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European Journal of Clinical Pharmacology

https://read.qxmd.com/read/38647703/inconclusiveness-of-psychometric-testing-of-medication-adherence-questionnaires
#1
JOURNAL ARTICLE
Isabelle Arnet, Christiane Eickhoff, Laura J Sahm, Sabine Caloz, Michael Mittag, Martin Schulz, Samuel S Allemann
PURPOSE: To propose a paradigm change for the validation procedures of medication adherence questionnaires. METHODS: A total of 121 validation procedures of unique questionnaires for medication adherence were analyzed. RESULTS: "Construct validity" and "internal consistency" were most often assessed, and test results varied largely. A more in-depth analysis indicated that the assessment of medication non-adherence included distinct but related constructs, such as the extent to which doses are missed, and the attempt to identify different facets of medication-taking behavior...
April 22, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38639762/effect-of-propranolol-on-pharmacokinetics-of-clozapine-in-schizophrenic-patients-a-meta-analysis
#2
JOURNAL ARTICLE
Xiding Yang, Qiangyong Yan, Lingfeng Yang, Jingjing Li, Xiao Fan, Jindong Chen, Haishan Wu, Yongyu Yang, Ronghua Zhu, Pingfei Fang
PURPOSE: Clozapine is the effective therapy for treatment-refractory schizophrenia. However, the use of clozapine is limited by its adverse effects. As propranolol is frequently used for the prevention and treatment of clozapine-induced tachycardia, we performed a meta-analysis to evaluate the effects of propranolol on steady state pharmacokinetics of clozapine in schizophrenic patients. METHODS: We included 16 retrospective studies on the effects of propranolol on steady state pharmacokinetics of clozapine in schizophrenic patients, with data from both generic and brand name treatment phases in eight clozapine bioequivalence studies conducted in a single center in China from 2018 to 2022...
April 19, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38630193/medication-use-before-and-during-pregnancy-in-japan-the-tohoku-medical-megabank-project-birth-and-three-generation-cohort-study
#3
JOURNAL ARTICLE
Aoi Noda, Taku Obara, Matsuyuki Shirota, Fumihiko Ueno, Fumiko Matsuzaki, Rieko Hatanaka, Ryo Obara, Kei Morishita, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Shinichi Kuriyama
PURPOSE: To elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: Questionnaires were distributed to pregnant women participating in the TMM BirThree Cohort Study (from July 2013 to March 2017) around 12 weeks (early pregnancy) and 26 weeks (middle pregnancy). We analysed medication use over three periods: (1) 12 months prior to pregnancy diagnosis, (2) the period between pregnancy diagnosis and around week 12 of pregnancy, and (3) post around week 12 of pregnancy...
April 17, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38607390/albumin-a-comprehensive-review-and-practical-guideline-for-clinical-use
#4
JOURNAL ARTICLE
Farshad Abedi, Batool Zarei, Sepideh Elyasi
PURPOSE: Nowadays, it is largely accepted that albumin should not be used in hypoalbuminemia or for nutritional purpose. The most discussed indication of albumin at present is the resuscitation in shock states, especially distributive shocks such as septic shock. The main evidence-based indication is also liver disease. In this review, we provided updated evidence-based instruction for definite and potential indications of albumin administration in clinical practice, with appropriate dosing and duration...
April 12, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38605248/efficacy-and-safety-of-dabigatran-and-rivaroxaban-in-atrial-fibrillation-patients-with-impaired-liver-function-a-multicenter-retrospective-cohort-study
#5
JOURNAL ARTICLE
Xinhai Huang, Wenlin Xu, Guilan Wu, Ruijuan Li, Ping Gu, Qiaowei Zheng, Xiumei Liu, Hengfen Dai, Xiangsheng Lin, Yuxin Liu, Xiaoming Du, Jun Su, Wang Zhang, Min Zhang, Zhu Zhu, Xiaohong Huang, Nianxu Huang, Jinhua Zhang
BACKGROUND: The efficacy and safety of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) patients with impaired liver function (ILF) have not been sufficiently studied. The aim of this study was to evaluate the efficacy and safety of DOACs for stroke prevention in patients with AF and ILF. METHOD: This study was based on data from 15 centers in China, including 4,982 AF patients. The patients were divided into 2 subgroups based on their liver function status: patients with normal liver function (NLF)(n = 4213) and patients with ILF (n = 769)...
April 12, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38597935/sacubitril-valsartan-compared-to-equivalent-sub-equivalent-dose-angiotensin-receptor-blocker-or-angiotensin-converting-enzyme-inhibitor-in-heart-failure-with-reduced-ejection-fraction-a-meta-analysis-of-randomized-trials
#6
REVIEW
Joseph P Rindone, Chadwick K Mellen
PURPOSE: The objective of this meta-analysis is to determine how sacubitril/valsartan (SV) compares to equivalent and sub-equivalent angiotensin receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI) in patients with heart failure with reduced ejection fraction (HFrEF). METHODS: The databases of PubMed and EMBASE were used to identify those randomized controlled trials which compared SV to ARB/ACEI in patients with HFrEF. Only those trials that reported outcomes regarding total mortality, cardiovascular mortality, and worsening heart failure were considered...
April 10, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38592471/paving-the-way-towards-medicines-for-women-and-men
#7
REVIEW
Rita Banzi, Silvio Garattini
No abstract text is available yet for this article.
April 9, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38592470/poor-performance-of-chatgpt-in-clinical-rule-guided-dose-interventions-in-hospitalized-patients-with-renal-dysfunction
#8
JOURNAL ARTICLE
Merel van Nuland, JaapJan D Snoep, Toine Egberts, Abdullah Erdogan, Ricky Wassink, Paul D van der Linden
PURPOSE: Clinical decision support systems (CDSS) are used to identify drugs with potential need for dose modification in patients with renal impairment. ChatGPT holds the potential to be integrated in the electronic health record (EHR) system to give such dosing advices. In this study, we aim to evaluate the performance of ChatGPT in clinical rule-guided dose interventions in hospitalized patients with renal impairment. METHODS: This cross-sectional study was performed at Tergooi Medical Center, the Netherlands...
April 9, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38589523/chatgpt-for-generating-multiple-choice-questions-comment
#9
LETTER
Hineptch Daungsupawong, Viroj Wiwanitkit
No abstract text is available yet for this article.
April 9, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38565697/-always-look-at-the-outliers-in-memoriam-leif-bertilsson
#10
LETTER
Julia Stingl, Eleni Aklillu, Collen Masimirembwa, Teh Lay Kek
No abstract text is available yet for this article.
April 3, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38558317/comparing-the-effect-of-fluoxetine-escitalopram-and-sertraline-on-the-level-of-bdnf-and-depression-in-preclinical-and-clinical-studies-a-systematic-review
#11
REVIEW
Nastaran Talaee, Shataw Azadvar, Sanaz Khodadadi, Nahal Abbasi, Zahra Najafi Asli-Pashaki, Yasaman Mirabzadeh, Gita Kholghi, Shahin Akhondzadeh, Salar Vaseghi
Brain-derived neurotrophic factor (BDNF) dysfunction is one of the most important mechanisms underlying depression. It seems that selective serotonin reuptake inhibitors (SSRIs) improve depression via affecting BDNF level. In this systematic review, for the first time, we aimed to review the effect of three SSRIs including fluoxetine, escitalopram, and sertraline, on both depression and BDNF level in preclinical and clinical studies. PubMed electronic database was searched, and 193 articles were included in this study...
April 1, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38554180/oral-contraceptives-in-adolescents-a-retrospective-population-based-study-on-blood-pressure-and-metabolic-dysregulation
#12
JOURNAL ARTICLE
Priscila Xavier de Araújo, Priscila Moreira, Danilo Candido de Almeida, Alexandra Aparecida de Souza, Maria do Carmo Franco
PURPOSE: This study aimed to explore the relationship between oral contraceptive use and blood pressure values and in a national cohort of women adolescents and to investigate the level of coexistence of the high blood pressure levels, dyslipidemia or insulin resistance. METHODS: This is a retrospective cohort study that evaluated data form 14,299 adolescents aged 14 to 17 years. Crude and race-and age-adjusted analyses were performed using Poisson regression to estimate the prevalence ratios...
March 30, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38554179/is-interventional-trial-a-correct-term-to-use-in-clinical-research
#13
LETTER
Rafael Dal-Ré
No abstract text is available yet for this article.
March 30, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38553558/high-refill-adherence-to-adalimumab-is-associated-with-low-disease-activity-in-patients-with-inflammatory-bowel-disease
#14
JOURNAL ARTICLE
Esma H San, Angelique Egberts, Caroline W Th van Dijck-van Boetzelaer, Rachel L West, Erwin C Vasbinder
PURPOSE: Adalimumab has evolved to one of the more affordable first-line biologics for the treatment of inflammatory bowel disease (IBD), since its patent expired. However, poor adherence to adalimumab is a concern and may limit its effectiveness. It is plausible that good adherence improves treatment outcomes in IBD patients, but evidence is scarce. The aim of this study was to assess whether high refill-adherence (medication possession ratio (MPR) ≥ 80%) to adalimumab is associated with less active disease in IBD patients...
March 30, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38546841/understanding-adefovir-pharmacokinetics-as-a-component-of-a-transporter-phenotyping-cocktail
#15
JOURNAL ARTICLE
Qian Dong, Chunli Chen, Max Taubert, Muhammad Bilal, Martina Kinzig, Fritz Sörgel, Oliver Scherf-Clavel, Uwe Fuhr, Charalambos Dokos
PURPOSE: Adefovir (as dipivoxil) was selected as a probe drug in a previous transporter cocktail phenotyping study to assess renal organic anion transporter 1 (OAT1), with renal clearance (CLR ) as the primary parameter describing renal elimination. An approximately 20% higher systemic exposure of adefovir was observed when combined with other cocktail components (metformin, sitagliptin, pitavastatin, and digoxin) compared to sole administration. The present evaluation applied a population pharmacokinetic (popPK) modeling approach to describe adefovir pharmacokinetics as a cocktail component in more detail...
March 28, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38546840/physicochemical-compatibility-of-caffeine-citrate-and-caffeine-base-injections-with-parenteral-medications-used-in-neonatal-intensive-care-settings
#16
JOURNAL ARTICLE
D Thisuri N De Silva, Michael Petrovski, Tobias Strunk, Nabeelah Mukadam, Madhu Page-Sharp, Brioni R Moore, Kevin T Batty
PURPOSE: To investigate the physicochemical compatibility of caffeine citrate and caffeine base injections with 43 secondary intravenous (IV) drugs used in Neonatal Intensive Care Unit (NICU) settings. METHODS: Caffeine citrate (20 mg/mL or 10 mg/mL) or caffeine base injection (10 mg/mL) were mixed in a volume ratio of 1:1 with the secondary drug solution to simulate Y-site co-administration procedures in NICUs. Physical compatibility was evaluated based on visual observation for 2 h, against a black and white background and under polarised light, for changes in colour, precipitation, haze and evolution of gas...
March 28, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38536419/failure-to-reduce-benzodiazepine-prescriptions-through-the-implementation-of-a-psychological-intervention-for-insomnia-in-an-italian-mental-health-service
#17
JOURNAL ARTICLE
Barbara D'Avanzo, Alberto Parabiaghi, Alessia A Galbussera, Mauro Tettamanti, Igor Monti, Luana Di Gregorio, Francesco Zambello, Marco Maria Goglio, Elisabetta Recla, Wilma Angela Di Napoli, Angelo Barbato
PURPOSE: Despite the evidence of higher effectiveness of psychological interventions for insomnia compared to pharmacological ones, drug prescriptions for insomnia remain frequent. This study has assessed patterns of prescriptions of BZDs for insomnia before and after the delivery of a training in psychological interventions to professionals working in the services of a Department of Mental Health in northern Italy. METHODS: The intervention consisted in two training sessions about psychological interventions for insomnia delivered to professionals of the participating services...
March 27, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38536418/imatinib-pharmacokinetics-and-creatine-kinase-levels-in-chronic-myeloid-leukemia-patients-implications-for-therapeutic-response-and-monitoring
#18
JOURNAL ARTICLE
Mervat M Omran, Amel B Ibrahim, Raafat Abdelfattah, Samia A Shouman, Marwa S Hamza
BACKGROUND: Imatinib treatment for certain cancers can lead to elevated creatine kinase (CK) levels, potentially indicating muscle injury, and ongoing research aims to understand the correlation between imatinib levels and creatine kinase to assess its impact on treatment response. METHODS: This single-center observational study involved 76 chronic myeloid leukemia (CML) patients receiving imatinib treatment, focusing on evaluating drug and metabolite levels using liquid chromatography-mass spectrometry (LC-MS-MS) instrumentation...
March 27, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38526747/management-of-enzyme-de-induction-in-a-woman-with-hiv-on-methadone-maintenance-switched-from-nevirapine-to-bictegravir-based-antiretroviral-regimen
#19
LETTER
Dario Cattaneo, Andrea Giacomelli, Giacomo Casalini, Anna Lisa Ridolfo, Cristina Gervasoni
No abstract text is available yet for this article.
March 25, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38507060/factor-xa-inhibitors-versus-warfarin-in-patients-with-morbid-obesity-and-atrial-fibrillation
#20
JOURNAL ARTICLE
Paul Dobry, Kirsten McGrew, Ina Yun, Rebecca Heath, Amna Shafqat, Ascend-Higher, Christopher Giuliano
PURPOSE: Factor Xa Inhibitors have emerged as a first-line agent in the management of non-valvular atrial fibrillation (NVAF), but there is a need for additional data surrounding their use in the morbidly obese population. The purpose of this study was to evaluate whether Factor Xa Inhibitors are as safe and effective as warfarin for the treatment of NVAF in individuals with a BMI ≥ 40 kg/m2 and/or weight ≥ 120 kg. METHODS: This was a multi-center retrospective cohort study comparing the use of Factor Xa Inhibitors (apixaban and rivaroxaban) to warfarin for the management of NVAF in adult patients with a BMI ≥ 40 kg/m2 and/or weight ≥ 120 kg...
March 20, 2024: European Journal of Clinical Pharmacology
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