journal
https://read.qxmd.com/read/38392652/preoperative-glycosylated-haemoglobin-screening-to-identify-older-adult-patients-with-undiagnosed-diabetes-mellitus-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Robert van Wilpe, Mark L van Zuylen, Jeroen Hermanides, J Hans DeVries, Benedikt Preckel, Abraham H Hulst
More than 25% of older adults in Europe have diabetes mellitus. It is estimated that 45% of patients with diabetes are currently undiagnosed, which is a known risk factor for perioperative morbidity. We investigated whether routine HbA1c screening in older adult patients undergoing surgery would identify patients with undiagnosed diabetes. We included patients aged ≥65 years without a diagnosis of diabetes who visited the preoperative assessment clinic at the Amsterdam University Medical Center and underwent HbA1c screening within three months before surgery...
February 19, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392651/non-pharmacological-intervention-for-personalizing-sleep-quality-through-gentle-rocking-motion
#2
JOURNAL ARTICLE
Damiana-Maria Vulturar, Liviu-Ștefan Moacă, Ioana Maria Chețan, Ștefan Cristian Vesa, Teodora-Gabriela Alexescu, Cristina Grigorescu, Antigona Carmen Trofor, Mirela-Anca Stoia, Alexandra Floriana Nemes, Doina-Adina Todea
INTRODUCTION: Achieving restorative sleep is crucial for overall well-being, yet sleep difficulties affect a substantial portion of the adult population. Sleep disturbances are associated with diminished quality of life, physical complaints, cognitive impairment, and emotional regulation challenges. OBJECTIVE: This study explores the influence of an innovative experimental bed designed to generate rocking motions on sleep parameters. METHODS: A prospective observational study enrolled 60 adult participants, assessing their sleep on a regular stationary bed and the Inoveris bed, providing gentle rocking movements...
February 19, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392650/microbiome-dynamics-a-paradigm-shift-in-combatting-infectious-diseases
#3
REVIEW
Mohamed Kamel, Sami Aleya, Majed Alsubih, Lotfi Aleya
Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease-the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host-pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases...
February 18, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392649/mechanical-thrombectomy-via-transbrachial-approach-in-the-emergency-management-of-acute-ischemic-stroke-patients-with-aortic-pathologies-our-experience-and-literature-review
#4
REVIEW
Aida Iancu, Raluca Tudor, Dana Simona Chita, Catalin Juratu, Anca Tudor, Florina Buleu, Daian Popa, Silviu Brad
STUDY DESIGN: Mechanical thrombectomy (MT) via the transbrachial approach (TBA) is a very rare option used in cases of patients with aortic pathologies and acute ischemic stroke (AIS) due to the insufficient evidence in the literature, the difficulty from a technical point of view and the result of this technique influenced by the complications that frequently accompany it. BACKGROUND: Only a few cases of patients with aortic pathologies and acute ischemic stroke where MT via TBA were reported in the literature, and its application in the emergency management of AIS has still not been dealt with in detail...
February 18, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392648/performance-in-behavioral-testing-in-an-animal-model-of-post-surgical-hypoparathyroidism
#5
JOURNAL ARTICLE
Cristina Dettori, Francesca Ronca, Giulia Di Buono, Alessandro Saba, Francesca Di Lupo, Beatrice Polini, Caterina Ricardi, Sabina Frascarelli, Filomena Cetani, Claudio Marcocci, Riccardo Zucchi, Grazia Chiellini, Marco Scalese, Federica Saponaro
BACKGROUND: Hypoparathyroidism (HypoPT) is characterized by hypocalcemia and undetectable/inappropriately low PTH. Post-surgical HypoPT (PS-HypoPT) is the most common cause. Patients with PS-HypoPT present neuropsychological symptoms, probably due to the PTH deprivation in the central nervous system (CNS). However, these mechanisms are still not elucidated. The aim of this study was to evaluate the effects of PTH deprivation on CNS in an animal model of PS-HypoPT via a cognitive/behavioral assessment approach...
February 17, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392647/assessing-the-impact-of-organ-failure-and-metastases-on-quality-of-life-in-breast-cancer-patients-a-prospective-study-based-on-utilizing-eortc-qlq-c30-and-eortc-qlq-br45-questionnaires-in-romania
#6
JOURNAL ARTICLE
Andreea-Iuliana Ionescu Miron, Alexandra-Valentina Anghel, Ionuț-Lucian Antone-Iordache, Dimitrie-Ionuț Atasiei, Cătălin-Alexandru Anghel, Andrei-Alexandru Barnonschi, Alexandra-Maria Bobolocu, Catinca Verga, Florica Șandru, Horia-Dan Lișcu
Breast cancer (BC) significantly impacts the quality of life (QoL) of affected individuals. This study, conducted at Colțea Clinical Hospital, Bucharest, aimed to assess the impact of organ failures and metastases on QoL in breast cancer patients using EORTC QLQ-C30 and EORTC QLQ-BR45 questionnaires and the survival rate to understand the clinical journey and the quality of life status in breast cancer patients. From January 2019 to October 2022, a prospective, observational study surveyed 874 patients, revealing 201 fatalities, 66 refusals, and 607 eligible participants...
February 16, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392646/-lpl-rs264-procr-rs867186-and-pdgf-rs974819-gene-polymorphisms-in-patients-with-unstable-angina
#7
JOURNAL ARTICLE
Damian Malinowski, Krzysztof Safranow, Andrzej Pawlik
BACKGROUND: Coronary artery disease is caused by changes in the coronary arteries due to the atherosclerotic process and thrombotic changes. A very important role in the development of the atherosclerotic process in the coronary vessels is played by the inflammatory process and the immune response. Due to the important role of lipids and the coagulation process in the atherosclerotic process, research has also focused on genes affecting lipid metabolism and the coagulation system. Lipoprotein lipase (LPL) is an enzyme that metabolises lipids, hydrolysing triglycerides to produce free fatty acids and glycerol...
February 16, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392645/impacts-of-neoadjuvant-chemotherapy-on-perioperative-outcomes-in-patients-with-bladder-cancer-treated-with-radical-cystectomy-a-single-high-volume-center-experience
#8
JOURNAL ARTICLE
Flavia Proietti, Rocco Simone Flammia, Leslie Claire Licari, Eugenio Bologna, Alfredo Maria Bove, Aldo Brassetti, Gabriele Tuderti, Riccardo Mastroianni, Antonio Tufano, Giuseppe Simone, Costantino Leonardo
(1) Background: Less than 30% of patients with muscle-invasive bladder cancer (MIBC) receive neoadjuvant chemotherapy (NAC), and reasons for underuse remain unclear. One potential explanation is the concern for the increased risk of perioperative morbidity and mortality. The aim of this study is to investigate the impact of NAC on the risk of detrimental perioperative outcomes in patients with MIBC treated with radical cystectomy (RC). (2) Methods: We identified patients receiving RC for MIBC (T2-4a N0 M0) from 2016 to 2022...
February 16, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392644/individualized-perioperative-hemodynamic-management-using-hypotension-prediction-index-software-and-the-dynamics-of-troponin-and-ntprobnp-concentration-changes-in-patients-undergoing-oncological-abdominal-surgery
#9
JOURNAL ARTICLE
Jolanta Cylwik, Małgorzata Celińska-Spodar, Mariusz Dudzic
INTRODUCTION: Abdominal oncologic surgeries pose significant risks due to the complexity of the surgery and patients' often weakened health, multiple comorbidities, and increased perioperative hazards. Hypotension is a major risk factor for perioperative cardiovascular complications, necessitating individualized management in modern anesthesiology. AIM: This study aimed to determine the dynamics of changes in troponin and NTproBNP levels during the first two postoperative days in patients undergoing major cancer abdominal surgery with advanced hemodynamic monitoring including The AcumenTM Hypotension Prediction Index software (HPI) (Edwards Lifesciences, Irvine, CA, USA) and their association with the occurrence of postoperative cardiovascular complications...
February 16, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392643/performance-of-a-machine-learning-algorithm-to-predict-hypotension-in-spontaneously-breathing-non-ventilated-post-anesthesia-and-icu-patients
#10
JOURNAL ARTICLE
Johan T M Tol, Lotte E Terwindt, Santino R Rellum, Marije Wijnberge, Björn J P van der Ster, Eline Kho, Markus W Hollmann, Alexander P J Vlaar, Denise P Veelo, Jimmy Schenk
Background : Hypotension is common in the post-anesthesia care unit (PACU) and intensive care unit (ICU), and is associated with adverse patient outcomes. The Hypotension Prediction Index (HPI) algorithm has been shown to accurately predict hypotension in mechanically ventilated patients in the OR and ICU and to reduce intraoperative hypotension (IOH). Since positive pressure ventilation significantly affects patient hemodynamics, we performed this validation study to examine the performance of the HPI algorithm in a non-ventilated PACU and ICU population...
February 15, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392642/influence-of-curved-video-laryngoscope-blade-sizes-and-patient-heights-on-video-laryngoscopic-views-a-randomized-controlled-trial
#11
JOURNAL ARTICLE
Jong-Ho Kim, Bo-Reum Cheon, Hyesook Kim, Sung-Mi Hwang, Jae-Jun Lee, Young-Suk Kwon
This study aimed to compare the video laryngoscope views facilitated by curved blades 3 and 4 with an exploration of the relationship between these views and patient height. Conducted as a randomized controlled trial, this study enrolled adults scheduled for surgery under general anesthesia. Intubation procedures were recorded, and the percentage of glottic opening was measured before tube insertion. Multivariate analysis validated the impact of various factors, including blade size and patient height, on the percentage of glottic opening scores...
February 15, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392641/usefulness-of-procalcitonin-levels-for-predicting-the-microbiological-orientation-in-patients-with-sepsis
#12
JOURNAL ARTICLE
Natalia Fernanda Pascual Gómez, María Del Pilar Sanz Martín, María Auxiliadora Semiglia Chong, Nelly Daniela Zurita Cruz, Rosa Méndez Hernández, Iñigo Guerra Molina, Iñigo García Sanz, Angels Figuerola Tejerina, Fernando Ramasco Rueda
The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis that includes 371 patients with a mean age of 71.7 ± 15.6 years who were diagnosed with sepsis or septic shock. The yield of blood cultures in demonstrating the causative microbiological agent was 24.3% (90), and it was 57, 1% (212) when evaluating all types of cultures...
February 15, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392640/the-role-of-cone-beam-computed-tomography-in-periodontology-from-3d-models-of-periodontal-defects-to-3d-printed-scaffolds
#13
JOURNAL ARTICLE
Styliani Verykokou, Charalabos Ioannidis, Sofia Soile, Christos Angelopoulos, Konstantinos Theodoridis, Athanasios S Arampatzis, Andreana N Assimopoulou, Dimitrios Christofilos, Afroditi Kapourani, Ioannis Pantazos, Panagiotis Barmpalexis, Argyro-Maria Boutsi, Chryssy Potsiou
The treatment of osseous defects around teeth is a fundamental concern within the field of periodontology. Over the years, the method of grafting has been employed to treat bone defects, underscoring the necessity for custom-designed scaffolds that precisely match the anatomical intricacies of the bone cavity to be filled, preventing the formation of gaps that could allow the regeneration of soft tissues. In order to create such a patient-specific scaffold (bone graft), it is imperative to have a highly detailed 3D representation of the bone defect, so that the resulting scaffold aligns with the ideal anatomical characteristics of the bone defect...
February 14, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392639/exploring-an-innovative-approach-integrating-negative-pressure-wound-therapy-with-silver-nanoparticle-dressings-in-skin-graft-procedures
#14
JOURNAL ARTICLE
Abdalah Abu-Baker, Andrada-Elena Țigăran, Teodora Peligrad, Daniela-Elena Ion, Daniela-Elena Gheoca-Mutu, Adelaida Avino, Cristian-Sorin Hariga, Oriana Elena Moraru, Laura Răducu, Radu-Cristian Jecan
BACKGROUND: Skin grafting is a helpful instrument in a plastic surgeon's arsenal. Several types of dressings were designed to facilitate the process of graft integration. Negative-pressure wound therapy is a proven dressing method, enhancing graft survival through several mechanisms: aspiration of secretions, stimulation of neoangiogenesis, and promotion of an anti-inflammatory environment. Silver nanoparticle dressings also bring multiple benefits by bearing an antimicrobial effect and providing a humid medium, which are favorable for epithelialization...
February 14, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392638/laparoscopic-management-of-multiple-liver-omental-mesenteric-peritoneal-and-round-ligament-hydatid-cysts-a-rare-report-of-a-case-and-a-systematic-literature-review
#15
REVIEW
Alin Mihetiu, Dan Georgian Bratu, Ciprian Tanasescu, Bogdan Ioan Vintilă, Alexandra Sandu, Mariana Sandu, Dragos Serban, Dan Sabau, Adrian Hasegan
Hydatid cyst disease is a parasitic ailment with an endemic nature, predominantly affecting geographical areas with a tradition in animal husbandry. The most common localization of hydatid disease is in the liver (60%), followed by the lungs, with other organ localizations comprising less than 10%. The surgical approach to this condition can be carried out through open surgery or laparoscopy. The coexistence of hepatic and intraperitoneal hydatidosis often leads to the preference for open surgery. We performed a literature review aiming to retrieve data regarding demographic characteristics, clinical features, preoperative management, and surgical approach concerning these unusual localizations of hydatid disease...
February 14, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392637/efficacy-of-filter-trocar-for-clear-visualization-during-laparoscopic-cholecystectomy-a-prospective-randomized-controlled-trial
#16
JOURNAL ARTICLE
Ho-Chang Chae, Beom-Jin Kim, Yoo Shin Choi, Suk-Won Suh, Seung Eun Lee
Filter trocar designed to eliminate harmful smoke is also regarded as effective for improving surgical visualization. The aim of this study is to evaluate the efficacy of filter trocar in maintaining clear operative view. From 2019 to 2020, 100 patients underwent laparoscopic cholecystectomy and they were randomized to either the control or filter group. The primary end point was a laparoscopic operative view score (1, clear; 2, slightly blurry; 3, completely blurry) during gallbladder dissection from the liver bed when dissection was started (LV1), when dissection was half completed (LV2) and when dissection was completed (LV3)...
February 13, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392636/leveraging-machine-learning-for-personalized-wearable-biomedical-devices-a-review
#17
REVIEW
Ali Olyanasab, Mohsen Annabestani
This review investigates the convergence of artificial intelligence (AI) and personalized health monitoring through wearable devices, classifying them into three distinct categories: bio-electrical, bio-impedance and electro-chemical, and electro-mechanical. Wearable devices have emerged as promising tools for personalized health monitoring, utilizing machine learning to distill meaningful insights from the expansive datasets they capture. Within the bio-electrical category, these devices employ biosignal data, such as electrocardiograms (ECGs), electromyograms (EMGs), electroencephalograms (EEGs), etc...
February 13, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392635/multiple-sclerosis-research-evolves-a-closer-look-at-deep-gray-matter-sexual-function-rehabilitation-and-t-regulatory-cells
#18
EDITORIAL
Majid Ghareghani, Serge Rivest
Multiple sclerosis (MS) is a chronic autoimmune condition that leads to the loss of myelin and, subsequently, neuronal damage in the central nervous system (CNS) [...].
February 12, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392634/sex-differences-in-cardiac-and-clinical-phenotypes-and-their-relation-to-outcomes-in-patients-with-heart-failure
#19
REVIEW
Akane Kawai, Yuji Nagatomo, Midori Yukino-Iwashita, Ryota Nakazawa, Yusuke Yumita, Akira Taruoka, Asako Takefuji, Risako Yasuda, Takumi Toya, Yukinori Ikegami, Nobuyuki Masaki, Takeshi Adachi
Biological sex is one of the major factors characterizing the heart failure (HF) patient phenotype. Understanding sex-related differences in HF is crucial to implement personalized care for HF patients with various phenotypes. There are sex differences in left ventricular (LV) remodeling patterns in the HF setting, namely, more likely concentric remodeling and diastolic dysfunction in women and eccentric remodeling and systolic dysfunction in men. Recently supra-normal EF (snLVEF) has been recognized as a risk of worse outcome...
February 12, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392633/mind-body-training-a-plausible-strategy-against-osteomuscular-chronic-pain-a-systematic-review-with-meta-analysis
#20
REVIEW
Julia Gámez-Iruela, Agustín Aibar-Almazán, Diego Fernando Afanador-Restrepo, Yolanda Castellote-Caballero, Fidel Hita-Contreras, María Del Carmen Carcelén-Fraile, Ana María González-Martín
(1) Background: Chronic pain, which affects more than one in five adults worldwide, has a negative impact on the quality of life, limiting daily activities and generating absences from work. The aim of the present review is to analyze the efficacy of mind-body therapies as therapeutic strategies for patients with chronic pain. (2) Methods: A systematic review with a meta-analysis was carried out, searching PubMed, Scopus, and Web of Science databases using specific keywords. We selected studies that included mind-body therapies as the primary intervention for older adults with chronic pain...
February 11, 2024: Journal of Personalized Medicine
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