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https://read.qxmd.com/read/31097213/prophylactic-antibiotics-in-the-prevention-of-infection-after-operative-vaginal-delivery-anode-a-multicentre-randomised-controlled-trial
#1
Marian Knight, Virginia Chiocchia, Christopher Partlett, Oliver Rivero-Arias, Xinyang Hua, Kim Hinshaw, Derek Tuffnell, Louise Linsell, Edmund Juszczak
BACKGROUND: Risk factors for maternal infection are clearly recognised, including caesarean section and operative vaginal birth. Antibiotic prophylaxis at caesarean section is widely recommended because there is clear systematic review evidence that it reduces incidence of maternal infection. Current WHO guidelines do not recommend routine antibiotic prophylaxis for women undergoing operative vaginal birth because of insufficient evidence of effectiveness. We aimed to investigate whether antibiotic prophylaxis prevented maternal infection after operative vaginal birth...
May 13, 2019: Lancet
https://read.qxmd.com/read/31097212/antibiotics-for-operative-vaginal-delivery-practice-changing-data
#2
Vincenzo Berghella, Federica Bellussi
No abstract text is available yet for this article.
May 13, 2019: Lancet
https://read.qxmd.com/read/31079938/atezolizumab-plus-bevacizumab-versus-sunitinib-in-patients-with-previously-untreated-metastatic-renal-cell-carcinoma-immotion151-a-multicentre-open-label-phase-3-randomised-controlled-trial
#3
Brian I Rini, Thomas Powles, Michael B Atkins, Bernard Escudier, David F McDermott, Cristina Suarez, Sergio Bracarda, Walter M Stadler, Frede Donskov, Jae Lyun Lee, Robert Hawkins, Alain Ravaud, Boris Alekseev, Michael Staehler, Motohide Uemura, Ugo De Giorgi, Begoña Mellado, Camillo Porta, Bohuslav Melichar, Howard Gurney, Jens Bedke, Toni K Choueiri, Francis Parnis, Tarik Khaznadar, Alpa Thobhani, Shi Li, Elisabeth Piault-Louis, Gretchen Frantz, Mahrukh Huseni, Christina Schiff, Marjorie C Green, Robert J Motzer
BACKGROUND: A phase 2 trial showed improved progression-free survival for atezolizumab plus bevacizumab versus sunitinib in patients with metastatic renal cell carcinoma who express programmed death-ligand 1 (PD-L1). Here, we report results of IMmotion151, a phase 3 trial comparing atezolizumab plus bevacizumab versus sunitinib in first-line metastatic renal cell carcinoma. METHODS: In this multicentre, open-label, phase 3, randomised controlled trial, patients with a component of clear cell or sarcomatoid histology and who were previously untreated, were recruited from 152 academic medical centres and community oncology practices in 21 countries, mainly in Europe, North America, and the Asia-Pacific region, and were randomly assigned 1:1 to either atezolizumab 1200 mg plus bevacizumab 15 mg/kg intravenously once every 3 weeks or sunitinib 50 mg orally once daily for 4 weeks on, 2 weeks off...
May 9, 2019: Lancet
https://read.qxmd.com/read/31079937/durable-complete-response-in-renal-cell-carcinoma-clinical-trials
#4
Patrick G Pilié, Eric Jonasch
No abstract text is available yet for this article.
May 9, 2019: Lancet
https://read.qxmd.com/read/31076175/increases-in-alcohol-consumption-in-middle-income-countries-will-lead-to-increased-harms
#5
Sarah Callinan, Michael Livingston
No abstract text is available yet for this article.
May 7, 2019: Lancet
https://read.qxmd.com/read/31076174/global-alcohol-exposure-between-1990-and-2017-and-forecasts-until-2030-a-modelling-study
#6
Jakob Manthey, Kevin D Shield, Margaret Rylett, Omer S M Hasan, Charlotte Probst, Jürgen Rehm
BACKGROUND: Alcohol use is a leading risk factor for global disease burden, and data on alcohol exposure are crucial to evaluate progress in achieving global non-communicable disease goals. We present estimates on the main indicators of alcohol exposure for 189 countries from 1990-2017, with forecasts up to 2030. METHODS: Adult alcohol per-capita consumption (the consumption in L of pure alcohol per adult [≥15 years]) in a given year was based on country-validated data up to 2016...
May 7, 2019: Lancet
https://read.qxmd.com/read/31060799/trickle-down-innovation-and-the-longevity-of-nations
#7
Dhruv Khullar, Josephine Fisher, Amitabh Chandra
No abstract text is available yet for this article.
May 3, 2019: Lancet
https://read.qxmd.com/read/31056295/drug-eluting-or-bare-metal-stents-for-percutaneous-coronary-intervention-a-systematic-review-and-individual-patient-data-meta-analysis-of-randomised-clinical-trials
#8
Raffaele Piccolo, Kaare H Bonaa, Orestis Efthimiou, Olivier Varenne, Andrea Baldo, Philip Urban, Christoph Kaiser, Wouter Remkes, Lorenz Räber, Adam de Belder, Arnoud W J van 't Hof, Goran Stankovic, Pedro A Lemos, Tom Wilsgaard, Jörg Reifart, Alfredo E Rodriguez, Expedito E Ribeiro, Patrick W J C Serruys, Alex Abizaid, Manel Sabaté, Robert A Byrne, Jose M de la Torre Hernandez, William Wijns, Peter Jüni, Stephan Windecker, Marco Valgimigli
BACKGROUND: New-generation drug-eluting stents (DES) have mostly been investigated in head-to-head non-inferiority trials against early-generation DES and have typically shown similar efficacy and superior safety. How the safety profile of new-generation DES compares with that of bare-metal stents (BMS) is less clear. METHODS: We did an individual patient data meta-analysis of randomised clinical trials to compare outcomes after implantation of new-generation DES or BMS among patients undergoing percutaneous coronary intervention...
May 2, 2019: Lancet
https://read.qxmd.com/read/31056294/are-drug-eluting-stents-safer-than-bare-metal-stents
#9
Lisette Okkels Jensen, Evald Høj Christiansen
No abstract text is available yet for this article.
May 2, 2019: Lancet
https://read.qxmd.com/read/31056293/risk-of-hiv-transmission-through-condomless-sex-in-serodifferent-gay-couples-with-the-hiv-positive-partner-taking-suppressive-antiretroviral-therapy-partner-final-results-of-a-multicentre-prospective-observational-study
#10
Alison J Rodger, Valentina Cambiano, Tina Bruun, Pietro Vernazza, Simon Collins, Olaf Degen, Giulio Maria Corbelli, Vicente Estrada, Anna Maria Geretti, Apostolos Beloukas, Dorthe Raben, Pep Coll, Andrea Antinori, Nneka Nwokolo, Armin Rieger, Jan M Prins, Anders Blaxhult, Rainer Weber, Arne Van Eeden, Norbert H Brockmeyer, Amanda Clarke, Jorge Del Romero Guerrero, Francois Raffi, Johannes R Bogner, Gilles Wandeler, Jan Gerstoft, Felix Gutiérrez, Kees Brinkman, Maria Kitchen, Lars Ostergaard, Agathe Leon, Matti Ristola, Heiko Jessen, Hans-Jürgen Stellbrink, Andrew N Phillips, Jens Lundgren
BACKGROUND: The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared with the evidence available for transmission risk in heterosexual couples. The aim of the second phase of the PARTNER study (PARTNER2) was to provide precise estimates of transmission risk in gay serodifferent partnerships. METHODS: The PARTNER study was a prospective observational study done at 75 sites in 14 European countries...
May 2, 2019: Lancet
https://read.qxmd.com/read/31056292/gentamicin-as-an-alternative-treatment-for-gonorrhoea
#11
Robert D Kirkcaldy, Kimberly A Workowski
No abstract text is available yet for this article.
May 2, 2019: Lancet
https://read.qxmd.com/read/31056291/gentamicin-compared-with-ceftriaxone-for-the-treatment-of-gonorrhoea-g-tog-a-randomised-non-inferiority-trial
#12
Jonathan D C Ross, Clare Brittain, Michelle Cole, Claire Dewsnap, Jan Harding, Trish Hepburn, Louise Jackson, Matthew Keogh, Tessa Lawrence, Alan A Montgomery, Tracy E Roberts, Kirsty Sprange, Wei Tan, Sukhwinder Thandi, John White, Janet Wilson, Lelia Duley
BACKGROUND: Gonorrhoea is a common sexually transmitted infection for which ceftriaxone is the current first-line treatment, but antimicrobial resistance is emerging. The objective of this study was to assess the effectiveness of gentamicin as an alternative to ceftriaxone (both combined with azithromycin) for treatment of gonorrhoea. METHODS: G-ToG was a multicentre, parallel-group, pragmatic, randomised, non-inferiority trial comparing treatment with gentamicin to treatment with ceftriaxone for patients with gonorrhoea...
May 2, 2019: Lancet
https://read.qxmd.com/read/31056290/successful-treatment-of-hiv-eliminates-sexual-transmission
#13
Myron S Cohen
No abstract text is available yet for this article.
May 2, 2019: Lancet
https://read.qxmd.com/read/31047716/department-of-error
#14
(no author information available yet)
No abstract text is available yet for this article.
April 29, 2019: Lancet
https://read.qxmd.com/read/31043324/iran-in-transition
#15
REVIEW
Goodarz Danaei, Farshad Farzadfar, Roya Kelishadi, Arash Rashidian, Omid M Rouhani, Shirin Ahmadnia, Alireza Ahmadvand, Mandana Arabi, Ali Ardalan, Mohammad Arhami, Mohammad Hossein Azizi, Moslem Bahadori, Jill Baumgartner, Arash Beheshtian, Shirin Djalalinia, Leila Doshmangir, Ali Akbar Haghdoost, Rosa Haghshenas, Ahmad Reza Hosseinpoor, Farhad Islami, Farin Kamangar, Davood Khalili, Kaveh Madani, Hossein Masoumi-Asl, Ali Mazyaki, Ali Mirchi, Ehsan Moradi, Touraj Nayernouri, Debbie Niemeier, Amir-Houshang Omidvari, Niloofar Peykari, Farhad Pishgar, Mostafa Qorbani, Kazem Rahimi, Afarin Rahimi-Movaghar, Fahimeh Ramezani Tehrani, Nazila Rezaei, Saeid Shahraz, Amirhossein Takian, Ali Tootee, Majid Ezzati, Hamid Reza Jamshidi, Bagher Larijani, Reza Majdzadeh, Reza Malekzadeh
Being the second-largest country in the Middle East, Iran has a long history of civilisation during which several dynasties have been overthrown and established and health-related structures have been reorganised. Iran has had the replacement of traditional practices with modern medical treatments, emergence of multiple pioneer scientists and physicians with great contributions to the advancement of science, environmental and ecological changes in addition to large-scale natural disasters, epidemics of multiple communicable diseases, and the shift towards non-communicable diseases in recent decades...
April 26, 2019: Lancet
https://read.qxmd.com/read/31036338/peanut-oral-immunotherapy-balancing-benefits-and-risks-for-individuals
#16
Graham Roberts, Elizabeth Angier
No abstract text is available yet for this article.
April 26, 2019: Lancet
https://read.qxmd.com/read/31036337/effect-of-ultra-short-term-treatment-of-patients-with-iron-deficiency-or-anaemia-undergoing-cardiac-surgery-a-prospective-randomised-trial
#17
Donat R Spahn, Felix Schoenrath, Gabriela H Spahn, Burkhardt Seifert, Philipp Stein, Oliver M Theusinger, Alexander Kaserer, Inga Hegemann, Axel Hofmann, Francesco Maisano, Volkmar Falk
BACKGROUND: Anaemia and iron deficiency are frequent in patients scheduled for cardiac surgery. This study assessed whether immediate preoperative treatment could result in reduced perioperative red blood cell (RBC) transfusions and improved outcome. METHODS: In this single-centre, randomised, double-blind, parallel-group controlled study, patients undergoing elective cardiac surgery with anaemia (n=253; haemoglobin concentration (Hb) <120 g/L in women and Hb <130 g/L in men) or isolated iron deficiency (n=252; ferritin <100 mcg/L, no anaemia) were enrolled...
April 26, 2019: Lancet
https://read.qxmd.com/read/31036336/restrictive-strategy-versus-usual-care-for-cholecystectomy-in-patients-with-gallstones-and-abdominal-pain-secure-a-multicentre-randomised-parallel-arm-non-inferiority-trial
#18
Aafke H van Dijk, Sarah Z Wennmacker, Philip R de Reuver, Carmen S S Latenstein, Otmar Buyne, Sandra C Donkervoort, Quirijn A J Eijsbouts, Joos Heisterkamp, Klass H In Het Hof, Jan Janssen, Vincent B Nieuwenhuijs, Henk M Schaap, Pascal Steenvoorde, Hein B A C Stockmann, Djamila Boerma, Gert P Westert, Joost P H Drenth, Marcel G W Dijkgraaf, Marja A Boermeester, Cornelius J H M van Laarhoven
BACKGROUND: International guidelines advise laparoscopic cholecystectomy to treat symptomatic, uncomplicated gallstones. Usual care regarding cholecystectomy is associated with practice variation and persistent post-cholecystectomy pain in 10-41% of patients. We aimed to compare the non-inferiority of a restrictive strategy with stepwise selection with usual care to assess (in)efficient use of cholecystectomy. METHODS: We did a multicentre, randomised, parallel-arm, non-inferiority study in 24 academic and non-academic hospitals in the Netherlands...
April 26, 2019: Lancet
https://read.qxmd.com/read/31036335/pain-after-cholecystectomy-for-symptomatic-gallstones
#19
Rachel V Guest, Kjetil Søreide
No abstract text is available yet for this article.
April 26, 2019: Lancet
https://read.qxmd.com/read/31036334/the-2019-un-high-level-meeting-on-universal-health-coverage
#20
LETTER
Simon Wright, Refiloe Mabejane
No abstract text is available yet for this article.
April 26, 2019: Lancet
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