journal
https://read.qxmd.com/read/34324214/postvaccinal-encephalitis-after-chadox1-ncov-19
#1
Frédéric Zuhorn, Tilmann Graf, Randolf Klingebiel, Wolf-Rüdiger Schäbitz, Andreas Rogalewski
The global SARS-CoV-2 pandemic has contributed to more than 163 million confirmed infections and 3.3 million deaths worldwide. The severity of the pandemic has led to an unprecedented effort to develop multiple effective vaccines. Due to excellent safety and efficacy data from clinical trials, several vaccines were approved. We report a case series of postvaccinal encephalitis in temporal correlation to vaccination with ChAdOx1 nCov-19. The diagnostic criteria for possible autoimmune encephalitis were fulfilled...
July 29, 2021: Annals of Neurology
https://read.qxmd.com/read/34322904/aducanumab-what-about-the-patient
#2
EDITORIAL
Ronald C Petersen
No abstract text is available yet for this article.
July 28, 2021: Annals of Neurology
https://read.qxmd.com/read/34309075/genetic-studies-of-parkinson-s-alzheimer-s-disease-in-latinos-hispanics-new-insights-challenges
#3
Eng-King Tan
No abstract text is available yet for this article.
July 26, 2021: Annals of Neurology
https://read.qxmd.com/read/34309066/metabolite-signature-of-alzheimer-s-disease-in-adults-with-down-syndrome
#4
Victor Montal, Isabel Barroeta, Alexandre Bejanin, Jordi Pegueroles, María Carmona-Iragui, Miren Altuna, Bessy Benejam, Laura Videla, Susana Fernández, Concepcion Padilla, Mateus Aranha, Florencia Iulita, Didac Vidal-Piñeiro, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Juan Fortea
OBJECTIVE: To examine the Alzheimer's Disease metabolite signature through magnetic resonance spectroscopy in adults with Down syndrome and its relation with Alzheimer's Disease biomarkers and cortical thickness. METHODS: We included 118 adults with Down syndrome from the Down Alzheimer Barcelona Imaging Initiative and 71 euploid healthy controls from the Sant Pau Initiative on Neurodegeneration cohort. We measured the levels of myo-inositol (a marker of neuroinflammation) and N-acetyl-aspartate (a marker of neuronal integrity) in the precuneus using magnetic resonance spectroscopy...
July 26, 2021: Annals of Neurology
https://read.qxmd.com/read/34291846/spontaneous-intracranial-hypotension-due-to-skull-base-csf-leak
#5
Wouter I Schievink, L Madison Michael, Marcel Maya, Paul Klimo, Lucas Elijovich
No abstract text is available yet for this article.
July 22, 2021: Annals of Neurology
https://read.qxmd.com/read/34288089/introducing-the-child-neurology-society-leadership-diversity-equity-and-inclusion-task-force-ldei
#6
EDITORIAL
Audrey C Brumback, Rujuta B Wilson, Erika F Augustine, Nancy E Bass, Alexander G Bassuk, Diana M Cejas, Renée A Shellhaas, Jonathan B Strober, Ann C Tilton, Phillip L Pearl
No abstract text is available yet for this article.
July 21, 2021: Annals of Neurology
https://read.qxmd.com/read/34288055/lewy-body-like-inclusions-in-human-midbrain-organoid-carrying-glucocerebrosidase-and-alpha-synuclein-mutations
#7
Junghyun Jo, Lin Yang, Hoang-Dai Tran, Weonjin Yu, Alfred Xuyang Sun, Ya Yin Chang, Byung Chul Jung, Seung-Jae Lee, Tzuen Yih Saw, Bin Xiao, Audrey Tze Ting Khoo, Lai-Ping Yaw, Jessica Jiaxin Xie, Hidayat Lokman, Wei-Yi Ong, Grace Gui Yin Lim, Kah-Leong Lim, Eng-King Tan, Huck-Hui Ng, H Shawn Je
OBJECTIVE: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells (hPSCs) carrying glucocerebrosidase gene (GBA1) and α-synuclein (SNCA) perturbations to investigate genotype-to-phenotype relationships in Parkinson's disease, with the particular aim of recapitulating α-syn and Lewy body-related pathologies and the process of neurodegeneration in the hMLO model. METHOD: We generated and characterized hMLOs from GBA1-/- and SNCA O/E isogenic embryonic stem cells (ESCs) and also generated Lewy body-like inclusions (LBLIs) in GBA1/SNCA dual perturbation hMLOs and conduritol-b-epoxide-treated SNCA triplication hMLOs...
July 20, 2021: Annals of Neurology
https://read.qxmd.com/read/34288049/post-ictal-psychosis-in-epilepsy-a-clinico-genetic-study
#8
Vera Braatz, Helena Martins Custodio, Costin Leu, Luigi Agro, Baihan Wang, Stella Calafato, Genevieve Rayner, Michael G Doyle, Christian Hengsbach, Francesca Bisulli, Yvonne G Weber, Antonio Gambardella, Norman Delanty, Gianpiero Cavalleri, Jacqueline Foong, Ingrid E Scheffer, Samuel F Berkovic, Elvira Bramon, Simona Balestrini, Sanjay M Sisodiya
OBJECTIVE: Psychoses affecting people with epilepsy increase disease burden and diminish quality of life. We characterised post-ictal psychosis, which comprises about one-quarter of epilepsy-related psychoses, and has unknown causation. METHODS: We conducted a case-control cohort study including patients diagnosed with post-ictal psychosis, confirmed by psychiatric assessment, with available data regarding epilepsy, treatment, psychiatric history, psychosis profile and outcomes...
July 20, 2021: Annals of Neurology
https://read.qxmd.com/read/34288031/subicular-caspase-1-contributes-to-pharmacoresistance-in-temporal-lobe-epilepsy
#9
Cenglin Xu, Shuo Zhang, Yiwei Gong, Jiazhen Nao, Yujia Shen, Bei Tan, Shuheng Xu, Sunliang Cui, Yeping Ruan, Shuang Wang, Yi Wang, Zhong Chen
OBJECTIVE: Unidentified mechanisms largely restrict the viability of effective therapies in pharmacoresistant epilepsy. Our previous study revealed that hyperactivity of the subiculum is crucial for the genesis of pharmacoresistance in temporal lobe epilepsy (TLE), but the underlying molecular mechanism is not clear. METHODS: Here, we examined the role of subicular caspase-1, a key neural pro-inflammatory enzyme, in pharmacoresistant TLE. RESULTS: We found that the expression of activated caspase-1 in the subiculum, but not the CA1, was upregulated in pharmacoresistant amygdaloid-kindled rats...
July 20, 2021: Annals of Neurology
https://read.qxmd.com/read/34288044/covid-19-vaccine-associated-cerebral-venous-thrombosis-in-germany
#10
Jörg B Schulz, Peter Berlit, Hans-Christoph Diener, Christian Gerloff, Andreas Greinacher, Christine Klein, Gabor C Petzold, Marco Piccininni, Sven Poli, Rainer Röhrig, Helmuth Steinmetz, Thomas Thiele, Tobias Kurth
OBJECTIVE: We aimed to estimate the incidence of cerebral sinus and venous thrombosis (CVT) within one month from first-dose administration and the frequency of vaccine-induced immune thrombotic thrombocytopenia (VITT) as the underlying mechanism after vaccination with BNT162b2, ChAdOx1, and mRNA-1273, in Germany. METHODS: A web-based questionnaire was e-mailed to all Departments of Neurology. We asked to report cases of CVT within one month of a COVID-19 vaccination...
July 19, 2021: Annals of Neurology
https://read.qxmd.com/read/34279044/genomic-insights-into-myasthenia-gravis-identify-distinct-immunological-mechanisms-in-early-and-late-onset-disease
#11
Lahiru Handunnetthi, Bogdan Knezevic, Silva Kasela, Katie L Burnham, Lili Milani, Sarosh R Irani, Hai Fang, Julian C Knight
OBJECTIVE: To identify disease relevant genes and explore underlying immunological mechanisms that contribute to early and late onset forms of myasthenia gravis. METHODS: We used a novel genomic methodology to integrate genome wide association study (GWAS) findings in myasthenia gravis with cell-type specific information such as gene expression patterns and promotor-enhancer interactions, in order to identify disease relevant genes. Subsequently, we conducted additional genomic investigations including an expression quantitative analysis of 313 healthy people to provide mechanistic insights...
July 19, 2021: Annals of Neurology
https://read.qxmd.com/read/34279043/longitudinal-changes-in-hippocampal-network-connectivity-in-alzheimer-s-disease
#12
Sophie Dautricourt, Robin de Flores, Brigitte Landeau, Géraldine Poisnel, Matthieu Vanhoutte, Nicolas Delcroix, Francis Eustache, Denis Vivien, Vincent de la Sayette, Gaël Chételat
OBJECTIVE: The hippocampus is connected to two distinct cortical brain networks, the posterior-medial and the anterior-temporal networks, involving different medial temporal lobe (MTL) subregions. The aim of this study was to assess the functional alterations of these two networks, their changes over time and links to cognition in Alzheimer's disease. METHODS: We assessed MTL connectivity in 53 amyloid-β positive patients with mild cognitive impairment and Alzheimer dementia and 68 healthy elderly controls, using resting-state functional magnetic resonance imaging, cross-sectionally and longitudinally...
July 19, 2021: Annals of Neurology
https://read.qxmd.com/read/34278596/medicare-should-not-cover-aducanumab-as-a-treatment-for-alzheimer-s-disease
#13
EDITORIAL
Nuriel Moghavem, Victor W Henderson, Michael D Greicius
No abstract text is available yet for this article.
July 19, 2021: Annals of Neurology
https://read.qxmd.com/read/34260105/retraction
#14
(no author information available yet)
No abstract text is available yet for this article.
July 14, 2021: Annals of Neurology
https://read.qxmd.com/read/34240440/genetics-of-cluster-headache-takes-a-leap
#15
Aarno Palotie
No abstract text is available yet for this article.
July 9, 2021: Annals of Neurology
https://read.qxmd.com/read/34236104/strengthened-through-diversity-a-blueprint-for-organizational-change
#16
Allison Willis, Lesli Skolarus, Roland Faigle, Uma Menon, Hannah Redwine, Amanda Brown, Elizabeth Felton, Adys Mendizabal, Avindra Nath, Frances Jensen, Justin C McArthur
No abstract text is available yet for this article.
July 7, 2021: Annals of Neurology
https://read.qxmd.com/read/34235776/neurology-grand-rounds-changing-gears-dbs-for-dopaminergic-desensitization-in-parkinson-s-disease
#17
Daniel Weiss, Jens Volkmann, Alfonso Fasano, Andrea Kühn, Paul Krack, Günther Deuschl
In Parkinson's disease, both motor and neuropsychiatric complications unfold as consequence of both incremental striatal dopaminergic denervation and intensifying long-term dopaminergic treatment. Together, this leads to 'dopaminergic sensitization' steadily increasing motor and behavioral responses to dopaminergic medication that result in the detrimental sequalae of long-term dopaminergic treatment. We review the clinical presentations of 'dopaminergic sensitization', including rebound off and dyskinesia in the motor domain, and neuropsychiatric fluctuations and behavioral addictions with impulse control disorders and dopamine dysregulation syndrome in the neuropsychiatric domain...
July 7, 2021: Annals of Neurology
https://read.qxmd.com/read/34231919/mri-correlates-of-multiple-sclerosis-immunopathological-patterns
#18
Imke Metz, Ralitza H Gavrilova, Stephen D Weigand, Josa M Frischer, Bogdan F Popescu, Yong Guo, Mareike Gloth, W Oliver Tobin, Nicholas L Zalewski, Hans Lassmann, Jan M Tillema, Bradley J Erickson, Joseph E Parisi, Stephanie Becker, Fatima B König, Wolfgang Brück, Claudia F Lucchinetti
OBJECTIVE: Histology reveals that early active multiple sclerosis lesions can be classified into three main inter-individually heterogeneous but intra-individually stable immunopathological patterns of active demyelination (patterns I-III). In pattern I and II, a T-cell- and macrophage-associated demyelination is suggested, with pattern II only showing signs of a humoral immune response. Pattern III is characterized by inflammatory lesions with an oligodendrocyte degeneration. Patterns suggest pathogenic heterogeneity, and we postulated that they have distinct MRI correlates that may serve as biomarkers...
July 7, 2021: Annals of Neurology
https://read.qxmd.com/read/34231918/impact-of-time-of-day-and-season-on-outcome-in-acute-ischemic-stroke
#19
LETTER
Yelson Alejandro Picón-Jaimes, Ivan David Lozada-Martínez, Tariq Janjua, Luis Rafael Moscote-Salazar
No abstract text is available yet for this article.
July 7, 2021: Annals of Neurology
https://read.qxmd.com/read/34231246/functional-neurological-disorders-covid-19-vaccination
#20
LETTER
Jing-Han Ng, K Ray Chaudhuri, Eng-King Tan
No abstract text is available yet for this article.
July 7, 2021: Annals of Neurology
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