journal
https://read.qxmd.com/read/36454546/burkitt-lymphoma-after-solid-organ-transplant-treatment-and-outcomes-in-the-paediatric-ptld-collaborative
#1
JOURNAL ARTICLE
Zeinab Afify, Manuela Orjuela-Grimm, Christine Moore Smith, Mansi Dalal, James B Ford, Pallavi Pillai, Joanna M Robles, Sonika Reddy, Sarah McCormack, Matthew J Ehrhardt, Tonya Ureda, Warren Alperstein, Holly Edington, Tamara P Miller, Jeremy D Rubinstein, Madison Kavanaugh, Andrew J Bukowinski, Erika Friehling, Julie M Rivers, Karen M Chisholm, Lianna J Marks, Clinton C Mason
Burkitt lymphoma arising in paediatric post-solid-organ transplantation-Burkitt lymphoma (PSOT-BL) is a clinically aggressive malignancy and a rare form of post-transplant lymphoproliferative disorder (PTLD). We evaluated 35 patients diagnosed with PSOT-BL at 14 paediatric medical centres in the United States. Median age at organ transplantation was 2.0 years (range: 0.1-14) and age at PSOT-BL diagnosis was 8.0 years (range: 1-17). All but one patient had late onset of PSOT-BL (≥2 years post-transplant), with a median interval from transplant to PSOT-BL diagnosis of 4...
December 1, 2022: British Journal of Haematology
https://read.qxmd.com/read/36454537/current-developmental-screening-practices-in-young-children-with-sickle-cell-disease
#2
JOURNAL ARTICLE
Chibuzo J Aguwa, Alicia D Cannon, James F Casella, Bruce K Shapiro, Eboni I Lance
Despite recent developmental screening guidelines, rates of neurodevelopmental disorders (NDDs) remain lower than expected in children with sickle cell disease (SCD). A retrospective chart review identified 276 eligible patients; 214 charts were available for developmental screening and 207 charts for autism-specific screening. Developmental surveillance/screening was conducted in 70% of charts and autism-specific screening in 19% of charts. Validated tools were used in 32% of developmental screenings and 92% of autism-specific screenings...
December 1, 2022: British Journal of Haematology
https://read.qxmd.com/read/36444962/patient-blood-management-using-dedicated-personnel-in-the-operating-room-you-get-what-you-pay-for
#3
JOURNAL ARTICLE
Richard R Gammon
A patient blood management (PBM) strategy can be applied to the process of intraoperative cell salvage for re-infusion during surgery. Stoneham et al. describe an effective PBM strategy applied to abdominal aortic aneurysm repair and emphasise the importance of a qualified and experienced intraoperative cell salvage practitioner to improve the safety and effectiveness of the approach. Commentary on: Stoneham et al. Intraoperative cell salvage using swab wash and serial thromboelastography in elective abdominal aortic aneurysm surgery involving massive blood loss...
November 29, 2022: British Journal of Haematology
https://read.qxmd.com/read/36444707/a-rare-case-of-primary-cutaneous-anaplastic-large-cell-lymphoma-pc-alcl-localized-to-the-eyelid
#4
JOURNAL ARTICLE
Bambang Atmaja, Thomas Millard, Andrew Wotherspoon, Ayoma D Attygalle, David Cunningham, Bhupinder Sharma
No abstract text is available yet for this article.
November 29, 2022: British Journal of Haematology
https://read.qxmd.com/read/36444480/unusually-high-adamts13-activity-in-a-patient-with-congenital-thrombotic-thrombocytopenic-purpura
#5
LETTER
Maryam Owais Subhan, Rens de Groot, Marie Scully
No abstract text is available yet for this article.
November 28, 2022: British Journal of Haematology
https://read.qxmd.com/read/36444397/effectiveness-and-costs-of-a-stepwise-versus-an-all-in-one-approach-to-diagnose-mild-bleeding-disorders
#6
JOURNAL ARTICLE
Floor C J I Heubel-Moenen, Loes E M Ansems, Paul W M Verhezen, Rick J H Wetzels, Rene G M van Oerle, Ron J M H E Straat, Karyn Megy, Kate Downes, Yvonne M C Henskens, Erik A M Beckers, Manuela A Joore
The diagnostic work-up of patients referred to the haematologist for bleeding evaluation is performed in a stepwise way: bleeding history and results of screening laboratory tests guide further diagnostic evaluation. This can be ineffective, time-consuming and burdensome for patients. To improve this strategy, the initial laboratory investigation can be extended. In a model-based approach, effectiveness and costs of a conventional stepwise versus a newly proposed all-in-one diagnostic approach for bleeding evaluation were evaluated and compared, using data from an observational patient cohort study, including adult patients referred for bleeding evaluation...
November 28, 2022: British Journal of Haematology
https://read.qxmd.com/read/36442510/humoral-response-to-mrna-based-covid-19-vaccine-in-patients-with-immune-thrombocytopenia
#7
JOURNAL ARTICLE
Akio Mori, Masahiro Onozawa, Mirei Kobayashi, Shihori Tsukamoto, Hajime Senjo, Takashi Ishio, Emi Yokoyama, Koh Izumiyama, Makoto Saito, Haruna Muraki, Masanobu Morioka, Takanori Teshima, Takeshi Kondo
Data for COVID-19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 patients with ITP, anti-severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination. The seroconversion rate for ITP patients was 91.3%, comparable to that in healthy controls (HCs). However, the antibody titre in ITP patients was significantly lower than that in HCs and declined with ageing. Furthermore, the antibody titre in ITP patients who received a minimum prednisolone dose of at least 5 mg/day at any time-point at or after initial vaccination was lower than that in other patients...
November 28, 2022: British Journal of Haematology
https://read.qxmd.com/read/36441114/bundles-of-auer-rods-in-mature-neutrophils-in-an-acute-myeloid-leukaemia-patient-with-inv-16-p13-1q22-cbfb-myh-11
#8
JOURNAL ARTICLE
Zolalaina Huberthine Rakotoarivelo, Thomas Lefebvre, Mathilde Lamarque, Inès Harzallah, Agathe Debliquis
No abstract text is available yet for this article.
November 28, 2022: British Journal of Haematology
https://read.qxmd.com/read/36441107/treatment-response-in-acute-myeloid-leukaemia-clues-in-the-biopsy-core
#9
JOURNAL ARTICLE
Alicia G Aguilar Navarro, Anastasia N Tikhonova
In their paper the authors describe distinct transcriptomic changes associated to treatment response in core bone marrow biopsies from patients with acute myeloid leukaemia. This finding raises the possibility that stratifying patients for treatment according to their transcriptomic profiles could improve patients' response and prognosis. Commentary on: Treaba et al. Transcriptomics of AML core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles. Br J Haematol 2022 (Online ahead of print)...
November 28, 2022: British Journal of Haematology
https://read.qxmd.com/read/36413792/a-randomised-evaluation-of-low-dose-ara-c-plus-pegylated-recombinant-arginase-bct-100-versus-low-dose-ara-c-in-older-unfit-patients-with-acute-myeloid-leukaemia-results-from-the-li-1-trial
#10
JOURNAL ARTICLE
Francis Mussai, Carmela De Santo, Paul Cheng, Ian F Thomas, Cono Ariti, Laura Upton, Ugo Scarpa, Victoria Stavrou, Mia Sydenham, Alan K Burnett, Steven K Knapper, Priyanka Mehta, Mary F McMullin, Mhairi Copland, Nigel H Russell, Mike Dennis
The survival of acute myeloid leukaemia (AML) patients aged over 60 has been suboptimal historically, whether they are treated using hypomethylating agents, low-dose cytarabine (LDAC) or venetoclax-based regimens. Progress is being made, however, for subgroups with favourable molecular or cytogenetic findings. Arginine metabolism plays a key role in AML pathophysiology. We report the only randomised study of LDAC with recombinant arginase BCT-100 versus LDAC alone in older AML patients unsuitable for intensive therapy...
November 22, 2022: British Journal of Haematology
https://read.qxmd.com/read/36416009/clinical-utility-of-haematological-inflammatory-biomarkers-in-predicting-30-day-mortality-in-hospitalised-adult-patients-with-covid-19
#11
JOURNAL ARTICLE
Ahmed Embaby, Mohamed Gaber Hamed, Huda Ebian, Lobna A El-Korashi, Mohammad Walaa, Eman M Abd El-Sattar, Amr Shaaban Hanafy, Shimaa Abdelmoneem
Coronavirus disease 2019 (COVID-19) is a multisystem disease affecting respiratory, cardiovascular, gastrointestinal, neurological, immunological and haematological systems. The most important indices that have been studied are platelet (PLT) indices in addition to the PLT count and red blood cell distribution width (RDW). This retrospective study included 95 patients with COVID-19 and was conducted at the Hospital Isolation, Scientific and Medical Research Centre and Clinical Pathology Department at Zagazig University Hospitals, Egypt over 6 months from March to August 2021...
November 21, 2022: British Journal of Haematology
https://read.qxmd.com/read/36410789/congenital-methaemoglobinaemia-and-chronic-haemolysis-related-to-a-rare-form-of-unstable-haemoglobin-efficacy-of-riboflavin-on-clinical-and-biological-features
#12
LETTER
Baptiste Le Calvez, Marine Delecourt-Billet, Audrey Grain, Nathalie Couque, Thierry Leblanc
No abstract text is available yet for this article.
November 21, 2022: British Journal of Haematology
https://read.qxmd.com/read/36408800/management-of-secondary-central-nervous-system-lymphoma
#13
JOURNAL ARTICLE
Kate Cwynarski, Thomas Cummin, Wendy Osborne, Joanne Lewis, Sridhar Chaganti, Jeff Smith, Kim Linton, Paul Greaves, Pam McKay, Christopher P Fox
No abstract text is available yet for this article.
November 21, 2022: British Journal of Haematology
https://read.qxmd.com/read/36408739/why-should-intramuscular-anti-d-be-different-from-intravenous-anti-d
#14
JOURNAL ARTICLE
James B Bussel
For reasons of safety the use of intravenous anti D to treat ITP has largely been abandoned because of the risk it incurs of intravascular haemolysis. Intramuscular delivery of anti-D could be a safer approach and deserves to be further evaluated. IV anti-D was a mainstay of ITP treatment in the United States in the 1990's until the development of intravascular hemolysis (IVH) and its serious even fatal consequences was appreciated. Subsequently, treatment of patients with ITP with IV anti-D has become very rare given other alternatives and the IVH risk...
November 21, 2022: British Journal of Haematology
https://read.qxmd.com/read/36400571/a-comprehensive-seer-registry-analysis-of-elderly-patients-with-classical-hodgkin-lymphoma-based-on-treatment-era-and-race
#15
JOURNAL ARTICLE
Harsh Shah, Hyejeong Jang, Seongho Kim, Ahmad S Halwani
We conducted a Surveillance, Epidemiology, and End Results Program (SEER-18) registry analysis of classical Hodgkin lymphoma (cHL) patients more than 60 years old and compared outcomes of those diagnosed between 2006 and 2010 (cohort 1) to those identified between 2011 and 2015 (cohort 2) based on treatment era and race. Cohort 1 had a median overall survival (OS) of 4 years and cohort 2 had a median OS of 4.75 years [hazard ratio (HR): 0.92 (0.85-1.00); p = 0.052]. Non-Hispanic blacks (NHBs) had a similar 5-year OS compared to non-Hispanic whites (NHWs) of 48...
November 18, 2022: British Journal of Haematology
https://read.qxmd.com/read/36397674/deconstructing-the-liquid-architecture-of-human-herpesvirus-8-diseases
#16
JOURNAL ARTICLE
Mark N Polizzotto
Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma herspesvirus (KSHV), causes several human tumours, which may be associated with systemic inflammation and body cavity effusions, including a form of multicentric Castleman disease (MCD) and a novel inflammatory syndrome, KSHV inflammatory cytokine syndrome (KICS). In this issue, Zhou et al. demonstrate that HHV-8-infected lambda-restricted plasmablasts can be detected in these effusions and can be used to distinguish MCD from other HHV-8 tumours as well as to categorise KICS into distinct clinicopathological groups...
November 17, 2022: British Journal of Haematology
https://read.qxmd.com/read/36385618/human-leukocyte-antigen-evolutionary-divergence-influences-outcomes-of-paediatric-patients-and-young-adults-affected-by-malignant-disorders-given-allogeneic-haematopoietic-stem-cell-transplantation-from-unrelated-donors
#17
JOURNAL ARTICLE
Pietro Merli, Pietro Crivello, Luisa Strocchio, Rita Maria Pinto, Mattia Algeri, Francesca Del Bufalo, Daria Pagliara, Marco Becilli, Roberto Carta, Stefania Gaspari, Federica Galaverna, Francesco Quagliarella, Giulia Boz, Maria Luigia Catanoso, Emilia Boccieri, Maria Troiano, Katharina Fleischhauer, Marco Andreani, Franco Locatelli
High genetic heterogeneity in the human leukocyte antigen (HLA) increases the likelihood of efficient immune response to pathogens and tumours. As measure of HLA diversity, HLA evolutionary divergence (HED) has been shown to predict the response of tumours to immunotherapy and haematopoietic stem cell transplantation (HSCT) in adults. We retrospectively investigated the association of HED with outcomes of 153 paediatric/young adults patients, treated for malignant disorders with HSCT from 9-10/10 HLA-matched unrelated donors...
November 16, 2022: British Journal of Haematology
https://read.qxmd.com/read/36385372/t-9-12-q22-p13-etv6-syk-a-new-recurrent-cytogenetic-aberration-and-tyrosine-kinase-gene-fusion-in-myeloid-or-lymphoid-neoplasms-associated-with-eosinophilia
#18
LETTER
Els Lierman, Sanne Smits, Koen Debackere, Marc André, Lucienne Michaux, Peter Vandenberghe
No abstract text is available yet for this article.
November 16, 2022: British Journal of Haematology
https://read.qxmd.com/read/36382698/antibody-response-to-a-third-sars-cov-2-vaccine-dose-in-recipients-of-an-allogeneic-haematopoietic-cell-transplantation
#19
JOURNAL ARTICLE
Andriyana K Bankova, Chloé Pasin, Alice Huang, Caroline Cicin-Sain, Selina Epp, Annette Audige, Nicolas J Mueller, Jakob Nilsson, Oliver Vilinovszki, Gayathri Nair, Nathan Wolfensberger, Philipp Hockl, Urs Schanz, Alexandra Trkola, Roger Kouyos, Barbara Hasse, Annelies S Zinkernagel, Markus G Manz, Irene A Abela, Antonia M S Müller
Allogeneic haematopoietic cell transplantation (allo-HCT) recipients show impaired antibody (Ab) response to a standard two-dose vaccination against severe acute respiratory syndrome coronavirus-2 and currently a third dose is recommended as part of the primary vaccination regimen. By assessing Ab titres 1 month after a third mRNA vaccine dose in 74 allo-HCT recipients we show sufficient neutralisation activity in 77% of the patients. Discontinuation of immunosuppression before the third vaccine led to serological responses in 50% of low responders to two vaccinations...
November 16, 2022: British Journal of Haematology
https://read.qxmd.com/read/36382420/characterising-the-prevalence-of-overweight-and-obese-status-among-adults-with-sickle-cell-disease
#20
JOURNAL ARTICLE
Stephanie O Ibemere, Charity I Oyedeji, Liliana Preiss, Laura E Van Althuis, Jane S Hankins, Melissa Azul, Ebony N Burns, Jeffrey Glassberg, Ward Hagar, Faiz Hussain, Allison King, Cathy Melvin, John Myers, Angela Snyder, Nirmish Shah, Paula Tanabe
Individuals with sickle cell disease (SCD) have historically been considered underweight. Despite increasing body mass index (BMI) in the general population, the prevalence of overweight and obese status remains unclear in the adult SCD population. Our primary aim was to determine the prevalence of overweight and obese status and to identify associations between BMI, demographic, and clinical characteristics. We conducted an analysis of abstracted electronic health record data and patient-reported outcomes from the Sickle Cell Disease Implementation Consortium registry; individuals aged 20-45 years were included...
November 16, 2022: British Journal of Haematology
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