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Case Reports
Journal Article
Cytokine abnormalities in a patient with eosinophilic fasciitis.
Annals of Allergy, Asthma & Immunology 2003 April
BACKGROUND: Eosinophilic fasciitis (EF) and peripheral eosinophilia are rare in children.
OBJECTIVE: To describe a case of EF in a 3-year-old child who presented with acute painless induration of her forearm.
METHODS: Cytokine profiles were obtained and compared with patients with atopic disease during the acute presentation and after treatment with low-dose prednisone.
RESULTS: The patient's serum showed elevation of transforming growth factor beta1 and interleukin-5, which improved after treatment with low-dose prednisone.
CONCLUSIONS: The case suggests that patients with EF have cytokine abnormalities similar to atopic patients, but with a striking elevation of transforming growth factor beta1. The responsiveness of the clinical symptoms and cytokine profile to low dose prednisone supports treatment with low dose immunosuppressive therapy in this disorder.
OBJECTIVE: To describe a case of EF in a 3-year-old child who presented with acute painless induration of her forearm.
METHODS: Cytokine profiles were obtained and compared with patients with atopic disease during the acute presentation and after treatment with low-dose prednisone.
RESULTS: The patient's serum showed elevation of transforming growth factor beta1 and interleukin-5, which improved after treatment with low-dose prednisone.
CONCLUSIONS: The case suggests that patients with EF have cytokine abnormalities similar to atopic patients, but with a striking elevation of transforming growth factor beta1. The responsiveness of the clinical symptoms and cytokine profile to low dose prednisone supports treatment with low dose immunosuppressive therapy in this disorder.
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