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Journals
American Journal of Respirator...
American Journal of Respiratory and Critical Care Medicine
#1
Michaël Mekeirele, Valérie Broeckhoven, Alexander Wilmer, Tim Balthazar
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
#2
Sara Op de Beeck, Andrew Wellman, Marijke Dieltjens, Kingman P Strohl, Marc Willemen, Paul H Van de Heyning, Johan A Verbraecken, Olivier M Vanderveken, Scott A Sands
RATIONALE: Approximately a third of patients with obstructive sleep apnea (OSA) treated with hypoglossal nerve stimulation (HGNS) therapy are incomplete responders, despite careful patient selection based on baseline characteristics and drug-induced sleep endoscopy. Here we use polysomnographic endotyping to assess the pathophysiological mechanisms underlying favorable versus incomplete responses to HGNS therapy. METHODS: Baseline polysomnography data of the STAR trial were included...
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
#3
Brian Lipworth, Rory Chan, Chris RuiWen Kuo
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
#4
Angela M Moran, Sanjay Ramakrishnan, Catherine A Borg, Clare M Connolly, Simon Couillard, Christine M Mwasuku, Ian D Pavord, Timothy S C Hinks, Lauri Lehtimäki
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
#5
Matthias Griese, Stefano Costa, Rachel W Linnemann, Marcus A Mall, Edward F McKone, Deepika Polineni, Bradley S Quon, Felix C Ringshausen, Jennifer L Taylor-Cousar, Nicholas J Withers, Samuel M Moskowitz, Cori L Daines
No abstract text is available yet for this article.
September 24, 2020: American Journal of Respiratory and Critical Care Medicine
#6
Aprepitant For Cough in Lung Cancer: A Randomised Placebo-Controlled Trial and Mechanistic Insights.
Jaclyn A Smith, Amélie Harle, Rachel Dockry, Kimberley Holt, Philip Russell, Alex Molassiotis, Janelle Yorke, Ryan Robinson, Mark A Birrell, Maria G Belvisi, Fiona Blackhall
RATIONALE: Effective cough treatments are a significant unmet need in lung cancer patients. Aprepitant is a licensed treatment for nausea and vomiting, which blocks substance P activation of Neurokinin 1 (NK-1) receptors, a mechanism also implicated in cough. OBJECTIVE: To assess aprepitant in lung cancer patients with cough and evaluate mechanisms in vagal nerve tissue. METHODS: Randomised double-blind crossover trial of lung cancer patients with bothersome cough...
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
#7
Bartolome R Celli, Julie A Anderson, Nicholas J Cowans, Courtney Crim, Benjamin F Hartley, Fernando J Martinez, Andrea N Morris, Holly Quasny, Julie Yates, Jørgen Vestbo, Peter M A Calverley
BACKGROUND: Whether pharmacological therapy alters decline in forced expiratory volume in 1 second (FEV1) in chronic obstructive pulmonary disease (COPD) remains controversial. Because pharmacotherapy improves health status, exacerbation rate and symptoms, it is unethical to complete placebo-controlled long-term studies aimed at modifying FEV1 decline. OBJECTIVE: We conducted a systematic review of placebo-controlled pharmacological trials lasting ≥1 year to address the question of whether therapy alters FEV1 decline...
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
#8
Guillaume Geri, Jean-Christophe Richard
No abstract text is available yet for this article.
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
#9
Hongsheng Gui, Albert M Levin, Donglei Hu, Patrick Sleiman, Shujie Xiao, Angel Cy Mak, Mao Yang, Andrea J Barczak, Scott Huntsman, Celeste Eng, Samantha Hochstadt, Ellen Zhang, Kyle Whitehouse, Samantha Simons, Whitney Cabral, Sami Takriti, Gonçalo Abecasis, Thomas W Blackwell, Hyun Min Kang, Deborah A Nickerson, Soren Germer, David E Lanfear, Frank Gilliland, W James Gauderman, Rajesh Kumar, David J Erle, Fernando D Martinez, Hakon Hakonarson, Esteban G Burchard, L Keoki Williams
RATIONALE: The 17q12-21.1 locus is one of the most highly replicated genetic associations with asthma. Individuals of African descent have lower LD in this region, which could facilitate identifying causal variants. OBJECTIVE: To identify functional variants at 17q12-21.1 associated with early-onset asthma among African American individuals. METHODS AND MEASUREMENTS: We evaluated African American participants from the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) (n=1,940), the Study of African Americans, Asthma, Genes & Environment (SAGE II) (n=885), and Study of the Genetic Causes of Complex Pediatric Disorders - Asthma (GCPD-A) (n=2,805)...
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
#10
Jin Jun, Deena Kelly Costa
No abstract text is available yet for this article.
September 23, 2020: American Journal of Respiratory and Critical Care Medicine
#11
Annemijn H Jonkman, Myrte Wennen, Michael C Sklar, Chris de Korte, Pieter R Tuinman
No abstract text is available yet for this article.
September 22, 2020: American Journal of Respiratory and Critical Care Medicine
#12
Eleni Soilemezi, Savvoula Savvidou, Dimitrios Matamis
No abstract text is available yet for this article.
September 22, 2020: American Journal of Respiratory and Critical Care Medicine
#13
Ken-Ichiro Inoue, Tomoya Sagawa, Hirohisa Takano
No abstract text is available yet for this article.
September 21, 2020: American Journal of Respiratory and Critical Care Medicine
#14
Oliver J McElvaney, Natalie L McEvoy, Noel G McElvaney, Gerard F Curley
No abstract text is available yet for this article.
September 21, 2020: American Journal of Respiratory and Critical Care Medicine
#15
Mathieu Blot, Abderrahmane Bourredjem, Christine Binquet, Lionel Piroth
No abstract text is available yet for this article.
September 21, 2020: American Journal of Respiratory and Critical Care Medicine
#16
Stephanie LaBedz, Jerry A Krishnan
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
#17
Brian E Cade, Hassan S Dashti, Syed M Hassan, Susan Redline, Elizabeth W Karlson
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
#18
Roberto Tonelli, Ivana Castaniere, Riccardo Fantini, Luca Tabbì, Stefano Busani, Lara Pisani, Stefano Nava, Enrico Clini, Alessandro Marchioni
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
#19
Ajay Kumar Jha
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
#20
Elena Spinelli, Ines Marongiu, Tommaso Mauri
No abstract text is available yet for this article.
September 18, 2020: American Journal of Respiratory and Critical Care Medicine
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