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Journals Diabetes, Metabolic Syndrome a...

Diabetes, Metabolic Syndrome and Obesity

https://read.qxmd.com/read/38894706/the-regulation-of-metabolic-homeostasis-by-incretins-and-the-metabolic-hormones-produced-by-pancreatic-islets
#1
REVIEW
Joshua Reed, Stephen C Bain, Venkateswarlu Kanamarlapudi
In healthy humans, the complex biochemical interplay between organs maintains metabolic homeostasis and pathological alterations in this process result in impaired metabolic homeostasis, causing metabolic diseases such as diabetes and obesity, which are major global healthcare burdens. The great advancements made during the last century in understanding both metabolic disease phenotypes and the regulation of metabolic homeostasis in healthy individuals have yielded new therapeutic options for diseases like type 2 diabetes (T2D)...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38881697/high-apolipoprotein-b-apolipoprotein-a1-is-associated-with-vitamin-d-deficiency-among-type-2-diabetes-patients
#2
JOURNAL ARTICLE
Shuqi Wang, Haina Gao, Mengmeng Zhang, Shuchun Chen
PURPOSE: To explore the relationship between vitamin D (VitD) deficiency and the apolipoprotein B/apolipoprotein A1 (apo B/A1) in type 2 diabetes mellitus (T2DM) patients. METHODS: This was a retrospective study that lasted 2 years and 6 months, collecting information and laboratory data from 784 patients with T2DM. Patients were divided into VitD deficiency group (n = 433) and non-VitD deficiency group (n = 351) based on VitD levels. Calculated apo B/A1 ratio, and patients were further divided into high-apo B/A1 group (n = 392) and low-apo B/A1 group (n = 392) based on the median of the apo B/A1...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38881696/integrated-bioinformatics-analysis-revealed-immune-checkpoint-genes-relevant-to-type-2-diabetes
#3
JOURNAL ARTICLE
Ziteng Zhang, Guoting Sun, Yuying Wang, Ningjian Wang, Yingli Lu, Yi Chen, Fangzhen Xia
OBJECTIVE: Chronic low-grade inflammation of the pancreatic islets is the characteristic of type 2 diabetes (T2D), and some of the immune checkpoints may play important roles in the pancreatic islet inflammation. Thus, we aim to explore the immune checkpoint genes (ICGs) associated with T2D, thereby revealing the role of ICGs in the pathogenesis of T2D based on bioinformatic analyses. METHODS: Differentially expressed genes (DEGs) and immune checkpoint genes (ICGs) of islets between T2D and control group were screened from datasets of the Gene Expression Omnibus (GEO)...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38881695/effects-of-different-carbohydrate-content-diet-on-gut-microbiota-and-aortic-calcification-in-diabetic-mice
#4
JOURNAL ARTICLE
Xinyi Shen, Ge Guo, Guoquan Feng, Zhongqun Wang
INTRODUCTION: Vascular calcification is a major cause of cardiovascular accidents in patients with type 2 diabetes mellitus. This study aimed to investigate the impact of carbohydrates on gut microbiota and aortic calcification in diabetic ApoE-/- mice. METHODS: The diabetic ApoE-/- mice were randomly divided into 4 groups: ketogenic diet group, low carbohydrate diet group, medium carbohydrate diet group, and high carbohydrate diet group. The mice were fed continuously for 6 months, with blood glucose, blood ketone and body weight monitored monthly...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38881694/predictors-of-diabetes-self-management-behaviour-among-type-2-diabetics-in-saudi-arabia-a-cross-sectional-study
#5
JOURNAL ARTICLE
Waad Alhumaidi Alrasasimah, Abdullah Alsabaani
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) requires effective self-care behaviors and social support to manage the condition and prevent complications. This study aimed to examine the influence of demographic characteristics and perceived social support on diabetes self-management behaviors in individuals with T2DM. METHODS: An analytical cross-sectional design was employed to collect data from 300 T2DM patients using validated questionnaires from April to May 2023...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38881693/predictive-effect-of-alternative-insulin-resistance-indexes-on-adverse-cardiovascular-events-in-patients-with-metabolic-syndrome-with-heart-failure
#6
JOURNAL ARTICLE
Qian Xie, Chang Liu, Fen Liu, Xuehe Zhang, Zhiyang Zhang, Xin An, Yining Yang, Xiaomei Li
PURPOSE: Metabolic Syndrome (MS) greatly increases the risk of heart disease and Heart Failure(HF). Insulin Resistance (IR) is considered to be the key to the pathophysiology of MS. The purpose of this study was to evaluate the predictive effect of different alternative indicators of IR on adverse cardiovascular events in patients with MS complicated with HF. METHODS: Patients with HF who were diagnosed with MS in the heart center of the first affiliated Hospital of Xinjiang Medical University were selected continuously...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38872713/barriers-and-facilitators-of-self-management-in-older-people-with-type-1-diabetes-a-narrative-review-focusing-on-cognitive-impairment
#7
REVIEW
Luciana Mascarenhas Fonseca, Juliana Janeiro Schmidt, Frank J Snoek, Ruth S Weinstock, Naomi Chaytor, Heather Stuckey, Christopher M Ryan, Eelco van Duinkerken
Over the past decades, life expectancy of people with type 1 diabetes has increased considerably, which brings potential challenges due to the process of aging. Cognitive aging and dementia, as well as reductions in visual acuity, hearing and dexterity, can influence the frequency and quality of daily self-management activities, including medication taking and insulin dosing, glucose self-monitoring, and healthy eating. This can increase the risk for hypo- and hyperglycemic events, which, in turn, may contribute to cognitive decline...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38868630/the-relationship-between-insulin-resistance-indicated-by-triglyceride-and-glucose-index-and-left-ventricular-hypertrophy-and-decreased-left-ventricular-diastolic-function-with-preserved-ejection-fraction
#8
JOURNAL ARTICLE
Chengzhang Yang, Weifang Liu, Zijia Tong, Fang Lei, Lijin Lin, Xuewei Huang, Xingyuan Zhang, Tao Sun, Gang Wu, Huajing Shan, Shaoze Chen, Hongliang Li
AIM: The evidence on the association between insulin resistance (IR) and the prevalence or incidence of cardiac dysfunction has been controversial, and the relationship between pre-diabetic IR and cardiac function is lacking. Large sample studies in the Chinese general population are urgently needed to explore the association between IR and the risk of left ventricular hypertrophy (LVH) and decreased left ventricular diastolic function with preserved ejection fraction (LVDFpEF). METHODS: Based on a National Health Check-up database in China, we conducted a multicenter cross-sectional retrospective study in 344,420 individuals...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38863519/association-between-the-hepatic-steatosis-index-and-risk-of-incident-type-2-diabetes-mellitus-in-the-normoglycemic-population-a-longitudinal-prospective-study-in-japan
#9
JOURNAL ARTICLE
Rite Si, Jingyi Xiao, Keyang Zheng, Yuzhe Yin, Yamin Li
PURPOSE: The Hepatic Steatosis Index (HSI) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD), which can increase the risk of type 2 diabetes mellitus (T2DM). However, limited research has directly predicted HSI's association with T2DM occurrence at normal blood glucose levels. Hence, this study aimed to assess the link between baseline HSI and T2DM development under euglycemic conditions while also exploring potential sex differences. METHODS: Using data from the NAGALA cohort study, a Cox regression model analyzed the relationship between HSI and T2DM risk, calculating hazard ratios (HR) and 95% confidence intervals (CI)...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38863518/gestational-diabetes-mellitus-risk-factors-in-pregnant-women-attending-public-health-institutions-in-ethiopia-s-sidama-region-an-unmatched-case-control-study
#10
JOURNAL ARTICLE
Girma Tenkolu Bune
BACKGROUND: Gestational diabetes mellitus (GDM), a chronic condition leading to glucose intolerance during pregnancy, is common in low- and middle-income countries, posing health risks to both the mother and fetus. Limited studies have been done in Ethiopia, especially using WHO's 2013 universal screening criteria. Therefore, this study aimed to evaluate the risk factors linked to GDM in women attending antenatal (ANC) clinics in Hawassa town public health institutions, located in the Sidama regional state of Ethiopia...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38859997/prevalence-of-anemia-in-type-2-diabetic-patients-and-%C3%A2-correlation-with-body-mass-index-and-kidney-%C3%A2-function-in-palestine
#11
JOURNAL ARTICLE
Alaa Elsayed Fathi, Moyad Shahwan, Nageeb Hassan, Ammar Abdulrahman Jairoun, Monzer Shahwan
BACKGROUND: The objective of this study was to determine the prevalence of anemia in patients with type 2 diabetes mellitus and ‎to identify the set of anthropometric and biochemical factors that jointly influence ‎the diabetic and anemic patients including ‎body mass index and kidney function.‎‎. METHODS: A retrospective cross-sectional design study that was carried out in a private medical center ‎in Palestine. The study included a total of 453 patients with type 2 diabetes...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38859996/mri-measured-pancreatic-fat-correlates-with-increased-arterial-stiffness-in-patients-who-are-overweight-and-obese
#12
JOURNAL ARTICLE
Chenxi Li, Xiaolei Chen, Xiaowen Zhu, Mengjiao Cao, Qunfeng Tang, Wenjun Wu
PURPOSE: Arterial stiffness is often increased in overweight or obese individuals before the development of hypertension (HT). This study aimed to determine the connection between pancreatic fat and atherosclerosis in overweight and obese people without HT. PATIENTS AND METHODS: We included 128 patients who were non-hypertensive and overweight or obese in a study between December 2019 and November 2022. Medical history was collected, and all participants underwent a physical examination and blood tests...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38859995/serum-gamma-glutamyltransferase-a-biomarker-for-identifying-postprandial-hypertriglyceridemia
#13
JOURNAL ARTICLE
Kunjie Zheng, Xiaolong Li, Yihua Rong, Xuejing Wang, Liping Hou, Wei Gu, Xiaoyu Hou, Yunpeng Guan, Lifang Liu, Jianlin Geng, Guangyao Song
PURPOSE: Elevated serum gamma-glutamyltranspeptidase (GGT) is an independent marker of the activation of systemic inflammation, while conditions associated with elevated triglyceride (TG) levels, such as type 2 diabetes, non-alcoholic fatty liver disease, obesity, and metabolic syndrome, are associated with an increased inflammatory burden. Moreover, serum liver enzymes (GGT, alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]) are associated with metabolic syndrome and its components, including hypertriglyceridemia...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38854448/plasma-asprosin-concentrations-are-associated-with-progression-of-diabetic-kidney-disease
#14
JOURNAL ARTICLE
Mingyue Xu, Chunlin Zhang, Linlin Zhang, Hua Qu, Yuren Wang
PURPOSE: To explore the expression of asprosin in subjects with pre-DKD and DKD and to analyze its relationship with kidney injury, inflammation, and glucose and lipid metabolism. METHODS: Based on urine albumin:creatinine ratio (UACr), participants were divided into DM, pre-DKD, and DKD groups. Relevant human physiological and biochemical parameters were detected in the three groups. RESULTS: We found relatively higher levels of asprosin in both pre-DKD and DKD groups than the DM group...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38854447/distribution-of-the-ace-gene-polymorphisms-in-type-2-diabetes-mellitus-patients-their-associations-with-nephropathy-biomarkers-and-metabolic-indicators-at-a-tertiary-hospital-in-uganda
#15
JOURNAL ARTICLE
Ritah Kiconco, Robert Kalyesubula, Gertrude N Kiwanuka
PURPOSE: We aimed at determining the distribution of the ACE insertion/deletion gene polymorphisms among type 2 diabetic patients and their association with the nephropathy biomarkers and the metabolic indicators. PATIENTS AND METHODS: Data were collected from 237 adult type 2 diabetes mellitus patients receiving healthcare at the diabetic clinic of Mbarara Regional Referral Hospital. Peripheral blood genomic DNA was amplified using a conventional PCR technique and analyzed for the ACE homozygous forms of the insertion (II), deletion (DD) and heterozygous insertion deletion (ID) genotypes as well as their respective allele counts...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38854446/frequent-self-monitoring-blood-glucose-correlated-to-better-medication-adherence-and-glycemic-control-in-children-with-type-1-diabetes-mellitus
#16
JOURNAL ARTICLE
Nur Rochmah, Soetjipto Soetjipto, Muhammad Faizi, Yuni Hisbiyah, Rayi Kurnia Perwitasari, Katherine Fedora, Laili Nur Rosyidah, Endarko Endarko, Djoko Kuswanto, Eka Agustia Rini
BACKGROUND: Type 1 diabetes mellitus (T1DM) is the most common chronic disease in children, with several severe short and long-term complications. Glycemic control is an important aspect of diabetes management with the most influential factor being compliance with self-monitoring blood glucose (SMBG). Mostly, in Indonesia, the finger stick devices as a glucose monitoring tool were frequently used. About 20% of children follow the recommendation to measure blood glucose four to six times daily...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38854445/effects-of-recombinant-human-granulocyte-macrophage-colony-stimulating-factor-on-diabetic-lower-extremity-ulcers-case-series-of-nine-patients-response-to-letter
#17
COMMENT
Xiaoling Zhang, Jing Tao, Song Gong, Xuefeng Yu, Shiying Shao
No abstract text is available yet for this article.
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38854444/effect-of-sophorox-%C3%A2-on-oxidative-stress-and-body-composition-in-individuals-with-high-bmi-a-randomized-controlled-trial
#18
JOURNAL ARTICLE
James M Roza, Shalini Srivastava
PURPOSE: The study aimed to investigate the efficacy and safety of SophorOx® (LN-OS-22) on oxidative stress and body composition in adults with excessive body weight and obesity. PARTICIPANTS AND METHODS: The 56-days randomized, double-blind, placebo-controlled, parallel-group, multi-centric clinical trial had individuals aged 30-60 years with body mass index (BMI) ≥25 to ≤34.9 kg/m2 . 68 participants were randomly allocated to LN-OS-22 or placebo groups...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38854443/comparison-of-the-effects-of-combined-femoral-and-sciatic-nerves-block-versus-general-anesthesia-on-hemodynamic-stability-and-postoperative-complication-in-patients-with-diabetic-foot-a-prospective-double-blind-and-randomized-controlled-trial
#19
JOURNAL ARTICLE
Liyun Zou, Qiufeng Wei, Sining Pan, Fei Xiao, Yage Jiang, Yu Zhong, Yubo Xie
BACKGROUND: Perioperative anesthetic management of patients with diabetic foot undergoing surgical treatment is challenging due to their poor cardiovascular health status. According to previous literature, general anesthesia and peripheral nerve block have their own advantages and disadvantages for such patients. We reported the effect of these two anesthesia techniques on perioperative hemodynamics and prognosis in these patients. METHODS: This study employed a prospective randomized controlled design, where patients meeting the inclusion criteria were assigned to two groups: the general anesthesia group (GA group) and the peripheral nerve block group (PNB group)...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38835730/high-urine-albumin-to-creatinine-ratio-is-associated-with-increased-arterial-stiffness-in-diabetes-a-chinese-cross-sectional-study-letter
#20
JOURNAL ARTICLE
Ling Feng, Rongyan Wei, Zhenwei Zhai
No abstract text is available yet for this article.
2024: Diabetes, Metabolic Syndrome and Obesity
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