journal
https://read.qxmd.com/read/33838047/second-allogeneic-haematopoietic-cell-transplantation-using-hla-matched-unrelated-versus-t-cell-replete-haploidentical-donor-and-survival-in-relapsed-acute-myeloid-leukaemia
#1
Mohamed A Kharfan-Dabaja, Myriam Labopin, Eolia Brissot, Nicolaus Kroger, Jürgen Finke, Fabio Ciceri, Eric Deconinck, Didier Blaise, Patrice Chevallier, Martin Gramatzki, Arnold Ganser, Matthias Stelljes, Matthias Edinger, Bipin Savani, Annalisa Ruggeri, Jaime Sanz, Arnon Nagler, Mohamad Mohty
Optimal donor choice for a second allogeneic haematopoietic cell transplant (allo-HCT) in relapsed acute myeloid leukaemia (AML) remains unknown. We compared overall survival (OS) using registry data from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT) involving 455 adults who received a second allo-HCT from a human leucocyte antigen (HLA)-matched unrelated (MUD) (n = 320) or a haploidentical (n = 135) donor. Eligibility criteria required adults aged ≥18 years who received a second allo-HCT for treating AML relapse between 2005 and 2019...
April 10, 2021: British Journal of Haematology
https://read.qxmd.com/read/33837967/identification-of-cxcl12-abundant-reticular-cells-in-human-adult-bone-marrow
#2
Kazunari Aoki, Masako Kurashige, Michiko Ichii, Kei Higaki, Tatsuki Sugiyama, Takashi Kaito, Wataru Ando, Nobuhiko Sugano, Takashi Sakai, Hirohiko Shibayama, Akifumi Takaori-Kondo, Eiichi Morii, Yuzuru Kanakura, Takashi Nagasawa
A population of mesenchymal stem cells, termed CXC chemokine ligand (CXCL)12-abundant reticular (CAR) cells or leptin receptor-expressing cells, are the major cellular component of niches for haematopoietic stem cells (HSCs) in murine bone marrow. CAR cells are characterized by several salient features, including much higher expression of CXCL12, stem cell factor (SCF), forkhead box C1 (FOXC1) and early B-cell factor 3 (EBF3), which are essential for HSC maintenance, than other cells. However, the human counterpart of CAR cells has not been fully described...
April 10, 2021: British Journal of Haematology
https://read.qxmd.com/read/33837965/haematological-characteristics-and-spontaneous-haematological-recovery-in-pearson-syndrome
#3
LETTER
Ayami Yoshimi, Sarah C Grünert, Holger Cario, Aron Fisch, Ute Gross-Wieltsch, Kirsten Timmermann, Udo Kontny, Stephan Lobitz, Helen S Odenthal, Irene Schmid, Barbara Uetz, Tanja Höll, Agnès Rötig, Thomas Lücke, Arndt Borkhardt, Gabriele Strauß, Alexander Hohnecker, Markus Metzler, Daniela Karall, Charlotte M Niemeyer
No abstract text is available yet for this article.
April 10, 2021: British Journal of Haematology
https://read.qxmd.com/read/33829503/biomarkers-to-predict-infection-and-infection-related-complications-during-chemotherapy-induced-neutropenia-in-acute-myeloid-leukaemia-a-pilot-study
#4
LETTER
Annemarie van de Geer, Judith Zandstra, Michael W T Tanck, Efran Nur, Gerard van Mierlo, Ilse Jongerius, Robin van Bruggen, Sacha S Zeerleder, Taco W Kuijpers
No abstract text is available yet for this article.
April 8, 2021: British Journal of Haematology
https://read.qxmd.com/read/33829514/autologous-stem-cell-transplantation-in-the-age-of-andromeda
#5
Susan Bal, Morie A Gertz
No abstract text is available yet for this article.
April 7, 2021: British Journal of Haematology
https://read.qxmd.com/read/33822368/health-related-quality-of-life-in-patients-with-relapsed-or-refractory-multiple-myeloma-treatment-with-daratumumab-lenalidomide-and-dexamethasone-in-the-phase-3-pollux-trial
#6
Torben Plesner, Meletios A Dimopoulos, Albert Oriol, Jesus San-Miguel, Nizar J Bahlis, Neil Rabin, Kenshi Suzuki, Sung-Soo Yoon, Dina Ben-Yehuda, Gordon Cook, Hartmut Goldschmidt, Sebastian Grosicki, Xiang Qin, John Fastenau, Wendy Garvin, Robin Carson, Thomas Renaud, Katharine S Gries
In the phase 3 POLLUX trial, daratumumab in combination with lenalidomide and dexamethasone (D-Rd) significantly improved progression-free survival in patients with relapsed/refractory multiple myeloma (RRMM) compared with lenalidomide and dexamethasone (Rd) alone. Here, we present patient-reported outcomes (PROs) from POLLUX, assessed using the validated European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item (EORTC QLQ-C30) and the EuroQol 5-dimensional descriptive system (EQ-5D-5L) questionnaires...
April 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/33822358/thrombosis-in-immune-thrombocytopenia-current-status-and-future-perspectives
#7
REVIEW
Dawn Swan, Adrian Newland, Francesco Rodegheiro, Jecko Thachil
Immune thrombocytopenia (ITP) is an autoimmune disorder in which a combination of defective platelet production and enhanced clearance leads to thrombocytopenia. The primary aim for therapy in patients with this condition is the prevention of bleeding. However, more recently, increased rates of venous and arterial thrombotic events have been reported in ITP, even in the context of marked thrombocytopenia. In this review we discuss the epidemiology, aetiology and management of thrombotic events in these patients...
April 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/33822354/outcomes-of-methotrexate-associated-lymphoproliferative-disorders-in-rheumatoid-arthritis-patients-treated-with-disease-modifying-anti-rheumatic-drugs
#8
Takuya Harada, Hiromi Iwasaki, Tsuyoshi Muta, Shingo Urata, Aiko Sakamoto, Kentaro Kohno, Ken Takase, Tomoya Miyamura, Takuya Sawabe, Hideki Asaoku, Kensuke Oryoji, Tomoaki Fujisaki, Yasuo Mori, Goichi Yoshimoto, Masahiro Ayano, Hiroki Mitoma, Toshihiro Miyamoto, Hiroaki Niiro, Hidetaka Yamamoto, Yumi Oshiro, Hiroaki Miyoshi, Koichi Ohshima, Morishige Takeshita, Koichi Akashi, Koji Kato
Recently, the use of targeted synthetic or biological disease-modifying anti-rheumatic drugs (ts/bDMARDs) in addition to conventional synthetic (cs)DMARDs including methotrexate (MTX) for rheumatoid arthritis (RA) has increased. However, whether ts/bDMARDs are associated with the development and clinicopathological features of MTX-associated lymphoproliferative disorder (MTX-LPD) in patients with RA remains unknown. Therefore, we evaluated the clinical outcomes of 121 patients with MTX-LPD. Results showed that prior use of ts/bDMARDs was not associated with the different histopathological subtypes of MTX-LPD...
April 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/33821472/allogeneic-stem-cell-transplant-for-patients-with-myeloproliferative-neoplasms-in-blast-phase-improving-outcomes-in-the-recent-era
#9
LETTER
Mithun V Shah, Rima M Saliba, Ankur Verma, Stefan O Ciurea, Betul Oran, Amanda Olson, Prithviraj Bose, Qaiser Bashir, Lucia Masarova, Amin M Alousi, Samer Srour, Rohtesh S Mehta, Naval Daver, Naveen Pemmaraju, Srdan Verstovsek, Richard E Champlin, Uday R Popat
No abstract text is available yet for this article.
April 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/33818763/cutaneous-blastoid-mantle-cell-lymphoma
#10
Anne F P Overweel, Leo M Budel, Yorick Sandberg
No abstract text is available yet for this article.
April 5, 2021: British Journal of Haematology
https://read.qxmd.com/read/33792026/the-detection-of-circulating-plasma-cells-may-improve-the-revised-international-staging-system-r-iss-risk-stratification-of-patients-with-newly-diagnosed-multiple-myeloma
#11
Piero Galieni, Fosco Travaglini, Davide Vagnoni, Miriana Ruggieri, Patrizia Caraffa, Catia Bigazzi, Sadia Falcioni, Paola Picardi, Serena Mazzotta, Emanuela Troiani, Alessia Dalsass, Francesca Mestichelli, Mario Angelini, Elisa Camaioni, Denise Maravalle, Stefano Angelini, Valerio Pezzoni
The Revised International Staging System (R-ISS) stratifies patients affected by Multiple Myeloma (MM) into three distinct risk groups: R-ISS I [ISS Stage I, Standard-Risk cytogenetics and normal Lactase DeHydrogenase (LDH)], R-ISS III (ISS stage III and either high-risk cytogenetics or high LDH) and R-ISS II (any other characteristics). With the aim to verify whether the three R-ISS groups could be divided into subgroups with different prognostic factors based on the detection of Circulating Plasma Cells (CPCs) at diagnosis, in this retrospective analysis, we evaluated 161 patients with MM treated at our centre between 2005 and 2017...
April 1, 2021: British Journal of Haematology
https://read.qxmd.com/read/33783844/antibiotic-use-in-adults-during-sickle-cell-vaso-occlusive-crisis-is-it-time-for-a-controlled-trial
#12
LETTER
Tim Jang, George Mo, Connor Stewart, Ogechukwu Egini, Dibyendu Dutta, John Muthu, Seah H Lim
No abstract text is available yet for this article.
March 30, 2021: British Journal of Haematology
https://read.qxmd.com/read/33783838/mantle-cell-lymphoma-advances-in-molecular-biology-prognostication-and-treatment-approaches
#13
REVIEW
Elisabeth Silkenstedt, Kim Linton, Martin Dreyling
Mantle cell lymphoma (MCL) is clinically characterised by its heterogenous behaviour with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL with a very limited prognosis. A better understanding of the complex biology of MCL has already led to the approval of several innovative agents, expanding the landscape of MCL therapies and improving therapeutic options especially for refractory/relapsed (R/R) disease. Nevertheless, to further optimise MCL treatment, early identification of individual risk profile and risk-adapted, patient-tailored choice of therapeutic strategy needs to be prospectively incorporated into clinical patient management...
March 30, 2021: British Journal of Haematology
https://read.qxmd.com/read/33783834/advances-in-understanding-the-pathogenesis-of-hereditary-macrothrombocytopenia
#14
REVIEW
Janine Collins, William J Astle, Karyn Megy, Andrew D Mumford, Dragana Vuckovic
Low platelet count, or thrombocytopenia, is a common haematological abnormality, with a wide differential diagnosis, which may represent a clinically significant underlying pathology. Macrothrombocytopenia, the presence of large platelets in combination with thrombocytopenia, can be acquired or hereditary and indicative of a complex disorder. In this review, we discuss the interpretation of platelet count and volume measured by automated haematology analysers and highlight some important technical considerations relevant to the analysis of blood samples with macrothrombocytopenia...
March 30, 2021: British Journal of Haematology
https://read.qxmd.com/read/33782950/successful-tyrosine-kinase-inhibitor-discontinuation-outside-clinical-trials-data-from-the-population-based-swedish-chronic-myeloid-leukaemia-registry
#15
Hjalmar Flygt, Fredrik Sandin, Torsten Dahlén, Arta Dremaine, Anna Lübking, Berit Markevärn, Kristina Myhr-Eriksson, Karin Olsson, Ulla Olsson-Strömberg, Anders Själander, Stina Söderlund, Lovisa Wennström, Hans Wadenvik, Leif Stenke, Martin Höglund, Johan Richter
Clinical trials show that tyrosine kinase inhibitor (TKI) treatment can be discontinued in selected patients with chronic myeloid leukaemia (CML). Although updated CML guidelines support such procedure in clinical routine, data on TKI stopping outside clinical trials are limited. In this retrospective study utilising the Swedish CML registry, we examined TKI discontinuation in a population-based setting. Out of 584 patients diagnosed with chronic-phase CML (CML-CP) in 2007-2012, 548 had evaluable information on TKI discontinuation...
March 30, 2021: British Journal of Haematology
https://read.qxmd.com/read/33780008/similarities-in-coagulation-for-turophiles-and-clottologists
#16
LETTER
Jecko Thachil
No abstract text is available yet for this article.
March 29, 2021: British Journal of Haematology
https://read.qxmd.com/read/33779995/the-limited-role-of-comprehensive-staging-work-up-in-ocular-adnexal-extranodal-marginal-zone-lymphoma-of-mucosa-associated-lymphoid-tissue-type-maltoma-with-excellent-prognosis
#17
LETTER
Heejung Chae, Hyungwoo Cho, Ho-Seok Sa, Kyoung Won Kim, Eun Jin Chae, Jin-Sook Ryu, Chan-Sik Park, Jooryung Huh, Seongsoo Jang, Dok Hyun Yoon, Cheolwon Suh
No abstract text is available yet for this article.
March 29, 2021: British Journal of Haematology
https://read.qxmd.com/read/33772753/plasma-cell-dedifferentiation-in-refractory-multiple-myeloma
#18
Ahmadreza Arbab, Veronique Saada, Sophie Cotteret, Christophe Marzac, David Ghez
No abstract text is available yet for this article.
March 26, 2021: British Journal of Haematology
https://read.qxmd.com/read/33772751/imatinib-for-control-of-bullous-skin-lesions-in-a-child-with-familial-mastocytosis
#19
Joseph Kendall, Anna Martinez, Jack Bartram
No abstract text is available yet for this article.
March 26, 2021: British Journal of Haematology
https://read.qxmd.com/read/33765355/distinct-bone-marrow-immunophenotypic-features-define-the-splicing-factor-3b-subunit-1-sf3b1-mutant-myelodysplastic-syndromes-subtype
#20
Carolien Duetz, Theresia M Westers, Florentien E M In 't Hout, Eline M P Cremers, Canan Alhan, Bianca Venniker-Punt, Heleen A Visser-Wisselaar, Dana A Chitu, Aniek O de Graaf, Linda Smit, Joop H Jansen, Arjan A van de Loosdrecht
Splicing factor 3B subunit 1 (SF3B1) mutations define a distinct myelodysplastic syndromes (MDS) patient group with a relatively favourable disease course and high response rates to luspatercept. Few data are available on bone marrow phenotype beyond ring sideroblasts in this subgroup of patients with MDS. In the present study, we identified immunophenotypic erythroid, myelomonocyte and progenitor features associated with SF3B1 mutations. In addition, we illustrate that SF3B1-mutation type is associated with distinct immunophenotypic features, and show the impact of co-occurrence of a SF3B1 mutation and a deletion of chromosome 5q on bone marrow immunophenotype...
March 25, 2021: British Journal of Haematology
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