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Sign UpAmerican Journal of Respiratory and Critical Care Medicine
• journal#1
Stefano Guerra, Enrico Lombardi, Debra A Stern, Duane L Sherrill, Dorothy Gilbertson-Dahdal, Courtney M Wheatley-Guy, Eric M Snyder, Anne L Wright, Fernando D Martinez, Wayne J Morgan
RATIONALE: Deficits in infant lung function - including the fraction of expiratory time to peak tidal expiratory flow to total expiratory time (tPTEF/tE) and maximal expiratory flow at functional residual capacity (V̇maxFRC) - have been linked to increased risk for childhood asthma. OBJECTIVES: To examine the individual and combined effects of tPTEF/tE and V̇maxFRC in infancy on risk for asthma and abnormalities of airway structure into mid-adult life. METHODS: 180 participants in the TCRS birth cohort had lung function measured by the chest-compression technique in infancy (mean age±SD: 2...
July 10, 2020: American Journal of Respiratory and Critical Care Medicine
#2
Eugene H Chang, Amanda L Willis, Casey E Romanoski, Darren A Cusanovich, Nima Pouladi, Jianrong Li, Yves A Lussier, Fernando D Martinez
No abstract text is available yet for this article.
July 10, 2020: American Journal of Respiratory and Critical Care Medicine
#3
Gareth Mitchell Forster, Shailesh Bihari, Ravindranath Tiruvoipati, Michael Bailey, David Pilcher
RATIONALE: ICU discharge delay occurs when a patient is considered ready to be discharged but remains in the ICU. The effect of discharge delay on patient outcomes is uncertain. OBJECTIVES: To investigate the association between discharge delay and patient outcomes including hospital mortality, readmission to ICU and length of hospital stay after ICU discharge. METHODS: Data were accessed from the Australian and New Zealand Intensive Care Society Adult Patient Database between 2011-2019...
July 10, 2020: American Journal of Respiratory and Critical Care Medicine
#4
Andrea Zapater, Manuel Sánchez-de-la-Torre, Ivan David Benítez, Adriano Targa, Sandra Bertran, Gerard Torres, Albina Aldomà, Jordi De Batlle, Jorge Abad, Joaquín Duran-Cantolla, Valentin Cabriada-Nuño, Olga Mediano, María José Masdeu, Carmen Muñoz, Juan Fernando Masa, Mónica De la Peña, Mercè Mayos, Ramon Coloma, Josep María Montserrat, Eusebi Chiner, Olga Mínguez, Lydia Pascual, Anunciación Cortijo, Dolores Martínez, Mireia Dalmases, R Doug McEvoy, Ferran Barbé, Alicia Sánchez-de-la-Torre
Rationale Obstructive sleep apnea (OSA) is associated with increased cardiovascular disease (CVD) risk. Conversely, OSA has not been shown to increase recurrent cardiovascular events in acute coronary syndrome (ACS) patients. This lack of homogeneity could suggest that the deleterious effect of OSA and its contribution to CVD could depend on specific patient profiles. Objectives To evaluate the effect of OSA on cardiovascular risk for patients with different ACS phenotypes. Methods Post-hoc analysis of the ISAACC study, including 1701 patients admitted for ACS (NCT01335087)...
July 10, 2020: American Journal of Respiratory and Critical Care Medicine
#5
Dexter J Wiseman, Ryan S Thwaites, Peter J M Openshaw
No abstract text is available yet for this article.
July 9, 2020: American Journal of Respiratory and Critical Care Medicine
#6
Nicolas A Menzies, Meghan Bellerose, Christian Testa, Nicole Swartwood, Yelena Malyuta, Ted Cohen, Suzanne M Marks, Andrew N Hill, Anand A Date, Susan A Maloney, Sarah E Bowden, Ardath W Grills, Joshua A Salomon
RATIONALE: Most United States residents who develop tuberculosis were born abroad, and US TB incidence is increasingly driven by infection risks in other countries. OBJECTIVES: To estimate the potential impact of effective global TB control on health and economic outcomes in the United States. METHODS: We estimated outcomes using linked mathematical models of TB epidemiology in the United States and migrants' birth countries. A base-case scenario extrapolated country-specific TB incidence trends...
July 9, 2020: American Journal of Respiratory and Critical Care Medicine
#7
Gregory P Barton, Luis A Torres, Kara N Goss, Marlowe W Eldridge, Sean B Fain
No abstract text is available yet for this article.
July 8, 2020: American Journal of Respiratory and Critical Care Medicine
#8
Jay L Koyner
No abstract text is available yet for this article.
July 8, 2020: American Journal of Respiratory and Critical Care Medicine
#9
Thenappan Thenappan, E Kenneth Weir
No abstract text is available yet for this article.
July 8, 2020: American Journal of Respiratory and Critical Care Medicine
#10
Alejandro A Diaz
No abstract text is available yet for this article.
July 8, 2020: American Journal of Respiratory and Critical Care Medicine
#11
Christoph M Zehendner, Chanil Valasarajan, Astrid Werner, Jes-Niels Boeckel, Florian C Bischoff, David John, Tyler Weirick, Simone F Glaser, Oliver Rossbach, Nicolas Jaé, Shemsi Demolli, Fatemeh Khassafi, Ke Yuan, Vinicio A de Jesus Perez, Katharina M Michalik, Wei Chen, Werner Seeger, Andreas Guenther, Roxana M Wasnick, Shizuka Uchida, Andreas M Zeiher, Stefanie Dimmeler, Soni S Pullamsetti
RATIONALE: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored. OBJECTIVES: To elucidate the role of tyrosine kinase receptor inducing lncRNA (TYKRIL) as a regulator of p53/platelet-derived growth factor receptor β (PDGFRβ) signaling pathway and to investigate its role in PAH. MEASUREMENTS AND MAIN RESULTS: Using RNAseq data, TYKRIL was identified to be consistently upregulated in pericytes and pulmonary arterial smooth muscles cells (PASMCs) exposed to hypoxia and derived from IPAH patients...
July 7, 2020: American Journal of Respiratory and Critical Care Medicine
#12
Jeffrey J Swigris, David A Andrae, Tara Churney, Nathan Johnson, Mary Beth Scholand, Eric S White, Alison Matsui, Karina Raimundo, Christopher J Evans
RATIONALE: Several new drugs for idiopathic pulmonary fibrosis (IPF) are in development. Tools are needed to assess whether these drugs benefit patients on outcomes that matter most to them. Health-related quality of life (HRQL) is one such outcome. It is influenced by many factors, but symptoms and their impacts are two strong drivers. OBJECTIVES: To develop a questionnaire to assess symptoms, disease impacts and HRQL specifically for patients with IPF. METHODS: Working with the U...
July 7, 2020: American Journal of Respiratory and Critical Care Medicine
#13
Alexander G Mathioudakis, Markus Fally, Rola Hashad, Sean Knight, Timothy Felton, Jørgen Vestbo
No abstract text is available yet for this article.
July 7, 2020: American Journal of Respiratory and Critical Care Medicine
#14
Erik Melén, Gerard H Koppelman, Stefano Guerra
No abstract text is available yet for this article.
July 7, 2020: American Journal of Respiratory and Critical Care Medicine
#15
Anthony T Podany
No abstract text is available yet for this article.
July 7, 2020: American Journal of Respiratory and Critical Care Medicine
#16
Peter J Sterk, Anirban Sinha
No abstract text is available yet for this article.
July 6, 2020: American Journal of Respiratory and Critical Care Medicine
#17
Nilam S Mangalmurti, John P Reilly, Douglas B Cines, Christopher A Hunter, Nuala J Meyer, Andrew E Vaughan
No abstract text is available yet for this article.
July 6, 2020: American Journal of Respiratory and Critical Care Medicine
#18
Anna Kontos, Scott Willoughby, Kurt Lushington, James Martin, David Wabnitz, Jill Dorrian, Declan Kennedy
OBJECTIVE: Sleep disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation. This study compared whole blood impedance platelet aggregation in children diagnosed clinically as SDB warranting adenotonsillectomy and healthy controls. METHODS AND RESULTS: Thirty children clinically diagnosed by experienced pediatric otolaryngologists as having SDB warranting intervention were recruited from adenotonsillectomy waitlists and 20 healthy children from the community underwent overnight polysomnography to determine SDB severity (Obstructive Apnea Hypopnea Index (OAHI))...
July 6, 2020: American Journal of Respiratory and Critical Care Medicine
#19
Ian S Mudway, Thomas Sandstrom
No abstract text is available yet for this article.
July 6, 2020: American Journal of Respiratory and Critical Care Medicine
#20
Katharina Krenn, Petra Höbart, Marko Poglitsch, Adrien Croizé, Roman Ullrich
No abstract text is available yet for this article.
July 6, 2020: American Journal of Respiratory and Critical Care Medicine
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