journal

British Journal of Haematology

journal
https://read.qxmd.com/read/32232989/outcomes-of-older-patients-with-primary-central-nervous-system-lymphoma-treated-in-routine-clinical-practice-in-the-uk-methotrexate-dose-intensity-correlates-with-response-and-survival
#1
Nicolás Martinez-Calle, Edward Poynton, Alia Alchawaf, Shireen Kassam, Matthew Horan, Mark Rafferty, Phillipa Kelsey, Gemma Scott, Dominic J Culligan, Hannah Buckley, Yeong Y Lim, Loretta Ngu, Rory McCulloch, Clare Rowntree, Josh Wright, Pamela McKay, Samih Fourali, Toby A Eyre, Jeffrey Smith, Wendy Osborne, Deborah Yallop, Kim Linton, Christopher P Fox, Kate Cwynarski
Data on older patients with primary central nervous system lymphoma (PCNSL) are scarce. Comorbidities and performance status frequently compromise outcomes in this group. Medical records for consecutive patients ≥65 years (n = 244) with PCNSL diagnosed 2012-2017 from 14 UK centres were retrospectively reviewed. Of these 192 patients received methotrexate (MTX)-based treatment. Patients were categorised based on clinician's treatment choice into 'palliative' (n = 52), 'less intensive: MTX ± rituximab ± alkylators' (n = 74) and 'intensive: MTX/cytarabine combinations' (n = 118) groups...
March 31, 2020: British Journal of Haematology
https://read.qxmd.com/read/32232981/analysis-of-saliva-samples-and-cluster-of-differentiation-3-cd3-lymphocytes-as-a-source-of-germline-dna-in-myeloproliferative-neoplasms
#2
LETTER
Nieves Garcia-Gisbert, Laura Camacho, Lierni Fernández-Ibarrondo, Concepcion Fernández-Rodriguez, Raquel Longarón, Joan Gibert, Anna Angona, Marcio Andrade-Campos, Antonio Salar, Carlos Besses, Beatriz Bellosillo
No abstract text is available yet for this article.
March 31, 2020: British Journal of Haematology
https://read.qxmd.com/read/32232846/efficacy-and-safety-of-humanized-anti-cd19-car-t-therapy-following-intensive-lymphodepleting-chemotherapy-for-refractory-relapsed-b-acute-lymphoblastic-leukaemia
#3
Jia Wang, Nan Mou, Zhenxing Yang, Qing Li, Yanyu Jiang, Juanxia Meng, Xuxiang Liu, Qi Deng
We studied the efficacy and safety of humanized CAR-T therapy following intensive chemotherapy for refractory/relapsed (R/R) acute lymphoblastic leukaemia (B-ALL). Twenty-three patients with R/R B-ALL were pretreated with intensive chemotherapy (fludarabine combined with medium-dose cytarabine) 12 days before CAR-T therapy. Adverse events (AEs), curative effects, infection indicators and cytokine release syndrome (CRS) were monitored. Each of the 23 patients received a dose of 1·0 × 106 cells/kg CAR-T cell infusion on day 0...
March 31, 2020: British Journal of Haematology
https://read.qxmd.com/read/32232851/novel-exomic-rare-variants-associated-with-venous-thrombosis
#4
Hiroshi Deguchi, Meenal Shukla, Mohammed Hayat, Ali Torkamani, Darlene J Elias, John H Griffin
Exomic rare variant polymorphisms (c. 300 000) were analysed in the Scripps Venous Thrombosis (VTE) registry (subjects aged <55 years). Besides coagulation factor V (F5) single nucleotide polymorphisms (SNPs), family with sequence similarity 134, member B (FAM134B; rs78314670, Arg127Cys) and myosin heavy chain 8 (MYH8; rs111567318, Glu1838Ala) SNPs were associated with recurrent VTE (n = 34 cases) (false discovery rate-adjusted P < 0·05). FAM134B (rs78314670) was associated with low plasma levels of anticoagulant glucosylceramide...
March 30, 2020: British Journal of Haematology
https://read.qxmd.com/read/32232850/the-anti-mitotic-agents-ptc-028-and-ptc596-display-potent-activity-in-pre-clinical-models-of-multiple-myeloma-but-challenge-the-role-of-bmi-1-as-an-essential-tumour-gene
#5
Arnold Bolomsky, Joséphine Muller, Kathrin Stangelberger, Margaux Lejeune, Elodie Duray, Helene Breid, Louise Vrancken, Christina Pfeiffer, Wolfgang Hübl, Martin Willheim, Marla Weetall, Art Branstrom, Niklas Zojer, Jo Caers, Heinz Ludwig
Future progress in the treatment of multiple myeloma (MM) requires both the characterisation of key drivers of the disease and novel, innovative approaches to tackle these vulnerabilities. The present study focussed on the pre-clinical evaluation of a novel drug class, BMI-1 modulators, in MM. We demonstrate potent activity of PTC-028 and PTC596 in a comprehensive set of in vitro and in vivo models, including models of drug resistance and stromal support. Treatment of MM cells with PTC-028 and PTC596 downregulated BMI-1 protein levels, which was found to correlate with drug activity...
March 30, 2020: British Journal of Haematology
https://read.qxmd.com/read/32232834/increased-iron-stores-influence-glucose-metabolism-in-sickle-cell-anaemia
#6
LETTER
Binal N Shah, Taif O Hassan, Xu Zhang, Donald A McClain, Victor R Gordeuk
No abstract text is available yet for this article.
March 30, 2020: British Journal of Haematology
https://read.qxmd.com/read/32227648/target-a-survey-of-real-world-management-of-chronic-myeloid-leukaemia-across-33-countries
#7
Anna Turkina, Jianxiang Wang, Vikram Mathews, Guray Saydam, Chul Won Jung, Hani Hassan Al Hashmi, Mohamed Yassin, Solenn Le Clanche, Darko Miljkovic, Cassandra Slader, Timothy P Hughes
Despite the availability of guidelines for the management of chronic myeloid leukaemia (CML), various issues may prevent their successful implementation. The TARGET survey examined real-world management of CML patients compared with international recommendations. This online survey was completed in 2017. Results were discussed by a Steering Committee (SC) of eight international haematologists, challenges were identified and practical solutions developed. Of the 1008 haematologists invited (33 countries), 614 completed the survey...
March 30, 2020: British Journal of Haematology
https://read.qxmd.com/read/32227335/gains-of-epor-and-erg-genes-in-adult-erythroleukaemia
#8
José Adélaïde, Nathalie Cervera, Arnaud Guille, Anne Murati, Max Chaffanet, Marie-Joëlle Mozziconacci, Norbert Vey, Daniel Birnbaum, Véronique Gelsi-Boyer
No abstract text is available yet for this article.
March 29, 2020: British Journal of Haematology
https://read.qxmd.com/read/32220069/at-three-years-patients-with-acute-lymphoblastic-leukaemia-are-still-at-risk-for-relapse-results-of-the-international-mrc-ukallxii-ecog-e2993-trial
#9
Chezi Ganzel, Xin V Wang, Jacob M Rowe, Susan M Richards, Georgina Buck, David I Marks, Mark R Litzow, Elisabeth M Paietta, Letizia Foroni, Selina M Luger, Cheryl L Willman, Charles G Mullighan, Kathryn G Roberts, Peter H Wiernik, Dan Douer, Hillard M Lazarus, Martin S Tallman, Anthony H Goldstone
Late relapse [>3 years from complete remission (CR)] in acute lymphoblastic leukaemia (ALL), is unusual. Data from the MRC UKALLXII/ECOG E2993 trial are presented to evaluate the incidence and characteristics of late relapse in adult ALL. Of 1,909 patients, 1,752 (92%) achieved CR and among these 757 (43·2%) relapsed; 691 (91·3%) within three years and 66 (8·7%) beyond. Among these 66 patients, median time to relapse was 47 (37-144) months. Relapse beyond three years occurred in 3·8% of all who achieved CR...
March 27, 2020: British Journal of Haematology
https://read.qxmd.com/read/32220013/serum-markers-alone-can-define-high-risk-smouldering-multiple-myeloma-new-insights-from-the-czech-myeloma-group-model
#10
Rasmus Sørrig
No abstract text is available yet for this article.
March 27, 2020: British Journal of Haematology
https://read.qxmd.com/read/32219863/platelet-phagocytosis-by-lymphocytes
#11
Geng Wang, Fei Wang, Chunmei Huang, Xin Wang, Wei Wu
No abstract text is available yet for this article.
March 26, 2020: British Journal of Haematology
https://read.qxmd.com/read/32207157/incidence-of-hip-and-knee-osteonecrosis-and-their-associations-with-bone-mineral-density-in-children-with-acute-lymphoblastic-leukaemia
#12
LETTER
Hiroto Inaba, Xueyuan Cao, Jennifer Y Chang, Seth E Karol, John C Panetta, Kirsten K Ness, Cheng Cheng, Ching-Hon Pui, Mary V Relling, Sue C Kaste
No abstract text is available yet for this article.
March 24, 2020: British Journal of Haematology
https://read.qxmd.com/read/32207154/catheter-associated-thromboses-in-patients-with-sickle-cell-anaemia-and-dual-lumen-vortex-apheresis-ports-are-common-and-can-be-clinically-asymptomatic
#13
LETTER
John N Brewin, Maeve P Crowley, Rachel Kesse-Adu, Sara Stuart-Smith, Moji Awogbade, Jo Howard
No abstract text is available yet for this article.
March 24, 2020: British Journal of Haematology
https://read.qxmd.com/read/32207147/improving-outcomes-for-non-hodgkin-lymphoma-in-sub-saharan-africa-where-to-start
#14
Matthew S Painschab, Katherine D Westmoreland, Tamiwe Tomoka
No abstract text is available yet for this article.
March 24, 2020: British Journal of Haematology
https://read.qxmd.com/read/32207144/distinct-bone-marrow-morphologic-features-discriminate-myelodysplastic-syndromes-patients-with-and-without-an-early-platelet-response-to-decitabine
#15
LETTER
Annette M May, Julia Stomper, Tina E Joeckel, Peter Bronsert, Pierre W Wijermans, Martin Werner, Michael Lübbert
No abstract text is available yet for this article.
March 24, 2020: British Journal of Haematology
https://read.qxmd.com/read/32201943/product-type-and-the-risk-of-inhibitor-development-in-nonsevere-haemophilia-a-patients-a-case-control-study
#16
Alice S van Velzen, Corien L Eckhardt, Marjolein Peters, Johannes Oldenburg, Marjon Cnossen, Ri Liesner, Massimo Morfini, Giancarlo Castaman, Simon McRae, Johanna G van der Bom, Karin Fijnvandraat
Inhibitor development is a major complication of treatment with factor VIII concentrates in nonsevere haemophilia A. It has been suggested that plasma-derived factor VIII (FVIII) concentrates elicit fewer inhibitors than recombinant FVIII concentrates, but studies in severe haemophilia A patients have shown conflicting results. We designed a case-control study to investigate the clinical and genetic risk factors for inhibitor development in nonsevere haemophilia A patients. We investigated whether the type of FVIII concentrate was associated with inhibitor development in nonsevere haemophilia A patients...
March 22, 2020: British Journal of Haematology
https://read.qxmd.com/read/32200565/amyloid-purpura-of-the-breasts-in-a-patient-with-systemic-al-amyloidosis
#17
Chakra P Chaulagain
No abstract text is available yet for this article.
March 22, 2020: British Journal of Haematology
https://read.qxmd.com/read/32196650/myelofibrosis-biology-and-contemporary-management
#18
REVIEW
Naseema Gangat, Ayalew Tefferi
Myelofibrosis is an enigmatic myeloproliferative neoplasm, despite noteworthy strides in understanding its genetic underpinnings. Driver mutations involving JAK2, CALR or MPL in 90% of patients mediate constitutive JAK-STAT signaling which, in concert with epigenetic alterations (ASXL1, DNMT3A, SRSF2, EZH2, IDH1/2 mutations), play a fundamental role in disease pathogenesis. Aberrant immature megakaryocytes are a quintessential feature, exhibiting reduced GATA1 protein expression and secreting a plethora of pro-inflammatory cytokines (IL-1 ß, TGF-ß), growth factors (b-FGF, PDGF, VEGF) in addition to extra cellular matrix components (fibronectin, laminin, collagens)...
March 20, 2020: British Journal of Haematology
https://read.qxmd.com/read/32196643/focal-splenic-lesions-in-indolent-b-nhl-association-with-high-grade-transformation-and-safe-percutaneous-biopsy
#19
LETTER
Farheen Mir, Charlotte Wilding, Naami Mcaddy, Nicholas Butterfield, Larissa Sena, Sarah Thompson, Indu Mitra, Kabir Mohammed, Katherine Vroobel, Ayoma Attygalle, Ian Chau, David Cunningham, Claire Dearden, Dima El-Sharkawi, Nicos Fotiadis, Andrew Wotherspoon, Bhupinder Sharma, Sunil Iyengar
No abstract text is available yet for this article.
March 20, 2020: British Journal of Haematology
https://read.qxmd.com/read/32196641/intermittent-granulocyte-maturation-arrest-hypocellular-bone-marrow-and-episodic-normal-neutrophil-count-can-be-associated-with-srp54-mutations-causing-shwachman-diamond-like-syndrome
#20
LETTER
Francesco Saettini, Alessandro Cattoni, Mariella D'Angio', Paola Corti, Silvia Maitz, Fabio Pagni, Davide Seminati, Laura Pezzoli, Maria Iascone, Andrea Biondi, Sonia Bonanomi
No abstract text is available yet for this article.
March 20, 2020: British Journal of Haematology
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