M Di Domenico, D Scumaci, S Grasso, M Gaspari, A Curcio, A Oliva, F Ausania, C Di Nunzio, C Ricciardi, A C Santini, F A Rizzo, C Romano Carratelli, M Lamberti, D Conti, R La Montagna, V Tomei, V Malafoglia, V L Pascali, P Ricci, C Indolfi, F Costanzo, G Cuda
Brugada Syndrome (BS) is a polygenic inherited cardiac disease characterized by life-threatening arrhythmias and high incidence of sudden death. In this study, two-dimensional gel electrophoresis (2D-PAGE) coupled to mass spectrometry (LC-MS/MS) was used to investigate specific changes in the plasma proteome of BS patients and family members sharing the same gene mutation (SCN5AQ1118X), with the aim to identify novel disease biomarkers. Our data demonstrate that the levels of several proteins were significantly altered in BS patients compared with controls...
2013: Frontiers in Bioscience: a Journal and Virtual Library