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Hui Qing, Xiangdong Wang, Nan Zhang, Kaili Zheng, Kun Du, Ming Zheng, Ying Li, Yu Chang, Luo Zhang, Claus Bachert
RATIONALE: Particulate matter with an aerodynamic diameter equal or less than 2.5 µm (PM2.5) represents a main constituent of polluted air with a potential detrimental impact on human health. OBJECTIVES: To investigate the effect of PM2.5 on human nasal mucosa under healthy and pre-existing inflammatory condition. METHODS: Healthy subjects and 6 patients with type-2 inflammations (CRSwNP/AR) were recruited for in vivo sampling of nasal secretions before and after days with high PM2...
July 16, 2019: American Journal of Respiratory and Critical Care Medicine
#2
Samuel T Kuna
No abstract text is available yet for this article.
July 16, 2019: American Journal of Respiratory and Critical Care Medicine
#3
A John Simpson, Anthony J Rostron
No abstract text is available yet for this article.
July 16, 2019: American Journal of Respiratory and Critical Care Medicine
#4
Rene S Bermea, Joseph Miller, W Wyatt Wilson, Karen Dugan, Laura Frye, Septimiu Murgu, D Kyle Hogarth
No abstract text is available yet for this article.
July 16, 2019: American Journal of Respiratory and Critical Care Medicine
#5
Anna-Maria Hoffmann-Vold, Håvard Fretheim, Anne-Kristine Halse, Marit Seip, Helle Bitter, Marianne Wallenius, Torhild Garen, Anne Salberg, Cathrine Brunborg, Øyvind Midtvedt, May Brit Lund, Trond M Aaløkken, Øyvind Molberg
RATIONALE: Interstitial lung disease (ILD) represents a major challenge in systemic sclerosis (SSc), but there are no precise, population-based data on its overall impact, limiting opportunities for screening and management strategies. OBJECTIVE: Evaluate impact of ILD in a unique, nationwide, population based SSc cohort. METHODS: ILD was assessed prospectively in the Norwegian SSc cohort (Nor-SSc) including all 815 SSc patients resident in the country in 2000-2012...
July 16, 2019: American Journal of Respiratory and Critical Care Medicine
#6
Joselyn Rojas-Quintero, Xiaoyun Wang, Caroline A Owen
No abstract text is available yet for this article.
July 12, 2019: American Journal of Respiratory and Critical Care Medicine
#7
Meindina G Haarman, Johannes M Douwes, Mark-Jan Ploegstra, Marcus T R Roofthooft, Theresia Vissia-Kazemier, Hans L Hillege, Rolf M F Berger
No abstract text is available yet for this article.
July 12, 2019: American Journal of Respiratory and Critical Care Medicine
#8
Rahul Shrimanker, Oliver Keene, Gareth Hynes, Sally Wenzel, Steven Yancey, Ian D Pavord
No abstract text is available yet for this article.
July 12, 2019: American Journal of Respiratory and Critical Care Medicine
#9
Sanjay H Chotirmall
No abstract text is available yet for this article.
July 12, 2019: American Journal of Respiratory and Critical Care Medicine
#10
Sharon Elliot, Simone Periera-Simon, Xiaomei Xia, Paola Catanuto, Gustavo Rubio, Shahriar Shahzeidi, Fadi El Salem, Josh Shapiro, Karoline Briegel, Kenneth S Korach, Marilyn K Glassberg
RATIONALE: The relevance of hormones in idiopathic pulmonary fibrosis (IPF), a predominately male lung disease, is unknown. OBJECTIVES: To determine whether the estrogen receptor (ER) facilitates the development of pulmonary fibrosis and is mediated in part through microRNA regulation of ERα and ERα-activated pro-fibrotic pathways. METHODS: ER expression in male lung tissue and myofibroblasts from controls (n=6) and patients with IPF (n=6), aging bleomycin (BLM)-treated mice (n=7), and BLM-treated AF2ERKI mice (n=7) was determined...
July 10, 2019: American Journal of Respiratory and Critical Care Medicine
#11
David B Frank, Edward E Morrisey
No abstract text is available yet for this article.
July 10, 2019: American Journal of Respiratory and Critical Care Medicine
#12
Raquel Guimarães-Costa, Marie-Cécile Niérat, Isabelle Rivals, Capucine Morélot-Panzini, Norma Beatriz Romero, Fabrice Menegaux, François Salachas, Jésus Gonzalez-Bermejo, Thomas Similowski, Gaëlle Bruneteau
No abstract text is available yet for this article.
July 10, 2019: American Journal of Respiratory and Critical Care Medicine
#13
Brett Ley, Dara G Torgerson, Justin M Oldham, Ayodeji Adegunsoye, Shuo Liu, Jie Li, Brett M Elicker, Travis S Henry, Jeffrey A Golden, Kirk D Jones, Amy Dressen, Brian L Yaspan, Joseph R Arron, Imre Noth, Thomas J Hoffmann, Paul J Wolters
RATIONALE: Rare genetic variants in telomere-related genes have been identified in familial, idiopathic, and rheumatoid arthritis-associated pulmonary fibrosis. Short peripheral blood leukocyte (PBL) telomere length predicts poor outcomes in chronic hypersensitivity pneumonitis (CHP). OBJECTIVES: Determine the prevalence and clinical relevance of rare protein-altering variants in telomere-related genes in patients with CHP. METHODS: Next generation sequences from two CHP cohorts were analyzed to identify variants in TERT, TERC, DKC1, RTEL1, PARN, and TINF2...
July 3, 2019: American Journal of Respiratory and Critical Care Medicine
#14
Kengo Koike, Evgeny V Berdyshev, Andrew M Mikosz, Irina A Bronova, Anna S Bronoff, John P Jung, Erica L Beatman, Kevin Ni, Danting Cao, April K Scruggs, Karina A Serban, Irina Petrache
RATIONALE: The loss of pulmonary endothelial cells in emphysema is associated with increased lung ceramide. Ceramide perturbations may cause adaptive alterations in other bioactive sphingolipids, with pathogenic implications. We reported a negative correlation between emphysema and circulating glycosphingolipids (GSLs). Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by glucosylceramide synthase (GCS), is required for embryonic survival, but its role in the lung is unknown...
July 2, 2019: American Journal of Respiratory and Critical Care Medicine
#15
Simon Finch, Amelia Shoemark, Alison J Dicker, Holly R Keir, Alexandria Smith, Samantha Ong, Brandon Tan, Jean-Yu Choi, Thomas C Fardon, Diane Cassidy, Jeffrey T J Huang, James D Chalmers
BACKGROUND: Pregnancy zone protein (PZP) is a broad-spectrum immunosuppressive protein believed to suppress T-cell function during pregnancy to prevent fetal rejection. It has not previously been reported in the airway. OBJECTIVES: To characterise PZP in the bronchiectasis airway including its relationship with disease severity. METHODS: Label free liquid chromatography/mass spectrometry was performed for sputum protein profiling between HRCT confirmed bronchiectasis patients with and without P...
July 2, 2019: American Journal of Respiratory and Critical Care Medicine
#16
Josef Prazak, Manuela Iten, David R Cameron, Jonathan Save, Denis Grandgirard, Gregory Resch, Christine Goepfert, Stephen L Leib, Jukka Takala, Stephan M Jakob, Yok-Ai Que, Matthias Haenggi
RATIONALE: Infections caused by multidrug resistant bacteria are a major clinical challenge. Phage therapy is a promising alternative antibacterial strategy. OBJECTIVE: To evaluate the efficacy of intravenous phage therapy for the treatment of ventilator associated pneumonia due to methicillin-resistant Staphylococcus aureus in rats. METHODS: A randomized blinded controlled experimental study compared intravenous teicoplanin (3mg/kg, n=12), a cocktail of four phages (2-3 x 10^9 plaque forming units/ml of 2003, 2002, 3A and K, n=12) and combination of both (n=11), given two, 12 and 24 hours after induction of pneumonia, then once daily for four days...
July 1, 2019: American Journal of Respiratory and Critical Care Medicine
#17
Felipe de Souza Rossi, Eduardo L V Costa, Daniela Iope, Pedro H D Pacce, Camila Cestaro, Luisa Braz, Albert Bousso, Marcelo B P Amato
No abstract text is available yet for this article.
July 1, 2019: American Journal of Respiratory and Critical Care Medicine
#18
Moran Lavie, Israel Amirav
No abstract text is available yet for this article.
June 28, 2019: American Journal of Respiratory and Critical Care Medicine
#19
Patrick M Meyer Sauteur, Michelle Seiler, Johannes Trück, Wendy W J Unger, Paolo Paioni, Christa Relly, Georg Staubli, Thorsten Haas, Claudine Gysin, Lucas M Bachmann, Annemarie M C van Rossum, Christoph Berger
No abstract text is available yet for this article.
June 28, 2019: American Journal of Respiratory and Critical Care Medicine
#20
Ala-Eddin S Sagar, Saadia A Faiz, Vickie R Shannon
No abstract text is available yet for this article.
June 28, 2019: American Journal of Respiratory and Critical Care Medicine
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