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Clinical Trial
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Memory enhancement in Korsakoff's psychosis by clonidine: further evidence for a noradrenergic deficit.
Annals of Neurology 1980 May
Three drugs, d-amphetamine, clonidine, and methysertide, which presumably enhance central noradrenergic activity by different pharmacological mechanisms, were administered to eight patients with the Korsakoff syndrome in a two-week subacute, double-blind, counterbalanced experiment to study the effects of these agents on memory function as measured by a neuropsychological test battery. Of the drugs tested, only clonidine, a putative alpha-noradrenergic agonist, was associated with significant improvement in memory. The data are consistent with the hypothesis that damage to ascending norepinephrine-containing neurons in the brainstem and diencephalon may be the basis for amnesia in Korsakoff's psychosis.
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