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Journals American Journal of Respirator...

American Journal of Respiratory and Critical Care Medicine

https://read.qxmd.com/read/32970963/deep-sulcus-sign-look-twice
#1
Michaël Mekeirele, Valérie Broeckhoven, Alexander Wilmer, Tim Balthazar
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32970962/endotypic-mechanisms-of-successful-hypoglossal-nerve-stimulation-for-obstructive-sleep-apnea
#2
Sara Op de Beeck, Andrew Wellman, Marijke Dieltjens, Kingman P Strohl, Marc Willemen, Paul H Van de Heyning, Johan A Verbraecken, Olivier M Vanderveken, Scott A Sands
RATIONALE: Approximately a third of patients with obstructive sleep apnea (OSA) treated with hypoglossal nerve stimulation (HGNS) therapy are incomplete responders, despite careful patient selection based on baseline characteristics and drug-induced sleep endoscopy. Here we use polysomnographic endotyping to assess the pathophysiological mechanisms underlying favorable versus incomplete responses to HGNS therapy. METHODS: Baseline polysomnography data of the STAR trial were included...
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32970458/don-t-forget-about-facilitatory-effects-of-corticosteroids-on-beta-2-adrenoceptors-in-acute-asthma
#3
Brian Lipworth, Rory Chan, Chris RuiWen Kuo
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32970450/reply-to-don-t-forget-about-facilitatory-effects-of-corticosteroids-on-beta-2-adrenoceptors-in-acute-asthma
#4
Angela M Moran, Sanjay Ramakrishnan, Catherine A Borg, Clare M Connolly, Simon Couillard, Christine M Mwasuku, Ian D Pavord, Timothy S C Hinks, Lauri Lehtimäki
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32969708/safety-and-efficacy-of-elexacaftor-tezacaftor-ivacaftor-for-%C3%A2-24-weeks-in-people-with-cf-and-%C3%A2-1-f508del-allele-interim-results-of-an-open-label-phase-three-clinical-trial
#5
Matthias Griese, Stefano Costa, Rachel W Linnemann, Marcus A Mall, Edward F McKone, Deepika Polineni, Bradley S Quon, Felix C Ringshausen, Jennifer L Taylor-Cousar, Nicholas J Withers, Samuel M Moskowitz, Cori L Daines
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32966755/aprepitant-for-cough-in-lung-cancer-a-randomised-placebo-controlled-trial-and-mechanistic-insights
#6
Jaclyn A Smith, Amélie Harle, Rachel Dockry, Kimberley Holt, Philip Russell, Alex Molassiotis, Janelle Yorke, Ryan Robinson, Mark A Birrell, Maria G Belvisi, Fiona Blackhall
RATIONALE: Effective cough treatments are a significant unmet need in lung cancer patients. Aprepitant is a licensed treatment for nausea and vomiting, which blocks substance P activation of Neurokinin 1 (NK-1) receptors, a mechanism also implicated in cough. OBJECTIVE: To assess aprepitant in lung cancer patients with cough and evaluate mechanisms in vagal nerve tissue. METHODS: Randomised double-blind crossover trial of lung cancer patients with bothersome cough...
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32966751/pharmacotherapy-and-lung-function-decline-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review
#7
Bartolome R Celli, Julie A Anderson, Nicholas J Cowans, Courtney Crim, Benjamin F Hartley, Fernando J Martinez, Andrea N Morris, Holly Quasny, Julie Yates, Jørgen Vestbo, Peter M A Calverley
BACKGROUND: Whether pharmacological therapy alters decline in forced expiratory volume in 1 second (FEV1) in chronic obstructive pulmonary disease (COPD) remains controversial. Because pharmacotherapy improves health status, exacerbation rate and symptoms, it is unethical to complete placebo-controlled long-term studies aimed at modifying FEV1 decline. OBJECTIVE: We conducted a systematic review of placebo-controlled pharmacological trials lasting ≥1 year to address the question of whether therapy alters FEV1 decline...
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32966750/cardiopulmonary-resuscitation-associated-lung-edema-the-price-to-pay-to-get-the-heart-beat
#8
Guillaume Geri, Jean-Christophe Richard
No abstract text is available yet for this article.
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32966749/mapping-the-17q12-21-1-locus-for-variants-associated-with-early-onset-asthma-in-african-americans
#9
Hongsheng Gui, Albert M Levin, Donglei Hu, Patrick Sleiman, Shujie Xiao, Angel Cy Mak, Mao Yang, Andrea J Barczak, Scott Huntsman, Celeste Eng, Samantha Hochstadt, Ellen Zhang, Kyle Whitehouse, Samantha Simons, Whitney Cabral, Sami Takriti, Gonçalo Abecasis, Thomas W Blackwell, Hyun Min Kang, Deborah A Nickerson, Soren Germer, David E Lanfear, Frank Gilliland, W James Gauderman, Rajesh Kumar, David J Erle, Fernando D Martinez, Hakon Hakonarson, Esteban G Burchard, L Keoki Williams
RATIONALE: The 17q12-21.1 locus is one of the most highly replicated genetic associations with asthma. Individuals of African descent have lower LD in this region, which could facilitate identifying causal variants. OBJECTIVE: To identify functional variants at 17q12-21.1 associated with early-onset asthma among African American individuals. METHODS AND MEASUREMENTS: We evaluated African American participants from the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) (n=1,940), the Study of African Americans, Asthma, Genes & Environment (SAGE II) (n=885), and Study of the Genetic Causes of Complex Pediatric Disorders - Asthma (GCPD-A) (n=2,805)...
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32966129/supporting-a-precious-resource-healthcare-clinicians
#10
Jin Jun, Deena Kelly Costa
No abstract text is available yet for this article.
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32961066/tissue-doppler-imaging-of-the-diaphragm-a-novel-approach-but-too-early-for-clinical-implementation
#11
Annemijn H Jonkman, Myrte Wennen, Michael C Sklar, Chris de Korte, Pieter R Tuinman
No abstract text is available yet for this article.
September 22, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32961063/reply-to-tissue-doppler-imaging-of-the-diaphragm-a-novel-approach-but-too-early-for-clinical-implementation
#12
Eleni Soilemezi, Savvoula Savvidou, Dimitrios Matamis
No abstract text is available yet for this article.
September 22, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32955926/role-of-il-6-in-severe-inflammation
#13
Ken-Ichiro Inoue, Tomoya Sagawa, Hirohisa Takano
No abstract text is available yet for this article.
September 21, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32955924/reply-to-blot-et-al-and-inoue-et-al
#14
Oliver J McElvaney, Natalie L McEvoy, Noel G McElvaney, Gerard F Curley
No abstract text is available yet for this article.
September 21, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32955921/is-interleukin-6-the-right-target-in-covid-19-severe-pneumonia
#15
Mathieu Blot, Abderrahmane Bourredjem, Christine Binquet, Lionel Piroth
No abstract text is available yet for this article.
September 21, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32946283/time-to-revisit-the-hospital-readmissions-reduction-program-for-patients-hospitalized-for-copd-exacerbations
#16
Stephanie LaBedz, Jerry A Krishnan
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32946275/sleep-apnea-and-covid-19-mortality-and-hospitalization
#17
Brian E Cade, Hassan S Dashti, Syed M Hassan, Susan Redline, Elizabeth W Karlson
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32945694/reply-to-spinelli-e-et-al-and-jha
#18
Roberto Tonelli, Ivana Castaniere, Riccardo Fantini, Luca Tabbì, Stefano Busani, Lara Pisani, Stefano Nava, Enrico Clini, Alessandro Marchioni
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32945690/continued-vigorous-inspiratory-effort-as-a-predictor-of-non-invasive-ventilation-failure
#19
Ajay Kumar Jha
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32945689/control-of-respiratory-drive-by-non-invasive-ventilation-as-an-early-predictor-of-success
#20
Elena Spinelli, Ines Marongiu, Tommaso Mauri
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
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