Qiao Jin, Eric S H Lau, Andrea O Luk, Claudia H T Tam, Risa Ozaki, Cadmon K P Lim, Hongjiang Wu, Elaine Y K Chow, Alice P S Kong, Heung Man Lee, Baoqi Fan, Alex C W Ng, Guozhi Jiang, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y Leung, Man-Wo Tsang, Elaine Y N Cheung, Grace Kam, Ip Tim Lau, June K Li, Vincent T F Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Weichuan Yu, Stephen K W Tsui, Brian Tomlinson, Yu Huang, Hui-Yao Lan, Cheuk Chun Szeto, Wing Yee So, Alicia J Jenkins, Erik Fung, Mirthe Muilwijk, Marieke T Blom, Leen M 't Hart, Juliana C N Chan, Ronald C W Ma
AIMS/HYPOTHESIS: The aim of this study was to describe the metabolome in diabetic kidney disease (DKD) and its association with incident CVD in type 2 diabetes, and identify prognostic biomarkers. METHODS: From a prospective cohort of individuals with type 2 diabetes, baseline sera (N=1991) were quantified for 170 metabolites using NMR spectroscopy with median 5.2 years of follow-up. Associations of chronic kidney disease (CKD, eGFR<60 ml/min per 1.73 m2 ) or severely increased albuminuria with each metabolite were examined using linear regression, adjusted for confounders and multiplicity...
February 27, 2024: Diabetologia