Bhushan H Katira, Kohei Osada, Doreen Engelberts, Luca Bastia, L Felipe Damiani, Xuehan Li, Han Chen, Takeshi Yoshida, Marcelo B P Amato, Niall D Ferguson, Martin Post, Brian P Kavanagh, Laurent J Brochard
RATIONALE: The physiological basis of lung protection and the impact of PEEP during pronation in ARDS are not fully elucidated. OBJECTIVES: To compare pleural pressure (Ppl) gradient, ventilation distribution and regional compliance between dependent and non-dependent lung, and investigate the effect of PEEP during supination and pronation. METHODS: We used a 2-hit model of lung injury (saline lavage and high-volume ventilation) in 14 mechanically ventilated pigs and studied supine and prone position...
January 6, 2021: American Journal of Respiratory and Critical Care Medicine