Evan L Reynolds, Maya Watanabe, Mousumi Banerjee, Ericka Chant, Emily Villegas-Umana, Melissa A Elafros, Thomas W Gardner, Rodica Pop-Busui, Subramaniam Pennathur, Eva L Feldman, Brian C Callaghan
AIMS/HYPOTHESIS: The aim of this study was to determine the effect of bariatric surgery on diabetes complications in individuals with class II/III obesity (BMI > 35 kg/m2 ). METHODS: We performed a prospective cohort study of participants with obesity who underwent bariatric surgery. At baseline and 2 years following surgery, participants underwent metabolic phenotyping and diabetes complication assessments. The primary outcomes for peripheral neuropathy (PN) were a change in intra-epidermal nerve fibre density (IENFD, units = fibres/mm) at the distal leg and proximal thigh, the primary outcome for cardiovascular autonomic neuropathy (CAN) was a change in the expiration/inspiration (E/I) ratio, and the primary outcome for retinopathy was a change in the mean deviation on frequency doubling technology testing...
March 14, 2023: Diabetologia