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American Journal of Kidney Diseases

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https://read.qxmd.com/read/31262591/major-advancements-in-slowing-diabetic-kidney-disease-progression-focus-on-sglt2-inhibitors
#1
EDITORIAL
George L Bakris
No abstract text is available yet for this article.
June 28, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31257051/implantable-defibrillators-for-primary-prevention-of-sudden-death-in-patients-on-dialysis
#2
EDITORIAL
Patrick H Pun, Sana M Al-Khatib
No abstract text is available yet for this article.
June 27, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31257050/are-there-consequences-of-adolescent-blood-pressure-on-kidney-function-in-adulthood
#3
EDITORIAL
Douglas L Blowey, Joseph T Flynn, Bradley A Warady
No abstract text is available yet for this article.
June 27, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31257049/more-evidence-to-suggest-a-relation-of-blood-pressure-to-long-term-progression-of-kidney-disease-is-it-causal
#4
EDITORIAL
Wendy McCallum, Elaine Ku, Mark J Sarnak
No abstract text is available yet for this article.
June 27, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31255336/transplanting-the-untransplantable
#5
Courtenay M Holscher, Kyle R Jackson, Dorry L Segev
With implementation of the Kidney Allocation System, the growth of kidney paired donation programs, and advances in desensitization and immunosuppression, the outlook for "untransplantable" kidney transplantation candidates has never been more promising. The Kidney Allocation System prioritized compatible matches for candidates with calculated panel-reactive antibody levels of 98%, 99%, or 100% and broadened allocation of non-A1 and non-A1-B subgroup kidneys to blood group type B candidates. Concurrently, the growth of kidney paired donation programs and use of incompatible transplantation as part of kidney paired donation to achieve "more compatible" kidney transplantation has improved options for candidates with an incompatible living donor...
June 26, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31255335/comparative-effectiveness-of-medical-therapy-percutaneous-revascularization-and-surgical-coronary-revascularization-in-cardiovascular-risk-subgroups-of-patients-with-ckd-a-retrospective-cohort-study-of-medicare-beneficiaries
#6
David M Charytan, Tanya Natwick, Craig A Solid, Shuling Li, Tingting Gong, Charles A Herzog
RATIONALE & OBJECTIVE: Prior studies suggesting that medical therapy is inferior to percutaneous (percutaneous coronary intervention [PCI]) or surgical (coronary artery bypass grafting [CABG]) coronary revascularization in chronic kidney disease (CKD) have not adequately considered medication optimization or baseline cardiovascular risk and have infrequently evaluated progression to kidney failure. We compared, separately, the risks for kidney failure and death after treatment with PCI, CABG, or optimized medical therapy for coronary disease among patients with CKD stratified by cardiovascular disease risk...
June 26, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31255334/glucose-control-and-the-effect-of-empagliflozin-on-kidney-outcomes-in-type-2-diabetes-an-analysis-from-the-empa-reg-outcome-trial
#7
LETTER
Mark E Cooper, Silvio E Inzucchi, Bernard Zinman, Stefan Hantel, Maximilian von Eynatten, Christoph Wanner, Audrey Koitka-Weber
No abstract text is available yet for this article.
June 26, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31255333/second-chance-placement-of-hemodialysis-patients-after-involuntary-discharge-for-disruptive-behavior
#8
Michael Allon, Denyse Thornley-Brown, Dana V Rizk, Arlene J Carrasquillo
A small subset of hemodialysis patients exhibits persistently disruptive behavior. When all reasonable attempts to stop such behavior have been exhausted, they may undergo involuntary discharge from their dialysis unit. Such patients typically present repeatedly to the emergency department for urgent inpatient dialysis. We describe a novel approach to achieve a successful "second-chance" placement at a new outpatient dialysis unit. The patients were required to dialyze in the inpatient unit for a minimum of 3 months, during which their compliance and behavior were observed closely...
June 26, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31227227/ethical-issues-in-pragmatic-cluster-randomized-trials-in-dialysis-facilities
#9
Cory E Goldstein, Charles Weijer, Monica Taljaard, Ahmed A Al-Jaishi, Erika Basile, Jamie Brehaut, Charles L Cook, Jeremy M Grimshaw, Eduardo Lacson, Craig Lindsay, Meg Jardine, Laura M Dember, Amit X Garg
A pragmatic cluster-randomized trial (CRT) is a research design that may be used to efficiently test promising interventions that directly inform dialysis care. While the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials provides general ethical guidance for CRTs, the dialysis setting raises additional considerations. In this article, we outline ethical issues raised by pragmatic CRTs in dialysis facilities. These issues may be divided into 7 key domains: justifying the use of cluster randomization, adopting randomly allocated individual-level interventions as a facility standard of care, conducting benefit-harm analyses, gatekeepers and their responsibilities, obtaining informed consent from research participants, patient notification, and including vulnerable participants...
June 18, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31227226/physiology-and-pathophysiology-of-potassium-homeostasis-core-curriculum-2019
#10
REVIEW
Biff F Palmer, Deborah J Clegg
Total-body potassium (K+ ) content and appropriate distribution of K+ across the cell membrane is vitally important for normal cellular function. Total-body K+ content is determined by changes in excretion of K+ by the kidneys in response to intake levels. Under normal conditions, insulin and β-adrenergic tone also make important contributions in maintaining internal distribution of K+ . However, despite these homeostatic pathways, disorders of altered K+ homeostasis are common. Appreciating the pathophysiology and regulatory influences that determine the internal distribution and external balance of K+ is critical in designing effective treatments to restore K+ homeostasis...
June 18, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31227225/direct-delivery-of-kidney-transplant-education-to-black-and-low-income-patients-receiving-dialysis-a-randomized-controlled-trial
#11
Amy D Waterman, John Devin Peipert, Anna-Michelle McSorley, Christina J Goalby, Jennifer L Beaumont, Leanne Peace
RATIONALE & OBJECTIVE: Compared with others, black and low-income patients receiving dialysis are less likely to receive kidney transplantation (KT) education within dialysis centers. We examined the efficacy of 2 supplementary KT education approaches delivered directly to patients. STUDY DESIGN: Prospective, 3-arm parallel-group, randomized, controlled trial. SETTINGS & PARTICIPANTS: Adult, black, and white low-income patients receiving dialysis in Missouri...
June 18, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31221530/genetics-of-blood-pressure-regulation-possible-paths-in-the-labyrinth
#12
EDITORIAL
Luisa Foco, Cristian Pattaro
No abstract text is available yet for this article.
June 17, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31221529/women-s-reproductive-health-for-the-nephrologist
#13
Anna Burgner, Michelle A Hladunewich
Women with chronic kidney disease (CKD) are faced with complex decisions and significant challenges during their reproductive years. Contraceptive choices have a variety of side effects that can disproportionately affect women with CKD, limiting choice. CKD itself and the therapies needed to treat severe disease can affect future fertility. When conception is desired, young women with CKD must plan meticulously because an ill-timed pregnancy can result in disease progression or flare and exposure of an unborn child to potentially teratogenic medications...
June 17, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31221528/death-and-recovery-of-kidney-function-among-patients-continued-on-dialysis-after-discharge-from-hospital-stays-complicated-by-acute-kidney-injury-a-cohort-study
#14
Edward G Clark, Swapnil Hiremath, Manish M Sood, Ron Wald, Amit X Garg, Samuel A Silver, Carl van Walraven
RATIONALE & OBJECTIVE: Some patients who survive an inpatient episode of acute kidney injury (AKI) treated with dialysis (AKI-D) will require long-term outpatient dialysis. Factors that predict whether patients with AKI-D die or recover kidney function sufficiently to stop dialysis during the following year are poorly described and were the focus of this study. STUDY DESIGN: Population-based retrospective cohort study. SETTING & PARTICIPANTS: 2,771 individuals, identified using population-based data sets, who required outpatient dialysis after an inpatient episode of AKI-D in Ontario, Canada, between January 1, 2008, and September 30, 2015...
June 17, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31204195/idiopathic-retroperitoneal-fibrosis-long-term-risk-and-predictors-of-relapse
#15
Francesca Raffiotta, Rachele da Silva Escoli, Silvana Quaglini, Carla Rognoni, Lucia Sacchi, Valentina Binda, Piergiorgio Messa, Gabriella Moroni
RATIONALE & OBJECTIVE: Idiopathic retroperitoneal fibrosis (IRF) is a rare disorder of unknown cause. Medical therapy can induce remission, but disease relapses are common. This study sought to characterize long-term outcomes of IRF and the factors associated with disease recurrences. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Retrospective analysis of 50 patients with IRF prospectively followed up for 8.9 (IQR, 4...
June 13, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31204194/renal-vasculitis-and-pauci-immune-glomerulonephritis-associated-with-immune-checkpoint-inhibitors
#16
Alexander J Gallan, Ellen Alexander, Pankti Reid, Fouad Kutuby, Anthony Chang, Kammi J Henriksen
Immune checkpoint inhibitors are increasingly used to treat a variety of solid-organ and hematologic cancers. However, overactivation of the immune system can lead to immune-related adverse events, which are increasingly recognized in the kidney. There have been only rare reported cases of checkpoint inhibitor-associated glomerulonephritis and renal vasculitis, although vasculitis in other organs has been well described. We report 4 cases of renal vasculitis or pauci-immune glomerulonephritis after checkpoint inhibitor therapy...
June 13, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31204193/outpatient-dialysis-for-acute-kidney-injury-progress-and-pitfalls
#17
Michael Heung
Dialysis-requiring acute kidney injury (AKI) has increased markedly in the United States. At the same time, mortality rates have recently improved. As such, increasing numbers of patients with AKI are surviving to hospital discharge, including up to 30% who will continue to require outpatient dialysis. In recent years, policy changes have significantly affected the care of this high-risk population. Beginning in 2017, new legislation reversed a previous Centers for Medicare & Medicaid Services policy that prohibited dialysis for AKI at end-stage renal disease (ESRD) facilities...
June 13, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31200978/machine-learning-in-glomerular-diseases-promise-for-precision-medicine
#18
EDITORIAL
Girish N Nadkarni, Kumardeep Chaudhary, Steven G Coca
No abstract text is available yet for this article.
June 11, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31200977/acute-kidney-injury-associated-with-human-granulocytic-anaplasmosis-a-case-report
#19
Min Zhuo, Hila Calev, Staci J Saunders, Jiahua Li, Isaac E Stillman, John Danziger
Tick-borne illnesses are a growing problem in the United States. Human granulocytic anaplasmosis (HGA), carried by the Ixodes scapularis tick, is caused by Anaplasma phagocytophilum. While the clinical manifestations of HGA may be protean, ranging from asymptomatic infection to life-threatening multiorgan failure, renal involvement is uncommon. We report a case of a 64-year-old man presenting with a febrile illness and acute nephritis in the setting of HGA infection. The patient's kidney biopsy was characterized by a membranoproliferative glomerulonephritis pattern and acute interstitial inflammation...
June 11, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31200976/the-association-of-altitude-and-the-prevalence-of-anemia-among-people-with-ckd
#20
LETTER
Yue-Harn Ng, Orrin Myers, Xin Shore, V Shane Pankratz, Keith C Norris, Joseph A Vassalotti, Christos Argyropoulos
No abstract text is available yet for this article.
June 11, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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