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Rheumatology | Page 2

Ruth Smith, Nikhil Kotnis, Adrian Highland, Rachel Tattersall, Stuart Carter
No abstract text is available yet for this article.
August 3, 2019: Rheumatology
Isabel Castro, Nicolás Albornoz, Sergio Aguilera, María-José Barrera, Sergio González, Matilde Núñez, Patricia Carvajal, Daniela Jara, Carolina Lagos, Claudio Molina, Ulises Urzúa, Marcela A Hermoso, María-Julieta González
OBJECTIVES: Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin expression and whether tauroursodeoxycholic acid (TUDCA) is able to counteract such an anomaly. METHODS: Labial salivary glands from 16 SS patients and 15 control subjects, as well as 3D acini or human submandibular gland cells stimulated with TNF-α or IFN-γ and co-incubated with TUDCA, were analysed...
August 3, 2019: Rheumatology
Kazuo Kawabata, Takamitsu Makino, Katsunari Makino, Ikko Kajihara, Satoshi Fukushima, Hironobu Ihn
OBJECTIVES: SSc is an autoimmune disease with chronic and persistent inflammation in its pathogenesis. To examine the expression pattern of IL-16 in SSc lesions, the serum concentration of IL-16 in SSc patients and the relationship between serum IL-16 levels and the clinical symptoms of SSc were investigated. METHODS: Using immunohistochemical analysis, we examined the quantity and localization of IL-16 in affected skin obtained from SSc patients. We also measured serum levels of IL-16 in SSc patients using an ELISA...
August 3, 2019: Rheumatology
Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba, Tsutomu Takeuchi
OBJECTIVES: To elucidate the association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis (AAV). METHODS: Peripheral blood from 36 patients with active AAV and 18 healthy controls was examined for numbers of circulating T cells, B cells, NK cells, dendritic cells, monocytes and granulocytes using flow cytometry. These immuno-phenotyping data were subjected to cluster analysis and principal components analysis to divide AAV patients into subgroups...
August 3, 2019: Rheumatology
Peter Korsten, Cornelia S Seitz, Carsten O Sahlmann, Jens Schmidt
No abstract text is available yet for this article.
August 3, 2019: Rheumatology
Beatriz Tejera Segura, Brett Sydney Bernstein, Thomas McDonnell, Chris Wincup, Vera Ripoll, Ian Giles, David Isenberg, Anisur Rahman
OBJECTIVE: Damage in patients with systemic lupus erythematosus is irreversible change in organs due to disease activity, concomitant disease or medication side-effects. It is measured using the Systemic Lupus International Collaborative Clinics Damage Index (SDI) and is associated with increased mortality. Previous reports have suggested associations between damage accrual and various ethnic, disease and treatment factors, but there is a dearth of long-term follow-up data from large multi-ethnic cohorts...
August 3, 2019: Rheumatology
Haïg Nigolian, Camillo Ribi, Delphine S Courvoisier, Sabrina Pagano, Montserrat Alvarez, Marten Trendelenburg, Uyen Huynh-Do, Nicolas Vuilleumier, Jean-Michel Dayer, Carlo Chizzolini, Pascale Roux-Lombard
OBJECTIVES: Apolipoprotein A-1 (ApoA-1) is a protein fraction of the high-density lipoproteins with anti-inflammatory and antioxidant properties that play a major role in reverse cholesterol transport. The presence of anti-ApoA-1 IgG has been reported in SLE to be variably associated with disease activity or cardiovascular events (CVEs). We assessed the clinical performance of anti-ApoA-1 IgG and of antibodies directed against its immunodominant F3L1 peptide (F3L1 IgG) in a well-characterized Swiss SLE cohort study...
August 3, 2019: Rheumatology
Alexander Oldroyd, Jamie C Sergeant, R Paul New, Neil J McHugh, Zoe Betteridge, Janine A Lamb, William E Ollier, Robert G Cooper, Hector Chinoy
No abstract text is available yet for this article.
August 3, 2019: Rheumatology
Ichiro Mizushima, Syunsuke Tsuge, Yuhei Fujisawa, Satoshi Hara, Fae Suzuki, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano
OBJECTIVES: In IgG4-related disease (IgG4-RD), relapse including recurrent organ involvement (ROI) and de novo organ involvement (DNOI) occurs frequently during the clinical course. This study aimed to clarify the differences between the risk factors underlying ROI and DNOI in IgG4-RD. METHODS: We retrospectively investigated factors related to ROI and DNOI in 86 IgG4-RD patients. For assessment of factors related to ROI and DNOI, we performed uni- and multivariate Cox regression analyses...
August 2, 2019: Rheumatology
Tobias H Cox, Sarah V Gentle, David H E Rees
No abstract text is available yet for this article.
August 2, 2019: Rheumatology
Harold Wilson-Morkeh, Ahmad Al-Abdulla, Lauren Sien, Hodan Mohamed, Taryn Youngstein
No abstract text is available yet for this article.
July 29, 2019: Rheumatology
Salvatore De Vita, Marzia De Biasio, Alen Zabotti, Giorgio Morocutti, Luca Quartuccio, Ginevra De Marchi, Alessandro Proclemer
No abstract text is available yet for this article.
July 29, 2019: Rheumatology
Minna-Maija Grönlund, Terhi Remes-Pakarinen, Liisa Kröger, Kati Markula-Patjas, Maria Backström, Anne Putto-Laurila, Kristiina Aalto, Paula Vähäsalo
OBJECTIVES: To evaluate the patterns of usage, efficacy and safety of tocilizumab in polyarticular JIA. METHODS: An observational study of 56 consecutive polyarticular JIA patients was conducted using patient charts and electronic JIA databases. Efficacy was assessed by tocilizumab survival, rates of low disease activity (LDA) and of inactive disease by 10-joint Juvenile Arthritis Disease Activity Score (JADAS-10), and of clinically inactive disease according to Wallace's preliminary criteria...
July 29, 2019: Rheumatology
Shima Yasin, Krista Solomon, Scott W Canna, Charlotte Girard-Guyonvarc'h, Cem Gabay, Eduardo Schiffrin, Andrew Sleight, Alexei A Grom, Grant S Schulert
No abstract text is available yet for this article.
July 29, 2019: Rheumatology
Boyang Zheng, Tatiana Nevskaya, Carl A Baxter, Dena R Ramey, Janet E Pope, Murray Baron
OBJECTIVE: To determine whether skin score changes are associated with changes in overall disease severity, function and quality of life in early dcSSc patients. METHODS: A total of 154 and 128 dcSSc patients from the Canadian Scleroderma Research Group database with 1 and 2 year follow-up and a disease duration ⩽5 years without end-stage organ damage and/or significant comorbidity at the initial visit were included. Skin was assessed using the modified Rodnan skin score (mRSS) and disease severity by the summed Medsger disease severity score (DSS) (without skin domain), physician and patient global assessments, function [HAQ disability index (HAQ-DI)] and quality of life [36-item Short Form Health Survey (SF-36) physical component summary (PCS)]...
July 29, 2019: Rheumatology
Sarah Drew, Emma Clark, Usama Al-Sari, Andrew Moore, Rachael Gooberman-Hill
OBJECTIVE: Older women are at particular risk of osteoporosis. Among women with osteoporosis, fractures of the vertebra (vertebral fracture) are common, hard to detect and associated with risk of further fracture. Identifying vertebral fracture in a timely manner allows instigation of preventive measures to reduce the risk of further fracture. Although detection of vertebral fracture requires spinal radiograph, many women do not receive referral. To begin development of a screening tool to identify women in need of referral we undertook a qualitative study to characterize women's experiences of vertebral fracture, using Eccleston's 'Ten Neglected Bodily Senses'...
July 23, 2019: Rheumatology
Lynn Austin, Charlotte A Sharp, Sabine N van der Veer, Matthew Machin, John Humphreys, Peter Mellor, Jill McCarthy, John Ainsworth, Caroline Sanders, William G Dixon
OBJECTIVES: To establish the acceptability and feasibility of collecting daily patient-generated health data (PGHD) using smartphones and integrating PGHD into the electronic health record, using the example of RA. METHODS: The Remote Monitoring of RA smartphone app was co-designed with patients, clinicians and researchers using qualitative semi-structured interviews and focus groups, including selection of question sets for symptoms and disease impact. PGHD were integrated into the electronic health record of one hospital and available in graphical form during consultations...
July 23, 2019: Rheumatology
Ruud H J Verstegen, Rhona McMillan, Brian M Feldman, Shinya Ito, Ronald M Laxer
OBJECTIVES: Before a clinician decides whether treatment with TNF inhibition in children with JIA has failed, one should ensure adequate systemic exposure has been achieved. Therapeutic drug monitoring might allow for improved treatment outcome with lower treatment-associated costs. However, this requires understanding of the pharmacokinetic (PK) characteristics, and the pharmacokinetic/pharmacodynamic (PK/PD) relationship for children with JIA. We performed a scoping review to summarize the available literature and identify areas for future research...
July 23, 2019: Rheumatology
Shima Yasin, Ndate Fall, Rachel A Brown, Maggie Henderlight, Scott W Canna, Charlotte Girard-Guyonvarc'h, Cem Gabay, Alexei A Grom, Grant S Schulert
OBJECTIVES: Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS and other disease biomarkers namely S100 proteins and CXCL9. METHODS: Total IL-18, CXCL9 and S100 proteins levels were determined in 40 sJIA patients, and IL-18 levels were compared between patients with regards to disease activity, history of MAS, and other biomarkers...
July 20, 2019: Rheumatology
Riccardo Papa, Marta Rusmini, Stefano Volpi, Roberta Caorsi, Paolo Picco, Alice Grossi, Francesco Caroli, Francesca Bovis, Valeria Musso, Laura Obici, Cinzia Castana, Angelo Ravelli, Marielle E Van Gijn, Isabella Ceccherini, Marco Gattorno
OBJECTIVES: The number of innate immune system disorders classified as systemic autoinflammatory diseases (SAID) has increased in recent years. More than 70% of patients with clinical manifestations of SAID did not receive a molecular diagnosis, thus being classed as so-called undifferentiated or undefined SAID (uSAID). The aim of the present study was to evaluate a next-generation sequencing (NGS)-based clinically oriented protocol in patients with uSAID. METHODS: We designed a NGS panel that included 41 genes clustered in seven subpanels...
July 19, 2019: Rheumatology
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