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English Abstract
Journal Article
[Stimulating action of hematoporphyrin on motor coordination and resistance to fatigue in rats].
Archivio Per le Scienze Mediche 1977 October
The pharmacological activity of hematoporphyrin has been studied on two experimental models which are able to monitor the motor coordination in the rat, namely the natatory exhaustion and the Rota-Rod tests. A dose related effect of hematoporphyrin in increasing resistane to motor fatigue has been observed in the Rota-Rod between 2-8 mg/kg i.p. Higher doses of hematoporphyrin seem to be less effective (difasic effect). In both tests hematoporphyrin was able to potentiate the stimulating effect of d-amphetamine (6 mg/kg s.c.). The potentiation appeared to be dose related between 2 and 8 mg/kg in the Rota Rod and between 2 and 16 mg/kg in the natatory test.
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