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British Journal of Haematology

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https://read.qxmd.com/read/31099035/utility-of-fibrinogen-in-the-coagulation-screen
#1
LETTER
Christopher Tham, Kurtis Lee, Mike Laffan
No abstract text is available yet for this article.
May 16, 2019: British Journal of Haematology
https://read.qxmd.com/read/31099033/possibility-of-a-risk-adapted-treatment-strategy-for-untreated-aggressive-adult-t-cell-leukaemia-lymphoma-atl-based-on-the-atl-prognostic-index-a-supplementary-analysis-of-the-jcog9801
#2
Kosuke Toyoda, Kunihiro Tsukasaki, Ryunosuke Machida, Tomohiro Kadota, Takuya Fukushima, Kenji Ishitsuka, Dai Maruyama, Hirokazu Nagai
JCOG9801, a randomized phase III trial, reported that vincristine, cyclophosphamide, doxorubicin and prednisone (VCAP); doxorubicin, ranimustine and prednisone (AMP); and vindesine, etoposide, carboplatin and prednisone (VECP) (VCAP-AMP-VECP; mLSG15) showed superior clinical outcomes when compared to cyclophosphamide, doxorubicin, vincristine and prednisone every 2 weeks (CHOP-14; mLSG19) in patients with untreated aggressive adult T-cell leukaemia-lymphoma (ATL). To identify patients who require VCAP-AMP-VECP, we conducted a supplementary analysis of JCOG9801...
May 16, 2019: British Journal of Haematology
https://read.qxmd.com/read/31090926/essential-thrombocythaemia-treated-with-recombinant-interferon-real-world-united-kingdom-referral-centre-experience
#3
Joana Desterro, Donal P McLornan, Natalia Curto Garcia, Jennifer O'Sullivan, Samah Alimam, Clodagh Keohane, Claire Woodley, Yvonne Francis, Shahram Kordasti, Deepti H Radia, Claire N Harrison
Standard first-line therapy choice for essential thrombocythaemia (ET) requiring cytoreduction, supported by randomized trials, is low-dose aspirin with hydroxycarbamide, but the role of recombinant interferon-alfa (IFNα)-2a/2b and pegylated (PEG)-IFN-α-2a/2b is increasingly highlighted. Longer-term outcome data, however, remains somewhat scarce, particularly in the 'real world'. We hereby report on a large, well-annotated cohort of ET patients from a single referral centre undergoing therapy with either IFNα or (PEG)-IFN-α-2a/2b and demonstrate high rates of complete haematological responses, good tolerability and safety, low rates of thromboembolic events in compliant patients and confirm feasibility of long-term therapy in a significant proportion of patients...
May 15, 2019: British Journal of Haematology
https://read.qxmd.com/read/31090920/reduced-intensity-allogeneic-stem-cell-transplantation-for-younger-patients-with-myelofibrosis
#4
REVIEW
Daniele Mannina, Tatjana Zabelina, Christine Wolschke, Marion Heinzelmann, Ioanna Triviai, Maximilian Christopeit, Anita Badbaran, Stefan Bonmann, Ute-Marie von Pein, Dietlinde Janson, Francis Ayuk, Nicolaus Kröger
Allogeneic stem cell transplantation (alloSCT) is a curative procedure for myelofibrosis. Elderly people are mainly affected, limiting the feasibility of myeloablative regimens. The introduction of reduced-intensity conditioning (RIC) made alloSCT feasible for older patients. Nevertheless, the incidence of myelofibrosis is not negligible in young patients, who are theoretically able to tolerate high-intensity therapy. Very few data are available about the efficacy of RIC-alloSCT in younger myelofibrosis patients...
May 15, 2019: British Journal of Haematology
https://read.qxmd.com/read/31090916/setting-up-a-national-infrastructure-for-survivorship-care-after-treatment-for-hodgkin-lymphoma
#5
LETTER
Annelies Nijdam, Nicky Dekker, Berthe M P Aleman, Mars B van 't Veer, Laurien A Daniels, Richard W van der Maazen, Cecile P M Janus, Roel J de Weijer, Josée M Zijlstra, Floriske G Stedema, Bastiaan D Ta, Eduardus F M Posthuma, Annelies Manenschijn, Michel F H Dielwart, Yavuz M Bilgin, Maaike J van den Heuvel, Rinske S Boersma, Flora E van Leeuwen, John M M Raemaekers
No abstract text is available yet for this article.
May 15, 2019: British Journal of Haematology
https://read.qxmd.com/read/31090915/pembrolizumab-combined-with-lenalidomide-and-low-dose-dexamethasone-for-relapsed-or-refractory-multiple-myeloma-phase-i-keynote-023-study
#6
LETTER
Maria-Victoria Mateos, Robert Z Orlowski, Enrique M Ocio, Paula Rodríguez-Otero, Donna Reece, Philippe Moreau, Nikhil Munshi, David E Avigan, David S Siegel, Razi Ghori, Mohammed Z H Farooqui, Patricia Marinello, Jesus San-Miguel
No abstract text is available yet for this article.
May 15, 2019: British Journal of Haematology
https://read.qxmd.com/read/31087331/next-generation-sequencing-redefines-a-triple-negative-essential-thrombocythaemia-as-double-positive-with-rare-mutations-on-jak2-v617-and-mpl-w515-hotspots
#7
LETTER
Annaëlle Beucher, Mammoun Dib, Corentin Orvain, Anne Bouvier, Rebecca Jouanneau-Courville, Irène Dobo, Laurane Cottin, Philippe Guardiola, Marie-Christine Rousselet, Odile Blanchet, Mathilde Hunault, Valérie Ugo, Damien Luque Paz
No abstract text is available yet for this article.
May 14, 2019: British Journal of Haematology
https://read.qxmd.com/read/31069799/how-i-treat-children-with-haemophilia-and-inhibitors
#8
REVIEW
Guy Young
Haemophilia is a serious inherited bleeding disorder resulting from a deficiency of coagulation factor VIII (haemophilia A) or coagulation factor IX (haemophilia B). While effective therapies have been developed to replace the missing factor and restore normal coagulation, they can lead to the development of neutralizing anti-drug antibodies, termed inhibitors, which significantly worsen morbidity and quality of life. While advancements have been made to improve the management of patients, and particularly for this review, children with inhibitors, there remain significant unmet needs including inhibitor prevention, inhibitor eradication and, when those fail, more effective bleed prevention and a reduction in the treatment burden...
May 9, 2019: British Journal of Haematology
https://read.qxmd.com/read/31069789/rituximab-and-reduced-intensity-chemotherapy-in-children-and-adolescents-with-mature-b-cell-lymphoma-interim-results-for-231-patients-enrolled-in-the-second-russian-belorussian-multicentre-study-b-nhl-2010m
#9
Alexey Maschan, Natalia Myakova, Olga Aleinikova, Yulia Abugova, Natalia Ponomareva, Margarita Belogurova, Larisa Fechina, Alina Fedorova, Natalia Grigor'eva, Vladimir Lebedev, Olga Nikonova, Anastassia Shamardina, Guzel Sharapova, Nadezhda Smirnova, Anastassia Rudneva, Egor Volchkov, Elena Samochatova
The value of adding rituximab to chemotherapy in children with aggressive B-cell non-Hodgkin lymphoma (B-NHL) is still insufficiently studied. We enrolled 231 patients [mean age 9 years old (range 2-17); male:female ratio 3·4:1] with Burkitt (BL, 179 patients, 76·7%), diffuse large B-cell (32 patients, 14%), primary mediastinal B-cell (14 patients, 6%), and other (6 patients, 2·6%) B-cell lymphomas in a prospective study of immuno-chemotherapy. Stages were I-II in 32% and III-IV in 68% of the patients. Four doses of 375 mg/m2 rituximab were added to the Berlin-Frankfurt-Munster-NHL-90-like chemotherapy, with methotrexate being reduced or omitted in the first 2 induction blocks...
May 9, 2019: British Journal of Haematology
https://read.qxmd.com/read/31069785/myeloid-sarcoma-deciphering-a-rare-cause-of-cardiac-compromise
#10
Naoimh Herlihy, Emma M Groarke, Johnny McHugh, Helen Enright, Eibhlin Conneally
No abstract text is available yet for this article.
May 9, 2019: British Journal of Haematology
https://read.qxmd.com/read/31066029/type-2-diabetes-in-adults-with-sickle-cell-disease-can-we-dive-deeper-response-to-skinner-et-al
#11
LETTER
Jifang Zhou, Jin Han, Edith A Nutescu, William L Galanter, Surrey M Walton, Victor R Gordeuk, Santosh L Saraf, Gregory S Calip
No abstract text is available yet for this article.
May 8, 2019: British Journal of Haematology
https://read.qxmd.com/read/31066026/type-2-diabetes-in-adults-with-sickle-cell-disease-can-we-dive-deeper
#12
LETTER
Sarah Skinner, Elie Nader, Philippe Connes
No abstract text is available yet for this article.
May 8, 2019: British Journal of Haematology
https://read.qxmd.com/read/31066028/longitudinal-trend-analysis-of-serum-transferrin-receptor-1-level-in-a-cohort-of-patients-affected-by-non-transfusion-dependent-thalassaemia
#13
LETTER
Paolo Ricchi, Massimiliano Ammirabile, Silvia Costantini, Anna Spasiano, Patrizia Cinque, Biagio Gargiulo, Aldo Filosa
No abstract text is available yet for this article.
May 7, 2019: British Journal of Haematology
https://read.qxmd.com/read/31049940/role-of-mfhas1-in-regulating-hepcidin-expression-via-the-bmp-smad-and-mapk-erk1-2-signalling-pathways
#14
LETTER
Chutima Kumkhaek, Christian LaChance, Wulin Aerbajinai, Jianqiong Zhu, Griffin P Rodgers
No abstract text is available yet for this article.
May 2, 2019: British Journal of Haematology
https://read.qxmd.com/read/31044436/acute-myeloid-leukaemia-niche-regulates-response-to-l-asparaginase
#15
LETTER
Ilaria M Michelozzi, Valentina Granata, Giada De Ponti, Gaia Alberti, Chiara Tomasoni, Laura Antolini, Carlo Gambacorti-Passerini, Bernhard Gentner, Francesco Dazzi, Andrea Biondi, Tiziana Coliva, Carmelo Rizzari, Alice Pievani, Marta Serafini
Eradicating the malignant stem cell is the ultimate challenge in the treatment of leukaemia. Leukaemic stem cells (LSC) hijack the normal haemopoietic niche, where they are mainly protected from cytotoxic drugs. The anti-leukaemic effect of L-asparaginase (ASNase) has been extensively investigated in acute lymphoblastic leukaemia, but only partially in acute myeloid leukaemia (AML). We explored the susceptibility of AML-LSC to ASNase as well as the role of the two major cell types that constitute the bone marrow (BM) microenvironment, i...
May 1, 2019: British Journal of Haematology
https://read.qxmd.com/read/31044433/revisiting-fat-embolism-in-sickle-syndromes-diagnostic-and-emergency-therapeutic-measures
#16
LETTER
Dimitris A Tsitsikas, Jori E May, Radhika Gangaraju, Jibril Abukar, Roger J Amos, Marisa B Marques
No abstract text is available yet for this article.
May 1, 2019: British Journal of Haematology
https://read.qxmd.com/read/31044423/multicentre-retrospective-study-of-intravascular-large-b-cell-lymphoma-treated-at-academic-institutions-within-the-united-states
#17
Marcus Geer, Emily Roberts, Maryann Shango, Brian G Till, Stephen D Smith, Hashim Abbas, Brian T Hill, Jason Kaplan, Paul M Barr, Paolo Caimi, Deborah M Stephens, Emily Lin, Alex F Herrera, Evan Rosenbaum, Jennifer E Amengual, Philip S Boonstra, Sumana Devata, Ryan A Wilcox, Mark S Kaminski, Tycel J Phillips
Intravascular large B-cell lymphoma (IVLBCL) is a rare entity, with a generally aggressive course that may vary based on geographic presentation. While a United States (US) registry study showed relatively good outcomes with IVLBCL, clinicopathological and treatment data were unavailable. We performed a detailed retrospective review of cases identified at 8 US medical centres, to improve understanding of IVLBCL and inform management. We compiled data retrieved via an Institutional Review Board-approved review of IVLBCL cases identified from 1999 to 2015 at nine academic institutions across the US...
May 1, 2019: British Journal of Haematology
https://read.qxmd.com/read/31044418/could-haemochromatosis-hfe-gene-mutations-affect-response-to-iron-chelation-in-myelodysplastic-syndrome
#18
LETTER
Marko Lucijanic, Rajko Kusec
No abstract text is available yet for this article.
May 1, 2019: British Journal of Haematology
https://read.qxmd.com/read/31044417/post-translational-regulation-could-be-determine-functional-differences-between-set-alpha-and-beta-isoform-response-to-crist%C3%A3-bal-et-al
#19
LETTER
J Brice Weinberg, Danielle M Brander, Dale J Christensen, Daphne R Friedman
No abstract text is available yet for this article.
May 1, 2019: British Journal of Haematology
https://read.qxmd.com/read/31044416/could-haemochromatosis-hfe-gene-mutations-affect-response-to-iron-chelation-in-myelodysplastic-syndrome-response-to-lucijanic-and-kusec
#20
LETTER
Emiliano Fabiani, Lia Valentini, Daniela Cilloni, Maria T Voso
No abstract text is available yet for this article.
May 1, 2019: British Journal of Haematology
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