journal

American Journal of Kidney Diseases

journal
https://read.qxmd.com/read/31932094/peritoneal-dialysis-related-infection-rates-and-outcomes-results-from-the-peritoneal-dialysis-outcomes-and-practice-patterns-study-pdopps
#1
Jeffrey Perl, Douglas S Fuller, Brian A Bieber, Neil Boudville, Talerngsak Kanjanabuch, Yasuhiko Ito, Sharon J Nessim, Beth M Piraino, Ronald L Pisoni, Bruce M Robinson, Douglas E Schaubel, Martin J Schreiber, Isaac Teitelbaum, Graham Woodrow, Junhui Zhao, David W Johnson
RATIONALE & OBJECTIVE: Peritoneal dialysis (PD)-related peritonitis carries high morbidity for PD patients. Understanding the characteristics and risk factors for peritonitis can guide regional development of prevention strategies. We describe peritonitis rates and the associations of selected facility practices with peritonitis risk among countries participating in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). STUDY DESIGN: Observational prospective cohort study...
January 10, 2020: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31879216/comparability-of-plasma-iohexol-clearance-across-population-based-cohorts
#2
Bjørn O Eriksen, Elke Schaeffner, Toralf Melsom, Natalie Ebert, Markus van der Giet, Vilmundur Gudnason, Olafur S Indridasson, Amy B Karger, Andrew S Levey, Mirjam Schuchardt, Liv K Sørensen, Runolfur Palsson
RATIONALE & OBJECTIVE: Glomerular filtration rate (GFR) estimation based on creatinine or cystatin C level is currently the standard method for assessing GFR in epidemiologic research and clinical trials despite several important and well-known limitations. Plasma iohexol clearance has been proposed as an inexpensive method for measuring GFR that could replace estimated GFR in many research projects. However, lack of standardization for iohexol assays and the use of different protocols such as single- and multiple-sample methods could potentially hamper comparisons across studies...
December 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31879215/perceived-health-and-quality-of-life-in-patients-with-ckd-including-those-with-kidney-failure-findings-from-national-surveys-in-france
#3
Karine Legrand, Elodie Speyer, Bénédicte Stengel, Luc Frimat, Willy Ngueyon Sime, Ziad A Massy, Denis Fouque, Maurice Laville, Christian Combe, Christian Jacquelinet, Anne Claire Durand, Stéphane Edet, Stéphanie Gentile, Serge Briançon, Carole Ayav
RATIONALE & OBJECTIVE: Health-related quality of life (HRQoL) is a major outcome measure increasingly used in patients with chronic kidney disease (CKD). We evaluated the association between different stages of CKD and the physical and mental health domains of HRQoL. STUDY DESIGN: Cross-sectional study. SETTING & PARTICIPANTS: 2,693 outpatients with moderate (stage 3, estimated glomerular filtration rate [eGFR], 30-60mL/min/1.73m2 ) or advanced (stages 4-5, estimated glomerular filtration rate<30mL/min/1...
December 23, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31879218/peripheral-artery-disease-its-adverse-consequences-with-and-without-ckd
#4
Mathieu Bourrier, Thomas W Ferguson, John M Embil, Claudio Rigatto, Paul Komenda, Navdeep Tangri
RATIONALE & OBJECTIVES: Chronic kidney disease (CKD) is a potent risk factor for macrovascular disease and death. Peripheral artery disease (PAD) is more common in patients with CKD and is associated with lower-limb complications and mortality. We sought to compare the prevalence of PAD in and outside the setting of kidney disease and examine how PAD affects the risk for adverse health outcomes, specifically lower-limb complications, cardiovascular events, and survival. STUDY DESIGN: Retrospective cohort study...
December 19, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31879217/peripheral-artery-disease-in-ckd-anatomically-peripheral-but-clinically-central
#5
EDITORIAL
Manabu Hishida, Steven Menez, Kunihiro Matsushita
No abstract text is available yet for this article.
December 19, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31866229/moral-distress-in-nephrology-perceived-barriers-to-ethical-clinical-care
#6
Kathryn Ducharlet, Jennifer Philip, Hilton Gock, Mark Brown, Samantha L Gelfand, Elizabeth A Josland, Frank Brennan
Moral distress occurs when individuals are unable to act in accordance with what they believe to be ethically correct or just. It results from a discrepancy between a clinician's perception of "the right thing to do" and what is actually happening and is perpetuated by perceived constraints that limit the individual from speaking up or enacting change. Moral distress is reported by many clinicians in caring for patients with serious illness, including chronic kidney disease and kidney failure. If left unidentified, unexpressed, or unaddressed, moral distress may cause burnout, exhaustion, detachment, and ineffectiveness...
December 19, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31866228/chronic-microangiopathy-due-to-dcr-myc-a-myc-targeted-short-interfering-rna
#7
Aaron J Miller, Anthony Chang, Patrick N Cunningham
Thrombotic microangiopathy (TMA) is an emerging complication of oncologic therapy. Cancer-related causes of renal endothelial cell damage include cytotoxic chemotherapies, radiation given for myeloablation, and direct involvement of renal vasculature by tumor cells. Another class of therapeutic agents that has been implicated in TMA is the vascular endothelial growth factor (VEGF) pathway inhibitors, including the anti-VEGF monoclonal antibody bevacizumab and the VEGF receptor tyrosine kinase inhibitor sunitinib...
December 19, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31866227/does-vitamin-b-12-delay-ckd-progression
#8
EDITORIAL
Angela Yee-Moon Wang
No abstract text is available yet for this article.
December 19, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31866226/inflammation-and-response-to-sertraline-treatment-in-patients-with-ckd-and-major-depression
#9
LETTER
L Parker Gregg, Thomas Carmody, Dustin Le, Robert D Toto, Madhukar H Trivedi, S Susan Hedayati
No abstract text is available yet for this article.
December 19, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31866225/long-term-mortality-risks-among-living-kidney-donors-in-korea
#10
Yaerim Kim, Mi-Yeon Yu, Kyung Don Yoo, Chang Wook Jeong, Hyeon Hoe Kim, Sang-Il Min, Jongwon Ha, Yunhee Choi, Ah Ryoung Ko, Jae Moon Yun, Sang Min Park, Seung Hee Yang, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Curie Ahn, Yon Su Kim, Hajeong Lee
RATIONALE & OBJECTIVE: Living kidney donors may have a higher risk for death and kidney failure. This study aimed to investigate the long-term mortality experience of living kidney donors compared with members of the general public in Korea who underwent voluntary health examinations. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: We first calculated standardized mortality ratios for 1,292 Korean living kidney donors who underwent donor nephrectomy between 1982 and 2016 and 72,286 individuals who underwent voluntary health examinations between 1995 and 2016...
December 19, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31864822/serial-fibroblast-growth-factor-23-measurements-and-risk-of-requirement-for-kidney-replacement-therapy-the-cric-chronic-renal-insufficiency-cohort-study
#11
Rupal Mehta, Xuan Cai, Jungwha Lee, Dawei Xie, Xue Wang, Julia Scialla, Amanda H Anderson, Jon Taliercio, Mirela Dobre, Jing Chen, Michael Fischer, Mary Leonard, James Lash, Chi-Yuan Hsu, Ian H de Boer, Harold I Feldman, Myles Wolf, Tamara Isakova
RATIONALE & OBJECTIVE: Studies using a single measurement of fibroblast growth factor 23 (FGF-23) suggest that elevated FGF-23 levels are associated with increased risk for requirement for kidney replacement therapy (KRT) in patients with chronic kidney disease. However, the data do not account for changes in FGF-23 levels as kidney disease progresses. STUDY DESIGN: Case-cohort study. SETTING & PARTICIPANTS: To evaluate the association between serial FGF-23 levels and risk for requiring KRT, our primary analysis included 1,597 individuals in the Chronic Renal Insufficiency Cohort Study who had up to 5 annual measurements of carboxy-terminal FGF-23...
December 18, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31864821/myeloperoxidase-and-the-risk-of-ckd-progression-cardiovascular-disease-and-death-in-the-chronic-renal-insufficiency-cohort-cric-study
#12
Simon Correa, Jessy Korina Pena-Esparragoza, Katherine M Scovner, Sushrut S Waikar, Finnian R Mc Causland
BACKGROUND: Myeloperoxidase (MPO) catalyzes the formation of reactive nitrogen species and levels are elevated in patients with chronic kidney disease (CKD). Although increased oxidative stress and inflammation are associated with progression of CKD and cardiovascular disease (CVD), relationships between MPO concentration, CKD progression, CVD, and death remain unclear. STUDY DESIGN: Prospective cohort. SETTING & PARTICIPANTS: 3,872 participants from the Chronic Renal Insufficiency Cohort (CRIC) who had MPO measured at baseline...
December 18, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31862209/surgeon-characteristics-and-arteriovenous-fistula-maturation-success
#13
EDITORIAL
Thomas S Huber
No abstract text is available yet for this article.
December 17, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31843236/us-trends-in-hospitalizations-for-dialysis-requiring-acute-kidney-injury-in-people-with-versus-without-diabetes
#14
Jessica Lee Harding, Yanfeng Li, Nilka Ríos Burrows, Kai McKeever Bullard, Meda E Pavkov
RATIONALE & OBJECTIVE: Dialysis-requiring acute kidney injury (AKI-D) has increased substantially in the United States. We examined trends in and comorbid conditions associated with hospitalizations and in-hospital mortality in the setting of AKI-D among people with versus without diabetes. STUDY DESIGN: Cross-sectional study. SETTING & PARTICIPANTS: Nationally representative data from the National Inpatient Sample and National Health Interview Survey were used to generate 16 cross-sectional samples of US adults (aged ≥18 years) between 2000 and 2015...
December 13, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31839348/are-dialysis-facility-quality-incentive-program-scores-associated-with-patient-survival
#15
EDITORIAL
Nupur Gupta, Jay B Wish
No abstract text is available yet for this article.
December 13, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31837887/association-between-apol1-genotype-and-need-for-kidney-replacement-therapy-in-patients-without-diabetes-does-age-matter
#16
LETTER
Jenny Wei, Kirsten L Johansen, Charles E McCulloch, Michael Lipkowitz, Matthew Weir, Feng Lin, Vito M Campese, Miroslaw Smogorzewski, Elaine Ku
No abstract text is available yet for this article.
December 11, 2019: American Journal of Kidney Diseases
https://read.qxmd.com/read/31813664/effectiveness-of-influenza-vaccination-among-older-adults-across-kidney-function-pooled-analysis-of-2005-2006-through-2014-2015-influenza-seasons
#17
Junichi Ishigami, Yingying Sang, Morgan E Grams, Josef Coresh, Alex Chang, Kunihiro Matsushita
RATIONALE & OBJECTIVE: Influenza vaccination is recommended for all adults but particularly for older adults and those with high-risk conditions. Reduced kidney function is an important high-risk condition, but the effectiveness of influenza vaccination across kidney function is uncharacterized. We assessed the effectiveness of influenza vaccination among older adults with and without reduced kidney function. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 454,634 person-seasons among 110,968 individuals 65 years or older in the Geisinger Health System between the 2005 and 2015 influenza seasons, with baseline characteristics matched between those with and without vaccination using inverse probability weighting...
December 6, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31864820/blood-pressure-measurement-a-kdoqi-perspective
#18
Paul E Drawz, Srinivasan Beddhu, Holly J Kramer, Michael Rakotz, Michael V Rocco, Paul K Whelton
The majority of patients with chronic kidney disease (CKD) have elevated blood pressure (BP). In patients with CKD, hypertension is associated with increased risk for cardiovascular disease, progression of CKD, and all-cause mortality. New guidelines from the American College of Cardiology/American Heart Association (ACC/AHA) recommend new thresholds and targets for the diagnosis and treatment of hypertension in patients with and without CKD. A new aspect of the guidelines is the recommendation for measurement of out-of-office BP to confirm the diagnosis of hypertension and guide therapy...
December 5, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31813665/ultrafiltration-rate-residual-kidney-function-and-survival-among-patients-treated-with-reduced-frequency-hemodialysis
#19
Yu-Ji Lee, Yusuke Okuda, John Sy, Yong Kyu Lee, Yoshitsugu Obi, Seong Cho, Joline L T Chen, Anna Jin, Connie M Rhee, Kamyar Kalantar-Zadeh, Elani Streja
RATIONALE & OBJECTIVE: Patients receiving twice-weekly or less-frequent hemodialysis (HD) may need to undergo higher ultrafiltration rates (UFRs) to maintain acceptable fluid balance. We hypothesized that higher UFRs are associated with faster decline in residual kidney function (RKF) and a higher rate of mortality. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: 1,524 patients with kidney failure who initiated maintenance HD at a frequency of twice or less per week for at least 6 consecutive weeks at some time between 2007 and 2011 and for whom baseline data for UFR and renal urea clearance were available...
December 5, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/31812448/outcomes-from-right-versus-left-deceased-donor-kidney-transplants-a-us-national-cohort-study
#20
Sanjay Kulkarni, Guo Wei, Wei Jiang, Licia A Lopez, Chirag R Parikh, Isaac E Hall
RATIONALE & OBJECTIVE: There may be important transplant-related differences between right and left kidneys, including logistical/surgical considerations about vessel length for the right compared to the left kidney from the same donor. Because US centers choose between the right and left kidney when their recipient is ranked higher on a "match-run," we sought to determine whether deceased-donor right kidneys have had worse posttransplantation outcomes than left kidneys...
December 5, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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