journal
https://read.qxmd.com/read/33427300/covid-19-associated-oxidative-damage-to-red-blood-cells
#1
Muhammad Khakwani, Claire Horgan, Joanne Ewing
No abstract text is available yet for this article.
January 11, 2021: British Journal of Haematology
https://read.qxmd.com/read/33426648/the-addition-of-bendamustine-to-brentuximab-vedotin-leads-to-improved-rates-of-complete-metabolic-remission-in-children-adolescents-and-young-adults-with-relapsed-and-refractory-classical-hodgkin-lymphoma-a-retrospective-single-centre-series
#2
LETTER
Annabel McMillan, Aideen T O'Neill, William Townsend, Jonathan Lambert, Andres Virchis, Raakhee Shah, Leon Menezes, Paul Humphries, Kirsten Von Both, Victoria Grandage, Ben Carpenter, Rachael Hough, Kirit M Ardeshna, Stephen Daw
No abstract text is available yet for this article.
January 10, 2021: British Journal of Haematology
https://read.qxmd.com/read/33421031/beeam-bendamustine-etoposide-cytarabine-melphalan-prior-to-autologous-stem-cell-transplant-for-chemosensitive-relapses-in-patients-with-follicular-lymphoma-a-prospective-multicentre-phase-ii-study-in-lymphoma-study-association-centres-%C3%A2
#3
LETTER
Hervé Ghesquières, Cécile Dalban, Emmanuelle Nicolas-Virelizier, Fabrice Jardin, Fabien Le Bras, Steven Le Gouill, Olivier Casasnovas, Séraphine Vizoso, Caroline Hernandez, Séverine Metzger, David Pérol, Guillaume Cartron
No abstract text is available yet for this article.
January 9, 2021: British Journal of Haematology
https://read.qxmd.com/read/33410523/eltrombopag-added-to-immunosuppression-for-children-with-treatment-na%C3%A3-ve-severe-aplastic-anaemia
#4
Emma M Groarke, Bhavisha A Patel, Fernanda Gutierrez-Rodrigues, Olga Rios, Jennifer Lotter, Daniela Baldoni, Annie St Pierre, Ruba Shalhoub, Colin O Wu, Danielle M Townsley, Neal S Young
Acquired severe aplastic anaemia (SAA) has an immune pathogenesis, and immunosuppressive therapy (IST) with anti-thymocyte globulin and cyclosporine is effective therapy. Eltrombopag (EPAG) added to standard IST was associated with higher overall and complete response rates in patients with treatment-naïve SAA compared to a historical IST cohort. We performed a paediatric subgroup analysis of this trial including all patients aged <18 years who received EPAG plus standard IST (n = 40 patients) compared to a historical cohort (n = 87) who received IST alone...
January 7, 2021: British Journal of Haematology
https://read.qxmd.com/read/33410504/impact-of-covid-19-on-red-blood-cell-rheology
#5
LETTER
Céline Renoux, Romain Fort, Elie Nader, Camille Boisson, Philippe Joly, Emeric Stauffer, Mélanie Robert, Sandrine Girard, Agnès Cibiel, Alexandra Gauthier, Philippe Connes
No abstract text is available yet for this article.
January 7, 2021: British Journal of Haematology
https://read.qxmd.com/read/33403687/next-generation-sequencing-improves-bcr-abl1-mutation-detection-in-philadelphia-chromosome-positive-acute-lymphoblastic-leukaemia
#6
Simona Soverini, Margherita Martelli, Luana Bavaro, Caterina De Benedittis, Cristina Papayannidis, Chiara Sartor, Federica Sorà, Francesco Albano, Sara Galimberti, Elisabetta Abruzzese, Mario Annunziata, Sabina Russo, Manuela Stulle, Annalisa Imovilli, Massimiliano Bonifacio, Elena Maino, Fabio Stagno, Claudia Maria Basilico, Erika Borlenghi, Claudio Fozza, Flavio Mignone, Roberta Minari, Stefania Stella, Michele Baccarani, Michele Cavo, Giovanni Martinelli
BCR-ABL1 kinase domain mutation testing in tyrosine kinase inhibitor (TKI)-resistant Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL) patients is routinely performed by Sanger sequencing (SS). Recently, next-generation sequencing (NGS)-based approaches have been developed that afford greater sensitivity and straightforward discrimination between compound and polyclonal mutations. We performed a study to compare the results of SS and NGS in a consecutive cohort of 171 Ph+ ALL patients...
January 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/33403676/insufficient-thrombopoietin-due-to-hepatic-dysmature-results-in-thrombocytopenia-in-small-for-gestational-age-rats
#7
LETTER
Satoru Takeshita, Hiroki Kakita, Kohki Toriuchi, Hiromasa Aoki, Hiroko Ueda, Akihiko Wakatsuki, Yasumasa Yamada, Mineyoshi Aoyama
No abstract text is available yet for this article.
January 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/33403663/melflufen-plus-dexamethasone-in-relapsed-refractory-multiple-myeloma-long-term-survival-follow-up-from-the-phase-ii-study-o-12-m1
#8
Sara Bringhen, Peter M Voorhees, Torben Plesner, Ulf-Henrik Mellqvist, Brandi Reeves, Pieter Sonneveld, Catriona Byrne, Eva Nordström, Johan Harmenberg, Jakob Obermüller, Paul G Richardson
An updated survival analysis was conducted for the Phase II study O-12-M1 of melphalan flufenamide (melflufen) plus dexamethasone in patients with relapsed/refractory multiple myeloma (RRMM) with two or more prior lines of therapy (including bortezomib and lenalidomide). Partial response or better was seen in 31%. After a 46-month median overall survival (OS) follow-up, melflufen plus dexamethasone had a median OS of 20·7 months (75th percentile OS, 47·5 months). The median time-to-next treatment for melflufen plus dexamethasone was 7·9 months...
January 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/33400262/pediatric-severe-aplastic-anaemia-treatment-where-to-start
#9
Timothy S Olson
No abstract text is available yet for this article.
January 5, 2021: British Journal of Haematology
https://read.qxmd.com/read/33399215/are-mushroom-shaped-erythrocytes-an-indicator-of-covid-19
#10
Delphine Gérard, Safa Ben Brahim, Jean François Lesesve, Julien Perrin
No abstract text is available yet for this article.
January 5, 2021: British Journal of Haematology
https://read.qxmd.com/read/33389748/changes-in-full-blood-count-parameters-with-age-and-sex-results-of-a-survey-of-almost-900-000-patient-samples-from-primary-care
#11
LETTER
Rupert Phillips, Henry Wood, Gary Weaving, Timothy Chevassut
No abstract text is available yet for this article.
January 3, 2021: British Journal of Haematology
https://read.qxmd.com/read/33386742/salmon-coloured-granules-in-residual-acute-myeloid-leukaemia-with-t-8-21-q22-q22-1-runx1-runx1t1
#12
Dong Chen, Weina Chen
No abstract text is available yet for this article.
January 2, 2021: British Journal of Haematology
https://read.qxmd.com/read/33386647/sars-cov-2-induced-remission-of-hodgkin-lymphoma
#13
Sarah Challenor, David Tucker
No abstract text is available yet for this article.
January 2, 2021: British Journal of Haematology
https://read.qxmd.com/read/33368165/daratumumab-monotherapy-for-relapsed-refractory-multiple-myeloma-focussed-on-clinical-trial-unfit-patients-and-subsequent-therapy
#14
Sung-Soo Park, Ja Min Byun, Sung-Soo Yoon, Kihyun Kim, Sung-Hoon Jung, Je-Jung Lee, Chang-Ki Min
Real-world outcomes of daratumumab monotherapy (DM) for relapsed/refractory multiple myeloma (RRMM) have remained unclear. We conducted a multicentre retrospective study of 107 patients receiving DM for RRMM. The cohort included 64 trial-unfit patients whose characteristics could not meet inclusion criteria in two previous clinical trials (GEN501 and SIRIUS). The overall response rate (ORR), and median first and second progression-free survival (PFS1 and PFS2) and overall survival were 42·1%, and 3·6, 8·1 and 11·9 months, respectively...
December 27, 2020: British Journal of Haematology
https://read.qxmd.com/read/33368157/incorporation-of-somatic-panels-for-the-detection-of-haematopoietic-transformation-in-children-and-young-adults-with-leukaemia-predisposition-syndromes-and-with-acquired-cytopenias
#15
Sharon Noy-Lotan, Tanya Krasnov, Orly Dgany, Marta Jeison, Asaf D Yanir, Oded Gilad, Helen Toledano, Shlomit Barzilai-Birenboim, Joanne Yacobovich, Shai Izraeli, Hannah Tamary, Orna Steinberg-Shemer
Detection of somatic mutations may help verify the diagnosis of myelodysplastic syndrome (MDS) in patients with persistent cytopenias or with MDS-predisposition syndromes, prior to the development of overt leukemia. However, the spectrum and consequences of acquired changes in paediatric patients have not been fully evaluated, and especially not in the context of an underlying syndrome. We incorporated a targeted next-generation-sequencing panel of 54 genes for the detection of somatic mutations in paediatric and young adult patients with inherited or acquired cytopenias...
December 27, 2020: British Journal of Haematology
https://read.qxmd.com/read/33368196/von-willebrand-factor-adamts13-axis-and-venous-thromboembolism-in-moderate-to-severe-covid-19-patients
#16
Maxime Delrue, Virginie Siguret, Marie Neuwirth, Bérangère Joly, Nicolas Beranger, Damien Sène, Benjamin G Chousterman, Sebastian Voicu, Philippe Bonnin, Bruno Mégarbane, Alain Stépanian
No abstract text is available yet for this article.
December 24, 2020: British Journal of Haematology
https://read.qxmd.com/read/33368182/microrna-2355-5p-regulates-%C3%AE-globin-expression-in-human-erythroid-cells-by-inhibiting-klf6
#17
Yi Cheng, Xuan Shang, Diyu Chen, Dejian Pang, Cunyou Zhao, Xiangmin Xu
Krüppel-like factors (KLFs) are a highly conserved family of transcription factors. We analysed expression profile data of KLFs and identified KLF6 as a new potential regulator of erythropoiesis. Knocking down the expression of KLF6 significantly raised γ-globin mRNA and protein levels in the erythroid cell line HUDEP-2 and haematopoietic progenitor (CD34+ ) cells. We found that overexpression of microRNA (miR)-2355-5p in HUDEP-2 and CD34+ cells correlated with increased γ-globin synthesis by suppressing expression of KLF6...
December 24, 2020: British Journal of Haematology
https://read.qxmd.com/read/33368155/tki-dose-reduction-can-effectively-maintain-major-molecular-remission-in-patients-with-chronic-myeloid-leukaemia
#18
Simone Claudiani, Jane F Apperley, Richard Szydlo, Afzal Khan, George Nesr, Chloe Hayden, Andrew J Innes, Kathy Dominy, Pierre Foskett, Letizia Foroni, Jamshid Khorashad, Dragana Milojkovic
Targeted therapy for chronic myeloid leukaemia (CML) has allowed for a near-normal patient life-expectancy; however, quality of life and aggravation of existing co-morbidities have posed new treatment challenges. In clinical practice, TKI dose reduction occurs frequently, often on multiple occasions, because of intolerance. We conducted a retrospective 'real-world practice' review of 246 patients receiving lower than standard dose (LD) TKI after the achievement of major molecular response (MR3), because of intolerable adverse events...
December 24, 2020: British Journal of Haematology
https://read.qxmd.com/read/33368172/the-revised-guidelines-for-the-diagnosis-and-management-of-hairy-cell-leukaemia-and-the-hairy-cell-leukaemia-variant
#19
Xavier Troussard, Michael R Grever
No abstract text is available yet for this article.
December 23, 2020: British Journal of Haematology
https://read.qxmd.com/read/33350457/longitudinal-changes-in-red-blood-cell-distribution-width-decades-after-radiation-exposure-in-atomic-bomb-survivors
#20
Kengo Yoshida, Munechika Misumi, Yoichiro Kusunoki, Michiko Yamada
Red blood cell distribution width (RDW), which generally increases with age, is a risk marker for morbidity and mortality in various diseases. We investigated the association between elevated RDW and prior radiation exposure by examining longitudinal RDW changes in 4204 atomic-bomb survivors over 15 years. A positive association was found between RDW and radiation dose, wherein RDW increased by 0·18%/Gy. This radiation-associated effect increased as the participants aged. Elevated RDW was also associated with higher all-cause mortality...
December 22, 2020: British Journal of Haematology
journal
journal
20057
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"