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Sign UpRheumatology | Page 2
• journal#21
Lewis Carpenter, Elena Nikiphorou, Patrick D W Kiely, David A Walsh, Adam Young, Sam Norton
OBJECTIVES: To examine secular trends in the progression of clinical and patient-reported outcomes in early RA. METHODS: A total of 2701 patients recruited to the Early Rheumatoid Arthritis Study or Early Rheumatoid Arthritis Network with year of diagnosis from 1986 to 2011. The 5-year progression rates for patients diagnosed at different points in time were modelled using mixed-effects regression; 1990, 2002 and 2010, were compared. Clinical markers of disease included the 28-joint count DAS and the ESR...
January 3, 2020: Rheumatology
#22
Hua-Zhi Ling, Shu-Zhen Xu, Rui-Xue Leng, Jun Wu, Hai-Feng Pan, Yin-Guang Fan, Bin Wang, Yuan-Rui Xia, Qian Huang, Zong-Wen Shuai, Dong-Qing Ye
OBJECTIVE: Clinical diagnosis of SLE is currently challenging due to its heterogeneity. Many autoantibodies are associated with SLE and are considered potential diagnostic markers, but systematic screening and validation of such autoantibodies is lacking. This study aimed to systematically discover new autoantibodies that may be good biomarkers for use in SLE diagnosis. METHODS: Sera from 15 SLE patients and 5 healthy volunteers were analysed using human proteome microarrays to identify candidate SLE-related autoantibodies...
January 3, 2020: Rheumatology
#23
Fabio Cacciapaglia, Simone Perniola, Livio Urso, Marco Fornaro, Florenzo Iannone
No abstract text is available yet for this article.
January 3, 2020: Rheumatology
#24
Aneesa Kapadia, Jafaru Abu, Suha Deen, Frances Rees
No abstract text is available yet for this article.
January 3, 2020: Rheumatology
#25
Lisa K Stamp, Peter Chapman, Christopher Frampton, Stephen B Duffull, Jill Drake, Yuqing Zhang, Tuhina Neogi
OBJECTIVES: Cherry concentrate has been suggested to reduce serum urate (SU) and gout flares. The aims of this study were to determine the magnitude of the effect of tart cherry concentrate on SU in people with gout, the most effective dose of tart cherry concentrate for lowering SU, and adverse effects. METHODS: Fifty people with gout and SU > 0.36 mmol/l were recruited. Half were on allopurinol and half were on no urate-lowering therapy. Participants were randomized to receive tart cherry juice concentrate: placebo, 7...
December 31, 2019: Rheumatology
#26
Luis F Valdés-Corona, Eric Kimura-Hayama, Victor Hugo Méndez-Cano, Carlos Antonio Hernández-Villegas, Gabriela Hernández-Molina
No abstract text is available yet for this article.
December 31, 2019: Rheumatology
#27
Marita Cross, Willy Ngueyon Sime, Lyn March, Francis Guillemin
OBJECTIVES: Lay descriptions of mild, moderate and severe disease states have been utilized in Global Burden of Disease studies in the calculation of years lived with disability, and may be a useful brief starting point for clinical care. The primary aims of this study were to estimate the proportion of an OA cohort within each severity level, and to assess the validity of lay descriptions of OA. METHODS: During 2014 to 2016, participants in the KHOALA population-based cohort completed questionnaires including pain, function, and quality of life, in addition to indicating which of the lay descriptions devised for presenting to populations in GBD2010 they felt best described their current condition...
December 31, 2019: Rheumatology
#28
Julie De Vooght, Jean-Baptiste Vulsteke, Petra De Haes, Xavier Bossuyt, Rik Lories, Ellen De Langhe
Anti-transcription intermediary factor 1 (TIF1)-γ autoantibodies are robustly linked with cancer-associated DM in adults. This review aims to give an overview of the physiological context of TIF1-γ and to determine whether there is a pathophysiological link between anti-TIF1-γ autoantibodies and the occurrence of cancer. Detection of anti-TIF1-γ autoantibodies has a high sensitivity and specificity for cancer-associated DM in adults and is therefore useful for both diagnosis and cancer risk stratification...
December 28, 2019: Rheumatology
#29
Sibylle de Germay, Haleh Bagheri, Fabien Despas, Vanessa Rousseau, François Montastruc
OBJECTIVES: We aimed to investigate whether abatacept used in patients for RA was associated with an increased risk of reporting overall cancer and specific cancers, including breast, lung, lymphoma, melanoma and non-melanoma skin cancer when compared with other biologic DMARDs (bDMARDs). METHODS: We performed an observational study within VigiBase, the World Health Organization's global database of individual case safety reports, from 2007 to 2017 to compare the cases of cancer reported in RA patients exposed to abatacept with those reported in RA patients exposed to other bDMARDs...
December 27, 2019: Rheumatology
#30
Pilar Brito-Zerón, Nihan Acar-Denizli, Wan-Fai Ng, Ildiko Fanny Horváth, Astrid Rasmussen, Raphaele Seror, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Berkan Armagan, Aike A Kruize, Seung-Ki Kwok, Marika Kvarnstrom, Sonja Praprotnik, Damien Sene, Roberto Gerli, Roser Solans, Maureen Rischmueller, Thomas Mandl, Yasunori Suzuki, David Isenberg, Valeria Valim, Piotr Wiland, Gunnel Nordmark, Guadalupe Fraile, Hendrika Bootsma, Hideki Nakamura, Roberto Giacomelli, Valerie Devauchelle-Pensec, Benedikt Hofauer, Michele Bombardieri, Virginia Fernandes Moça Trevisani, Daniel Hammenfors, Sandra G Pasoto, Soledad Retamozo, Tamer A Gheita, Fabiola Atzeni, Jacques Morel, Cristina Vollenweider, Margit Zeher, Kathy Sivils, Bei Xu, Stefano Bombardieri, Pulukool Sandhya, Salvatore De Vita, Antonina Minniti, Jorge Sánchez-Guerrero, Levent Kilic, Eefje van der Heijden, Sung-Hwan Park, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals
OBJECTIVE: To characterize the systemic phenotype of primary Sjögren's syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores. METHODS: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren's syndrome from the five continents. RESULTS: The cohort included 10 007 patients (9352 female, mean 53 years) with recorded ESSDAI scores available...
December 24, 2019: Rheumatology
#31
Himanshi Chaudhary, Roshan Matthew, Rakesh Kumar Pilania, Gummadi Anjani, Madhubala Sharma, Vignesh Pandiarajan, Shano Naseem, Bishan Radotra, Amit Rawat
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
#32
Troels Herlin, Sofie E Jørgensen, Christian Høst, Patrick S Mitchell, Maria Hønholt Christensen, Mira Laustsen, Dorthe A Larsen, Florian I Schmidt, Mette Christiansen, Trine H Mogensen
OBJECTIVES: Here we investigated a patient with inflammatory corneal intraepithelial dyskeratosis, mucosal inflammation, tooth abnormalities and, eczema to uncover the genetic and immunological basis of the disease. METHODS: On suspicion of an autoinflammatory condition, Sanger sequencing of nucleotide-binding oligomerization domain-like, leucine-rich repeat pyrin domain containing 1 (NLRP1) was performed and combined with an in vitro inflammasome reconstitution assay to measure caspase-1-mediated IL-1β cleavage, stimulation of patient peripheral blood mononuclear cells (PBMCs) and whole blood to measure IL-1β, IL-18 production and quantification of apoptosis-associated speck-like protein containing CARD (ASC) speck formation as a measure of inflammasome activation by flow cytometry...
December 24, 2019: Rheumatology
#33
Iris Navarro-Millán, Parag Goyal, Monika M Safford
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
#34
Mark Garton, Iain B McInnes, Naveed Sattar
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
#35
Philip S Helliwell
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
#36
Wenjia Sun, Ting Zhang, Huaxiang Wu, Jing Xue
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
#37
Chengsheng Ju, Rachel Wing Chuen Lai, Ka Hou Christien Li, Joshua Kai Fung Hung, Jenny C L Lai, Jeffery Ho, Yingzhi Liu, Man Fung Tsoi, Tong Liu, Bernard Man Yung Cheung, Ian Chi Kei Wong, Lai Shan Tam, Gary Tse
OBJECTIVES: The aim of this study is to determine major adverse cardiovascular events (MACE) and all-cause mortality comparing between xanthine oxidase inhibitors (XOIs) and non-XOI users, and between allopurinol and febuxostat. METHODS: This is a retrospective cohort study of gout patients prescribed anti-hyperuricemic medications between 2013 and 2017 using a territory-wide administrative database. XOI users were matched 1:1 to XOI non-users using propensity scores...
December 24, 2019: Rheumatology
#38
Bárbara Batista, Susana Escária, Filipe Morais Almeida, Vasco Fernandes, Maria Francisca Moraes-Fontes
No abstract text is available yet for this article.
December 22, 2019: Rheumatology
#39
Sizheng Steven Zhao, Daniel H Solomon, Nicola J Goodson
No abstract text is available yet for this article.
December 22, 2019: Rheumatology
#40
Maria K Kvamme, Elisabeth Lie, Till Uhlig, Tron A Moger, Tore K Kvien, Ivar S Kristiansen
No abstract text is available yet for this article.
December 22, 2019: Rheumatology
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