Yonathan Freund, Damien Viglino, Marine Cachanado, Clémentine Cassard, Emmanuel Montassier, Bénedicte Douay, Jérémy Guenezan, Pierrick Le Borgne, Youri Yordanov, Armelle Severin, Mélanie Roussel, Matthieu Daniel, Adrien Marteau, Nicolas Peschanski, Dorian Teissandier, Richard Macrez, Julia Morere, Tahar Chouihed, Damien Roux, Frédéric Adnet, Ben Bloom, Anthony Chauvin, Tabassome Simon
IMPORTANCE: Tracheal intubation is recommended for coma patients and those with severe brain injury, but its use in patients with decreased levels of consciousness from acute poisoning is uncertain. OBJECTIVE: To determine the effect of intubation withholding vs routine practice on clinical outcomes of comatose patients with acute poisoning and a Glasgow Coma Scale score less than 9. DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter, randomized trial conducted in 20 emergency departments and 1 intensive care unit (ICU) that included comatose patients with suspected acute poisoning and a Glasgow Coma Scale score less than 9 in France between May 16, 2021, and April 12, 2023, and followed up until May 12, 2023...
November 29, 2023: JAMA