We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Zebrafish: a genetic model for vertebrate organogenesis and human disorders.
Frontiers in Bioscience : a Journal and Virtual Library 2003 September 2
Mutations may be tolerated without noticeable effect or may present with a specific phenotype that reveals information about the function of the mutated gene. This information is an inexhaustible source for understanding biology and let us ask particular questions about the molecular mechanisms of development, degeneration and disease. The zebrafish (Danio rerio) has been proven to be instrumental in the genetic analysis of spontaneous and induced mutations and has provided invaluable clues to the elucidation of complex molecular processes in vertebrate biology. Since completion of the two large-scale mutagenesis screens carried out at the Max-Planck Institute in Tuebingen and at the Massachusetts General Hospital in Boston, many of the recovered mutations have been cloned and the function of the mutated genes studied. Special interest laid in the analysis of mutations affecting structures and organ systems characteristic for vertebrates such as the notochord, neural crest, heart, vasculature, blood and kidney. This review updates our knowledge of heart, vessel, blood and kidney organogenesis in zebrafish and extrapolates our insights to human disorders by assessing common genetic pathways.
Full text links
Related Resources
Trending Papers
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.Mayo Clinic Proceedings 2024 April
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app