Melchior Chabannes, Marion Rabant, Carine El Sissy, Marie-Agnès Dragon-Durey, Paula Vieira Martins, Marie Sophie Meuleman, Alexandre Karras, David Buob, Frank Bridoux, Eric Daugas, Vincent Audard, Sophie Caillard, Jérôme Olagne, Christine Kandel, Sophie Ferlicot, Carole Philipponnet, Thomas Crepin, Eric Thervet, Didier Ducloux, Véronique Frémeaux-Bacchi, Sophie Chauvet
RATIONALE & OBJECTIVE: C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two distinct rare kidney diseases caused by dysregulation of the alternative complement pathway. Patients with C3G and concurrent kidney lesions of thrombotic microangiopathy (TMA) have been rarely reported. The objectives of this study were to characterize the clinical features and underlying immunological abnormalities in these patients. STUDY DESIGN: Case series...
April 13, 2023: American Journal of Kidney Diseases