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Journals American Journal of Respirator...

American Journal of Respiratory and Critical Care Medicine

https://read.qxmd.com/read/38760016/restored-cytokine-producing-capacities-of-mucosal-associated-invariant-t-cells-in-pediatric-cystic-fibrosis-patients-treated-with-elexacaftor-tezacaftor-ivacaftor
#1
JOURNAL ARTICLE
Emmanuelle Bardin, Céline Dietrich, Messaouda Attailia, Agnès Ferroni, Anne Jamet, Guillaume Lezmi, Isabelle Sermet-Gaudelus, Maria Leite-de-Moraes
No abstract text is available yet for this article.
May 17, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38760004/reverse-triggering-rt-during-vv-ecmo-magnitude-of-the-rt-effort-mediated-by-inspiratory-pressure
#2
JOURNAL ARTICLE
Julien P van Oosten, Irene Telias, Nico Goedendorp, Henrik Endeman, Diederik A M P J Gommers, Annemijn H Jonkman
No abstract text is available yet for this article.
May 17, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38760002/unraveling-the-immune-profile-in-emphysema-using-single-cell-and-imaging-mass-spectrometry
#3
JOURNAL ARTICLE
Ken R Bracke
No abstract text is available yet for this article.
May 17, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38754132/a-bispecific-monoclonal-antibody-targeting-psl-and-pcrv-enhances-neutrophil-mediated-killing-of-pseudomonas-aeruginosa-in-patients-with-bronchiectasis
#4
JOURNAL ARTICLE
Merete B Long, Amy Gilmour, Margaret Kehl, David Tabor, Ashley E Keller, Paul Warrener, Vancheswaran Gopalakrishnan, Sanna Rosengren, Megan L Crichton, Eve McIntosh, Yan Hui Giam, Holly R Keir, Wayne Brailsford, Rod Hughes, Maria G Belvisi, Bret R Sellman, Antonio DiGiandomenico, James D Chalmers
RATIONALE AND OBJECTIVES: Pseudomonas aeruginosa infection is associated with worse outcomes in bronchiectasis. Impaired neutrophil antimicrobial responses contribute to bacterial persistence. Gremubamab is a bivalent, bispecific monoclonal antibody targeting Psl exopolysaccharide and the type 3 secretion system component PcrV. This study evaluated the efficacy of gremubamab to enhance killing of P.aeruginosa by neutrophils from bronchiectasis patients and to prevent P.aeruginosa -associated cytotoxicity...
May 16, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38748562/essential-mixed-cryoglobulinemic-vasculitis-sole-onset-with-acute-respiratory-distress-syndrome
#5
JOURNAL ARTICLE
Shigeto Horiuchi, Makoto Hibino, Shunichi Tobe, Kazunari Maeda, Riko Kamada, Shigehiro Watanabe, Tetsuri Kondo
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38748223/a-promising-biomarker-for-pulmonary-sarcoidosis-that-must-cross-the-finish-line
#6
JOURNAL ARTICLE
Lisa Maier, Wonder P Drake
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38747680/pulmonary-hypertension-and-anastrozole-phantom-a-randomized-double-blind-placebo-controlled-trial
#7
JOURNAL ARTICLE
Steven M Kawut, Rui Feng, Susan S Ellenberg, Roham Zamanian, Todd Bull, Murali Chakinala, Stephen C Mathai, Anna Hemnes, Grace Lin, Margaret Doyle, Ruth Andrew, Margaret MacLean, Ioannis Stasinopoulos, Eric Austin, Angela DeMichele, Haochang Shou, Jasleen Minhas, Nianfu Song, Jude Moutchia, Corey E Ventetuolo
RATIONALE: Inhibition of aromatase with anastrozole reduces pulmonary hypertension in experimental models. OBJECTIVES: We aimed to determine whether anastrozole improved six-minute walk distance (6MWD) at six months in pulmonary arterial hypertension (PAH). METHODS: We performed a randomized, double-blind, placebo-controlled Phase II clinical trial of anastrozole in subjects with PAH at seven centers. Eighty-four post-menopausal women and men with PAH were randomized in a 1:1 ratio to receive anastrozole 1 mg or placebo by mouth daily, stratified by sex using permuted blocks of variable sizes...
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38747674/microscopic-small-airway-abnormalities-identified-in-early-idiopathic-pulmonary-fibrosis-in-vivo-using-endobronchial-optical-coherence-tomography
#8
JOURNAL ARTICLE
Sarita R Berigei, Sreyankar Nandy, Satomi Yamamoto, Rebecca A Raphaely, Amalia DeCoursey, Jaeyul Lee, Amita Sharma, Hugh G Auchincloss, Henning Gaissert, Michael Lanuti, Harald C Ott, Uma M Sachdeva, Cameron D Wright, Sophia H Zhao, Robert W Hallowell, Barry S Shea, Ashok Muniappan, Colleen M Keyes, Lida P Hariri
RATIONALE: Idiopathic pulmonary fibrosis (IPF) affects subpleural lung, but is considered to spare small airways. Micro-CT studies demonstrated small airway reduction in end-stage IPF explanted lungs, raising questions about small airway involvement in early-stage disease. Endobronchial optical coherence tomography (EB-OCT) is a volumetric imaging modality that detects microscopic features from subpleural to proximal airways. We use EB-OCT to evaluate small airways in early IPF and control subjects in vivo ...
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38747649/imaging-to-advance-bronchiectasis-phenotyping
#9
JOURNAL ARTICLE
Diego J Maselli, Alejandro A Diaz
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38747644/the-heterogeneous-world-of-non-tuberculous-mycobacteria-in-bronchiectasis
#10
JOURNAL ARTICLE
Miguel Angel Martinez-Garcia
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38747640/extracorporeal-blood-flow-rate-target-the-right-thing
#11
JOURNAL ARTICLE
Ghislaine Douflé, Bhushan H Katira
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38717794/reversal-of-bronchiectasis-in-children-early-intervention-may-stop-the-vicious-circle
#12
JOURNAL ARTICLE
Pierre-Régis Burgel, Andrew Bush
No abstract text is available yet for this article.
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38717443/single-cell-profiling-reveals-immune-aberrations-in-progressive-idiopathic-pulmonary-fibrosis
#13
JOURNAL ARTICLE
Avraham Unterman, Amy Y Zhao, Nir Neumark, Jonas C Schupp, Farida Ahangari, Carlos Cosme, Prapti Sharma, Jasper Flint, Yan Stein, Changwan Ryu, Genta Ishikawa, Tomokazu S Sumida, Jose L Gomez, Jose D Herazo-Maya, Charles S Dela Cruz, Erica L Herzog, Naftali Kaminski
RATIONALE: Changes in peripheral blood cell populations have been observed but not detailed at single-cell resolution in idiopathic pulmonary fibrosis (IPF). OBJECTIVES: To provide an atlas of the changes in the peripheral immune system in stable and progressive IPF. METHODS: Peripheral blood mononuclear cells (PBMCs) from IPF patients and controls were profiled using 10x Chromium 5' single-cell RNA sequencing (scRNA-seq). Flow cytometry was used for validation...
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38717359/deciphering-idiopathic-bronchiectasis-one-gene-at-a-time
#14
JOURNAL ARTICLE
Amjad Horani
No abstract text is available yet for this article.
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38717347/endotypes-of-exacerbation-in-bronchiectasis-an-observational-cohort-study
#15
JOURNAL ARTICLE
Yonghua Gao, Hollian Richardson, Alison J Dicker, Alun Barton, Elena Kuzmanova, Michal Shteinberg, Lidia Perea, Pieter C Goeminne, Erin Cant, Chandani Hennayake, Jennifer Pollock, Hani Abo Leyah, Hayoung Choi, Eva Polverino, Francesco Blasi, Tobias Welte, Stefano Aliberti, Merete Long, Amelia Shoemark, Oriol Sibila, Jeffrey T J Huang, James D Chalmers
RATIONALE: Bronchiectasis is characterised by acute exacerbations but the biological mechanisms underlying these events is poorly characterised. Objectives To investigate the inflammatory and microbial characteristics of exacerbations of bronchiectasis. METHODS: 120 patients with bronchiectasis were enrolled and presented with acute exacerbations within 12 months. Spontaneous sputum samples were obtained during a period of clinical stability and again at exacerbation prior to receipt of antibiotic treatment...
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38713064/spondylothoracic-dysostosis-crab-like-rib-cage-configuration-in-a-jarcho-levin-syndrome-neonate
#16
JOURNAL ARTICLE
Kimberly D García-Irizarry, Joseph J Perez-Ortiz, Jesús M Meléndez-Montañez, Wilfredo De Jesús-Rojas
No abstract text is available yet for this article.
May 7, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38712994/the-impact-of-tobacco-smoking-in-bronchiectasis-data-from-the-united-states-bronchiectasis-and-ntm-research-registry
#17
JOURNAL ARTICLE
Pamela J McShane, Amanda E Brunton, Radmila Choate, Meghan Marmor, Christopher J Richards, George M Solomon, Diego J Maselli, Colin Swenson, Timothy R Aksamit, Mark L Metersky
No abstract text is available yet for this article.
May 7, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38712992/mechanical-thrombectomy-in-a-single-lung-transplant-recipient-a-salvage-case
#18
JOURNAL ARTICLE
Hugo Clermidy, Salim Si-Mohamed, Cyril Prieur, Claire Merveilleux du Vignaux, Philippe Douek, François Tronc
No abstract text is available yet for this article.
May 7, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38701495/exploring-definitions-and-predictors-of-severe-asthma-clinical-remission-post-biologic-in-adults
#19
JOURNAL ARTICLE
Luis Perez-de-Llano, Ghislaine Scelo, Trung N Tran, Tham T Le, Malin Faregås, Borja G Cosio, Matthew Peters, Paul E Pfeffer, Mona Al-Ahmad, Riyad O Al-Lehebi, Alan Altraja, Celine Bergeron, Leif H Bjermer, Anne S Bjerrum, Lakmini Bulathsinhala, John Busby, Diana J Cano Rosales, Giorgio W Canonica, Victoria A Carter, Jeremy Charriot, George C Christoff, Eve J Denton, Delbert R Dorscheid, Maria J Fernandez Sanchez, João A Fonseca, Peter G Gibson, Celine Y Y Goh, Liam G Heaney, Enrico Heffler, Mark Hew, Takashi Iwanaga, Rohit Katial, Mariko S Koh, Piotr Kuna, Désirée E S Larenas-Linnemann, Lauri Lehtimäki, Bassam Mahboub, Neil Martin, Hisako Matsumoto, Andrew N Menzies-Gow, Nikolaos G Papadopoulos, Todor A Popov, Celeste M Porsbjerg, Pujan Patel, Chin K Rhee, Mohsen Sadatsafavi, Camille Taillé, Carlos A Torres-Duque, Ming-Ju Tsai, Charlotte S Ulrik, John W Upham, Anna von Bülow, Eileen Wang, Michael E Wechsler, David B Price
RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify the proportion of adults with severe asthma achieving multi-domain-defined remission post-biologic-initiation and identify pre-biologic characteristics associated with achieving remission which may be used to predict it. METHODS: This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry...
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38701491/reply-to-zijlstra-resilience-and-stress-are-heterogenic-too-we-should-act-accordingly
#20
JOURNAL ARTICLE
Elie Azoulay, Frédéric Pochard, Laurent Argaud, Nancy Kentish-Barnes
No abstract text is available yet for this article.
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
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