisa K Stamp, Nicola Dalbeth
OBJECTIVES: In 2015, the 20-item Tophus Impact Questionnaire (TIQ-20) was developed as a tophus-specific patient reported outcome measure. The aim of this study was to determine whether TIQ-20 scores change during urate-lowering therapy. METHODS: We analysed data from a two-year clinical trial of allopurinol dose escalation using a treat-to-target serum urate approach. For participants with tophaceous gout, the longest diameter of up to three index tophi was measured using Vernier calipers and the TIQ-20 was recorded at study visits...
September 9, 2023: Rheumatology
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