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American Journal of Respiratory and Critical Care Medicine

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https://read.qxmd.com/read/31517507/transcriptomics-identify-a-unique-intermittent-hypoxia-mediated-profile-in-obstructive-sleep-apnea
#1
Chris D Turnbull, Lennard Yw Lee, Thomas Starkey, Dushendree Sen, John Stradling, Nayia Petousi
No abstract text is available yet for this article.
September 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31517504/reply-to-adherence-to-the-prevailing-sepsis-definition-is-quintessential-to-subphenotype-identification
#2
Sivasubramanium V Bhavani, Philip A Verhoef, Matthew M Churpek
No abstract text is available yet for this article.
September 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31517502/pulmonary-artery-filling-defects-beyond-pulmonary-embolism
#3
Sophie B Kermelly, François Côté, François Maltais
No abstract text is available yet for this article.
September 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31517501/adherence-to-the-prevailing-sepsis-definition-is-quintessential-to-subphenotype-identification
#4
Souvik Maitra, Sulagna Bhattacharjee
No abstract text is available yet for this article.
September 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31513754/the-association-between-supra-physiologic-arterial-oxygen-levels-and-mortality-in-critically-ill-patients-a-multi-centre-observational-cohort-study
#5
Edward Palmer, Benjamin Post, Roman Klapaukh, Giampiero Marra, Niall S MacCallum, David Brealey, Ari Ercole, Andrew Jones, Simon Ashworth, Peter Watkinson, Richard Beale, Stephen J Brett, J Duncon Young, Claire Black, Aasyiah Rashan, Daniel Martin, Mervyn Singer, Steve Harris
RATIONALE: There is conflicting evidence on harm related to exposure to supra-physiologic arterial oxygen tensions (hyperoxemia) in critically ill patients. OBJECTIVES: To examine the association between longitudinal exposure to hyperoxemia and mortality in patients admitted to intensive care units (ICUs) in 5 UK University Hospitals. METHODS: Retrospective cohort of ICU admissions between 31st January 2014 - 31st December 2018, from the National Institute of Health Research Critical Care Health Informatics Collaborative (CC-HIC)...
September 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31513751/beyond-the-lungs-systemic-manifestations-of-pulmonary-arterial-hypertension
#6
Nils P Nickel, Ke Yuan, Peter Dorfmuller, Steeve Provencher, Yen-Chun Lai, Sebastien Bonnet, Eric D Austin, Carl D Koch, Alison Morris, Frédéric Perros, David Montani, Roham T Zamanian, Vinicio A de Jesus Perez
Pulmonary arterial hypertension (PAH) is a disease characterized by progressive loss and remodeling of the pulmonary arteries resulting in right heart failure and death. Until recently, PAH was seen as a disease restricted to the pulmonary circulation. However, there is growing evidence that PAH patients also exhibit systemic vascular dysfunction, as evidenced by impaired brachial artery flow-mediated dilation, abnormal cerebral blood flow, skeletal myopathy, and intrinsic kidney disease. While some of these anomalies are partially due to right ventricular insufficiency, recent data support a mechanistic link to the genetic and molecular events behind PAH pathogenesis...
September 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31513748/balanced-crystalloids-or-0-9-saline-in-sepsis-beyond-reasonable-doubt
#7
Paul J Young
No abstract text is available yet for this article.
September 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31513747/pneumomediastinum-due-to-traumatic-rectal-perforation
#8
Eva M T Bots, Rogier A S Hoek
No abstract text is available yet for this article.
September 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31513746/copd-and-work-is-it-time-to-stop
#9
David Halpin
No abstract text is available yet for this article.
September 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31498684/the-2018-diagnosis-of-ipf-guidelines-surgical-lung-biopsy-in-probable-uip-is-not-mandatory
#10
Ganesh Raghu, Martine Remy-Jardin, Jeffrey Myers, Luca Richeldi, Kevin C Wilson
No abstract text is available yet for this article.
September 9, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31498653/platelet-extracellular-vesicles-drive-inflammasome-il1%C3%AE-dependent-lung-injury-in-sickle-cell-disease
#11
Ravi Vats, Tomasz Brzoska, Margaret F Bennewitz, Maritza A Jimenez, Tirthadipa Pradhan-Sundd, Egemen Tutuncuoglu, Jude Jonassaint, Edgar Gutierrez, Simon C Watkins, Sruti Shiva, Melanie Scott, Adrian E Morelli, Matthew D Neal, Gregory J Kato, Mark T Gladwin, Prithu Sundd
RATIONALE: Intra-erythrocytic polymerization of hemoglobin S promotes hemolysis and vaso-occlusive events in the microvasculature of sickle cell disease (SCD) patients. Although platelet-neutrophil aggregates-dependent vaso-occlusion is known to occur in the lung and contribute to acute chest syndrome, the etiological mechanisms that trigger lung injury are largely unknown. OBJECTIVES: To identify the innate-immune mechanism that promotes platelet-neutrophil aggregate-dependent lung vaso-occlusion and injury in SCD...
September 9, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31498651/beware-of-the-invisible-chest-wall-veins
#12
Bertin D Salguero, Adil Shujaat
No abstract text is available yet for this article.
September 9, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31496259/promotion-of-a-protease-antiprotease-imbalance-in-the-airways-through-chronic-vaping
#13
S Lorraine Martin, James A Reihill
No abstract text is available yet for this article.
September 8, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31491338/chemical-pneumonitis-caused-by-inhalation-of-white-phosphorus-fumes
#14
Akihito Okazaki, Yoshihiro Takeda, Yasuhiko Matsuda, Kazuhiko Shibata, Kazuo Kasahara
No abstract text is available yet for this article.
September 6, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31491335/endobronchial-valves-radiographically-protective-during-interstitial-lung-disease-exacerbation
#15
David M Becnel, Michael A Jantz, Hiren J Mehta
No abstract text is available yet for this article.
September 6, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31487200/no-association-between-genetic-loci-near-irf2-and-tbx1-and-acute-kidney-injury-in-the-critically-ill
#16
Iris Je Renken, Laura M Vilander, Mari A Kaunisto, Suvi T Vaara, Harold Snieder, Frederik Keus, Iwan C C Van Der Horst, Ville Pettilä
No abstract text is available yet for this article.
September 5, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31487198/cystic-fibrosis-lung-disease-and-immunometabolism-targeting-the-nlrp3-inflammasome
#17
André M Cantin
No abstract text is available yet for this article.
September 5, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31487195/plasma-srage-acts-as-genetically-regulated-causal-intermediate-in-sepsis-associated-ards
#18
Tiffanie K Jones, Rui Feng, V Eric Kerchberger, John P Reilly, Brian J Anderson, Michael G S Shashaty, Fan Wang, Thomas G Dunn, Thomas R Riley, Jason Abbott, Caroline A G Ittner, David C Christiani, Carmen Mikacenic, Mark M Wurfel, Lorraine B Ware, Carolyn S Calfee, Michael A Matthay, Jason D Christie, Nuala J Meyer
RATIONALE: Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of the soluble receptor for advanced glycation end products (sRAGE) strongly associate with ARDS risk. However, whether plasma sRAGE contributes causally to ARDS remains unknown. OBJECTIVES: Evaluate plasma sRAGE as a causal intermediate in ARDS by Mendelian Randomization (MR), a statistical method to infer causality using observational data. METHODS: We measured early plasma sRAGE in two critically ill populations with sepsis...
September 5, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31486671/is-pkm2-phosphorylation-prerequisite-for-oligomer-disassembly-in-pulmonary-arterial-hypertension
#19
Tatyana Novoyatleva, Nabham Rai, Norbert Weissmann, Friedrich Grimminger, Hossein A Ghofrani, Werner Seeger, Henning Gall, Ralph T Schermuly
No abstract text is available yet for this article.
September 5, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/31469583/impact-of-a-reduction-in-susceptibility-testing-for-pseudomonas-aeruginosa-in-a-cystic-fibrosis-program
#20
Mario C Ponce, Erik Svendsen, Lisa Steed, Patrick A Flume
No abstract text is available yet for this article.
August 30, 2019: American Journal of Respiratory and Critical Care Medicine
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