We have located links that may give you full text access.
Journal Article
Research Support, U.S. Gov't, P.H.S.
Altered renal vascular tone and plasma renin activity due to fastigial and baroreceptor activation.
American Journal of Physiology 1980 August
The effects of stimulating the cerebellar fastigial nucleus in altering renal vascular resistance were assessed at three levels of carotid sinus pressure (CSP). In alpha-chloralose-anesthetized, vagotomized, and salt-depleted cats, renal vascular resistance changes were established by perfusing the isolated carotid sinus at high (197 +/- 17 mmHg), medium (117 +/- 8 mmHg), and low (60 +/- 7 mmHg) pressure. The hemodynamic state of the perfused kidney was determined from flow-pressure curves. In relative units, the flow resistance in the renal bed was for low CSP, 2.60 PRU100, for medium CSP, 2.25 PRU100, and for high CSP, 1.22 PRU100. The fastigial pressor response was imposed at each flow-presure determination with or without superior cerebellar peduncle lesions. An increase in the resistance with the fastigial stimulation was noted at each of the three hemodynamic states; 14% at low, 26% at medium, and 22% at high CSP. With increased renal vascular resistance evoked through the baroreflex, there was an increase in plasma renin activity. The rise in plasma renin activity could be attributed in large part to an increase in sympathetic renal nerve activity wherein the fastigial pressor response shared a synergistic action at medium and high carotid sinus pressure. The effect of the fastigial stimulation on renal vascular resistance and renin secretion was abolished by transections of the superior cerebellar peduncles.
Full text links
Related Resources
Trending Papers
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.Mayo Clinic Proceedings 2024 April
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app