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JOURNAL ARTICLE
T Wesley Templeton, Bridget Krol, Scott Miller, Lisa K Lee, Mike Mathis, Susan R Vishneski, Debnath Chatterjee, Ruchika Gupta, Rebecca A Shroeder, Amit K Saha
BACKGROUND: Risk factors for hypoxemia in school age children undergoing one-lung ventilation remain poorly understood. We hypothesize that certain modifiable and non-modifiable factors may be associated with increased risk of hypoxemia in school age children undergoing one-lung ventilation and thoracic surgery. METHODS: The Multicenter Perioperative Outcomes Group database was queried for children 4 to 17 years of age undergoing one-lung ventilation. Patients undergoing vascular or cardiac procedures were excluded...
September 22, 2023: Anesthesiology
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JOURNAL ARTICLE
Haobo Ma, Elena Ahrens, Luca J Wachtendorf, Aiman Suleiman, Denys Shay, Ricardo Munoz-Acuna, Tim M Tartler, Bijan Teja, Soeren Wagner, Balachundhar Subramaniam, James Rhee, Maximilian S Schaefer
BACKGROUND: The treatment of intraoperative hypotension with phenylephrine may impair cerebral perfusion through vasoconstriction, which has been linked to postoperative delirium. We hypothesized that intraoperative administration of phenylephrine, compared to ephedrine, is associated with higher odds of postoperative delirium. METHODS: 103,094 hospitalized adults undergoing general anesthesia for non-cardiac, non-neurosurgical procedures between 2008 and 2020 at two tertiary academic healthcare networks in Massachusetts, USA were included in this multicenter hospital registry study...
September 19, 2023: Anesthesiology
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JOURNAL ARTICLE
Edita Navratilova, Chaoling Qu, Guangchen Ji, Volker Neugebauer, Miguel Guerrero, Hugh Rosen, Ed Roberts, Frank Porreca
BACKGROUND: The efficiency of descending pain modulation, commonly assessed with the conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain. We hypothesized that the efficiency of pain modulation is controlled by cortical opioid circuits. METHODS: We evaluated the effects of mu opioid receptor (MOR) activation in the anterior cingulate cortex (ACC) on descending control of nociception (DCN), a preclinical correlate of CPM, in male Sprague Dawley rats with spinal nerve ligation-induced chronic pain or in sham-operated controls...
September 19, 2023: Anesthesiology
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JOURNAL ARTICLE
Michael P Eaton, Sergiy M Nadtochiy, Ronald E Angona
No abstract text is available yet for this article.
September 19, 2023: Anesthesiology
#5
JOURNAL ARTICLE
Gabor Erdoes, Andreas Koster, Jerrold H Levy
No abstract text is available yet for this article.
September 19, 2023: Anesthesiology
#6
JOURNAL ARTICLE
Ethan Garrigan, Grace McCarthy, Russell J Krom, Yuriy S Bronshteyn
No abstract text is available yet for this article.
September 19, 2023: Anesthesiology
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JOURNAL ARTICLE
Pavel S Roshanov, Matthew T V Chan, Flavia K Borges, David Conen, C Y Wang, Denis Xavier, Otavio Berwanger, Maura Marcucci, Daniel I Sessler, Wojciech Szczeklik, Jessica Spence, Pablo Alonso-Coello, Carmen Fernández, Rupert M Pearse, German Malaga, Amit X Garg, Sadeesh K Srinathan, Michael J Jacka, Vikas Tandon, Michael McGillion, Ekaterine Popova, Alben Sigamani, Valsa Abraham, Bruce M Biccard, Juan Carlos Villar, Clara K Chow, Carísi A Polanczyk, Maria Tiboni, Richard Whitlock, Gareth L Ackland, Mohamed Panju, André Lamy, Robert Sapsford, Colin Williams, William Ka Kei Wu, Olga L Cortés, S Danielle MacNeil, Ameen Patel, Emilie P Belley-Côté, Sandra Ofori, William F McIntyre, Darryl P Leong, Diane Heels-Ansdell, Krysten Gregus, P J Devereaux
BACKGROUND: In prior analyses, myocardial injury after noncardiac surgery, major bleeding, and sepsis were independently associated with most deaths in the 30 days after noncardiac surgery, but most of these deaths occurred during the index hospitalization for surgery. We set out to describe outcomes after discharge from hospital up to one year after inpatient noncardiac surgery and associations between pre-discharge complications and post-discharge death up to one year after surgery...
September 15, 2023: Anesthesiology
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JOURNAL ARTICLE
Michael M Todd
No abstract text is available yet for this article.
September 14, 2023: Anesthesiology
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JOURNAL ARTICLE
Hee Jung Baik
No abstract text is available yet for this article.
September 14, 2023: Anesthesiology
#10
JOURNAL ARTICLE
Patrick Wong, Oliver Ashby
No abstract text is available yet for this article.
September 13, 2023: Anesthesiology
#11
JOURNAL ARTICLE
James Joseph Thomas
No abstract text is available yet for this article.
September 6, 2023: Anesthesiology
#12
JOURNAL ARTICLE
Allison L Thoeny
No abstract text is available yet for this article.
September 6, 2023: Anesthesiology
#13
JOURNAL ARTICLE
Takashi Asai
No abstract text is available yet for this article.
September 6, 2023: Anesthesiology
#14
JOURNAL ARTICLE
Yongchen Cui, Xiaofeng Wang, Yang Xu, Yue Cao, Gang Luo, Zhe Zhao, Junfeng Zhang
BACKGROUND: Continuous nerve block with ropivacaine is commonly performed after repair surgery for traumatic peripheral nerve injuries. After peripheral nerve injury, tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 is upregulated and contributes to macrophage inflammation. We investigated whether ropivacaine promotes peripheral nerve regeneration through Nav1.8-mediated macrophage signaling. METHODS: A sciatic nerve transection-repair (SNT) model was established in adult Sprague-Dawley rats of both sexes...
September 5, 2023: Anesthesiology
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JOURNAL ARTICLE
Fredrik Granholm, Derrick Tin, Leilani Doyle, Gregory Ciottone
During the last few decades, the increasing use of asymmetric and multimodal tactics by terrorists has led anesthesiologists worldwide to analyze and discuss their role in mass casualty scenarios in more depth. Now anesthesiologists must address the new situation of hybrid threats and hybrid warfare. This will have a direct impact on anesthesiology and intensive care, and in the end, the health and well-being of critical patients of all ages. To be able to respond to a hybrid threat efficiently and effectively, it is imperative that anesthesiologists play an early and integral role in mitigation and response planning...
September 4, 2023: Anesthesiology
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JOURNAL ARTICLE
Mattia Busana, Anna Rau, Stefano Lazzari, Simone Gattarello, Massimo Cressoni, Lorenz Biggemann, Lars-Olav Harnisch, Lorenzo Giosa, Andreas Vogt, Leif Saager, Joachim Lotz, Birgit Meller, Konrad Meissner, Luciano Gattinoni, Onnen Moerer
BACKGROUND: Despite the fervent scientific effort, a state-of-the art assessment of the different causes of hypoxemia (shunt, ventilation-perfusion mismatch and diffusion limitation) in COVID-19 ARDS is currently lacking. In this study we aimed to understand what is the relative contribution of the different mechanisms of hypoxemia in this disease and what is their relationship with the distribution of tissue and blood within the lung. METHODS: We prospectively enrolled 10 patients with COVID-19 ARDS, intubated for <7 days...
September 1, 2023: Anesthesiology
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JOURNAL ARTICLE
Laurence Moss, Hemme Hijma, Mark Demitrack, Jessica Kim, Geert Jan Groeneveld, Monique van Velzen, Marieke Niesters, Erik Olofsen, Albert Dahan
BACKGROUND: Oliceridine (Olinvyk®) is a μ-opioid receptor agonist that in contrast to conventional opioids preferentially engages the G-protein-coupled signaling pathway. We determined the utility function of oliceridine versus morphine based on neurocognitive tests and cold pressor test. METHODS: The study had a randomized, double-blind, placebo-controlled, partial block 3-way crossover design. Experiments were performed in 20 male and female volunteers...
September 1, 2023: Anesthesiology
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JOURNAL ARTICLE
Shuang Han, Bin Jiang, Jiale Ren, Feng Gao, Junjian Wen, Taihe Zhou, Laijian Wang, Xuhong Wei
BACKGROUND: Memory deficits are a common comorbid disorder in patients suffering from neuropathic pain. The mechanisms underlying the comorbidities remain elusive. We hypothesized that impaired lactate release from dysfunctional astrocytes in dorsal hippocampal CA1 contributed to memory deficits. METHODS: A spared nerve injury model was established to induce both pain and memory deficits in rats and mice of both sexes. Von Frey tests, novel object recognition and conditioned place preference tests were applied to evaluate the behaviors...
August 31, 2023: Anesthesiology
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JOURNAL ARTICLE
Jiabin Liu, Haoyan Zhong, Michael Reynolds, Alex Illescas, Crispiana Cozowicz, Christopher L Wu, Jashvant Poeran, Stavros Memtsoudis
BACKGROUND: Various studies have demonstrated racial disparities in perioperative care and outcomes. We hypothesize that among lower extremity total joint arthroplasty (TJA) patients, Evidence Based Perioperative Practice (EBPOP) utilization increased over time amongst all racial groups, and that standardized EBPOP care protocols resulted in reduction of racial disparities and improved outcomes. METHODS: We analyzed 3,356,805 lower extremity TJA patients from the Premier Healthcare database...
August 31, 2023: Anesthesiology
#20
JOURNAL ARTICLE
Charles F Minto, Talmage D Egan, Thomas W Schnider
No abstract text is available yet for this article.
August 31, 2023: Anesthesiology
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