journal
https://read.qxmd.com/read/36924225/evaluation-and-management-of-pulmonary-hypertension-in-noncardiac-surgery-a-scientific-statement-from-the-american-heart-association
#1
REVIEW
Sudarshan Rajagopal, Kurt Ruetzler, Kamrouz Ghadimi, Evelyn M Horn, Marta Kelava, Kristina T Kudelko, Ingrid Moreno-Duarte, Ioana Preston, Leonie L Rose Bovino, Nathaniel R Smilowitz, Anjali Vaidya
Pulmonary hypertension, defined as an elevation in blood pressure in the pulmonary arteries, is associated with an increased risk of death. The prevalence of pulmonary hypertension is increasing, with an aging population, a rising prevalence of heart and lung disease, and improved pulmonary hypertension survival with targeted therapies. Patients with pulmonary hypertension frequently require noncardiac surgery, although pulmonary hypertension is associated with excess perioperative morbidity and death. This scientific statement provides guidance on the evaluation and management of pulmonary hypertension in patients undergoing noncardiac surgery...
March 16, 2023: Circulation
https://read.qxmd.com/read/36919608/plasma-progerin-in-patients-with-hutchinson-gilford-progeria-syndrome-immunoassay-development-and-clinical-evaluation
#2
JOURNAL ARTICLE
Leslie B Gordon, Wendy Norris, Sarah Hamren, Robert Goodson, Jessica LeClair, Joseph Massaro, Asya Lyass, Ralph B D'Agostino, Kelsey Tuminelli, Mark W Kieran, Monica E Kleinman
BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare, fatal, premature aging disease caused by a toxic protein called progerin. Circulating progerin has not been previously detected, precluding research using readily available biological samples. This study aimed to develop a plasma progerin assay to evaluate progerin's quantity, response to progerin-targeted therapy, and relationship to patient survival. METHODS: Biological samples were collected by The Progeria Research Foundation Cell and Tissue Bank from a non-HGPS cohort cross-sectionally and a HGPS cohort longitudinally...
March 15, 2023: Circulation
https://read.qxmd.com/read/36912163/expression-of-concern-c-cbl-inhibition-improves-cardiac-function-and-survival-in-response-to-myocardial-ischemia
#3
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2023: Circulation
https://read.qxmd.com/read/36912134/atrial-fibrillation-occurring-during-acute-hospitalization-a-scientific-statement-from-the-american-heart-association
#4
REVIEW
Janice Y Chyou, Ebrahim Barkoudah, Jonathan W Dukes, Larry B Goldstein, Jose A Joglar, Anson M Lee, Steven A Lubitz, Keith A Marill, Kevin B Sneed, Megan M Streur, Graham C Wong, Rakesh Gopinathannair
Acute atrial fibrillation is defined as atrial fibrillation detected in the setting of acute care or acute illness; atrial fibrillation may be detected or managed for the first time during acute hospitalization for another condition. Atrial fibrillation after cardiothoracic surgery is a distinct type of acute atrial fibrillation. Acute atrial fibrillation is associated with high risk of long-term atrial fibrillation recurrence, warranting clinical attention during acute hospitalization and over long-term follow-up...
March 13, 2023: Circulation
https://read.qxmd.com/read/36883479/nitrative-modification-of-caveolin-3-a-novel-mechanism-of-cardiac-insulin-resistance-and-a-potential-therapeutic-target-against-ischemic-heart-failure-in-prediabetic-animals
#5
JOURNAL ARTICLE
Zhijun Meng, Zhen Zhang, Jianli Zhao, Caihong Liu, Peng Yao, Ling Zhang, Dina Xie, Wayne Bond Lau, Jumpei Tsukuda, Theodore A Christopher, Bernard Lopez, Di Zhu, Demin Liu, John Ry Zhang, Erhe Gao, Harry Ischiropoulos, Walter Koch, Xinliang Ma, Yajing Wang
BACKGROUND: Myocardial insulin resistance is a hallmark of diabetic cardiac injury. However, the underlying molecular mechanisms remain unclear. Recent studies demonstrate that the diabetic heart is resistant to other cardioprotective interventions, including adiponectin and preconditioning. The "universal" resistance to multiple therapeutic interventions suggests impairment of the requisite molecule(s) involved in broad prosurvival signaling cascades. Cav (Caveolin) is a scaffolding protein coordinating transmembrane signaling transduction...
March 8, 2023: Circulation
https://read.qxmd.com/read/36883458/mechanical-thrombectomy-global-access-for-stroke-mt-glass-a-mission-thrombectomy-mt-2020-plus-study
#6
JOURNAL ARTICLE
Kaiz S Asif, Fadar O Otite, Shashvat M Desai, Nabeel Herial, Violiza Inoa, Fawaz Al-Mufti, Ashutosh P Jadhav, Adam A Dmytriw, Alicia Castonguay, Priyank Khandelwal, Jennifer Potter-Vig, Viktor Szeder, Tanzila Kulman, Victor Urrutia, Hesham Masoud, Gabor Toth, Kaustubh Limaye, Sushanth Aroor, Waleed Brinjikji, Ansaar Rai, Jeyaraj Pandian, Mehari Gebreyohanns, Thomas Leung, Ossama Mansour, Andrew M Demchuk, Vikram Huded, Sheila Martins, Osama Zaidat, Xiaochuan Huo, Bruce Campbell, P N Sylaja, Zhongrong Miao, Jeffrey Saver, Santiago Ortega-Gutierrez, Dileep R Yavagal
BACKGROUND: Despite the well-established potent benefit of mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke, access to MT has not been studied globally. We conducted a worldwide survey of countries on 6 continents to define MT access (MTA), the disparities in MTA, and its determinants on a global scale. METHODS: Our survey was conducted in 75 countries through the Mission Thrombectomy 2020+ global network between November 22, 2020, and February 28, 2021...
March 8, 2023: Circulation
https://read.qxmd.com/read/36883452/pregnancy-complications-and-long-term-mortality-in-a-diverse-cohort
#7
JOURNAL ARTICLE
Stefanie N Hinkle, Enrique F Schisterman, Danping Liu, Anna Z Pollack, Edwina H Yeung, Sunni L Mumford, Katherine L Grantz, Yan Qiao, Neil J Perkins, James L Mills, Pauline Mendola, Cuilin Zhang
BACKGROUND: Pregnancy complications are associated with increased risk of development of cardiometabolic diseases and earlier mortality. However, much of the previous research has been limited to White pregnant women. We aimed to investigate pregnancy complications in association with total and cause-specific mortality in a racially diverse cohort and evaluate whether associations differ between Black and White pregnant women. METHODS: The Collaborative Perinatal Project was a prospective cohort study of 48 197 pregnant women at 12 US clinical centers (1959-1966)...
March 8, 2023: Circulation
https://read.qxmd.com/read/36877670/prevalence-of-diabetes-and-cardiovascular-risk-in-the-middle-east-and-africa-primary-results-of-the-pact-mea-study
#8
LETTER
Subodh Verma, Naji Alamuddin, Fatheya Alawadi, Hessa Alkandari, Wael Al Mahmeed, Samir H Assaad-Khalil, Jihad Haddad, Lise Lotte N Husemoen, Landman Lombard, Rayaz A Malik, Emel Mashaki Ceyhan, Hani Sabbour, Gamze Tombak, Gourav Yadav, Sam Salek
No abstract text is available yet for this article.
March 6, 2023: Circulation
https://read.qxmd.com/read/36877118/pulsed-field-ablation-for-the-treatment-of-atrial-fibrillation-pulsed-af-pivotal-trial
#9
JOURNAL ARTICLE
Atul Verma, David E Haines, Lucas V Boersma, Nitesh Sood, Andrea Natale, Francis E Marchlinski, Hugh Calkins, Prashanthan Sanders, Douglas L Packer, Karl-Heinz Kuck, Gerhard Hindricks, Birce Onal, Jeffrey Cerkvenik, Hiroshi Tada, David B DeLurgio
BACKGROUND: Pulsed field ablation uses electrical pulses to cause nonthermal irreversible electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness comparable to traditional catheter ablation while preventing thermally mediated complications. METHODS: The PULSED AF pivotal study (Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF) was a prospective, global, multicenter, nonrandomized, paired single-arm study in which patients with paroxysmal (n=150) or persistent (n=150) symptomatic atrial fibrillation (AF) refractory to class I or III antiarrhythmic drugs were treated with pulsed field ablation...
March 6, 2023: Circulation
https://read.qxmd.com/read/36876489/disruption-of-phosphodiesterase-3a-binding-to-serca2-increases-serca2-activity-and-reduces-mortality-in-mice-with-chronic-heart-failure
#10
JOURNAL ARTICLE
Jonas Skogestad, Ingrid Albert, Karina Hougen, Gustav B Lothe, Marianne Lunde, Olav Søvik Eken, Ioanni Veras, Ngoc Trang Thi-Huynh, Mira Børstad, Serena Marshall, Xin Shen, William E Louch, Emma Louise Robinson, Joseph C Cleveland, Amrut V Ambardekar, Jessica A Schwisow, Eric Jonas, Ana Isabel Costa Calejo, Jens Preben Morth, Kjetil Taskén, Arne Olav Melleby, Per Kristian Lunde, Ivar Sjaastad, Cathrine Rein Carlson, Jan Magnus Aronsen
BACKGROUND: Increasing SERCA2 (sarco[endo]-plasmic reticulum Ca2+ ATPase 2) activity is suggested to be beneficial in chronic heart failure, but no selective SERCA2-activating drugs are available. PDE3A (phosphodiesterase 3A) is proposed to be present in the SERCA2 interactome and limit SERCA2 activity. Disruption of PDE3A from SERCA2 might thus be a strategy to develop SERCA2 activators. METHODS: Confocal microscopy, 2-color direct stochastic optical reconstruction microscopy, proximity ligation assays, immunoprecipitations, peptide arrays, and surface plasmon resonance were used to investigate colocalization between SERCA2 and PDE3A in cardiomyocytes, map the SERCA2/PDE3A interaction sites, and optimize disruptor peptides that release PDE3A from SERCA2...
March 6, 2023: Circulation
https://read.qxmd.com/read/36876483/patient-characteristics-outcomes-and-effects-of-dapagliflozin-according-to-the-duration-of-heart-failure-a-prespecified-analysis-of-the-deliver-trial
#11
JOURNAL ARTICLE
Toru Kondo, Karola S Jering, C Jan Willem Borleffs, Rudolf A de Boer, Brian L Claggett, Akshay S Desai, Dan Dobreanu, Silvio E Inzucchi, Adrian F Hernandez, Stefan P Janssens, Pardeep Jhund, Mikhail N Kosiborod, Carolyn S P Lam, Anna Maria Langkilde, Felipe A Martinez, Magnus Petersson, Pham Nguyen Vinh, Muthiah Vaduganathan, Scott D Solomon, John J V McMurray
BACKGROUND: How patient characteristics and outcomes vary according to the duration of heart failure (HF) is unknown in individuals with mildly reduced or preserved ejection fraction. We compared these, and the efficacy and safety of dapagliflozin, according to the time from diagnosis of HF in a prespecified analysis of the DELIVER trial (Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure). METHODS: HF duration was categorized as ≤6 months, >6 to 12 months, >1 to 2 years, >2 to 5 years, or >5 years...
March 6, 2023: Circulation
https://read.qxmd.com/read/36871230/comparison-of-3-6-month-versus-12-month-dual-antiplatelet-therapy-after-coronary-intervention-using-the-contemporary-drug-eluting-stents-with-ultrathin-struts-the-host-idea-randomized-clinical-trial
#12
JOURNAL ARTICLE
Jung-Kyu Han, Doyeon Hwang, Seokhun Yang, Sang-Hyeon Park, Jeehoon Kang, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Seung-Ho Hur, Weon Kim, Seok Yeon Kim, Sang-Hyun Park, Seung Hwan Han, Sang-Hyun Kim, Sanghoon Shin, Yong Hoon Kim, Kyungil Park, Namho Lee, Seung Jin Lee, Jin Won Kim, Hyo-Soo Kim
Background: Limited data are available on short-term dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) using third-generation drug-eluting stents (DES) with ultrathin struts and advanced polymer technology. We investigated whether 3-6 month DAPT was non-inferior to 12 month one after implantation of DES with ultrathin struts and advanced polymer technology. Methods: We performed an open-label, randomized trial at 37 centers in South Korea. We enrolled patients undergoing PCI using the Orsiro biodegradable-polymer sirolimus-eluting stents (SES) or the Coroflex ISAR polymer-free SES...
March 5, 2023: Circulation
https://read.qxmd.com/read/36871215/eliminating-medication-copayments-for-low-income-older-adults-at-high-cardiovascular-risk-a-randomized-controlled-trial
#13
JOURNAL ARTICLE
David J T Campbell, Chad Mitchell, Brenda R Hemmelgarn, Marcello Tonelli, Peter Faris, Jianguo Zhang, Ross T Tsuyuki, Jane Fletcher, Flora Au, Scott Klarenbach, Derek V Exner, Braden J Manns
Background: One in eight people with heart disease has poor medication adherence that, in part, is related to copayment costs. This study tested whether eliminating copayments for high-value medications among low-income older adults at high cardiovascular risk would improve clinical outcomes. Methods: This randomized 2x2 factorial trial studied 2 distinct interventions in Alberta, Canada: eliminating copayments for high value preventive medications and a self-management education and support program (reported separately)...
March 5, 2023: Circulation
https://read.qxmd.com/read/36871214/cluster-randomized-trial-of-a-personalized-clinical-decision-support-intervention-to-improve-statin-prescribing-in-patients-with-atherosclerotic-cardiovascular-disease-pcds-statin
#14
LETTER
Salim S Virani, David J Ramsey, Dax Westerman, Mark K Kuebeler, Liang Chen, Julia M Akeroyd, Glenn T Gobbel, Christie M Ballantyne, Laura A Petersen, Alexander Turchin, Michael E Matheny
No abstract text is available yet for this article.
March 5, 2023: Circulation
https://read.qxmd.com/read/36871213/the-effect-of-electronic-nudges-on-influenza-vaccination-rate-in-older-adults-with-cardiovascular-disease-a-prespecified-analysis-of-the-nudge-flu-trial
#15
JOURNAL ARTICLE
Daniel Modin, Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S Bhatt, Simin Gharib Lee, Brian L Claggett, Erica L Dueger, Sandrine I Samson, Matthew M Loiacono, Lars Køber, Scott D Solomon, Pradeesh Sivapalan, Jens Ulrik Stæhr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sørensen
Background: Influenza vaccines have been demonstrated to effectively reduce the incidence of influenza infection and potentially associated risks of cardiovascular events in patients with cardiovascular disease (CVD). Despite strong guideline and public health endorsements, global influenza vaccination rates in patients with CVD are highly variable. This prespecified analysis of NUDGE-FLU (Nationwide Utilization of Danish Government Electronic Letter System for Increasing InFLUenza Vaccine Uptake) examined the effect of digital behavioral nudges on influenza vaccine uptake based on the presence of cardiovascular disease...
March 5, 2023: Circulation
https://read.qxmd.com/read/36871212/self-management-support-using-advertising-principles-for-older-low-income-adults-at-high-cardiovascular-risk-a-randomized-controlled-trial
#16
JOURNAL ARTICLE
David J T Campbell, Marcello Tonelli, Brenda R Hemmelgarn, Peter Faris, Jianguo Zhang, Flora Au, Ross T Tsuyuki, Chad Mitchell, Raj Pannu, Tavis Campbell, Noah Ivers, Jane Fletcher, Derek V Exner, Braden J Manns
Background: Self-management education and support (SMES) interventions have modest effects on intermediate outcomes for those at risk of cardiovascular disease, but few studies have measured or demonstrated an impact on clinical endpoints. Advertising for commercial products is known to influence behavior, but advertising principles are not typically incorporated into SMES design. Methods: This randomized trial studied the impact of a novel tailored SMES program designed by an advertising firm among a population of low-income older adults at high cardiovascular risk in Alberta, Canada...
March 5, 2023: Circulation
https://read.qxmd.com/read/36871211/a-nudge-a-day-keeps-the-influenza-away
#17
EDITORIAL
Bahar Behrouzi, Jacob A Udell
No abstract text is available yet for this article.
March 5, 2023: Circulation
https://read.qxmd.com/read/36870065/on-site-computed-tomography-derived-fractional-flow-reserve-to-guide-the-management-of-patients-with-stable-coronary-artery-disease-the-target-randomized-trial
#18
JOURNAL ARTICLE
Junjie Yang, Dongkai Shan, Xi Wang, Xiaoqing Sun, Meihua Shao, Kan Wang, Yueying Pan, Zhiqiang Wang, U Joseph Schoepf, Rock H Savage, Mei Zhang, Mei Dong, Lei Xu, Yujie Zhou, Xiang Ma, Xinyang Hu, Liming Xia, Hesong Zeng, Zinuan Liu, Yundai Chen
Background: Computed tomography-derived fractional flow reserve (CT-FFR) using on-site machine learning enables identification of both the presence of coronary artery disease and vessel-specific ischemia. However, it is unclear whether on-site CT-FFR improves clinical or economic outcomes when compared with the standard of care in patients with stable coronary artery disease. Methods: In total 1,216 patients with stable coronary artery disease and an intermediate stenosis of 30% to 90% on coronary computed tomographic angiography (CCTA) were randomized to an on-site CT-FFR care pathway using machine learning or to standard care in 6 Chinese medical centers...
March 4, 2023: Circulation
https://read.qxmd.com/read/36866664/comparison-of-unibody-and-non-unibody-endografts-for-abdominal-aortic-aneurysm-repair-in-medicare-beneficiaries-the-safe-aaa-study
#19
JOURNAL ARTICLE
Eric A Secemsky, Yang Song, Tianyu Sun, Carmen Gacchina Johnson, Megan Gatski, Li Wang, Andrew Farb, Robert E Lee, Aurko Shaw, Jiaman Xu, Robert W Yeh
BACKGROUND: Concerns have been raised about the long-term performance of aortic stent grafts for the treatment of abdominal aortic aneurysms, in particular, unibody stent grafts (eg, Endologix AFX AAA stent grafts). Only limited data sets are available to evaluate the long-term risks related to these devices. The SAFE-AAA Study was designed with the Food and Drug Administration to provide a longitudinal assessment of the safety of unibody aortic stent grafts among Medicare beneficiaries...
March 3, 2023: Circulation
https://read.qxmd.com/read/36856044/myocardial-metabolomics-of-human-heart-failure-with-preserved-ejection-fraction
#20
JOURNAL ARTICLE
Virginia S Hahn, Christopher Petucci, Min-Soo Kim, Kenneth C Bedi, Hanghang Wang, Sumita Mishra, Navid Koleini, Edwin J Yoo, Kenneth B Margulies, Zoltan Arany, Daniel P Kelly, David A Kass, Kavita Sharma
BACKGROUND: The human heart primarily metabolizes fatty acids, and this decreases as alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with severe obesity and diabetes are thought to have increased myocardial fatty acid metabolism, but whether this is found in those who also have heart failure with preserved ejection fraction (HFpEF) is unknown. METHODS: Plasma and endomyocardial biopsies were randomly selected from a 2-center derived biobank of HFpEF (n=38), HFrEF (n=30), and nonfailing donor control (n=20) tissue...
March 1, 2023: Circulation
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