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American Journal of Respiratory and Critical Care Medicine

https://read.qxmd.com/read/36961916/who-modifies-the-modifiers-a-high-resolution-view-of-the-genetic-modifiers-of-cystic-fibrosis
#1
JOURNAL ARTICLE
Sean Kalra, Michael H Cho
No abstract text is available yet for this article.
March 24, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36961915/ajrccm-strength-in-breadth
#2
JOURNAL ARTICLE
Andrew Bush, Fernando J Martinez, Laurent J Brochard, Sanjay H Chotirmall, MeiLan K Han
No abstract text is available yet for this article.
March 24, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952680/patient-self-inflicted-and-ventilator-induced-lung-injury-two-sides-of-the-same-coin
#3
JOURNAL ARTICLE
Joaquin Pérez
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952677/reply-to-patient-self-inflicted-and-ventilator-induced-lung-injury-two-sides-of-the-same-coin
#4
JOURNAL ARTICLE
Pablo Cruces, Benjamín Erranz, Franco Diaz
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952660/cystic-fibrosis-reprograms-airway-epithelial-il-33-release-and-licenses-il-33-dependent-inflammation
#5
JOURNAL ARTICLE
Daniel P Cook, Christopher M Thomas, Ashley Y Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N Gibson-Corley, Vasiliy V Polosukhin, Allison E Norlander, Dawn C Newcomb, David A Stoltz, R Stokes Peebles
Rationale: Type 2 inflammation has been described in people with cystic fibrosis (CF). Whether loss of cystic fibrosis transmembrane conductance regulator (CFTR) function contributes directly to a type 2 inflammatory response has not been fully defined. Objectives: The potent alarmin IL-33 has emerged as a critical regulator of type 2 inflammation. We tested the hypothesis that CFTR-deficiency increases IL-33 expression/release and deletion of IL-33 reduces allergen-induced inflammation in the CF lung. Methods: Human airway epithelial cells (AECs) grown from non-CF and CF cell lines and Cftr+/+ and Cftr-/- mice, were used in this study...
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952659/individualized-treatment-effects-machine-learning-can-revolutionalize-observations-but-let-s-understand-what-we-are-observing
#6
JOURNAL ARTICLE
Jarrod M Mosier
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952240/variability-in-muc5b-expression-is-dependent-on-genotype-and-endotype-in-idiopathic-pulmonary-fibrosis
#7
JOURNAL ARTICLE
Auyon J Ghosh, Matthew Moll, Brian D Hobbs, Jonathan Cardwell, Aabida Saferali, Peter J Castaldi, Michael H Cho, Edwin K Silverman, Ivana V Yang, Craig P Hersh
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952239/ascertainment-bias-in-tb-treatment-trials-can-systematic-assessment-of-objective-endpoints-solve-it
#8
JOURNAL ARTICLE
Carole D Mitnick, Andrew J Nunn
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952238/2022-american-thoracic-society-bear-cage-winning-proposal-passive-respiratory-exposure-detection-investigation-of-copd-triggers-predict
#9
JOURNAL ARTICLE
John C Huston
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952237/vascular-bmprs-strike-out-the-rolling-ball-of-fibrosis
#10
JOURNAL ARTICLE
Patricia L Brazee, Rachel S Knipe
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36952236/the-cellular-landscape-of-cteph-revealed-by-single-cell-sequencing-therapeutic-implications
#11
JOURNAL ARTICLE
Rozenn Quarck, Harm Jan Bogaard, Marion Delcroix
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36943197/improving-ards-diagnosis-is-lung-ultrasound-the-answer
#12
JOURNAL ARTICLE
Lorraine B Ware
No abstract text is available yet for this article.
March 21, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36943196/machine-learning-algorithm-to-improve-cohort-identification-in-interstitial-lung-disease
#13
JOURNAL ARTICLE
Erica Farrand, Oksana Gologorskaya, Hunter Mills, Lakshmi Radhakrishnan, Harold R Collard, Atul J Butte
No abstract text is available yet for this article.
March 21, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36930960/pediatric-ventilator-liberation-guideline-should-the-t-piece-and-automatic-tube-compensation-be-ignored-in-the-spontaneous-breathing-trial
#14
JOURNAL ARTICLE
Merve Havan, Hacer Uçmak, Tanıl Kendirli
No abstract text is available yet for this article.
March 17, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36930956/reply-to-pediatric-ventilator-liberation-guideline-should-the-t-piece-and-automatic-tube-compensation-be-ignored-in-the-spontaneous-breathing-trial
#15
JOURNAL ARTICLE
Samer Abu-Sultaneh, Robinder G Khemani
No abstract text is available yet for this article.
March 17, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36927480/reply-to-pcsk6-the-endogenous-par-1-agonist-driving-pulmonary-fibrosis
#16
JOURNAL ARTICLE
Justin M Oldham, Richard J Allen, Jose M Lorenzo-Salazar, Carlos Flores, Louise V Wain, Imre Noth
No abstract text is available yet for this article.
March 16, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36927336/pcsk6-the-endogenous-par-1-agonist-driving-pulmonary-fibrosis
#17
JOURNAL ARTICLE
C Arnold Spek, JanWillem Duitman
No abstract text is available yet for this article.
March 16, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36927296/sox17-at-the-intersection-of-sex-transcription-and-metabolism-in-pulmonary-hypertension
#18
JOURNAL ARTICLE
Susan Lin, David B Frank
No abstract text is available yet for this article.
March 16, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36921148/lung-cryobiopsy-versus-surgical-lung-biopsy-for-diagnosing-fibrotic-interstitial-lung-disease-still-looking-for-the-perfect-trial
#19
JOURNAL ARTICLE
Rocco Trisolini
No abstract text is available yet for this article.
March 15, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/36921087/genetic-modifiers-of-cystic-fibrosis-lung-disease-severity-whole-genome-analysis-of-7-840-patients
#20
JOURNAL ARTICLE
Yi-Hui Zhou, Paul J Gallins, Rhonda G Pace, Hong Dang, Melis A Aksit, Elizabeth E Blue, Kati J Buckingham, Joseph M Collaco, Anna V Faino, William W Gordon, Kurt N Hetrick, Hua Ling, Weifang Liu, Frankline M Onchiri, Kymberleigh Pagel, Elizabeth W Pugh, Karen S Raraigh, Margaret Rosenfeld, Quan Sun, Jia Wen, Yun Li, Harriet Corvol, Lisa J Strug, Michael J Bamshad, Scott M Blackman, Garry R Cutting, Ronald L Gibson, Wanda K O'Neal, Fred A Wright, Michael R Knowles
RATIONALE: Lung disease is the major cause of morbidity and mortality in persons with cystic fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR genetic influence. Identification of genetic modifiers has prognostic and therapeutic importance. OBJECTIVES: Identify genetic modifier loci and genes/pathways associated with pulmonary disease severity. METHODS: Whole genome sequencing (WGS) data on 4,248 unique pwCF with pancreatic insufficiency (PI) and lung function measures were combined with imputed genotypes from an additional 3,592 PI patients from the US, Canada, and France...
March 15, 2023: American Journal of Respiratory and Critical Care Medicine
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