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Journals American Journal of Kidney Dis...

American Journal of Kidney Diseases

https://read.qxmd.com/read/38493377/anti-glomerular-basement-membrane-disease-broadening-the-spectrum
#1
EDITORIAL
Lynn D Cornell
No abstract text is available yet for this article.
March 14, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38490319/low-dose-continuous-kidney-replacement-therapy-and-mortality-in-critically-ill-patients-with-acute-kidney-injury-a-retrospective-cohort-study
#2
JOURNAL ARTICLE
Keisuke Okamoto, Hidetada Fukushima, Masahiko Kawaguchi, Kazuhiko Tsuruya
RATIONALE & OBJECTIVE: Continuous kidney replacement therapy (CKRT) is preferred when available for hemodynamically unstable acute kidney injury (AKI) patients in the intensive care unit (ICU). The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend a delivered CKRT dose of 20-25 mL/kg/h, however in Japan, doses are typically below this recommendation due to government health insurance system restrictions. This study investigated the association between mortality and dose of CKRT...
March 13, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38484869/trajectories-of-physical-resilience-among-older-veterans-with-stage-4-ckd
#3
JOURNAL ARTICLE
C Barrett Bowling, Theodore S Z Berkowitz, Brett T Burrows, Jessica E Ma, Heather E Whitson, Battista Smith, Steven D Crowley, Virginia Wang, Matthew L Maciejewski, Maren K Olsen
RATIONALE & OBJECTIVE: Although functional impairment is common among older adults with chronic kidney disease (CKD), functional reserve before an acute health event and physical resilience after have not been characterized in this population. The purpose of this study was to identify distinct patterns of physical function before and after an acute health event among older Veterans with Stage 4 CKD. STUDY DESIGN: Prospective cohort study. SETTING: & Participants: National sample of Veterans ≥70 years of age with an estimated glomerular filtration rate (eGFR) <30 ml/min/1...
March 12, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38484868/hereditary-transthyretin-amyloidosis-impact-of-classic-and-new-treatments-on-kidney-function
#4
REVIEW
Evelyn Meléndrez-Balcázar, Karla Aranda-Vela, Alberto Cervantes-Hernández, Samuel López-Cureño
Hereditary transthyretin amyloidosis (ATTRv) is a rare, progressive, and life-threatening disease caused by misfolded transthyretin (TTR) proteins that aggregate as abnormal amyloid fibrils and accumulate throughout the body. The kidney is one of the main organs affected in amyloid light chain (AL) amyloidosis and ATTRv amyloidosis. The most common clinical presentation is proteinuria, which consists mainly of albumin; this is the first step in the natural history of ATTRv nephropathy. Not all TTR mutations are equal in terms of ATTRv kidney involvement...
March 12, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38479460/gestational-exposure-to-maternal-systemic-glucocorticoids-and-childhood-risk-of-ckd
#5
JOURNAL ARTICLE
You-Lin Tain, Lung-Chih Li, Hsiao-Ching Kuo, Chien-Ning Hsu
BACKGROUND & OBJECTIVES: The potential effects of antenatal glucocorticoid exposure on the health of children are unclear. We examined the association of gestational exposure to maternal systemic glucocorticoids (SG) and the risk of developing chronic kidney disease (CKD) in childhood. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Newborns cared for at the largest healthcare delivery system in Taiwan between 2004 and 2018...
March 11, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38479459/ekfc-versus-ckd-epi-equation-in-young-adults-no-definitive-answer
#6
LETTER
Pierre Delanaye, Hans Pottel
No abstract text is available yet for this article.
March 11, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38490320/in-reply-to-ekfc-versus-ckd-epi-equation-in-young-adults-no-definitive-answer
#7
LETTER
Lesley A Inker, Ogechi M Adingwupu, Andrew S Levey
No abstract text is available yet for this article.
March 8, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38461949/thiazides-for-nephrolithiasis-prevention-written-in-stone
#8
EDITORIAL
Anna L Zisman
No abstract text is available yet for this article.
March 8, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38458377/a-holistic-framework-for-the-evaluation-of-kidney-function-in-a-gender-diverse-landscape
#9
JOURNAL ARTICLE
Keila Turino Miranda, Dina N Greene, David Collister, Matthew D Krasowski, Sofia B Ahmed, Lauren R Cirrincione, Sylvia E Rosas, Nathalie Saad, Christina C Pierre
The most commonly used equations to estimate glomerular filtration rate incorporate a binary male-female sex coefficient, which has important implications for the care of transgender, gender-diverse, and non-binary (TGD) people. Whether "sex assigned at birth" or a binary "gender identity" is most appropriate for the computation of estimated glomerular filtration rate (eGFR) is unknown. Furthermore, the use of gender-affirming hormone therapy (GAHT) for the development of physical changes to align TGD people with their affirmed gender is increasingly common, and may result in changes in serum creatinine and cystatin C, biomarkers commonly used to estimate glomerular filtration rate...
March 6, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38458376/addressing-housing-issues-among-people-with-kidney-disease-importance-challenges-and-recommendations
#10
JOURNAL ARTICLE
Tessa K Novick, Ben King
Kidney disease disproportionately impacts people with low socioeconomic status, and low socioeconomic status is associated with worse outcomes for people with kidney disease. Unstable housing, which includes housing insecurity and homelessness, is increasing due to rising housing costs. There is mounting evidence that unstable housing and other health-related social needs are partially driving worse outcomes for people with low socioeconomic status. In this perspective, we consider challenges to addressing housing for people with kidney disease, such as difficulty with identification of those with unstable housing, strict eligibility criteria for housing support, inadequate supply of affordable housing, and flaws in communities' prioritization of affordable housing...
March 6, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38452919/urinary-plasminogen-as-a-marker-of-disease-progression-in-human-glomerular-disease
#11
JOURNAL ARTICLE
Marina de Cos, Gohar Mosoyan, Kinsuk Chauhan, Jonathan P Troost, Jenny S Wong, Sean Lefferts, Paul Morgan, Kristin Meliambro, Marc Egerman, Justina Ray, Tom Parker, Daniel Levine, Surya Seshan, Yoni Bardash, Benjamin Horowitz, Candice A Kent, Melissa M Shaw, Alan Perlman, Dennis G Moledina, Steven G Coca, Kirk N Campbell
RATIONALE & OBJECTIVE: Glomerular disorders have a highly variable clinical course and biomarkers that reflect molecular mechanisms underlying progression are needed. Based on our previous work identifying plasminogen as a direct cause of podocyte injury, we designed this study to test the association between urine plasmin(ogen) (i.e., plasmin and its precursor plasminogen) and end-stage kidney disease (ESKD). STUDY DESIGN: Multicenter cohort study. SETTING & PARTICIPANTS: 1010 patients enrolled in the CureGN Cohort with biopsy-proven glomerular disease (focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A nephropathy)...
March 5, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38452918/enhancing-kidney-transplantation-and-the-role-of-xenografts-report-of-a-scientific-workshop-sponsored-by-the-national-kidney-foundation
#12
JOURNAL ARTICLE
Andrew B Adams, Emily A Blumberg, John S Gill, Eliezer Katz, Tatsuo Kawai, Jesse D Schold, Megan Sykes, Alfred Tector, David H Sachs
Chronic kidney disease affects an estimated 37 million people in the United States; of these, >800,000 have end-stage renal disease requiring chronic dialysis or a kidney transplant to survive. Despite efforts to increase the donor kidney supply, approximately 100,000 people are registered on the kidney transplant waitlist with no measurable decrease over the past 2 decades. Outcomes of kidney transplantation are significantly better than for chronic dialysis: kidney transplant recipients have lower rates of mortality and cardiovascular events and better quality of life, but waitlist time matters...
March 5, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38447708/human-factors-contributing-to-infection-prevention-in-outpatient-hemodialysis-centers-a-mixed-methods-study
#13
JOURNAL ARTICLE
Sarah Henrickson Parker, Matthew N Jesso, Laurie D Wolf, Kerry Avondet Leigh, Stephanie Booth, Nicole Gualandi, Renee E Garrick, Alan S Kliger, Priti R Patel
RATIONALE & OBJECTIVE: Infection prevention efforts in dialysis centers can avert patient morbidity and mortality but are challenging to implement. The objective of this study was to better understand how the design of the work system might contribute to infection prevention in outpatient dialysis centers. STUDY DESIGN: Mixed methods, observational study. SETTING & PARTICIPANTS: Six dialysis facilities across the United States were visited by a multidisciplinary team over 8 months...
March 4, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38447707/impact-of-prior-abdominal-procedures-on-peritoneal-dialysis-catheter-outcomes-findings-from-the-north-american-peritoneal-dialysis-catheter-registry
#14
JOURNAL ARTICLE
Wazaira A Khan, Matthew Oliver, John H Crabtree, Alix Clarke, Sean Armstrong, Danielle Fox, Rachel Fissell, Arsh K Jain, Sarbjit V Jassal, Susie L Hu, Peter Kennealey, Scott Liebman, Brendan McCormick, Bogdan Momciu, Robert P Pauly, Beth Pellegrino, Jeffrey Perl, James L Pirkle, Troy J Plumb, Pietro Ravani, Rebecca Seshasai, Ankur Shah, Nikhil Shah, Jenny Shen, Gurmukteshwar Singh, Karthik Tennankore, Jaime Uribarri, Murray Vasilevsky, Robert Yang, Robert R Quinn
RATIONALE & OBJECTIVE: A history of prior abdominal procedures may influence the likelihood of referral for peritoneal dialysis (PD) catheter insertion. To guide clinical decision making in this population, this study examined the association between prior abdominal procedures and outcomes in patients undergoing PD catheter insertion. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Adults undergoing their first PD catheter insertion between November 1, 2011 and November 1, 2020, at 11 institutions in Canada and the US participating in the International Society for Peritoneal Dialysis (ISPD) North American Catheter Registry...
March 4, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38447706/residential-racial-and-ethnic-segregation-and-post-kidney-transplant-dementia-allograft-loss-and-mortality
#15
LETTER
Yusi Chen, Yiting Li, Yi Liu, Byoungjun Kim, Jessica M Ruck, Maya N Clark-Cutaia, Aarti Mathur, Tanjala S Purnell, Roland J Thorpe, Deidra C Crews, Sarah L Szanton, Dorry L Segev, Mara McAdams-DeMarco
No abstract text is available yet for this article.
March 4, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38431186/use-of-immunoadsorption-and-plasma-exchange-for-treating-anti-glomerular-basement-membrane-disease-clinical-experience-in-germany
#16
LETTER
Friedrich A von Samson-Himmelstjerna, Nassim Kakavand, Jakob C Voran, Benedikt Kolbrink, Kevin Schulte
No abstract text is available yet for this article.
February 29, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38423161/plasma-levels-of-polyunsaturated-fatty-acids-and-adverse-kidney-outcomes
#17
JOURNAL ARTICLE
Hee Byung Koh, Hyung Woo Kim, Young Su Joo, Chan-Young Jung, Hyo Jeong Kim, Tae Ik Chang, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
RATIONALE & OBJECTIVE: Many studies have reported polyunsaturated fatty acids (PUFA) as significant predictors of cardiovascular disease, but little is known about the relationship between PUFA levels and chronic kidney disease (CKD). This study explored this relationship among individuals with and without CKD. STUDY DESIGN: Prospective observational cohort study. SETTING & PARTICIPANTS: 78,950 participants without CKD (cohort 1) and 7,233 participants with CKD (cohort 2) in the UK Biobank Study with PUFA levels measured between 2007 and 2010...
February 27, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38423160/changes-in-cognitive-function-after-kidney-transplantation-a-longitudinal-cohort-study
#18
JOURNAL ARTICLE
Aditi Gupta, Jonathan D Mahnken, Joshua Bernal, Palash Sharma, Rebecca J Lepping, Robert N Montgomery, David K Johnson, Adam Parks, Jeffrey M Burns, David A Drew, Mark J Sarnak, William M Brooks
RATIONALE & OBJECTIVE: Kidney disease negatively affects cognition. We assessed the effect of kidney transplantation (KT) on different cognitive domains. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: We examined pre- to post-KT cognition in patients waitlisted for KT at an academic center. PREDICTORS: Transplant status. We measured cognitive function pre-KT (n=101), three months post-KT (n=78), and 1-year post-KT (n=83)...
February 27, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38423159/hot-spot-of-complement-factor-i-rare-variant-p-ile357met-in-patients-with-hemolytic-uremic-syndrome
#19
Nora Schwotzer, Fadi Fakhouri, Paula Vieira Martins, Yahsou Delmas, Sophie Caillard, Julien Zuber, Olivier Moranne, Laurent Mesnard, Véronique Frémeaux-Bacchi, Carine El-Sissy
Atypical haemolytic uremic syndrome (aHUS) is a rare kidney disease due to a dysregulation of the complement alternative pathway (AP). Complement factor I (CFI) negatively regulates the AP and CFI gene rare variants have been associated to aHUS with a low disease penetrance. We report 10 unrelated cases of HUS associated to a rare CFI variant p.Ile357Met (c.1071T>G). All patients with isolated p.Ile357Met CFI missense variant were retrospectively identified among patients included between January 2007 and January 2022 in the French HUS Registry...
February 27, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38493378/designing-an-implementable-clinical-prediction-model-for-near-term-mortality-and-long-term-survival-in-patients-on-maintenance-hemodialysis
#20
JOURNAL ARTICLE
Benjamin A Goldstein, Chun Xu, Jonathan Wilson, Ricardo Henao, Patti L Ephraim, Daniel E Weiner, Tariq Shafi, Julia J Scialla
RATIONALE & OBJECTIVE: The life expectancy of patients treated with maintenance hemodialysis (MHD) is heterogeneous. Knowledge of life-expectancy may focus care decisions on near-term versus long-term goals. The current tools are limited and focus on near-term mortality. Here, we develop and assess potential utility for predicting near-term mortality and long-term survival on MHD. STUDY DESIGN: Predictive modeling study. SETTING & PARTICIPANTS: 42,351 patients contributing 997,381 patient months over 11 years, abstracted from the electronic health record (EHR) system of midsize, nonprofit dialysis providers...
February 21, 2024: American Journal of Kidney Diseases
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