journal
https://read.qxmd.com/read/32970476/endotheliopathy-is-induced-by-plasma-from-critically-ill-patients-and-associated-with-organ-failure-in-severe-covid-19
#1
LETTER
Antoine Rauch, Annabelle Dupont, Julien Goutay, Morgan Caplan, Senna Staessens, Mouhamed Moussa, Emmanuelle Jeanpierre, Delphine Corseaux, Guillaume Lefevre, Fanny Lassalle, Karine Faure, Marc Lambert, Alain Duhamel, Julien Labreuche, Delphine Garrigue, Simon F De Meyer, Bart Staels, Eric Van Belle, Flavien Vincent, Eric Kipnis, Peter Lenting, Julien Poissy, Sophie Susen
No abstract text is available yet for this article.
September 24, 2020: Circulation
https://read.qxmd.com/read/32969716/two-tales-one-story-emperor-reduced-and-dapa-hf
#2
Subodh Verma, Darren K McGuire, Mikhail N Kosiborod
No abstract text is available yet for this article.
September 24, 2020: Circulation
https://read.qxmd.com/read/32969710/an-urgent-need-for-studies-of-the-late-effects-of-sars-cov-2-on-the-cardiovascular-system
#3
Joseph J Maleszewski, Phillip M Young, Michael J Ackerman, Marc K Halushka
No abstract text is available yet for this article.
September 24, 2020: Circulation
https://read.qxmd.com/read/32967446/p-cosca-pediatric-core-outcome-set-for-cardiac-arrest-in-children-an-advisory-statement-from-the-international-liaison-committee-on-resuscitation
#4
Alexis A Topjian, Barnaby R Scholefield, Neethi P Pinto, Ericka L Fink, Corinne M P Buysse, Kirstie Haywood, Ian Maconochie, Vinay M Nadkarni, Allan de Caen, Raffo Escalante-Kanashiro, Kee-Chong Ng, Gabrielle Nuthall, Amelia G Reis, Patrick Van de Voorde, Stacy J Suskauer, Stephen M Schexnayder, Mary Fran Hazinski, Beth S Slomine
Studies of pediatric cardiac arrest use inconsistent outcomes, including return of spontaneous circulation and short-term survival, and basic assessments of functional and neurological status. In 2018, the International Liaison Committee on Resuscitation sponsored the COSCA initiative (Core Outcome Set After Cardiac Arrest) to improve consistency in reported outcomes of clinical trials of adult cardiac arrest survivors and supported this P-COSCA initiative (Pediatric COSCA). The P-COSCA Steering Committee generated a list of potential survival, life impact, and economic impact outcomes and assessment time points that were prioritized by a multidisciplinary group of healthcare providers, researchers, and parents/caregivers of children who survived cardiac arrest...
September 24, 2020: Circulation
https://read.qxmd.com/read/32966752/cardiometabolic-traits-sepsis-and-severe-covid-19-a-mendelian-randomization-investigation
#5
LETTER
Mark J Ponsford, Apostolos Gkatzionis, Venexia M Walker, Andrew J Grant, Robyn E Wootton, Luke S P Moore, Segun Fatumo, Amy M Mason, Verena Zuber, Cristen Willer, Humaira Rasheed, Ben Brumpton, Kristian Hveem, Jan Kristian Damås, Neil Davies, Bjørn Olav Åsvold, Erik Solligård, Simon Jones, Stephen Burgess, Tormod Rogne, Dipender Gill
No abstract text is available yet for this article.
September 23, 2020: Circulation
https://read.qxmd.com/read/32965135/james-t-willerson-md-in-memoriam
#6
Joseph A Hill, Joseph Loscalzo
No abstract text is available yet for this article.
September 23, 2020: Circulation
https://read.qxmd.com/read/32964749/automated-recognition-of-regional-wall-motion-abnormalities-through-deep-neural-network-interpretation-of-transthoracic-echocardiography
#7
Mu-Shiang Huang, Chi-Shiang Wang, Jung-Hsien Chiang, Ping-Yen Liu, Wei-Chuan Tsai
Background: Automated interpretation of echocardiography by deep neural networks could support clinical reporting and improve efficiency. Whilst prior studies have evaluated spatial relationships using still frame images, our aim was to train and test a deep neural network for video analysis by combining spatial and temporal information, to automate the recognition of left ventricular regional wall motion abnormalities. Methods: We collected a series of transthoracic echocardiography examinations performed between July 2017 and April 2018 in two tertiary care hospitals...
September 23, 2020: Circulation
https://read.qxmd.com/read/32962412/single-cell-genomics-reveals-a-novel-cell-state-during-smooth-muscle-cell-phenotypic-switching-and-potential-therapeutic-targets-for-atherosclerosis-in-mouse-and-human
#8
Huize Pan, Chenyi Xue, Benjamin J Auerbach, Jiaxin Fan, Alexander C Bashore, Jian Cui, Dina Y Yang, Sarah B Trignano, Wen Liu, Jianting Shi, Chinyere O Ihuegbu, Erin C Bush, Jeremy Worley, Lukas Vlahos, Pasquale Laise, Robert A Solomon, Edward S Connolly, Andrea Califano, Peter A Sims, Hanrui Zhang, Mingyao Li, Muredach P Reilly
Background: Smooth muscle cells (SMC) play significant roles in atherosclerosis via phenotypic switching, a pathological process in which SMC dedifferentiation, migration and transdifferentiation into other cell types. Yet, how SMC contribute to pathophysiology of atherosclerosis remains elusive. Methods: To reveal the trajectories of SMC transdifferentiation during atherosclerosis and to identify molecular targets for disease therapy, we combined SMC fate mapping and single-cell RNA sequencing of both mouse and human atherosclerotic plaques...
September 23, 2020: Circulation
https://read.qxmd.com/read/32954796/ten-year-differences-in-women-s-awareness-related-to-coronary-heart-disease-results-of-the-2019-american-heart-association-national-survey-a-special-report-from-the-american-heart-association
#9
Mary Cushman, Christina M Shay, Virginia J Howard, Monik C Jiménez, Jennifer Lewey, Jean C McSweeney, L Kristin Newby, Ram Poudel, Harmony R Reynolds, Kathryn M Rexrode, Mario Sims, Lori J Mosca
BACKGROUND: High awareness that cardiovascular disease is the leading cause of death (LCOD) among women is critical to prevention. This study evaluated longitudinal trends in this awareness among women. METHODS AND RESULTS: Online surveys of US women (≥25 years of age) were conducted in January 2009 and January 2019. Data were weighted to the US population distribution of sociodemographic characteristics. Multivariable logistic regression was used to evaluate knowledge of the LCOD...
September 21, 2020: Circulation
https://read.qxmd.com/read/32951451/trends-in-recurrent-coronary-heart-disease-following-myocardial-infarction-among-us-women-and-men-between-2008-and-2017
#10
Sanne A E Peters, Lisandro D Colantonio, Yuling Dai, Hong Zhao, Vera A Bittner, Michael E Farkouh, Paul Dluzniewski, Bharat Poudel, Paul Muntner, Mark Woodward
Background: Rates for recurrent coronary heart disease (CHD) events have declined in the US. However, few studies have assessed whether this decline has been similar among women and men. Methods: Data were used from 770,408 US women and 700,477 US men <65 years of age with commercial health insurance through MarketScan and ≥66 years of age with government health insurance through Medicare who had a myocardial infarction (MI) hospitalization between 2008 and 2017. Women and men were followed for recurrent MI, recurrent CHD events (i...
September 21, 2020: Circulation
https://read.qxmd.com/read/32948096/the-covid-19-pandemic-a-massive-threat-for-those-living-with-cardiovascular-disease-among-the-poorest-billion
#11
Sheila L Klassen, Gene F Kwan, Gene Bukhman
No abstract text is available yet for this article.
September 18, 2020: Circulation
https://read.qxmd.com/read/32946302/neutrophils-and-contact-activation-of-coagulation-as-potential-drivers-of-covid-19
#12
LETTER
Matthias H Busch, Sjoerd A M E G Timmermans, Magdolna Nagy, Mayken Visser, Joram Huckriede, Joop P Aendekerk, Femke de Vries, Judith Potjewijd, Borefore Jallah, Renee Ysermans, Astrid M L Oude Lashof, Paul H Breedveld, Marcel C G van de Poll, Iwan C C van der Horst, Bas C T van Bussel, Ruud O M F I H Theunissen, Henri M H Spronk, Jan G M C Damoiseaux, Hugo Ten Cate, Gerry A F Nicolaes, Chris P Reutelingsperger, Pieter van Paassen
No abstract text is available yet for this article.
September 18, 2020: Circulation
https://read.qxmd.com/read/32933333/signalosome-regulated-srf-phosphorylation-determining-myocyte-growth-in-width-versus-length-as-a-therapeutic-target-for-heart-failure
#13
Jinliang Li, Yuliang Tan, Catherine L Passariello, Eliana C Martinez, Michael D Kritzer, Xueyi Li, Xiaofeng Li, Yang Li, Qian Yu, Kenneth Ohgi, Hrishikesh Thakur, John W MacArthur, Jan R Ivey, Y Joseph Woo, Craig A Emter, Kimberly Dodge-Kafka, Michael G Rosenfeld, Michael S Kapiloff
Background: Concentric and eccentric cardiac hypertrophy are associated with pressure and volume overload, respectively, in cardiovascular disease both conferring an increased risk of heart failure. These contrasting forms of hypertrophy are characterized by asymmetric growth of the cardiac myocyte in mainly width or length, respectively. The molecular mechanisms determining myocyte preferential growth in width versus length remain poorly understood. Identification of the mechanisms governing asymmetric myocyte growth could provide new therapeutic targets for the prevention or treatment of heart failure...
September 16, 2020: Circulation
https://read.qxmd.com/read/32929996/drug-induced-arrhythmias-a-scientific-statement-from-the-american-heart-association
#14
James E Tisdale, Mina K Chung, Kristen B Campbell, Muhammad Hammadah, Jose A Joglar, Jacinthe Leclerc, Bharath Rajagopalan
Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological drugs, anticancer agents, and many others), can prolong the QT interval and provoke torsades de pointes. Perhaps less familiar to clinicians is the fact that drugs can also trigger other arrhythmias, including bradyarrhythmias, atrial fibrillation/atrial flutter, atrial tachycardia, atrioventricular nodal reentrant tachycardia, monomorphic ventricular tachycardia, and Brugada syndrome...
September 15, 2020: Circulation
https://read.qxmd.com/read/32929989/single-cell-rna-seq-unveils-unique-transcriptomic-signatures-of-organ-specific-endothelial-cells
#15
David T Paik, Lei Tian, Ian M Williams, Siyeon Rhee, Hao Zhang, Chun Liu, Ridhima Mishra, Sean M Wu, Kristy Red-Horse, Joseph C Wu
Background: Endothelial cells (ECs) display considerable functional heterogeneity depending on the vessel and tissue in which they are located. While these functional differences are presumably imprinted in the transcriptome, the pathways and networks which sustain EC heterogeneity have not been fully delineated. Methods: To investigate the transcriptomic basis of EC specificity, we analyzed single-cell RNA-sequencing (scRNA-seq) data from tissue-specific mouse ECs generated by the Tabula Muris consortium. We employed a number of bioinformatics tools to uncover markers and sources of EC heterogeneity from scRNA-seq data...
September 15, 2020: Circulation
https://read.qxmd.com/read/32929985/complex-arrhythmia-syndrome-in-a-knock-in-mouse-model-carrier-of-the-n98s-calm1-mutation
#16
Wen-Chin Tsai, Shuai Guo, Michael A Olaopa, Loren J Field, Jin Yang, Changyu Shen, Ching-Pin Chang, Peng-Sheng Chen, Michael Rubart
Background: Calmodulin mutations are associated with arrhythmia syndromes in humans. Exome sequencing previously identified a de novo mutation in CALM1 resulting in a p.N98S substitution in a patient with sinus bradycardia and stress-induced bidirectional ventricular ectopy. The objectives of the present study were to determine if mice carrying the N98S mutation knocked into Calm1 replicate the human arrhythmia phenotype and to examine arrhythmia mechanisms. Methods: Mouse lines heterozygous for the Calm1N98S allele (Calm1N98S/+ ) were generated using CRISPR/Cas9 technology...
September 15, 2020: Circulation
https://read.qxmd.com/read/32927962/metabolic-architecture-of-acute-exercise-response-in-middle-aged-adults-in-the-community
#17
Matthew Nayor, Ravi V Shah, Patricia E Miller, Jasmine B Blodgett, Melissa Tanguay, Alexander R Pico, Venkatesh L Murthy, Rajeev Malhotra, Nicholas E Houstis, Amy Deik, Kerry A Pierce, Kevin Bullock, Lucas Dailey, Raghava S Velagaleti, Stephanie A Moore, Jennifer E Ho, Aaron L Baggish, Clary B Clish, Martin G Larson, Ramachandran S Vasan, Gregory D Lewis
Background: While regular exercise exposure is associated with lower risk of cardiovascular disease (CVD) and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans. Methods: Cardiopulmonary exercise testing (CPET) and metabolite profiling was performed on Framingham Heart Study (FHS) participants (age 53±8 years, 63% women) with blood drawn at rest (n=471) and at peak exercise (n=411)...
September 15, 2020: Circulation
https://read.qxmd.com/read/32910681/established-cardiovascular-biomarkers-provide-limited-prognostic-information-in-unselected-patients-hospitalized-with-covid-19
#18
LETTER
Torbjørn Omland, Christian Prebensen, Ragnhild Røysland, Signe Søvik, Vibecke Sørensen, Helge Røsjø, My Svensson, Jan Erik Berdal, Peder L Myhre
No abstract text is available yet for this article.
September 10, 2020: Circulation
https://read.qxmd.com/read/32900241/cd4-t-cell-endogenous-cystathionine-%C3%AE-lyase-hydrogen-sulfide-attenuates-hypertension-by-sulfhydrating-liver-kinase-b1-to-promote-t-regulatory-cell-differentiation-and-proliferation
#19
Changting Cui, Jinghui Fan, Qiang Zeng, Junyan Cai, Yongzeng Chen, Zhenzhen Chen, Wenjie Wang, Shuang Yue Li, Qinghua Cui, Jichun Yang, Chaoshu Tang, Guoheng Xu, Jun Cai, Bin Geng
Background: Hydrogen sulfide (H2 S) has anti-hypertension and anti-inflammatory effects, and its endogenous-generation key enzyme cystathionine γ lyase (CSE) is expressed in CD4+ T cells. However, the role of CD4+ T-cell endogenous CSE/H2 S in the development of hypertension is unclear. Methods: Peripheral blood lymphocytes were isolated from hypertensive patients or spontaneously hypertensive rats (SHRs), then H2 S production and expression of its generation enzymes, cystathionine β synthase (CBS) and CSE, were measured to determine the major H2 S generation system changes in hypertension...
September 9, 2020: Circulation
https://read.qxmd.com/read/32894978/immune-checkpoint-inhibitor-therapy-induces-inflammatory-activity-in-large-arteries
#20
LETTER
Raffaella Calabretta, Christoph Hoeller, Verena Pichler, Markus Mitterhauser, Georgios Karanikas, Alexander Haug, Xiang Li, Marcus Hacker
No abstract text is available yet for this article.
September 8, 2020: Circulation
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