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Ashley Mulchrone, Alessandro Bellofiore, Johannes M Douwes, Neal Duong, Arij G Beshish, Gregory P Barton, Christopher J Francois, Marlowe W Eldridge, Kara N Goss, Naomi C Chesler
No abstract text is available yet for this article.
November 7, 2019: American Journal of Respiratory and Critical Care Medicine
#2
Masahiro Narita, Jeanne Sullivan Meissner, Joseph Burzynski
No abstract text is available yet for this article.
November 7, 2019: American Journal of Respiratory and Critical Care Medicine
#3
Miranda Kirby, Naoya Tanabe, Dragoş M Vasilescu, Joel D Cooper, John E McDonough, Stijn E Verleden, Bart M Vanaudenaerde, Don D Sin, Wan C Tan, Harvey O Coxson, James C Hogg
No abstract text is available yet for this article.
November 7, 2019: American Journal of Respiratory and Critical Care Medicine
#4
Tracey L Bonfield
No abstract text is available yet for this article.
November 7, 2019: American Journal of Respiratory and Critical Care Medicine
#5
Yuewei Liu, Yun Zhou
No abstract text is available yet for this article.
November 6, 2019: American Journal of Respiratory and Critical Care Medicine
#6
Yueh-Ying Han, Erick Forno, Juan C Celedón
No abstract text is available yet for this article.
November 6, 2019: American Journal of Respiratory and Critical Care Medicine
#7
Nadine Al-Naamani, Corey E Ventetuolo
No abstract text is available yet for this article.
November 5, 2019: American Journal of Respiratory and Critical Care Medicine
#8
Domenico Luca Grieco, Luca S Menga, Valeria Raggi, Filippo Bongiovanni, Gian Marco Anzellotti, Eloisa S Tanzarella, Maria Grazia Bocci, Giovanna Mercurio, Antonio M Dell'Anna, Davide Eleuteri, Giuseppe Bello, Riccardo Maviglia, Giorgio Conti, Salvatore Maurizio Maggiore, Massimo Antonelli
RATIONALE: High-flow nasal cannula (HFNC) and helmet noninvasive ventilation (NIV) are used for the management of acute hypoxemic respiratory failure. OBJECTIVES: Physiological comparison of HFNC and helmet NIV in hypoxemic patients. MEASUREMENTS: Fifteen hypoxemic patients with PaO2/FiO2<200 mmHg received helmet NIV (PEEP≥10 cmH2O, pressure support=10-15 cmH2O) and HFNC (50 liters/minute) in randomized cross-over order. Arterial blood gases, dyspnea and comfort were recorded...
November 5, 2019: American Journal of Respiratory and Critical Care Medicine
#9
Erick Forno
No abstract text is available yet for this article.
November 4, 2019: American Journal of Respiratory and Critical Care Medicine
#10
Libing Yang, Daniel G Dunlap, Shulin Qin, Adam Fitch, Kelvin Li, Carl D Koch, Mehdi Nouraie, Rebecca DeSensi, Ken S Ho, Jeremy J Martinson, Barbara Methé, Alison Morris
RATIONALE: Mechanisms of HIV-associated chronic obstructive pulmonary disease (COPD) are poorly understood. The oral microbiome shapes the lung microbiome and gut dysbiosis can impact lung diseases; however, relationships of the oral and gut microbiome to COPD in HIV have not been explored. OBJECTIVES: To examine alterations in the oral and gut microbiome associated with pulmonary disease in persons with HIV (PWH). METHODS: 75 PWH and 93 HIV-uninfected men from the Multicenter AIDS cohort study performed pulmonary function testing...
November 4, 2019: American Journal of Respiratory and Critical Care Medicine
#11
Juan F Masa, Babak Mokhlesi, Iván Benítez, Maria Victoria Mogollon, Francisco Javier Gomez de Terreros, Maria Ángeles Sánchez-Quiroga, Auxiliadora Romero, Candela Caballero-Eraso, Maria Luz Alonso-Álvarez, Estrella Ordax-Carbajo, Teresa Gomez-Garcia, Mónica González, Soledad López-Martín, José M Marin, Sergi Martí, Trinidad Díaz-Cambriles, Eusebi Chiner, Carlos Egea, Javier Barca, Francisco-José Vázquez-Polo, Miguel A Negrín, María Martel-Escobar, Ferran Barbe, Jaime Corral
RATIONALE: Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomized trials have assessed the impact of long-term noninvasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. OBJECTIVES: We performed a pre-specified secondary analysis of the largest multicenter randomized controlled trial of obesity hypoventilation syndrome (Pickwick project, n=221 patient with OHS and coexistent severe obstructive sleep apnea) to determine the comparative effectiveness of 3 years of NIV and CPAP on structural and functional echocardiographic changes...
November 4, 2019: American Journal of Respiratory and Critical Care Medicine
#12
Francois Lellouche, Erwan L'Her
No abstract text is available yet for this article.
October 31, 2019: American Journal of Respiratory and Critical Care Medicine
#13
Hyperoxemia and Death of Critically Ill: Is There a Problem of Confounding by Indication or Outcome?
Robert C Tasker
No abstract text is available yet for this article.
October 31, 2019: American Journal of Respiratory and Critical Care Medicine
#14
Edward Palmer, Daniel Martin, Mervyn Singer, Steve Harris
No abstract text is available yet for this article.
October 31, 2019: American Journal of Respiratory and Critical Care Medicine
#15
John J Marini, Patricia R M Rocco, Luciano Gattinoni
Ventilation is inherently a dynamic process. The present-day clinical practice of concentrating on the static inflation characteristics of the individual tidal cycle (plateau pressure, PEEP and their difference [driving pressure, the ratio of tidal volume to compliance]) does not take into account key factors shown experimentally to influence ventilator-induced lung injury (VILI). These include rate of airway pressure change (influenced by flow amplitude, inspiratory time fraction, inspiratory inflation contour) and cycling frequency...
October 30, 2019: American Journal of Respiratory and Critical Care Medicine
#16
Jeremy S Brown
No abstract text is available yet for this article.
October 30, 2019: American Journal of Respiratory and Critical Care Medicine
#17
Daniel A Culver, Hyun Kim
No abstract text is available yet for this article.
October 30, 2019: American Journal of Respiratory and Critical Care Medicine
#18
Randall J Nett, John M Wood, David J Blackley
No abstract text is available yet for this article.
October 30, 2019: American Journal of Respiratory and Critical Care Medicine
#19
Joshua Hodgson, Emilia M Swietlik, Richard M Salmon, Charaka Hadinnapola, Ivana Nikolic, John Wharton, Jingxu Guo, James Liley, Matthias Haimel, Marta Bleda, Laura Southgate, Rajiv D Machado, Jennifer M Martin, Carmen M Treacy, Katherine Yates, Louise C Daugherty, Olga Shamardina, Deborah Whitehorn, Simon Holden, Harm J Bogaard, Colin Church, Gerry Coghlan, Robin Condliffe, Paul A Corris, Cesare Danesino, Mélanie Eyries, Henning Gall, Stefano Ghio, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, Barbara Girerd, Arjan C Houweling, Luke Howard, Marc Humbert, David G Kiely, Gabor Kovacs, Allan Lawrie, Robert V MacKenzie Ross, Shahin Moledina, David Montani, Andrea Olschewski, Horst Olschewski, Willem H Ouwehand, Andrew J Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J Rhodes, Laura Scelsi, Werner Seeger, Florent Soubrier, Jay Suntharalingam, Mark R Toshner, Richard C Trembath, Anton Vonk Noordegraaf, Stephen J Wort, Martin R Wilkins, Paul B Yu, Wei Li, Stefan Gräf, Paul D Upton, Nicholas W Morrell
OBJECTIVES: Recently, rare heterozygous mutations in GDF2 were identified in patients with pulmonary arterial hypertension (PAH). GDF2 encodes the circulating bone morphogenetic protein, BMP9, which is a ligand for the BMP type 2 receptor (BMPR2). Here we determine the functional impact of GDF2 mutations and characterised plasma BMP9 and BMP10 levels in patients with idiopathic PAH. METHODS: Missense BMP9 mutant proteins were expressed in vitro and the impact on BMP9 protein processing and secretion, endothelial signalling and functional activity was assessed...
October 29, 2019: American Journal of Respiratory and Critical Care Medicine
#20
Luciano Gattinoni, John John Marini, Michael Quintel
No abstract text is available yet for this article.
October 29, 2019: American Journal of Respiratory and Critical Care Medicine
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