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Journal Article
Research Support, Non-U.S. Gov't
Lifting the curtain on loop extrusion barriers: Single-molecule insights into cohesin stalling.
Molecular Cell 2023 August 18
In this issue, Zhang et al.1 show that CTCF blocks cohesin-mediated loop extrusion in an orientation-dependent manner. Using single-molecule imaging assays, the authors find that dCas9 and R-loops can also stall extrusion.
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