journal

British Journal of Haematology

journal
https://read.qxmd.com/read/31702836/lenalidomide-maintenance-for-diffuse-large-b-cell-lymphoma-patients-responding-to-r-chop-quality-of-life-dosing-and-safety-results-from-the-randomised-controlled-remarc-study
#1
Catherine Thieblemont, Susannah Howlett, René-Olivier Casasnovas, Nicolas Mounier, Aurore Perrot, Franck Morschhauser, Christophe Fruchart, Nicolas Daguindau, Koen van Eygen, Lucie Obéric, Reda Bouabdallah, Gian Matteo Pica, Emmanuelle Nicolas-Virezelier, Julie Abraham, Olivier Fitoussi, Sylvia Snauwaert, Jean-Claude Eisenmann, Pauline Lionne-Huyghe, Dominique Bron, Sabine Tricot, Dries Deeren, Hugo Gonzalez, Régis Costello, Katell Le Du, Maria Gomes da Silva, Sebastian Grosicki, Judith Trotman, John Catalano, Dolores Caballero, Richard Greil, Amos M Cohen, Philippe Gaulard, Louise Roulin, Kenichi Takeshita, Marie-Laure Casadebaig, Hervé Tilly, Bertrand Coiffier
Lenalidomide maintenance therapy prolonged progression-free survival (PFS) versus placebo in elderly patients with diffuse large B-cell lymphoma (DLBCL) responding to induction chemotherapy in the phase 3 REMARC study. This subpopulation analysis assessed the impact of lenalidomide maintenance and treatment-emergent adverse events (TEAEs) on health-related quality of life (HRQOL). Global health status (GHS), and physical functioning and fatigue subscales were evaluated in patients who completed the European Organisation for Research and Treatment of Cancer quality-of-life questionnaire-C30 v3...
November 8, 2019: British Journal of Haematology
https://read.qxmd.com/read/31702832/allogeneic-haematopoietic-cell-transplantation-after-car-t-cell-therapy-safe-effective-and-contentious
#2
EDITORIAL
Bhagirathbhai Dholaria, Bipin N Savani
No abstract text is available yet for this article.
November 8, 2019: British Journal of Haematology
https://read.qxmd.com/read/31702049/increased-frequency-of-cd4-pd-1-hla-dr-t-cells-is-associated-with-disease-progression-in-cll
#3
Lauren Elston, Chris Fegan, Robert Hills, Shaikh S Hashimdeen, Elisabeth Walsby, Peter Henley, Chris Pepper, Stephen Man
Chronic lymphocytic leukaemia (CLL) patients often have abnormal expansions of CD4+ and CD8+ T cells and this can be associated with progressive disease. To characterise the key T-cell populations involved in this phenomenon, we used flow cytometry and 11 phenotypic markers to study 74 CLL patients and 14 controls. T cells of CLL patients were more phenotypically complex than those of healthy controls with significant increases in the frequencies of CD4 and CD8 memory T cells expressing exhaustion-, activation- and senescence-associated markers...
November 8, 2019: British Journal of Haematology
https://read.qxmd.com/read/31702048/very-late-relapse-with-rapid-bcr-abl1-elevation-after-more-than-seven-years-of-treatment-free-remission-with-undetectable-molecular-residual-disease-in-chronic-myeloid-leukaemia
#4
LETTER
Seiichiro Katagiri, Akihiko Gotoh, Kazuma Ohyashiki
No abstract text is available yet for this article.
November 8, 2019: British Journal of Haematology
https://read.qxmd.com/read/31696941/platelet-biology-of-the-rapidly-failing-lung
#5
A Valance Washington, Omar Esponda, Angelia Gibson
Acute respiratory distress syndrome (ARDS) is characterized by a rapid-onset respiratory failure with a mortality rate of approximately 40%. This physiologic inflammatory process is mediated by disruption of the alveolar-vascular interface, leading to pulmonary oedema and impaired oxygen exchange, which often warrants mechanical ventilation to increase survival in the acute setting. One of the least understood aspects of ARDS is the role of the platelets in this process. Platelets, which protect vascular integrity, play a pivotal role in the progression and resolution of ARDS...
November 7, 2019: British Journal of Haematology
https://read.qxmd.com/read/31696939/improved-survival-after-offspring-donor-transplant-compared-with-older-aged-matched-siblings-for-older-leukaemia-patients
#6
Yu Wang, Qi-Fa Liu, De-Pei Wu, Lan-Ping Xu, Kai-Yan Liu, Xiao-Hui Zhang, Sheng-Ye Lu, Xiao Ma, Fen Huang, Xiao-Jun Huang
Donor selection for older leukaemia patients undergoing haematopoietic cell transplant (HCT) is not well defined: outcomes might be improved with a younger offspring donor rather than an older human leukocyte antigen (HLA)-matched sibling donor (MSD). We extended our multicentre dataset. A total of 185 acute leukaemia patients (≥ 50 years) transplanted in first complete remission who received HCT from offspring (n = 62) or MSD (n = 123) were included. A 1:1 ratio matched-pair analysis was performed...
November 7, 2019: British Journal of Haematology
https://read.qxmd.com/read/31693175/treatment-of-acute-leukaemia-in-adult-jehovah-s-witnesses
#7
REVIEW
Firas El Chaer, Karen K Ballen
Since Jehovah's Witness (JW) patients diagnosed with leukaemia refuse blood transfusions, they are often denied intensive chemotherapy for fear they could not survive myeloablation without blood transfusion support. Treatment of JW patients with acute leukaemia is challenging and carries a higher morbidity and mortality; however, the refusal of blood products should not be an absolute contraindication to offer multiple treatment modalities including haematopoietic stem cell transplantation. In this review we discuss their optimal management and describe alternative modalities to blood transfusions to provide sufficient oxygenation and prevent bleeding...
November 6, 2019: British Journal of Haematology
https://read.qxmd.com/read/31693163/intestinal-pathophysiological-and-microbial-changes-in-sickle-cell-disease-potential-targets-for-therapeutic-intervention
#8
REVIEW
Dibyendu Dutta, Amandeep Aujla, Bettina M Knoll, Seah H Lim
There is a large therapeutic gap in the treatment of sickle cell disease (SCD). Recent studies demonstrated the presence of pathophysiological and microbial changes in the intestine of patients with SCD. The intestinal microbes have also been found to regulate neutrophil ageing and possible basal activation of circulating neutrophils. Both aged and activated neutrophils are pivotal for the pathogenesis of vaso-occlusive crisis in SCD. In this paper, we will provide an overview of the intestinal pathophysiological and microbial changes in SCD...
November 6, 2019: British Journal of Haematology
https://read.qxmd.com/read/31682006/primary-therapy-and-survival-among-patients-with-nodular-lymphocyte-predominant-hodgkin-lymphoma-a-population-based-analysis-in-the-netherlands-1993-2016
#9
Hidde L A Posthuma, Josée M Zijlstra, Otto Visser, Pieternella J Lugtenburg, Marie José Kersten, Avinash G Dinmohamed
In this nationwide, population-based study, we assessed trends in primary treatment and survival among 687 patients with nodular lymphocyte-predominant Hodgkin lymphoma (75% males; median age, 40 years; and 74% stage-I/II disease) diagnosed in the Netherlands between 1993-2016. There were no noteworthy changes in the application of primary therapy over time among adult patients across the different disease stages and age groups. Survival among various subgroups of adult patients was largely comparable to the expected survival of the general population...
November 4, 2019: British Journal of Haematology
https://read.qxmd.com/read/31682002/the-efficacy-and-safety-of-venetoclax-therapy-in-elderly-patients-with-relapsed-refractory-chronic-lymphocytic-leukaemia
#10
Toby A Eyre, Lindsey E Roeker, Christopher P Fox, Satyen H Gohill, Renata Walewska, Harriet S Walter, Francesco Forconi, Angus Broom, Arvind Arumainathan, Danielle M Brander, John N Allan, Stephen J Schuster, Brian T Hill, Frederick Lansigan, Bruce D Cheson, Nicole Lamanna, Catherine C Coombs, Paul M Barr, Alan P Skarbnik, Mazyar Shadman, Chaitra S Ujjani, Laurie Pearson, John M Pagel, Ryan Jacobs, Anthony R Mato
Elderly chronic lymphocytic leukaemia (CLL) patients treated outside of trials have notably greater toxicity with the Bruton's tyrosine kinase inhibitor ibrutinib compared to younger patients. It is not known whether the same holds true for the B-cell lymphoma 2 inhibitor venetoclax. We provide a comprehensive analysis of key safety measures and efficacy in 342 patients comparing age categories ≥75 and <75 years treated in the relapsed, refractory non-trial setting. We demonstrate that venetoclax has equivalent efficacy and safety in relapsed/refractory CLL patients who are elderly, the majority of whom are previous ibrutinib-exposed and therefore may otherwise have few clear therapeutic options...
November 4, 2019: British Journal of Haematology
https://read.qxmd.com/read/31681999/co-occurrence-of-bcr-abl1-positive-chronic-myeloid-leukaemia-and-calr-mutated-essential-thrombocythaemia
#11
LETTER
Victor E F da Costa, Rafael D de Oliveira, Fabíola Traina, Fernando Chahud, Leonardo C Palma, Lorena L de Figueiredo-Pontes
No abstract text is available yet for this article.
November 4, 2019: British Journal of Haematology
https://read.qxmd.com/read/31681986/fla-ida-salvage-chemotherapy-combined-with-a-seven-day-course-of-venetoclax-flavida-in-patients-with-relapsed-refractory-acute-leukaemia
#12
LETTER
Rabia Shahswar, Gernot Beutel, Piroska Klement, Alina Rehberg, Razif Gabdoulline, Christian Koenecke, Dominik Markel, Hendrik Eggers, Matthias Eder, Michael Stadler, Lothar Hambach, Steve Ehrlich, Gudrun Göhring, Brigitte Schlegelberger, Elke Dammann, Marlene Reuter, Martin Wichmann, Blerina Neziri, Arnold Ganser, Felicitas Thol, Michael Heuser
No abstract text is available yet for this article.
November 4, 2019: British Journal of Haematology
https://read.qxmd.com/read/31680237/another-disappointment-in-treating-relapsed-refractory-high-risk-aggressive-b-cell-lymphomas
#13
EDITORIAL
Toby A Eyre
No abstract text is available yet for this article.
November 4, 2019: British Journal of Haematology
https://read.qxmd.com/read/31674662/human-leukocyte-antigen-hla-class-i-antibodies-and-transfusion-support-in-paediatric-hla-matched-haematopoietic-cell-transplant-for-sickle-cell-disease
#14
Robert S Nickel, John T Horan, Allistair Abraham, Muna Qayed, Ann Haight, Alexander Ngwube, Hua Liang, Naomi L C Luban, Jeanne E Hendrickson
The relevance of donor-specific human leukocyte antigen (HLA) antibodies in HLA-mismatched haematopoietic cell transplant (HCT) is known, but the importance of HLA antibodies in HLA-matched HCT is unclear. We hypothesized that HLA antibodies detected before HCT would cause platelet transfusion refractoriness during HCT and investigated this in a multi-centre study. Pre-HCT samples from 45 paediatric patients with sickle cell disease (SCD) undergoing HLA-matched HCT were tested for HLA class I antibodies. The number of platelet transfusions received before day +45 was compared between those with and without antibodies...
November 1, 2019: British Journal of Haematology
https://read.qxmd.com/read/31650539/identification-of-essential-exported-plasmodium-falciparum-protein-kinases-in-malaria-infected-red-blood-cells
#15
Ghizal Siddiqui, Nicholas I Proellochs, Brian M Cooke
FIKK kinases in the human malaria parasite Plasmodium falciparum are attractive targets for new anti-malaria drugs, as they have no orthologues in humans and have been linked to disease severity. Six FIKKs are known to be exported into red blood cells (RBCs) where they mediate dramatic structural and functional changes to RBCs that are central to pathogenesis. Eleven members of this family, which are predicted to be exported into infected RBCs (iRBCs), remain uncharacterised. Using a targeted gene-knockout approach, we have characterised these FIKKs and discovered that five are essential for parasite survival...
October 24, 2019: British Journal of Haematology
https://read.qxmd.com/read/31625161/cystic-lung-disease-with-kappa-light-chain-deposition-in-newly-diagnosed-multiple-myeloma
#16
Robert C Clayden, Denis Macdonald, Anastasia Oikonomou, Matthew C Cheung
No abstract text is available yet for this article.
October 17, 2019: British Journal of Haematology
https://read.qxmd.com/read/31625136/autoimmune-conditions-and-primary-central-nervous-system-lymphoma-risk-among-older-adults
#17
Parag Mahale, Megan M Herr, Eric A Engels, Ruth M Pfeiffer, Meredith S Shiels
Primary central nervous system lymphoma (PCNSL) risk is highly increased in immunosuppressed individuals, such as those with human immunodeficiency virus infection and solid organ transplant recipients, but rates are increasing among immunocompetent older adults (age ≥65 years). We utilized data from a large, nationally-representative cohort of older adults in the United States and found that PCNSL is significantly associated with systemic lupus erythematosus, polyarteritis nodusa, autoimmune hepatitis, myasthenia gravis and uveitis...
October 17, 2019: British Journal of Haematology
https://read.qxmd.com/read/31621066/bk-virus-nephropathy-without-haemorrhagic-cystitis-following-bone-marrow-transplantation
#18
Rosanna Ghinai, Judit Sutak, Moin Saleem, John Moppett
No abstract text is available yet for this article.
October 16, 2019: British Journal of Haematology
https://read.qxmd.com/read/31621063/spanish-guidelines-for-the-use-of-targeted-deep-sequencing-in-myelodysplastic-syndromes-and-chronic-myelomonocytic-leukaemia
#19
LETTER
Laura Palomo, Mariam Ibáñez, María Abáigar, Iria Vázquez, Sara Álvarez, Marta Cabezón, Bárbara Tazón-Vega, Inmaculada Rapado, Francisco Fuster-Tormo, José Cervera, Rocío Benito, María J Larrayoz, Juan C Cigudosa, Lurdes Zamora, David Valcárcel, María T Cedena, Pamela Acha, Jesús M Hernández-Sánchez, Marta Fernández-Mercado, Guillermo Sanz, Jesús M Hernández-Rivas, María J Calasanz, Francesc Solé, Esperanza Such
The landscape of medical sequencing has rapidly changed with the evolution of next generation sequencing (NGS). These technologies have contributed to the molecular characterization of the myelodysplastic syndromes (MDS) and chronic myelomonocytic leukaemia (CMML), through the identification of recurrent gene mutations, which are present in >80% of patients. These mutations contribute to a better classification and risk stratification of the patients. Currently, clinical laboratories include NGS genomic analyses in their routine clinical practice, in an effort to personalize the diagnosis, prognosis and treatment of MDS and CMML...
October 16, 2019: British Journal of Haematology
https://read.qxmd.com/read/31621058/venetoclax-induced-tumour-lysis-syndrome-in-acute-myeloid-leukaemia
#20
LETTER
Sonia Esparza, Benyam Muluneh, Jonathan Galeotti, Melissa Matson, Daniel R Richardson, Nathan D Montgomery, Catherine C Coombs, Katarzyna Jamieson, Matthew C Foster, Joshua F Zeidner
No abstract text is available yet for this article.
October 16, 2019: British Journal of Haematology
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