journal
https://read.qxmd.com/read/37623532/soluble-transferrin-receptor-as-iron-deficiency-biomarker-impact-on-exercise-capacity-in-heart-failure-patients
#1
JOURNAL ARTICLE
Maria Del Mar Ras-Jiménez, Raúl Ramos-Polo, Josep Francesch Manzano, Miriam Corbella Santano, Herminio Morillas Climent, Núria Jose-Bazán, Santiago Jiménez-Marrero, Paloma Garcimartin Cerezo, Sergi Yun Viladomat, Pedro Moliner Borja, Blanca Torres Cardús, José Maria Verdú-Rotellar, Carles Diez-López, José González-Costello, Elena García-Romero, Fernando de Frutos Seminario, Laura Triguero-Llonch, Cristina Enjuanes Grau, Marta Tajes Orduña, Josep Comin-Colet
The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1...
August 21, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623531/progress-in-research-on-stem-cells-in-neonatal-refractory-diseases
#2
REVIEW
Fangjun Huang, Yang He, Meng Zhang, Keren Luo, Jiawen Li, Jiali Li, Xinyu Zhang, Xiaoyan Dong, Jun Tang
With the development and progress of medical technology, the survival rate of premature and low-birth-weight infants has increased, as has the incidence of a variety of neonatal diseases, such as hypoxic-ischemic encephalopathy, intraventricular hemorrhage, bronchopulmonary dysplasia, necrotizing enterocolitis, and retinopathy of prematurity. These diseases cause severe health conditions with poor prognoses, and existing control methods are ineffective for such diseases. Stem cells are a special type of cells with self-renewal and differentiation potential, and their mechanisms mainly include anti-inflammatory and anti-apoptotic properties, reducing oxidative stress, and boosting regeneration...
August 21, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623530/an-innovative-scoring-system-to-select-the-optimal-surgery-in-breast-cancer-after-neoadjuvant-chemotherapy
#3
JOURNAL ARTICLE
Antonio Franco, Alba Di Leone, Marco Conti, Alessandra Fabi, Luisa Carbognin, Andreina Daniela Terribile, Paolo Belli, Armando Orlandi, Martin Alejandro Sanchez, Francesca Moschella, Elena Jane Mason, Giovanni Cimino, Alessandra De Filippis, Fabio Marazzi, Ida Paris, Giuseppe Visconti, Liliana Barone Adesi, Lorenzo Scardina, Sabatino D'Archi, Marzia Salgarello, Diana Giannarelli, Riccardo Masetti, Gianluca Franceschini
INTRODUCTION: The selection of surgery post-neoadjuvant chemotherapy (NACT) is difficult and based on surgeons' expertise. The aim of this study was to create a post-NEoadjuvant Score System (pNESSy) to choose surgery, optimizing oncological and aesthetical outcomes. METHODS: Patients (stage I-III) underwent surgery post-NACT (breast-conserving surgery (BCS), oncoplastic surgery (OPS), and conservative mastectomy (CMR) were included. Data selected were BRCA mutation, ptosis, breast volume, radiological response, MRI, and mammography pre- and post-NACT prediction of excised breast area...
August 21, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623529/preoperative-lower-limb-muscle-predictors-for-gait-speed-improvement-after-total-hip-arthroplasty-for-patients-with-osteoarthritis
#4
JOURNAL ARTICLE
Tadashi Yasuda, Satoshi Ota, Sadaki Mitsuzawa, Shinnosuke Yamashita, Yoshihiro Tsukamoto, Hisataka Takeuchi, Eijiro Onishi
This study aimed to identify preoperative lower-limb muscle predictors for gait speed improvement after total hip arthroplasty (THA) with hip osteoarthritis. Gait speed improvement was evaluated as the subtraction of preoperative speed from postoperative speed. The preoperative muscle composition of ipsilateral hip abductors was evaluated using computed tomography. The females ( n = 45) showed smaller total cross-sectional areas of the gluteal muscles than the males ( n = 13). The gluteus maximus in the females showed lower lean muscle mass area (LMM) and higher ratios of the intramuscular fat area and the intramuscular adipose tissue area to the total muscle area (TM) than the males...
August 20, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623528/cortical-subcortical-functional-preservation-and-rehabilitation-in-neuro-oncology-tractography-mips-ionm-tms-proof-of-concept-study
#5
JOURNAL ARTICLE
Francesca Vitulli, Dimitrios Kalaitzoglou, Christos Soumpasis, Alba Díaz-Baamonde, José David Siado Mosquera, Richard Gullan, Francesco Vergani, Keyoumars Ashkan, Ranjeev Bhangoo, Ana Mirallave-Pescador, Jose Pedro Lavrador
Surgical management of deep-seated brain tumors requires precise functional navigation and minimally invasive surgery. Preoperative mapping using navigated transcranial magnetic stimulation (nTMS), intraoperative neurophysiological monitoring (IONM), and minimally invasive parafascicular surgery (MIPS) act together in a functional-sparing approach. nTMS also provides a rehabilitation tool to maximize functional recovery. This is a single-center retrospective proof-of-concept cohort study between January 2022 and June 2023 of patients admitted for surgery with motor eloquent deep-seated brain tumors...
August 20, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623527/attenuated-total-reflection-fourier-transform-infrared-spectral-discrimination-in-human-tissue-of-oesophageal-transformation-to-adenocarcinoma
#6
JOURNAL ARTICLE
Ishaan Maitra, Camilo L M Morais, Kássio M G Lima, Katherine M Ashton, Danielle Bury, Ravindra S Date, Francis L Martin
This study presents ATR-FTIR (attenuated total reflectance Fourier-transform infrared) spectral analysis of ex vivo oesophageal tissue including all classifications to oesophageal adenocarcinoma (OAC). The article adds further validation to previous human tissue studies identifying the potential for ATR-FTIR spectroscopy in differentiating among all classes of oesophageal transformation to OAC. Tissue spectral analysis used principal component analysis quadratic discriminant analysis (PCA-QDA), successive projection algorithm quadratic discriminant analysis (SPA-QDA), and genetic algorithm quadratic discriminant analysis (GA-QDA) algorithms for variable selection and classification...
August 20, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623526/evaluation-of-the-performance-of-otoplan-based-cochlear-implant-electrode-array-selection-a-retrospective-study
#7
JOURNAL ARTICLE
Dayse Távora-Vieira, Marcus Voola, Jafri Kuthubutheen, Peter Friedland, Daren Gibson, Aanand Acharya
Otoplan is a surgical planning software designed to assist with cochlear implant surgery. One of its outputs is a recommendation of electrode array type based on imaging parameters. In this retrospective study, we evaluated the differences in auditory outcomes between patients who were implanted with arrays corresponding to those recommended by the Otoplan software versus those in which the array selection differed from the Otoplan recommendation. Pre-operative CT images from 114 patients were imported into the software, and array recommendations were generated...
August 20, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623525/personal-health-record-phr-experience-and-recommendations-for-a-transformation-in-saudi-arabia
#8
JOURNAL ARTICLE
Abdullah Alanazi, Mohammed Alanazi, Bakheet Aldosari
A Personal Health Record (PHR) is a patient-managed platform for health data. Most hospitals provide a PHR as an extension of the Electronic Medical Record (EMR). However, there are unresolved issues around the adoption rate, functionalities, barriers and, more importantly, the impact of the PHR on patients' health. A cross-sectional, survey-based descriptive study was conducted in which patients from four main tertiary hospitals in Saudi Arabia were targeted from September 2022 to February 2023. The survey was tested and validated to address the objectives of the study...
August 19, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623524/efficacy-of-combined-photobiomodulation-therapy-with-supplements-versus-supplements-alone-in-restoring-thyroid-gland-homeostasis-in-hashimoto-thyroiditis-a-clinical-feasibility-parallel-trial-with-6-months-follow-up
#9
JOURNAL ARTICLE
Venera Berisha-Muharremi, Bernard Tahirbegolli, Ruth Phypers, Reem Hanna
Hashimoto thyroiditis (HT) is a thyroid-specific autoimmune disorder, triggering hypothyroidism in a population with an adequate dietary intake. Despite the current conventional treatment focuses on the permanent replacement of levothyroxine (LT4) deficiency, it appears that thyroid autoimmunity remains the cause of persistent symptoms in patients with HT, even when they achieve to be euthyroid from a biochemical standpoint. Photobiomodulation (PBM) showed to be an effective therapy in the management of autoimmune diseases, but with limited evidence...
August 19, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623523/characteristics-of-kidney-transplant-recipients-with-prolonged-pre-transplant-dialysis-duration-as-identified-by-machine-learning-consensus-clustering-pathway-to-personalized-care
#10
JOURNAL ARTICLE
Charat Thongprayoon, Supawit Tangpanithandee, Caroline C Jadlowiec, Shennen A Mao, Michael A Mao, Pradeep Vaitla, Prakrati C Acharya, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawadee Suppadungsuk, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Iasmina M Craici, Wisit Cheungpasitporn
Longer pre-transplant dialysis duration is known to be associated with worse post-transplant outcomes. Our study aimed to cluster kidney transplant recipients with prolonged dialysis duration before transplant using an unsupervised machine learning approach to better assess heterogeneity within this cohort. We performed consensus cluster analysis based on recipient-, donor-, and transplant-related characteristics in 5092 kidney transplant recipients who had been on dialysis ≥ 10 years prior to transplant in the OPTN/UNOS database from 2010 to 2019...
August 19, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623522/acute-changes-on-left-atrial-function-during-incremental-exercise-in-patients-with-heart-failure-with-mildly-reduced-ejection-fraction-a-case-control-study
#11
JOURNAL ARTICLE
Marco Alfonso Perrone, Ferdinando Iellamo, Valentino D'Antoni, Alessandro Gismondi, Deborah Di Biasio, Sara Vadalà, Giuseppe Marazzi, Valentina Morsella, Maurizio Volterrani, Giuseppe Caminiti
BACKGROUND: the aim of this study was to assess acute changes in left atrial (LA) function during incremental aerobic exercise in patients with heart failure with mildly reduced ejection fraction (HFmrEF) in comparison to healthy subjects (HS). METHODS: twenty patients with established HFmrEF were compared with 10 HS, age-matched controls. All subjects performed a stepwise exercise test on a cycle ergometer. Echocardiography was performed at baseline, during submaximal effort, at peak of exercise, and after 5 min of recovery...
August 18, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623521/the-rising-problem-of-hip-fractures-in-geriatric-patients-analysis-of-surgical-influences-on-the-outcome
#12
JOURNAL ARTICLE
Julian Krickl, Till Ittermann, Andreas Thannheimer, Wolfgang Schmidt, Maximilian Willauschus, Johannes Ruether, Kim Loose, Markus Gesslein, Michael Millrose
BACKGROUND: Hip fractures in geriatric patients often have a poor outcome in terms of mortality, mobility as well as independence. Different surgical influence factors are known that improve the outcome. METHODS: In this observational cohort study, 281 patients of a geriatric trauma unit were analyzed prospectively. Demographic factors, as well as data regarding the trauma mechanism and perioperative treatment, were recorded. The nutritional status was also analyzed...
August 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623520/comprehensive-molecular-evaluation-of-hnf-1-alpha-mir-27a-and-mir-146-gene-variants-and-their-link-with-predisposition-and-progression-in-type-2-diabetes-patients
#13
JOURNAL ARTICLE
Rashid Mir, Imadeldin Elfaki, M E Elangeeb, Mamdoh S Moawadh, Faris Jamal Tayeb, Jameel Barnawi, Ibrahim Altedlawi Albalawi, Amnah A Alharbi, Marwan H Alhelali, Basim S O Alsaedi
BACKGROUND: Type 2 diabetes (T2D) is a metabolic condition induced by insulin resistance and pancreatic beta cell dysfunction. MicroRNAs (miRNAs) have biological significance because they regulate processes such as the molecular signaling pathways involved in the pathophysiology of diabetes mellitus. The hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is a transcription factor found in hepatocytes and the pancreas. Mutations in the HNF-1 alpha gene were reportedly associated with maturity-onset diabetes of the young (MODY)...
August 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623519/efficacy-of-personalized-foot-orthoses-in-children-with-flexible-flat-foot-protocol-for-a-randomized-controlled-trial
#14
JOURNAL ARTICLE
Cristina Molina-García, Andrés Reinoso-Cobo, Jonathan Cortés-Martín, Eva Lopezosa-Reca, Ana Marchena-Rodriguez, George Banwell, Laura Ramos-Petersen
Pediatric flat foot (PFF) is a very frequent entity and a common concern for parents and health professionals. There is no established definition, diagnostic method, or clear treatment approach. There are multiple conservative and surgical treatments, the implantation of foot orthoses (FO) being the most used treatment. The evidence supporting FO is very thin. It is not clearly known what the effect of these is, nor when it is convenient to recommend them. The main objective of this protocol is to design a randomized controlled trial to determine if personalized FO, together with a specific exercise regimen, produce the same or better results regarding the signs and symptoms of PFF, compared to only specific exercises...
August 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623518/artificial-intelligence-based-methods-for-precision-cardiovascular-medicine
#15
REVIEW
Farida Mohsen, Balqees Al-Saadi, Nima Abdi, Sulaiman Khan, Zubair Shah
Precision medicine has the potential to revolutionize the way cardiovascular diseases are diagnosed, predicted, and treated by tailoring treatment strategies to the individual characteristics of each patient. Artificial intelligence (AI) has recently emerged as a promising tool for improving the accuracy and efficiency of precision cardiovascular medicine. In this scoping review, we aimed to identify and summarize the current state of the literature on the use of AI in precision cardiovascular medicine. A comprehensive search of electronic databases, including Scopes, Google Scholar, and PubMed, was conducted to identify relevant studies...
August 16, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623517/lessons-learned-from-the-covid-19-pandemic-a-survey-based-study-on-a-sample-of-italian-physicians-opinions-on-telemedicine
#16
JOURNAL ARTICLE
Pamela Tozzo, Arianna Delicati, Beatrice Marcante, Dolores Catelan, Luciana Caenazzo
Telemedicine was born out of the need to ensure clinical evaluation and personal care regardless of the physical presence of the healthcare professional nearby. Information technologies have been vital during the COVID-19 pandemic to ensure medical care and avoid the contagion between patients and clinicians. Accordingly, telecare services multiplied worldwide and gained paramount importance. The present work aims to collect field-based opinions about Telemedicine and ethics among Italian physicians. We developed a web-based questionnaire that was administered to Italian physicians from 1 May to 15 June 2022...
August 16, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623516/total-intravenous-anesthesia-protocol-for-decreasing-unacceptable-movements-during-cerebral-aneurysm-clipping-with-motor-evoked-potential-monitoring-a-historical-control-study-and-meta-analysis
#17
JOURNAL ARTICLE
Yong-Seok Park, Yong-Seo Koo, Seungil Ha, Sangho Lee, Ji-Hoon Sim, Joung Uk Kim
Injury can occur during intraoperative transcranial motor-evoked potential (MEP) monitoring caused by patient movement related to insufficient neuromuscular blocking agent use. Here, we evaluated the incidence of unacceptable movements in patients undergoing intraoperative MEP monitoring following our anesthetic protocol. We reviewed the anesthesia records of 419 patients who underwent unruptured cerebral aneurysm clipping with intraoperative MEP monitoring. The anesthetic protocol included target-controlled infusion with a fixed effect-site propofol concentration of 3 μg/mL and an adjustable effect-site remifentanil concentration of 10-12 ng/mL...
August 16, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623515/the-influence-of-cardiac-arrest-floor-level-location-within-a-building-on-survival-outcomes
#18
JOURNAL ARTICLE
Chiwon Ahn, Young Taeck Oh, Yeonkyung Park, Jae Hwan Kim, Sojune Hwang, Moonho Won
This nationwide, population-based observational study investigated the association between the floor level of out-of-hospital cardiac arrest (OHCA) incidence and survival outcomes in South Korea, notable for its significant high-rise apartment living. Data were collected retrospectively from OHCA patients through the South Korean Out-of-Hospital Cardiac Arrest Surveillance database. The study incorporated cases that included the OHCA's building floor information. The primary outcome assessed was survival to discharge, analyzed using multivariate logistic regression, and the secondary outcome was favorable neurological outcome...
August 16, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623514/the-role-of-oxidative-stress-in-infertility
#19
JOURNAL ARTICLE
Ioana Zaha, Mariana Muresan, Camelia Tulcan, Anca Huniadi, Petronela Naghi, Mircea Sandor, Roberta Tripon, Cristina Gaspar, Major Klaudia-Melinda, Liliana Sachelarie, Liana Stefan
(1) Background: Oxidative stress markers in the follicular fluid and serum of the patient with IVF results (number of fertilized oocytes, number of embryos, cumulative pregnancy rate) are important in establishing the causes of infertility. (2) Methods: 42 patients were enrolled in the study over the duration of 24 months and were divided into two groups: the study group divided into the female etiology for infertility as a tubal factor, diminished ovarian reserve, endometriosis, and unexplained infertility, and the control group consisting of the male factor, excluding the sperm donors and with no female factor cause...
August 15, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37623513/charting-the-path-navigating-embryonic-development-to-potentially-safeguard-against-congenital-heart-defects
#20
REVIEW
José Bragança, Rute Pinto, Bárbara Silva, Nuno Marques, Helena S Leitão, Mónica T Fernandes
Congenital heart diseases (CHDs) are structural or functional defects present at birth due to improper heart development. Current therapeutic approaches to treating severe CHDs are primarily palliative surgical interventions during the peri- or prenatal stages, when the heart has fully developed from faulty embryogenesis. However, earlier interventions during embryonic development have the potential for better outcomes, as demonstrated by fetal cardiac interventions performed in utero, which have shown improved neonatal and prenatal survival rates, as well as reduced lifelong morbidity...
August 15, 2023: Journal of Personalized Medicine
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