journal
https://read.qxmd.com/read/38609099/cannabis-smoking-is-associated-with-advanced-epigenetic-age
#1
LETTER
Ana I Hernandez Cordero, Xuan Li, Chen Xi Yang, Amirtha Ambalavanan, Julia L MacIsaac, Michael S Kobor, Dany Doiron, Wan Tan, Jean Bourbeau, Don D Sin, Qingling Duan, Janice M Leung
No abstract text is available yet for this article.
April 12, 2024: European Respiratory Journal
https://read.qxmd.com/read/38609098/the-paradox-of-the-safer-cigarette-understanding-the-pulmonary-effects-of-electronic-cigarettes
#2
REVIEW
Kassandra Allbright, John Villandre, Laura E Crotty Alexander, Michael Zhang, Kambez H Benam, John Evankovich, Melanie Königshoff, Divay Chandra
Electronic cigarette (e-cigarette) use continues to rise globally. E-cigarettes have been presented as safer alternatives to combustion cigarettes that can mitigate the harm associated with tobacco products; however, the degree to which e-cigarette use itself can lead to morbidity and mortality is not fully defined. Herein we describe how e-cigarettes function; discuss the current knowledge of the effects of e-cigarette aerosol on lung cell cytotoxicity, inflammation, anti-pathogen immune response, mucociliary clearance, oxidative stress, DNA damage, carcinogenesis, matrix remodeling, and airway hyperresponsiveness; and summarize the impact on lung diseases, including COPD, respiratory infection, lung cancer, and asthma...
April 12, 2024: European Respiratory Journal
https://read.qxmd.com/read/38609097/airway-clearance-management-in-people-with-bronchiectasis-data-from-the-european-bronchiectasis-registry-embarc
#3
JOURNAL ARTICLE
Arietta Spinou, Beatriz Hererro-Cortina, Stefano Aliberti, Pieter C Goeminne, Eva Polverino, Katerina Dimakou, Charles S Haworth, Michael R Loebinger, Anthony De Soyza, Montserrat Vendrell, Pierre Regis Burgel, Melissa McDonnell, Sivagurunathan Sutharsan, Sabina Skrgat, Luiz Maiz-Carro, Oriol Sibila, Daiana Stolz, Paula Kauppi, Apostolos Bossios, Adam T Hill, Ian Clifton, Megan L Crichton, Paul Walker, Rosario Menendez, Sermin Borecki, Dusanka Obradovic, Adam Nowinski, Adelina Amorim, Antoni Torres, Natalie Lorent, Tobias Welte, Francesco Blasi, Mateja Jankovic Makek, Michal Shteinberg, Wim Boersma, J Stuart Elborn, James D Chalmers, Felix C Ringshausen
BACKGROUND: International guidelines recommend airway clearance management as one of the important pillars of bronchiectasis treatment. However, the extent to which airway clearance is used for people with bronchiectasis in Europe is unclear. The aim of the study was to identify the use of airway clearance management in patients with bronchiectasis across different countries and factors influencing airway clearance use. METHODS: Prospective observational study using data from the EMBARC Registry between January 2015 and April 2022...
April 12, 2024: European Respiratory Journal
https://read.qxmd.com/read/38609096/the-carbon-footprint-of-as-needed-budesonide-formoterol-in-mild-asthma-a-post-hoc-analysis
#4
JOURNAL ARTICLE
Lee Hatter, Mark Holliday, Allie Eathorne, Pepa Bruce, Ian D Pavord, Helen K Reddel, Robert J Hancox, Alberto Papi, Mark Weatherall, Richard Beasley
INTRODUCTION: The use of pressurised metered-dose inhalers (pMDIs) and asthma exacerbations necessitating healthcare reviews contribute substantially to the global carbon footprint of healthcare. It is possible that a reduction in carbon footprint could be achieved by switching patients with mild asthma from salbutamol pMDI reliever therapy to inhaled corticosteroid-formoterol dry powder inhaler (DPI) reliever therapy, as recommended by the Global Initiative for Asthma (GINA). METHODS: This post hoc analysis included all 668 adult participants in the Novel START trial, who were randomised 1:1:1 to treatment with: as-needed budesonide-formoterol DPI, as-needed salbutamol pMDI, or maintenance budesonide DPI plus as-needed salbutamol pMDI...
April 12, 2024: European Respiratory Journal
https://read.qxmd.com/read/38609095/objective-sputum-colour-assessment-and-clinical-outcomes-in-bronchiectasis-data-from-the-european-bronchiectasis-registry-embarc
#5
JOURNAL ARTICLE
Stefano Aliberti, Felix C Ringshausen, Raja Dhar, Charles S Haworth, Michael R Loebinger, Katerina Dimakou, Megan L Crichton, Anthony De Soyza, Montse Vendrell, Pierre-Regis Burgel, Melissa McDonnell, Sabina Skrgat, Luis Maiz Carro, Andres de Roux, Oriol Sibila, Apostolos Bossios, Menno van der Eerden, Paula Kauppi, Robert Wilson, Branislava Milenkovic, Rosario Menendez, Marlene Murris, Sermin Borekci, Oxana Munteanu, Dusanka Obradovic, Adam Nowinski, Adelina Amorim, Antoni Torres, Natalie Lorent, Eva Van Braeckel, Josje Altenburg, Amelia Shoemark, Michal Shteinberg, Wim Boersma, Pieter C Goeminne, J Stuart Elborn, Adam T Hill, Tobias Welte, Francesco Blasi, Eva Polverino, James D Chalmers
INTRODUCTION: A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In the EMBARC registry, we tested whether sputum colour would be associated with disease severity and clinical outcomes. METHODS: Prospective, observational registry of adults with bronchiectasis conducted in 31 countries. Patients who did not produce spontaneous sputum were excluded from the analysis. The Murray sputum colour chart was used at baseline and at follow-up visits...
April 12, 2024: European Respiratory Journal
https://read.qxmd.com/read/38609094/airway-remodelling-in-asthma-and-the-epithelium-on-the-edge-of-a-new-era
#6
REVIEW
Gilda Varricchi, Christopher E Brightling, Christopher Grainge, Bart N Lambrecht, Pascal Chanez
Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the epithelium can initiate remodelling via an inflammatory cascade involving a variety of mediators that have downstream effects on both structural and immune cells. These mediators include the epithelial cytokines thymic stromal lymphopoietin (TSLP), interleukin 33 and interleukin 25, which facilitate airway remodelling through cross-talk between epithelial cells and fibroblasts, and between mast cells and airway smooth muscle cells, as well as through signalling with immune cells like macrophages...
April 12, 2024: European Respiratory Journal
https://read.qxmd.com/read/38575162/benralizumab-in-severe-eosinophilic-asthma-by-previous-biologic-use-and-key-clinical-subgroups-real-world-xaloc-1-programme
#7
JOURNAL ARTICLE
David J Jackson, Girolamo Pelaia, Benjamin Emmanuel, Trung N Tran, David Cohen, Vivian H Shih, Anat Shavit, Douglas Arbetter, Rohit Katial, Adrian Paul J Rabe, Esther Garcia Gil, Marisa Pardal, Javier Nuevo, Michael Watt, Silvia Boarino, Sheena Kayaniyil, Cláudia Chaves Loureiro, Alicia Padilla-Galo, Parameswaran Nair
BACKGROUND: Pivotal Phase 3 trials and real-world studies have demonstrated benralizumab's overall efficacy and safety in severe eosinophilic asthma (SEA). Additional large-cohort data are needed to confirm its real-world effectiveness in SEA according to previous biologic use and key baseline characteristics important for treatment selection. METHODS: XALOC-1 is a large, multinational, retrospective, observational, real-world study programme of benralizumab in adults with SEA...
April 4, 2024: European Respiratory Journal
https://read.qxmd.com/read/38575161/symptoms-before-and-after-covid-19-a-population-and-case-control-study-using-prospective-data
#8
JOURNAL ARTICLE
Carole H Sudre, Michela Antonelli, Nathan J Cheetham, Erika Molteni, Liane S Canas, Vicky Bowyer, Ben Murray, Khaled Rjoob, Marc Modat, Joan Capdevila Pujol, Christina Hu, Jonathan Wolf, Tim D Spector, Alexander Hammers, Claire J Steves, Sebastien Ourselin, Emma L Duncan
BACKGROUND: Some individuals experience prolonged illness after acute COVID-19. We assessed whether pre-infection symptoms affected post-COVID illness duration. METHODS: Survival analysis was performed in adults (n=23 452) with community-managed SARC-CoV-2 infection prospectively self-logging data through the ZOE COVID Symptom Study app, at least weekly, from 8 weeks before to 12 weeks after COVID-19 onset, conditioned on presence versus absence of baseline symptoms (4-8 weeks before COVID-19)...
April 4, 2024: European Respiratory Journal
https://read.qxmd.com/read/38575160/adverse-pregnancy-outcomes-and-pharyngeal-flow-limitation-during-sleep-nulliparous-pregnancy-outcomes-study-monitoring-mothers-to-be-numom2b
#9
JOURNAL ARTICLE
Raichel M Alex, Dwayne L Mann, Ali Azarbarzin, Daniel Vena, Laura K Gell, Andrew Wellman, William A Grobman, Francesca L Facco, Robert M Silver, Grace W Pien, Judette M Louis, Phyllis C Zee, Michael Rueschman, Tamar Sofer, Susan Redline, Scott A Sands
RATIONALE: Pharyngeal flow limitation during pregnancy may be a risk factor for adverse pregnancy outcomes but was previously challenging to quantify. OBJECTIVE: To determine whether a novel objective measure of flow limitation identifies an increased risk of preeclampsia (primary outcome) and other adverse outcomes in a prospective cohort: Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be. METHODS: Flow limitation severity scores (0%=fully obstructed, 100%=open airway)- quantified from breath-by-breath airflow shape-were obtained from home sleep tests during early (6-15 weeks) and mid (22-31 weeks) pregnancy...
April 4, 2024: European Respiratory Journal
https://read.qxmd.com/read/38575159/tricuspid-regurgitation-in-pulmonary-arterial-hypertension-a-right-ventricular-volumetric-and-functional-analysis
#10
JOURNAL ARTICLE
Keimei Yoshida, Jessie van Wezenbeek, Jeroen N Wessels, Frances S de Man, Kenji Sunagawa, Anton Vonk-Noordegraaf, Harm Jan Bogaard
BACKGROUND AND AIMS: The consequences of tricuspid regurgitation (TR) for right ventricular (RV) function and prognosis in pulmonary arterial hypertension (PAH) are poorly described and effects of tricuspid valve repair on the RV are difficult to predict. METHODS: In 92 PAH patients with available cardiac magnetic resonance (CMR) studies, TR volume was calculated as the difference between RV stroke volume and forward stroke volume, i.e. pulmonary artery stroke volume...
April 4, 2024: European Respiratory Journal
https://read.qxmd.com/read/38575158/high-risk-of-lung-cancer-in-surfactant-related-gene-variant-carriers
#11
JOURNAL ARTICLE
Alexandre Brudon, Marie Legendre, Arthur Mageau, Julien Bermudez, Philippe Bonniaud, Diane Bouvry, Jacques Cadranel, Aurélie Cazes, Bruno Crestani, Tristan Dégot, Céline Delestrain, Rémi Diesler, Ralph Epaud, Quentin Philippot, Nathalie Theou-Anton, Caroline Kannengiesser, Ibrahima Ba, Marie-Pierre Debray, Pascale Fanen, Efrosine Manali, Spyros Papiris, Nadia Nathan, Serge Amselem, Antoine Gondouin, Anne Guillaumot, Claire Andréjak, Stephane Jouneau, Guillaume Beltramo, Yurdagul Uzunhan, François Galodé, Virginie Westeel, Anas Mehdaoui, Sandrine Hirschi, Sylvie Leroy, Sylvain Marchand-Adam, Hilario Nunes, Clément Picard, Grégoire Prevot, Martine Reynaud-Gaubert, Paul De Vuyst, Lidwine Wemeau, Gautier Defossez, Gérard Zalcman, Vincent Cottin, Raphael Borie
RATIONALE: Several rare surfactant-related genes variants associated with interstitial lung disease are suspected to be associated with lung cancer, but data are missing. OBJECTIVES: We aimed to study the epidemiology and phenotype of lung cancer in an international cohort of surfactant-related gene (SRG) variant carriers. METHODS: We conducted a cross-sectional study of all adults with SRG variants in the OrphaLung network and compared lung cancer risk with telomerase-related gene (TRG) variant carriers...
April 4, 2024: European Respiratory Journal
https://read.qxmd.com/read/38575157/viewing-pulmonary-hypertension-through-a-pediatric-lens
#12
JOURNAL ARTICLE
Stuti Agarwal, Jeffrey Fineman, David N Cornfield, Cristina M Alvira, Roham T Zamanian, Kara Goss, Ke Yuan, Sebastien Bonnet, Olivier Boucherat, Soni Pullamsetti, Miguel A Alcázar, Elena Goncharova, Tatiana V Kudryashova, Mark R Nicolls, Vinicio de Jesús Pérez
No abstract text is available yet for this article.
April 4, 2024: European Respiratory Journal
https://read.qxmd.com/read/38548292/state-of-the-art-review-advances-in-copd-imaging-using-ct-and-mri-linkage-with-lung-physiology-and-clinical-outcomes
#13
JOURNAL ARTICLE
Amany F Elbehairy, Helen Marshall, Josephine H Naish, Jim M Wild, Grace Parraga, Alexander Horsley, Jørgen Vestbo
Recent years have witnessed major advances in lung imaging in patients with chronic obstructive pulmonary disease (COPD). These include significant refinements in images obtained by computed tomography (CT) scans together with the introduction of new techniques and software that aim for obtaining the best image while using the lowest possible radiation dose. Magnetic resonance imaging (MRI) has also emerged as a useful radiation-free tool in assessing structural and more importantly functional derangements in patients with well-established COPD and smokers without COPD, even before the existence of overt changes in resting physiological lung function tests...
March 28, 2024: European Respiratory Journal
https://read.qxmd.com/read/38548291/polysomnographic-airflow-shapes-and-site-of-collapse-during-drug-induced-sleep-endoscopy
#14
JOURNAL ARTICLE
Sara Op de Beeck, Daniel Vena, Dwayne Mann, Ali Azarbarzin, Phillip Huyett, Eli Van de Perck, Laura K Gell, Raichel M Alex, Marijke Dieltjens, Marc Willemen, Johan Verbraecken, Andrew Wellman, Olivier M Vanderveken, Scott A Sands
RATIONALE: Differences in the pharyngeal site-of-collapse influences efficacy of non-CPAP therapies for obstructive sleep apnoea (OSA). Notably, complete concentric collapse at the palate (CCCp) during drug-induced sleep endoscopy (DISE) is associated with reduced efficacy of hypoglossal nerve stimulation, but CCCp is currently not recognisable using polysomnography. Here we develop a means to estimate DISE-based site-of-collapse using overnight polysomnography. METHODS: 182 OSA patients provided DISE and polysomnography data...
March 28, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514096/impact-of-obesity-progression-or-regression-on-the-longitudinal-assessment-of-fibrosing-ild
#15
LETTER
Hadeel Alqurashi, Mathieu Marillier, Igor Neder-Serafini, Anne-Catherine Bernard, Onofre Moran-Mendoza, J Alberto Neder
No abstract text is available yet for this article.
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#16
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514094/pulmonary-vascular-phenotype-identified-in-patients-with-gdf2-bmp9-or-bmp10-variants-an-international-multicentre-study
#17
JOURNAL ARTICLE
Julien Grynblat, Harm-Jan Bogaard, Mélanie Eyries, Olivier Meyrignac, Laurent Savale, Xavier Jais, Maria-Rosa Ghigna, Lucas Celant, Lilian Meijboom, Arjan Houweling, Marilyne Levy, Fabrice Antigny, Ari Chaouat, Vincent Cottin, Christophe Guignabert, Florence Coulet, Olivier Sitbon, Damien Bonnet, Marc Humbert, David Montani
BACKGROUND: Bone morphogenetic proteins 9 and 10 (BMP9 and BMP10), encoded by GDF2 and BMP10 , play a pivotal role in pulmonary vascular regulation. GDF2 variants have been reported in pulmonary arterial hypertension (PAH) and hereditary haemorrhagic telangiectasia (HHT). However, the phenotype of GDF2 and BMP10 carriers remains largely unexplored. METHODS: We report the characteristics and outcomes of PAH patients in GDF2 and BMP10 carriers from the French and Dutch PH registry...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514093/gasdermin-b-an-asthma-susceptibility-gene-promotes-mavs-tbk1-signaling-and-airway-inflammation
#18
JOURNAL ARTICLE
Tao Liu, Siqi Liu, Xianliang Rui, Ye Cao, Julian Hecker, Feng Guo, Yihan Zhang, Lu Gong, Yihan Zhou, Yuzhen Yu, Nandini Krishnamoorthyni, Samuel Bates, Sung Chun, Nathan Boyer, Shuang Xu, Jin-Ah Park, Mark A Perrella, Bruce D Levy, Scott T Weiss, Hongmei Mou, Benjamin A Raby, Xiaobo Zhou
RATIONALE: Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of IFN-stimulated genes (ISGs). How asthma genetic susceptible genes modulate cellular response upon viral infection through fine-tuning ISGs induction and subsequent airway inflammation in genetically susceptible asthmatics remains largely unknown. OBJECTIVES: To decipher the functions of GSDMB in respiratory virus-induced lung inflammation...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485151/the-longitudinal-microbial-and-metabolic-landscape-of-infant-cystic-fibrosis-the-gut-lung-axis
#19
JOURNAL ARTICLE
Katherine B Frayman, Matthew Macowan, Jose Caparros-Martin, Sarath C Ranganathan, Benjamin J Marsland
BACKGROUND AND AIM: : In cystic fibrosis (CF), gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2-years of life, its association with growth and airway inflammation, and explanatory features in the metabolome. MATERIALS AND METHODS: Sixty-seven bronchoalveolar lavage (BAL), 62 plasma and 105 stool samples were collected from 39 infants with CF between 0-24-months who were treated with prophylactic antibiotics...
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485150/b-cells-in-pulmonary-arterial-hypertension-friend-foe-or-bystander
#20
REVIEW
Sébastien Sanges, Wen Tian, Sylvain Dubucquoi, Jason L Chang, Aurore Collet, David Launay, Mark R Nicolls
There is an unmet need for new therapeutic strategies that target alternative pathways to improve the prognosis of patients with pulmonary arterial hypertension (PAH). As immunity has been involved in the development and progression of vascular lesions in PAH, we review the potential contribution of B cells in its pathogenesis and evaluate the relevance of B cell-targeted therapies. Circulating B cell homeostasis is altered in PAH patients, with total B-cell lymphopenia, abnormal subset distribution (expansion of naïve and antibody-secreting cells, reduction of memory B cells) and chronic activation...
March 14, 2024: European Respiratory Journal
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