journal
https://read.qxmd.com/read/34291829/multiregional-sequencing-and-circulating-tumour-dna-analysis-provide-complementary-approaches-for-comprehensive-disease-profiling-of-small-lymphocytic-lymphoma
#1
Riccardo Moia, Chiara Favini, Valentina Ferri, Gabriela Forestieri, Lodovico Terzi Di Bergamo, Mattia Schipani, Sruthi Sagiraju, Annalisa Andorno, Silvia Rasi, Ramesh Adhinaveni, Donatella Talotta, Wael Al Essa, Lorenzo De Paoli, Gloria Margiotta Casaluci, Andrea Patriarca, Renzo L Boldorini, Davide Rossi, Gianluca Gaidano
We aimed at molecularly dissecting the anatomical heterogeneity of small lymphocytic lymphoma (SLL), by analysing a cohort of 12 patients for whom paired DNA from a lymph node biopsy and circulating cells, as well as plasma-circulating tumour DNA (ctDNA) was available. Notably, the analyses of the lymph node biopsy and of circulating cells complement each other since a fraction of mutations (20·4% and 36·4%, respectively) are unique to each compartment. Plasma ctDNA identified two additional unique mutations...
July 22, 2021: British Journal of Haematology
https://read.qxmd.com/read/34291449/hydroxycarbamide-treatment-reduces-transcranial-doppler-velocity-in-the-absence-of-transfusion-support-in-children-with-sickle-cell-anaemia-elevated-transcranial-doppler-velocity-and-cerebral-vasculopathy-the-extend-trial
#2
Angela Rankine-Mullings, Marvin Reid, Deanne Soares, Carolyn Taylor-Bryan, Margaret Wisdom-Phipps, Karen Aldred, Teresa Latham, William H Schultz, Jennifer Knight-Madden, Asha Badaloo, Adam Lane, Robert J Adams, Russell E Ware
EXpanding Treatment for Existing Neurological Disease (EXTEND) investigated whether hydroxycarbamide lowers transcranial Doppler (TCD) velocities in Jamaican children with sickle cell anaemia (SCA) and elevated TCD velocity with or without previous stroke. Forty-three children (age 2-17 years) with baseline maximum time-averaged mean velocity (TAMV) ≥ 170 cm/s were stratified into three risk categories based on treatment status and stroke history: Group 1 (no history of stroke, on hydroxycarbamide, n = 12); and Groups 2 (no stroke, no hydroxycarbamide, n = 21) and 3 (previous stroke, no hydroxycarbamide, n = 10)...
July 22, 2021: British Journal of Haematology
https://read.qxmd.com/read/34272731/ebv-positive-hiv-associated-diffuse-large-b-cell-lymphomas-are-characterized-by-jak-stat-stat3-pathway-mutations-and-unique-clinicopathologic-features
#3
Jennifer R Chapman, Alyssa C Bouska, Weiwei Zhang, Juan Pablo Alderuccio, Izidore S Lossos, Lisa M Rimsza, Alanna Maguire, Shuhua Yi, Wing C Chan, Francisco Vega, Joo Y Song
Even in the era of highly active combination antiretroviral therapy (cART), patients with HIV have a disproportionate risk of developing aggressive lymphomas that are frequently Epstein-Barr virus (EBV)-related. Here, we investigate HIV-associated diffuse large B-cell lymphoma (HIV-DLBCL) and compare EBV-positive and EBV-negative cases. HIV-DLBCL were identified from two academic medical centres and characterised by immunohistochemistry, EBV status, fluorescence in situ hybridisation, cell of origin determination by gene expression profiling, and targeted deep sequencing using a custom mutation panel of 334 genes...
July 17, 2021: British Journal of Haematology
https://read.qxmd.com/read/34272726/hydroxyurea-treatment-and-neurocognitive-functioning-in-sickle-cell-disease-from-school-age-to-young-adulthood
#4
Andrew M Heitzer, Jennifer Longoria, Victoria Okhomina, Winfred C Wang, Darcy Raches, Brian Potter, Lisa M Jacola, Jerlym Porter, Jane E Schreiber, Allison A King, Guolian Kang, Jane S Hankins
Neurocognitive impairment is common in sickle cell disease (SCD) and is associated with significant functional limitations. In a cross-sectional analysis, we examined the association between hydroxyurea (HU) treatment and neurocognitive functioning from school-age to young adulthood in individuals with SCD. A total of 215 patients with HbSS/HbSβ0 -thalassaemia (71% HU treated) and 149 patients with HbSC/HbSβ+ -thalassaemia (20% HU treated) completed neurocognitive measures at one of four developmental stages: school-age (age 8-9 years), early adolescence (age 12-13 years), late adolescence (age 16-17 years) and young adulthood (ages 19-24 years)...
July 16, 2021: British Journal of Haematology
https://read.qxmd.com/read/34272724/covid-19-elicits-an-impaired-antibody-response-against-sars-cov-2-in-patients-with-haematological-malignancies
#5
Francesco Passamonti, Alessandra Romano, Marco Salvini, Francesco Merli, Matteo G Della Porta, Riccardo Bruna, Elisa Coviello, Ilaria Romano, Roberto Cairoli, Roberto Lemoli, Francesca Farina, Adriano Venditti, Alessandro Busca, Marco Ladetto, Massimo Massaia, Antonio Pinto, Luca Arcaini, Agostino Tafuri, Francesco Marchesi, Nicola Fracchiolla, Monica Bocchia, Daniele Armiento, Anna Candoni, Mauro Krampera, Mario Luppi, Valeria Cardinali, Sara Galimberti, Chiara Cattaneo, Elettra Ortu La Barbera, Roberto Mina, Francesco Lanza, Giuseppe Visani, Pellegrino Musto, Luigi Petrucci, Francesco Zaja, Paolo A Grossi, Lorenza Bertù, Livio Pagano, Paolo Corradini
COVID-19 is associated with high mortality in patients with haematological malignancies (HM) and rate of seroconversion is unknown. The ITA-HEMA-COV project (NCT04352556) investigated patterns of seroconversion for SARS-CoV-2 IgG in patients with HMs. A total of 237 patients, SARS-CoV-2 PCR-positive with at least one SARS-CoV-2 IgG test performed during their care, entered the analysis. Among these, 62 (26·2%) had myeloid, 121 (51·1%) lymphoid and 54 (22·8%) plasma cell neoplasms. Overall, 69% of patients (164 of 237) had detectable IgG SARS-CoV-2 serum antibodies...
July 16, 2021: British Journal of Haematology
https://read.qxmd.com/read/34268729/biomarkers-of-clinical-severity-in-treated-and-untreated-sickle-cell-disease-a-comparison-by-genotypes-of-a-single-center-cohort-and-african-americans-in-the-nhanes-study
#6
Franklin Njoku, Xu Zhang, Binal N Shah, Roberto F Machado, Jin Han, Santosh L Saraf, Victor R Gordeuk
Haemolysis and vaso-occlusion underlie multi-organ system complications in sickle cell disease (SCD). We assessed real-world biomarkers in University of Illinois adult SCD patients, categorised as severe (HbSS/Sβ0 -thalassaemia; n = 342) or mild (HbSC/Sβ+ -thalassaemia; n = 100) genotypes and stratified according to treatment. African-American controls from the National Health and Nutrition Examination Survey (NHANES) were matched with each genotype category. Most measures of haemolysis, anaemia, inflammation and function of kidneys, liver and lungs differed markedly in untreated severe genotype patients compared to NHANES controls...
July 15, 2021: British Journal of Haematology
https://read.qxmd.com/read/34263940/qualitative-study-to-support-the-content-validity-of-the-immune-thrombocytopenia-itp-life-quality-index-ilqi
#7
Nichola Cooper, Adam Cuker, Nicola Bonner, Waleed Ghanima, Drew Provan, Mervyn Morgan, Barbara Taylor, Denise D'Alessio, Donald Arnold, Ricardo Viana
Immune thrombocytopenia (ITP) is an acquired immune-mediated disorder. Bleeding is the primary symptom that presents in varying severities. ITP has a negative impact on health-related quality of life (HRQoL). The ITP Life Quality Index (ILQI) was developed as a 10-item patient-reported outcome measure to assess impact on HRQoL in ITP. The objective of the present study was to confirm the content validity of the ILQI with a qualitative interview study in the UK involving 15 adult participants with ITP. Combined concept elicitation (CE) and cognitive debriefing (CD) interviews were conducted to explore the symptoms and impacts associated with ITP and confirm content validity of the draft ILQI...
July 15, 2021: British Journal of Haematology
https://read.qxmd.com/read/34263927/hemophagocytic-lymphohistiocytosis-like-toxicity-carhlh-after-cd19-specific-car-t-cell-therapy
#8
Melissa R Hines, Camille Keenan, Gabriela Maron Alfaro, Cheng Cheng, Yinmei Zhou, Akshay Sharma, Caitlin Hurley, Kim E Nichols, Stephen Gottschalk, Brandon M Triplett, Aimee C Talleur
Chimeric antigen receptor T-cell (CAR T-cell) therapy is associated with significant toxicities secondary to immune activation, including a rare but increasingly recognised severe toxicity resembling haemophagocytic lymphohistiocytosis (carHLH). We report the development of carHLH in 14·8% of paediatric patients and young adults treated with CD19-specific CAR T-cell therapy with carHLH, occurring most commonly in those with high disease burden. The diagnosis and treatment of carHLH required a high index of suspicion and included multidrug immunomodulation with variable response to therapies...
July 15, 2021: British Journal of Haematology
https://read.qxmd.com/read/34263922/fluid-overload-due-to-intravenous-fluid-therapy-for-vaso-occlusive-crisis-in-sickle-cell-disease-incidence-and-risk-factors
#9
Aafke E Gaartman, Ajab K Sayedi, Jorn J Gerritsma, Tim R de Back, Charlotte F van Tuijn, Man Wai Tang, Harriët Heijboer, Koen de Heer, Bart J Biemond, Erfan Nur
Intravenous fluid therapy (IV-FT) is routinely used in the treatment of vaso-occlusive crises (VOCs), as dehydration possibly promotes and sustains erythrocyte sickling. Patients with sickle cell disease (SCD) are at risk of developing diastolic dysfunction and fluid overload due to IV-FT. However, data on the adverse effects of IV-FT for VOC is sparse. We aimed to evaluate the incidence and risk factors of fluid overload due to IV-FT in patients with SCD. Consecutive hospitalisations for VOC treated with IV-FT between September 2016 and September 2018 were retrospectively analysed...
July 15, 2021: British Journal of Haematology
https://read.qxmd.com/read/34258755/characteristics-of-genetic-alterations-of-peripheral-t-cell-lymphoma-in-childhood-including-identification-of-novel-fusion-genes-the-japan-children-s-cancer-group-jccg
#10
Kentaro Ohki, Nobutaka Kiyokawa, Satoru Watanabe, Hideto Iwafuchi, Astuko Nakazawa, Keisuke Ishiwata, Hiroko Ogata-Kawata, Kazuhiko Nakabayashi, Kohji Okamura, Fumiko Tanaka, Reiji Fukano, Kenichiro Hata, Tetsuya Mori, Akiko Moriya Saito, Yasuhide Hayashi, Takashi Taga, Masahiro Sekimizu, Ryoji Kobayashi
Peripheral T-cell lymphoma (PTCL) is a group of heterogeneous non-Hodgkin lymphomas showing a mature T-cell or natural killer cell phenotype, but its molecular abnormalities in paediatric patients remain unclear. By employing next-generation sequencing and multiplex ligation-dependent probe amplification of tumour samples from 26 patients, we identified somatic alterations in paediatric PTCL including Epstein-Barr virus (EBV)-negative (EBV- ) and EBV-positive (EBV+ ) patients. As recurrent mutational targets for PTCL, we identified several previously unreported genes, including TNS1, ZFHX3, LRP2, NCOA2 and HOXA1, as well as genes previously reported in adult patients, e...
July 13, 2021: British Journal of Haematology
https://read.qxmd.com/read/34258754/the-impact-of-clonal-diversity-and-mosaicism-on-haematopoietic-function-in-fanconi-anaemia
#11
REVIEW
Andrew D Hughes, Peter Kurre
Recent advances have facilitated studies of the clonal architecture of the aging haematopoietic system, and provided clues to the mechanisms underlying the origins of hematopoietic malignancy. Much less is known about the clonal composition of haematopoiesis and its impact in bone marrow failure (BMF) disorders, including Fanconi anaemia (FA). Understanding clonality in FA is likely to inform both the marked predisposition to cancer and the rapid erosion of regenerative reserve seen with this disease. This may also hold broader lessons for haematopoietic stem cell biology in other diseases with a clonal restriction...
July 13, 2021: British Journal of Haematology
https://read.qxmd.com/read/34254314/a-novel-hnrnpc-rara-fusion-in-acute-promyelocytic-leukaemia-lacking-pml-rara-rearrangement-sensitive-to-venetoclax-based-therapy
#12
LETTER
Meng Liu, Xiujie Zhao, Wenjue Pan, Zijun Qian, Mengbao Du, Li-Mengmeng Wang, He Huang, Haowen Xiao
No abstract text is available yet for this article.
July 13, 2021: British Journal of Haematology
https://read.qxmd.com/read/34254289/ruxolitinib-resistance-or-intolerance-in-steroid-refractory-acute-graft-versus-host-disease-a-real-world-outcomes-analysis
#13
Sameem Abedin, Nahid Rashid, Mark Schroeder, Rizwan Romee, Mary Nauffal, Muhamad Alhaj Moustafa, Mohamed A Kharfan-Dabaja, Jeanne Palmer, William Hogan, Mehrdad Hefazi, Samantha Larson, Shernan Holtan, Zachariah DeFilipp, Reena Jayani, Bhagirathbhai Dholaria, Joseph Pidala, Farhad Khimani, Michael R Grunwald, Candace Butler, Mehdi Hamadani
Ruxolitinib for steroid-refractory acute graft-versus-host disease (SR-aGVHD) results in resistance or intolerance in 1/5 of patients. Outcomes of such patients are undefined. We identified these patients in a multicentre review and reported outcomes. Ruxolitinib-resistant aGVHD was identified in 48/307 patients. Among patients receiving additional therapy, the overall response rate to next therapy was 36%. Median survival was 21 days. Ruxolitinib intolerance led to treatment discontinuation in 16/307 patients...
July 12, 2021: British Journal of Haematology
https://read.qxmd.com/read/34254287/blinatumomab-for-paediatric-mixed-phenotype-acute-leukaemia
#14
LETTER
Jack Bartram, Milena Balasch-Carulla, Shashank Bhojaraja, Stuart Adams, Danny Cheng, Sarah Inglott, Nimish Kulkarni, Arunthethy Mahendrayogam, Olya O'Connor, Vesna Pavasovic, Ajay Vora
No abstract text is available yet for this article.
July 12, 2021: British Journal of Haematology
https://read.qxmd.com/read/34247384/immature-platelets-in-covid-19-infection
#15
Robert W Maitta
No abstract text is available yet for this article.
July 11, 2021: British Journal of Haematology
https://read.qxmd.com/read/34244996/high-risk-transcriptional-profiles-in-multiple-myeloma-are-an-acquired-feature-that-can-occur-in-any-subtype-and-more-frequently-with-each-subsequent-relapse
#16
LETTER
Eileen M Boyle, Adam Rosenthal, Yan Wang, Philip Farmer, Michael Rutherford, Cody Ashby, Michael Bauer, Sarah K Johnson, Christopher P Wardell, Antje Hoering, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Bart Barlogie, Faith E Davies, Brian A Walker, Frits van Rhee, Gareth J Morgan
No abstract text is available yet for this article.
July 9, 2021: British Journal of Haematology
https://read.qxmd.com/read/34231198/knowledge-gaps-in-reproductive-and-sexual-health-in-girls-and-women-with-sickle-cell-disease
#17
REVIEW
Lydia H Pecker, Deva Sharma, Alecia Nero, Michael J Paidas, Russell E Ware, Andra H James, Kim Smith-Whitley
There is an immediate need to address long-standing questions about the reproductive health of girls and women with sickle cell disease (SCD). There are many SCD-related reproductive risks and uncertainties across girls' and women's reproductive life span, with particularly outstanding concerns about menstruation, contraception, fertility and pregnancy. Extant literature addressing women's reproductive health topics is mostly descriptive; there are few high-quality interventional studies. In 2020, the Centers for Disease Control and Prevention and the Foundation for Women and Girls with Blood Disorders convened an expert panel to assess the knowledge gaps in women's reproductive health in SCD...
July 7, 2021: British Journal of Haematology
https://read.qxmd.com/read/34231209/hydroxyurea-therapy-decreases-coagulation-and-endothelial-activation-in-sickle-cell-disease-a-longitudinal-study
#18
LETTER
Laila Elsherif, Lara C Scott, David Wichlan, Susan K Jones, Joacy G Mathias, Jessica H Shen, Matthew P Smeltzer, Kenneth I Ataga
No abstract text is available yet for this article.
July 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/34231202/direct-oral-anticoagulant-use-in-patients-with-antiphospholipid-syndrome-and-unprovoked-venous-thromboembolism-a-single-centre-experience
#19
LETTER
Andrew J Doyle, Beverley J Hunt, Anicee Danaee, Gavin Ling, Michael J Desborough, Pulin Luo, Karen A Breen
No abstract text is available yet for this article.
July 6, 2021: British Journal of Haematology
https://read.qxmd.com/read/34231199/doing-less-accomplishing-more-for-childhood-acute-lymphoblastic-leukaemia-all
#20
Allen E J Yeoh, Bernice L-Z Oh, Hany Ariffin
No abstract text is available yet for this article.
July 6, 2021: British Journal of Haematology
journal
journal
20057
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"