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American Journal of Kidney Diseases

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https://read.qxmd.com/read/31101403/safety-and-effectiveness-of-bexagliflozin-in-patients-with-type-2-diabetes-mellitus-and-stage-3a-3b-ckd
#1
Andrew S Allegretti, Wenbin Zhang, Wenjiong Zhou, Tara K Thurber, Scott P Rigby, Cynthia Bowman-Stroud, Carlos Trescoli, Pierre Serusclat, Mason W Freeman, Yuan-Di C Halvorsen
RATIONALE & OBJECTIVE: Hyperglycemia exacerbates the progression of chronic kidney disease (CKD), but most glucose-lowering therapies do not address morbidities associated with CKD. Sodium/glucose cotransporter 2 (SGLT2) inhibitors offer potential benefits to patients with diabetes and CKD, but their effectiveness may be diminished with decreased kidney function. We aimed to evaluate the safety and effectiveness of bexagliflozin, a novel SGLT2 inhibitor, in patients with type 2 diabetes and CKD...
May 13, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31076173/association-of-kidney-transplant-center-volume-with-3-year-clinical-outcomes
#2
Elizabeth M Sonnenberg, Jordana B Cohen, Jesse Y Hsu, Vishnu S Potluri, Matthew H Levine, Peter L Abt, Peter P Reese
RATIONALE & OBJECTIVE: A robust relationship between procedure volume and clinical outcomes has been demonstrated across many surgical fields. This study assessed whether a center volume-outcome relationship exists for contemporary kidney transplantation, specifically for diabetic recipients, older recipients (aged ≥65 years), and recipients of high kidney donor profile index (KDPI ≥ 85) kidneys. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Adult kidney-only transplant recipients who underwent transplantation between 2009 and 2013 (N = 79,581)...
May 7, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31076172/nephropathy-progression-in-african-americans-with-a-family-history-of-eskd-implications-for-clinical-trials-in-apol1-associated-nephropathy
#3
LETTER
Barry I Freedman, Mitzie Spainhour, Pamela J Hicks, Jolyn Turner, Julia Robertson, Carl D Langefeld, Mariana Murea, Jasmin Divers
No abstract text is available yet for this article.
May 7, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31040091/pathophysiology-and-management-of-hyperammonemia-in-organ-transplant-patients
#4
REVIEW
Harish Seethapathy, Andrew Z Fenves
Neurologic complications are common after solid-organ transplantation, occurring in one-third of patients. Immunosuppression-related neurotoxicity (involving calcineurin inhibitors and corticosteroids), opportunistic central nervous system infections, seizures, and delirium are some of the causes of neurologic symptoms following solid-organ transplantation. An uncommon often missed complication posttransplantation involves buildup of ammonia levels that can lead to rapid clinical deterioration even when treated...
April 27, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31040090/a-new-indication-for-pneumococcal-vaccination
#5
EDITORIAL
Michael Z David
No abstract text is available yet for this article.
April 27, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31040089/a-diet-rich-in-vegetables-and-fruit-and-incident-ckd-a-community-based-prospective-cohort-study
#6
Jong Hyun Jhee, Youn Kyung Kee, Jung Tak Park, Tae-Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
RATIONALE & OBJECTIVE: A diet rich in vegetables and fruit can lower blood pressure and may reduce cardiovascular risk. However, the association between this dietary pattern and incident chronic kidney disease in the general population is unknown. STUDY DESIGN: A community-based prospective cohort study. SETTING & PARTICIPANTS: 9,229 study participants with normal kidney function from the Korean Genome and Epidemiology Study database...
April 27, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31040088/hypertonic-mannitol-for-the-prevention-of-intradialytic-hypotension-a-randomized-controlled-trial
#7
Finnian R Mc Causland, Brian Claggett, Venkata S Sabbisetti, Petr Jarolim, Sushrut S Waikar
RATIONALE & OBJECTIVE: Intradialytic hypotension (IDH) is a common complication at the initiation of hemodialysis (HD) therapy, is associated with greater mortality, and may be related to relatively rapid shifts in plasma osmolality. This study sought to evaluate the effect of an intervention to minimize intradialytic changes in plasma osmolality on the occurrence of IDH. STUDY DESIGN: Double-blind, single-center, randomized, controlled trial. SETTING & PARTICIPANTS: Individuals requiring initiation of HD for acute or chronic kidney disease...
April 27, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31036390/reduced-estimated-gfr-and-cardiac-remodeling-a-population-based-autopsy-study
#8
Kensuke Izumaru, Jun Hata, Toshiaki Nakano, Yutaka Nakashima, Masaharu Nagata, Masayo Fukuhara, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya
RATIONALE & OBJECTIVE: Evidence suggests that cardiac remodeling, including left ventricular hypertrophy and myocardial fibrosis, develops with progression of kidney disease. Few studies have examined cardiac pathology across a range of estimated glomerular filtration rates (eGFRs), which was the objective of this investigation. STUDY DESIGN: Population-based cross-sectional study of deceased patients undergoing autopsy. SETTING & PARTICIPANTS: 334 of 694 consecutive deceased patients undergoing autopsy with available cardiac tissue, with a prior health examination within 6 years and without a prior diagnosis of heart disease...
April 26, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31036389/metabolic-acidosis-in-ckd-core-curriculum-2019
#9
REVIEW
Kalani L Raphael
Maintenance of normal acid-base homeostasis is one of the most important kidney functions. In chronic kidney disease, the capacity of the kidneys to excrete the daily acid load as ammonium and titratable acid is impaired, resulting in acid retention and metabolic acidosis. The prevalence of metabolic acidosis increases with declining glomerular filtration rate. Metabolic acidosis is associated with several clinically important complications, including chronic kidney disease progression, bone demineralization, skeletal muscle catabolism, and mortality...
April 26, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31031088/the-use-of-patient-reported-outcomes-in-patients-treated-with-maintenance-hemodialysis-a-perspective
#10
Nicola Elizabeth Anderson, Melanie Calvert, Paul Cockwell, Mary Dutton, Derek Kyte
There is increasing interest in the integration of patient-reported outcomes (PROs) into health care research and clinical practice for the benefit of patients with end-stage kidney disease receiving hemodialysis. In a research setting, PROs can be used as a patient-centered primary or secondary outcome in clinical studies. In routine care, PRO data may be used to support service delivery through benchmarking and audit or inform and enhance the care of the individual patient by improving patient-clinician communication...
April 25, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31031087/association-between-hypertension-and-kidney-function-decline-the-atherosclerosis-risk-in-communities-aric-study
#11
Zhi Yu, Casey M Rebholz, Eugenia Wong, Yuan Chen, Kunihiro Matsushita, Josef Coresh, Morgan E Grams
RATIONALE & OBJECTIVE: The relationship between hypertension, antihypertension medication use, and change in glomerular filtration rate (GFR) over time among individuals with preserved GFR requires investigation. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: 14,854 participants from the Atherosclerosis Risk in Communities (ARIC) Study. PREDICTORS: Baseline hypertension status (1987-1989) was categorized according to the 2017 American College of Cardiology/American Heart Association Clinical Practice Guideline as normal blood pressure, elevated blood pressure, stage 1 hypertension, stage 2 hypertension without medication, or stage 2 hypertension with medication...
April 25, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31031086/prediction-and-risk-stratification-of-kidney-outcomes-in-iga-nephropathy
#12
Tingyu Chen, Xiang Li, Yingxue Li, Eryu Xia, Yong Qin, Shaoshan Liang, Feng Xu, Dandan Liang, Caihong Zeng, Zhihong Liu
RATIONALE & OBJECTIVE: Immunoglobulin A nephropathy (IgAN) is common worldwide and has heterogeneous phenotypes. Predicting long-term outcomes and stratifying risk are important for clinical decision making and designing future clinical trials. STUDY DESIGN: Multicenter retrospective cohort study of 2,047 patients with IgAN. SETTING & PARTICIPANTS: Derivation and validation cohorts composed of 1,022 Chinese patients with IgAN from a single center and 1,025 patients with IgAN from 18 renal centers, respectively...
April 25, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31027884/the-impact-of-whole-exome-sequencing-on-kidney-disease-ontology-the-tip-of-the-iceberg
#13
EDITORIAL
Abdallah S Geara, Staci Kallish, Jonathan J Hogan
No abstract text is available yet for this article.
April 23, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31027883/effects-of-sevelamer-carbonate-in-patients-with-ckd-and-proteinuria-the-answer-randomized-trial
#14
Barbara Ruggiero, Matias Trillini, Lida Tartaglione, Silverio Rotondi, Elena Perticucci, Rocco Tripepi, Carolina Aparicio, Veruska Lecchi, Annalisa Perna, Francesco Peraro, Davide Villa, Silvia Ferrari, Antonio Cannata, Sandro Mazzaferro, Francesca Mallamaci, Carmine Zoccali, Antonio Bellasi, Mario Cozzolino, Giuseppe Remuzzi, Piero Ruggenenti, Donald E Kohan
RATIONALE & OBJECTIVE: Hyperphosphatemia is associated with increased risk for chronic kidney disease (CKD) progression and reduced antiproteinuric effects of renin-angiotensin system (RAS) blockers. We investigated whether the phosphate binder sevelamer carbonate may enhance the antiproteinuric effect of RAS inhibitors in patients with CKD. STUDY DESIGN: Phase 2, randomized, controlled, open-label, crossover trial. SETTING & PARTICIPANTS: Between November 2013 and December 2014, we enrolled 53 patients with CKD with estimated glomerular filtration rates (eGFRs)>15mL/min/1...
April 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31027882/anxiety-symptoms-mortality-and-hospitalization-in-patients-receiving-maintenance-dialysis-a-cohort-study
#15
Robbert W Schouten, Gertrud L Haverkamp, Wim L Loosman, Prataap K Chandie Shaw, Frans J van Ittersum, Yves F C Smets, Louis-Jean Vleming, Friedo W Dekker, Adriaan Honig, Carl E H Siegert
RATIONALE & OBJECTIVE: Anxiety symptoms are common in dialysis patients and have a large impact on quality of life. The association of anxiety symptoms with adverse clinical outcomes in dialysis patients is largely unknown. This study examined the association of anxiety symptoms with hospitalization and mortality in patients receiving maintenance dialysis. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Maintenance dialysis patients treated at 10 dialysis centers in the Netherlands between 2012 and 2016...
April 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31027881/quality-metrics-in-kidney-transplantation-current-landscape-trials-and-tribulations-lessons-learned-and-a-call-for-reform
#16
Jesse D Schold, Rachel E Patzer, Timothy L Pruett, Sumit Mohan
Quality metrics have a long history in the field of kidney transplantation. These metrics are highly visible, with significant ramifications to transplantation centers based on their use in regulatory review and other stakeholders. In this perspective, we review the history of quality metrics in this field, discuss the perceptions and empirical evidence evaluating the impact of metrics on care delivery, and summarize the current landscape of quality oversight. Based on the research findings and opinions of the transplantation community, we suggest that significant reforms are needed for the evaluation of quality in the field based on more appropriately aligning metrics with optimizing patient outcomes...
April 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31023501/eskd-or-cancer-given-the-choice-which-would-you-rather-have
#17
EDITORIAL
Kevan R Polkinghorne
No abstract text is available yet for this article.
April 22, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31010601/vascular-access-choice-complications-and-outcomes-in-children-on-maintenance-hemodialysis-findings-from-the-international-pediatric-hemodialysis-network-iphn-registry
#18
Dagmara Borzych-Duzalka, Rukshana Shroff, Gema Ariceta, Yok-Chin Yap, Fabio Paglialonga, Hong Xu, Hee Gyung Kang, Julia Thumfart, Karabay Bayazit Aysun, Constantinos J Stefanidis, Marc Fila, Lale Sever, Karel Vondrak, Attila J Szabo, Maria Szczepanska, Bruno Ranchin, Tuula Holtta, Ariane Zaloszyc, Ilmay Bilge, Bradley A Warady, Franz Schaefer, Claus Peter Schmitt
RATIONALE & OBJECTIVE: Arteriovenous fistulas (AVFs) have been recommended as the preferred vascular access for pediatric patients on maintenance hemodialysis (HD), but data comparing AVFs with other access types are scant. We studied vascular access choice, placement, complications, and outcomes in children. STUDY DESIGN: Prospective observational cohort study. SETTING & PARTICIPANTS: 552 children and adolescents from 27 countries on maintenance HD followed up prospectively by the International Pediatric HD Network (IPHN) Registry between 2012 and 2017...
April 19, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31005373/self-reported-urine-volume-in-hemodialysis-patients-predictors-and-mortality-outcomes-in-the-international-dialysis-outcomes-and-practice-patterns-study-dopps
#19
LETTER
Manfred Hecking, Keith P McCullough, Friedrich K Port, Brian Bieber, Hal Morgenstern, Hiroyasu Yamamoto, Rita S Suri, Michel Jadoul, Loreto Gesualdo, Jeffrey Perl, Bruce M Robinson
No abstract text is available yet for this article.
April 17, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31005372/antimalarials-in-iga-nephropathy-did-our-supportive-therapy-armamentarium-just-increase
#20
EDITORIAL
Jürgen Floege
No abstract text is available yet for this article.
April 17, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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