Domenico Luca Grieco, Luca S Menga, Melania Cesarano, Tommaso Rosà, Savino Spadaro, Maria Maddalena Bitondo, Jonathan Montomoli, Giulia Falò, Tommaso Tonetti, Salvatore L Cutuli, Gabriele Pintaudi, Eloisa S Tanzarella, Edoardo Piervincenzi, Filippo Bongiovanni, Antonio M Dell'Anna, Luca Delle Cese, Cecilia Berardi, Simone Carelli, Maria Grazia Bocci, Luca Montini, Giuseppe Bello, Daniele Natalini, Gennaro De Pascale, Matteo Velardo, Carlo Alberto Volta, V Marco Ranieri, Giorgio Conti, Salvatore Maurizio Maggiore, Massimo Antonelli
Importance: High-flow nasal oxygen is recommended as initial treatment for acute hypoxemic respiratory failure and is widely applied in patients with COVID-19. Objective: To assess whether helmet noninvasive ventilation can increase the days free of respiratory support in patients with COVID-19 compared with high-flow nasal oxygen alone. Design, Setting, and Participants: Multicenter randomized clinical trial in 4 intensive care units (ICUs) in Italy between October and December 2020, end of follow-up February 11, 2021, including 109 patients with COVID-19 and moderate to severe hypoxemic respiratory failure (ratio of partial pressure of arterial oxygen to fraction of inspired oxygen ≤200)...
March 25, 2021: JAMA