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American Journal of Respiratory and Critical Care Medicine

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https://read.qxmd.com/read/30893566/residential-exposure-to-outdoor-air-pollution-and-post-bronchodilator-lung-function-deficits-in-mid-adult-life
#1
Jennifer L Perret, Gayan Bowatte, Luke D Knibbs, David P Johns, Caroline J Lodge, Adrian J Lowe, Dinh S Bui, Melanie C Matheson, Bruce R Thompson, Graham G Giles, E Haydn Walters, Michael J Abramson, Shyamali C Dharmage
No abstract text is available yet for this article.
March 20, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30892057/peak-inspiratory-flow-rate-an-emerging-biomarker-in-copd
#2
Donald A Mahler
No abstract text is available yet for this article.
March 20, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30892053/reply-to-peak-inspiratory-flow-rate-an-emerging-biomarker-in-copd
#3
Ann Chen Wu, Blanca E Himes
No abstract text is available yet for this article.
March 20, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30888843/reply-to-confounding-factors-affecting-srage-as-biomarker-for-copd
#4
Robert A Stockley, David Halpin, Bartolome R Celli, Dave Singh
No abstract text is available yet for this article.
March 19, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30888839/extracellular-dna-neutrophil-extracellular-traps-and-inflammasome-activation-in-severe-asthma
#5
Marrah E Lachowicz-Scroggins, Eleanor M Dunican, Annabelle R Charbit, Wilfred Raymond, Mark R Looney, Michael C Peters, Erin D Gordon, Prescott G Woodruff, Emma Lefrançais, Brenda R Phillips, David T Mauger, Suzy A Comhair, Serpil C Erzurum, Mats W Johansson, Nizar N Jarjour, Andrea M Coverstone, Mario Castro, Annette T Hastie, Eugene R Bleecker, Merritt L Fajt, Sally E Wenzel, Elliot Israel, Bruce D Levy, John V Fahy
BACKGROUND: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NETs, and IL-1β in asthma is uncertain. METHODS: We measured sputum eDNA in induced sputum from 399 asthmatics in the Severe Asthma Research Program (SARP)-3 and in 94 healthy controls. We subdivided asthma subjects into eDNA-low and -high subgroups to compare outcomes of asthma severity and of neutrophil and inflammasome activation...
March 19, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30888837/blue-nose-sign-critical-care-presentation-of-toxic-ingestion
#6
J Francis Turner, Vimal Patel
No abstract text is available yet for this article.
March 19, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30888834/correlating-cftr-function-with-clinical-features-to-inform-precision-treatment-of-cystic-fibrosis
#7
Allison F McCague, Karen S Raraigh, Matthew J Pellicore, Emily F Davis-Marcisak, Taylor A Evans, Sangwoo T Han, Zhongzhou Lu, Anya T Joynt, Neeraj Sharma, Carlo Castellani, Joseph M Collaco, Mary Corey, Michelle H Lewis, Chris M Penland, Johanna M Rommens, Anne L Stephenson, Patrick R Sosnay, Garry R Cutting
RATIONALE: The advent of precision treatment for cystic fibrosis (CF) using small-molecule therapeutics has created a need to estimate potential clinical improvements attributable to increases in cystic fibrosis transmembrane conductance regulator (CFTR) function. OBJECTIVE: Derive CFTR function of a variety of CFTR genotypes and correlate with key clinical features (sweat chloride concentration, pancreatic exocrine status, and lung function) to develop benchmarks for assessing response to CFTR modulators...
March 19, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30888832/confounding-factors-affecting-srage-as-biomarker-for-copd
#8
Simon D Pouwels, Frank Klont, Rainer Bischoff, Nick H T Ten Hacken
No abstract text is available yet for this article.
March 19, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30884244/2018-ats-bear-cage-winning-proposal-cell-free-dna-to-improve-lung-transplant-outcomes
#9
Sean Agbor-Enoh
No abstract text is available yet for this article.
March 18, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30883192/loss-of-microbial-topography-between-oral-and-nasopharyngeal-microbiota-and-development-of-respiratory-infections-early-in-life
#10
Wing Ho Man, Melanie Clerc, Wouter A A de Steenhuijsen Piters, Marlies A van Houten, Mei Ling J N Chu, Jolanda Kool, Bart J F Keijser, Elisabeth A M Sanders, Debby Bogaert
RATIONALE: The respiratory microbiota is increasingly being appreciated as an important mediator in the susceptibility to childhood respiratory tract infections (RTIs). Pathogens are presumed to originate from the nasopharyngeal ecosystem. OBJECTIVES: To investigate the association between early-life respiratory microbiota and development of childhood RTIs. METHODS: In a prospective birth cohort (Microbiome Utrecht Infant Study: MUIS), we characterized the oral microbiota longitudinally from birth until six months of age of 112 infants (9 regular samples/subject) and compared them with nasopharyngeal microbiota using 16S-rRNA-based sequencing...
March 18, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30883191/the-combined-effects-of-frailty-and-cognitive-impairment-on-post-icu-disability-among-older-icu-survivors
#11
Lauren E Ferrante, Terrence E Murphy, Linda S Leo-Summers, Evelyne A Gahbauer, Margaret A Pisani, Thomas M Gill
No abstract text is available yet for this article.
March 18, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875247/long-term-azithromycin-reduces-haemophilus-influenzae-and-increases-antibiotic-resistance-in-severe-asthma
#12
Steven L Taylor, Lex E X Leong, Fredrick M Mobegi, Jocelyn M Choo, Steve Wesselingh, Ian A Yang, John W Upham, Paul N Reynolds, Sandra Hodge, Alan L James, Christine Jenkins, Matthew J Peters, Melissa Baraket, Guy B Marks, Peter G Gibson, Geraint B Rogers, Jodie L Simpson
Rationale The macrolide antibiotic, azithromycin, reduces exacerbations in adults with persistent symptomatic asthma. However, owing to the pleotropic properties of macrolides, unintended bacteriological consequences such as augmented pathogen colonization or dissemination of antibiotic-resistant organisms can occur, calling into question the long-term safety of azithromycin maintenance therapy. Objectives To assess the effects of azithromycin on the airway microbiota, pathogen abundance, and carriage of antibiotic-resistance genes...
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875244/changes-in-electrical-impedance-tomography-findings-of-icu-patients-during-rapid-infusion-of-a-fluid-bolus-a-prospective-observational-study
#13
Tobias Becher, Anna Wendler, Christine Eimer, Norbert Weiler, Inéz Frerichs
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875243/sustained-inflation-of-infant-lungs-from-bench-to-bedside-and-back-again
#14
Martin Keszler
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875238/could-adjunctive-pharmacology-mitigate-cardiovascular-consequences-of-osa
#15
Najib T Ayas, Glen E Foster, Neomi Shah, John Floras, Ismail Laher
Obstructive sleep apnea (OSA) is associated with adverse physiologic and biochemical sequelae including systemic inflammation, oxidative stress, increased chemoreceptor reflex activity, sympathetic nervous system activation, and endothelial dysfunction. In addition, compelling data strongly implicate OSA in the development of cardiovascular disease (CVD) including myocardial infarction and stroke. Yet in clinical trials, CPAP therapy alone did not reduce cardiovascular events in intention to treat analyses...
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875236/mid-term-reproducibility-of-chest-mri-in-adults-with-clinically-stable-cystic-fibrosis-and-chronic-obstructive-pulmonary-disease
#16
Mark O Wielpütz, Monika Eichinger, Sabine Wege, Ralf Eberhardt, Marcus A Mall, Hans-Ulrich Kauczor, Michael U Puderbach, Frank Risse, Claus P Heußel, Gudula Heußel
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875233/shifting-landscape-of-airway-infection-in-early-cystic-fibrosis
#17
Jordana E Hoppe, Scott D Sagel
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30871339/short-term-exposure-to-ambient-air-pollution-and-asthma-mortality
#18
Yuewei Liu, Jingju Pan, Hai Zhang, Chunxiang Shi, Guo Li, Zhe Peng, Jixuan Ma, Yun Zhou, Lan Zhang
RATIONALE: Short-term exposure to air pollution has been associated with asthma exacerbation and increased health-care use due to asthma, but its effect on asthma mortality remains largely unknown. OBJECTIVES: To quantitatively assess the association between short-term exposure to air pollution and asthma mortality. METHODS: We investigated 4,454 individuals who lived in Hubei province, China and died from asthma between 2013 and 2018. A case-crossover design and conditional logistic regression models were applied for data analyses...
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30865834/small-but-mighty-prenatal-ufp-exposure-linked-to-childhood-asthma-incidence
#19
Rosalind J Wright, Brent A Coull
No abstract text is available yet for this article.
March 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30865833/chasing-the-holy-grail-modulating-neutrophils-in-inflammatory-lung-disease
#20
Charlotte Summers
No abstract text is available yet for this article.
March 13, 2019: American Journal of Respiratory and Critical Care Medicine
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