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European Heart Journal

Alexander R Lyon
No abstract text is available yet for this article.
September 13, 2019: European Heart Journal
Subhi J Al'Aref, Gabriel Maliakal, Gurpreet Singh, Alexander R van Rosendael, Xiaoyue Ma, Zhuoran Xu, Omar Al Hussein Alawamlh, Benjamin Lee, Mohit Pandey, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Jeroen J Bax, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Pedro de Araújo Gonçalves, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Todd C Villines, Heidi Gransar, Yao Lu, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min, Leslee J Shaw
AIMS: Symptom-based pretest probability scores that estimate the likelihood of obstructive coronary artery disease (CAD) in stable chest pain have moderate accuracy. We sought to develop a machine learning (ML) model, utilizing clinical factors and the coronary artery calcium score (CACS), to predict the presence of obstructive CAD on coronary computed tomography angiography (CCTA). METHODS AND RESULTS: The study screened 35 281 participants enrolled in the CONFIRM registry, who underwent ≥64 detector row CCTA evaluation because of either suspected or previously established CAD...
September 12, 2019: European Heart Journal
Masaru Obokata, Garvan C Kane, Yogesh N V Reddy, Vojtech Melenovsky, Thomas P Olson, Petr Jarolim, Barry A Borlaug
AIMS: Pulmonary hypertension (PH) represents an important phenotype among the broader spectrum of patients with heart failure with preserved ejection fraction (HFpEF), but its mechanistic basis remains unclear. We hypothesized that activation of endothelin and adrenomedullin, two counterregulatory pathways important in the pathophysiology of PH, would be greater in HFpEF patients with worsening PH, and would correlate with the severity of haemodynamic derangements and limitations in aerobic capacity and cardiopulmonary reserve...
September 12, 2019: European Heart Journal
Daniel Lancini, Rajesh Shetty
No abstract text is available yet for this article.
September 12, 2019: European Heart Journal
Thomas F Lüscher
No abstract text is available yet for this article.
September 12, 2019: European Heart Journal
Yanguo Xin, Junli Li, Xiaojing Liu
No abstract text is available yet for this article.
September 11, 2019: European Heart Journal
Chun Chin Chang, Kevin M Veen, Rebecca T Hahn, Ad J J C Bogers, Azeem Latib, Frans B S Oei, Mohammad Abdelghani, Rodrigo Modolo, Siew Yen Ho, Mohamed Abdel-Wahab, Khalil Fattouch, Johan Bosmans, Kadir Caliskan, Maurizio Taramasso, Patrick W Serruys, Jeroen J Bax, Nicolas M D A van Mieghem, Johanna J M Takkenberg, Philip Lurz, Thomas Modine, Osama Soliman
Tricuspid regurgitation (TR) is a frequent and complex problem, commonly combined with left-sided heart disease, such as mitral regurgitation. Significant TR is associated with increased mortality if left untreated or recurrent after therapy. Tricuspid regurgitation was historically often disregarded and remained undertreated. Surgery is currently the only Class I Guideline recommended therapy for TR, in the form of annuloplasty, leaflet repair, or valve replacement. As growing experience of transcatheter therapy in structural heart disease, many dedicated transcatheter tricuspid repair or replacement devices, which mimic well-established surgical techniques, are currently under development...
September 11, 2019: European Heart Journal
Marietta Charakida, Georgios Georgiopoulos, Frida Dangardt, Scott T Chiesa, Alun D Hughes, Alicia Rapala, George Davey Smith, Deborah Lawlor, Nicholas Finer, John E Deanfield
No abstract text is available yet for this article.
September 11, 2019: European Heart Journal
Daniele Giacoppo, Fernando Alfonso, Bo Xu, Bimmer E P M Claessen, Tom Adriaenssens, Christoph Jensen, María J Pérez-Vizcayno, Do-Yoon Kang, Ralf Degenhardt, Leos Pleva, Jan Baan, Javier Cuesta, Duk-Woo Park, Heribert Schunkert, Roisin Colleran, Pavel Kukla, Pilar Jiménez-Quevedo, Martin Unverdorben, Runlin Gao, Christoph K Naber, Seung-Jung Park, José P S Henriques, Adnan Kastrati, Robert A Byrne
AIMS: Consensus is lacking regarding the best treatment for coronary in-stent restenosis (ISR). The two most effective treatments are angioplasty with paclitaxel-coated balloon (PCB) and repeat stenting with drug-eluting stent (DES) but individual trials were not statistically powered for clinical endpoints, results were heterogeneous, and evidence about comparative efficacy and safety in relevant subsets was limited. METHODS AND RESULTS: The Difference in Anti-restenotic Effectiveness of Drug-eluting stent and drug-coated balloon AngiopLasty for the occUrrence of coronary in-Stent restenosis (DAEDALUS) study was a comprehensive, investigator-initiated, collaborative, individual patient data meta-analysis comparing angioplasty with PCB alone vs...
September 11, 2019: European Heart Journal
David Messika-Zeitoun, Alec Vahanian, Patrick Verta, Francesco Maisano
No abstract text is available yet for this article.
September 9, 2019: European Heart Journal
Christopher P Cannon
No abstract text is available yet for this article.
September 8, 2019: European Heart Journal
Rafik Tadros, Hanno L Tan, Sulayman El Mathari, Jan A Kors, Pieter G Postema, Najim Lahrouchi, Leander Beekman, Milena Radivojkov-Blagojevic, Ahmad S Amin, Thomas Meitinger, Michael W Tanck, Arthur A Wilde, Connie R Bezzina
AIMS: Sodium-channel blockers (SCBs) are associated with arrhythmia, but variability of cardiac electrical response remains unexplained. We sought to identify predictors of ajmaline-induced PR and QRS changes and Type I Brugada syndrome (BrS) electrocardiogram (ECG). METHODS AND RESULTS: In 1368 patients that underwent ajmaline infusion for suspected BrS, we performed measurements of 26 721 ECGs, dose-response mixed modelling and genotyping. We calculated polygenic risk scores (PRS) for PR interval (PRSPR), QRS duration (PRSQRS), and Brugada syndrome (PRSBrS) derived from published genome-wide association studies and used regression analysis to identify predictors of ajmaline dose related PR change (slope) and QRS slope...
September 3, 2019: European Heart Journal
Emmanuel Sorbets, Kim M Fox, Yedid Elbez, Nicolas Danchin, Paul Dorian, Roberto Ferrari, Ian Ford, Nicola Greenlaw, Paul R Kalra, Zofia Parma, Svetlana Shalnova, Jean-Claude Tardif, Michal Tendera, José Luis Zamorano, Emmanuelle Vidal-Petiot, Philippe Gabriel Steg
AIMS: Over the last decades, the profile of chronic coronary syndrome has changed substantially. We aimed to determine characteristics and management of patients with chronic coronary syndrome in the contemporary era, as well as outcomes and their determinants. METHODS AND RESULTS: Data from 32 703 patients (45 countries) with chronic coronary syndrome enrolled in the prospective observational CLARIFY registry (November 2009 to June 2010) with a 5-year follow-up, were analysed...
September 3, 2019: European Heart Journal
Evangelos K Oikonomou, Michelle C Williams, Christos P Kotanidis, Milind Y Desai, Mohamed Marwan, Alexios S Antonopoulos, Katharine E Thomas, Sheena Thomas, Ioannis Akoumianakis, Lampson M Fan, Sujatha Kesavan, Laura Herdman, Alaa Alashi, Erika Hutt Centeno, Maria Lyasheva, Brian P Griffin, Scott D Flamm, Cheerag Shirodaria, Nikant Sabharwal, Andrew Kelion, Marc R Dweck, Edwin J R Van Beek, John Deanfield, Jemma C Hopewell, Stefan Neubauer, Keith M Channon, Stephan Achenbach, David E Newby, Charalambos Antoniades
BACKGROUND: Coronary inflammation induces dynamic changes in the balance between water and lipid content in perivascular adipose tissue (PVAT), as captured by perivascular Fat Attenuation Index (FAI) in standard coronary CT angiography (CCTA). However, inflammation is not the only process involved in atherogenesis and we hypothesized that additional radiomic signatures of adverse fibrotic and microvascular PVAT remodelling, may further improve cardiac risk prediction. METHODS AND RESULTS: We present a new artificial intelligence-powered method to predict cardiac risk by analysing the radiomic profile of coronary PVAT, developed and validated in patient cohorts acquired in three different studies...
September 3, 2019: European Heart Journal
Gilbert Habib, Paola Anna Erba, Bernard Iung, Erwan Donal, Bernard Cosyns, Cécile Laroche, Bogdan A Popescu, Bernard Prendergast, Pilar Tornos, Anita Sadeghpour, Leopold Oliver, Jolanta-Justina Vaskelyte, Rouguiatou Sow, Olivier Axler, Aldo P Maggioni, Patrizio Lancellotti
AIMS: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). METHODS AND RESULTS: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected...
September 3, 2019: European Heart Journal
Silvia Mas-Peiro, Jedrzej Hoffmann, Stephan Fichtlscherer, Lena Dorsheimer, Michael A Rieger, Stefanie Dimmeler, Mariuca Vasa-Nicotera, Andreas M Zeiher
AIMS: Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities, was recently shown to increase with age and is associated with coronary artery disease and calcification. The most commonly mutated CHIP genes, DNMT3A and TET2, were shown to regulate inflammatory potential of circulating leucocytes. The incidence of degenerative calcified aortic valve (AV) stenosis increases with age and correlates with chronic inflammation...
September 3, 2019: European Heart Journal
Pernille G Thrane, Steen D Kristensen, Kevin K W Olesen, Leif S Mortensen, Hans Erik Bøtker, Leif Thuesen, Henrik S Hansen, Ulrik Abildgaard, Thomas Engstrøm, Henning R Andersen, Michael Maeng
AIMS: The DANish Acute Myocardial Infarction 2 (DANAMI-2) trial found that interhospital transport to primary percutaneous coronary intervention (pPCI) was superior to fibrinolysis at the local hospital in patients with ST-segment elevation myocardial infarction (STEMI) at 30 days. The present study investigates the 16-year cardiovascular outcomes. METHODS AND RESULTS: We randomized 1572 STEMI patients to pPCI or fibrinolysis at 24 referral hospitals and 5 invasive centres in Denmark...
September 2, 2019: European Heart Journal
Marta Czesnikiewicz-Guzik, Grzegorz Osmenda, Mateusz Siedlinski, Richard Nosalski, Piotr Pelka, Daniel Nowakowski, Grzegorz Wilk, Tomasz P Mikolajczyk, Agata Schramm-Luc, Aneta Furtak, Pawel Matusik, Joanna Koziol, Miroslaw Drozdz, Eva Munoz-Aguilera, Maciej Tomaszewski, Evangelos Evangelou, Mark Caulfield, Tomasz Grodzicki, Francesco D'Aiuto, Tomasz J Guzik
AIMS: Inflammation is an important driver of hypertension. Periodontitis is a chronic inflammatory disease, which could provide a mechanism for pro-hypertensive immune activation, but evidence of a causal relationship in humans is scarce. We aimed to investigate the nature of the association between periodontitis and hypertension. METHODS AND RESULTS: We performed a two-sample Mendelian randomization analysis in the ∼750 000 UK-Biobank/International Consortium of Blood Pressure-Genome-Wide Association Studies participants using single nucleotide polymorphisms (SNPs) in SIGLEC5, DEFA1A3, MTND1P5, and LOC107984137 loci GWAS-linked to periodontitis, to ascertain their effect on blood pressure (BP) estimates...
September 1, 2019: European Heart Journal
Luigi M Biasucci, Daniela Pedicino, Giovanna Liuzzo
No abstract text is available yet for this article.
September 1, 2019: European Heart Journal
Patrizio Lancellotti, Patrick Marechal, Nathalie Donis, Cécile Oury
No abstract text is available yet for this article.
September 1, 2019: European Heart Journal
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