journal
https://read.qxmd.com/read/38517484/the-innodia-type-1-diabetes-natural-history-study-a-european-cohort-of-newly-diagnosed-children-adolescents-and-adults
#1
JOURNAL ARTICLE
M Loredana Marcovecchio, A Emile J Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A Todd, Bart Van der Schueren, Linda S Wicker, Mark Peakman, Chantal Mathieu
AIMS/HYPOTHESIS: Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual's clinical course and treatment response will have important clinical and research implications. Our aim was to explore type 1 diabetes heterogeneity, as assessed by clinical characteristics, autoantibodies, beta cell function and glycaemic outcomes, during the first 12 months from diagnosis, and how it relates to age at diagnosis. METHODS: Data were collected from the large INNODIA cohort of individuals (aged 1...
March 22, 2024: Diabetologia
https://read.qxmd.com/read/38512414/differential-cpg-methylation-at-nnat-in-the-early-establishment-of-beta-cell-heterogeneity
#2
JOURNAL ARTICLE
Vanessa Yu, Fiona Yong, Angellica Marta, Sanjay Khadayate, Adrien Osakwe, Supriyo Bhattacharya, Sneha S Varghese, Pauline Chabosseau, Sayed M Tabibi, Keran Chen, Eleni Georgiadou, Nazia Parveen, Mara Suleiman, Zoe Stamoulis, Lorella Marselli, Carmela De Luca, Marta Tesi, Giada Ostinelli, Luis Delgadillo-Silva, Xiwei Wu, Yuki Hatanaka, Alex Montoya, James Elliott, Bhavik Patel, Nikita Demchenko, Chad Whilding, Petra Hajkova, Pavel Shliaha, Holger Kramer, Yusuf Ali, Piero Marchetti, Robert Sladek, Sangeeta Dhawan, Dominic J Withers, Guy A Rutter, Steven J Millership
AIMS/HYPOTHESIS: Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly connected 'hub' cells, important for the propagation of intercellular Ca2+ waves. Functional subpopulations have also been demonstrated in human beta cells, with an altered subtype distribution apparent in type 2 diabetes. At present, the molecular mechanisms through which beta cell hierarchy is established are poorly understood...
March 21, 2024: Diabetologia
https://read.qxmd.com/read/38509341/effectiveness-and-safety-of-empagliflozin-final-results-from-the-emprise-study
#3
JOURNAL ARTICLE
Phyo T Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J Wexler, Brendan M Everett, Robert J Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M Paik, Elisabetta Patorno
AIMS/HYPOTHESIS: Limited evidence exists on the comparative safety and effectiveness of empagliflozin against alternative glucose-lowering medications in individuals with type 2 diabetes with the broad spectrum of cardiovascular risk. The EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) cohort study was designed to monitor the safety and effectiveness of empagliflozin periodically for a period of 5 years with data collection from electronic healthcare databases. METHODS: We identified individuals ≥18 years old with type 2 diabetes who initiated empagliflozin or dipeptidyl peptidase-4 inhibitors (DPP-4i) from 2014 to 2019 using US Medicare and commercial claims databases...
March 21, 2024: Diabetologia
https://read.qxmd.com/read/38503901/ck2-activity-is-crucial-for-proper-glucagon-expression
#4
JOURNAL ARTICLE
Emmanuel Ampofo, Mandy Pack, Selina Wrublewsky, Anne S Boewe, Aliya F Spigelman, Hanna Koch, Patrick E MacDonald, Matthias W Laschke, Mathias Montenarh, Claudia Götz
AIMS/HYPOTHESIS: Protein kinase CK2 acts as a negative regulator of insulin expression in pancreatic beta cells. This action is mainly mediated by phosphorylation of the transcription factor pancreatic and duodenal homeobox protein 1 (PDX1). In pancreatic alpha cells, PDX1 acts in a reciprocal fashion on glucagon (GCG) expression. Therefore, we hypothesised that CK2 might positively regulate GCG expression in pancreatic alpha cells. METHODS: We suppressed CK2 kinase activity in αTC1 cells by two pharmacological inhibitors and by the CRISPR/Cas9 technique...
March 20, 2024: Diabetologia
https://read.qxmd.com/read/38502241/associations-between-daily-step-count-classifications-and-continuous-glucose-monitoring-metrics-in-adults-with-type-1-diabetes-analysis-of-the-type-1-diabetes-exercise-initiative-t1dexi-cohort
#5
JOURNAL ARTICLE
Lauren V Turner, Martin Chase Marak, Robin L Gal, Peter Calhoun, Zoey Li, Peter G Jacobs, Mark A Clements, Corby K Martin, Francis J Doyle, Susana R Patton, Jessica R Castle, Melanie B Gillingham, Roy W Beck, Michael R Rickels, Michael C Riddell
AIMS/HYPOTHESIS: Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence of daily step counts on continuous glucose monitoring (CGM) metrics are unclear. This analysis used the Type 1 Diabetes Exercise Initiative (T1DEXI) dataset to investigate the effect of daily step count on CGM-based metrics. METHODS: In a 4 week free-living observational study of adults with type 1 diabetes, with available CGM and step count data, we categorised participants into three groups-below (<7000), meeting (7000-10,000) or exceeding (>10,000) the daily step count goal-to determine if step count category influenced CGM metrics, including per cent time in range (TIR: 3...
March 19, 2024: Diabetologia
https://read.qxmd.com/read/38502240/no-association-between-long-chain-n-3-fatty-acid-intake-during-pregnancy-and-risk-of-type-1-diabetes-in-offspring-in-two-large-scandinavian-pregnancy-cohorts
#6
JOURNAL ARTICLE
Nicolai A Lund-Blix, Anne A Bjerregaard, German Tapia, Ketil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R Njølstad, Sjurdur F Olsen, Lars C Stene
AIMS/HYPOTHESIS: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children. METHODS: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires...
March 19, 2024: Diabetologia
https://read.qxmd.com/read/38498180/up-front
#7
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2024: Diabetologia
https://read.qxmd.com/read/38489029/circulating-small-extracellular-vesicles-mediate-vascular-hyperpermeability-in-diabetes
#8
JOURNAL ARTICLE
Dakota Gustafson, Peter V DiStefano, Xue Fan Wang, Ruilin Wu, Siavash Ghaffari, Crizza Ching, Kumaragurubaran Rathnakumar, Faisal Alibhai, Michal Syonov, Jessica Fitzpatrick, Emilie Boudreau, Cori Lau, Natalie Galant, Mansoor Husain, Ren-Ke Li, Warren L Lee, Rulan S Parekh, Philippe P Monnier, Jason E Fish
AIMS/HYPOTHESIS: A hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction of the cerebrovascular endothelium and the subsequent development of associated cognitive impairment. The present study tested the hypothesis that during type 2 diabetes circulating small extracellular vesicles (sEVs) exhibit phenotypic changes that facilitate pathogenic disruption of the vascular barrier. METHODS: sEVs isolated from the plasma of a mouse model of type 2 diabetes and from diabetic human individuals were characterised for their ability to disrupt the endothelial cell (EC) barrier...
March 15, 2024: Diabetologia
https://read.qxmd.com/read/38483543/a-ketone-monoester-drink-reduces-postprandial-blood-glucose-concentrations-in-adults-with-type-2-diabetes-a-randomised-controlled-trial
#9
JOURNAL ARTICLE
Alistair J Monteyne, Kaja Falkenhain, Gráinne Whelehan, Helena Neudorf, Doaa R Abdelrahman, Andrew J Murton, Benjamin T Wall, Francis B Stephens, Jonathan P Little
AIMS/HYPOTHESIS: The aim of the present study was to conduct a randomised, placebo-controlled, double-blind, crossover trial to determine whether pre-meal ketone monoester ingestion reduces postprandial glucose concentrations in individuals with type 2 diabetes. METHODS: In this double-blind, placebo-controlled, crossover design study, ten participants with type 2 diabetes (age 59±1.7 years, 50% female, BMI 32±1 kg/m2 , HbA1c 54±2 mmol/mol [7.1±0...
March 14, 2024: Diabetologia
https://read.qxmd.com/read/38478050/relationship-of-device-measured-physical-activity-type-and-posture-with-cardiometabolic-health-markers-pooled-dose-response-associations-from-the-prospective-physical-activity-sitting-and-sleep-consortium
#10
JOURNAL ARTICLE
Matthew N Ahmadi, Joanna M Blodgett, Andrew J Atkin, Hsiu-Wen Chan, Borja Del Pozo Cruz, Kristin Suorsa, Esmee A Bakker, Richard M Pulsford, Gregore I Mielke, Peter J Johansson, Pasan Hettiarachchi, Dick H J Thijssen, Sari Stenholm, Gita D Mishra, Armando Teixeira-Pinot, Vegar Rangul, Lauren B Sherar, Ulf Ekelund, Alun D Hughes, I-Min Lee, Andreas Holtermann, Annemarie Koster, Mark Hamer, Emmanuel Stamatakis
AIMS/HYPOTHESIS: The aim of this study was to examine the dose-response associations of device-measured physical activity types and postures (sitting and standing time) with cardiometabolic health. METHODS: We conducted an individual participant harmonised meta-analysis of 12,095 adults (mean ± SD age 54.5±9.6 years; female participants 54.8%) from six cohorts with thigh-worn accelerometry data from the Prospective Physical Activity, Sitting and Sleep (ProPASS) Consortium...
March 13, 2024: Diabetologia
https://read.qxmd.com/read/38431705/glucose-tolerance-and-insulin-resistance-sensitivity-associate-with-retinal-layer-characteristics-the-life-adult-study
#11
JOURNAL ARTICLE
Franziska G Rauscher, Tobias Elze, Mike Francke, M Elena Martinez-Perez, Yangjiani Li, Kerstin Wirkner, Anke Tönjes, Christoph Engel, Joachim Thiery, Matthias Blüher, Michael Stumvoll, Toralf Kirsten, Markus Loeffler, Thomas Ebert, Mengyu Wang
AIMS/HYPOTHESIS: As the prevalence of insulin resistance and glucose intolerance is increasing throughout the world, diabetes-induced eye diseases are a global health burden. We aim to identify distinct optical bands which are closely related to insulin and glucose metabolism, using non-invasive, high-resolution spectral domain optical coherence tomography (SD-OCT) in a large, population-based dataset. METHODS: The LIFE-Adult-Study randomly selected 10,000 participants from the population registry of Leipzig, Germany...
March 2, 2024: Diabetologia
https://read.qxmd.com/read/38427076/metabolic-effect-of-adrenaline-infusion-in-people-with-type-1-diabetes-and-healthy-individuals
#12
JOURNAL ARTICLE
Rui She, Tommi Suvitaival, Henrik U Andersen, Eva Hommel, Kirsten Nørgaard, Jørgen F P Wojtaszewski, Cristina Legido-Quigley, Ulrik Pedersen-Bjergaard
AIMS/HYPOTHESIS: As a result of early loss of the glucagon response, adrenaline is the primary counter-regulatory hormone in type 1 diabetes. Diminished adrenaline responses to hypoglycaemia due to counter-regulatory failure are common in type 1 diabetes, and are probably induced by exposure to recurrent hypoglycaemia, however, the metabolic effects of adrenaline have received less research attention, and also there is conflicting evidence regarding adrenaline sensitivity in type 1 diabetes...
March 1, 2024: Diabetologia
https://read.qxmd.com/read/38427075/critical-comments-regarding-the-assessment-of-quality-of-life-and-the-clinical-impact-of-the-power2dm-intervention-reply-to-pouwer-f-desch%C3%A3%C2%AAnes-ss-letter
#13
LETTER
Merel M Ruissen, Ewout W Steyerberg, Sasja D Huisman, Albert A de Graaf, Eelco J P de Koning, Javier Delgado-Lista, Jacob K Sont
No abstract text is available yet for this article.
March 1, 2024: Diabetologia
https://read.qxmd.com/read/38427074/critical-comments-regarding-the-assessment-of-quality-of-life-and-the-clinical-impact-of-the-power2dm-intervention
#14
LETTER
Frans Pouwer, Sonya Deschênes
No abstract text is available yet for this article.
March 1, 2024: Diabetologia
https://read.qxmd.com/read/38413438/elevated-itga1-levels-in-type-2-diabetes-implications-for-cardiac-function-impairment
#15
JOURNAL ARTICLE
Mengqi Su, Yilin Hou, Sidong Cai, Wenpeng Li, Yinxia Wei, Run Wang, Min Wu, Mingya Liu, Junlei Chang, Kelaier Yang, Kaihang Yiu, Cong Chen
AIMS/HYPOTHESIS: Type 2 diabetes mellitus is known to contribute to the development of heart failure with preserved ejection fraction (HFpEF). However, identifying HFpEF in individuals with type 2 diabetes early on is often challenging due to a limited array of biomarkers. This study aims to investigate specific biomarkers associated with the progression of HFpEF in individuals with type 2 diabetes, for the purpose of enabling early detection and more effective management strategies. METHODS: Blood samples were collected from individuals with type 2 diabetes, both with and without HFpEF, for proteomic analysis...
February 27, 2024: Diabetologia
https://read.qxmd.com/read/38413437/circulating-metabolomic-markers-linking-diabetic-kidney-disease-and-incident-cardiovascular-disease-in-type-2-diabetes-analyses-from-the-hong-kong-diabetes-biobank
#16
JOURNAL ARTICLE
Qiao Jin, Eric S H Lau, Andrea O Luk, Claudia H T Tam, Risa Ozaki, Cadmon K P Lim, Hongjiang Wu, Elaine Y K Chow, Alice P S Kong, Heung Man Lee, Baoqi Fan, Alex C W Ng, Guozhi Jiang, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y Leung, Man-Wo Tsang, Elaine Y N Cheung, Grace Kam, Ip Tim Lau, June K Li, Vincent T F Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Weichuan Yu, Stephen K W Tsui, Brian Tomlinson, Yu Huang, Hui-Yao Lan, Cheuk Chun Szeto, Wing Yee So, Alicia J Jenkins, Erik Fung, Mirthe Muilwijk, Marieke T Blom, Leen M 't Hart, Juliana C N Chan, Ronald C W Ma
AIMS/HYPOTHESIS: The aim of this study was to describe the metabolome in diabetic kidney disease (DKD) and its association with incident CVD in type 2 diabetes, and identify prognostic biomarkers. METHODS: From a prospective cohort of individuals with type 2 diabetes, baseline sera (N=1991) were quantified for 170 metabolites using NMR spectroscopy with median 5.2 years of follow-up. Associations of chronic kidney disease (CKD, eGFR<60 ml/min per 1.73 m2 ) or severely increased albuminuria with each metabolite were examined using linear regression, adjusted for confounders and multiplicity...
February 27, 2024: Diabetologia
https://read.qxmd.com/read/38413436/dysregulated-24-h-melatonin-secretion-associated-with-intrinsically-photosensitive-retinal-ganglion-cell-function-in-diabetic-retinopathy-a-cross-sectional-study
#17
JOURNAL ARTICLE
Sirimon Reutrakul, Jason C Park, J Jason McAnany, Felix Y Chau, Kirstie K Danielson, Bharati Prasad, Andrew Cross, Stephanie Sintetas, Julie Law, Silvana Pannain, Sarida Pratuangtham, Eve Van Cauter, Erin C Hanlon
AIMS/HYPOTHESIS: The aim of this study was to explore whether diabetic retinopathy is associated with alterations of the circadian system, and to examine the role of reduced intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS: Participants with type 2 diabetes, with diabetic retinopathy (n=14) and without diabetic retinopathy (n=9) underwent 24 h blood sampling for melatonin and cortisol under controlled laboratory conditions. ipRGC function was inferred from the post-illumination pupil response (PIPR)...
February 27, 2024: Diabetologia
https://read.qxmd.com/read/38409440/cardiovascular-risk-management-among-individuals-with-type-2-diabetes-and-severe-mental-illness-a-cohort-study
#18
JOURNAL ARTICLE
Jonne G Ter Braake, Kelly J Fleetwood, Rimke C Vos, Luke Blackbourn, Stuart J McGurnaghan, Sarah H Wild, Caroline A Jackson
AIMS/HYPOTHESIS: The aim of this study was to compare cardiovascular risk management among people with type 2 diabetes according to severe mental illness (SMI) status. METHODS: We used linked electronic data to perform a retrospective cohort study of adults diagnosed with type 2 diabetes in Scotland between 2004 and 2020, ascertaining their history of SMI from hospital admission records. We compared total cholesterol, systolic BP and HbA1c target level achievement 1 year after diabetes diagnosis, and receipt of a statin prescription at diagnosis and 1 year thereafter, by SMI status using logistic regression, adjusting for sociodemographic factors and clinical history...
February 26, 2024: Diabetologia
https://read.qxmd.com/read/38409439/interferons-are-key-cytokines-acting-on-pancreatic-islets-in-type-1-diabetes
#19
JOURNAL ARTICLE
Alexandra Coomans de Brachène, Maria Ines Alvelos, Florian Szymczak, Priscila L Zimath, Angela Castela, Bianca Marmontel de Souza, Arturo Roca Rivada, Sandra Marín-Cañas, Xiaoyan Yi, Anne Op de Beeck, Noel G Morgan, Sebastian Sonntag, Sayro Jawurek, Alexandra C Title, Burcak Yesildag, François Pattou, Julie Kerr-Conte, Eduard Montanya, Montserrat Nacher, Lorella Marselli, Piero Marchetti, Sarah J Richardson, Decio L Eizirik
AIMS/HYPOTHESIS: The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and therefore represent attractive therapeutic targets to protect beta cells. However, the specific role of each of these cytokines individually on pancreatic beta cells remains unknown. METHODS: We used deep RNA-seq analysis, followed by extensive confirmation experiments based on reverse transcription-quantitative PCR (RT-qPCR), western blot, histology and use of siRNAs, to characterise the response of human pancreatic beta cells to each cytokine individually and compared the signatures obtained with those present in islets of individuals affected by type 1 diabetes...
February 26, 2024: Diabetologia
https://read.qxmd.com/read/38409438/incidence-trend-of-type-2-diabetes-from-2012-to-2021-in-germany-an-analysis-of-health-claims-data-of-11-million-statutorily-insured-people
#20
JOURNAL ARTICLE
Carolin T Lehner, Marian Eberl, Ewan Donnachie, Luana F Tanaka, Gunther Schauberger, Florian Schederecker, Sebastian Himmler, Leonie Sundmacher, Stefanie J Klug
AIMS/HYPOTHESIS: The aim of the study is to describe the time trend of type 2 diabetes incidence in the largest state of Germany, Bavaria, from 2012 to 2021, and to compare the incidence rates during the pandemic period (2020-2021) to the pre-pandemic period (2012-2019). METHODS: This secondary data analysis uses health claims data provided by the Bavarian Association of Statutory Health Insurance Physicians (KVB), covering approximately 11 million insurees, accounting for 85% of the total population of Bavaria, Germany...
February 26, 2024: Diabetologia
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