Clemens Reiffurth, Nikolaus Berndt, Adrian Gonzalez Lopez, Karl Schoknecht, Richard Kovács, Mathilde Maechler, Mirja Grote Lambers, Jens P Dreier, Alon Friedman, Claudia Spies, Agustin Liotta
BACKGROUND: Maintenance of ion homeostasis is essential for normal brain function. Inhalational anesthetics are known to act on various receptors but their effects on ion homeostatic systems, such as the Na+/K+-ATPase, remain largely unexplored. Based on reports demonstrating global network activity and wakefulness modulation by interstitial ions, we hypothesized that deep isoflurane anesthesia affects ion homeostasis and the key mechanism for clearing extracellular K+, the Na+/K+-ATPase...
March 9, 2023: Anesthesiology