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American Journal of Kidney Diseases

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https://read.qxmd.com/read/31515140/early-antibody-mediated-kidney-transplant-rejection-associated-with-anti-vimentin-antibodies-a-case-report
#1
Christie Rampersad, James Shaw, Ian W Gibson, Chris Wiebe, David N Rush, Peter W Nickerson, Julie Ho
Improving precision in predicting alloreactivity is an important unmet need and may require individualized consideration of non-HLA antibodies. We report a 21-year-old man with kidney failure from immunoglobulin A nephropathy who met all traditional criteria for a "low-risk" transplant for immune memory. He was unsensitized and received a haplotype-matched living donor kidney transplant from his mother. There were no anti-HLA donor-specific antibodies and flow cross-match was negative. After immediate function, he developed delayed graft function on postoperative day 2...
September 9, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31515139/characteristics-associated-with-peritoneal-dialysis-technique-failure-are-we-asking-the-right-questions
#2
EDITORIAL
Annie-Claire Nadeau-Fredette, Joanne M Bargman
No abstract text is available yet for this article.
September 9, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31515138/cefepime-as-empirical-peritoneal-dialysis-associated-peritonitis-treatment-something-to-dwell-on
#3
EDITORIAL
Muthana Al Sahlawi, Adrian Liew, Jeffrey Perl
No abstract text is available yet for this article.
September 9, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31515137/dietary-patterns-and-mortality-in-a-multinational-cohort-of-adults-receiving-hemodialysis
#4
Valeria M Saglimbene, Germaine Wong, Armando Teixeira-Pinto, Marinella Ruospo, Vanessa Garcia-Larsen, Suetonia C Palmer, Patrizia Natale, Katrina Campbell, Juan-Jesus Carrero, Peter Stenvinkel, Letizia Gargano, Angelo M Murgo, David W Johnson, Marcello Tonelli, Rubén Gelfman, Eduardo Celia, Tevfik Ecder, Amparo G Bernat, Domingo Del Castillo, Delia Timofte, Marietta Török, Anna Bednarek-Skublewska, Jan Duława, Paul Stroumza, Martin Hansis, Elisabeth Fabricius, Paolo Felaco, Charlotta Wollheim, Jörgen Hegbrant, Jonathan C Craig, Giovanni F M Strippoli
RATIONALE & OBJECTIVE: Clinical practice guidelines for dietary intake in hemodialysis focus on individual nutrients. Little is known about associations of dietary patterns with survival. We evaluated the associations of dietary patterns with cardiovascular and all-cause mortality among adults treated by hemodialysis. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: 8,110 of 9,757 consecutive adults on hemodialysis (January 2014 to June 2017) treated in a multinational private dialysis network and with analyzable dietary data...
September 9, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31515136/patient-navigation-addressing-social-challenges-in-dialysis-patients
#5
Lilia Cervantes, Romana Hasnain-Wynia, John F Steiner, Michel Chonchol, Stacy Fischer
Members of racial and ethnic minority groups make up nearly 50% of US patients with end-stage kidney disease and face a disproportionate burden of socioeconomic challenges (ie, low income, job insecurity, low educational attainment, housing instability, and communication challenges) compared with non-Hispanic whites. Patients with end-stage kidney disease who face social challenges often have poor patient-centered and clinical outcomes. These challenges may have a negative impact on quality-of-care performance measures for dialysis facilities caring for primarily minority and low-income patients...
September 9, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31492489/nephrology-in-the-academic-intensive-care-unit-a-qualitative-study-of-interdisciplinary-collaboration
#6
Justin T Clapp, Sushmitha P Diraviam, Meghan B Lane-Fall, Julia E Szymczak, Madhavi Muralidharan, Jamison J Chung, Jacob T Gutsche, Martha A Q Curley, Jeffrey S Berns, Lee A Fleisher
RATIONALE & OBJECTIVE: Collaboration between nephrology consultants and intensive care unit (ICU) teams is important in light of the high incidence of acute kidney injury in today's ICUs. Although there is considerable debate about how nephrology consultants and ICU teams should collaborate, communicative dynamics between the 2 parties remain poorly understood. This article describes interactions between nephrology consultants and ICU teams in the academic medical setting. STUDY DESIGN: Focused ethnography using semi-structured interviews and participant observation...
September 3, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31492488/the-argument-for-abolishing-cardiac-screening-of-asymptomatic-kidney-transplant-candidates
#7
Adnan Sharif
Cardiovascular disease is the leading cause of death for individuals with end-stage renal disease. Due to concern about cardiac fitness, international guidelines support screening algorithms based on clinical risk factors for people with kidney failure who wish to consider kidney transplantation surgery. The stated aim of cardiac screening is to identify asymptomatic kidney transplantation candidates with potentially significant pathology that either allows risk stratification or facilitates intervention. This will enable some to proceed toward kidney transplant listing while others will be denied kidney transplantation due to perceived risks...
September 3, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31492487/patient-reported-outcome-measures-for-adults-with-kidney-disease-current-measures-ongoing-initiatives-and-future-opportunities-for-incorporation-into-patient-centered-kidney-care
#8
REVIEW
Devika Nair, F Perry Wilson
Tools that measure patients' experiences and perceptions of disease are increasingly being recognized as important components of a multidisciplinary personalized approach to care. These patient-reported outcome measures (PROMs) have the ability to provide clinicians, researchers, and policymakers with valuable insights into patients' symptoms and experiences that are unable to be ascertained by laboratory markers alone. If developed rigorously, studied systematically, and used judiciously, PROMs can effectively incorporate the patient voice into clinical care, clinical trials, and health care policy...
September 3, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31492486/ckd-in-china-evolving-spectrum-and-public-health-implications
#9
Chao Yang, Haibo Wang, Xinju Zhao, Kunihiro Matsushita, Josef Coresh, Luxia Zhang, Ming-Hui Zhao
Diabetes is the leading cause of kidney failure worldwide, whereas glomerulonephritis has been predominant in developing countries such as China. The prevalence of obesity and diabetes has increased dramatically in developing countries, substantially affecting the patterns of chronic kidney disease (CKD) observed in these regions. Using data from the Hospital Quality Monitoring System to evaluate changes in the spectrum of non-dialysis-dependent CKD in China, we have observed an increase in the percentage of patients with CKD due to diabetes, which has exceeded that of CKD due to glomerulonephritis since 2011, as well as an increase in hypertensive nephropathy and, in some regions, obstructive kidney disease (mostly associated with kidney stones)...
September 3, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31473019/the-controversy-of-contrast-induced-nephropathy-with-intravenous-contrast-what-is-the-risk
#10
REVIEW
Michael R Rudnick, Amanda K Leonberg-Yoo, Harold I Litt, Raphael M Cohen, Susan Hilton, Peter P Reese
Contrast-induced nephropathy (CIN) has long been observed in both experimental and clinical studies. However, recent observational studies have questioned the prevalence and severity of CIN following intravenous contrast exposure. Initial studies of acute kidney injury following intravenous contrast were limited by the absence of control groups or contained control groups that did not adjust for additional acute kidney injury risk factors, including prevalent chronic kidney disease, as well as accepted prophylactic strategies...
August 28, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31473018/alkali-therapy-for-respiratory-acidosis-a-medical-controversy
#11
Horacio J Adrogué, Nicolaos E Madias
Alkali therapy for certain organic acidoses remains a topic of ongoing controversy, but little attention has been given to a related medical controversy, namely the prescription of alkali for respiratory acidosis. We first describe the determinants of carbon dioxide retention in the 2 types of respiratory failure; hypercapnic respiratory failure and hypoxemic respiratory failure with coexisting hypercapnia. We then highlight the deleterious consequences of severe acidemia for several organ systems, particularly the cardiovascular and central nervous systems...
August 28, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31473020/change-in-albuminuria-and-gfr-as-end-points-for-clinical-trials-in-early-stages-of-ckd-a-scientific-workshop-sponsored-by-the-national-kidney-foundation-in-collaboration-with-the-us-food-and-drug-administration-and-european-medicines-agency
#12
Andrew S Levey, Ron T Gansevoort, Josef Coresh, Lesley A Inker, Hiddo L Heerspink, Morgan E Grams, Tom Greene, Hocine Tighiouart, Kunihiro Matsushita, Shoshana H Ballew, Yingying Sang, Edward Vonesh, Jian Ying, Tom Manley, Dick de Zeeuw, Kai-Uwe Eckardt, Adeera Levin, Vlado Perkovic, Luxia Zhang, Kerry Willis
The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) are currently willing to consider a 30% to 40% glomerular filtration rate (GFR) decline as a surrogate end point for kidney failure for clinical trials of kidney disease progression under appropriate conditions. However, these end points may not be practical for early stages of kidney disease. In March 2018, the National Kidney Foundation sponsored a scientific workshop in collaboration with the FDA and EMA to evaluate changes in albuminuria or GFR as candidate surrogate end points...
August 23, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31451331/targeting-the-gut-for-early-diagnosis-prevention-and-cure-of-diabetic-kidney-disease-is-the-phenyl-sulfate-story-another-step-forward
#13
EDITORIAL
Enrico Fiaccadori, Carmela Cosola, Alice Sabatino
No abstract text is available yet for this article.
August 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31451330/artificial-intelligence-in-nephrology-core-concepts-clinical-applications-and-perspectives
#14
Olivier Niel, Paul Bastard
Artificial intelligence is playing an increasingly important role in many fields of medicine, assisting physicians in most steps of patient management. In nephrology, artificial intelligence can already be used to improve clinical care, hemodialysis prescriptions, and follow-up of transplant recipients. However, many nephrologists are still unfamiliar with the basic principles of medical artificial intelligence. This review seeks to provide an overview of medical artificial intelligence relevant to the practicing nephrologist, in all fields of nephrology...
August 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31451329/treatment-of-membranous-nephropathy-in-patients-with-thsd7a-antibodies-using-immunoadsorption
#15
Julia Weinmann-Menke, Stefan Holtz, Daniel Sollinger, Mara Dörken, Simone Boedecker, Beate Schamberger, Frederick Pfister, Kerstin Amann, Jens Lutz
Antibodies against THSD7A (thrombospondin type 1 domain-containing protein 7A) have been proposed to play a causal role in the development of nephrotic syndrome in patients with THSD7A antibody-positive membranous nephropathy. We hypothesized that removal of these antibodies from plasma could lead to a rapid reduction in proteinuria. Using immunoadsorption to reduce THSD7A antibodies led to a rapid reduction in proteinuria in 2 patients with THSD7A antibody-positive membranous nephropathy. Moreover, our findings support and strengthen the pathogenic role of the antibodies in the development of nephrotic syndrome in patients with THSD7A antibody-positive membranous nephropathy...
August 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31447072/an-implanted-blood-vessel-support-device-for-arteriovenous-fistulas-a-randomized-controlled-trial
#16
Nikolaos Karydis, Paul Bevis, Timothy Beckitt, Daniel Silverberg, Moshe Halak, Francis Calder
RATIONALE & OBJECTIVE: Reducing turbulent blood flow through dialysis arteriovenous fistulas (AVFs) and radial stretching of their venous wall may attenuate hyperplasia and stenosis and improve AVF outcomes in hemodialysis patients. The goal of this study was to evaluate the safety and efficacy of the VasQ implant, which intervenes on these mechanisms by physically supporting the surgical arteriovenous anastomosis. STUDY DESIGN: Prospective, randomized, controlled, multicenter study...
August 22, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31466738/urinary-concentration-capacity-glomerular-filtration-rate-and-mortality-in-the-general-american-population
#17
LETTER
Jacob J E Koopman
No abstract text is available yet for this article.
August 21, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31466737/in-reply-to-urinary-concentration-capacity-glomerular-filtration-rate-and-mortality-in-the-general-american-population
#18
LETTER
Nahid Tabibzadeh, Bénédicte Stengel, Jean-Philippe Haymann
No abstract text is available yet for this article.
August 21, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31445926/single-measurements-of-carboxy-terminal-fibroblast-growth-factor-23-and-clinical-risk-prediction-of-adverse-outcomes-in-ckd
#19
Daniel Edmonston, Daniel Wojdyla, Rupal Mehta, Xuan Cai, Claudia Lora, Debbie Cohen, Raymond R Townsend, Jiang He, Alan S Go, John Kusek, Matthew R Weir, Tamara Isakova, Michael Pencina, Myles Wolf
RATIONALE & OBJECTIVE: An elevated fibroblast growth factor 23 (FGF-23) level is independently associated with adverse outcomes in populations with chronic kidney disease, but it is unknown whether FGF-23 testing can improve clinical risk prediction in individuals. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Participants in the Chronic Renal Insufficiency Cohort (CRIC) Study (n = 3,789). EXPOSURE: Baseline carboxy-terminal FGF-23 (cFGF-23) level...
August 21, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31445925/straight-versus-coiled-peritoneal-dialysis-catheters-a-randomized-controlled-trial
#20
Kai Ming Chow, Steve Siu Man Wong, Jack Kit Chung Ng, Yuk Lun Cheng, Chi Bon Leung, Wing Fai Pang, Winston Wing Shing Fung, Cheuk Chun Szeto, Philip Kam Tao Li
RATIONALE & OBJECTIVE: Despite a recent meta-analysis favoring straight catheters, the clinical benefits of straight versus coiled peritoneal dialysis catheters remain uncertain. We conducted a randomized controlled study to compare the complication rates associated with these 2 types of double-cuffed peritoneal dialysis catheters. STUDY DESIGN: Multicenter, open-label, randomized, controlled trial. SETTING & PARTICIPANTS: 308 adult continuous ambulatory peritoneal dialysis patients...
August 21, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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