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American Journal of Respiratory and Critical Care Medicine

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https://read.qxmd.com/read/30875247/long-term-azithromycin-reduces-haemophilus-influenzae-and-increases-antibiotic-resistance-in-severe-asthma
#1
Steven L Taylor, Lex E X Leong, Fredrick M Mobegi, Jocelyn M Choo, Steve Wesselingh, Ian A Yang, John W Upham, Paul N Reynolds, Sandra Hodge, Alan L James, Christine Jenkins, Matthew J Peters, Melissa Baraket, Guy B Marks, Peter G Gibson, Geraint B Rogers, Jodie L Simpson
Rationale The macrolide antibiotic, azithromycin, reduces exacerbations in adults with persistent symptomatic asthma. However, owing to the pleotropic properties of macrolides, unintended bacteriological consequences such as augmented pathogen colonization or dissemination of antibiotic-resistant organisms can occur, calling into question the long-term safety of azithromycin maintenance therapy. Objectives To assess the effects of azithromycin on the airway microbiota, pathogen abundance, and carriage of antibiotic-resistance genes...
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875244/changes-in-electrical-impedance-tomography-findings-of-icu-patients-during-rapid-infusion-of-a-fluid-bolus-a-prospective-observational-study
#2
Tobias Becher, Anna Wendler, Christine Eimer, Norbert Weiler, Inéz Frerichs
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875243/sustained-inflation-of-infant-lungs-from-bench-to-bedside-and-back-again
#3
Martin Keszler
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875238/could-adjunctive-pharmacology-mitigate-cardiovascular-consequences-of-osa
#4
Najib T Ayas, Glen E Foster, Neomi Shah, John Floras, Ismail Laher
Obstructive sleep apnea (OSA) is associated with adverse physiologic and biochemical sequelae including systemic inflammation, oxidative stress, increased chemoreceptor reflex activity, sympathetic nervous system activation, and endothelial dysfunction. In addition, compelling data strongly implicate OSA in the development of cardiovascular disease (CVD) including myocardial infarction and stroke. Yet in clinical trials, CPAP therapy alone did not reduce cardiovascular events in intention to treat analyses...
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875236/mid-term-reproducibility-of-chest-mri-in-adults-with-clinically-stable-cystic-fibrosis-and-chronic-obstructive-pulmonary-disease
#5
Mark O Wielpütz, Monika Eichinger, Sabine Wege, Ralf Eberhardt, Marcus A Mall, Hans-Ulrich Kauczor, Michael U Puderbach, Frank Risse, Claus P Heußel, Gudula Heußel
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30875233/shifting-landscape-of-airway-infection-in-early-cystic-fibrosis
#6
Jordana E Hoppe, Scott D Sagel
No abstract text is available yet for this article.
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30871339/short-term-exposure-to-ambient-air-pollution-and-asthma-mortality
#7
Yuewei Liu, Jingju Pan, Hai Zhang, Chunxiang Shi, Guo Li, Zhe Peng, Jixuan Ma, Yun Zhou, Lan Zhang
RATIONALE: Short-term exposure to air pollution has been associated with asthma exacerbation and increased health-care use due to asthma, but its effect on asthma mortality remains largely unknown. OBJECTIVES: To quantitatively assess the association between short-term exposure to air pollution and asthma mortality. METHODS: We investigated 4,454 individuals who lived in Hubei province, China and died from asthma between 2013 and 2018. A case-crossover design and conditional logistic regression models were applied for data analyses...
March 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30865834/small-but-mighty-prenatal-ufp-exposure-linked-to-childhood-asthma-incidence
#8
Rosalind J Wright, Brent A Coull
No abstract text is available yet for this article.
March 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30865833/chasing-the-holy-grail-modulating-neutrophils-in-inflammatory-lung-disease
#9
Charlotte Summers
No abstract text is available yet for this article.
March 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30864816/exposure-to-greater-air-pollution-when-traveling-abroad-is-associated-with-decreased-lung-function
#10
M J Ruzmyn Vilcassim, George D Thurston, Lung-Chi Chen, Chris C Lim, Terry Gordon
No abstract text is available yet for this article.
March 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30864813/poor-concordance-between-sequential-transbronchial-lung-cryobiopsy-and-surgical-lung-biopsy-in-the-diagnosis-of-diffuse-interstitial-lung-diseases
#11
Micaela Romagnoli, Thomas V Colby, Jean-Philippe Berthet, Anne Sophie Gamez, Jean-Pierre Mallet, Isabelle Serre, Alessandra Cancellieri, Alberto Cavazza, Laurence Solovei, Andrea Dell'Amore, Giampiero Dolci, Aldo Guerrieri, Paul Reynaud, Sébastien Bommart, Maurizio Zompatori, Giorgia Dalpiaz, Stefano Nava, Rocco Trisolini, Carey M Suehs, Isabelle Vachier, Nicolas Molinari, Arnaud Bourdin
Rationale The diagnostic concordance between transbronchial lung cryobiopsy (TBLC) -- versus surgical lung biopsy (SLB) as the current gold standard -- in interstitial lung disease (ILD) cases requiring histology remains controversial. Objectives To assess diagnostic concordance between TBLC and SLB sequentially performed in the same patients, the diagnostic yield of both techniques, and subsequent changes in multidisciplinary assessment (MDA) decisions. Methods A two-center prospective study included ILD patients with a non-definite usual interstitial pneumonia (UIP) pattern (on HRCT scan) confirmed at a first MDA...
March 13, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30860862/long-term-outcomes-after-prolonged-mechanical-ventilation-what-of-those-cast-away
#12
Anica C Law, Allan J Walkey
No abstract text is available yet for this article.
March 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30860861/recommended-reading-from-the-university-college-london-hospitals-pulmonary-medicine-fellows
#13
James P Allinson, James Brown, Kate Gibb, Neal Navani
No abstract text is available yet for this article.
March 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30860860/endobronchial-treatment-of-bronchial-atresia
#14
Ramy Masroujeh, Benjamin Young
No abstract text is available yet for this article.
March 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30860859/migrated-endovascular-coil-an-unwelcomed-guest
#15
Leonard Riley, Tiago Machuca, Hassan Alnuaimat, Ali Ataya
No abstract text is available yet for this article.
March 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30860857/cellular-senescence-as-a-mechanism-and-target-in-chronic-lung-diseases
#16
Peter J Barnes, Jonathan Baker, Louise E Donnelly
Cellular senescence is now considered an important driving mechanism for chronic lung diseases, particularly COPD and idiopathic pulmonary fibrosis. Cellular senescence is due to replicative and stress-related senescence with activation of p53 and p16INK4a respectively, leading to activation of p21CIP1 and cell cycle arrest. Senescent cells secrete multiple inflammatory proteins known as the senescence-associated secretory phenotype (SASP), leading to low grade chronic inflammation, which further drives senescence...
March 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30860856/reply-to-long-term-outcomes-after-prolonged-mechanical-ventilation-what-of-those-cast-away
#17
Amal Jubran, Brydon J B Grant, Martin J Tobin
No abstract text is available yet for this article.
March 12, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30849230/recommended-reading-from-the-thomas-jefferson-university-pulmonary-fellows
#18
Ena Gupta, Mitchell D Jacobs, Gautam George, Jesse Roman
No abstract text is available yet for this article.
March 8, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30849229/effect-of-cpap-on-blood-pressure-in-obstructive-sleep-apnea-with-cardiovascular-disease
#19
Emer Van Ryswyk, Craig S Anderson, Ferran Barbe, Kelly A Loffler, Geraldo Lorenzi-Filho, Yuanming Luo, Weiwei Quan, Jiguang Wang, Danni Zheng, R Doug McEvoy
No abstract text is available yet for this article.
March 8, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30849228/il4r%C3%AE-signaling-abrogates-hypoxic-neutrophil-survival-and-limits-acute-lung-injury-responses-in-vivo
#20
Alison J Harris, Ananda S Mirchandani, Ruairi W Lynch, Fiona Murphy, Liam Delaney, Donna Small, Patricia Coelho, Emily R Watts, Pranvera Sadiku, David Griffith, Rebecca S Dickinson, Eilidh Clark, Joseph A Willson, Tyler Morrison, Massimilliano Mazzone, Peter Carmeliet, Bart Ghesquiere, Cecilia O'Kane, Danny McAuley, Steve J Jenkins, Moira K B Whyte, Sarah R Walmsley
RATIONALE: Acute respiratory distress syndrome (ARDS) is defined by the presence of systemic hypoxia and consequent upon disordered neutrophilic inflammation. Local mechanisms limiting the duration and magnitude of this neutrophilic response remain poorly understood. OBJECTIVES: We aimed to test the hypothesis that during acute lung inflammation tissue production of pro-resolution type 2 cytokines (IL-4 and IL-13) dampen the pro-inflammatory effects of hypoxia through suppression of Hypoxia Inducible Factor (HIF-1)α-mediated neutrophil adaptation, resulting in resolution of the lung injury...
March 8, 2019: American Journal of Respiratory and Critical Care Medicine
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