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Riccardo Papa, Marta Rusmini, Stefano Volpi, Roberta Caorsi, Paolo Picco, Alice Grossi, Francesco Caroli, Francesca Bovis, Valeria Musso, Laura Obici, Cinzia Castana, Angelo Ravelli, Marielle E Van Gijn, Isabella Ceccherini, Marco Gattorno
OBJECTIVES: The number of innate immune system disorders classified as systemic autoinflammatory diseases (SAID) has increased in recent years. More than 70% of patients with clinical manifestations of SAID did not receive a molecular diagnosis, thus being classed as so-called undifferentiated or undefined SAID (uSAID). The aim of the present study was to evaluate a next-generation sequencing (NGS)-based clinically oriented protocol in patients with uSAID. METHODS: We designed a NGS panel that included 41 genes clustered in seven subpanels...
July 19, 2019: Rheumatology
Sofie L M Blokland, Fréderique M van Vliet-Moret, Maarten R Hillen, Aridaman Pandit, Roel Goldschmeding, Aike A Kruize, Gerben Bouma, André van Maurik, Sven Olek, Ulrich Hoffmueller, Joel A G van Roon, Timothy R D J Radstake
OBJECTIVE: To investigate whether epigenetic cell counting represents a novel method to quantify immune cells in salivary glands of patients with different forms of Sjögren's and sicca syndrome and to capture immunopathology and potentially aid in diagnosis. METHODS: DNA from frozen salivary gland tissue sections of sicca patients was used for bisulphite conversion of demethylated DNA cytosine residues, followed by cell-specific quantitative PCR to calculate cell percentages in relation to total tissue cell numbers as quantified by housekeeping gene demethylation...
July 19, 2019: Rheumatology
Max Yates, Robert Luben, Shabina Hayat, Sarah L Mackie, Richard A Watts, Kay-Tee Khaw, Nick J Wareham, Alex J MacGregor
OBJECTIVES: PMR and GCA are associated with increased risk of vascular disease. However, it remains unclear whether this relationship is causal or reflects a common underlying propensity. The aim of this study was to identify whether known cardiovascular risk factors increase the risk of PMR and GCA. METHODS: Clinical records were examined using key word searches to identify cases of PMR and GCA, applying current classification criteria in a population-based cohort...
July 19, 2019: Rheumatology
Geraldine M McCarthy, Aisling Dunne
No abstract text is available yet for this article.
July 19, 2019: Rheumatology
Ayşe Tanatar, Şerife Gül Karadağ, Hafize Emine Sönmez, Mustafa Çakan, Nuray Aktay Ayaz
No abstract text is available yet for this article.
July 19, 2019: Rheumatology
Lukas Schlager, Michaela Loiskandl, Daniel Aletaha, Helga Radner
OBJECTIVE: To systematically review possible predictors of successful discontinuation of biologic or targeted synthetic DMARDs (b/tsDMARDs) in RA patients in remission or low disease activity. METHODS: MEDLINE database and Cochrane Library were scanned for studies that discontinued b/tsDMARDs in remission/low disease activity and searched for predictors of successful discontinuation. Additionally, EULAR and ACR meeting abstracts were hand searched. RESULTS: Thirty-four studies with a total of 5724 patients were included...
July 19, 2019: Rheumatology
Hasan Satış, Alper Şenkalfa, Hazan Karadeniz, Aslıhan Avanoğlu, Reyhan Bilici Salman, Neslihan Kayahan, Abdurrahman Tufan
No abstract text is available yet for this article.
July 19, 2019: Rheumatology
Cristina Maglio, Yuan Zhang, Markku Peltonen, Johanna Andersson-Assarsson, Per-Arne Svensson, Christian Herder, Anna Rudin, Lena Carlsson
OBJECTIVE: The aim of this study was to determine the effect of bariatric surgery on the incidence of RA in participants of the Swedish Obese Subjects (SOS) study. METHODS: The SOS is a longitudinal study aiming to assess the effect of bariatric surgery on mortality and obesity-related diseases. This report includes 2002 subjects with obesity who underwent bariatric surgery and 2034 matched controls; none of them had RA at baseline. Cases of incident RA were identified through the Swedish National Patient Register by searching for International Classification of Diseases codes...
July 18, 2019: Rheumatology
Shogo Matsuda, Takuya Kotani, Takaaki Ishida, Keisuke Fukui, Youhei Fujiki, Takayasu Suzuka, Koji Nagai, Kenichiro Hata, Takeshi Shoda, Kentaro Isoda, Yuri Ito, Shigeki Makino, Tohru Takeuchi, Shigeki Arawaka
OBJECTIVES: To elucidate the serum cytokine profile and address the pathomechanism of interstitial lung disease (ILD) complicated with PM/DM. METHODS: Forty patients with PM/DM-ILD were enrolled, and principal components analysis and cluster analysis were performed to classify patients into subgroups. Additionally, we compared cytokine profiles between the survivors and dead patients and between anti-melanoma differentiation-associated gene 5 antibody- and anti-aminoacyl tRNA synthetase antibody-positive ILD patients...
July 18, 2019: Rheumatology
Daniel Li, Kazuki Yoshida, Candance H Feldman, Cameron Speyer, Medha Barbhaiya, Hongshu Guan, Daniel H Solomon, Brendan M Everett, Karen H Costenbader
OBJECTIVE: SLE is associated with high risks of cardiovascular disease (CVD) and mortality, and has a wide spectrum of presentations. We investigated whether SLE severity at diagnosis was associated with CVD or mortality risk. METHODS: Within Medicaid (2000-10), we identified patients 18-65 years of age with incident SLE. Initial SLE severity was classified-mild, moderate, or severe-during the baseline year prior to the start of follow-up (incident index date) using a published algorithm based on SLE-related medications and diagnoses...
July 18, 2019: Rheumatology
Roy Fleischmann, Mark C Genovese, Yong Lin, Gregory St John, Désirée van der Heijde, Sheldon Wang, Juan Jose Gomez-Reino, Jose Antonio Maldonado-Cocco, Marina Stanislav, Alan J Kivitz, Gerd R Burmester
OBJECTIVE: Sarilumab is a human monoclonal antibody that blocks IL-6 from binding to membrane-bound and soluble IL-6 receptor-α. We assessed the long-term safety of sarilumab in patients from eight clinical trials and their open-label extensions. METHODS: Data were pooled from patients with rheumatoid arthritis who received at least one dose of sarilumab in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs; combination group) or as monotherapy (monotherapy group)...
July 15, 2019: Rheumatology
Jon T Einarsson, Minna Willim, Tore Saxne, Pierre Geborek, Meliha C Kapetanovic
OBJECTIVES: The aim of this study of patients with RA in Sweden was to investigate secular trends in achieving sustained remission (SR), i.e. DAS28 <2.6 on at least two consecutive occasions and lasting for at least 6 months. METHODS: All adult RA patients registered in the Swedish Rheumatology Quality register through 2012, with at least three registered visits were eligible, a total of 29 084 patients. Year of symptom onset ranged from 1955, but for parts of the analysis only patients with symptom onset between 1994 and 2009 were studied...
July 13, 2019: Rheumatology
Ronald F van Vollenhoven, Sandra V Navarra, Roger A Levy, Mathew Thomas, Amy Heath, Todd Lustine, Anthony Adamkovic, James Fettiplace, Mei-Lun Wang, Beulah Ji, David Roth
OBJECTIVE: This extension study of the Phase III, randomized, placebo-controlled Belimumab International SLE Study (BLISS)-52 and BLISS-76 studies allowed non-US patients with SLE to continue belimumab treatment, in order to evaluate its long-term safety and tolerability including organ damage accrual. METHODS: In this multicentre, long-term extension study (GlaxoSmithKline Study BEL112234) patients received i.v. belimumab every 4 weeks plus standard therapy. Adverse events (AEs) were assessed monthly and safety-associated laboratory parameters were assessed at regular intervals...
July 13, 2019: Rheumatology
Mrinalini Dey, Sizheng S Zhao, Nicola Goodson
No abstract text is available yet for this article.
July 13, 2019: Rheumatology
Holly F Hope, Kimme L Hyrich, James Anderson, James Bluett, Jamie C Sergeant, Anne Barton, Lis Cordingley, Suzanne M M Verstappen
OBJECTIVE: In order to develop interventions to optimize MTX use for the treatment of RA we evaluated the rate of, reasons for and predictors of MTX non-adherence during the first 6 months of therapy. METHODS: The Rheumatoid Arthritis Medication Study (RAMS) is a prospective multicentre cohort study of incident MTX users in the UK. Prior to MTX commencement demographic, clinical and psychological data were collected. A weekly patient-completed diary recorded MTX dose, possible side effects and adherence over 26 weeks...
July 13, 2019: Rheumatology
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Ángel I Pérez-Álvarez, Lorena Benavente, Luis Caminal-Montero, Ana Suárez
OBJECTIVE: The aim was to evaluate whether T cell subsets and the lipid profile could be linked to the cardioprotective effect of IgM anti-phosphorylcholine (PC) antibodies in SLE. METHODS: Anti-PC antibodies were quantified by ELISA in 197 patients and 99 controls and analysed in relationship to clinical features, treatments and serum lipids. Carotid atheromatosis was evaluated by ultrasonography; Th1, Th17, Treg and CD4+CD28null cells by flow cytometry; and cytokine serum levels by immunoassays, in a subgroup of 120 SLE patients and 33 controls...
July 13, 2019: Rheumatology
Javier Fernández-Torres, Nonanzit Pérez-Hernández, Gabriela Hernández-Molina, Gabriela A Martínez-Nava, Daniela Garrido-Rodríguez, Alberto López-Reyes, José M Rodríguez-Pérez
OBJECTIVE: To explore genetic polymorphisms of the Wnt/β-catenin signalling pathway in primary SS (PSS). METHODS: We included 98 patients with PSS and 165 healthy volunteers. Genomic DNA was extracted from peripheral blood samples. Through an open-array platform of low density, we genotyped 25 polymorphisms from 14 genes (WISP1, DKK1, SOST, FRZB, LRP1, LRP4, LRP5, LRP6, GSKB, ADAMTS5, GDF5, FMN2, ADIPOQ and COL11A1) involved in the Wnt/β-catenin signalling pathway...
July 13, 2019: Rheumatology
Mihaela Gamala, Johannes W G Jacobs
No abstract text is available yet for this article.
July 11, 2019: Rheumatology
Mateus F Rossato, Carin Hoffmeister, Gabriela Trevisan, Fabio Bezerra, Thiago M Cunha, Juliano Ferreira, Cassia R Silva
OBJECTIVE: The present study aimed to elucidate the mechanisms involved in MSU-induced IL-1β release in a rodent animal model of acute gout arthritis. METHODS: Painful (mechanical and thermal hypersensitivity, ongoing pain and arthritis score) and inflammatory (oedema, plasma extravasation, cell infiltration and IL-1β release) parameters were assessed several hours after intra-articular injection of MSU (100 µg/articulation) in wild-type or knockout mice for Toll-like receptor 4 (TLR4), inducible nitric oxide synthase (iNOS), transient receptor potential (TRP) V1 and the IL-1 receptor (IL-1R)...
July 11, 2019: Rheumatology
Yannick van Sleen, Annemieke M H Boots, Wayel H Abdulahad, Johan Bijzet, Maria Sandovici, Kornelis S M van der Geest, Elisabeth Brouwer
OBJECTIVES: PMR frequently co-occurs with GCA. So far, a simple biomarker for detecting concomitant arterial inflammation in PMR patients is lacking. Furthermore, biomarkers predicting disease course in PMR are awaited. We here investigated the diagnostic and prognostic value of acute-phase markers (ESR, CRP, IL-6, serum amyloid A) and angiogenesis markers (VEGF, soluble Tie2, angiopoietin-1, angiopoietin-2) in isolated PMR and PMR/GCA overlap patients. METHODS: We prospectively included 39 treatment-naïve PMR patients, of whom 10 patients also showed evidence of large vessel GCA by PET-CT...
July 10, 2019: Rheumatology
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