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British Journal of Haematology

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https://read.qxmd.com/read/30873599/eltrombopag-induces-major-non-toxic-hypersiderraemia
#1
LETTER
Hélène Caillon, Pierre Peterlin, Patrice Chevallier, Thierry Guillaume, Amandine Lebourgeois, Alice Garnier, Martine Ropert-Bouchet, Thomas Dejoie
No abstract text is available yet for this article.
March 15, 2019: British Journal of Haematology
https://read.qxmd.com/read/30873605/orbital-extramedullary-leukaemia-is-not-a-rare-entity-response-to-paydas
#2
LETTER
Maro Ohanian, Cynthia Tung, Lynne V Abruzzo
No abstract text is available yet for this article.
March 14, 2019: British Journal of Haematology
https://read.qxmd.com/read/30873597/safety-and-diagnostic-yield-of-splenic-core-biopsy-a-methodical-approach-using-combined-haematology-radiology-assessment-in-a-tertiary-referral-centre
#3
LETTER
Katharine Hanlon, Matthew R Wilson, David Kay, Bob Jackson, Mike Leach
No abstract text is available yet for this article.
March 14, 2019: British Journal of Haematology
https://read.qxmd.com/read/30873593/expression-and-function-of-phosphoinositide-3-kinase-delta-in-mesenchymal-stromal-cells-from-normal-and-leukaemic-bone-marrow
#4
Ahmed Y Ali, Qingdong Guan, Xun Wu, Sen Hou, Versha Banerji, James B Johnston, Donna Wall, David Szwajcer, Spencer B Gibson, Aaron J Marshall
Within lymphoid tissues, chronic lymphocytic leukaemia (CLL) cells interact with mesenchymal stromal cells (MSC). Inhibitors of phosphoinositide 3-kinase delta (PI3Kδ) cause release of CLL cells from lymphoid tissues into blood. PI3Kδ inhibitors are thought to target only CLL and other immune cells because PI3Kδ expression is restricted to haematopoietic cells. We found that PI3Kδ is unexpectedly expressed in primary MSC derived from CLL patients and healthy donors. PI3Kδ inhibition in MSC using idelalisib or duvelisib significantly reduced their ability to support CLL migration and adhesion...
March 14, 2019: British Journal of Haematology
https://read.qxmd.com/read/30873584/identification-of-high-risk-dusp22-rearranged-alk-negative-anaplastic-large-cell-lymphoma
#5
LETTER
Greg Hapgood, Susana Ben-Neriah, Anja Mottok, Derrick G Lee, Diego Villa, Laurie H Sehn, Joseph M Connors, Randy D Gascoyne, Andrew L Feldman, Pedro Farinha, Christian Steidl, David W Scott, Graham W Slack, Kerry J Savage
No abstract text is available yet for this article.
March 14, 2019: British Journal of Haematology
https://read.qxmd.com/read/30864168/sustained-treatment-free-remission-in-chronic-myeloid-leukaemia-is-associated-with-an-increased-frequency-of-innate-cd8-t-cells
#6
Emilie Cayssials, Florence Jacomet, Nathalie Piccirilli, Lucie Lefèvre, Lydia Roy, François Guilhot, Jean-Claude Chomel, Xavier Leleu, Jean-Marc Gombert, André Herbelin, Alice Barbarin
Immunological mechanisms of treatment-free remission (TFR) in chronic myeloid leukaemia (CML) are poorly defined and, to date, no correlation between successful TFR and CD8(+) T-cell subsets has been found. We analysed a new identified human subset of CD8(+) T-cells, namely innate CD8(+) T-cells, in CML patients with TFR ≥ 2 years. We demonstrated a dramatic increase of functionally active innate CD8(+) T-cells in these patients as compared to control subjects and patients in remission under tyrosine kinase inhibitors...
March 12, 2019: British Journal of Haematology
https://read.qxmd.com/read/30864164/therapeutic-gene-editing-in-haematological-disorders-with-crispr-cas9
#7
REVIEW
Trine I Jensen, Esben Axelgaard, Rasmus O Bak
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas)9 platform offers an efficient way of making precise genetic changes to the human genome. This can be employed for disruption, addition and correction of genes, thereby enabling a new class of genetic therapies that can be applied to haematological disorders. Here we review recent technological advances in the CRISPR/Cas9 methodology and applications in haematology for curing monogenic genetic disorders and for engineering novel chimeric antigen receptor (CAR) T cells to treat haematological malignancies...
March 12, 2019: British Journal of Haematology
https://read.qxmd.com/read/30864155/the-combination-of-an-inclusive-novel-agent-treatment-strategy-pre-emptive-therapy-dose-reduction-and-prolonged-therapy-results-in-good-outcomes-in-elderly-myeloma-patients
#8
LETTER
Nadishani Ediriwickrama, Titi Oyebamiji, Sreetharan Munisamy, Paula Garland, Kirsty Cuthill, Reuben Benjamin, M Mansour Ceesay, Stella Bowcock
No abstract text is available yet for this article.
March 12, 2019: British Journal of Haematology
https://read.qxmd.com/read/30864154/how-i-manage-patients-with-wiskott-aldrich-syndrome
#9
REVIEW
Elizabeth Rivers, Austen Worth, Adrian J Thrasher, Siobhan O Burns
Wiskott Aldrich syndrome (WAS) is a primary immunodeficiency disease resulting in recurrent infections, eczema and microthrombocytopaenia. In its classical form, significant combined immune deficiency, autoimmune complications and risk of haematological malignancy necessitate early correction with stem cell transplantation or gene therapy. A milder form, X-linked thrombocytopaenia (XLT), shares similar bleeding risk from thrombocytopaenia but is not associated with other significant clinical features and is generally managed conservatively...
March 12, 2019: British Journal of Haematology
https://read.qxmd.com/read/30864146/pet-adapted-therapy-after-three-cycles-of-abvd-for-all-stages-of-hodgkin-lymphoma-results-of-the-gatla-lh-05-trial
#10
Astrid Pavlovsky, Isolda Fernandez, Nicolas Kurgansky, Virginia Prates, Lucia Zoppegno, Pedro Negri, Gustavo Milone, Ider Cerutti, Soledad Zabaljauregui, Romina Mariano, Horacio F Grecco, Ana L Basquiera, Silvia Saba, Silvia Rudoy, Federico Sackmann, Vanesa Castano, Guillermina Remaggi, Maria Cabrejo, Eriberto Roveri, Maria F Casale, Vanina Cabane, Rossana Taus, Claudia Venturini, Francisco Sakamoto, Ana I Varela, Maximiliano Riddick, Santiago Pavlovsky
The role of Ann Arbor staging in determining treatment intensity after achieving a negative positron emission tomography (PET) has not been established in classical Hodgkin lymphoma (cHL). Patients with stage I-IV cHL, received three cycles of ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) and an interim PET scan (PET3). PET3-negative patients received no further therapy. PET3-positive patients received three additional cycles of ABVD plus involved-field radiation therapy or salvage chemotherapy, if refractory to ABVD, and were re-evaluated by PET scan (PET6)...
March 12, 2019: British Journal of Haematology
https://read.qxmd.com/read/30864144/acute-basophilic-leukaemia-secondary-to-mds-with-isolated-del-5q
#11
Inés Loyola, Raquel Fernández, Ariana Trastoy
No abstract text is available yet for this article.
March 12, 2019: British Journal of Haematology
https://read.qxmd.com/read/30859563/sickle-cell-trait-and-renal-disease-among-african-american-u-s-army-soldiers
#12
Jiaqi Hu, D Alan Nelson, Patricia A Deuster, Eric S Marks, Francis G O'Connor, Lianne M Kurina
Sickle cell trait and certain renal disorders are disproportionately prevalent among African American individuals, so a clear understanding of their association is important. We conducted a longitudinal study using the Stanford Military Data Repository to examine sickle cell trait in relation to the incidence of acute kidney injury (AKI) and chronic kidney disease (CKD). Our study population consisted of African American U.S. Army soldiers on active duty between January 2011 and December 2014. The cumulative incidence was 0·51% for AKI (236 cases out of 45 901 soldiers) and 0·56% for CKD (255 cases out of 45 882 soldiers)...
March 11, 2019: British Journal of Haematology
https://read.qxmd.com/read/30859558/risk-of-invasive-pneumococcal-disease-in-children-with-sickle-cell-disease-in-the-era-of-conjugate-vaccines-a-systematic-review-of-the-literature
#13
Godwin Oligbu, Mohammad Fallaha, Leon Pay, Shamez Ladhani
Pneumococcal conjugate vaccines (PCVs) are highly effective in preventing invasive pneumococcal diseases (IPD) in children, including those with sickle cell disease (SCD). A systematic review of the English literature published between 2000 and 2017 was undertaken to evaluate the serotype distribution, clinical presentation and outcomes of IPD in children with SCD in PCV programmes. We identified 475 potential studies and included 16 publications, involving 9438 children up to 22 years of age with SCD and 182 IPD episodes (prevalence, 1·9%...
March 11, 2019: British Journal of Haematology
https://read.qxmd.com/read/30859556/correlation-between-high-serum-alkaline-phosphatase-levels-and-denosumab-related-hypocalcemia-in-patients-with-multiple-myeloma
#14
LETTER
Hirokazu Miki, Shingen Nakamura, Masahiro Oura, Hirofumi Hamano, Kenji Ikuta, Naoto Okada, Yasunobu Okamoto, Kimiko Sogabe, Mamiko Takahashi, Masami Iwasa, Kengo Udaka, Takeshi Harada, Kiyoe Kurahashi, Shiro Fujii, Sumiko Yoshida, Kumiko Kagawa, Itsuro Endo, Ken-Ichi Aihara, Masahiro Abe
No abstract text is available yet for this article.
March 11, 2019: British Journal of Haematology
https://read.qxmd.com/read/30859555/is-venetoclax-a-new-wonder-drug-in-cll
#15
EDITORIAL
Chris Fegan, Chris Pepper
No abstract text is available yet for this article.
March 11, 2019: British Journal of Haematology
https://read.qxmd.com/read/30859554/clonal-haematopoiesis-of-indeterminate-potential-among-cancer-survivors-exposed-to-myelotoxic-chemotherapy
#16
LETTER
Adam J Olszewski, Anna D Chorzalska, Annette S Kim, Peter J Quesenberry, Mary L Lopresti, Mary A Fenton, John L Reagan, James N Butera, Ilyas Sahin, Celine Hamel, Jordan Robison, Max Petersen, Patrycja M Dubielecka
No abstract text is available yet for this article.
March 11, 2019: British Journal of Haematology
https://read.qxmd.com/read/30859551/new-information-on-rare-diseases-how-important-is-that-for-us
#17
EDITORIAL
Keith Gomez
No abstract text is available yet for this article.
March 11, 2019: British Journal of Haematology
https://read.qxmd.com/read/30859549/comparison-of-the-nccn-ipi-the-ipi-and-pit-scores-as-prognostic-tools-in-peripheral-t-cell-lymphomas
#18
LETTER
Fredrik Ellin, Matthew J Maurer, Line Srour, Umar Farooq, Mats Jerkeman, Joseph M Connors, Karin E Smedby, N Nora Bennani, Stephen M Ansell, Graham W Slack, James R Cerhan, Thomas Relander, Andrew L Feldman, Kerry J Savage
No abstract text is available yet for this article.
March 11, 2019: British Journal of Haematology
https://read.qxmd.com/read/30854637/haemolysis-in-sickle-cell-anaemia-effects-of-polymorphisms-in-%C3%AE-globin-gene-regulatory-elements
#19
LETTER
Jacqueline N Milton, Elmutaz M Shaikho, Martin H Steinberg
No abstract text is available yet for this article.
March 10, 2019: British Journal of Haematology
https://read.qxmd.com/read/30854628/tubb1-dysfunction-in-inherited-thrombocytopenia-causes-genome-instability
#20
Takayoshi Matsumura, Ayako Nakamura-Ishizu, Kensuke Takaoka, Hiroaki Maki, Siva S N A Muddineni, Chelsia Q Wang, Hitoshi Suzushima, Makoto Kawakita, Norio Asou, Masao Matsuoka, Mineo Kurokawa, Motomi Osato, Toshio Suda
Inherited thrombocytopenia is a genetically heterogeneous disease characterized by varying degrees of thrombocytopenia and risk of haematological malignancy, and the genetic cause of many cases remains unknown. We performed whole-exome sequencing of a family with thrombocytopenia and myeloid malignancy and identified a novel TUBB1 variant, T149P. Screening of other thrombocytopenia pedigrees identified another TUBB1 variant, R251H. TUBB1 encodes the tubulin β-1 chain, a major component of microtubules abundant in megakaryocytes...
March 10, 2019: British Journal of Haematology
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