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Journals American Journal of Respirator...

American Journal of Respiratory and Critical Care Medicine

https://read.qxmd.com/read/36455068/assessing-pretomanid-for-tuberculosis-apt-a-randomized-phase-2-trial-of-pretomanid-containing-regimens-for-drug-sensitive-tb-12-week-results
#1
JOURNAL ARTICLE
Kelly E Dooley, Bronwyn Hendricks, Nikhil Gupte, Grace Barnes, Kim Narunsky, Colleen Whitelaw, Tanya Smit, Elisa H Ignatius, Adine Friedman, Susan E Dorman, Rodney Dawson
RATIONALE: Pretomanid is a new nitroimidazole with proven treatment-shortening efficacy in drug-resistant tuberculosis. Pretomanid-rifamycin-pyrazinamide combinations are potent in mice but have not been tested clinically. Rifampicin, but not rifabutin, reduces pretomanid exposures. OBJECTIVE: Evaluate the safety and efficacy of pretomanid-rifamycin-pyrazinamide containing regimens among participants with drug-sensitive pulmonary tuberculosis. METHODS: Phase 2 twelve-week open-label randomized trial of isoniazid, pyrazinamide, plus (a) pretomanid and rifampicin (Arm 1); (b) pretomanid and rifabutin (Arm 2) or (c) rifampicin and ethambutol (standard of care, Arm 3)...
December 1, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36450136/reply-to-did-balanced-crystalloids-really-decrease-mortality-in-septic-patient
#2
JOURNAL ARTICLE
Fernando G Zampieri, Flavia R Machado, Alexandre B Cavalcanti
No abstract text is available yet for this article.
November 30, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36450133/did-balanced-crystalloids-really-decrease-mortality-in-septic-patient
#3
JOURNAL ARTICLE
Gildas Gueret
No abstract text is available yet for this article.
November 30, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36450096/morphological-differences-between-patient-self-inflicted-and-ventilator-induced-lung-injury-an-experimental-study
#4
JOURNAL ARTICLE
Pablo Cruces, Benjamín Erranz, Carlos González, Franco Diaz
No abstract text is available yet for this article.
November 30, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36449534/temperature-trajectory-subphenotypes-in-oncology-patients-with-neutropenia-and-suspected-infection
#5
JOURNAL ARTICLE
Nicole S Benzoni, Kyle A Carey, Alice F Bewley, Jeff Klaus, Brian M Fuller, Dana P Edelson, Matthew M Churpek, Sivasubramanium V Bhavani, Patrick G Lyons
RATIONALE: Despite etiologic and severity heterogeneity in neutropenic sepsis, management is often uniform. Understanding host response clinical subphenotypes might inform treatment strategies for neutropenic sepsis. OBJECTIVES: This retrospective two-hospital study analyzed whether temperature trajectory modeling could identify distinct, clinically relevant subphenotypes among neutropenic oncology patients with suspected infection. METHODS: Among adult oncologic admissions with neutropenia and blood cultures within 24 hours, a previously validated model classified patients' initial 72-hour temperature trajectories into one of four subphenotypes...
November 30, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36449444/bronchoscopic-lung-volume-reduction-complicated-by-electrical-alternans
#6
JOURNAL ARTICLE
Kurt Hu, Elise M Jondall, Jonathan S Kurman, Bryan S Benn
No abstract text is available yet for this article.
November 30, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36449443/massive-bilateral-coronary-air-embolism-following-lung-biopsy
#7
JOURNAL ARTICLE
Jean Rabet, Cyril Sargentini, Corentin Aubourg, Sylvain Lemoine, Marie Sirima Marx, Emmanuel Rineau
No abstract text is available yet for this article.
November 30, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36449386/intermittent-hypoxemia-and-bronchopulmonary-dysplasia-with-pulmonary-hypertension-in-preterm-infants
#8
JOURNAL ARTICLE
Samuel J Gentle, Colm P Travers, Arie Nakhmani, Premananda Indic, Waldemar A Carlo, Namasivayam Ambalavanan
RATIONALE: Bedside biomarkers that allow early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) are critically important given the higher risk of death in these infants. OBJECTIVE: We hypothesized that infants with BPD-PH have patterns of intermittent hypoxemia that differ from infants with BPD without pulmonary hypertension. METHODS: We conducted a matched case-control study of extremely preterm infants 22w 0d to 28w 6d born between 2018 and 2020 at the University of Alabama at Birmingham...
November 30, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36413774/is-the-upa-pai-1-ratio-a-marker-of-sonographic-septations-in-pleural-infection
#9
JOURNAL ARTICLE
Taro Yasuma, Corina N D'Alessandro-Gabazza, Tetsu Kobayashi, Esteban C Gabazza, Hajime Fujimoto
No abstract text is available yet for this article.
November 22, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36413773/reply-to-is-the-upa-pai-1-ratio-a-marker-of-sonographic-septations-in-pleural-infection
#10
JOURNAL ARTICLE
Eihab O Bedawi, Nikolaos I Kanellakis, Najib M Rahman
No abstract text is available yet for this article.
November 22, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36413362/the-intersection-between-autoimmunity-macrophage-dysfunction-endotype-and-exacerbations-in-severe-asthma
#11
JOURNAL ARTICLE
Ryan C Murphy, Eric D Morrell, Teal S Hallstrand
No abstract text is available yet for this article.
November 22, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36409973/plasticity-of-individual-lung-function-states-from-childhood-to-adulthood
#12
JOURNAL ARTICLE
Gang Wang, Jenny Hallberg, Rosa Faner, Hans-Jacob Koefoed, Simon Kebede Merid, Susanna Klevebro, Sophia Björkander, Olena Gruzieva, Göran Pershagen, Marianne van Hage, Stefano Guerra, Matteo Bottai, Antonios Georgelis, Ulrike Gehring, Anna Bergström, Judith M Vonk, Inger Kull, Gerard H Koppelman, Alvar Agusti, Erik Melén
RATIONALE: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. OBJECTIVES: To explore the plasticity of individual lung function states during childhood. METHODS: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains...
November 21, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36399668/cancer-or-not-cancer-that-is-the-question
#13
JOURNAL ARTICLE
Andrew Bush, Andrew G Nicholson
No abstract text is available yet for this article.
November 18, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36399661/heterogeneity-of-airway-smooth-muscle-remodelling-in-asthma
#14
JOURNAL ARTICLE
Alan L James, Graham M Donovan, Francis H Y Green, Thais Mauad, Michael J Abramson, Alvenia Cairncross, Peter B Noble, John G Elliot
RATIONALE: Ventilatory defects in asthma are heterogeneous and may represent the distribution of airway smooth muscle (ASM) remodelling. OBJECTIVES: To determine the distribution of ASM remodelling in mild-severe asthma. METHODS: The ASM area was measured in 9 airway levels in 3 bronchial pathways in cases of nonfatal (n=30) and fatal asthma (n=20) and compared with controls without asthma (n=30). Correlations of ASM area within and between bronchial pathways were calculated...
November 18, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36395487/reply-to-positive-and-negative-pressure-ventilation-characterized-by-local-and-global-pulmonary-mechanics
#15
JOURNAL ARTICLE
Mona Eskandari
No abstract text is available yet for this article.
November 17, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36395483/positive-and-negative-pressure-ventilation-characterized-by-local-and-global-pulmonary-mechanics
#16
JOURNAL ARTICLE
Shoujin Dong, Wenting Lu, Yongsheng Wang
No abstract text is available yet for this article.
November 17, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36384022/defining-ards-again-a-plea-for-honesty
#17
JOURNAL ARTICLE
Martin J Tobin
No abstract text is available yet for this article.
November 16, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36384004/reply-to-defining-ards-again-a-plea-for-honesty
#18
JOURNAL ARTICLE
V Marco Ranieri, Gordon Rubenfeld, Arthur S Slutsky
No abstract text is available yet for this article.
November 16, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36383981/improved-survival-for-patients-with-systemic-sclerosis-associated-pulmonary-arterial-hypertension-for-real
#19
JOURNAL ARTICLE
Panagiota Xanthouli
No abstract text is available yet for this article.
November 16, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36383197/a-race-neutral-approach-to-the-interpretation-of-lung-function-measurements
#20
JOURNAL ARTICLE
Cole Bowerman, Nirav R Bhatka, Danny Brazzale, Brendan R Cooper, Julie Cooper, Laura Gochicoa-Rangel, Jeffrey Haynes, David A Kaminsky, Le Thi Tuyet Lan, Refiloe Masekela, Meredith C McCormack, Irene Steenbruggen, Sanja Stanojevic
RATIONALE: The use of self-reported race/ethnicity to interpret lung function measurements has historically assumed that the observed differences in lung function between racial and ethnic group were due to thoracic cavity size differences relative to standing height. Very few studies have considered the influence of environmental and social determinants on pulmonary function. Consequently, the use of race and ethnicity specific reference equations may further marginalize disadvantaged populations...
November 16, 2022: American Journal of Respiratory and Critical Care Medicine
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