journal
Journals International Journal of Molec...

International Journal of Molecular Sciences

https://read.qxmd.com/read/37686473/interaction-of-nanomaterials-with-cells-and-tissues
#1
EDITORIAL
Peter Veranič, Igor Križaj
Nanomaterials have gained enormous importance in biomedicine in recent years, both in basic and applied sciences [...].
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686472/specific-targeting-of-stat3-in-b-cells-suppresses-progression-of-b-cell-lymphoma
#2
JOURNAL ARTICLE
Lipei Wang, Mingqian Zhou, Xiangyu Kong, Shouzhen Wu, Chuanlin Ding, Xiaoling Hu, Haixun Guo, Jun Yan
The signal transducer and activator of transcription 3 ( STAT3 ), which regulates multiple oncogenic processes, has been found to be constitutively activated in lymphoma, suggesting its potential as a therapeutic target. Here, we constructed an anti-CD19-N-(4-carboxycyclohexylmethyl) maleimide N-hydroxysuccinimide ester (SMCC)-protamine (CSP)- STAT3 small interfering RNA (siRNA) conjugate and demonstrated that the CSP- STAT3 siRNA conjugate could specifically bind to normal B cells and A20 lymphoma cells in vitro...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686471/labeling-and-tracking-of-individual-human-mesenchymal-stromal-cells-using-photoconvertible-fluorescent-microcapsules
#3
JOURNAL ARTICLE
Olga A Sindeeva, Polina A Demina, Zhanna V Kozyreva, Albert R Muslimov, Olga I Gusliakova, Valeriia O Laushkina, Ekaterina A Mordovina, Daria Tsyupka, Olga S Epifanovskaya, Anastasiia Yu Sapach, Irina Yu Goryacheva, Gleb B Sukhorukov
The behavior and migration of human mesenchymal stromal cells (hMSCs) are focal points of research in the biomedical field. One of the major aspects is potential therapy using hMCS, but at present, the safety of their use is still controversial owing to limited data on changes that occur with hMSCs in the long term. Fluorescent photoconvertible proteins are intensively used today as "gold standard" to mark the individual cells and study single-cell interactions, migration processes, and the formation of pure lines...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686470/easy-and-versatile-technique-for-the-preparation-of-stable-and-active-lipase-based-clea-like-copolymers-by-using-two-homofunctional-cross-linking-agents-application-to-the-preparation-of-enantiopure-ibuprofen
#4
JOURNAL ARTICLE
Oussama Khiari, Nassima Bouzemi, José María Sánchez-Montero, Andrés R Alcántara
An easy and versatile method was designed and applied successfully to obtain access to lipase-based cross-linked-enzyme aggregate-like copolymers (CLEA-LCs) using one-pot, consecutive cross-linking steps using two types of homobifunctional cross-linkers (glutaraldehyde and putrescine), mediated with amine activation through pH alteration (pH jump) as a key step in the process. Six lipases were utilised in order to assess the effectiveness of the technique, in terms of immobilization yields, hydrolytic activities, thermal stability and application in kinetic resolution...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686469/molecular-regulatory-network-of-anthocyanin-accumulation-in-black-radish-skin-as-revealed-by-transcriptome-and-metabonome-analysis
#5
JOURNAL ARTICLE
Jing Zhang, Zi-Xuan Zhang, Bo-Yue Wen, Ya-Jie Jiang, Xia He, Rui Bai, Xin-Ling Zhang, Wen-Chen Chai, Xiao-Yong Xu, Jin Xu, Lei-Ping Hou, Mei-Lan Li
To understand the coloring mechanism in black radish, the integrated metabolome and transcriptome analyses of root skin from a black recombinant inbred line (RIL 1901) and a white RIL (RIL 1911) were carried out. A total of 172 flavonoids were detected, and the analysis results revealed that there were 12 flavonoid metabolites in radish root skin, including flavonols, flavones, and anthocyanins. The relative concentrations of most flavonoids in RIL 1901 were higher than those in RIL 1911. Meanwhile, the radish root skin also contained 16 types of anthocyanins, 12 of which were cyanidin and its derivatives, and the concentration of cyanidin 3-o-glucoside was very high at different development stages of black radish...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686468/foxo3-modulates-circadian-rhythms-in-neural-stem-cells
#6
JOURNAL ARTICLE
Swip Draijer, Raissa Timmerman, Jesse Pannekeet, Alexandra van Harten, Elham Aida Farshadi, Julius Kemmer, Demy van Gilst, Inês Chaves, Marco F M Hoekman
Both FoxO transcription factors and the circadian clock act on the interface of metabolism and cell cycle regulation and are important regulators of cellular stress and stem cell homeostasis. Importantly, FoxO3 preserves the adult neural stem cell population by regulating cell cycle and cellular metabolism and has been shown to regulate circadian rhythms in the liver. However, whether FoxO3 is a regulator of circadian rhythms in neural stem cells remains unknown. Here, we show that loss of FoxO3 disrupts circadian rhythmicity in cultures of neural stem cells, an effect that is mediated via regulation of Clock transcriptional levels...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686467/inhibition-of-notch-signaling-enhances-antitumor-activity-of-histone-deacetylase-inhibitor-laq824
#7
JOURNAL ARTICLE
Qinglang Mei, Xiaohan Xu, Danling Gao, Yuting Xu, Jinbo Yang
As a novel histone deacetylase inhibitor (HDACi), LAQ824 (LAQ) effectively inhibits the proliferation of hematological malignancies and solid tumors. However, phase II trials of LAQ in solid tumors were terminated due to dose-dependent toxicity. Furthermore, LAQ has been shown to induce the activation of the Notch signaling pathway in hematopoietic stem cells, which is associated with tumor progression and drug resistance in colon and breast cancers. Therefore, in this study, we investigated the strategy of LAQ combined with a Notch signaling pathway inhibitor to treat solid tumors...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686466/meiotic-cell-cycle-progression-in-mouse-oocytes-role-of-cyclins
#8
REVIEW
Hye Min Kim, Min Kook Kang, Se Yoon Seong, Jun Hyeon Jo, Min Ju Kim, Eun Kyeong Shin, Chang Geun Lee, Seung Jin Han
All eukaryotic cells, including oocytes, utilize an engine called cyclin-dependent kinase (Cdk) to drive the cell cycle. Cdks are activated by a co-factor called cyclin, which regulates their activity. The key Cdk-cyclin complex that regulates the oocyte cell cycle is known as Cdk1-cyclin B1. Recent studies have elucidated the roles of other cyclins, such as B2, B3, A2, and O, in oocyte cell cycle regulation. This review aims to discuss the recently discovered roles of various cyclins in mouse oocyte cell cycle regulation in accordance with the sequential progression of the cell cycle...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686465/mitogen-activated-protein-kinase-and-nuclear-hormone-receptor-crosstalk-in-cancer-immunotherapy
#9
REVIEW
Elke Burgermeister
The three major MAP-kinase (MAPK) pathways, ERK1/2, p38 and JNK/SAPK, are upstream regulators of the nuclear "hormone" receptor superfamily (NHRSF), with a prime example given by the estrogen receptor in breast cancer. These ligand-activated transcription factors exert non-genomic and genomic functions, where they are either post-translationally modified by phosphorylation or directly interact with components of the MAPK pathways, events that govern their transcriptional activity towards target genes involved in cell differentiation, proliferation, metabolism and host immunity...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686464/genome-wide-analysis-of-spl-mir156-module-and-its-expression-analysis-in-vegetative-and-reproductive-organs-of-oil-palm-elaeis-guineensis
#10
JOURNAL ARTICLE
Lixia Zhou, Rajesh Yarra
The SPL (SQUAMOSA-promoter binding protein-like) gene family is one of the largest plant transcription factors and is known to be involved in the regulation of plant growth, development, and stress responses. The genome-wide analysis of SPL gene members in a diverse range of crops has been elucidated. However, none of the genome-wide studies on the SPL gene family have been carried out for oil palm, an important oil-yielding plant. In this research, a total of 24 EgSPL genes were identified via a genome-wide approach...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686463/exploring-plasma-level-gut-microbiota-mediators-and-pro-inflammatory-markers-in-pregnant-women-with-short-cervix-and-gestational-diabetes-mellitus
#11
JOURNAL ARTICLE
Angela Silvano, Elena Niccolai, Simone Baldi, Viola Seravalli, Noemi Strambi, Giulia Nannini, Marco Pallecchi, Gianluca Bartolucci, Astrid Parenti, Amedeo Amedei, Mariarosaria Di Tommaso
The composition of the gut microbiota (GM) undergoes significant changes during pregnancy, influenced by metabolic status, energy homeostasis, fat storage, and hormonal and immunological modifications. Moreover, dysbiosis during pregnancy has been associated with preterm birth, which is influenced by factors such as cervical shortening, infection, inflammation, and oxidative stress. However, dysbiosis also affects the levels of lipopolysaccharide-binding protein (LBP), short-chain fatty acids (SCFAs), and free fatty acids (FFA) in other tissues and the bloodstream...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686462/salivary-chemical-barrier-proteins-in-oral-squamous-cell-carcinoma-alterations-in-the-defense-mechanism-of-the-oral-cavity
#12
JOURNAL ARTICLE
Gergő Kalló, Petra Magdolna Bertalan, Ildikó Márton, Csongor Kiss, Éva Csősz
Oral squamous cell carcinoma (OSCC) is one of the most frequent types of head and neck cancer. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serves as the chemical barrier of the oral cavity and, since OSCC can alter the protein composition of saliva, our aim was to analyze the effect of OSCC on the salivary chemical barrier proteins. Publicly available datasets regarding the analysis of salivary proteins from patients with OSCC and controls were collected and examined in order to identify differentially expressed chemical barrier proteins...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686461/mitochondrial-factors-in-the-cell-nucleus
#13
REVIEW
Katiuska González-Arzola, Antonio Díaz-Quintana
The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene transfer from the original proteobacterium to the host nucleus. Thus, mitochondrial performance relies on a mosaic of nuclear gene products from a variety of genomes. The concerted regulation of their synthesis is necessary for metabolic housekeeping and stress response. This governance involves crosstalk between mitochondrial, cytoplasmic, and nuclear factors. While anterograde and retrograde regulation preserve mitochondrial homeostasis, the mitochondria can modulate a wide set of nuclear genes in response to an extensive variety of conditions, whose response mechanisms often merge...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686460/chromosomal-rearrangements-and-satellite-dnas-extensive-chromosome-reshuffling-and-the-evolution-of-neo-sex-chromosomes-in-the-genus-pyrrhulina-teleostei-characiformes
#14
JOURNAL ARTICLE
Renata Luiza Rosa de Moraes, Francisco de Menezes Cavalcante Sassi, Jhon Alex Dziechciarz Vidal, Caio Augusto Gomes Goes, Rodrigo Zeni Dos Santos, José Henrique Forte Stornioli, Fábio Porto-Foresti, Thomas Liehr, Ricardo Utsunomia, Marcelo de Bello Cioffi
Chromosomal rearrangements play a significant role in the evolution of fish genomes, being important forces in the rise of multiple sex chromosomes and in speciation events. Repetitive DNAs constitute a major component of the genome and are frequently found in heterochromatic regions, where satellite DNA sequences (satDNAs) usually represent their main components. In this work, we investigated the association of satDNAs with chromosome-shuffling events, as well as their potential relevance in both sex and karyotype evolution, using the well-known Pyrrhulina fish model...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686459/in-vitro-embryogenesis-and-gastrulation-using-stem-cells-in-mice-and-humans
#15
REVIEW
Seung Yeon Oh, Seung Bin Na, Yoo Kyung Kang, Jeong Tae Do
During early mammalian embryonic development, fertilized one-cell embryos develop into pre-implantation blastocysts and subsequently establish three germ layers through gastrulation during post-implantation development. In recent years, stem cells have emerged as a powerful tool to study embryogenesis and gastrulation without the need for eggs, allowing for the generation of embryo-like structures known as synthetic embryos or embryoids. These in vitro models closely resemble early embryos in terms of morphology and gene expression and provide a faithful recapitulation of early pre- and post-implantation embryonic development...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686458/pharmacological-inhibition-and-genetic-deletion-of-cystathionine-gamma-lyase-in-mice-protects-against-organ-injury-in-sepsis-a-key-role-of-adhesion-molecules-on-endothelial-cells
#16
JOURNAL ARTICLE
Sumeet Manandhar, Stephen Chambers, Andrew Miller, Isao Ishii, Madhav Bhatia
Hydrogen sulfide (H2 S), synthesized by cystathionine gamma-lyase (Cth), contributes to the inflammatory response observed in sepsis. This study examines the effect of Cth-derived H2 S in adhesion molecules on endothelial cells of vital organs in mice in a cecal ligation puncture (CLP)-induced model of sepsis, using two different and complementary approaches: Cth gene deletion and pharmacological inhibition. Our findings revealed a decreased level of H2 S-synthesizing activity (via Cth) in both Cth-/- mice and PAG-treated wild-type (WT) mice following CLP-induced sepsis...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686457/establishing-functional-retina-in-a-dish-progress-and-promises-of-induced-pluripotent-stem-cell-based-retinal-neuron-differentiation
#17
REVIEW
Nonthaphat Kent Wong, Shea Ping Yip, Chien-Ling Huang
The human eye plays a critical role in vision perception, but various retinal degenerative diseases such as retinitis pigmentosa (RP), glaucoma, and age-related macular degeneration (AMD) can lead to vision loss or blindness. Although progress has been made in understanding retinal development and in clinical research, current treatments remain inadequate for curing or reversing these degenerative conditions. Animal models have limited relevance to humans, and obtaining human eye tissue samples is challenging due to ethical and legal considerations...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686456/development-of-multiplex-polymerase-chain-reaction-pcr-based-msa-assay-for-bladder-cancer-detection
#18
JOURNAL ARTICLE
Thomas Reynolds, Maxie Gordon, Gabriela Vanessa Flores Monar, David Moon, Chulso Moon
Several studies have shown that microsatellite changes can be profiled in the urine to detect bladder cancer. Microsatellite analysis (MSA) of bladder cancer detection requires a comprehensive analysis of up to 15-20 markers based on amplifying and interpreting many individual MSA markers, which can be technically challenging. To develop fast, efficient, standardized, and less costly MSA to detect bladder cancer, we developed three multiplex polymerase chain reaction (PCR) based MSA assays, all of which were analyzed by a genetic analyzer...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686455/imprinted-long-non-coding-rnas-in-mammalian-development-and-disease
#19
REVIEW
Flavio Di Michele, Isabel Chillón, Robert Feil
Imprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in cis the expression of protein-coding genes, often developmentally regulated. Some imprinted lncRNAs act in trans as well, controlling target gene expression elsewhere in the genome. The regulation of imprinted gene expression-including that of imprinted lncRNAs-is susceptible to stochastic and environmentally triggered epigenetic changes in the early embryo...
September 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686454/hla-class-i-expression-is-associated-with-dna-damage-and-immune-cell-infiltration-into-dysplastic-and-neoplastic-lesions-in-ulcerative-colitis
#20
JOURNAL ARTICLE
Haruka Okami, Naoya Ozawa, Makoto Sohda, Takehiko Yokobori, Katsuya Osone, Bilguun Erkhem-Ochir, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Tatsuya Miyazaki, Hiroomi Ogawa, Takashi Yao, Takahiro Oike, Hiro Sato, Ken Shirabe, Atsushi Shibata, Hiroshi Saeki
Human leukocyte antigen class I (HLA-I) is considered a genetic pathogen for ulcerative colitis (UC). This study aimed to investigate the significance of DNA damage and HLA-I expression in infiltrating immune cells and immune checkpoint protein PD-L1 expression in dysplasia/colitic cancer (CC) and sporadic colorectal cancer (SCRC). We performed immunohistochemical staining for HLA-I, PD-L1, γH2AX (DNA damage marker), and immune cell markers such as CD8, FOXP3, CD68, and CD163 (in surgically resected specimens from 17 SCRC patients with 12 adjacent normal mucosa (NM) and 9 UC patients with 18 dysplasia/CC tumors...
September 4, 2023: International Journal of Molecular Sciences
journal
journal
39474
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.