Pei Chia Eng, Maria Phylactou, Ambreen Qayum, Casper Woods, Hayoung Lee, Sara Aziz, Benedict Moore, Alexander D Miras, Alexander N Comninos, Tricia Tan, Steve Franks, Waljit S Dhillo, Ali Abbara
Obesity-related hypogonadotropic hypogonadism is a well-characterized condition in men (termed male obesity-related secondary hypogonadism; MOSH), however, an equivalent condition has not been as clearly described in women. The prevalence of polycystic ovary syndrome (PCOS) is known to increase with obesity, but PCOS is more typically characterized by increased gonadotropin releasing hormone (GnRH) (and by proxy luteinizing hormone; LH) pulsatility, rather than by the reduced gonadotropin levels observed in MOSH...
August 10, 2023: Endocrine Reviews