We have located links that may give you full text access.
Evaluation of bone marrow function with immature platelet fraction in normal pregnancy.
Pregnancy Hypertension 2017 October
BACKGROUND: Bone marrow function in pregnancy is influencing blood cell concentration of platelets. The steady state of consumption, recovery and production of platelets is essential for coagulation and bleeding prevention. Reticulated platelets are an intermediate form of thrombocytes during thrombopoiesis representing platelet production. The immature platelet fraction (IPF) represents these platelets as percentage of all thrombocytes. Until now, there is little knowledge on IPF during pregnancy.
MATERIAL AND METHODS: 69 healthy pregnant women were included in this monocentric study. Serial blood samples of 27 women (study group 1) and single blood samples of 42 women (study group 2) were taken between 20 and 40weeks of gestation. IPF levels and thrombocytes were quantified by a routine clinical hematology analyzer. Both two study groups were analyzed separately.
RESULTS: IPF levels increased between 20 and 40weeks of gestation in both study groups. Median absolute values of IPF increased from 8.1/nl to 13.6/nl in study group 1 and remained constant in study group 2. Values in percent rose from 3.63% to 6.06% in study group 1 and from 4.9% to 6.01% in study group 2. Most values stayed below 20/nl or 7-7.5%. Highest IPF levels were measured near term. In contrast, thrombocyte counts decrease slightly during this period.
CONCLUSION: Bone marrow function is mirrored by IPF levels, which increase with gestational age in healthy pregnant women. Most IPF values remain below 20/nl or 7%. More studies are needed to improve understanding of thrombocyte turnover in pregnancy.
MATERIAL AND METHODS: 69 healthy pregnant women were included in this monocentric study. Serial blood samples of 27 women (study group 1) and single blood samples of 42 women (study group 2) were taken between 20 and 40weeks of gestation. IPF levels and thrombocytes were quantified by a routine clinical hematology analyzer. Both two study groups were analyzed separately.
RESULTS: IPF levels increased between 20 and 40weeks of gestation in both study groups. Median absolute values of IPF increased from 8.1/nl to 13.6/nl in study group 1 and remained constant in study group 2. Values in percent rose from 3.63% to 6.06% in study group 1 and from 4.9% to 6.01% in study group 2. Most values stayed below 20/nl or 7-7.5%. Highest IPF levels were measured near term. In contrast, thrombocyte counts decrease slightly during this period.
CONCLUSION: Bone marrow function is mirrored by IPF levels, which increase with gestational age in healthy pregnant women. Most IPF values remain below 20/nl or 7%. More studies are needed to improve understanding of thrombocyte turnover in pregnancy.
Full text links
Related Resources
Trending Papers
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.Mayo Clinic Proceedings 2024 April
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app