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Journals American Journal of Kidney Dis...

American Journal of Kidney Diseases

https://read.qxmd.com/read/38372688/considering-his-advanced-age
#1
EDITORIAL
Lorraine Mesagna
No abstract text is available yet for this article.
February 16, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38372687/magnesium-disorders-core-curriculum-2024
#2
REVIEW
Emmanuel A Adomako, Alan S L Yu
Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the genome. Despite its abundance, hypomagnesemia is common and often goes undiagnosed. This is in spite of epidemiologic data linking low magnesium with chronic diseases including diabetes mellitus. Clinically significant hypermagnesemia is encountered less frequently, but the presentation may be dramatic...
February 16, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38372686/sodium-glucose-cotransporter-2-inhibitors-and-magnesium-homeostasis
#3
REVIEW
Chintan V Shah, Matthew A Sparks, Chien-Te Lee
Magnesium (Mg2+ ), also known as "the forgotten ion," is the second most abundant intracellular cation and is essential in a broad range of intracellular physiological and biochemical reactions. Its deficiency, hypomagnesemia (Mg2+ <1.8mg/dL), is a prevalent condition and routinely poses challenges in its management in clinical practice. Sodium/glucose cotransporter 2 (SGLT2) inhibitors have emerged as a new class of drugs with treating hypomagnesemia as their unique extraglycemic benefit. The beneficial effect of SGLT2 inhibitors on magnesium balance in patients with diabetes with or without hypomagnesemia has been noted as a class effect in recent meta-analysis data from randomized clinical trials...
February 16, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38364956/continuous-kidney-replacement-therapy-and-survival-in-children-and-young-adults-findings-from-the-multi-national-we-rock-collaborative
#4
JOURNAL ARTICLE
Michelle C Starr, Katja M Gist, Huaiyu Zang, Nicholas J Ollberding, Shanthi Balani, Andrea Cappoli, Eileen Ciccia, Catherine Joseph, Aadil Kakajiwala, Aaron Kessel, Melissa Muff-Luett, María J Santiago Lozano, Matthew Pinto, Stephanie Reynaud, Sonia Solomon, Cara Slagle, Rachana Srivastava, Weiwen V Shih, Tennille Webb, Shina Menon
RATIONALE & OBJECTIVE: There are limited studies describing the epidemiology and outcomes of children and young adults receiving continuous kidney replacement therapy (CKRT). We aimed to describe associations between patient characteristics, CKRT prescription, and survival. STUDY DESIGN: Retrospective multicenter cohort study. SETTING: & Participants: 980 patients aged birth-25 years old who received CKRT between 2015 and 2021 at 1 of 32 centers in 7 countries participating in the Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Diseases (WE-ROCK)...
February 14, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38364955/time-varying-proteinuria-and-progression-of-iga-nephropathy-a-cohort-study
#5
JOURNAL ARTICLE
Chen Tang, Pei Chen, Feng-Lei Si, Ji-Cheng Lv, Su-Fang Shi, Xu-Jie Zhou, Li-Jun Liu, Hong Zhang
RATIONALE & OBJECTIVE: Proteinuria is a surrogate endpoint for predicting long-term kidney outcomes in IgA nephropathy (IgAN) with levels <1 g/d identified as a therapeutic target. However, this threshold has not been sufficiently studied. We aimed to quantify the associations of progression of IgAN with various levels of proteinuria. STUDY DESIGN: Observational cohort study. SETTING: & Participants: 1530 patients with IgAN and at least 12 months of follow-up at Peking University First Hospital...
February 14, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38363257/dialysis-catheter-tip-design-and-dysfunction-an-unsolved-challenge
#6
EDITORIAL
Pallavi Prasad, Tushar J Vachharajani
No abstract text is available yet for this article.
February 14, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38341125/apol1-nephropathy-risk-variants-through-the-life-course-a-review
#7
REVIEW
Ai Itoku, Jaya Isaac, Scott Wilson, Kimberly Reidy, Frederick Kaskel
Two variant alleles of the gene APOL1, known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The APOL1 protein contributes to innate immunity and may protect against trypanosoma, human immunodeficiency virus, salmonella, and leishmaniasis. However, the effects of carrying one or more RVs contribute to a variety of disease processes starting as early as in utero and can be exacerbated by other factors (or "second hits"). Indeed, these genetic variations interact with environmental exposures, infections, and systemic disease to modify health outcomes across one's lifespan...
February 8, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38300185/a-fit-for-purpose-approach-to-ckd-classification
#8
EDITORIAL
Jin Ho Hwang, Chi-Yuan Hsu
No abstract text is available yet for this article.
February 1, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38300186/how-much-patient-autonomy-is-too-much
#9
EDITORIAL
Chia-Ter Chao
No abstract text is available yet for this article.
January 30, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38281681/aptamer-based-proteomics-in-ckd
#10
EDITORIAL
Taesoo Kim, Eugene P Rhee
No abstract text is available yet for this article.
January 26, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38280640/association-of-kidney-cysts-with-progressive-ckd-after-radical-nephrectomy
#11
JOURNAL ARTICLE
Moldovan Sabov, Aleksandar Denic, Aidan F Mullan, Anthony C Luehrs, Timothy L Kline, Bradley J Erickson, Theodora A Potretzke, R Houston Thompson, Vidit Sharma, Peter C Harris, Andrew D Rule
RATIONALE & OBJECTIVE: Simple kidney cysts are common and usually considered of limited clinical relevance. They are associated with older age and lower glomerular filtration rate (GFR), but little is known of their association with progressive chronic kidney disease (CKD) which was the focus of this study. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: Patients with pre-surgical CT or MRI imaging who underwent a radical nephrectomy for a tumor...
January 25, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38276941/reducing-elevated-parathyroid-hormone-to-protect-bone-strength-in-end-stage-kidney-disease
#12
EDITORIAL
Tamara Isakova, Thomas L Nickolas
No abstract text is available yet for this article.
January 25, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38260929/improvements-in-kidney-outcomes-over-the-years-reason-for-optimism-but-a-challenge-for-trialists
#13
EDITORIAL
Doreen Zhu, Parminder K Judge, Richard Haynes
No abstract text is available yet for this article.
January 23, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38266973/metabolites-associated-with-uremic-symptoms-in-patients-with-ckd-findings-from-the-chronic-renal-insufficiency-cohort-cric-study
#14
JOURNAL ARTICLE
Kendra E Wulczyn, Tariq Shafi, Amanda Anderson, Hernan Rincon-Choles, Clary B Clish, Michelle Denburg, Harold I Feldman, Jiang He, Chi-Yuan Hsu, Tanika Kelly, Paul L Kimmel, Rupal Mehta, Robert G Nelson, Vasan Ramachandran, Ana Ricardo, Vallabh O Shah, Anand Srivastava, Dawei Xie, Eugene P Rhee, Sahir Kalim
RATIONALE & OBJECTIVE: The toxins contributing to uremic symptoms in patients with CKD are unknown. We sought to apply complementary statistical modeling approaches to data from untargeted plasma metabolomic profiling to identify solutes associated with uremic symptoms in patients with CKD. STUDY DESIGN: Cross-sectional. SETTING & PARTICIPANTS: 1,761 Chronic Renal Insufficiency Cohort (CRIC) participants with CKD not on dialysis. PREDICTORS: Measurement of 448 known plasma metabolites...
January 22, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38266972/monoclonal-immunoglobulin-crystalline-membranous-nephropathy
#15
Salvatore E Mignano, Virginie Pascal, Nnaemezie E Odioemene, William Forehand, Vincent Javaugue, Samar M Said, Sanjeev Sethi, Christophe Sirac, Samih H Nasr
Monoclonal immunoglobulin (MIg) crystalline nephropathies are rare lesions resulting from precipitation of MIgs in the kidney as intracellular or extracellular crystals. We describe a patient with multiple myeloma (IgGλ) and diabetes who presented with nephrotic range proteinuria. Kidney biopsy revealed membranous nephropathy superimposed on diabetic glomerulosclerosis. Glomeruli were negative for PLA2R, THSD7A, and NELL-1. Ultrastructurally, the subepithelial deposits were composed of crystals (ranging from rhomboid to rod to needle shaped), which failed to stain for immunoglobulins by routine immunofluorescence but stained for IgG + λ by paraffin immunofluorescence after pronase digestion...
January 22, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38266971/potentially-inappropriately-medication-prescriptions-among-medicare-patients-receiving-hemodialysis
#16
LETTER
Armando Silva Almodovar, Macarius Donneyong, Eric Seiber, Milap C Nahata
No abstract text is available yet for this article.
January 22, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38260930/quantity-versus-quality-of-anti-phospholipase-a2-receptor-1-autoantibodies-in-the-assessment-of-clinical-outcome-in-membranous-nephropathy-the%C3%A2-debate-continues
#17
EDITORIAL
Laurence H Beck
No abstract text is available yet for this article.
January 22, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38243995/implantation-biopsy-in-living-donor-kidney-transplantation-expectations-utility-and-limitations
#18
EDITORIAL
Junji Yamauchi, Isaac E Hall, Divya Raghavan
No abstract text is available yet for this article.
January 20, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38243994/toxic-nephropathies-of-the-tubulointerstitium-core-curriculum-2024
#19
REVIEW
Namrata Krishnan, Dennis G Moledina, Mark A Perazella
Toxic nephropathies are a clinically common group of disorders characterized by toxin-induced renal injury that can affect the glomerulus, vasculature, or tubulointerstitium. Various endogenous (eg, myoglobin, hemoglobin, monoclonal light chains, and lysozymes) and exogenous toxins (eg, therapeutic drugs, herbal medications, heavy metals, radiocontrast, intoxicants, and environmental exposures) have been implicated. The kidney's primary role of metabolism and excretion of substances via glomerular filtration and tubular secretion increases its susceptibility to their adverse effects...
January 19, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38242424/navigating-living-kidney-donation-and-transplantation-among-south-asian-canadians-the-action-project
#20
JOURNAL ARTICLE
Reetinder Kaur, Kara Schick-Makaroff, Phuc Dang, Ayumi Sasaki, Paula Neves, Istvan Mucsi, Jagbir Gill
RATIONALE & OBJECTIVE: South Asian (SA) Canadians with kidney failure have a 50-77% lower likelihood of kidney transplantation and are less likely to identify potential living kidney donors (LDs). This study aimed to identify, health system, patient, and community level barriers and facilitators for accessing living donor kidney transplantation (LDKT) in the SA community to inform the development of health system and community level interventions to address barriers. STUDY DESIGN: Qualitative study...
January 17, 2024: American Journal of Kidney Diseases
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