journal
https://read.qxmd.com/read/37750893/continuous-glucose-monitoring-derived-time-in-range-and-cv-are-associated-with-altered-tissue-characteristics-of-the-carotid-artery-wall-in-people-with-type-2-diabetes
#1
JOURNAL ARTICLE
Tomoya Mita, Naoto Katakami, Yosuke Okada, Hidenori Yoshii, Takeshi Osonoi, Keiko Nishida, Toshihiko Shiraiwa, Akira Kurozumi, Naohiro Taya, Satomi Wakasugi, Fumiya Sato, Ryota Ishii, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
AIMS/HYPOTHESIS: Previous studies have suggested that glucose variability may accelerate atherosclerosis progression in people with type 2 diabetes. Current guidelines recommend assessing glycaemic control using continuous glucose monitoring (CGM), which provides a comprehensive glycaemic profile to supplement HbA1c measurement. However, the association between CGM-derived metrics and atherosclerosis progression is not entirely clear. METHODS: This exploratory study used baseline data and data obtained after 104 weeks from an ongoing prospective, multicentre, observational study...
September 26, 2023: Diabetologia
https://read.qxmd.com/read/37750892/presymptomatic-type-1-diabetes-and-disease-severity-at-onset
#2
LETTER
Josephine Schneider, Gita Gemulla, Wieland Kiess, Reinhard Berner, Angela Hommel
No abstract text is available yet for this article.
September 26, 2023: Diabetologia
https://read.qxmd.com/read/37728732/the-challenges-of-identifying-and-studying-type-1-diabetes-in-adults
#3
REVIEW
Nicholas J Thomas, Angus G Jones
Diagnosing type 1 diabetes in adults is difficult since type 2 diabetes is the predominant diabetes type, particularly with an older age of onset (approximately >30 years). Misclassification of type 1 diabetes in adults is therefore common and will impact both individual patient management and the reported features of clinically classified cohorts. In this article, we discuss the challenges associated with correctly identifying adult-onset type 1 diabetes and the implications of these challenges for clinical practice and research...
September 20, 2023: Diabetologia
https://read.qxmd.com/read/37728731/structural-changes-in-schwann-cells-and-nerve-fibres-in-type-1-diabetes-relationship-with-diabetic-polyneuropathy
#4
JOURNAL ARTICLE
Xiaoli Hu, Christian Selmer Buhl, Marie Balle Sjogaard, Karoline Schousboe, Hatice Isik Mizrak, Huda Kufaishi, Troels Staehelin Jensen, Christian Stevns Hansen, Knud Bonnet Yderstræde, Ming-Dong Zhang, Patrik Ernfors, Jens Randel Nyengaard, Pall Karlsson
AIMS/HYPOTHESIS: Our aim was to investigate structural changes of cutaneous Schwann cells (SCs), including nociceptive Schwann cells (nSCs) and axons, in individuals with diabetic polyneuropathy. We also aimed to investigate the relationship between these changes and peripheral neuropathic symptoms in type 1 diabetes. METHODS: Skin biopsies (3 mm) taken from carefully phenotyped participants with type 1 diabetes without polyneuropathy (T1D, n=25), type 1 diabetes with painless diabetic polyneuropathy (T1DPN, n=30) and type 1 diabetes with painful diabetic polyneuropathy (P-T1DPN, n=27), and from healthy control individuals (n=25) were immunostained with relevant antibodies to visualise SCs and nerve fibres...
September 20, 2023: Diabetologia
https://read.qxmd.com/read/37728730/association-between-timing-and-consistency-of-physical-activity-and-type-2-diabetes-a-cohort-study-on-participants-of-the-uk-biobank
#5
JOURNAL ARTICLE
Caiwei Tian, Charlyne Bürki, Kenneth E Westerman, Chirag J Patel
AIMS/HYPOTHESIS: We sought to quantify the relationship between morning, afternoon or evening physical activity and consistency (e.g. routine) and risk of type 2 diabetes. METHODS: A cohort of 93,095 UK Biobank participants (mean age 62 years) without a history of type 2 diabetes wore a wrist-worn accelerometer for 1 week. We converted accelerometer information to estimate metabolic equivalent of task (MET), summing MET h of total physical activity completed within three intra-day time segments (morning, afternoon and evening)...
September 20, 2023: Diabetologia
https://read.qxmd.com/read/37725107/identifying-the-severity-of-diabetic-retinopathy-by-visual-function-measures-using-both-traditional-statistical-methods-and-interpretable-machine-learning-a-cross-sectional-study
#6
JOURNAL ARTICLE
David M Wright, Usha Chakravarthy, Radha Das, Katie W Graham, Timos T Naskas, Jennifer Perais, Frank Kee, Tunde Peto, Ruth E Hogg
AIMS/HYPOTHESIS: To determine the extent to which diabetic retinopathy severity stage may be classified using machine learning (ML) and commonly used clinical measures of visual function together with age and sex. METHODS: We measured the visual function of 1901 eyes from 1032 participants in the Northern Ireland Sensory Ageing Study, deriving 12 variables from nine visual function tests. Missing values were imputed using chained equations. Participants were divided into four groups using clinical measures and grading of ophthalmic images: no diabetes mellitus (no DM), diabetes but no diabetic retinopathy (DM no DR), diabetic retinopathy without diabetic macular oedema (DR no DMO) and diabetic retinopathy with DMO (DR with DMO)...
September 19, 2023: Diabetologia
https://read.qxmd.com/read/37723346/presymptomatic-type-1-diabetes-and-disease-severity-at-onset-reply-to-schneider-j-gemulla-g-kiess-w-et-al-letter
#7
LETTER
Sandra Hummel, Nadine Friedl, Christiane Winkler, Anette-G Ziegler, Peter Achenbach
No abstract text is available yet for this article.
September 19, 2023: Diabetologia
https://read.qxmd.com/read/37715820/racial-ethnic-and-socioeconomic-disparities-in-achievement-of-treatment-goals-within-a-clinical-trial-a-secondary-analysis-of-the-accord-trial
#8
JOURNAL ARTICLE
Sara J Cromer, Tanayott Thaweethai, Deborah J Wexler
AIMS/HYPOTHESIS: Clinical trial participation should theoretically reduce barriers to care by ensuring medication and healthcare access. We aimed to evaluate disparities in achieving diabetes treatment targets by race/ethnicity and educational attainment within the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (ClinicalTrials.gov NCT00000620). METHODS: The ACCORD trial included three interventions of varying participant burden: glycaemic (high burden), blood pressure (medium burden) and triglyceride-lowering (low burden)...
September 16, 2023: Diabetologia
https://read.qxmd.com/read/37712956/quantifying-beta-cell-function-in-the-preclinical-stages-of-type-1-diabetes
#9
REVIEW
Alfonso Galderisi, Alice L J Carr, Mariangela Martino, Peter Taylor, Peter Senior, Colin Dayan
Clinically symptomatic type 1 diabetes (stage 3 type 1 diabetes) is preceded by a pre-symptomatic phase, characterised by progressive loss of functional beta cell mass after the onset of islet autoimmunity, with (stage 2) or without (stage 1) measurable changes in glucose profile during an OGTT. Identifying metabolic tests that can longitudinally track changes in beta cell function is of pivotal importance to track disease progression and measure the effect of disease-modifying interventions. In this review we describe the metabolic changes that occur in the early pre-symptomatic stages of type 1 diabetes with respect to both insulin secretion and insulin sensitivity, as well as the measurable outcomes that can be derived from the available tests...
September 15, 2023: Diabetologia
https://read.qxmd.com/read/37712955/adgrl1-is-a-glucose-receptor-involved-in-mediating-energy-and-glucose-homeostasis
#10
JOURNAL ARTICLE
Kavaljit H Chhabra, Siresha Bathina, Tumininu S Faniyan, Dennis J Samuel, Muhammad Ummear Raza, Leticia Maria de Souza Cordeiro, Gonzalo Viana Di Prisco, Brady K Atwood, Jorge Robles, Lauren Bainbridge, Autumn Davis
AIMS/HYPOTHESIS: The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Although glucose transporters such as GLUT2 and sodium-glucose cotransporter 2 (SGLT2) are known to regulate glucose homeostasis and metabolism, the identity of a receptor that binds glucose to activate glucose signalling pathways in the brain is unknown. In this study, we aimed to discover a glucose receptor in the mouse hypothalamus. METHODS: Here we used a high molecular mass glucose-biotin polymer to enrich glucose-bound mouse hypothalamic neurons through cell-based affinity chromatography...
September 15, 2023: Diabetologia
https://read.qxmd.com/read/37712954/improved-prediction-of-long-term-kidney-outcomes-in-people-with-type-2-diabetes-by-levels-of-circulating-haematopoietic-stem-progenitor-cells
#11
JOURNAL ARTICLE
Benedetta Maria Bonora, Mario Luca Morieri, Marella Marassi, Roberta Cappellari, Angelo Avogaro, Gian Paolo Fadini
AIM/HYPOTHESIS: We examined whether prediction of long-term kidney outcomes in individuals with type 2 diabetes can be improved by measuring circulating levels of haematopoietic stem/progenitor cells (HSPCs), which are reduced in diabetes and are associated with cardiovascular risk. METHODS: We included individuals with type 2 diabetes who had a baseline determination of circulating HSPCs in 2004-2019 at the diabetes centre of the University Hospital of Padua and divided them into two groups based on their median value per ml of blood...
September 15, 2023: Diabetologia
https://read.qxmd.com/read/37710059/up-front
#12
(no author information available yet)
No abstract text is available yet for this article.
September 15, 2023: Diabetologia
https://read.qxmd.com/read/37676480/using-race-as-a-social-construct-when-looking-at-differences-in-racial-associations-between-non-alcoholic-fatty-liver-disease-and-type-2-diabetes
#13
LETTER
Francois G Rollin, Colin Washington, Shelly-Ann Fluker
No abstract text is available yet for this article.
September 7, 2023: Diabetologia
https://read.qxmd.com/read/37670018/retinal-inflammation-in-murine-models-of-type-1-and-type-2-diabetes-with-diabetic-retinopathy
#14
JOURNAL ARTICLE
Subramanian Dharmarajan, Casandra Carrillo, Zhonghua Qi, Jonathan M Wilson, Anthony J Baucum, Christine M Sorenson, Nader Sheibani, Teri L Belecky-Adams
AIMS/HYPOTHESIS: The loss of pericytes surrounding the retinal vasculature in early diabetic retinopathy underlies changes to the neurovascular unit that lead to more destructive forms of the disease. However, it is unclear which changes lead to loss of retinal pericytes. This study investigated the hypothesis that chronic increases in one or more inflammatory factors mitigate the signalling pathways needed for pericyte survival. METHODS: Loss of pericytes and levels of inflammatory markers at the mRNA and protein levels were investigated in two genetic models of diabetes, Ins2Akita/+ (a model of type 1 diabetes) and Leprdb/db (a model of type 2 diabetes), at early stages of diabetic retinopathy...
September 5, 2023: Diabetologia
https://read.qxmd.com/read/37670017/the-metabolic-response-of-human-trophoblasts-derived-from-term-placentas-to-metformin
#15
JOURNAL ARTICLE
Jane L Tarry-Adkins, India G Robinson, Lucas C Pantaleão, Jenna L Armstrong, Benjamin D Thackray, Lorenz M W Holzner, Alice E Knapton, Sam Virtue, Benjamin Jenkins, Albert Koulman, Andrew J Murray, Susan E Ozanne, Catherine E Aiken
AIMS/HYPOTHESIS: Metformin is increasingly used therapeutically during pregnancy worldwide, particularly in the treatment of gestational diabetes, which affects a substantial proportion of pregnant women globally. However, the impact on placental metabolism remains unclear. In view of the association between metformin use in pregnancy and decreased birthweight, it is essential to understand how metformin modulates the bioenergetic and anabolic functions of the placenta. METHODS: A cohort of 55 placentas delivered by elective Caesarean section at term was collected from consenting participants...
September 5, 2023: Diabetologia
https://read.qxmd.com/read/37667106/high-proinsulin-c-peptide-ratio-identifies-individuals-with-stage-2-type-1-diabetes-at-high-risk-for-progression-to-clinical-diagnosis-and-responses-to-teplizumab-treatment
#16
JOURNAL ARTICLE
Emily K Sims, Susan M Geyer, S Alice Long, Kevan C Herold
AIMS/HYPOTHESIS: Tractable precision biomarkers to identify immunotherapy responders are lacking in type 1 diabetes. We hypothesised that proinsulin:C-peptide (PI:C) ratios, a readout of beta cell stress, could provide insight into type 1 diabetes progression and responses to immunotherapy. METHODS: In this post hoc analysis, proinsulin and C-peptide levels were determined in baseline serum samples from 63 participants with stage 2 type 1 diabetes in the longitudinal TrialNet Teplizumab Prevention Study (n=41 in the teplizumab arm; n=22 in the placebo arm)...
September 4, 2023: Diabetologia
https://read.qxmd.com/read/37667105/59-th-easd-annual-meeting-of-the-european-association-for-the-study-of-diabetes-hamburg-germany-2-6-october-2023
#17
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 4, 2023: Diabetologia
https://read.qxmd.com/read/37653058/bringing-precision-medicine-to-the-management-of-pregnancy-in-women-with-glucokinase-mody-a-study-of-diagnostic-accuracy-and-feasibility-of-non-invasive-prenatal-testing
#18
JOURNAL ARTICLE
Alice E Hughes, Jayne A L Houghton, Benjamin Bunce, Ali J Chakera, Gill Spyer, Maggie H Shepherd, Sarah E Flanagan, Andrew T Hattersley
AIMS/HYPOTHESIS: In pregnancies where the mother has glucokinase-MODY (GCK-MODY), fetal growth is determined by fetal genotype. When the fetus inherits a maternal pathogenic GCK variant, normal fetal growth is anticipated, and insulin treatment of maternal hyperglycaemia is not recommended. At present, fetal genotype is estimated from measurement of fetal abdominal circumference on ultrasound. Non-invasive prenatal testing of fetal GCK genotype (NIPT-GCK) using cell-free DNA in maternal blood has recently been developed...
August 31, 2023: Diabetologia
https://read.qxmd.com/read/37650924/cystine-glutamate-antiporter-system-x-c-deficiency-impairs-insulin-secretion-in-mice
#19
JOURNAL ARTICLE
Axel de Baat, Daniel T Meier, Leila Rachid, Adriano Fontana, Marianne Böni-Schnetzler, Marc Y Donath
AIMS/HYPOTHESIS: Glutamate-induced cytotoxicity (excitotoxicity) has been detected in pancreatic beta cells. The cystine/glutamate antiporter System xc - exports glutamate to the extracellular space and is therefore implicated as driving excitotoxicity. As of yet, it has not been investigated whether System xc - contributes to pancreatic islet function. METHODS: This study describes the implications of deficiency of System xc - on glucose metabolism in both constitutive and myeloid cell-specific knockout mice using metabolic tests and diet-induced obesity...
August 31, 2023: Diabetologia
https://read.qxmd.com/read/37615690/lipotoxicity-polarised-macrophage-derived-exosomes-regulate-mitochondrial-fitness-through-miro1-mediated-mitophagy-inhibition-and-contribute-to-type-2-diabetes-development-in-mice
#20
JOURNAL ARTICLE
Jian-Ming Li, Xianyu Li, Lawrence W C Chan, Ruinian Hu, Tian Zheng, Haojie Li, Sijun Yang
AIMS/HYPOTHESIS: Insulin resistance is a major pathophysiological defect in type 2 diabetes and obesity. Numerous experimental and clinical studies have provided evidence that sustained lipotoxicity-induced mitophagy deficiency can exacerbate insulin resistance, leading to a vicious cycle between mitophagy dysfunction and insulin resistance, and thereby the onset of type 2 diabetes. Emerging evidence suggests that exosomes (Exos) from M2 macrophages play an essential role in modulating metabolic homeostasis...
August 24, 2023: Diabetologia
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