journal
https://read.qxmd.com/read/38831961/beneficial-effects-of-capybara-oil-supplementation-on-steatosis-and-liver-apoptosis-in-obese-mice
#1
JOURNAL ARTICLE
Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho Dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho
Obesity is a complex chronic disease characterized by excess body fat (adipose) that is harmful to health and has been a major global health problem. It may be associated with several diseases, such as nonalcoholic fatty liver disease (NAFLD). Polyunsaturated fatty acids (PUFA) are lipid mediators that have anti-inflammatory characteristics and can be found in animals and plants, with capybara oil (CO) being a promising source. So, we intend to evaluate the hepatic pathophysiological alterations in C57Bl/6 mice with NAFLD, caused by obesity, and the possible beneficial effects of OC in the treatment of this disease...
2024: Journal of Obesity
https://read.qxmd.com/read/38817395/association-between-bmi-change-transaminases-and-other-metabolic-parameters-in-children-with-nonalcoholic-fatty-liver-disease
#2
JOURNAL ARTICLE
Alvaro G Flores Lopez, Ruben E Quiros-Tejeira, Elizabeth Lyden, Brooke McGill, Chinenye R Dike
BACKGROUND: Weight loss and lifestyle interventions are the mainstay of treatment in pediatric NAFLD. There are gaps in the literature on the objective improvement in BMI to meaningfully impact NAFLD in children. AIM: To determine the decrease in BMI associated with a significant decline in ALT and other metabolic parameters. METHODS: Retrospective chart review of pediatric patients with the diagnosis of NAFLD. Data were collected at the baseline and 6 and 12 months...
2024: Journal of Obesity
https://read.qxmd.com/read/38779349/the-burden-of-obesity-in-cardiac-surgery-a-14-years-follow-up-of-14-754-patients
#3
JOURNAL ARTICLE
Alexander Beckmann, Maximilian Poehlmann, Patrick Mayr, Markus Krane, Johannes Boehm
AIMS: The prevalence of obesity is rapidly increasing during the past decades. While previous research has focused on the early outcome after cardiac surgery or specific complications, the current study covers the whole burden of obesity in the field of cardiac surgery over short term and long term. Endpoints of the study were all-cause mortality, perioperative outcome, and wound-healing disorders (WHDs). METHODS: 14.754 consecutive patients who underwent cardiac surgery over a 14 years' time period were analyzed...
2024: Journal of Obesity
https://read.qxmd.com/read/38765635/a-comprehensive-review-on-weight-gain-following-discontinuation-of-glucagon-like-peptide-1-receptor-agonists-for-obesity
#4
REVIEW
Ibrahim Abdullah Bin Ahmed
Obesity is considered the leading public health problem in the medical sector. The phenotype includes overweight conditions that lead to several other comorbidities that drastically decrease health. Glucagon-like receptor agonists (GLP-1RAs) initially designed for treating type 2 diabetes mellitus (T2DM) had demonstrated weight loss benefits in several clinical trials . In vivo studies showed that GLP-1RA encourages reduced food consumption and consequent weight reduction by stimulating brown fat and enhancing energy outlay through the action of the sympathetic nervous system (SNS) pathways...
2024: Journal of Obesity
https://read.qxmd.com/read/38566891/physiopathology-and-treatment-of-obesity-and-overweight-a-proposal-for-a-new-anorectic
#5
REVIEW
Bruno Silvestrini, Mauro Silvestrini
The "new epidemic," as WHO calls obesity, is caused by overeating, which, having exceeded the body's actual needs, accumulates in the form of health-damaging fat deposits. Moving more and eating less is the main remedy, but eating belongs to vital instincts, which are beyond the control of reason. In this sense, eating is different from drinking and breathing because without food it is possible to survive for a few weeks, without water for a few days, without oxygen for a few minutes. The first part of this article provides an overview of obesity and its treatment, focusing on the new anorectic anticipated in the title...
2024: Journal of Obesity
https://read.qxmd.com/read/38550672/the-important-role-of-phosphatidylserine-adam17-tnf-alpha-and-soluble-mer-on-efferocytosis-activity-in-central-obesity
#6
JOURNAL ARTICLE
Chandra Agung Purnama, Anna Meiliana, Melisa Intan Barliana, Keri Lestari, Andi Wijaya
BACKGROUND: Obesity is expected to hinder efferocytosis due to ADAM17-mediated cleavage of the MER tyrosine kinase receptor, producing soluble MER (sMER) that disrupts MERTK binding to cell death markers. However, the intracellular efferocytosis pathway in central obesity remains elusive, particularly the role of low-grade chronic inflammation in its initiation and identification of binding signals that disrupt efferocytosis. OBJECTIVE: We investigate the efferocytosis signaling pathway in men with central obesity and its relationship with inflammation, cell death, and related processes...
2024: Journal of Obesity
https://read.qxmd.com/read/38410415/exploring-the-prevalence-and-components-of-metabolic-syndrome-in-sub-saharan-african-type-2-diabetes-mellitus-patients-a-systematic-review-and-meta-analysis
#7
REVIEW
Nelson Musilanga, Hussein Nasib, Given Jackson, Frank Shayo, Clarkson Nhanga, Saleh Girukwigomba, Ambokile Mwakibolwa, Samson Henry, Keneth Kijusya, Edgar Msonge
BACKGROUND: Type 2 diabetes mellitus and metabolic syndrome represent two closely intertwined public health challenges that have reached alarming epidemic proportions in low- and middle-income countries, particularly in sub-Saharan Africa. Therefore, the current study aimed to determine the weighted pooled prevalence of metabolic syndrome and its components among individuals with type 2 diabetes mellitus in sub-Saharan Africa as defined by the 2004 National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III 2004) and/or the International Diabetes Federation (IDF) criteria...
2024: Journal of Obesity
https://read.qxmd.com/read/38250713/the-concentrations-of-interleukin-6-insulin-and-glucagon-in-the-context-of-obesity-and-type-2-diabetes-and-single-nucleotide-polymorphisms-in-il6-and-ins-genes
#8
JOURNAL ARTICLE
Magdalena Król-Kulikowska, Iwona Urbanowicz, Marta Kepinska
Obesity and diabetes are a problem of modern medicine. Although the environmental factors contributing to the development of these diseases are widely known, research into genetic factors is still ongoing. At the same time, the role of inflammation in the pathophysiology of obesity and diabetes is increasingly emphasized. Therefore, the purpose of this study was to investigate the influence of two selected polymorphisms (rs1800795 and rs3842729) on the development of obesity and type 2 diabetes. In this study, 118 participants were examined, including a control group (nonobese and nondiabetic group), an obese group, and a diabetic group...
2024: Journal of Obesity
https://read.qxmd.com/read/38169925/glucagon-like-peptide-1-glp-1-during-ramadan-narrative-review-of-the-published-literature
#9
REVIEW
Khalid Mohammed Alayed
Ramadan fasting, a religious practice observed by Muslims worldwide, involves abstaining from eating, drinking, smoking, and using oral medications from dawn to dusk during the ninth lunar month. Studies have demonstrated that fasting during Ramadan has been shown to increase HDL cholesterol, leptin, adiponectin, and insulin sensitivity, as well as lower several hemostatic risk factors for cardiovascular diseases. Additionally, it may result in a drop in blood sugar levels, especially in diabetics who are also on blood sugar-lowering medicine...
2023: Journal of Obesity
https://read.qxmd.com/read/38026824/the-interplay-between-adipose-tissue-properties-and-levels-of-nt-probnp-in-people-with-hiv
#10
JOURNAL ARTICLE
Mads-Holger Bang Jacobsen, Anne Marie Reimer Jensen, Andreas Dehlbæk Knudsen, Thomas Benfield, Ruth Frikke-Schmidt, Børge Nordestgaard, Shoaib Afzal, Klaus Fuglsang Kofoed, Marco Gelpi, Susanne Dam Nielsen
OBJECTIVE: We aimed to assess the association between low N-terminal pro-brain natriuretic peptide (NT-proBNP) and body mass index (BMI), adipose tissue distribution, adiponectin, and HIV-specific risk factors among people with HIV (PWH). METHODS: We included 811 PWH with measurement of height, weight and waist circumference, blood samples analyzed for NT-proBNP, and visceral-(VAT) and subcutaneous (SAT) adipose tissue areas measured from CT-scans. Low concentrations of NT-proBNP were defined as concentrations below the limit of quantification (5...
2023: Journal of Obesity
https://read.qxmd.com/read/38026823/defining-and-diagnosing-obesity-in-india-a-call-for-advocacy-and-action
#11
REVIEW
Sanjay Kalra, Nitin Kapoor, Madhur Verma, Shehla Shaikh, Sambit Das, Jubbin Jacob, Rakesh Sahay
The prevalence of overweight and obesity has more than doubled since 1980, and it is predicted that around two-thirds of the global burden of the disease will be attributed to chronic non-communicable diseases. Developing countries are experiencing a more dramatic rise in the prevalence of obesity in recent years. As per National Family Health Survey-5 (NFHS-5), one in every four Indians is now having obesity. It has been reported that being overweight and obese is a significant problem among different socioeconomic spectrums of men and women in India, especially among the elderly, people residing in urban regions, and diverse socioeconomic strata...
2023: Journal of Obesity
https://read.qxmd.com/read/38026822/the-benefits-of-low-carbohydrate-high-fat-lchf-diet-on-body-composition-leg-volume-and-pain-in-women-with-lipedema
#12
JOURNAL ARTICLE
Małgorzata Jeziorek, Angelika Chachaj, Monika Sowicz, Agnieszka Adaszyńska, Aleksander Truszyński, Justyna Putek, Krzysztof Kujawa, Andrzej Szuba
This study aimed to assess the potential benefits of a low-carbohydrate, high-fat (LCHF) diet on body composition, leg volume, and pain reduction in women with lipedema compared to overweight or women with obesity. The study included 113 female participants, 56 with lipedema and 57 with overweight/obesity (BMI >25 kg/m2 ) without lipedema. All subjects were prescribed a low-carbohydrate, high-fat (LCHF) diet with anti-inflammatory properties to adhere to for a duration of 7 months. Measurements of anthropometry, body weight, composition, and pain (VAS) were conducted at the study's commencement and conclusion...
2023: Journal of Obesity
https://read.qxmd.com/read/37908490/white-matter-integrity-abnormalities-in-healthy-overweight-individuals-revealed-by-whole-brain-meta-analysis-of-diffusion-tensor-imaging-studies
#13
REVIEW
Xiaodong Cheng, Wenchang Wang, Chen Sun, Yana Sun, Cong Zhou
OBJECTIVE: This study aimed to conduct a coordinate-based meta-analysis (CBMA) to investigate white matter (WM) abnormalities in healthy individuals with overweight or obesity. METHODS: A systematic literature search using Web of Science and PubMed datasets was performed. Original investigations that used diffusion tensor imaging (DTI) to explore fractional anisotropy (FA) differences between healthy overweight/obese individuals and normal weight controls were collected...
2023: Journal of Obesity
https://read.qxmd.com/read/37901192/the-association-of-adipokines-and-myokines-in-the-blood-of-obese-children-and-adolescents-with-lipoprotein-lipase-rs328-gene-variants
#14
JOURNAL ARTICLE
Alexander V Shestopalov, Vadim V Davydov, Genrik T Tumanyan, Elena D Teplyakova, Tatiana P Shkurat, Elena V Mashkina, Mikhail A Shkurat, Andrey M Gaponov, Anastasia A Sadova, Olga V Borisenko, Sergey A Roumiantsev
Obesity develops largely due to genetic factors, with the genetic polymorphism of lipid metabolism enzymes being of particular importance. However, it is still unclear how the genetic variants of one of the key enzymes in lipid transport, lipoprotein lipase (LPL), are associated with the endocrine function of mesenchymal tissues in obesity. The current study was aimed at the investigation of the LPL rs328 gene variant association with adipokines and myokines levels, as well as lipid metabolism indices in the blood of children and adolescents of both genders with obesity...
2023: Journal of Obesity
https://read.qxmd.com/read/37829557/prevalence-of-gckr-rs1260326-variant-in-subjects-with-obesity-associated-nafld-and-t2dm-a-case-control-study-in-south-punjab-pakistan
#15
JOURNAL ARTICLE
Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed
The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the GCKR rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). This study was conducted to investigate the genetic association of the GCKR rs1260326 in NAFLD and T2DM in our population. NAFLD ( n  = 103), T2DM ( n  = 100), and control ( n  = 100) samples were collected and genotyped for GCKR rs1260326 by tetra-arm PCR...
2023: Journal of Obesity
https://read.qxmd.com/read/37822716/beyond-the-scale-investigating-adiponectin-icam-1-and-vcam-1-as-metabolic-markers-in-obese-adolescents-with-metabolic-syndrome
#16
JOURNAL ARTICLE
Nur Aisiyah Widjaja, Leonardo Alexander Caesar, Suhasta Nova, Eva Ardianah
BACKGROUND: Adiponectin acts to prevent vascular dysfunction due to obesity by inhibiting ICAM-1 and VCAM-1 expressions. OBJECTIVE: We investigate adiponectin ICAM-1, VCAM-1, and metabolic syndrome (MetS) in obese adolescents. METHODS: A cross-sectional study with healthy obese adolescents aged 13 to 18 years was conducted from October 2019 to January 2020. Statistical analysis conducted was a test of normality and homogeneity tests, ANOVA/Kruskal-Wallis, independent sample T -test/Mann-Whitney U test, and Spearman correlation and determined as significant if p value <0...
2023: Journal of Obesity
https://read.qxmd.com/read/37808966/gestational-early-time-restricted-feeding-results-in-sex-specific-glucose-intolerance-in-adult-male-mice
#17
JOURNAL ARTICLE
Molly C Mulcahy, Noura El Habbal, Detrick Snyder, JeAnna R Redd, Haijing Sun, Brigid E Gregg, Dave Bridges
The timing of food intake is a novel dietary component that impacts health. Time-restricted feeding (TRF), a form of intermittent fasting, manipulates food timing. The timing of eating may be an important factor to consider during critical periods, such as pregnancy. Nutrition during pregnancy, too, can have a lasting impact on offspring health. The timing of food intake has not been thoroughly investigated in models of pregnancy, despite evidence that interest in the practice exists. Therefore, using a mouse model, we tested body composition and glycemic health of gestational early TRF (eTRF) in male and female offspring from weaning to adulthood on a chow diet and after a high-fat, high-sucrose (HFHS) diet challenge...
2023: Journal of Obesity
https://read.qxmd.com/read/37794996/impact-of-food-environments-on-obesity-rates-a-state-level-analysis
#18
JOURNAL ARTICLE
Elizabeth Cerceo, Elena Sharma, Anne Boguslavsky, Jean-Sebastien Rachoin
INTRODUCTION: Limited access to healthy food in areas that are predominantly food deserts or food swamps may be associated with obesity. Other unhealthy behaviors may also be associated with obesity and poor food environments. METHODS: We calculated Modified Retail Food Environment Index (mRFEI) to assess food retailers. Using data collected from the Behavioral Risk Factor Surveillance System (BRFSS) survey, the NJ Department of Health (NJDOH), and the US Census Bureau, we conducted a cross-sectional analysis of the interaction of obesity with the food environment and assessed smoking, leisure-time physical activity (LPA), and poor sleep...
2023: Journal of Obesity
https://read.qxmd.com/read/37771449/vitamin-d-concentration-changes-after-bariatric-surgery
#19
JOURNAL ARTICLE
Vanessa Mayana Alves Baad, Narriane Chaves Pereira de Holanda, Juliana Fonseca Nogueira Alves, Francisco Bandeira, Ana Célia Oliveira Dos Santos, Amanda Alves Marcelino da Silva, Taisy Cinthia Ferro Cavalcante
INTRODUCTION: Bariatric surgery causes physiological and anatomical changes in the gastrointestinal tract that interfere with intestinal absorption and, consequently, with the nutritional status, especially about vitamin D. The aim of the study was to evaluate the vitamin D levels and body composition of these patients in the Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) types of surgery. METHODS: The retrospective cohort study included a population of 120 patients aged between 18 and 65 years, with class II or III obesity, undergoing bariatric surgery procedures (VSG or RYGB-type)...
2023: Journal of Obesity
https://read.qxmd.com/read/37766882/delay-discounting-and-the-income-food-insecurity-obesity-paradox-in-mothers
#20
JOURNAL ARTICLE
Leonard H Epstein, Ashfique Rizwan, Rocco A Paluch, Jennifer L Temple
Food insecurity, defined as unpredictable access to food that may not meet a person's nutritional needs, is paradoxically associated with higher BMI (kg/m2 ) and obesity. Research has shown delay discounting, a behavioral economic measure of the preference for immediate rather than delayed rewards, is related to higher BMI, and moderates the relationship between income and food insecurity. Based on this research, we used regression models to test whether delay discounting, consideration of future consequences, and perceived stress were atemporal mediators of the food insecurity-BMI relation in 313 mothers, controlling for demographic variables...
2023: Journal of Obesity
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