Nicholas A Scott, Laurence Pearmain, Sean B Knight, Oliver Brand, David J Morgan, Christopher Jagger, Sarah Harbach, Saba Khan, Halima A Shuwa, Miriam Franklin, Verena Kästele, Thomas Williams, Ian Prise, Flora A McClure, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E Konkel, Criag Lawless, James Wilson, Aleaxander G Mathioudakis, Stefan C Stanel, Andrew Ustianowski, Gabriella Lindergard, Seema Brij, Nawar Diar Bakerly, Paul Dark, Christopher Brightling, Pilar Rivera-Ortega, Graham M Lord, Alex Horsley, Karen Piper Hanley, Timothy Felton, Angela Simpson, John R Grainger, Tracy Hussell, Elizabeth R Mann
BACKGROUND: COVID-19 is associated with a dysregulated immune response but it is unclear how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 patients during convalescence (long COVID). METHODS: We assessed phenotypical and functional changes of monocytes in COVID-19 patients during hospitalization and up to 9 months of convalescence following COVID-19, respiratory syncytial virus (RSV) or influenza A (flu). Progressive fibrosing interstitial lung disease (PFILD) patients were included a positive control for severe, ongoing lung injury...
March 15, 2023: European Respiratory Journal