Rheumatology | Page 2

Nina O Nathan, Lina S Mørch, Chun S Wu, Jørn Olsen, Merete L Hetland, Jiong Li, Ane L Rom
OBJECTIVES: To investigate the influence of RA or preclinical RA on the risk of spontaneous abortion (SA) while taking age and duration of RA into consideration. METHODS: By linkage of data from Danish national registries, we established a nationwide cohort of pregnancies in Denmark from 1 January 1977 to 31 December 2014. We used multiple logistic regression to estimate; odds ratios (OR) for SA in women with RA or preclinical RA, compared with women without, and OR for SA by maternal age in women with RA or preclinical RA...
November 27, 2019: Rheumatology
Anthony M Sammel, Susan Smith, Katherine Nguyen, Rodger Laurent, Janice Brewer, Nathan Hall, Christopher B Little
OBJECTIVES: There is uncertainty if varicella zoster virus (VZV) triggers GCA. This is based on discordant reports of VZV detection in GCA temporal artery biopsies. We conducted a multimodal evaluation for VZV in the inception Giant Cell Arteritis and PET Scan (GAPS) cohort. METHODS: Consecutive patients who underwent temporal artery biopsy for suspected GCA were clinically reviewed for active and past VZV infection and followed for 6 months. Serum was tested for VZV IgM and IgG...
November 27, 2019: Rheumatology
Dimitrios Daoussis, Fevronia Kolonitsiou, Maria Militsopoulou, George Panos, Fotini Paliogianni, Elias Panagiotopoulos
No abstract text is available yet for this article.
November 27, 2019: Rheumatology
Shuzo Sato, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Makiko Furuya, Naohiko Gunji, Tatsuo Fujiwara, Tomoyuki Asano, Michio Onizawa, Hiroko Kobayashi, Hiroshi Watanabe, Hiromasa Ohira, Kiyoshi Migita
No abstract text is available yet for this article.
November 27, 2019: Rheumatology
Sho Tanaka, Hiroyuki Nakamura, Shun Tanimura, Tetsuya Horita
No abstract text is available yet for this article.
November 27, 2019: Rheumatology
Julie Seguier, Elisabeth Jouve, Mickaël Bobot, Elisabeth Whalen, Bertrand Dussol, Stéphanie Gentile, Stéphane Burtey, Philippe Halfon, Frédérique Retornaz, Damien Chaussabel, Laurent Chiche, Noémie Jourde-Chiche
OBJECTIVES: Blood transcriptomic IFN signature is a hallmark of SLE. The impaired health-related quality of life (HRQOL) observed in SLE is poorly related to disease activity. The aim of this study was to test how IFN signatures were associated with HRQOL in SLE patients. METHODS: Among consecutive patients, blood transcriptomic profiles were analysed with a modular framework comprising 3 IFN modules: M1.2, M3.4 and M5.12. Disease activity was evaluated by the SLEDAI score, and HRQOL was assessed with the SF-36 questionnaire, which includes eight domains: physical function, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health (MH) and physical component summary and mental component summary scores...
November 27, 2019: Rheumatology
Friedel Vulsteke, Jean-Baptiste Vulsteke, Tim Balthazar, Frederik H Verbrugge, Daan Dierickx, Jan Lenaerts, Patrick Verschueren, Ellen De Langhe
No abstract text is available yet for this article.
November 27, 2019: Rheumatology
Mengzhu Zhao, Yi Luo, Di Wu, Yunjiao Yang, Yang Sun, Rongrong Wang, Min Shen
OBJECTIVES: TNF receptor-associated periodic fever syndrome (TRAPS) is an autosomal dominant systemic autoinflammatory disease caused by mutations of TNF receptor superfamily member 1 A (TNFRSF1A) gene. TRAPS has hardly been reported in the Chinese population. We aimed to characterize the clinical and genetic features of Chinese adult patients with TRAPS. METHODS: Nine adult patients (≥16 years) were diagnosed during April 2015 to June 2019, at the Department of Rheumatology, Peking Union Medical College Hospital...
November 27, 2019: Rheumatology
Tatiana Nevskaya, Boyang Zheng, Carl A Baxter, Dena R Ramey, Janet E Pope, Murray Baron
OBJECTIVES: Skin improvement in diffuse cutaneous SSc (dcSSc), measured with modified Rodnan skin score (mRSS), is frequently used as a primary outcome in clinical trials, but it is uncertain whether mRSS changes reflect changes in other organ systems. This aim of this study was to explore if skin changes in early dcSSc over 1 and 2 years are associated with changes in severity of other organ involvement. METHODS: Canadian Scleroderma Research Group database patients with dcSSc, disease duration of ≤5 years, no evidence of initial end-stage organ damage and/or significant comorbidity who had 1 year (n = 154) and 2 years (n = 128) of follow-up data were included...
November 27, 2019: Rheumatology
Kathrine L Grøn, Bente Glintborg, Mette Nørgaard, Frank Mehnert, Mikkel Østergaard, Lene Dreyer, Niels S Krogh, Merete L Hetland
OBJECTIVES: Most infections in patients with RA are treated in primary care with antibiotics. A small fraction require hospitalization. Only a few studies exist regarding the overall risk of infection (i.e. prescription of antibiotics or hospitalization due to infection) in patients initiating non-TNF-inhibitor therapy. In Danish RA patients initiating abatacept, rituximab and tocilizumab treatment in routine care, the aims were to compare adjusted incidence rates (IR) of infections and to estimate relative risk of infections across the drugs during 0-12 and 0-24 months...
November 25, 2019: Rheumatology
Chetan Mukhtyar, Humphrey Hodgson
No abstract text is available yet for this article.
November 25, 2019: Rheumatology
Yukihiro Kitanaga, Emiko Imamura, Yutaka Nakahara, Hidehiko Fukahori, Yasutomo Fujii, Satoshi Kubo, Shingo Nakayamada, Yoshiya Tanaka
OBJECTIVES: Peficitinib, a novel Janus kinase (JAK) inhibitor, demonstrated promising results in treating RA in phase 3 clinical trials. This in vitro study was undertaken to characterize the pharmacological properties of peficitinib and investigate the involvement of JAK and signal transducer and activator of transcription (STAT) pathways in the pathological processes of SSc, which is also an autoimmune disease. METHODS: Phosphorylation levels of STAT molecules were assessed in peripheral blood mononuclear cells collected from patients with RA or SSc and healthy subjects, and in skin specimens obtained from 19 patients with SSc...
November 25, 2019: Rheumatology
Sophie Mavrogeni, Luna Gargani, Alessia Pepe, Lorenzo Monti, George Markousis-Mavrogenis, Maria De Santis, Daniele De Marchi, Loukia Koutsogeorgopoulou, Georgia Karabela, Efthymios Stavropoulos, Gikas Katsifis, Konstantinos Bratis, Silvia Bellando-Randone, Serena Guiducci, Cosimo Bruni, Alberto Moggi-Pignone, Theodoros Dimitroulas, Genovefa Kolovou, Vasiliki-Kalliopi Bournia, Petros P Sfikakis, Marco Matucci-Cerinic
OBJECTIVES: Cardiac rhythm disturbances constitute the most frequent cardiovascular cause of death in SSc. However, electrocardiographic findings are not a part of risk stratification in SSc. We aimed to translate 24 h Holter findings into a tangible risk prediction score using cardiovascular magnetic resonance. METHODS: The Scleroderma Arrhythmia Clinical Utility Study (SAnCtUS) was a prospective multicentre study including 150 consecutive SSc patients from eight European centres, assessed with 24 h Holter and cardiovascular magnetic resonance, including ventricular function, oedema (T2 ratio) and late gadolinium enhancement (%LGE)...
November 25, 2019: Rheumatology
Marco Fornaro, Laura Coladonato, Vincenzo Venerito, Fabio Cacciapaglia, Giuseppe Lopalco, Florenzo Iannone
No abstract text is available yet for this article.
November 25, 2019: Rheumatology
Siddharth Jain, Debajyoti Chatterjee, Sanjay Jain, Varun Dhir
No abstract text is available yet for this article.
November 22, 2019: Rheumatology
Isabelle Melki, Hervé Devilliers, Cyril Gitiaux, Vincent Bondet, Darragh Duffy, Jean-Luc Charuel, Makoto Miyara, Plamen Bokov, Ahmed Kheniche, Theresa Kwon, François Jérôme Authier, Yves Allenbach, Alexandre Belot, Christine Bodemer, Emmanuelle Bourrat, Cécile Dumaine, Nicole Fabien, Albert Faye, Marie-Louise Frémond, Alice Hadchouel, Naoki Kitabayashi, Alice Lepelley, Maria José Martin-Niclos, Sasi Mudumba, Lucile Musset, Pierre Quartier, Gillian I Rice, Luis Seabra, Florence Uettwiller, Carolina Uggenti, Sebastien Viel, Mathieu P Rodero, Yanick J Crow, Brigitte Bader-Meunier
OBJECTIVES: JDM and juvenile overlap myositis represent heterogeneous subtypes of juvenile idiopathic inflammatory myopathy (JIIM). Chronic evolution can occur in up to 60% of cases, and morbidity/mortality is substantial. We aimed to describe the clinical, biological, histological and type I IFN status in JIIM associated with anti-melanoma differentiation-associated protein 5 (anti-MDA5) autoantibodies at presentation (group 1) in comparison with other JIIM (group 2). METHODS: This was a retrospective and prospective study of patients with JIIM ascertained from three French paediatric rheumatology reference centres between 2013 and 2019...
November 22, 2019: Rheumatology
Byeongzu Ghang, Soo Min Ahn, Jinseok Kim, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
No abstract text is available yet for this article.
November 21, 2019: Rheumatology
Diederik De Cock, Joel Hirsh
No abstract text is available yet for this article.
November 20, 2019: Rheumatology
Martin Schäfer, Yvette Meißner, Jörn Kekow, Sylvia Berger, Sven Remstedt, Bernhard Manger, Joachim Listing, Anja Strangfeld, Angela Zink
OBJECTIVES: The effectiveness of TNF inhibitors in RA has been shown to be affected by obesity. No such effect has been found for abatacept and rituximab, while for tocilizumab results are ambiguous. Additionally, it remains unresolved whether sex is an effect modifier for obesity. We investigated the impact of obesity on the drug effectiveness of conventional synthetic or biologic DMARDs, taking into account potential sex-specific differences. METHODS: Data from 10 593 RA patients included in the German observational cohort study Rheumatoid Arthritis: oBservation of BIologic Therapy (RABBIT) since 2009 were analysed...
November 20, 2019: Rheumatology
Sara Muller, Rebecca Whittle, Samantha L Hider, John Belcher, Toby Helliwell, Chris Morton, Emily Hughes, Sarah A Lawton, Christian D Mallen
OBJECTIVES: To investigate potential subgroups of primary care-diagnosed patients with PMR based on self-reported pain and stiffness severity over time. METHODS: A total of 652 people with an incident PMR diagnosis were recruited from English general practices and completed a baseline postal questionnaire. They were followed up with a further six questionnaires over a 2 year period. A total of 446 people completed the 2 year follow-up. Pain and stiffness were reported on a 0-10 numerical rating scale...
November 19, 2019: Rheumatology
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