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ESC Heart Failure

Judith Zeller, Carolin Krüger, Valeria Lamounier-Zepter, Sabine Sag, Christina Strack, Margareta Mohr, Thomas Loew, Gerd Schmitz, Lars Maier, Marcus Fischer, Andrea Baessler
AIMS: Left ventricular diastolic dysfunction (LVDD) is common in obese subjects, and a relationship between epicardial adipose tissue (EAT), increased adipocytokines, and cardiovascular diseases has been reported. This study sought to examine as to whether the adipo-fibrokine activin A is a link between increased EAT, the metabolic syndrome (MetS), and LVDD in severely obese subjects. METHODS AND RESULTS: In 236 obese subjects (ø body mass index 39.8 ± 7.9 kg/m2 ) with a variable degree of the MetS and in 60 healthy non-obese controls (ø body mass index 24...
February 6, 2019: ESC Heart Failure
Isao Nishi, Yoshihiro Seo, Yoshie Hamada-Harimura, Masayoshi Yamamoto, Tomoko Ishizu, Akinori Sugano, Kimi Sato, Seika Sai, Kenichi Obara, Shoji Suzuki, Akira Koike, Kazutaka Aonuma, Masaki Ieda
AIMS: The objective of the study was to evaluate whether the geriatric nutritional risk index (GNRI) at discharge may be helpful in predicting the long-term prognosis of patients hospitalized with heart failure (HF) with preserved ejection fraction (HFpEF, left ventricular ejection fraction ≥50%), a common HF phenotype in the elderly. METHODS AND RESULTS: Overall, 110 elderly HFpEF patients (≥65 years) from the Ibaraki Cardiovascular Assessment Study-HF (n = 838) were enrolled...
February 1, 2019: ESC Heart Failure
Alejandro Martin-Malo, Gerrit Borchard, Beat Flühmann, Claudio Mori, Donald Silverberg, Ewa A Jankowska
Iron deficiency is the leading cause of anaemia and is highly prevalent in patients with chronic heart failure (CHF). Iron deficiency, with or without anaemia, can be corrected with intravenous (i.v.) iron therapy. In heart failure patients, iron status screening, diagnosis, and treatment of iron deficiency with ferric carboxymaltose are recommended by the 2016 European Society of Cardiology guidelines, based on results of two randomized controlled trials in CHF patients with iron deficiency. All i.v. iron complexes consist of a polynuclear Fe(III)-oxyhydroxide/oxide core that is stabilized with a compound-specific carbohydrate, which strongly influences their physico-chemical properties (e...
January 29, 2019: ESC Heart Failure
Akihiko Hodatsu, Noboru Fujino, Yuki Uyama, Osamu Tsukamoto, Atsuko Imai-Okazaki, Satoru Yamazaki, Osamu Seguchi, Tetsuo Konno, Kenshi Hayashi, Masa-Aki Kawashiri, Yoshihiro Asano, Masafumi Kitakaze, Seiji Takashima, Masakazu Yamagishi
AIMS: Cardiac myosin light chain kinase (cMLCK) phosphorylates ventricular myosin regulatory light chain 2 (MLC2v) and regulates sarcomere and cardiomyocyte organization. However, few data exist regarding the relationship between cMLCK mutations and MLC2v phosphorylation, particularly in terms of developing familial dilated cardiomyopathy (DCM) in whom cMLCK gene mutations were identified. The purpose of the present study was to investigate functional consequences of cMLCK mutations in DCM patients...
January 28, 2019: ESC Heart Failure
Hani N Sabbah, Ramesh C Gupta, Vinita Singh-Gupta, Kefei Zhang
AIMS: Elamipretide (ELAM), an aromatic-cationic tetrapeptide, interacts with cardiolipin and normalizes dysfunctional mitochondria of cardiomyocytes. This study examined the effects of ELAM on skeletal muscle mitochondria function in dogs with chronic heart failure (HF). METHODS AND RESULTS: Studies were performed in skeletal muscle biopsy specimens obtained from normal dogs (n = 7) and dogs with chronic intracoronary microembolization-induced HF (n = 14) treated with subcutaneous ELAM 0...
January 28, 2019: ESC Heart Failure
Akiomi Yoshihisa, Tetsuro Yokokawa, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Yasuchika Takeishi
AIMS: It has been reported that circulating soluble neprilysin (sNEP), which catalyses the degradation of several vasodilator peptides such as natriuretic peptides, predicts prognosis in heart failure patients with reduced ejection fraction. Hypoxia-induced decrease in NEP expression in lungs has been reported. However, the associations between sNEP and haemodynamic parameters, as well as the prognostic impact of sNEP in pulmonary hypertension (PH), remain unclear. We aimed to clarify the relationships between sNEP and natriuretic peptide, haemodynamics (e...
January 25, 2019: ESC Heart Failure
Zhiqing He, Jiamei Wang, Yihong Chen, Xiaoliang Cong, Na Li, Ru Ding, Anna Hultgårdh-Nilsson, Chun Liang
No abstract text is available yet for this article.
January 23, 2019: ESC Heart Failure
Santiago Roura, Francesc Rudilla, Paloma Gastelurrutia, Emma Enrich, Eva Campos, Josep Lupón, Evelyn Santiago-Vacas, Sergi Querol, Antoni Bayés-Genís
AIMS: Cell therapy can be used to repair functionally impaired organs and tissues in humans. Although autologous cells have an immunological advantage, it is difficult to obtain high cell numbers for therapy. Well-characterized banks of cells with human leukocyte antigens (HLA) that are representative of a given population are thus needed. The present study investigates the HLA allele and haplotype frequencies in a cohort of heart failure (HF) patients. METHODS AND RESULTS: We carried out the HLA typing and the allele and haplotype frequency analysis in 247 ambulatory HF patients...
January 23, 2019: ESC Heart Failure
Alessandro Capucci, Luca Santini, Stefano Favale, Domenico Pecora, Barbara Petracci, Leonardo Calò, Giulio Molon, Laura Cipolletta, Valter Bianchi, Valentina Schirripa, Vincenzo E Santobuono, Carmelo La Greca, Monica Campari, Sergio Valsecchi, Fabrizio Ammirati, Antonio D'Onofrio
AIMS: In the Multisensor Chronic Evaluation in Ambulatory Heart Failure Patients study, a novel algorithm for heart failure (HF) monitoring was implemented. The HeartLogic (Boston Scientific) index combines data from multiple implantable cardioverter defibrillator (ICD)-based sensors and has proved to be a sensitive and timely predictor of impending HF decompensation. The remote monitoring of HF patients by means of HeartLogic has never been described in clinical practice. We report post-implantation data collected from sensors, the combined index, and their association with clinical events during follow-up in a group of patients who received a HeartLogic-enabled device in clinical practice...
January 11, 2019: ESC Heart Failure
Cecilia Linde, Lei Qin, Ameet Bakhai, Hans Furuland, Marc Evans, Daniel Ayoubkhani, Eirini Palaka, Hayley Bennett, Phil McEwan
AIMS: At present, the clinical burden of hypokalaemia and hyperkalaemia among European heart failure patients, and relationships between serum potassium and adverse clinical outcomes in this population, is not well characterized. The aim of this study was to investigate associations between mortality, major adverse cardiac events, and renin-angiotensin-aldosterone system inhibitor (RAASi) discontinuation across serum potassium levels, in a UK cohort of incident heart failure patients...
January 10, 2019: ESC Heart Failure
Masahiro Kitamura, Kazuhiro P Izawa, Masakazu Yaekura, Yumi Mimura, Hitomi Nagashima, Koichiro Oka
AIMS: This study aims to examine the effect of differences in nutritional status on activities of daily living (ADL) and mobility recovery of hospitalized elderly patients with heart failure (HF). METHODS AND RESULTS: From among 377 consecutive HF patients who underwent rehabilitation at one acute-care hospital from January 2013 to August 2015, those who were aged ≥ 65 years could walk with assistance before hospitalization and who were hospitalized for the first time were included in this retrospective cohort study...
January 9, 2019: ESC Heart Failure
Jacek Stępniewski, Urszula Florczyk-Soluch, Krzysztof Szade, Karolina Bukowska-Strakova, Justyna Czapla, Sybilla Matuszczak, Magdalena Jarosz-Biej, Agnieszka Langrzyk, Mateusz Tomczyk, Izabela Rumieńczyk, Maria Kulecka, Michał Mikuła, Jerzy Ostrowski, Agnieszka Jaźwa-Kusior, Marian Zembala, Alicja Józkowicz, Michał Oskar Zembala, Józef Dulak
AIMS: Mesenchymal stromal cells isolated from different tissues are claimed to demonstrate similar therapeutic potential and are often incorrectly named mesenchymal stem cells. However, through comparison of such cells is lacking. This study aimed to compare the transcriptome of mesenchymal cells of the same phenotype isolated from the heart muscle and epicardial fat of the same patient, before and after culture. METHODS AND RESULTS: Cells were isolated from biopsies of the right ventricle and epicardial fat collected from five patients (three men and two women, mean age 59...
January 9, 2019: ESC Heart Failure
Hirotake Okazaki, Akihiro Shirakabe, Masato Matsushita, Yusaku Shibata, Tomofumi Sawatani, Saori Uchiyama, Kennichi Tani, Takayo Murase, Takashi Nakamura, Tsutomu Takayasu, Miwako Asano, Nobuaki Kobayashi, Noritake Hata, Kuniya Asai, Wataru Shimizu
AIMS: Plasma xanthine oxidoreductase (XOR) activity during the acute phase of acute heart failure (AHF) requires further elucidation. METHODS AND RESULTS: One hundred eighteen AHF patients and 231 control patients who attended a cardiovascular outpatient clinic were prospectively analysed. Blood samples were collected within 15 min of admission from AHF patients (AHF group) and control patients who visited a daily cardiovascular outpatient clinic (control group)...
January 8, 2019: ESC Heart Failure
Michael Lichtenauer, Tristan Pichler, Sarah Eder, Moritz Mirna, Theresa Magnes, Bernhard Wernly, Vera Paar, Christian Jung, Erika Prinz, Rainald Seitelberger, Uta C Hoppe
Herein, we report the case of a 67-year-old woman who was admitted to our hospital because of dyspnoea and oedema of the lower extremities. Transthoracic echocardiography revealed severe tricuspid and mitral regurgitation, and the leaflets of the tricuspid valve were found to be rigid and almost immobile. The plasma concentrations of serotonin and chromogranin A were elevated, and hence, suspicion for carcinoid heart disease was raised. In addition to the diagnostic workup and medical and surgical treatment, we analysed levels of novel cardiovascular biomarkers throughout the entire follow-up by means of enzyme-linked immunosorbent assay...
January 8, 2019: ESC Heart Failure
Miguel Gouveia, Raquel Ascenção, Francesca Fiorentino, João Costa, Daniel Caldeira, Paula Broeiro-Gonçalves, Candida Fonseca, Margarida Borges
AIMS: Heart failure (HF) is a clinical syndrome with significant social and economic burden. We aimed to estimate the burden of HF in mainland Portugal over a 22-year time horizon, between 2014 and 2036. METHODS AND RESULTS: Heart failure burden was measured in disability-adjusted life years (DALYs), resulting from the sum of years of life lost (YLL) due to premature death and years lost due to disability (YLD). YLL were estimated based on the Portuguese mortality rates reported by the European Detailed Mortality Database...
January 8, 2019: ESC Heart Failure
Emanuele Bobbio, Niklas Forsgard, Anders Oldfors, Piotr Szamlewski, Entela Bollano, Bert Andersson, Marie Lingbrant, Niklas Bergh, Kristjan Karason, Christian L Polte
We report the case of a 38-year-old man who presented with cardiac arrest 1 year after curative liver transplantation for Wilson's disease. Clinical work-up proofed myocardial copper and iron accumulation using mass spectrometry, which led most likely to myocardial fibrosis as visualized by cardiovascular magnetic resonance (unprecedented delayed enhancement pattern) and endomyocardial biopsy. Consequently, cardiac arrest due to ventricular fibrillation and subsequent episodes of sustained ventricular tachycardia were considered as primary cardiac manifestation of Wilson's disease...
January 8, 2019: ESC Heart Failure
Osami Kawarada, Teruyoshi Kume, Kan Zen, Shigeru Nakamura, Koji Hozawa, Tadafumi Akimitsu, Hiroshi Asano, Hiroshi Ando, Yoshito Yamamoto, Takehiro Yamashita, Norihiko Shinozaki, Keita Odashiro, Tadaya Sato, Kenichiro Yuba, Yuji Sakanoue, Takashi Uzu, Kozo Okada, Peter J Fitzgerald, Yasuhiro Honda, Satoshi Yasuda
AIMS: Consensus-derived guidelines recommend renal stenting for patients with atherosclerotic renal artery disease (ARAD) and heart failure (HF). The aim of this prospective multi-centre observational study was to verify our hypothesis that changes in E/e', an echocardiographic correlate of left ventricular (LV) filling pressure, following renal stenting may differ between ARAD patients with and without HF. METHODS AND RESULTS: This study enrolled de novo ARAD patients undergoing renal stenting at 14 institutions...
January 7, 2019: ESC Heart Failure
Jesse F Veenis, Olivier C Manintveld, Alina A Constantinescu, Kadir Caliskan, Ozcan Birim, Jos A Bekkers, Nicolas M van Mieghem, Corstiaan A den Uil, Eric Boersma, Mattie J Lenzen, Felix Zijlstra, William T Abraham, Philip B Adamson, Jasper J Brugts
AIMS: We aim to study the feasibility and clinical value of pulmonary artery pressure monitoring with the CardioMEMS™ device in order to optimize and guide treatment in patients with a HeartMate 3 left ventricular assist device (LVAD). METHODS AND RESULTS: In this single-centre, prospective pilot study, we will include 10 consecutive patients with New York Heart Association Class IIIb or IV with Interagency Registry for Mechanically Assisted Circulatory Support Classes 2-5 scheduled for implantation of a HeartMate 3 LVAD...
January 7, 2019: ESC Heart Failure
Jubran Boulos, Wisam Darawsha, Zaid A Abassi, Zaher S Azzam, Doron Aronson
AIMS: In the present study, we aimed to determine the relationship between therapeutic decisions during the treatment of acute heart failure (AHF) patients who develop acute kidney injury (AKI) and subsequent renal and clinical outcomes. METHODS AND RESULTS: We studied 277 patients with AHF and AKI, defined as an increase of >0.3 mg/dL in serum creatinine. The physician response to AKI was determined through a treatment composite score that captured changes in medical management in response to AKI, including a reduction (≥50%) or discontinuation of selected medication classes [angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACE-Is/ARBs), beta-blockers, and diuretics] and fluids administration...
December 19, 2018: ESC Heart Failure
Tsuyoshi Suzuki, Sandra Palus, Jochen Springer
Patients suffering from chronic heart failure (CHF) show an increased prevalence (~20% in elderly CHF patients) of loss of muscle mass and muscle function (i.e. sarcopenia) compared with healthy elderly people. Sarcopenia, which can also occur in obese patients, is considered a strong predictor of frailty, disability, and mortality in older persons and is present in 5-13% of elderly persons aged 60-70 years and up to 50% of all octogenarians. In a CHF study, sarcopenia was associated with lower strength, reduced peak oxygen consumption (peak VO2 , 1173 ± 433 vs...
December 7, 2018: ESC Heart Failure
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