Zebrafish: a genetic model for vertebrate organogenesis and human disorders

Gabriele E Ackermann, Barry H Paw
Frontiers in Bioscience: a Journal and Virtual Library 2003 September 1, 8: d1227-53
Mutations may be tolerated without noticeable effect or may present with a specific phenotype that reveals information about the function of the mutated gene. This information is an inexhaustible source for understanding biology and let us ask particular questions about the molecular mechanisms of development, degeneration and disease. The zebrafish (Danio rerio) has been proven to be instrumental in the genetic analysis of spontaneous and induced mutations and has provided invaluable clues to the elucidation of complex molecular processes in vertebrate biology. Since completion of the two large-scale mutagenesis screens carried out at the Max-Planck Institute in Tuebingen and at the Massachusetts General Hospital in Boston, many of the recovered mutations have been cloned and the function of the mutated genes studied. Special interest laid in the analysis of mutations affecting structures and organ systems characteristic for vertebrates such as the notochord, neural crest, heart, vasculature, blood and kidney. This review updates our knowledge of heart, vessel, blood and kidney organogenesis in zebrafish and extrapolates our insights to human disorders by assessing common genetic pathways.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"