Aaqib Zaffar Banday, Ankur Kumar Jindal, Anit Kaur, Ruchi Saka, Amber Parwaiz, Man Updesh Singh Sachdeva, Amit Rawat
No abstract text is available yet for this article.
October 24, 2020: Rheumatology
Patrick D W Kiely, Mark E Lloyd
Ankle arthritis is a useful clinical signpost to differential diagnosis in rheumatic disease. Biomechanical features and differences in cartilage physiology compared with the knee may confer protection of the ankle joint from factors predisposing to certain arthritides. The prevalence of ankle OA is low, and usually secondary to trauma. Primary OA of the ankle should be investigated for underlying causes, especially haemochromatosis. New presentations of inflammatory mono/oligo arthritis involving the ankle are more likely due to undifferentiated arthritis or spondyloarthritis than RA, and gout over CPPD...
October 24, 2020: Rheumatology
Yushiro Endo, Tomohiro Koga, Atsushi Kawakami
No abstract text is available yet for this article.
October 24, 2020: Rheumatology
Nao Tanaka, Chikashi Terao, Yoichi Nakayama, Tsuneo Sasai, Natsuka Umezawa, Yuriko Yagyu, Kanae Ito, Ryuji Koike, Ran Nakashima, Kazuhiro Hatta, Fumitaka Mizoguchi
No abstract text is available yet for this article.
October 24, 2020: Rheumatology
Gizem Ayan, Sibel Zehra Aydin, Gezmis Kimyon, Cem Ozisler, Ilaria Tinazzi, Atalay Dogru, Ahmet Omma, Levent Kilic, Sema Yılmaz, Orhan Kucuksahin, Emel Gönüllü, Fatih Yıldız, Meryem Can, Ayşe Balkarlı, Dilek Solmaz, Ediz Dalkılıc, Ozun Bayindir, Gözde Yıldırım Çetin, Serpil Ergulu Esmen, Emine Duygu Ersozlu, Mehmet Tuncay Duruoz, Lütfi Akyol, Adem Kucuk, Cemal Bes, Muhammet Cınar, Abdulsamet Erden, Rıdvan Mercan, Sibel Bakirci, Timucin Kasifoglu, Veli Yazısız, Umut Kalyoncu
OBJECTIVES: Our aim is to understand clinical characteristics, real-life treatment strategies, outcomes of early PsA patients and determine the differences between the inception and established PsA cohorts. METHODS: PsArt-ID (Psoriatic Arthritis- International Database) is a multicentre registry. From that registry, patients with a diagnosis of PsA up to 6 months were classified as the inception cohort (n==388). Two periods were identified for the established cohort: Patients with PsA diagnosis within 5-10 years (n = 328), ≥10 years (n = 326)...
October 23, 2020: Rheumatology
William Tillett, Alexander Allen, Laura Tucker, David Chandler, Coziana Ciurtin, Charlotte Davis, Andrew Dick, Amy Foulkes, Nicola Gullick, Philip Helliwell, Deepak Jadon, Gareth Jones, Stuart Kyle, Vishnu Madhok, Neil McHugh, Andrew Parkinson, Tim Raine, Stefan Siebert, Catherine Smith, Laura C Coates
The aim of this guideline is to provide an update on evidence-based recommendations for treatment of adult patients with PsA. The previous BSR guidelines for PsA were published in 2012 and since that time, there have been many new advanced therapies licensed for PsA. This update will provide practical guidance for clinicians on the optimal selection of advanced therapies taking into account different domains of PsA (arthritis, enthesitis, dactylitis, axial disease and psoriasis) and key associated comorbidities...
October 23, 2020: Rheumatology
Thomas A Perry, Xiaotian Yang, James van Santen, Nigel K Arden, Stefan Kluzek
OBJECTIVES: Synovitis in symptomatic knee OA (KOA) is common and is associated with joint symptoms. Optimal synovial measurement on MRI is, however, unclear. Our aims were to examine the relationship between MRI measures of synovitis and knee symptoms in symptomatic KOA. METHODS: Data from a randomized, multicentre, placebo-controlled trial (UK-VIDEO) of vitamin-D therapy in symptomatic KOA were utilized. Participants reported knee symptoms using WOMAC at baseline and annually...
October 23, 2020: Rheumatology
Augusta Ortolan, Victoria Navarro-Compán, Alexandre Sepriano, Robert B M Landewé, Désirée van der Heijde, Sofia Ramiro
No abstract text is available yet for this article.
October 21, 2020: Rheumatology
Stephanie Finzel, Sandrine Jousse-Joulin, Félicie Costantino, Petra Hánová, Alojzija Hocevar, Annamaria Iagnocco, Helen Keen, Esperanza Naredo, Sarah Ohrndorf, Wolfgang A Schmidt, Maria Antonietta D'Agostino, Lene Terslev, George A Bruyn
BACKGROUND: To assess the reliability of the consensually agreed US definitions of major salivary gland lesions and the US scoring system for salivary gland assessment in patients with SS. METHODS: Nine experienced sonographers scanned and read the US images of both parotid glands (PGs) and submandibular glands (SMGs) in eight patients with primary and secondary SS in two rounds. A consensually agreed four-grade semi-quantitative scoring was applied in B-mode for morphological lesions: grade 0, normal; grade 1, mild inhomogeneity without anechoic or hypoechoic areas; grade 2, moderate inhomogeneity with focal anechoic or hypoechoic areas; grade 3, severe inhomogeneity with diffuse an- or hypoechoic areas occupying the entire gland or fibrous gland...
October 21, 2020: Rheumatology
Fulvia Ceccarelli, Carmelo Pirone, Carlo Perricone, Aikaterina Selntigia, Valeria Orefice, Viviana Antonella Pacucci, Simona Truglia, Francesca Romana Spinelli, Paola Galoppi, Cristiano Alessandri, Guido Valesini, Roberto Brunelli, Giuseppina Perrone, Fabrizio Conti
OBJECTIVE: SLE is an autoimmune disease, mainly affecting women of childbearing age, with possible impact on pregnancy. In this study, we evaluated pregnancy outcomes in all pregnant patients affected by SLE, followed in the context of a rheumatology/gynaecology multi-disciplinary team. METHODS: Since 2008, we evaluated 70 consecutive pregnancies occurring in 50 SLE patients referring to the Lupus Clinic of Sapienza University of Rome; as controls we evaluated 100 consecutive pregnancies in 100 women without autoimmune diseases...
October 21, 2020: Rheumatology
David Walker, Ade Adebajo, Marwan Bukhari
No abstract text is available yet for this article.
October 21, 2020: Rheumatology
Luca Quartuccio, Alen Zabotti, Tolinda Gallo, Salvatore De Vita, Francesca Valent
OBJECTIVES: To verify the level of adherence to the influenza vaccination program in a population of patients suffering from RA, PsA or AS undergoing immunosuppressive treatment. METHODS: Administrative databases from the Regional Health Information System of Friuli Venezia Giulia (FVG), Italy, were used. Subjects were residents in FVG, suffered from chronic inflammatory arthritis and had at least one prescription for a DMARD in the 9 months before the start of the vaccination season (from 1 October to 31 December)...
October 21, 2020: Rheumatology
Carlos Fernández-Díaz, Santos Castañeda, Rafael B Melero-González, Francisco Ortiz-Sanjuán, Antonio Juan-Mas, Carmen Carrasco-Cubero, Ivette Casafont-Solé, Alejandro Olivé, Samantha Rodríguez-Muguruza, Raquel Almodóvar-González, Raul Castellanos-Moreira, Sebastian C Rodríguez-García, Clara Aguilera-Cros, Ignacio Villa, Sergio Ordóñez-Palau, Erique Raya-Alvarez, Pilar Morales-Garrido, Clara Ojeda-García, Manuel J Moreno-Ramos, María Gema Bonilla Hernán, Iñigo Hernández Rodríguez, Mireia López-Corbeto, José L Andreu, Juan R D Jiménez de Aberásturi, Ana Ruibal-Escribano, Rosa Expósito-Molinero, Trinidad Pérez-Sandoval, Ana María López-Robles, Patricia Carreira-Delgado, Natalia Mena-Vázquez, Ana Urruticoechea-Arana, Cilia Peralta-Ginés, Luis Arboleya-Rodríguez, F Javier Narváez García, Deseada Palma-Sánchez, Evelin C Cervantes Pérez, Olga Maiz-Alonso, María N Alvarez-Rivas, Julia Fernández-Melón, Paloma Vela Casasempere, Ivan Cabezas-Rodríguez, Iván Castellvi-Barranco, Carmen González-Montagut, Juan Blanco-Madrigal, Natividad Del Val-Del Amo, María C Fito, Manuel Rodríguez-Gómez, Eva Salgado-Pérez, Blanca García-Magallón, Cristina Hidalgo-Calleja, Ruben López-Sánchez, Sabela Fernández-Aguado, Jesús C Fernández-López, Sonia Castro-Oreiro, Isabel Serrano-García, Andrea García-Valle, Susana Romero-Yuste, Lorena Expósito-Pérez, Lorena Pérez-Albadalejo, Angel García-Aparicio, Neus Quillis-Marti, José A Bernal-Vidal, Javier Loricera-García, José L Hernández, Miguel A González-Gay, Ricardo Blanco
OBJECTIVE: To assess the efficacy of abatacept (ABA) in RA patients with interstitial lung disease (ILD) (RA-ILD). METHODS: This was an observational, multicentre study of RA-ILD patients treated with at least one dose of ABA. ILD was diagnosed by high-resolution CT (HRCT). We analysed the following variables at baseline (ABA initiation), 12 months and at the end of the follow-up: Modified Medical Research Council (MMRC) scale (1-point change), forced vital capacity (FVC) or diffusion lung capacity for carbon monoxide (DLCO) (improvement or worsening ≥10%), HRCT, DAS on 28 joints evaluated using the ESR (DAS28ESR) and CS-sparing effect...
October 17, 2020: Rheumatology
Richard Conway, Elena Nikiphorou
No abstract text is available yet for this article.
October 17, 2020: Rheumatology
Nadia Elias, Naveed Sami, Kenneth Shulman, Shazia Bég
No abstract text is available yet for this article.
October 17, 2020: Rheumatology
Bin Cai, Jingyi Cai, Zhihua Yin, Xiaoyue Jiang, Chao Yao, Jianyang Ma, Zhixin Xue, Ping Miao, Qingqing Xiao, Yijun Cheng, Jialin Qin, Qiang Guo, Nan Shen, Zhizhong Ye, Bo Qu, Huihua Ding
OBJECTIVE: The long non-coding RNA plays an important role in inflammation and autoimmune diseases. The aim of this study is to screen and identify abnormally expressed lncRNAs in peripheral blood neutrophils of SLE patients as novel biomarkers and to explore the relationship between lncRNAs levels and clinical features, disease activity and organ damage. METHODS: RNA-seq technology was used to screen differentially expressed lncRNAs in neutrophils from SLE patients and healthy donors...
October 17, 2020: Rheumatology
Vinko Palada, Aisha Siddiqah Ahmed, Anders Hugo, Maja R Radojčić, Camilla I Svensson, Eva Kosek
OBJECTIVES: To characterize the expression profiles of two nuclear-encoded mitochondrial genes previously associated with chronic pain, the translocator protein (TSPO) and family with sequence similarity 173B (FAM173B), in different knee compartments from patients with painful knee OA. Also, to examine their association with the joint expression of inflammatory cytokines/chemokines and clinical symptoms. METHODS: The study was performed on 40 knee OA patients and 19 postmortem (PM) controls from which we collected the knee tissues: articular cartilage (AC), synovial membrane (SM) and subchondral bone (SB)...
October 17, 2020: Rheumatology
Shinako Miyano, Nobuaki Michihata, Ken-Ei Sada, Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Masaomi Nangaku, Hideo Yasunaga
OBJECTIVE: Whether acid suppressants [proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs)] are associated with bone fractures in patients with ANCA-associated vasculitis (AAV) treated with glucocorticoids remains unclear. This study compared PPIs with H2RAs in terms of the risk of bone fractures in patients with AAV who received in-hospital induction therapy with glucocorticoids. METHODS: We retrospectively identified 149 patients with fractures among 22 821 patients newly diagnosed with AAV in 1730 hospitals using a nationwide inpatient database from July 2010 to March 2018...
October 17, 2020: Rheumatology
Takayuki Kishi, William Warren-Hicks, Nastaran Bayat, Ira N Targoff, Adam M Huber, Michael M Ward, Lisa G Rider
OBJECTIVE: A North American registry of JDM patients was examined for frequency of and factors associated with corticosteroid discontinuation, complete clinical response and remission. METHODS: We evaluated probability of achieving final corticosteroid discontinuation, complete clinical response and remission in 307 JDM patients by Weibull time-to-event modelling; conditional probability of complete clinical response and remission using Bayesian network modelling; and significant predictors with multivariable Markov chain Monte-Carlo Weibull extension models...
October 17, 2020: Rheumatology
Anna Molto, Laure Gossec, Serge Poiraudeau, Pascal Claudepierre, Martin Soubrier, Françoise Fayet, Daniel Wendling, Philippe Gaudin, Emmanuelle Dernis, Sandrine Guis, Sophie Pouplin, Adeline Ruyssen-Witrand, Gerard Chales, Xavier Mariette, Catherine Beauvais, Bernard Combe, René-Marc Flipo, Pascal Richette, Isabelle Chary-Valckenaere, Alain Saraux, Jean Sibilia, Thierry Schaeverbeke, Maxime Dougados
OBJECTIVE: To evaluate the impact of a nurse-led program of self-management and self-assessment of disease activity in axial spondyloarthritis. METHODS: Prospective, randomized, controlled, open, 12-month trial (NCT02374749). Participants were consecutive axial spondyloarthritis patients (according to the rheumatologist) and nurses having participated in a 1-day training meeting. The program included self-management: educational video and specific video of graduated, home-based exercises for patients; and self-assessment: video presenting the rationale of tight monitoring of disease activity with composite scores (Ankylosing Spondylitis Disease activity Score, ASDAS/Bath Ankyslosing Spondylitis Disease Activity Index, BASDAI)...
October 16, 2020: Rheumatology
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