Isabelle Melki, Hervé Devilliers, Cyril Gitiaux, Vincent Bondet, Darragh Duffy, Jean-Luc Charuel, Makoto Miyara, Plamen Bokov, Ahmed Kheniche, Theresa Kwon, François Jérôme Authier, Yves Allenbach, Alexandre Belot, Christine Bodemer, Emmanuelle Bourrat, Cécile Dumaine, Nicole Fabien, Albert Faye, Marie-Louise Frémond, Alice Hadchouel, Naoki Kitabayashi, Alice Lepelley, Maria José Martin-Niclos, Sasi Mudumba, Lucile Musset, Pierre Quartier, Gillian I Rice, Luis Seabra, Florence Uettwiller, Carolina Uggenti, Sebastien Viel, Mathieu P Rodero, Yanick J Crow, Brigitte Bader-Meunier
OBJECTIVES: JDM and juvenile overlap myositis represent heterogeneous subtypes of juvenile idiopathic inflammatory myopathy (JIIM). Chronic evolution can occur in up to 60% of cases, and morbidity/mortality is substantial. We aimed to describe the clinical, biological, histological and type I IFN status in JIIM associated with anti-melanoma differentiation-associated protein 5 (anti-MDA5) autoantibodies at presentation (group 1) in comparison with other JIIM (group 2). METHODS: This was a retrospective and prospective study of patients with JIIM ascertained from three French paediatric rheumatology reference centres between 2013 and 2019...
November 22, 2019: Rheumatology