journal
https://read.qxmd.com/read/38639876/continuous-glucose-monitoring-with-structured-education-in-adults-with-type-2-diabetes-managed-by-multiple-daily-insulin-injections-a-multicentre-randomised-controlled-trial
#1
JOURNAL ARTICLE
Ji Yoon Kim, Sang-Man Jin, Kang Hee Sim, Bo-Yeon Kim, Jae Hyoung Cho, Jun Sung Moon, Soo Lim, Eun Seok Kang, Cheol-Young Park, Sin Gon Kim, Jae Hyeon Kim
AIMS/HYPOTHESIS: The aim of this study was to compare the effectiveness of stand-alone intermittently scanned continuous glucose monitoring (isCGM) with or without a structured education programme and blood glucose monitoring (BGM) in adults with type 2 diabetes on multiple daily insulin injections (MDI). METHODS: In this 24 week randomised open-label multicentre trial, adults with type 2 diabetes on intensive insulin therapy with HbA1c levels of 58-108 mmol/mol (7...
April 19, 2024: Diabetologia
https://read.qxmd.com/read/38634887/comparison-between-a-tubeless-on-body-automated-insulin-delivery-system-and-a-tubeless-on-body-sensor-augmented-pump-in-type-1-diabetes-a-multicentre-randomised-controlled-trial
#2
JOURNAL ARTICLE
Ji Yoon Kim, Sang-Man Jin, Eun Seok Kang, Soo Heon Kwak, Yeoree Yang, Jee Hee Yoo, Jae Hyun Bae, Jun Sung Moon, Chang Hee Jung, Ji Cheol Bae, Sunghwan Suh, Sun Joon Moon, Sun Ok Song, Suk Chon, Jae Hyeon Kim
AIMS/HYPOTHESIS: This study compares the efficacy and safety of a tubeless, on-body automated insulin delivery (AID) system with that of a tubeless, on-body sensor-augmented pump (SAP). METHODS: This multicentre, parallel-group, RCT was conducted at 13 tertiary medical centres in South Korea. Adults aged 19-69 years with type 1 diabetes who had HbA1c levels of <85.8 mmol/mol (<10.0%) were eligible. The participants were assigned at a 1:1 ratio to receive a tubeless, on-body AID system (intervention group) or a tubeless, on-body SAP (control group) for 12 weeks...
April 18, 2024: Diabetologia
https://read.qxmd.com/read/38630142/a-3d-atlas-of-the-human-developing-pancreas-to-explore-progenitor-proliferation-and-differentiation
#3
JOURNAL ARTICLE
Adrian Villalba, Yorick Gitton, Megumi Inoue, Virginie Aiello, Raphaël Blain, Maryne Toupin, Séverine Mazaud-Guittot, Latif Rachdi, Henrik Semb, Alain Chédotal, Raphaël Scharfmann
AIMS/HYPOTHESIS: Rodent pancreas development has been described in great detail. On the other hand, there are still gaps in our understanding of the developmental trajectories of pancreatic cells during human ontogenesis. Here, our aim was to map the spatial and chronological dynamics of human pancreatic cell differentiation and proliferation by using 3D imaging of cleared human embryonic and fetal pancreases. METHODS: We combined tissue clearing with light-sheet fluorescence imaging in human embryonic and fetal pancreases during the first trimester of pregnancy...
April 17, 2024: Diabetologia
https://read.qxmd.com/read/38625583/trajectories-of-clinical-characteristics-complications-and-treatment-choices-in-data-driven-subgroups-of-type-2-diabetes
#4
JOURNAL ARTICLE
Xinyu Li, Louise A Donnelly, Roderick C Slieker, Joline W J Beulens, Leen M 't Hart, Petra J M Elders, Ewan R Pearson, Anoukh van Giessen, Jose Leal, Talitha Feenstra
AIMS/HYPOTHESIS: This study aimed to explore the added value of subgroups that categorise individuals with type 2 diabetes by k-means clustering for two primary care registries (the Netherlands and Scotland), inspired by Ahlqvist's novel diabetes subgroups and previously analysed by Slieker et al. METHODS: We used two Dutch and Scottish diabetes cohorts (N=3054 and 6145; median follow-up=11.2 and 12.3 years, respectively) and defined five subgroups by k-means clustering with age at baseline, BMI, HbA1c , HDL-cholesterol and C-peptide...
April 16, 2024: Diabetologia
https://read.qxmd.com/read/38625582/prevention-and-treatment-of-ischaemic-and-haemorrhagic-stroke-in-people-with-diabetes-mellitus-a-focus-on-glucose-control-and-comorbidities
#5
REVIEW
Simona Sacco, Matteo Foschi, Raffaele Ornello, Federico De Santis, Riccardo Pofi, Michele Romoli
Diabetes mellitus is a significant risk factor for both ischaemic and haemorrhagic stroke, affecting up to a third of individuals with cerebrovascular diseases. Beyond being a risk factor for stroke, diabetes and hyperglycaemia have a negative impact on outcomes after ischaemic and haemorrhagic stroke. Hyperglycaemia during the acute ischaemic stroke phase is associated with a higher risk of haemorrhagic transformation and poor functional outcome, with evidence in favour of early intervention to limit and manage severe hyperglycaemia...
April 16, 2024: Diabetologia
https://read.qxmd.com/read/38613667/subcutaneously-administered-tirzepatide-vs-semaglutide-for-adults-with-type-2-diabetes-a-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials
#6
REVIEW
Thomas Karagiannis, Konstantinos Malandris, Ioannis Avgerinos, Athina Stamati, Panagiota Kakotrichi, Aris Liakos, Despoina Vasilakou, Nikolaos Kakaletsis, Apostolos Tsapas, Eleni Bekiari
AIMS/HYPOTHESIS: We conducted a systematic review and network meta-analysis to compare the efficacy and safety of s.c. administered tirzepatide vs s.c. administered semaglutide for adults of both sexes with type 2 diabetes mellitus. METHODS: We searched PubMed and Cochrane up to 11 November 2023 for RCTs with an intervention duration of at least 12 weeks assessing s.c. tirzepatide at maintenance doses of 5 mg, 10 mg or 15 mg once weekly, or s.c. semaglutide at maintenance doses of 0...
April 13, 2024: Diabetologia
https://read.qxmd.com/read/38613666/gestational-age-at-birth-and-type-1-diabetes-in-childhood-and-young-adulthood-a-nationwide-register-study-in-finland-norway-and-sweden
#7
JOURNAL ARTICLE
Johanna Metsälä, Kari Risnes, Martina Persson, Riitta Veijola, Anna Pulakka, Katriina Heikkilä, Suvi Alenius, Mika Gissler, Signe Opdahl, Sven Sandin, Eero Kajantie
AIMS/HYPOTHESIS: Children and adults born preterm have an increased risk of type 1 diabetes. However, there is limited information on risk patterns across the full range of gestational ages, especially after extremely preterm birth (23-27 weeks of gestation). We investigated the risk of type 1 diabetes in childhood and young adulthood across the full range of length of gestation at birth. METHODS: Data were obtained from national registers in Finland, Norway and Sweden...
April 13, 2024: Diabetologia
https://read.qxmd.com/read/38584181/can-the-introduction-of-a-12-lead-ecg-help-reduce-mortality-in-those-presenting-with-foot-ulceration-to-multidisciplinary-diabetic-foot-clinics-an-observational-evaluation-of-a-real-world-implementation-pilot-in-england
#8
JOURNAL ARTICLE
Jonathan Valabhji, Naomi Holman, Nicholas Collins, Robert J Young, Paul Chadwick, Adam Robinson, Rahul Nayar, Satyan Rajbhandari, David V Coppini, Marie-France Kong, Simon Ashwell, Ananth Nayak, Sanjeev Mehta, Chris Manu, Michael Edmonds, Catherine Gooday, Ketan Dhatariya
AIMS/HYPOTHESIS: The risk of dying within 2 years of presentation with diabetic foot ulceration is over six times the risk of amputation, with CVD the major contributor. Using an observational evaluation of a real-world implementation pilot, we aimed to assess whether for those presenting with diabetic foot ulceration in England, introducing a 12-lead ECG into routine care followed by appropriate clinical action was associated with reduced mortality. METHODS: Between July 2014 and December 2017, ten multidisciplinary diabetic foot services in England participated in a pilot project introducing 12-lead ECGs for new attendees with foot ulceration...
April 8, 2024: Diabetologia
https://read.qxmd.com/read/38584180/risk-of-diabetic-retinopathy-and-diabetic-macular-oedema-with-sodium-glucose-cotransporter-2-inhibitors-and-glucagon-like-peptide-1-receptor-agonists-in-type-2-diabetes-a-real-world-data-study-from-a-global-federated-database
#9
JOURNAL ARTICLE
Aikaterini Eleftheriadou, David Riley, Sizheng S Zhao, Philip Austin, Gema Hernández, Gregory Y H Lip, Timothy L Jackson, John P H Wilding, Uazman Alam
AIMS/HYPOTHESIS: A protective role of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP1-ra) in the development of diabetic retinopathy and diabetic macular oedema has been described in some recent studies, which may extend beyond glycaemic control. We aimed to review the clinical impact of SGLT2i and GLP1-ra therapy on the risk of diabetic retinopathy and diabetic macular oedema in individuals with type 2 diabetes taking insulin. METHODS: This is a retrospective cohort analysis of approximately two million people with type 2 diabetes receiving insulin across 97 healthcare organisations using a global federated health research network (TriNetX, Cambridge, USA)...
April 8, 2024: Diabetologia
https://read.qxmd.com/read/38580845/an-unclear-role-for-the-glp-1-metabolite-glp-1-9-36-in-human-islet-physiology
#10
LETTER
Aleksey Matveyenko, Adrian Vella
No abstract text is available yet for this article.
April 6, 2024: Diabetologia
https://read.qxmd.com/read/38578451/correction-to-occurrence-of-corneal-sub-epithelial-microneuromas-and-axonal-swelling-in-people-with-diabetes-with-and-without-painful-diabetic-neuropathy
#11
Eva Sierra-Silvestre, Ricardo J Andrade, Luisa H Colorado, Katie Edwards, Michel W Coppieters
No abstract text is available yet for this article.
April 5, 2024: Diabetologia
https://read.qxmd.com/read/38578450/an-unclear-role-for-the-glp-1-metabolite-glp-1-9-36-in-human-islet-physiology-reply-to-matveyenko-a-vella-a-letter
#12
LETTER
Nikhil R Gandasi, Patrik Rorsman
No abstract text is available yet for this article.
April 5, 2024: Diabetologia
https://read.qxmd.com/read/38568252/threshold-of-hyperglycaemia-associated-with-mortality-in-critically-ill-patients-a-multicentre-prospective-observational-study-using-continuous-glucose-monitoring
#13
JOURNAL ARTICLE
Yaxin Wang, Siwan Li, Jingyi Lu, Kaixuan Feng, Xiaoli Huang, Fangbao Hu, Menghan Sun, Yan Zou, Yingchuan Li, Weifeng Huang, Jian Zhou
AIMS/HYPOTHESIS: Continuous glucose monitoring (CGM) provides comprehensive information on the exposure to dysglycaemia. This study aimed to investigate the threshold of hyperglycaemia related to mortality risk in critically ill patients using CGM technology. METHODS: A total of 293 adult critically ill patients admitted to intensive care units of five medical centres were prospectively included between May 2020 and November 2021. Participants wore intermittently scanned CGM for a median of 12...
April 3, 2024: Diabetologia
https://read.qxmd.com/read/38561463/impact-of-the-timing-of-metformin-administration-on-glycaemic-and-glucagon-like-peptide-1-responses-to-intraduodenal-glucose-infusion-in-type-2-diabetes-a-double-blind-randomised-placebo-controlled-crossover-study
#14
JOURNAL ARTICLE
Cong Xie, Peter Iroga, Michelle J Bound, Jacqueline Grivell, Weikun Huang, Karen L Jones, Michael Horowitz, Christopher K Rayner, Tongzhi Wu
AIMS/HYPOTHESIS: Metformin lowers postprandial glycaemic excursions in individuals with type 2 diabetes by modulating gastrointestinal function, including the stimulation of glucagon-like peptide-1 (GLP-1). The impact of varying the timing of metformin administration on postprandial glucose metabolism is poorly defined. We evaluated the effects of metformin, administered at different intervals before an intraduodenal glucose infusion, on the subsequent glycaemic, insulinaemic and GLP-1 responses in metformin-treated type 2 diabetes...
April 1, 2024: Diabetologia
https://read.qxmd.com/read/38546822/transcutaneous-vagal-nerve-stimulation-for-treating-gastrointestinal-symptoms-in-individuals-with-diabetes-a-randomised-double-blind-sham-controlled-multicentre-trial
#15
JOURNAL ARTICLE
Ditte S Kornum, Davide Bertoli, Huda Kufaishi, Anne-Marie Wegeberg, Tina Okdahl, Esben B Mark, Katrine L Høyer, Jens B Frøkjær, Birgitte Brock, Klaus Krogh, Christian S Hansen, Filip K Knop, Christina Brock, Asbjørn M Drewes
AIMS/HYPOTHESIS: Diabetic gastroenteropathy frequently causes debilitating gastrointestinal symptoms. Previous uncontrolled studies have shown that transcutaneous vagal nerve stimulation (tVNS) may improve gastrointestinal symptoms. To investigate the effect of cervical tVNS in individuals with diabetes suffering from autonomic neuropathy and gastrointestinal symptoms, we conducted a randomised, sham-controlled, double-blind (participants and investigators were blinded to the allocated treatment) study...
March 28, 2024: Diabetologia
https://read.qxmd.com/read/38546821/integration-of-a-fasting-mimicking-diet-programme-in-primary-care-for-type-2-diabetes-reduces-the-need-for-medication-and-improves-glycaemic-control-a-12-month-randomised-controlled-trial
#16
JOURNAL ARTICLE
Elske L van den Burg, Marjolein P Schoonakker, Petra G van Peet, Elske M van den Akker-van Marle, Hildo J Lamb, Valter D Longo, Mattijs E Numans, Hanno Pijl
AIMS/HYPOTHESIS: The aim of this study was to evaluate the impact on metabolic control of periodic use of a 5-day fasting-mimicking diet (FMD) programme as an adjunct to usual care in people with type 2 diabetes under regular primary care surveillance. METHODS: In this randomised, controlled, assessor-blinded trial, people with type 2 diabetes using metformin as the only glucose-lowering drug and/or diet for glycaemic control were randomised to receive 5-day cycles of an FMD monthly as an adjunct to regular care by their general practitioner or to receive regular care only...
March 28, 2024: Diabetologia
https://read.qxmd.com/read/38517484/the-innodia-type-1-diabetes-natural-history-study-a-european-cohort-of-newly-diagnosed-children-adolescents-and-adults
#17
JOURNAL ARTICLE
M Loredana Marcovecchio, A Emile J Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A Todd, Bart Van der Schueren, Linda S Wicker, Mark Peakman, Chantal Mathieu
AIMS/HYPOTHESIS: Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual's clinical course and treatment response will have important clinical and research implications. Our aim was to explore type 1 diabetes heterogeneity, as assessed by clinical characteristics, autoantibodies, beta cell function and glycaemic outcomes, during the first 12 months from diagnosis, and how it relates to age at diagnosis. METHODS: Data were collected from the large INNODIA cohort of individuals (aged 1...
March 22, 2024: Diabetologia
https://read.qxmd.com/read/38512414/differential-cpg-methylation-at-nnat-in-the-early-establishment-of-beta-cell-heterogeneity
#18
JOURNAL ARTICLE
Vanessa Yu, Fiona Yong, Angellica Marta, Sanjay Khadayate, Adrien Osakwe, Supriyo Bhattacharya, Sneha S Varghese, Pauline Chabosseau, Sayed M Tabibi, Keran Chen, Eleni Georgiadou, Nazia Parveen, Mara Suleiman, Zoe Stamoulis, Lorella Marselli, Carmela De Luca, Marta Tesi, Giada Ostinelli, Luis Delgadillo-Silva, Xiwei Wu, Yuki Hatanaka, Alex Montoya, James Elliott, Bhavik Patel, Nikita Demchenko, Chad Whilding, Petra Hajkova, Pavel Shliaha, Holger Kramer, Yusuf Ali, Piero Marchetti, Robert Sladek, Sangeeta Dhawan, Dominic J Withers, Guy A Rutter, Steven J Millership
AIMS/HYPOTHESIS: Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly connected 'hub' cells, important for the propagation of intercellular Ca2+ waves. Functional subpopulations have also been demonstrated in human beta cells, with an altered subtype distribution apparent in type 2 diabetes. At present, the molecular mechanisms through which beta cell hierarchy is established are poorly understood...
March 21, 2024: Diabetologia
https://read.qxmd.com/read/38509341/effectiveness-and-safety-of-empagliflozin-final-results-from-the-emprise-study
#19
JOURNAL ARTICLE
Phyo T Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J Wexler, Brendan M Everett, Robert J Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M Paik, Elisabetta Patorno
AIMS/HYPOTHESIS: Limited evidence exists on the comparative safety and effectiveness of empagliflozin against alternative glucose-lowering medications in individuals with type 2 diabetes with the broad spectrum of cardiovascular risk. The EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) cohort study was designed to monitor the safety and effectiveness of empagliflozin periodically for a period of 5 years with data collection from electronic healthcare databases. METHODS: We identified individuals ≥18 years old with type 2 diabetes who initiated empagliflozin or dipeptidyl peptidase-4 inhibitors (DPP-4i) from 2014 to 2019 using US Medicare and commercial claims databases...
March 21, 2024: Diabetologia
https://read.qxmd.com/read/38503901/ck2-activity-is-crucial-for-proper-glucagon-expression
#20
JOURNAL ARTICLE
Emmanuel Ampofo, Mandy Pack, Selina Wrublewsky, Anne S Boewe, Aliya F Spigelman, Hanna Koch, Patrick E MacDonald, Matthias W Laschke, Mathias Montenarh, Claudia Götz
AIMS/HYPOTHESIS: Protein kinase CK2 acts as a negative regulator of insulin expression in pancreatic beta cells. This action is mainly mediated by phosphorylation of the transcription factor pancreatic and duodenal homeobox protein 1 (PDX1). In pancreatic alpha cells, PDX1 acts in a reciprocal fashion on glucagon (GCG) expression. Therefore, we hypothesised that CK2 might positively regulate GCG expression in pancreatic alpha cells. METHODS: We suppressed CK2 kinase activity in αTC1 cells by two pharmacological inhibitors and by the CRISPR/Cas9 technique...
March 20, 2024: Diabetologia
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