Jessica Pfleger, Ryan C Coleman, Jessica Ibetti, Rajika Roy, Ioannis D Kyriazis, Erhe Gao, Konstantinos Drosatos, Walter J Koch
Background: Cardiac hypertrophic growth is mediated by robust changes in gene expression, as well as changes that underlie the increase in cardiomyocyte size. The former is regulated by RNA polymerase (pol) II de novo recruitment or loss, while the latter involves incremental increases in the transcriptional elongation activity of pol II that is preassembled at the transcription start site (TSS). The differential regulation of these distinct processes by transcription factors remains unknown. Forkhead box protein (Fox)O1 is an insulin-sensitive transcription factor, which is also regulated by hypertrophic stimuli in the heart, however, the scope of its gene regulation remains unexplored...
July 9, 2020: Circulation
Ulrich Hanses, Mandy Kleinsorge, Lennart Roos, Gökhan Yigit, Yun Li, Boris Barbarics, Ibrahim El-Battrawy, Huan Lan, Malte Tiburcy, Robin Hindmarsh, Christof Lenz, Gabriela Salinas, Sebastian Diecke, Christian Müller, Ibrahim Adham, Janine Altmüller, Peter Nürnberg, Thomas Paul, Wolfram-Hubertus Zimmermann, Gerd Hasenfuss, Bernd Wollnik, Lukas Cyganek
Background: Noonan syndrome (NS) is a multisystemic developmental disorder characterized by common, clinically variable symptoms, such as typical facial dysmorphisms, short stature, developmental delay, intellectual disability as well as cardiac hypertrophy. The underlying mechanism is a gain-of-function of the RAS-MAP kinase (MAPK) signaling pathway. However, our understanding of the pathophysiological alterations and mechanisms, especially of the associated cardiomyopathy, remains limited and effective therapeutic options are lacking...
July 6, 2020: Circulation
Xiaofeng Li, Jinliang Li, Eliana C Martinez, Alexander Froese, Catherine L Passariello, Kathryn Henshaw, Francesca Rusconi, Yang Li, Qian Yu, Hrishikesh Thakur, Viacheslav O Nikolaev, Michael S Kapiloff
Background: The Ca2+ /calmodulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease. An unexplained paradox is how the Aβ isoform of calcineurin (CaNAβ) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aα expression in the same cells. In addition, it is unclear how the pleiotropic second messenger Ca2+ drives excitation-contraction coupling, while not stimulating hypertrophy via calcineurin in the normal heart. Elucidation of the mechanisms conferring this selectively in calcineurin signaling should reveal new strategies for targeting the phosphatase in disease...
July 2, 2020: Circulation
Yandong Li, Jie Feng, Shen Song, Haotong Li, Huijun Yang, Bin Zhou, Yan Li, Zhang Yue, Hong Lian, Lihui Liu, Shengshou Hu, Yu Nie
Background: A key cause of cardiovascular diseases' high mortality is the cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement functional myocytes for cardiac repair, there is a pressing need to understand the cellular and molecular mechanisms of heart regeneration. Methods: Seven genetic mouse lines were used: global Oncostatin M (OSM) knockout, monocyte-/macrophage-specific OSM deletion, cardiomyocyte-specific lines, including OSMR deletion, gp130 deletion, gp130 activation, and Yap ablation with gp130 activation mice...
June 30, 2020: Circulation
Dan Shao, Stephen C Kolwicz, Pei Wang, Nathan D Roe, Outi Villet, Kiyoto Nishi, Yun-Wei A Hsu, Galina V Flint, Arianne Caudal, Wang Wang, Michael Regnier, Rong Tian
Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obesity/diabetes induced cardiomyopathy. However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain fatty acids transport into mitochondria via deletion of acetyl-CoA carboxylase 2 (ACC2) does not cause cardiomyopathy in non-obese mice, suggesting that high FAO is distinct from cardiac lipotoxicity. We hypothesize that cardiac pathology associated obesity is attributable to the imbalance of fatty acid supply and oxidation...
June 29, 2020: Circulation
Pierre Amarenco, Cristina Hobeanu, Julien Labreuche, Hugo Charles, Maurice Giroud, Elena Meseguer, Philippa C Lavallée, Philippe Gabriel Steg, Éric Vicaut, Eric Bruckert, Pierre-Jean Touboul
Background: The Treat Stroke to Target (TST) trial showed the benefit of targeting a low-density lipoprotein cholesterol (LDL-C) concentration of <70 mg/dL, in term of reducing the risk of major cardiovascular events in 2860 patients with ischemic stroke with atherosclerotic stenosis of cerebral vasculature. The impact on carotid atherosclerosis evolution is not known. Methods: TST-PLUS (Treat Stroke to Target-PLaque Ultrasound Study) included 201 patients assigned to a LDL-C concentration of <70 mg/dL and 212 patients assigned to a target of 100±10 mg/dL...
June 29, 2020: Circulation
Sandra Chamat, Anders Dahl, Lauge Klement Moltke Østergaard, Magnus Arpi, Emil Fosbøl, Jonas Boel, Louise Bruun Oestergaard, Trine K Lauridsen, Gunnar Gislason, Christian Torp-Pedersen, Niels Eske Bruun
Background: Streptococci frequently cause infective endocarditis (IE), yet the prevalence of IE in patients with bloodstream infections (BSIs) caused by different streptococcal species is unknown. We aimed to investigate the prevalence of IE at species level in patients with streptococcal BSIs. Methods: We investigated all patients with streptococcal BSIs, from 2008 to 2017, in the Capital Region of Denmark. Data were crosslinked with Danish nationwide registries for identification of concomitant hospitalization with IE...
June 25, 2020: Circulation
Jakob Raunsø, Rebecca J Song, Ramachandran S Vasan, Maximillian T Bourdillon, Betina Nørager, Christian Torp-Pedersen, Gunnar H Gislason, Vanessa Xanthakis, Charlotte Andersson
Background: Ruptured aortic aneurysm and aortic dissections are potentially preventable disorders associated with high mortality. Screening of individuals at risk may translate into elective surgical interventions and lowered mortality. It is uncertain if the risk of aortic dilation of varying degrees aggregates within families. Methods: We investigated the risk of having thoracic and abdominal aortic sizes in the highest quartile (measured by computed tomography scans and indexed for body size) if at least one parent did so in the Framingham Heart Study (FHS) cohorts, and estimated the incidence rates and hazards ratio of developing aortic aneurysm or dissection among first-degree relatives of those with aortic aneurysm or dissection, as compared with age- and sex-matched controls (1:10 for aortic aneurysm and 1:100 for aortic dissection) using the Danish nationwide administrative registries...
June 25, 2020: Circulation
Daichi Shimbo, Nancy T Artinian, Jan N Basile, Lawrence R Krakoff, Karen L Margolis, Michael K Rakotz, Gregory Wozniak
The diagnosis and management of hypertension, a common cardiovascular risk factor among the general population, have been based primarily on the measurement of blood pressure (BP) in the office. BP may differ considerably when measured in the office and when measured outside of the office setting, and higher out-of-office BP is associated with increased cardiovascular risk independent of office BP. Self-measured BP monitoring, the measurement of BP by an individual outside of the office at home, is a validated approach for out-of-office BP measurement...
June 22, 2020: Circulation
Yujin Lee, Dariush Mozaffarian, Stephen Sy, Junxiu Liu, Parke E Wilde, Matti Marklund, Shafika Abrahams-Gessel, Thomas A Gaziano, Renata Micha
No abstract text is available yet for this article.
June 22, 2020: Circulation
Michelle L O'Donoghue, Sabina A Murphy, Marc S Sabatine
Background: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor has been shown to reduce the risk of MACE compared to aspirin alone after PCI or ACS but with increased risk of bleeding. The safety of discontinuing aspirin in favor of P2Y12 inhibitor monotherapy remains disputed. Methods: A meta-analysis was conducted from randomized trials (2001-2020) that studied discontinuation of aspirin 1-3 months after PCI with continued P2Y12 inhibitor monotherapy compared to traditional DAPT. Five trials were included; follow-up duration ranged from 12-15 months post PCI...
June 19, 2020: Circulation
Peter Willeit, Lena Tschiderer, Elias Allara, Kathrin Reuber, Lisa Seekircher, Lu Gao, Ximing Liao, Eva Lonn, Hertzel C Gerstein, Salim Yusuf, Frank P Brouwers, Folkert W Asselbergs, Wiek van Gilst, Sigmund A Anderssen, Diederick E Grobbee, John J P Kastelein, Frank L J Visseren, George Ntaios, Apostolos I Hatzitolios, Christos Savopoulos, Pythia T Nieuwkerk, Erik Stroes, Matthew Walters, Peter Higgins, Jesse Dawson, Paolo Gresele, Giuseppe Guglielmini, Rino Migliacci, Marat Ezhov, Maya Safarova, Tatyana Balakhonova, Eiichi Sato, Mayuko Amaha, Tsukasa Nakamura, Kostas Kapellas, Lisa M Jamieson, Michael Skilton, James A Blumenthal, Alan Hinderliter, Andrew Sherwood, Patrick J Smith, Michiel A van Agtmael, Peter Reiss, Marit G A van Vonderen, Stefan Kiechl, Gerhard Klingenschmid, Matthias Sitzer, Coen D A Stehouwer, Heiko Uthoff, Zhi-Yong Zou, Ana R Cunha, Mario F Neves, Miles D Witham, Hyun-Woong Park, Moo-Sik Lee, Jang-Ho Bae, Enrique Bernal, Kristian Wachtell, Sverre E Kjeldsen, Michael H Olsen, David Preiss, Naveed Sattar, Edith Beishuizen, Menno V Huisman, Mark A Espeland, Caroline Schmidt, Stefan Agewall, Ercan Ok, Gülay Aşçi, Eric de Groot, Muriel P C Grooteman, Peter J Blankestijn, Michiel L Bots, Michael J Sweeting, Simon G Thompson, Matthias W Lorenz
Background: To quantify the association between effects of interventions on carotid intimamedia thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. Methods: We systematically collated data from randomized controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum value at the common-carotid-artery or other cIMT measures were utilized. The primary outcome was a combined CVD endpoint defined as myocardial infarction, stroke, revascularization procedures, or fatal CVD...
June 17, 2020: Circulation
Shao-Fang Nie, Miao Yu, Tian Xie, Fen Yang, Hong-Bo Wang, Zhao-Hui Wang, Ming Li, Xing-Li Gao, Bing-Jie Lv, Shi-Jia Wang, Xiao-Bo Zhang, Shao-Lin He, Zhi-Hua Qiu, Yu-Hua Liao, Zi-Hua Zhou, Xiang Cheng
No abstract text is available yet for this article.
June 15, 2020: Circulation
Kevin S Shah, Javid J Moslehi, James C Fang
No abstract text is available yet for this article.
June 15, 2020: Circulation
Howard M Julien, Lauren A Eberly, Srinath Adusumalli
No abstract text is available yet for this article.
June 11, 2020: Circulation
John M Simpson, Jane W Newburger
No abstract text is available yet for this article.
June 11, 2020: Circulation
Maria Ercu, Lajos Markó, Carolin Schächterle, Dmitry Tsvetkov, Yingqiu Cui, Sara Maghsodi, Theda U P Bartolomaeus, Philipp G Maass, Kerstin Zühlke, Nerine Gregersen, Norbert Hübner, Russell Hodge, Astrid Mühl, Bärbel Pohl, Rosana Molé-Illas, Andrea Geelhaar, Stephan Walter, Hanna Napieczynska, Stefanie Schelenz, Martin Taube, Arnd Heuser, Yoland-Marie Anistan, Fatimunnisa Qadri, Mihail Todiras, Ralph Plehm, Elena Popova, Reika Langanki, Jenny Eichhorst, Martin Lehmann, Burkhard Wiesner, Michael Russwurm, Sofia K Forslund, Ilona Kamer, Dominik N Müller, Maik Gollasch, Atakan Aydin, Sylvia Bähring, Michael Bader, Friedrich C Luft, Enno Klussmann
Background: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal-dominant hypertension with brachydactyly (HTNB) clinically resembles salt-resistant essential hypertension and causes death by stroke before age 50 years. Recently, we implicated the gene encoding phosphodiesterase 3A ( PDE3A ); however, in vivo modeling of the genetic defect and thus showing an involvement of mutant PDE3A is lacking. Methods: We used genetic mapping, sequencing, transgenic technology, CRISPR-Cas9 gene editing, immunoblotting, and fluorescence resonance energy transfer (FRET)...
June 11, 2020: Circulation
Kasra Moazzami, Matthew T Wittbrodt, Bruno B Lima, Jonathon A Nye, Puja K Mehta, Brad D Pearce, Zakaria Almuwaqqat, Muhammad Hammadah, Oleksiy Levantsevych, Yan V Sun, Paolo Raggi, Ernest V Garcia, Margarethe Goetz, Arshed A Quyyumi, J Douglas Bremner, Viola Vaccarino, Amit J Shah
Background: Psychological stress is a risk factor for major adverse cardiovascular events (MACE) in individuals with coronary artery disease (CAD). Certain brain regions that control both emotional states and cardiac physiology may be involved in this relationship. The rostromedial prefrontal cortex (rmPFC) is an important brain region that processes stress and regulates immune and autonomic functions. Changes in rmPFC activity with emotional stress (reactivity) may be informative of future risk for MACE. Methods: Participants with stable CAD underwent acute mental stress testing using a series of standardized speech/arithmetic stressors and simultaneous brain imaging with high resolution-positron emission tomography brain imaging...
June 11, 2020: Circulation
Aaron L Baggish, Benjamin D Levine
No abstract text is available yet for this article.
June 9, 2020: Circulation
Lauren A Eberly, Sameed Ahmed M Khatana, Ashwin S Nathan, Christopher Snider, Howard M Julien, Mary Elisabeth Deleener, Srinath Adusumalli
No abstract text is available yet for this article.
June 8, 2020: Circulation
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