Most recent papers in the journal American Journal of Respiratory and Critical Care Medicine

#1

JOURNAL ARTICLE

Who Modifies the Modifiers: A High Resolution View of the Genetic Modifiers of Cystic Fibrosis.

Sean Kalra, Michael H Cho

No abstract text is available yet for this article.

36961916

March 24, 2023: American Journal of Respiratory and Critical Care Medicine

#2

JOURNAL ARTICLE

AJRCCM: Strength in Breadth.

Andrew Bush, Fernando J Martinez, Laurent J Brochard, Sanjay H Chotirmall, MeiLan K Han

No abstract text is available yet for this article.

36961915

March 24, 2023: American Journal of Respiratory and Critical Care Medicine

#3

JOURNAL ARTICLE

Patient Self-inflicted and Ventilator-induced Lung Injury: Two Sides of the Same Coin?

Joaquin Pérez

No abstract text is available yet for this article.

36952680

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#4

JOURNAL ARTICLE

Reply to: Patient Self-Inflicted and Ventilator-Induced Lung Injury: Two Sides of the Same Coin?

Pablo Cruces, Benjamín Erranz, Franco Diaz

No abstract text is available yet for this article.

36952677

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#5

JOURNAL ARTICLE

Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33 Dependent Inflammation.

Daniel P Cook, Christopher M Thomas, Ashley Y Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N Gibson-Corley, Vasiliy V Polosukhin, Allison E Norlander, Dawn C Newcomb, David A Stoltz, R Stokes Peebles

Rationale: Type 2 inflammation has been described in people with cystic fibrosis (CF). Whether loss of cystic fibrosis transmembrane conductance regulator (CFTR) function contributes directly to a type 2 inflammatory response has not been fully defined. Objectives: The potent alarmin IL-33 has emerged as a critical regulator of type 2 inflammation. We tested the hypothesis that CFTR-deficiency increases IL-33 expression/release and deletion of IL-33 reduces allergen-induced inflammation in the CF lung. Methods: Human airway epithelial cells (AECs) grown from non-CF and CF cell lines and Cftr+/+ and Cftr-/- mice, were used in this study...

36952660

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#6

JOURNAL ARTICLE

Individualized Treatment Effects: Machine Learning Can Revolutionalize Observations, but Let's Understand What We Are Observing.

Jarrod M Mosier

No abstract text is available yet for this article.

36952659

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#7

JOURNAL ARTICLE

Variability in MUC5B Expression Is Dependent on Genotype and Endotype in Idiopathic Pulmonary Fibrosis.

Auyon J Ghosh, Matthew Moll, Brian D Hobbs, Jonathan Cardwell, Aabida Saferali, Peter J Castaldi, Michael H Cho, Edwin K Silverman, Ivana V Yang, Craig P Hersh

No abstract text is available yet for this article.

36952240

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#8

JOURNAL ARTICLE

Ascertainment Bias in TB Treatment Trials: Can Systematic Assessment of Objective Endpoints Solve It?

Carole D Mitnick, Andrew J Nunn

No abstract text is available yet for this article.

36952239

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#9

JOURNAL ARTICLE

2022 American Thoracic Society BEAR Cage Winning Proposal: Passive Respiratory Exposure Detection - Investigation of COPD Triggers (PREDICT).

John C Huston

No abstract text is available yet for this article.

36952238

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#10

JOURNAL ARTICLE

Vascular BMPRs Strike Out the Rolling Ball of Fibrosis.

Patricia L Brazee, Rachel S Knipe

No abstract text is available yet for this article.

36952237

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#11

JOURNAL ARTICLE

The Cellular Landscape of CTEPH Revealed by Single Cell Sequencing: Therapeutic Implications?

Rozenn Quarck, Harm Jan Bogaard, Marion Delcroix

No abstract text is available yet for this article.

36952236

March 23, 2023: American Journal of Respiratory and Critical Care Medicine

#12

JOURNAL ARTICLE

Improving ARDS Diagnosis: Is Lung Ultrasound the Answer?

Lorraine B Ware

No abstract text is available yet for this article.

36943197

March 21, 2023: American Journal of Respiratory and Critical Care Medicine

#13

JOURNAL ARTICLE

Machine Learning Algorithm to Improve Cohort Identification in Interstitial Lung Disease.

Erica Farrand, Oksana Gologorskaya, Hunter Mills, Lakshmi Radhakrishnan, Harold R Collard, Atul J Butte

No abstract text is available yet for this article.

36943196

March 21, 2023: American Journal of Respiratory and Critical Care Medicine

#14

JOURNAL ARTICLE

Pediatric Ventilator Liberation Guideline: Should the T-Piece and Automatic Tube Compensation Be Ignored in the Spontaneous Breathing Trial?

Merve Havan, Hacer Uçmak, Tanıl Kendirli

No abstract text is available yet for this article.

36930960

March 17, 2023: American Journal of Respiratory and Critical Care Medicine

#15

JOURNAL ARTICLE

Reply to: Pediatric Ventilator Liberation Guideline: Should the T-Piece and Automatic Tube Compensation Be Ignored in the Spontaneous Breathing Trial?

Samer Abu-Sultaneh, Robinder G Khemani

No abstract text is available yet for this article.

36930956

March 17, 2023: American Journal of Respiratory and Critical Care Medicine

#16

JOURNAL ARTICLE

Reply to: PCSK6: The endogenous PAR-1 agonist driving pulmonary fibrosis?

Justin M Oldham, Richard J Allen, Jose M Lorenzo-Salazar, Carlos Flores, Louise V Wain, Imre Noth

No abstract text is available yet for this article.

36927480

March 16, 2023: American Journal of Respiratory and Critical Care Medicine

#17

JOURNAL ARTICLE

PCSK6: The Endogenous PAR-1 Agonist Driving Pulmonary Fibrosis?

C Arnold Spek, JanWillem Duitman

No abstract text is available yet for this article.

36927336

March 16, 2023: American Journal of Respiratory and Critical Care Medicine

#18

JOURNAL ARTICLE

SOX17 at the Intersection of Sex, Transcription, and Metabolism in Pulmonary Hypertension.

Susan Lin, David B Frank

No abstract text is available yet for this article.

36927296

March 16, 2023: American Journal of Respiratory and Critical Care Medicine

#19

JOURNAL ARTICLE

Lung Cryobiopsy versus Surgical Lung Biopsy for Diagnosing Fibrotic Interstitial Lung Disease: Still Looking for the "Perfect" Trial.

Rocco Trisolini

No abstract text is available yet for this article.

36921148

March 15, 2023: American Journal of Respiratory and Critical Care Medicine

#20

JOURNAL ARTICLE

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole Genome Analysis of 7,840 Patients.

Yi-Hui Zhou, Paul J Gallins, Rhonda G Pace, Hong Dang, Melis A Aksit, Elizabeth E Blue, Kati J Buckingham, Joseph M Collaco, Anna V Faino, William W Gordon, Kurt N Hetrick, Hua Ling, Weifang Liu, Frankline M Onchiri, Kymberleigh Pagel, Elizabeth W Pugh, Karen S Raraigh, Margaret Rosenfeld, Quan Sun, Jia Wen, Yun Li, Harriet Corvol, Lisa J Strug, Michael J Bamshad, Scott M Blackman, Garry R Cutting, Ronald L Gibson, Wanda K O'Neal, Fred A Wright, Michael R Knowles

RATIONALE: Lung disease is the major cause of morbidity and mortality in persons with cystic fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR genetic influence. Identification of genetic modifiers has prognostic and therapeutic importance. OBJECTIVES: Identify genetic modifier loci and genes/pathways associated with pulmonary disease severity. METHODS: Whole genome sequencing (WGS) data on 4,248 unique pwCF with pancreatic insufficiency (PI) and lung function measures were combined with imputed genotypes from an additional 3,592 PI patients from the US, Canada, and France...

36921087

March 15, 2023: American Journal of Respiratory and Critical Care Medicine

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