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JPEN. Journal of Parenteral and Enteral Nutrition

Stacy L Pelekhaty, Samuel M Galvagno, James H Lantry, Katelyn N Dolly, Daniel L Herr, Zachary N Kon, Kristopher B Deatrick, Christopher R Cornachione, Thomas M Scalea, Jay Menaker
BACKGROUND: The nutrition needs of patients requiring extracorporeal membrane oxygenation (ECMO) have not been established in the literature. The purpose of this study is to investigate if current protein recommendations are adequate to achieve nitrogen equilibrium in patients on venovenous ECMO (VV ECMO). METHODS: Patients aged ≥18 years on VV ECMO admitted November 2016 through January 2018 with a documented nitrogen balance (NB) study were included. Patients were stratified by body mass index (BMI) into obese (BMI ≥ 30 kg/m2 ) and nonobese (BMI < 30 kg/m2 ) categories for analysis...
May 15, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Leonardo Pozza Santos, Maria Cristina Gonzalez, Silvana Paiva Orlandi, Renata Moraes Bielemann, Thiago G Barbosa-Silva, Steven B Heymsfield
BACKGROUND: Low appendicular skeletal muscle mass (ASM) is associated with negative outcomes, but its assessment requires proper limb muscle evaluation. We aimed to verify how anthropometric circumferences are correlated to ASM and to develop new prediction equations based on calf circumference and other anthropometric measures, using dual-energy X-ray absorptiometry (DEXA) as the reference method. METHODS: DEXA and anthropometric information from 15,293 adults surveyed in the 1999-2006 NHANES were evaluated...
May 12, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Yannick Wouters, Hennie M J Roelofs, Mihai G Netea, René H M Te Morsche, Geert J A Wanten
BACKGROUND: Patients receiving home parenteral nutrition (HPN) have an increased risk for central line-associated bloodstream infections (CLABSIs), including candidemia. Recently, 7 single-nucleotide polymorphisms (SNPs) in TLR1, CD58, LCE4A-Clorf68, and TAGAP have been associated with the development of candidemia. Identification of host-genetic as well as clinical risk factors may help to identify patients who have an increased susceptibility to such infections. The aim of this study was to investigate the relevance of the reported SNPs in patients receiving HPN, and to explore clinical risk factors associated with candidemia...
May 10, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Mel Mariá Assunção Gomes, Jessica Moreira da Silva, Álida Rosária Silva Ferreira, Simone de Vasconcelos Generoso, Maria Isabel Toulson Davisson Correia
INTRODUCTION: The implementation of quality assessment in nutrition therapy (NT) is an important strategy, with the potential to contribute to the reduction of malnutrition and improve the cost-effectiveness of NT. Studies on this subject are scarce in the world. Our objective was to evaluate the practice of NT in hospitals located in the third-most-developed state of Brazil. METHODS: A cross-sectional study, using data collected through interviews with members of the clinical staff/interdisciplinary NT team (NTT) and audits of clinical protocols and medical records, was carried out...
May 8, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Mahmoud Abd-Elgawad, Heba Eldegla, Mohammed Khashaba, Nehad Nasef
BACKGROUND: Oropharyngeal administration of mother's colostrum in early days has an immunoprotective effect in preterm infants. OBJECTIVES: Our aim was to study the effect of oropharyngeal administration of mother's milk (OPAMM) on decreasing the incidence of nosocomial sepsis. METHODS: In a pilot prospective randomized study on preterm (<32 weeks gestation and 1500 g weight) infants, we compared OPAMM practice (applying 0.2 mL of mother's colostrum or milk prior to gavage feeding until full oral feeding is reached) with regular gavage feeding...
May 6, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Grant Hiura, Benjamin Lebwohl, David S Seres
BACKGROUND: Standardized diagnostic criteria for malnutrition were developed by the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition (AND/ASPEN) in 2012. The criteria as a whole has had little validation, and the effect of underlying condition on the impact of malnutrition has not been well studied. We measured the association between severe malnutrition and hospital length of stay (LOS), intensive care unit (ICU) LOS, and mortality among critically ill inpatients...
April 29, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Eva Budinska, Jan Gojda, Marie Heczkova, Miriam Bratova, Helena Dankova, Petr Wohl, Hana Bastova, Vera Lanska, Martin Kostovcik, Milan Dastych, Michal Senkyrik, Jarmila Krizova, Milos Mraz, Jaromir Hradecky, Jana Hajslova, Martin Lenicek, Kateřina Podzimkova, Karel Chalupsky, Radislav Sedlacek, Monika Cahova
BACKGROUND: The gut microbiome and metabolome may significantly influence clinical outcomes in patients with short bowel syndrome (SBS). The study aimed to describe specific metagenomic/metabolomics profiles of different SBS types and to identify possible therapeutic targets. METHODS: Fecal microbiome (FM), volatile organic compounds (VOCs), and bile acid (BA) spectrum were analyzed in parenteral nutrition (PN)-dependent SBS I, SBS II, and PN-independent (non-PN) SBS patients...
April 29, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Lisa Martin, Ioannis Gioulbasanis, Pierre Senesse, Vickie E Baracos
BACKGROUND: Overweight/obese patients' large fat mass can mask the loss of skeletal muscle, which is associated with mortality in the oncology setting. We investigated the prevalence of computed tomography (CT)-defined sarcopenia and myosteatosis across different levels of nutrition risk assessed by the Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF). We also evaluated whether the PG-SGA SF, sarcopenia, and myosteatosis were prognostic of overall survival. METHODS: This was a prospective, observational study...
April 22, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Valéria Girard Fabiano Alves, Eduardo Eiras Moreira da Rocha, Maria Cristina Gonzalez, Rosana Barcellos Vieira da Fonseca, Mônica Hissa do Nascimento Silva
BACKGROUND: The adequate provision of energy for obese patients by estimation without indirect calorimetry (IC) is challenging. The goal was to establish values of kilocalories per kilogram (kcal/kg) for patients in different ranges of body mass index (BMI [kg/m2 ]) comparable to resting energy expenditure (REE [kcal/kg/d]) measurements by IC. METHODS: In 63 overweight (OW) hospitalized patients with BMIs (25.0-29.9) or obesity (OB; ≥30), the REE was measured in fasting and fed states...
April 22, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Maelle Martin, Jean Reignier, Aurélie Le Thuaut, Jean Claude Lacherade, Laurent Martin-Lefèvre, Maud Fiancette, Isabelle Vinatier, Christine Lebert, Konstantinos Bachoumas, Aihem Yehia, Matthieu Henry Lagarrigue, Gwenhael Colin, Jean Baptiste Lascarrou
BACKGROUND: Whether providing nutrition support is beneficial or deleterious during targeted temperature management (TTM) after cardiac arrest is unclear. We therefore performed a retrospective observational study to determine whether early nutrition was beneficial or deleterious during TTM. METHODS: We retrospectively studied patients admitted to our intensive care unit (ICU) between 2008 and 2014 after successfully resuscitated cardiac arrest. We compared the group given nutrition within 48 hours after ICU admission (E+ group) to the group given nutrition later on or not at all (E- group)...
April 22, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Ronald L Koretz
No abstract text is available yet for this article.
April 22, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Kevin M Baskin, Leonard A Mermel, Theodore F Saad, Janna M Journeycake, Carrie M Schaefer, Biren P Modi, John I Vrazas, Beth Gore, Barbie B Drews, Darcy Doellman, Samuel A Kocoshis, Kareem M Abu-Elmagd, Richard B Towbin
Children with chronic illness often require prolonged or repeated venous access. They remain at high risk for venous catheter-related complications (high-risk patients), which largely derive from elective decisions during catheter insertion and continuing care. These complications result in progressive loss of the venous capital (patent and compliant venous pathways) necessary for delivery of life-preserving therapies. A nonstandardized, episodic, isolated approach to venous care in these high-need, high-cost patients is too often the norm, imposing a disproportionate burden on affected persons and escalating costs...
April 21, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Kristina Chen, Fan Mu, Jipan Xie, Sneha S Kelkar, Clément Olivier, James Signorovitch, Palle B Jeppesen
BACKGROUND: Teduglutide reduces or eliminates parenteral support (PS) dependency in patients with short bowel syndrome (SBS). Recent post hoc analyses demonstrated that effects are correlated with baseline PS volume. We assessed the SBS-related quality-of-life (QoL) impact of teduglutide, particularly whether improvements are greater among subgroups achieving more PS volume reduction. METHODS: Using phase 3 trial data of teduglutide in patients with SBS (NCT00798967), change in Short Bowel Syndrome-Quality of Life (SBS-QoL) scores from baseline were compared between teduglutide vs placebo in the overall population and subgroups classified by baseline PS volume requirement, disease etiology, and bowel anatomy...
April 21, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Michael Skinner, L H Lumey, Tom P Fleming, Carmen Sapienza, Cathrine Hoyo, Lucia Aronica, Jeff Thompson, Peter F Nichol
The goal of the 2018 American Society for Parenteral and Enteral Nutrition (ASPEN) Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally. A growing compendium of research indicates that the incidence and severity of common and costly human diseases may be influenced by dietary exposures and deficiencies that modify the epigenome...
April 17, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Ray Segebrecht, Michael Moncure, Ashley Bennett, Douglas Geehan, Charles W Van Way, Lamont Weide
Diabetic ketoacidosis is defined as hyperglycemia >250 mg/dL with metabolic acidosis of arterial pH <7.3, serum bicarbonate <18 mEq/L with positive urine and serum ketones and an anion gap >10. Euglycemic ketoacidosis has been reported in patients with type 2 diabetes and in patients with type 1 diabetes. However, as a surgical complication, euglycemic ketoacidosis has not been reported. We report 2 cases from 2 teaching tertiary care centers of patients with type 2 diabetes who developed high-gap ketoacidosis in an intensive care unit while recovering from emergent abdominal surgery...
April 17, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Anne Kathrine Nissen Pedersen, Charlotte Rud, Trine Levring Wilkens, Mette Borre, Jens Rikardt Andersen, Jens Frederik Dahlerup, Christian Lodberg Hvas
BACKGROUND: Sodium deficiency in patients with an ileostomy is associated with chronic dehydration and may be difficult to detect. We aimed to investigate if the sodium concentration in a single spot urine sample may be used as a proxy for 24-hour urine sodium excretion. METHODS: In a prospective observational study with 8 patients with an ileostomy and 8 volunteers with intact intestines, we investigated the correlations and agreements between spot urine sodium concentrations and 24-hour urine sodium excretions...
April 15, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Wei-Kuo Chang, Hsin-Hung Huang, Hsuan-Hwai Lin, Chen-Liang Tsai
BACKGROUND: Aspiration pneumonia is the most common cause of death in patients who undergo percutaneous endoscopic gastrostomy (PEG). This study aims to evaluate the severity of oropharyngeal dysphagia and predict the risk of pneumonia in such patients, using upper gastrointestinal endoscopy. METHODS: Endoscope examined the pharyngolaryngeal region in patients who underwent PEG. The severity of oropharyngeal dysphagia was evaluated according to the amount and location of pooling of secretions in the pharyngolaryngeal region...
April 14, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Angelique Huijbers, Lieke M Koggel, Carolien Bronkhorst, Joanne Verheij, Geert J A Wanten
Chronic intestinal failure (CIF) patients are at risk for developing intestinal failure-associated liver disease (IFALD), which can progress to end-stage liver disease. Liver biopsy is the current reference standard to diagnose and monitor IFALD. However, due to its associated complications, biopsy is an unattractive tool in this respect. Our aim was to assess the evidence regarding non-invasive assessment of IFALD in the adult population and provide ideas to take this field further. We searched the PubMed, EMBASE and Web of Science databases in accordance with the PRISMA guideline...
April 1, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Mihai Puia-Dumitrescu, Daniel K Benjamin, P Brian Smith, Rachel G Greenberg, Nada Abuzaid, Winsome Andrews, Kris Chellani, Anjali Gupta, Douglas Price, Ciara Williams, William F Malcolm, Reese H Clark, Kanecia O Zimmerman
BACKGROUND: Gastrostomy tube (G-tube) placement is a long-term alternative to oral or nasogastric feeding for premature infants who cannot safely feed orally or need supplemental nutrition for adequate growth. METHODS: We compared daily weight changes for G-tube infants 14 and 30 days preplacement and postplacement, excluding the first 7 days post-G-tube insertion. Infants <37 weeks of gestation without major congenital anomalies and discharged from 327 United States neonatal intensive care units (2004-2013) were included...
March 25, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Leah Gramlich, Carol Ireton-Jones, John M Miles, Maya Morrison, Alessandro Pontes-Arruda
Linoleic acid (LA) and α-linolenic acid (ALA) must be supplied to the human body and are therefore considered essential fatty acids. This narrative review discusses the signs, symptoms, diagnosis, prevention, and treatment of essential fatty acid deficiency (EFAD). EFAD may occur in patients with conditions that severely limit the intake, digestion, absorption, and/or metabolism of fat. EFAD may be prevented in patients requiring parenteral nutrition by inclusion of an intravenous lipid emulsion (ILE) as a source of LA and ALA...
March 25, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
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