journal
https://read.qxmd.com/read/34330146/statistical-development-and-validation-of-clinical-prediction-models
#1
Steven J Staffa, David Zurakowski
Clinical prediction models in anesthesia and surgery research have many clinical applications including preoperative risk stratification with implications for clinical utility in decision-making, resource utilization, and costs. It is imperative that predictive algorithms and multivariable models are validated in a suitable and comprehensive way in order to establish the robustness of the model in terms of accuracy, predictive ability, reliability, and generalizability. The purpose of this article is to educate anesthesia researchers at an introductory level on important statistical concepts involved with development and validation of multivariable prediction models for a binary outcome...
July 30, 2021: Anesthesiology
https://read.qxmd.com/read/34329393/noninvasive-urine-oxygen-monitoring-and-the-risk-of-acute-kidney-injury-in-cardiac-surgery
#2
Natalie A Silverton, Lars R Lofgren, Isaac E Hall, Gregory J Stoddard, Natalia P Melendez, Michael Van Tienderen, Spencer Shumway, Bradley J Stringer, Woon-Seok Kang, Carter Lybbert, Kai Kuck
BACKGROUND: Acute kidney injury (AKI) is a common complication of cardiac surgery. An intraoperative monitor of kidney perfusion is needed to identify patients at risk for AKI. The authors created a noninvasive urinary oximeter that provides continuous measurements of urinary oxygen partial pressure and instantaneous urine flow. They hypothesized that intraoperative urinary oxygen partial pressure measurements are feasible with this prototype device and that low urinary oxygen partial pressure during cardiac surgery is associated with the subsequent development of AKI...
July 30, 2021: Anesthesiology
https://read.qxmd.com/read/34329391/could-trended-oxygen-partial-pressure-in-the-urine-be-the-st-segment-kidney-monitor-we-ve-been-looking-for
#3
Mark Stafford-Smith
No abstract text is available yet for this article.
July 30, 2021: Anesthesiology
https://read.qxmd.com/read/34329383/scientific-integrity-and-misconduct-yet-again
#4
Evan D Kharasch
No abstract text is available yet for this article.
July 30, 2021: Anesthesiology
https://read.qxmd.com/read/34329380/anesthesia-method-tourniquet-use-and-persistent-postsurgical-pain-after-total-knee-arthroplasty-a-prespecified-secondary-analysis-of-a-randomized-trial
#5
Riku A Palanne, Mikko T Rantasalo, Anne P Vakkuri, Rami Madanat, Klaus T Olkkola, Elina M Reponen, Rita Linko, Tero J Vahlberg, Noora K A Skants
BACKGROUND: Persistent postsurgical pain after total knee arthroplasty is a common problem and a major reason for patient dissatisfaction. This secondary analysis aimed to investigate the effects of anesthesia (spinal vs. general) and tourniquet use on persistent pain after total knee arthroplasty. METHODS: In this secondary analysis of a previously presented parallel, single-center, randomized trial, 404 patients scheduled for total knee arthroplasty were randomized to spinal versus general anesthesia and no-tourniquet versus tourniquet groups...
July 30, 2021: Anesthesiology
https://read.qxmd.com/read/34329373/does-divergence-exist-between-animal-and-human-data-on-the-effect-of-cebranopadol
#6
Albert Dahan, Erik Olofsen
No abstract text is available yet for this article.
July 30, 2021: Anesthesiology
https://read.qxmd.com/read/34329371/ipsilateral-and-simultaneous-comparison-of-responses-from-acceleromyography-and-electromyography-based-neuromuscular-monitors
#7
Réka Nemes, Szabolcs Lengyel, György Nagy, David R Hampton, Martyn Gray, J Ross Renew, Edömér Tassonyi, Béla Fülesdi, Sorin J Brull
BACKGROUND: The paucity of easy-to-use, reliable objective neuromuscular monitors is an obstacle to universal adoption of routine neuromuscular monitoring. Electromyography (EMG) has been proposed as the optimal neuromuscular monitoring technology since it addresses several acceleromyography limitations. This clinical study compared simultaneous neuromuscular responses recorded from induction of neuromuscular block until recovery using the acceleromyography-based TOF-Watch SX and EMG-based TetraGraph...
July 30, 2021: Anesthesiology
https://read.qxmd.com/read/34296253/a-crack-in-the-wall-or-how-artificial-intelligence-would-classify-pink-floyd
#8
Misha Perouansky, Jamie W Sleigh
No abstract text is available yet for this article.
July 20, 2021: Anesthesiology
https://read.qxmd.com/read/34270702/acute-postoperative-pain-trajectory-groups-reply
#9
Terrie Vasilopoulos, Patrick J Tighe
No abstract text is available yet for this article.
July 16, 2021: Anesthesiology
https://read.qxmd.com/read/34270688/acute-postoperative-pain-trajectory-groups-comment
#10
Henrik Kehlet, Nicolai Bang Foss
No abstract text is available yet for this article.
July 16, 2021: Anesthesiology
https://read.qxmd.com/read/34270686/excitation-of-putative-glutamatergic-neurons-in-the-rat-parabrachial-nucleus-region-reduces-delta-power-during-dexmedetomidine-but-not-ketamine-anesthesia
#11
Eric D Melonakos, Morgan J Siegmann, Charles Rey, Christopher O'Brien, Ksenia K Nikolaeva, Ken Solt, Christa J Nehs
BACKGROUND: Parabrachial nucleus excitation reduces cortical delta oscillation (0.5 to 4 Hz) power and recovery time associated with anesthetics that enhance γ-aminobutyric acid type A receptor action. The effects of parabrachial nucleus excitation on anesthetics with other molecular targets, such as dexmedetomidine and ketamine, remain unknown. The hypothesis was that parabrachial nucleus excitation would cause arousal during dexmedetomidine and ketamine anesthesia. METHODS: Designer Receptors Exclusively Activated by Designer Drugs were used to excite calcium/calmodulin-dependent protein kinase 2α-positive neurons in the parabrachial nucleus region of adult male rats without anesthesia (nine rats), with dexmedetomidine (low dose: 0...
July 16, 2021: Anesthesiology
https://read.qxmd.com/read/34270675/avatar-models-and-radar-plots-the-future-of-intraoperative-anesthesia-monitoring
#12
Byron Rosero-Britton, Sebastian Amaya
No abstract text is available yet for this article.
July 16, 2021: Anesthesiology
https://read.qxmd.com/read/34265037/perioperative-normal-saline-administration-and-delayed-graft-function-in-patients-undergoing-kidney-transplantation-a-retrospective-cohort-study
#13
Kerstin Kolodzie, Ozlem S Cakmakkaya, Eshandeep S Boparai, Mehdi Tavakol, John R Feiner, Mi-Ok Kim, Thomas B Newman, Claus U Niemann
BACKGROUND: Perioperative normal saline administration remains common practice during kidney transplantation. The authors hypothesized that the proportion of balanced crystalloids versus normal saline administered during the perioperative period would be associated with the likelihood of delayed graft function. METHODS: The authors linked outcome data from a national transplant registry with institutional anesthesia records from 2005 to 2015. The cohort included adult living and deceased donor transplants, and recipients with or without need for dialysis before transplant...
July 15, 2021: Anesthesiology
https://read.qxmd.com/read/34259824/gabaergic-neurons-in-the-dorsal-intermediate-lateral-septum-regulate-sleep-wakefulness-and-anesthesia-in-mice
#14
Di Wang, Qingchen Guo, Yu Zhou, Zheng Xu, Su-Wan Hu, Xiang-Xi Kong, Yu-Mei Yu, Jun-Xia Yang, Hongxing Zhang, Hai-Lei Ding, Jun-Li Cao
BACKGROUND: The γ-aminobutyric acid-mediated (GABAergic) inhibitory system in the brain is critical for regulation of sleep-wake and general anesthesia. The lateral septum contains mainly GABAergic neurons, being cytoarchitectonically divided into the dorsal, intermediate, and ventral parts. This study hypothesized that GABAergic neurons of the lateral septum participate in the control of wakefulness and promote recovery from anesthesia. METHODS: By employing fiber photometry, chemogenetic and optogenetic neuronal manipulations, anterograde tracing, in vivo electrophysiology, and electroencephalogram/electromyography recordings in adult male mice, the authors measured the role of lateral septum GABAergic neurons to the control of sleep-wake transition and anesthesia emergence and the corresponding neuron circuits in arousal and emergence control...
July 13, 2021: Anesthesiology
https://read.qxmd.com/read/34259811/management-of-extracorporeal-membrane-oxygenation-for-postcardiotomy-cardiogenic-shock
#15
Bhoumesh Patel, Jose L Diaz-Gomez, Ravi K Ghanta, Arthur W Bracey, Subhasis Chatterjee
No abstract text is available yet for this article.
July 13, 2021: Anesthesiology
https://read.qxmd.com/read/34259799/liposomal-bupivacaine-to-treat-postoperative-pain-comment
#16
Ashley V Wells, Ryan Lippell, Roniel Y Weinberg, Tiffany R Tedore, Michael Akerman
No abstract text is available yet for this article.
July 13, 2021: Anesthesiology
https://read.qxmd.com/read/34197591/anemia-perioperative-risk-and-treatment-opportunity
#17
Gregory M T Hare, C David Mazer
No abstract text is available yet for this article.
July 1, 2021: Anesthesiology
https://read.qxmd.com/read/34197584/computer-assisted-anesthesia-care-avoiding-the-highway-to-hal
#18
David A Story
No abstract text is available yet for this article.
July 1, 2021: Anesthesiology
https://read.qxmd.com/read/34197582/back-to-the-or-of-the-future-how-do-we-make-it-a-good-one
#19
Martin J London
No abstract text is available yet for this article.
July 1, 2021: Anesthesiology
https://read.qxmd.com/read/34197579/chronic-postoperative-pain-preventable-or-inevitable
#20
J David Clark
No abstract text is available yet for this article.
July 1, 2021: Anesthesiology
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