journal
https://read.qxmd.com/read/38377687/the-intermediary-between-the-brain-and-the-immune-system-is-likely-to-be-the-thyroid
#1
JOURNAL ARTICLE
Leonidas Duntas
NA.
February 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38377675/epidemiology-prognosis-and-challenges-in-the-management-of-hyperthyroidism-related-atrial-fibrillation
#2
JOURNAL ARTICLE
Georgios Kostopoulos, Grigoris Effraimidis
Atrial fibrillation (AF) is a common condition with a global estimated prevalence of 60 million cases, and the most common cardiac complication of hyperthyroidism, occurring in 5-15% of overtly hyperthyroid patients. Additionally, subclinical hyperthyroidism and high-normal free T4 have been associated with an increased risk in the development of AF. Hyperthyroidism-related AF is a reversible cause of AF and the majority of patients spontaneously revert to sinus rhythm in 4-6 months during or after restoration of euthyroidism...
February 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38367342/hyperthyroidism-and-the-risk-of-non-thyroid-cancer-a-danish-register-based-long-term-follow-up-study
#3
JOURNAL ARTICLE
Thea Riis, Steen Joop Bonnema, Thomas Heiberg Brix, Lars Folkestad
OBJECTIVES: Cancer is the second most common cause of death worldwide. It is currently debated whether thyroid dysfunction is a modifiable cancer risk factor. Our aim was to evaluate the risk of cancer in patients with hyperthyroidism. METHODS: This is a register-based nationwide cohort study of individuals with a diagnosis of hyperthyroidism. Each hyperthyroid case was matched with four reference individuals according to age and sex. Using Fine and Gray competing risk regression models, we studied the association of hyperthyroidism and subsequent all-cause cancer diagnoses, adjusted for preexisting morbidity...
February 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38330593/hypothyroxinaemia-during-gestation-is-associated-with-low-ferritin-and-increased-levels-of-inflammatory-markers
#4
JOURNAL ARTICLE
Victor J M Pop, Johannes G Krabbe, Maarten Broeren, Wilmar Wiersinga, Margaret P Rayman
Objective Pregnancy is a state of inflammation facilitating implantation. Early isolated hypothyroxinaemia (IH) and increased inflammation (including obesity) have been associated with obstetric complications. The current study evaluated the association between IH, low ferritin and inflammation parameters (interleukin-6 (IL-6), C-reactive protein (CRP), human chorionic gonadotrophin (hCG) and obesity. Moreover, the course of these parameters throughout pregnancy was evaluated in relation to IH. Methods In the cross-sectional study (A) at 12 weeks, 2759 women participated and 2433 participated in the longitudinal study (B) with assessments at 12, 20 and 28 weeks gestation...
February 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38320401/the-eta-ese-statement-on-the-european-chemicals-agency-opinion-on-iodine-as-an-endocrine-disruptor
#5
JOURNAL ARTICLE
Rodrigo Moreno-Reyes, Ulla Feldt-Rasmussen, Agnieszka Piekiełko-Witkowska, Adriana Gaspar da Rocha, Corin Badiu, Josef Koehrle, Leonidas Duntas
In 2022, the European Chemicals Agency (ECHA) made a statement concluding that iodine is an endocrine disruptor (ED). "We stress the fact that the ECHA opinion ECHA/BPC/357/2022 is based on their misguidedly zooming in on exclusively the biocidal products (e.g., hand disinfectants, disinfection of animals' teats/udder, embalming fluids before cremation, etc.) that contain molecular iodine (I2), entirely neglecting [see the 2013 ECHA Regulation (EU) n°528/2012 describing iodine as being of "great importance for human health"...
February 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38290216/the-two-year-prognosis-of-multinodular-goiter-following-radiofrequency-ablation-based-on-all-nodule-burdens
#6
JOURNAL ARTICLE
Rui Guo, Bowen Zheng, Tao Wu, Yufan Lian, Tinghui Yin, Yuting He, Jingya Qin, Zhicheng Yao, Wen Xu, Jie Ren
OBJECTIVE: Few studies used all nodule burdens to specify the prognosis of multinodular goiter (MNG) following radiofrequency ablation (RFA), so this study addresses this question for MNG after completely ablating dominant nodules. METHODS: The RFA indications for MNG included a total of 2-5 benign nodules with over 50% normal tissue on ultrasound, 1-3 well-defined benign dominant nodules on cytology, largest diameter ≥20 mm and/or with clinical complaints, and patient refusal or unable of surgery...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38290210/serum-antim%C3%A3-llerian-hormone-is-lower-in-patients-with-multiple-radioiodine-dose-for-treatment-of-pediatric-thyroid-cancer
#7
JOURNAL ARTICLE
Marise Codeco de Andrade Barreto, Natalia Treistman, Lara Bessa Campelo Pinheiro Cavalcante, Daniel Alves Bulzico, Fernanda Accioly Andrade, Rossana Corbo, Paulo Alonso Garcia Alves, Fernanda Vaisman
INTRODUCTION: Treatment of patients with pediatric thyroid cancer (DTC) often involves radioiodine (RAI), which is associated with increased risks of short and long-term adverse outcomes. The impact of RAI treatment on the female reproductive system remains uncertain. Antimüllerian hormone (AMH) is a marker of ovarian reserve and is related to fertility. OBJECTIVE: To analyze the association between RAI and serum AHM level in women treated with RAI Methods: We evaluated women with pediatric DTC treated with RAI at the age of ≤19 years...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38271814/the-hypothalamic-pituitary-thyroid-axis-is-intact-in-male-insulin-receptor-substrate-4-knockout-mice
#8
JOURNAL ARTICLE
Emilie Brûlé, Xiang Zhou, Ying Wang, Evan R S Buddle, Luisina Ongaro, Mary Loka, Anita Boelen, Daniel Bernard
OBJECTIVE: Loss of function mutations in the insulin receptor substrate 4 (IRS4) gene cause a rare form of X-linked congenital central hypothyroidism in boys and men. Affected individuals show decreased thyroid-stimulation hormone (TSH) secretion. Members of the IRS family canonically act as scaffold proteins between tyrosine kinase receptors and downstream effectors. How loss of IRS4 affects TSH synthesis or secretion is unresolved. We therefore assessed IRS4's role in the hypothalamic-pituitary-thyroid axis of Irs4 knockout mice...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38241789/review-of-the-priodac-project-on-thyroid-protection-from-radioactive-iodine-by-repeated-iodine-intake-in-individuals-aged-12
#9
REVIEW
Jean-Charles Martin, Thierry Pourcher, Guillaume Phan, Julien Guglielmi, Caroline Crambes, François Caire-Maurisier, Dalila Lebsir, David Cohen, Clément Rosique, Lun Jing, Maha Hichri, Lisa Salleron, Jacques Darcourt, Maamar Souidi, Marc Benderitter
BACKGROUND: Intake of potassium iodide (KI) reduces the accumulation of radioactive iodine in the thyroid gland in the event of possible contamination by radioactive iodine released from a nuclear facility. The WHO has stated the need for research for optimal timing, appropriate dosing regimen and safety for repetitive iodine thyroid blocking (ITB). The French PRIODAC project, addressed all these issues, involving prolonged or repeated releases of radioactive iodine. Preclinical studies established an effective dose through pharmacokinetic modeling, demonstrating the safety of repetitive KI treatment without toxicity...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38236745/next-generation-sequencing-on-fine-needle-aspirates-in-neck-recurrence-of-thyroid-cancers
#10
JOURNAL ARTICLE
Helene Theodon, Erell Guillerm, Johanna Wassermann, Gabrielle Deniziaut, Loic Jaffrelot, Jérôme Alexandre Denis, Nathalie Chereau, Claude Bigorgne, Wiame Potonnier, Florence Coulet, Laurence Leenhardt, Camille Buffet
OBJECTIVES: Tumor molecular genotyping plays a key role in improving the management of advanced thyroid cancers. Molecular tests are classically performed on Formalin-Fixed Paraffin-Embedded (FFPE) carcinoma tissue. However alternative molecular testing strategies are needed when FFPE tumoral tissue is unavailable. The objective of our study was to retrospectively assess the performance of targeted DNA and RNA-based Next Generation Sequencing (NGS) on the fine needle aspirate from thyroid cancer cervical recurrences to determine if this strategy is efficient in clinical practice...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38236726/predicting-glucocorticoid-effectiveness-in-thyroid-eye-disease-combined-value-from-serological-lipid-metabolism-and-orbital-mri-parameter
#11
JOURNAL ARTICLE
Haitao Zhang, Hao Hu, Yueyue Wang, Xinjie Duan, Lu Chen, Jiang Zhou, Wen Chen, Weizhong Zhang, Xiaoquan Xu, Huanhuan Chen
PURPOSE: To determine the combined value of serological lipid metabolism and an orbital magnetic resonance imaging (MRI) quantitative parameter in predicting the effectiveness of glucocorticoid (GC) therapy in patients with thyroid eye disease (TED). METHODS: This study retrospectively enrolled 46 patients with active and moderate-to-severe TED (GC-effective group, n = 29; GC-ineffective group, n = 17). Serological lipid metabolism, the orbital MRI-based minimum signal intensity ratio of extraocular muscles (EOM-SIRmin) as well as other clinical parameters before GC therapy were collected and compared between the two groups...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38215286/selenium-supplementation-and-placebo-are-equally-effective-in-improving-quality-of-life-in-patients-with-hypothyroidism
#12
JOURNAL ARTICLE
Camilla Larsen, Kristian Hillert Winther, Per Karkov Cramon, Åse Krogh Rasmussen, Ulla Feldt-Rasmusssen, Nils Jakob Knudsen, Jakob Bue Bjorner, Lutz Schomburg, Kamil Demircan, Thilo Samson Chillon, Jeppe Gram, Stinus Gadegaard Hansen, Frans Brandt, Birte Nygaard, Torquil Watt, Laszlo Hegedus, Steen Joop Bonnema
PURPOSE: We investigated whether selenium supplementation improves quality-of-life (QoL) in patients with autoimmune thyroiditis (ID:NCT02013479). METHODS: We included 412 patients ≥18 years with serum thyroid peroxidase antibody (TPOAb) level ≥100 IU/mL in a multicentre double-blinded randomised clinical trial. The patients were allocated 1:1 to daily supplementation with either 200 μg selenium as selenium-enriched yeast or matching placebo tablets for 12 months, as add-on to levothyroxine (LT4) treatment...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38215285/psychiatric-complications-in-graves-disease
#13
JOURNAL ARTICLE
Mats Holmberg, Helge Malmgren, Peter Berglund, Birgitta Johansson, Helena Filipsson Nyström
BACKGROUND: Mood disorders are common in Graves' disease despite treatment. The pathogenic mechanisms involved are unknown and so is whether previous psychiatric disease influences these symptoms. METHODS: This is a longitudinal study conducted in Sweden, on 65 women with newly diagnosed Graves' disease and 65 matched controls. Participants were examined during hyperthyroidism and after 15 months of treatment. Examinations included blood sampling, and psychiatric testing with the Comprehensive Psychopathological Rating Scale for Affective Syndromes and the Structured Clinical Interview for DSM-IV-Axis I Disorders...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38198295/the-diagnostic-utility-of-repeat-fine-needle-aspirations-of-benign-thyroid-nodules
#14
JOURNAL ARTICLE
Rachelle Mendoza, Richard Cody Simon, Nicole A Cipriani, Tatjana Antic
Objective This study aims to analyze the diagnostic utility of multiple repeat FNA on thyroid nodules with initially benign diagnosis. Methods In a 5-year period, 1658 thyroid nodules with initially benign FNAs were retrospectively reviewed and followed for subsequent resection and repeat biopsy. Results Out of 2150 thyroid nodules, 1658 (77.1%) were diagnosed as benign on FNAs. The average age was 57.4 years (range 11-93 years), and most were females (83.8%). Repeat FNA was performed on 183 benign nodules, of which 141 (8...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38189657/real-world-clinical-profile-ret-mutation-testing-treatments-and-pros-for-mtc-in-europe
#15
JOURNAL ARTICLE
Grace Segall, Ravinder Singh, Min-Hua Jen, Isaac Sanderson, Alex Rider, Katie Lewis, Urpo Kiiskinen
OBJECTIVE: This study aimed to describe real-world patient and physician characteristics, rearranged during transfection (RET) mutation testing and results, treatment patterns, and patient-reported outcomes (PROs) in advanced or metastatic medullary thyroid cancer (aMTC) across five populous European countries. METHODS: Cross-sectional physician and patient surveys were used to collect quantitative and qualitative data in France, Germany, Italy, Spain, and the UK from July to December 2020, prior to the introduction of selective RET inhibitors in Europe...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38189656/association-of-sensitivity-to-thyroid-hormones-with-all-cause-mortality-in-euthyroid-us-adults-a-nationwide-cohort-study
#16
JOURNAL ARTICLE
Genfeng Yu, Siyang Liu, Cheng Song, Qintao Ma, Xingying Chen, Yuqi Jiang, Hualin Duan, Yajun He, Dongmei Wang, Heng Wan, Jie Shen
Background This study aimed to examine the associations of thyroid hormone sensitivity indices, including free triiodothyronine to free thyroxine (FT3/FT4) ratio, thyroid feedback quantile-based index by FT4 (TFQIFT4), thyroid-stimulating hormone index (TSHI), and thyrotrophic thyroxine resistance index (TT4RI) with all-cause mortality in euthyroid adults. Methods The study included 6243 euthyroid adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. FT3/FT4 ratio, TFQIFT4, TSHI, and TT4RI were calculated...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38181007/combinatorial-hypofractionated-radiotherapy-and-pembrolizumab-in-anaplastic-thyroid-cancer
#17
JOURNAL ARTICLE
Janice Ser Huey Tan, Timothy Kwang Yong Tay, Enya Hui Wen Ong, Michael Fehlings, Daniel Shao-Weng Tan, Nadiah Binte Sukma, Eileen Xueqin Chen, Jen-Hwei Sng, Connie Siew Poh Yip, Kok Hing Lim, Darren Wan-Teck Lim, Narayanan Gopalakrishna Iyer, Jacqueline Siok Gek Hwang, Melvin Lee Kiang Chua, Mei-Kim Ang
Objectives Anaplastic thyroid cancer (ATC) is an aggressive disease associated with poor outcomes and resistance to therapies. Our study aim was to evaluate the activity of a combinatorial regimen of sandwich sequencing of pembrolizumab immunotherapy and hypofractionated radiotherapy (RT). Methods In this case series, patients with ATC received hypofractionated RT (QUAD-shot) and intravenous pembrolizumab 200mg every 3-4 weeks. Pembrolizumab was continued until disease progression or up till 24 months. Concurrent Lenvatinib treatment was allowed...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38181005/the-diagnostic-value-of-gica-used-for-intraoperative-lymph-node-fna-tg-measurement-to-evaluate-thyroid-cancer-metastases
#18
JOURNAL ARTICLE
Shaodong Hou, Yiceng Sun, Zeyu Yang, Mi Tang, Tingjie Yin, Cong Shao, Cunye Yan, Linlong Mo, Yuquan Yuan, Supeng Yin, Fan Zhang
OBJECTIVE: It is crucial to diagnose lymph node (LN) metastases (LNM) before or during thyroid carcinoma surgery. Measurement of thyroglobulin (Tg) in fine-needle aspirate washout (FNA-Tg) is useful to assist in the diagnosis of LNM for papillary thyroid carcinoma (PTC). This study aimed to assess the diagnostic performance of a new technique based on a colloidal gold-based immunochromatographic assay (GICA) for intraoperative FNA-Tg in diagnosing LNM. METHODS: This prospective study enrolled 51 PTC patients who underwent cervical LN dissection...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38096102/real-world-practice-patterns-and-outcomes-for-rai-refractory-differentiated-thyroid-cancer
#19
JOURNAL ARTICLE
Andrew G Gianoukakis, Jennifer H Choe, Daniel W Bowles, Marcia S Brose, Lori Wirth, Taofeek Owonikoko, Svetlana Babajanyan, Francis P Worden
BACKGROUND: The optimal timing for initiating multi-kinase inhibitors (MKIs) in patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC) remains unclear. Thus, we evaluated the real-world practice patterns and outcomes in asymptomatic patients with progressive RAI-R DTC (≥1 lesion ≥1 cm in diameter) in the United States (US) and outside the US (non-US). METHODS: In this prospective, non-interventional, open-label study, eligible patients were chosen by treating physicians to receive MKI therapy (Cohort 1) or undergo active surveillance (Cohort 2) at study entry...
December 1, 2023: European Thyroid Journal
https://read.qxmd.com/read/38052158/activation-of-mitogen-activated-protein-kinase-signaling-and-development-of-papillary-thyroid-carcinoma-in-thyroid-stimulating-hormone-receptor-d633h-knockin-mice
#20
JOURNAL ARTICLE
Markus Eszlinger, Alexandra Stephenson, Shideh Mirhadi, Konrad Patyra, Michael F Moran, Moosa Khalil, Jukka Kero, Ralf Paschke
OBJECTIVE: Nonautoimmune hyperthyroidism (NAH) is rare and occurs due to a constitutively activating thyroid stimulating hormone receptor (TSHR) mutation. In contrast to other thyroid nodules, no further evaluation for malignancy is recommended for hot thyroid nodules. In the first model for NAH in mice nearly all homozygous mice had developed papillary thyroid cancer by 12 months of age. METHODS: To further evaluate these mice, whole exome sequencing and phosphoproteome analysis were employed in a further generation of mice to identify any other mutations potentially responsible and to identify the pathways involved in thyroid carcinoma development...
December 1, 2023: European Thyroid Journal
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