journal
https://read.qxmd.com/read/33493436/sos-brazil-science-under-attack
#1
LETTER
Pedro C Hallal
No abstract text is available yet for this article.
January 22, 2021: Lancet
https://read.qxmd.com/read/33493435/covid-19-and-the-moral-imagination
#2
Mahomed Said Patel, Christine Beatrice Phillips
No abstract text is available yet for this article.
January 22, 2021: Lancet
https://read.qxmd.com/read/33493434/classical-hodgkin-lymphoma
#3
REVIEW
Pauline Brice, Eric de Kerviler, Jonathan W Friedberg
Classical Hodgkin lymphoma is one of the more frequent lymphomas and is generally considered a highly curable disease with standard first-line chemotherapy and radiotherapy in some cases. Despite these outstanding results, major problems remain unresolved. First, there are still patients who will not be cured with front-line regimens and, second, many patients who are cured of classical Hodgkin lymphoma continue to die prematurely due to the late toxic effects of their therapy. Because the median age of patients with classical Hodgkin lymphoma is in the mid-30s, the disease's impact on the number of years lost from productive life is remarkable...
January 22, 2021: Lancet
https://read.qxmd.com/read/33485464/first-line-nivolumab-plus-ipilimumab-in-unresectable-malignant-pleural-mesothelioma-checkmate-743-a-multicentre-randomised-open-label-phase-3-trial
#4
Paul Baas, Arnaud Scherpereel, Anna K Nowak, Nobukazu Fujimoto, Solange Peters, Anne S Tsao, Aaron S Mansfield, Sanjay Popat, Thierry Jahan, Scott Antonia, Youssef Oulkhouir, Yolanda Bautista, Robin Cornelissen, Laurent Greillier, Francesco Grossi, Dariusz Kowalski, Jerónimo Rodríguez-Cid, Praveen Aanur, Abderrahim Oukessou, Christine Baudelet, Gérard Zalcman
BACKGROUND: Approved systemic treatments for malignant pleural mesothelioma (MPM) have been limited to chemotherapy regimens that have moderate survival benefit with poor outcomes. Nivolumab plus ipilimumab has shown clinical benefit in other tumour types, including first-line non-small-cell lung cancer. We hypothesised that this regimen would improve overall survival in MPM. METHODS: This open-label, randomised, phase 3 study (CheckMate 743) was run at 103 hospitals across 21 countries...
January 21, 2021: Lancet
https://read.qxmd.com/read/33485463/immune-checkpoint-inhibitors-in-mesothelioma-a-turning-point
#5
Giovanni Luca Ceresoli, Giulia Pasello
No abstract text is available yet for this article.
January 21, 2021: Lancet
https://read.qxmd.com/read/33485462/an-action-plan-for-pan-european-defence-against-new-sars-cov-2-variants
#6
LETTER
Viola Priesemann, Rudi Balling, Melanie M Brinkmann, Sandra Ciesek, Thomas Czypionka, Isabella Eckerle, Giulia Giordano, Claudia Hanson, Zdenek Hel, Pirta Hotulainen, Peter Klimek, Armin Nassehi, Andreas Peichl, Matjaz Perc, Elena Petelos, Barbara Prainsack, Ewa Szczurek
No abstract text is available yet for this article.
January 21, 2021: Lancet
https://read.qxmd.com/read/33485461/global-variation-in-postoperative-mortality-and-complications-after-cancer-surgery-a-multicentre-prospective-cohort-study-in-82-countries
#7
(no author information available yet)
BACKGROUND: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. METHODS: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia...
January 21, 2021: Lancet
https://read.qxmd.com/read/33484634/preparing-for-a-covid-19-resurgence-in-the-who-african-region
#8
LETTER
Benido Impouma, Franck Mboussou, Francis Kasolo, Zabulon Yoti, Matshidiso R Moeti
No abstract text is available yet for this article.
January 20, 2021: Lancet
https://read.qxmd.com/read/33484633/adrenal-insufficiency
#9
REVIEW
Eystein S Husebye, Simon H Pearce, Nils P Krone, Olle Kämpe
Adrenal insufficiency can arise from a primary adrenal disorder, secondary to adrenocorticotropic hormone deficiency, or by suppression of adrenocorticotropic hormone by exogenous glucocorticoid or opioid medications. Hallmark clinical features are unintentional weight loss, anorexia, postural hypotension, profound fatigue, muscle and abdominal pain, and hyponatraemia. Additionally, patients with primary adrenal insufficiency usually develop skin hyperpigmentation and crave salt. Diagnosis of adrenal insufficiency is usually delayed because the initial presentation is often non-specific; physician awareness must be improved to avoid adrenal crisis...
January 20, 2021: Lancet
https://read.qxmd.com/read/33460559/the-changing-treatment-landscape-in-haemophilia-from-standard-half-life-clotting-factor-concentrates-to-gene-editing
#10
REVIEW
Maria Elisa Mancuso, Johnny N Mahlangu, Steven W Pipe
Congenital haemophilia A (factor VIII deficiency) and B (factor IX deficiency) are X-linked bleeding disorders. Replacement therapy has been the cornerstone of the management of haemophilia, aiming to reduce the mortality and morbidity of chronic crippling arthropathy. Frequent intravenous injections are burdensome and costly for patients, consequently with poor adherence and restricted access to therapy for many patients worldwide. Bioengineered clotting factors with enhanced pharmacokinetic profiles can reduce the burden of treatment...
January 15, 2021: Lancet
https://read.qxmd.com/read/33453755/rochelle-walensky-new-director-of-the-us-cdc
#11
Susan Jaffe
No abstract text is available yet for this article.
January 14, 2021: Lancet
https://read.qxmd.com/read/33453149/the-european-medicines-agency-s-eu-conditional-marketing-authorisations-for-covid-19-vaccines
#12
Marco Cavaleri, Harald Enzmann, Sabine Straus, Emer Cooke
No abstract text is available yet for this article.
January 13, 2021: Lancet
https://read.qxmd.com/read/33428868/long-term-follow-up-of-recovered-patients-with-covid-19
#13
Monica Cortinovis, Norberto Perico, Giuseppe Remuzzi
No abstract text is available yet for this article.
January 8, 2021: Lancet
https://read.qxmd.com/read/33428867/6-month-consequences-of-covid-19-in-patients-discharged-from-hospital-a-cohort-study
#14
Chaolin Huang, Lixue Huang, Yeming Wang, Xia Li, Lili Ren, Xiaoying Gu, Liang Kang, Li Guo, Min Liu, Xing Zhou, Jianfeng Luo, Zhenghui Huang, Shengjin Tu, Yue Zhao, Li Chen, Decui Xu, Yanping Li, Caihong Li, Lu Peng, Yong Li, Wuxiang Xie, Dan Cui, Lianhan Shang, Guohui Fan, Jiuyang Xu, Geng Wang, Ying Wang, Jingchuan Zhong, Chen Wang, Jianwei Wang, Dingyu Zhang, Bin Cao
BACKGROUND: The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity. METHODS: We did an ambidirectional cohort study of patients with confirmed COVID-19 who had been discharged from Jin Yin-tan Hospital (Wuhan, China) between Jan 7, 2020, and May 29, 2020...
January 8, 2021: Lancet
https://read.qxmd.com/read/33422176/wakley-wu-lien-teh-prize-essay-2020-passing-the-baton-to-the-next-generation-of-health-workers
#15
Esther Lau, Helena Hui Wang, Jie Qiao, Baoguo Jiang, Richard Horton
No abstract text is available yet for this article.
January 7, 2021: Lancet
https://read.qxmd.com/read/33357496/novichok-nerve-agent-poisoning
#16
David Steindl, Wolfgang Boehmerle, Roland Körner, Damaris Praeger, Marcel Haug, Jens Nee, Adrian Schreiber, Franziska Scheibe, Katharina Demin, Philipp Jacoby, Rudolf Tauber, Sven Hartwig, Matthias Endres, Kai-Uwe Eckardt
No abstract text is available yet for this article.
December 22, 2020: Lancet
https://read.qxmd.com/read/33357495/organophosphorus-poisoning-the-wet-opioid-toxidrome
#17
Michael Eddleston, Fazle Rabbi Chowdhury
No abstract text is available yet for this article.
December 22, 2020: Lancet
https://read.qxmd.com/read/33357494/covid-19-and-the-swedish-enigma
#18
Mariam Claeson, Stefan Hanson
No abstract text is available yet for this article.
December 22, 2020: Lancet
https://read.qxmd.com/read/33357493/covid-19-vaccines-and-women-s-security
#19
Sophie Harman, Asha Herten-Crabb, Rosemary Morgan, Julia Smith, Clare Wenham
No abstract text is available yet for this article.
December 22, 2020: Lancet
https://read.qxmd.com/read/33357492/uk-covid-19-public-inquiry-needed-to-learn-lessons-and-save-lives
#20
Jo Goodman, Kathryn de Prudhoe, Charlie Williams
No abstract text is available yet for this article.
December 22, 2020: Lancet
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