journal
https://read.qxmd.com/read/34293105/coronary-artery-disease-in-the-absence-of-traditional-risk-factors-a-call-for-action
#1
Suzanne R Avis, Stephen T Vernon, Emil Hagström, Gemma A Figtree
No abstract text is available yet for this article.
July 22, 2021: European Heart Journal
https://read.qxmd.com/read/34291791/in-the-pool-dilution-or-drowning
#2
Victor Dayan, Nick Freemantle, Fabio Barili, Patrick Myers, David Taggart
No abstract text is available yet for this article.
July 22, 2021: European Heart Journal
https://read.qxmd.com/read/34293101/effects-of-canagliflozin-on-human-myocardial-redox-signalling-clinical-implications
#3
Hidekazu Kondo, Ioannis Akoumianakis, Ileana Badi, Nadia Akawi, Christos P Kotanidis, Murray Polkinghorne, Ilaria Stadiotti, Elena Sommariva, Alexios S Antonopoulos, Maria C Carena, Evangelos K Oikonomou, Elsa Mauricio Reus, Rana Sayeed, George Krasopoulos, Vivek Srivastava, Shakil Farid, Surawee Chuaiphichai, Cheerag Shirodaria, Keith M Channon, Barbara Casadei, Charalambos Antoniades
AIMS: Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms remain unknown. We explored the direct effects of canagliflozin, an SGLT2 inhibitor with mild SGLT1 inhibitory effects, on myocardial redox signalling in humans. METHODS AND RESULTS: Study 1 included 364 patients undergoing cardiac surgery. Right atrial appendage biopsies were harvested to quantify superoxide (O2...
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34293083/remnant-cholesterol-predicts-cardiovascular-disease-beyond-ldl-and-apob-a-primary-prevention-study
#4
Renato Quispe, Seth S Martin, Erin D Michos, Isha Lamba, Roger S Blumenthal, Anum Saeed, Joao A C Lima, Rishi Puri, Sarah O Nomura, Michael Y Tsai, John T Wilkins, Christie M Ballantyne, Stephen J Nicholls, Steven R Jones, Mohamed B Elshazly
AIMS: Emerging evidence suggests that remnant cholesterol (RC) promotes atherosclerotic cardiovascular disease (ASCVD). We aimed to estimate RC-related risk beyond low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) in patients without known ASCVD. METHODS AND RESULTS: We pooled data from 17 532 ASCVD-free individuals from the Atherosclerosis Risk in Communities study (n = 9748), the Multi-Ethnic Study of Atherosclerosis (n = 3049), and the Coronary Artery Risk Development in Young Adults (n = 4735)...
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34279617/corrigendum-to-pregnancy-associated-arterial-dissections-a-nationwide-cohort-study
#5
(no author information available yet)
No abstract text is available yet for this article.
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34279606/post-stenting-fractional-flow-reserve-vs-coronary-angiography-for-optimisation-of-percutaneous-coronary-intervention-target-ffr-trial
#6
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-Ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G Oldroyd
AIMS : A fractional flow reserve (FFR) value ≥0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR is an investigator-initiated, single-centre, randomized controlled trial to determine the feasibility and efficacy of a post-PCI FFR-guided optimization strategy vs. standard coronary angiography in achieving final post-PCI FFR values ≥0.90. METHODS AND RESULTS : After angiographically guided PCI, patients were randomized 1:1 to receive a physiology-guided incremental optimization strategy (PIOS) or a blinded coronary physiology assessment (control group)...
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34279605/endocardial-endothelial-angiocrines-regulate-cardiomyocyte-development-and-maturation-and-induce-features-of-ventricular-non-compaction
#7
Siyeon Rhee, David T Paik, Johnson Y Yang, Danielle Nagelberg, Ian Williams, Lei Tian, Robert Roth, Mark Chandy, Jiyeon Ban, Nadjet Belbachir, Seokho Kim, Hao Zhang, Ragini Phansalkar, Ka Man Wong, Devin A King, Caroline Valdez, Virginia D Winn, Ashby J Morrison, Joseph C Wu, Kristy Red-Horse
AIMS: Non-compaction cardiomyopathy is a devastating genetic disease caused by insufficient consolidation of ventricular wall muscle that can result in inadequate cardiac performance. Despite being the third most common cardiomyopathy, the mechanisms underlying the disease, including the cell types involved, are poorly understood. We have previously shown that endothelial cell-specific deletion of the chromatin remodeller gene Ino80 results in defective coronary vessel development that leads to ventricular non-compaction in embryonic mouse hearts...
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34279602/antithrombotic-therapies-in-aortic-and-peripheral-arterial-diseases-in-2021-a-consensus-document-from-the-esc-working-group-on-aorta-and-peripheral-vascular-diseases-the-esc-working-group-on-thrombosis-and-the-esc-working-group-on-cardiovascular-pharmacotherapy
#8
Victor Aboyans, Rupert Bauersachs, Lucia Mazzolai, Marianne Brodmann, José F Rodriguez Palomares, Sebastian Debus, Jean-Philippe Collet, Heinz Drexel, Christine Espinola-Klein, Basil S Lewis, Marco Roffi, Dirk Sibbing, Henrik Sillesen, Eugenio Stabile, Oliver Schlager, Marco De Carlo
The aim of this collaborative document is to provide an update for clinicians on best antithrombotic strategies in patients with aortic and/or peripheral arterial diseases. Antithrombotic therapy is a pillar of optimal medical treatment for these patients at very high cardiovascular risk. While the number of trials on antithrombotic therapies in patients with aortic or peripheral arterial diseases is substantially smaller than for those with coronary artery disease, recent evidence deserves to be incorporated into clinical practice...
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34279030/an-attempt-to-reconcile-the-contrasting-results-of-analyses-on-implantable-cardioverter-defibrillator-shocks-during-the-pandemic
#9
Selçuk Adabag, Mohammad Madjid, Alan Cheng
No abstract text is available yet for this article.
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34279021/acute-mental-stress-drives-vascular-inflammation-and-promotes-plaque-destabilization-in-mouse-atherosclerosis
#10
Julia Hinterdobler, Simin Schott, Hong Jin, Almut Meesmann, Anna-Lena Steinsiek, Anna-Sophia Zimmermann, Jana Wobst, Philipp Müller, Carina Mauersberger, Baiba Vilne, Alexandra Baecklund, Chien-Sin Chen, Aldo Moggio, Quinte Braster, Michael Molitor, Markus Krane, Wolfgang E Kempf, Karl-Heinz Ladwig, Michael Hristov, Maarten Hulsmans, Ingo Hilgendorf, Christian Weber, Philip Wenzel, Christoph Scheiermann, Lars Maegdefessel, Oliver Soehnlein, Peter Libby, Matthias Nahrendorf, Heribert Schunkert, Thorsten Kessler, Hendrik B Sager
AIMS: Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear. METHODS AND RESULTS : Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of acute mental stress. Using cell-tracking experiments in animal models of acute mental stress, we found that stress exposure leads to prompt uptake of inflammatory leucocytes from the blood to distinct tissues including heart, lung, skin, and, if present, atherosclerotic plaques...
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34279020/response-to-discussion-forum-letter-an-attempt-to-reconcile-the-contrasting-results-of-analyses-on-icd-shocks-during-the-pandemic
#11
EDITORIAL
Catherine J O'Shea, Melissa E Middeldorp, Kevin Campbell, Prashanthan Sanders
No abstract text is available yet for this article.
July 19, 2021: European Heart Journal
https://read.qxmd.com/read/34269382/lack-of-specialist-care-is-associated-with-increased-morbidity-and-mortality-in-adult-congenital-heart-disease-a-population-based-study
#12
Gerhard-Paul Diller, Stefan Orwat, Astrid Elisabeth Lammers, Robert M Radke, Fernando De-Torres-Alba, Renate Schmidt, Ursula Marschall, Ulrike M Bauer, Dominic Enders, Leo Bronstein, Gerrit Kaleschke, Helmut Baumgartner
AIMS: The aim of this study was to provide population-based data on the healthcare provision for adults with congenital heart disease (ACHD) and the impact of cardiology care on morbidity and mortality in this vulnerable population. METHODS AND RESULTS: Based on administrative data from one of the largest German Health Insurance Companies, all insured ACHD patients (<70 years of age) were included. Patients were stratified into those followed exclusively by primary care physicians (PCPs) and those with additional cardiology follow-up between 2014 and 2016...
July 16, 2021: European Heart Journal
https://read.qxmd.com/read/34269377/erratum-to-personalized-anti-thrombotic-management-of-patients-with-non-valvular-atrial-fibrillation-and-a-cha2ds2-vasc-score-of-1-a-statement-of-the-esc-working-group-on-cardiovascular-pharmacotherapy-and-esc-council-on-stroke
#13
https://read.qxmd.com/read/34269376/fractional-flow-reserve-derived-from-computed-tomography-coronary-angiography-in-the-assessment-and-management-of-stable-chest-pain-the-forecast-randomized-trial
#14
N Curzen, Z Nicholas, B Stuart, S Wilding, K Hill, J Shambrook, Z Eminton, D Ball, C Barrett, L Johnson, J Nuttall, K Fox, D Connolly, P O'Kane, A Hobson, A Chauhan, N Uren, G P Mccann, C Berry, J Carter, C Roobottom, M Mamas, R Rajani, I Ford, P Douglas, M A Hlatky
AIMS : Fractional flow reserve (FFRCT) using computed tomography coronary angiography (CTCA) determines both the presence of coronary artery disease and vessel-specific ischaemia. We tested whether an evaluation strategy based on FFRCT would improve economic and clinical outcomes compared with standard care. METHODS AND RESULTS : Overall, 1400 patients with stable chest pain in 11 centres were randomized to initial testing with CTCA with selective FFRCT (experimental group) or standard clinical care pathways (standard group)...
July 16, 2021: European Heart Journal
https://read.qxmd.com/read/34269375/predictors-time-course-and-outcomes-of-persistence-patterns-in-oral-anticoagulation-for-non-valvular-atrial-fibrillation-a-dutch-nationwide-cohort-study
#15
Myrthe M A Toorop, Qingui Chen, Vladimir Y I G Tichelaar, Suzanne C Cannegieter, Willem M Lijfering
AIMS : Persistence with direct oral anticoagulants (DOACs) has become a concern in non-valvular atrial fibrillation (NVAF) patients, but whether this affects prognosis is rarely studied. We investigated the persistence with oral anticoagulants (OACs) and its association with prognosis among a nationwide cohort of NVAF patients. METHODS AND RESULTS : DOAC-naive NVAF patients who started to use DOACs for ischaemic stroke prevention between 2013 and 2018 were included using Dutch national statistics...
July 16, 2021: European Heart Journal
https://read.qxmd.com/read/34263911/alpk3-a-full-spectrum-cardiomyopathy-gene
#16
Roddy Walsh, Connie R Bezzina
No abstract text is available yet for this article.
July 15, 2021: European Heart Journal
https://read.qxmd.com/read/34263907/alpha-protein-kinase-3-alpk3-truncating-variants-are-a-cause-of-autosomal-dominant-hypertrophic-cardiomyopathy
#17
Luis R Lopes, Soledad Garcia-Hernández, Massimiliano Lorenzini, Marta Futema, Olga Chumakova, Dmitry Zateyshchikov, Maria Isidoro-Garcia, Eduardo Villacorta, Luis Escobar-Lopez, Pablo Garcia-Pavia, Raquel Bilbao, David Dobarro, Maria Sandin-Fuentes, Claudio Catalli, Blanca Gener Querol, Ainhoa Mezcua, Jose Garcia Pinilla, Torsten Bloch Rasmussen, Ana Ferreira-Aguar, Pablo Revilla-Martí, Maria Teresa Basurte Elorz, Alicia Bautista Paves, Juan Ramon Gimeno, Ana Virginia Figueroa, Raul Franco-Gutierrez, Maria Eugenia Fuentes-Cañamero, Marina Martinez Moreno, Martin Ortiz-Genga, Jesus Piqueras-Flores, Karina Analia Ramos, Ainars Rudzitis, Luis Ruiz-Guerrero, Ricardo Stein, Mayte Triguero-Bocharán, Luis de la Higuera, Juan Pablo Ochoa, Dad Abu-Bonsrah, Cecilia Y T Kwok, Jacob B Smith, Enzo R Porrello, Mohammed M Akhtar, Joanna Jager, Michael Ashworth, Petros Syrris, David A Elliott, Lorenzo Monserrat, Perry M Elliott
AIMS: The aim of this study was to determine the frequency of heterozygous truncating ALPK3 variants (ALPK3tv) in patients with hypertrophic cardiomyopathy (HCM) and confirm their pathogenicity using burden testing in independent cohorts and family co-segregation studies. METHODS AND RESULTS : In a discovery cohort of 770 index patients with HCM, 12 (1.56%) were heterozygous for ALPK3tv [odds ratio(OR) 16.01, 95% confidence interval (CI) 7.89-29.74, P < 8...
July 15, 2021: European Heart Journal
https://read.qxmd.com/read/34263296/persisting-burden-and-challenges-of-rheumatic-heart-disease
#18
Eloi Marijon, Ana Mocumbi, Kumar Narayanan, Xavier Jouven, David S Celermajer
Rheumatic heart disease (RHD) is the result of episodes of acute rheumatic fever with valvular (and other cardiac) damage caused by an abnormal immune response to group A streptococcal infections, usually during childhood and adolescence. As a result of improved living conditions and the introduction of penicillin, RHD was almost eradicated in the developed world by the 1980s. However, being a disease of poverty, its burden remains disproportionately high in the developing world, despite being a fundamentally preventable disease...
July 15, 2021: European Heart Journal
https://read.qxmd.com/read/34254636/clinician-well-being-addressing-global-needs-for-improvements-in-the-health-care-field-a-joint-opinion-from-the-american-college-of-cardiology-american-heart-association-european-society-of-cardiology-world-heart-federation
#19
Laxmi S Mehta, Mitchell S V Elkind, Stephan Achenbach, Fausto J Pinto, Athena Poppas
No abstract text is available yet for this article.
July 13, 2021: European Heart Journal
https://read.qxmd.com/read/34254136/hypercoagulability-and-thrombosis-in-covid-19-a-modifiable-cause-for-mortality
#20
EDITORIAL
Noel Chan, John Eikelboom
No abstract text is available yet for this article.
July 13, 2021: European Heart Journal
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