journal
https://read.qxmd.com/read/38606630/treatment-of-post-treatment-lyme-disease-symptoms-a-systematic-review
#1
JOURNAL ARTICLE
Rick Dersch, Gabriel Torbahn, Sebastian Rauer
BACKGROUND AND PURPOSE: Residual symptoms after treatment of Lyme disease, sometimes called post-treatment Lyme disease symptoms (PTLDs), are a matter of ongoing controversy. To guide treatment recommendations, a systematic review was performed of the available literature on specific treatment for PTLDs. METHODS: A systematic literature search of MEDLINE and CENTRAL was performed. No restrictions on case definitions, study types or specific interventions were applied to enable a comprehensive overview of the available literature...
April 12, 2024: European Journal of Neurology
https://read.qxmd.com/read/38597136/acquired-cerebral-amyloid-angiopathy-more-questions-than-answers
#2
EDITORIAL
Simon Fandler-Höfler, Benedetta Storti
No abstract text is available yet for this article.
April 10, 2024: European Journal of Neurology
https://read.qxmd.com/read/38588211/lower-serum-uric-acid-to-serum-creatinine-ratio-as-a-predictor-of-poor-functional-outcome-after-mechanical-thrombectomy-in-acute-ischaemic-stroke
#3
JOURNAL ARTICLE
Jinghan Xu, Xin Jiang, Qian Liu, Jiaxin Liu, Jinghuan Fang, Li He
BACKGROUND AND PURPOSE: The ratio of serum uric acid (SUA) to serum creatinine (SCr), representing normalized SUA for renal function, is associated with functional outcome in acute ischaemic stroke (AIS) patients. However, its effect on AIS patients undergoing mechanical thrombectomy (MT) remains unknown. This study aimed to investigate the influence of the SUA/SCr ratio on clinical outcome in MT-treated AIS patients. METHODS: Acute ischaemic stroke patients who underwent MT were continuously enrolled from January 2018 to June 2023...
April 8, 2024: European Journal of Neurology
https://read.qxmd.com/read/38587143/real-life-effectiveness-1-year-after-switching-to-avalglucosidase-alfa-in-late-onset-pompe-disease-patients-worsening-on-alglucosidase-alfa-therapy-a-french-cohort-study
#4
JOURNAL ARTICLE
Céline Tard, Françoise Bouhour, Maud Michaud, Stephane Beltran, Maxime Fournier, Florence Demurger, Emmeline Lagrange, Sylvain Nollet, Sabrina Sacconi, Jean-Baptiste Noury, Armelle Magot, Pascal Cintas, Dimitri Renard, Joëlle Deibener-Kaminsky, Claire Lefeuvre, Jean-Baptiste Davion, Emmanuelle Salort-Campana, Azzeddine Arrassi, Nadjib Taouagh, Marco Spinazzi, Shahram Attarian, Pascal Laforêt
INTRODUCTION: Late-onset Pompe disease (LOPD) is characterized by a progressive myopathy resulting from a deficiency of acid α-glucosidase enzyme activity. Enzyme replacement therapy has been shown to be effective, but long-term treatment results vary. Avalglucosidase alfa demonstrated non-inferiority to alglucosidase alfa in a phase 3 study, allowing in France compassionate access for advanced LOPD patients unresponsive to alglucosidase alfa. METHODS: Data from the French Pompe registry were analyzed for patients who benefited from a switch to avalglucosidase alfa with at least 1 year of follow-up...
April 8, 2024: European Journal of Neurology
https://read.qxmd.com/read/38576261/management-of-seizures-in-patients-with-primary-mitochondrial-diseases-consensus-statement-from-the-intererns-mitochondrial-working-group
#5
JOURNAL ARTICLE
Michelangelo Mancuso, Maria T Papadopoulou, Yi Shiau Ng, Anna Ardissone, Marcello Bellusci, Enrico Bertini, Lidia Di Vito, Teresinha Evangelista, Carmen Fons, Omar Hikmat, Rita Horvath, Thomas Klopstock, Cornelia Kornblum, Costanza Lamperti, Laura Licchetta, Maria Judit Molnar, Kristin N Varhaug, Mar O'Callaghan, Ronit M Pressler, Manuel Schiff, Serenella Servidei, Nora Szabo, Gráinne S Gorman, J Helen Cross, Shamima Rahman
BACKGROUND AND PURPOSE: Primary mitochondrial diseases (PMDs) are common inborn errors of energy metabolism, with an estimated prevalence of one in 4300. These disorders typically affect tissues with high energy requirements, including heart, muscle and brain. Epilepsy may be the presenting feature of PMD, can be difficult to treat and often represents a poor prognostic feature. The aim of this study was to develop guidelines and consensus recommendations on safe medication use and seizure management in mitochondrial epilepsy...
April 4, 2024: European Journal of Neurology
https://read.qxmd.com/read/38567516/real-world-persistence-of-multiple-sclerosis-disease-modifying-therapies
#6
JOURNAL ARTICLE
Emma C Tallantyre, Ruth Dobson, Joseph L J Froud, Frederika A St John, Valerie M Anderson, Tarunya Arun, Lauren Buckley, Nikos Evangelou, Helen L Ford, Ian Galea, Sumi George, Orla M Gray, Aimee M Hibbert, Mo Hu, Stella E Hughes, Gillian Ingram, Seema Kalra, Chia-Hui E Lim, Joela T M Mathews, Gavin V McDonnell, Naomi Mescall, Sam Norris, Stephen J Ramsay, Claire M Rice, Melanie J Russell, Marianne J Shawe-Taylor, Thomas E Williams, Katharine E Harding, Neil P Robertson
BACKGROUND AND PURPOSE: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real-world rates of persistence on disease-modifying therapies (DMTs) for people with multiple sclerosis (pwMS) and reasons for DMT discontinuation. METHODS: Treatment data on 4366 consecutive people with relapse-onset multiple sclerosis (MS) were pooled from 13 UK specialist centres during 2021...
April 3, 2024: European Journal of Neurology
https://read.qxmd.com/read/38567499/women-with-epilepsy-in-rwanda-a-real-real-world-study
#7
EDITORIAL
Bernhard J Steinhoff
No abstract text is available yet for this article.
April 3, 2024: European Journal of Neurology
https://read.qxmd.com/read/38563189/association-of-diabetes-mellitus-with-dementia-and-non-dementia-related-mortality-amongst-women-a-secondary-competing-risks-analysis-of-the-california-teachers-study
#8
JOURNAL ARTICLE
Cathleen Morgan, Bradon Annegers, Matthew K Taylor, Sara Shuger Fox, Tyler J Titcomb
BACKGROUND AND PURPOSE: The prevalence of dementia is rapidly increasing. Attempts to further understand modifiable risk factors such as diabetes mellitus (DM) are urgently needed to inform public health policies for prevention. Thus, the objective of the current study was to assess the relationship between DM and risk of dementia and non-dementia mortality amongst women in the California Teachers Study prospective cohort. METHODS: Women (n = 124,509) aged 22-104 years at baseline were included...
April 2, 2024: European Journal of Neurology
https://read.qxmd.com/read/38556899/beyond-t-cell-toxicity-intrathecal-chemokine-c-x-c-motif-ligand-indicating-b-cell-involvement-in-immune-related-adverse-events-following-checkpoint-inhibition-a-two-case-series-and-literature-review
#9
Ferdinand Otto, Michael Seiberl, Bieler Lara, Tobias Moser, Waltraud Kleindienst, Wallner-Essl Walter, Koelblinger Peter, Peter Wipfler, Andrea Harrer
BACKGROUND AND PURPOSE: This study was undertaken to raise awareness of a role of B cells in immune checkpoint inhibitor (ICI)-associated neurological immune-related adverse events (nirAE). METHODS: A systematic literature review was made, with case observations of a melanoma and a non-small cell lung cancer (NSCLC) patient who developed ICI-associated nirAE with cerebrospinal fluid (CSF) findings indicating B cell involvement. RESULTS: Two patients receiving ipilimumab/nivolumab for melanoma and chemotherapy/pembrolizumab for NSCLC developed nirAE in the form of myocarditis/myositis/myasthenia gravis overlap syndrome (triple M) and cerebellitis plus longitudinal transverse myelitis (c-LETM), respectively...
March 31, 2024: European Journal of Neurology
https://read.qxmd.com/read/38556893/functional-abilities-respiratory-and-cardiac-function-in-a-large-cohort-of-adults-with-duchenne-muscular-dystrophy-treated-with-glucocorticoids
#10
JOURNAL ARTICLE
Marianela Schiava, Robert Muni Lofra, John P Bourke, Jordi Díaz-Manera, Meredith K James, Maha A Elseed, Monika Malinova, Jassi Michel-Sodhi, Dionne Moat, Elisabetta Ghimenton, Michelle Mccallum, Carla Florencia Bolaño Díaz, Anna Mayhew, Karen Wong, Mark Richardson, Giorgio Tasca, Gail Eglon, Michelle Eagle, Cathy Turner, Emma Heslop, Volker Straub, Chiara Marini Bettolo, Michela Guglieri
BACKGROUND AND PURPOSE: The transition to adult services, and subsequent glucocorticoid management, is critical in adults with Duchenne muscular dystrophy. This study aims (1) to describe treatment, functional abilities, respiratory and cardiac status during transition to adulthood and adult stages; and (2) to explore the association between glucocorticoid treatment after loss of ambulation (LOA) and late-stage clinical outcomes. METHODS: This was a retrospective single-centre study on individuals with Duchenne muscular dystrophy (≥16 years old) between 1986 and 2022...
March 31, 2024: European Journal of Neurology
https://read.qxmd.com/read/38556758/antiganglioside-antibody-frequency-in-routine-clinical-care-settings
#11
JOURNAL ARTICLE
Niklas Giesche, Samuel Tobias Böhm-Gonzalez, Benedict Kleiser, Markus C Kowarik, Evelyn Dubois, Elke Stransky, Marcel Armbruster, Alexander Grimm, Justus Marquetand
BACKGROUND AND PURPOSE: Antiganglioside antibodies (AGAs) might be involved in the etiopathogenesis of many neurological diseases, such as Miller-Fisher syndrome (MFS) and Guillain-Barré syndrome (GBS). Available comprehensive reference data regarding AGA positivity rates and cross-responsiveness among AGAs (where one line immunoblot is positive for ≥1 AGA) during routine clinical care are scant. METHODS: In this 10-year monocentric retrospective study, 3560 immunoglobulin (Ig) G and IgM line blots (GA Generic Assays' Anti-Ganglioside Dot kit) obtained using cerebrospinal fluid (CSF) and serum samples from 1342 patients were analyzed for AGA positivity in terms of 14 diagnosis categories and AGA cross-responsiveness...
March 31, 2024: European Journal of Neurology
https://read.qxmd.com/read/38553933/service-delivery-in-acute-ischemic-stroke-patients-does-sex-matter
#12
JOURNAL ARTICLE
Friedrich Medlin, Davide Strambo, Dimitris Lambrou, Valeria Caso, Patrik Michel
BACKGROUND AND PURPOSE: Women with acute ischemic stroke (AIS) are older and have greater preexisting handicap than men. Given that these factors do not fully explain their poorer long-term outcomes, we sought to investigate potential sex differences in the delivery of acute stroke care in a large cohort of consecutive AIS patients. METHODS: We analyzed all patients from ASTRAL (Acute Stroke Registry and Analysis of Lausanne) from March 2003 to December 2019. Multivariable analyses were performed on acute time metrics, revascularization therapies, ancillary examinations for stroke workup, subacute symptomatic carotid artery revascularization, frequency of change in goals of care (palliative care), and length of hospital stay...
March 30, 2024: European Journal of Neurology
https://read.qxmd.com/read/38549186/therapeutic-choices-and-disease-activity-after-2%C3%A2-years-of-treatment-with-cladribine-an-italian-multicenter-study-cladstop
#13
JOURNAL ARTICLE
Irene Schiavetti, Alessio Signori, Angela Albanese, Jessica Frau, Eleonora Cocco, Lorena Lorefice, Sonia di Lemme, Roberta Fantozzi, Diego Centonze, Doriana Landi, Girolama Marfia, Elisabetta Signoriello, Giacomo Lus, Chiara Zecca, Claudio Gobbi, Rosa Iodice, Leonardo Malimpensa, Cinzia Cordioli, Diana Ferraro, Francesca Ruscica, Livia Pasquali, Anna Repice, Paolo Immovilli, Maria Teresa Ferrò, Simona Bonavita, Massimiliano Di Filippo, Gianmarco Abbadessa, Flora Govone, Maria Pia Sormani
BACKGROUND AND PURPOSE: Cladribine tablets, a purine analogue antimetabolite, offer a unique treatment regimen, involving short courses at the start of the first and second year, with no further treatment needed in years 3 and 4. However, comprehensive evidence regarding patient outcomes beyond the initial 24 months of cladribine treatment is limited. METHODS: This retrospective, multicenter study enrolled 204 patients with multiple sclerosis who had completed the 2-year course of cladribine treatment...
March 28, 2024: European Journal of Neurology
https://read.qxmd.com/read/38545838/general-neurology-current-challenges-and-future-implications
#14
JOURNAL ARTICLE
Claudio Lino Alberto Bassetti, Alice Accorroni, Astri Arnesen, Hamidon Bin Basri, Thomas Berger, Peter Berlit, Paul Boon, Augustina Charway-Felli, Jera Kruja, Steven Lewis, Michael Markowski, Marco Tulio Medina, Pamela McCombe, Elena Moro, Serefnur Ozturk, Paul Smith, Vladimira Vuletic
BACKGROUND AND PURPOSE: In the coming decades, the world will face an increasing burden of neurological disorders (ND) and an urgent need to promote brain health. These challenges contrast with an insufficient neurological workforce in most countries, as well as decreasing numbers of general neurologists and neurologists attracted to work in general neurology (GN). This white paper aims to review the current situation of GN and reflect on its future. METHODS: The European Academy of Neurology (EAN) task force (TF) met nine times between November 2021 and June 2023...
March 28, 2024: European Journal of Neurology
https://read.qxmd.com/read/38532638/factors-affecting-the-topography-of-nitrous-oxide-induced-neurological-complications
#15
JOURNAL ARTICLE
Eva Sole Cruz, Etienne Fortanier, Frederic Hilezian, Adil Maarouf, Clémence Boutière, Sarah Demortière, Audrey Rico, Emilien Delmont, Jean Pelletier, Shahram Attarian, Bertrand Audoin
BACKGROUND: The factors underlying the topography of nitrous oxide (N2 O)-induced neurological complications are unknown. METHODS: We included all consecutive patients admitted to the university hospital of Marseille for N2 O-induced neurological complications in a prospective observational study. Patients underwent neurological examination, spinal cord magnetic resonance imaging, and nerve conduction studies within the first 4 weeks after admission. RESULTS: In total, 61 patients were included: 45% with myeloneuropathy, 34% with isolated myelopathy, and 21% with isolated neuropathy...
March 26, 2024: European Journal of Neurology
https://read.qxmd.com/read/38532299/pre-morbid-sleep-disturbance-and-its-association-with-stroke-severity-results-from-the-international-interstroke-study
#16
JOURNAL ARTICLE
Christine E Mc Carthy, Salim Yusuf, Conor Judge, John Ferguson, Graeme J Hankey, Shahram Oveis Gharan, Albertino Damasceno, Helle Klingenberg Iversen, Annika Rosengren, Okechukwu Ogah, Luísa Avezum, Patricio Lopez-Jaramillo, Denis Xavier, Xingyu Wang, Sumathy Rangarajan, Martin J O'Donnell
BACKGROUND AND PURPOSE: Whilst sleep disturbances are associated with stroke, their association with stroke severity is less certain. In the INTERSTROKE study, the association of pre-morbid sleep disturbance with stroke severity and functional outcome following stroke was evaluated. METHODS: INTERSTROKE is an international case-control study of first acute stroke. This analysis included cases who completed a standardized questionnaire concerning nine symptoms of sleep disturbance (sleep onset latency, duration, quality, nocturnal awakening, napping duration, whether a nap was planned, snoring, snorting and breathing cessation) in the month prior to stroke (n = 2361)...
March 26, 2024: European Journal of Neurology
https://read.qxmd.com/read/38523419/expert-consensus-recommendations-for-improving-and-standardising-the-assessment-of-patients-with-generalised-myasthenia-gravis
#17
JOURNAL ARTICLE
Andreas Meisel, Francesco Saccà, Jennifer Spillane, John Vissing
BACKGROUND: Regular and consistent disease assessment could provide a clearer picture of burden in generalised myasthenia gravis (gMG) and improve patient care; however, the use of assessment tools in practice lacks standardisation. This modified Delphi approach was taken to review current evidence on assessment tool use in gMG and develop expert-derived consensus recommendations for good practice. METHODS: A European expert panel of 15 experienced gMG neurologists contributed to development of this consensus, four of whom formed a lead Sub-committee...
March 24, 2024: European Journal of Neurology
https://read.qxmd.com/read/38520186/compassionate-mind-training-for-people-with-parkinson-s-disease-a-pilot-study-and-predictors-of-response
#18
JOURNAL ARTICLE
Silvia Della Morte, Elena Berti, Carolina Lalli, Nicola Modugno, Francesca Morgante, Anette Schrag, Elena Makovac, Lucia Ricciardi
INTRODUCTION: People with Parkinson's disease (PD) often present with disabling neuropsychiatric symptoms. Compassionate mind training (CMT) is a psychological approach effective in reducing stress and promoting psychological well-being. Heart rate variability (HRV), a measure reflecting sympathovagal balance, has been associated with psychological well-being and a compassionate attitude. AIM: To assess the feasibility and effectiveness of CMT in enhancing the quality of life and psychological well-being in PD patients...
March 23, 2024: European Journal of Neurology
https://read.qxmd.com/read/38511878/rate-and-characteristics-of-inflammatory-neuropathies-associated-with-brentuximab-vedotin-therapy
#19
JOURNAL ARTICLE
Arthur Matthys, Benjamin Bardel, Fabien Le Bras, Alain Créange, Tarik Nordine, Romain Gounot, Saskia Ingen-Housz-Oro, Muriel Carvalho, Jean-Pascal Lefaucheur, Corinne Haioun, Violaine Planté-Bordeneuve, Thierry Gendre
BACKGROUND AND PURPOSE: Peripheral neuropathy is a frequent complication of brentuximab vedotin (BV), used in CD30+ lymphoma treatment. Classic BV-induced neuropathy (BV-CN) is a mild distal sensory axonal polyneuropathy. Severe BV-induced inflammatory neuropathies (BV-IN) have been described. BV-IN contribute to lymphoma-associated morbidity but might be immunotherapy-responsive. Our primary objective was to evaluate the rate of BV-IN. Our secondary objectives were to determine risk factors and warning signs...
March 21, 2024: European Journal of Neurology
https://read.qxmd.com/read/38511868/iatrogenic-cerebral-amyloid-angiopathy-in-older-adults
#20
JOURNAL ARTICLE
Larysa Panteleienko, Dermot Mallon, Rupert Oliver, Ahmed Toosy, Yuki Hoshino, Aya Murakami, Kanishk Kaushik, Marieke J H Wermer, Hideo Hara, Yusuke Yakushiji, Gargi Banerjee, David J Werring
BACKGROUND AND PURPOSE: An increasing number of cases of iatrogenic cerebral amyloid angiopathy (CAA) have now been reported worldwide. Proposed diagnostic criteria require a history of medical intervention with potential for amyloid-β transmission, for example those using cadaveric dura mater or requiring instrumentation of the brain or spinal cord. Clinical presentation occurs after an appropriate latency (usually three or four decades); to date, most patients with iatrogenic CAA have had 'early-onset' disease (compared to sporadic, age-related, CAA), as a consequence of childhood procedures...
March 21, 2024: European Journal of Neurology
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