journal
https://read.qxmd.com/read/38791095/a-primer-for-utilizing-deep-learning-and-abdominal-mri-imaging-features-to-monitor-autosomal-dominant-polycystic-kidney-disease-progression
#1
REVIEW
Chenglin Zhu, Xinzi He, Jon D Blumenfeld, Zhongxiu Hu, Hreedi Dev, Usama Sattar, Vahid Bazojoo, Arman Sharbatdaran, Mohit Aspal, Dominick Romano, Kurt Teichman, Hui Yi Ng He, Yin Wang, Andrea Soto Figueroa, Erin Weiss, Anna G Prince, James M Chevalier, Daniil Shimonov, Mina C Moghadam, Mert Sabuncu, Martin R Prince
Abdominal imaging of autosomal dominant polycystic kidney disease (ADPKD) has historically focused on detecting complications such as cyst rupture, cyst infection, obstructing renal calculi, and pyelonephritis; discriminating complex cysts from renal cell carcinoma; and identifying sources of abdominal pain. Many imaging features of ADPKD are incompletely evaluated or not deemed to be clinically significant, and because of this, treatment options are limited. However, total kidney volume (TKV) measurement has become important for assessing the risk of disease progression (i...
May 20, 2024: Biomedicines
https://read.qxmd.com/read/38791094/comparative-evaluation-of-dental-enamel-microhardness-following-various-methods-of-interproximal-reduction-a-vickers-hardness-tester-investigation
#2
JOURNAL ARTICLE
Dan-Cosmin Serbanoiu, Aurel-Claudiu Vartolomei, Dana-Valentina Ghiga, Silvia Izabella Pop, Irinel Panainte, Marioara Moldovan, Codruta Sarosi, Ioan Petean, Marie-Jose Boileau, Mariana Pacurar
Interproximal enamel reduction, also known as stripping, is a common orthodontic procedure that reduces the mesiodistal diameter of teeth, allowing for a balance of available space in dental arches. The aim of this study was to assess the enamel surface microhardness resulting from the application of currently available methods for interproximal reduction. Forty-two extracted human permanent teeth were divided into six different groups, each subjected to a therapeutic stripping procedure using various methods (i...
May 20, 2024: Biomedicines
https://read.qxmd.com/read/38791093/can-microfluidics-improve-sperm-quality-a-prospective-functional-study
#3
JOURNAL ARTICLE
Fernando Meseguer, Carla Giménez Rodríguez, Rocío Rivera Egea, Laura Carrión Sisternas, Jose A Remohí, Marcos Meseguer
The same sperm selection techniques in assisted reproduction clinics have remained largely unchanged despite their weaknesses. Recently, microfluidic devices have emerged as a novel methodology that facilitates the sperm selection process with promising results. A prospective case-control study was conducted in two phases: 100 samples were used to compare the microfluidic device with Density Gradient, and another 100 samples were used to compare the device with the Swim-up. In the initial phase, a significant enhancement in progressive motility, total progressive motile sperm count, vitality, morphology, and sperm DNA fragmentation were obtained for the microfluidic group compared to Density Gradient...
May 20, 2024: Biomedicines
https://read.qxmd.com/read/38791092/exploring-the-role-of-guanylate-binding-protein-2-in-activated-microglia-mediated-neuroinflammation-and-neuronal-damage
#4
JOURNAL ARTICLE
Ji-Eun You, Eun-Ji Kim, Ho Won Kim, Jong-Seok Kim, Kyunggon Kim, Pyung-Hwan Kim
Neuron damage by microglia, which act as macrophage cells in the brain, can result in various brain diseases. However, the function of pro-inflammatory or anti-inflammatory microglia in the neurons remains controversial. Guanylate-binding protein-2 (GBP2) is expressed and activated in the microglia in the early phase of the inflammatory response and plays an important role in controlling immune responses. In this study, we evaluated whether GBP2 initially reduces the immune response induced by microglia, and whether microglia induce pro-inflammatory functions in neurons via GBP2 expression...
May 20, 2024: Biomedicines
https://read.qxmd.com/read/38791091/regulation-of-the-function-and-expression-of-epcam
#5
REVIEW
Di Xiao, Mingrui Xiong, Xin Wang, Mengqing Lyu, Hanxiang Sun, Yeting Cui, Chen Chen, Ziyu Jiang, Fan Sun
The epithelial cell adhesion molecule (EpCAM) is a single transmembrane protein on the cell surface. Given its strong expression on epithelial cells and epithelial cell-derived tumors, EpCAM has been identified as a biomarker for circulating tumor cells (CTCs) and exosomes and a target for cancer therapy. As a cell adhesion molecule, EpCAM has a crystal structure that indicates that it forms a cis-dimer first and then probably a trans-tetramer to mediate intercellular adhesion. Through regulated intramembrane proteolysis (RIP), EpCAM and its proteolytic fragments are also able to regulate multiple signaling pathways, Wnt signaling in particular...
May 20, 2024: Biomedicines
https://read.qxmd.com/read/38791090/characterizing-the-dynamic-expression-of-c1q-tnf-%C3%AE-related-protein-6-ctrp6-during-pregnancy-in-humans-and-mice-with-gestational-diabetes-mellitus
#6
JOURNAL ARTICLE
Jianan Jiang, Shuangyu Wei, Miao Chen, Yutian Tan, Zhao Yang, Guiying Yang, Weijie Feng, Zhen Han, Xiaojing Wei, Xiao Luo
AIM: C1q/TNF-related protein 6 (CTRP6) is a novel adipokine involved in insulin resistance. Thus, we aim to investigate the expression profile of CTRP6 in the plasma, adipose tissue and placenta of GDM patients and mice. METHODS: Chinese Han pregnant women (GDM n = 9, control n = 10) with a scheduled caesarean section delivery were recruited. A number of high-fat diet (HFD) induced-pregnancy C57BL/6 mice were chosen as an animal model of GDM. Circulating levels of CTRP6 and adiponectin were examined by ELISA...
May 19, 2024: Biomedicines
https://read.qxmd.com/read/38791089/associations-of-diabetes-and-hyperglycaemia-with-extent-and-outcomes-of-acute-burn-injuries
#7
JOURNAL ARTICLE
Jeffrey Chandra, Edward Raby, Fiona M Wood, P Gerry Fegan, Bu B Yeap
BACKGROUND: Severe burns may induce hyperglycaemia in the absence of diabetes, but how glucose trajectories relate to burns outcomes is unclear. AIM: To assess incidence of hyperglycaemia following acute burn injury, and associations with diabetes history and length of stay (LOS). METHODS: Retrospective cohort study of adults admitted with acute burns to tertiary centres. Blood glucose level (BGL), hyperglycaemic episodes (BGL ≥ 11...
May 19, 2024: Biomedicines
https://read.qxmd.com/read/38791088/insights-into-kidney-dysplasia-in-duplex-kidneys-from-radiologic-diagnosis-to-histopathologic-understanding
#8
JOURNAL ARTICLE
Dominik Świętoń, Kamil Buczkowski, Piotr Czarniak, Andrzej Gołębiewski, Małgorzata Grzywińska, Mariusz J Kujawa, Susan J Back, Maciej Piskunowicz, Ewa Iżycka-Świeszewska
Duplex kidney is a urinary tract anomaly commonly associated with a wide range of primary and secondary parenchymal structural abnormalities. We present a unique comparison of US and MRI findings with histopathology following partial resection of duplex kidneys due to nephropathy. We examined a group of 21 children with duplex kidneys who were qualified for heminephrectomy (24 kidney units (KU)). All patients underwent US and MRI prior to the surgery. The imaging results were compared with histopathologic findings...
May 18, 2024: Biomedicines
https://read.qxmd.com/read/38791087/the-influence-of-tacrolimus-exposure-and-metabolism-on-the-outcomes-of-kidney-transplants
#9
JOURNAL ARTICLE
Rima Maslauskiene, Ruta Vaiciuniene, Aurelija Radzeviciene, Peteris Tretjakovs, Gita Gersone, Edgaras Stankevicius, Inga Arune Bumblyte
Tacrolimus (TAC) has a narrow therapeutic window and patient-specific pharmacokinetic variability. In our study, we analyzed the association between TAC exposure, metabolism, and kidney graft outcomes (function, rejection, and histological lesions). TAC trough (C0 ), coefficient of variation (TAC CV), concentration/dose ratio (C/D), and biomarkers related to kidney injury molecule-1 (KIM-1) and neutrophil gelatinase lipocalin (NGAL) were analyzed. We examined 174 patients who were subjected to a triple immunosuppressive regimen and underwent kidney transplantation between 2017 and 2022...
May 18, 2024: Biomedicines
https://read.qxmd.com/read/38791086/an-assessment-of-semaglutide-safety-based-on-real-world-data-from-popularity-to-spontaneous-reporting-in-eudravigilance-database
#10
JOURNAL ARTICLE
Anca Butuca, Carmen Maximiliana Dobrea, Anca Maria Arseniu, Adina Frum, Adriana Aurelia Chis, Luca Liviu Rus, Steliana Ghibu, Anca Maria Juncan, Andrei Catalin Muntean, Antonina Evelina Lazăr, Felicia Gabriela Gligor, Claudiu Morgovan, Andreea Loredana Vonica-Tincu
Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treatment of type 2 diabetes mellitus (T2DM), have been approved for the treatment of obesity in patients with or without T2DM (liraglutide-LIR, semaglutide-SEM, and tirzepatide-TIR). Social media had an important influence on the off-label use of GLP-1 RAs for obesity, especially for SEM. We analyzed the Google queries related to SEM to assess people's interest in this drug. We also investigated the occurrence of adverse drug reactions (ADRs) by searching the EudraVigilance database (EV) for Individual Case Safety Reports (ICSRs) that reported SEM as the suspected drug and performed a descriptive and a disproportionality analysis...
May 18, 2024: Biomedicines
https://read.qxmd.com/read/38791085/the-association-of-death-receptors-and-tgf-%C3%AE-1-expression-in-urothelial-bladder-cancer-and-their-prognostic-significance
#11
JOURNAL ARTICLE
Slavica Stojnev, Irena Conic, Ana Ristic Petrovic, Ivan Petkovic, Milica Radic, Miljan Krstic, Ljubinka Jankovic Velickovic
Death receptor signalization that triggers the extrinsic apoptotic pathway and TGF-β1 have important roles in urothelial carcinogenesis, with a complex interplay between them. The aim of this research was to assess the association of death receptors DR4, DR5, and FAS as well as TGF-β1 immunohistochemical expression with the clinicopathological characteristics of urothelial bladder cancer (UBC) and to evaluate their prognostic significance. The decrease or loss of death receptors' expression was significantly associated with muscle-invasive tumors, while non-invasive UBC often retains the expression of death receptors, which are mutually strongly linked...
May 18, 2024: Biomedicines
https://read.qxmd.com/read/38791084/age-and-sex-dependent-effects-of-moderate-exercise-on-endogenous-pain-inhibition-in-rats
#12
JOURNAL ARTICLE
Renan F do Espírito-Santo, Sarah M Margerison, Youping Zhang, Joshua Pak, Jin Y Ro, Joyce T Da Silva
Diffuse noxious inhibitory controls (DNICs), or the pain inhibits pain phenomenon, refer to reduced pain-like behaviors that are displayed following a noxious conditioning stimulus located far from the test stimulus and have also been referred to as "descending control of nociception" when measured in awake-behaving animals. In this study, we sought to determine the impact of moderate long-term exercise on the DCN response and determine if this effect differed across age and sex. After a six-week exercise program consisting of 30 min of moderate treadmill running 5 days a week, the animals' forepaws were injected with capsaicin, and DCN responses were assessed using thermal withdrawal latencies of the hind paw...
May 18, 2024: Biomedicines
https://read.qxmd.com/read/38791083/assessing-the-effectiveness-of-eslicarbazepine-acetate-in-reducing-audiogenic-reflex-seizures-in-the-gash-sal-model-of-epilepsy
#13
JOURNAL ARTICLE
Jaime Gonçalves-Sánchez, Thomas Ramírez-Santos, Dolores E López, Jesús M Gonçalves-Estella, Consuelo Sancho
Eslicarbazepine acetate (ESL) is a third-generation antiepileptic drug indicated as monotherapy for adults with newly diagnosed epilepsy and as adjunctive therapy for the treatment of partial seizures. Our aim was to assess the effectiveness and safety of both acute and repeated ESL administration against reflex audiogenic seizures, as shown by the Genetic Audiogenic Seizures Hamster from Salamanca (GASH/Sal). Animals were subject to the intraperitoneal administration of ESL, applying doses of 100, 150 and 200 mg/kg for the acute study, whereas a daily dose of 100 mg/kg was selected for the subchronic study, which lasted 14 days...
May 18, 2024: Biomedicines
https://read.qxmd.com/read/38791082/colostrum-lactoferrin-following-active-and-recovered-sars-cov-2-infections-during-pregnancy
#14
JOURNAL ARTICLE
Paulina Gaweł, Błażej Łukianowski, Katarzyna Kościelska-Kasprzak, Dorota Bartoszek, Magdalena Krajewska, Barbara Królak-Olejnik
Lactoferrin (Lf), which is particularly abundant in human breast milk during the early stages of lactation, provides protection against a variety of infections, including viral infections, and has demonstrated activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this study was to measure the concentrations of Lf in the colostrum of mothers with active coronavirus disease 2019 (COVID-19) infections during delivery, in mothers with a history of COVID-19 during pregnancy, and in non-infected controls...
May 17, 2024: Biomedicines
https://read.qxmd.com/read/38791081/remission-factors-for-ustekinumab-treatment-of-ulcerative-colitis-a-multicenter-retrospective-study-of-real-world-data-in-japan
#15
JOURNAL ARTICLE
Masashi Omori, Tomoyoshi Shibuya, Hirotaka Ishino, Yuka Fukuo, Rina Odakura, Masao Koma, Takafumi Maruyama, Kentaro Ito, Mayuko Haraikawa, Kei Nomura, Shintaro Yano, Osamu Nomura, Dai Ishikawa, Mariko Hojo, Taro Osada, Akihito Nagahara
Ustekinumab (UST) is an anti-IL-12/23p40 monoclonal antibody used to treat inflammatory bowel disease. The aim of this retrospective, multicenter study was to investigate the effectiveness of UST administration in achieving remission in patients with ulcerative colitis (UC) and to determine patient characteristics that influence its effectiveness. Of 88 UC patients who received UST from March 2020 to August 2023, 47 with traceable data and for whom 56 weeks had elapsed since the start of treatment received UST to induce remission...
May 17, 2024: Biomedicines
https://read.qxmd.com/read/38791080/a-novel-bifunctional-fusion-protein-anti-il-17a-sst2-protects-against-acute-liver-failure-modulating-the-tlr4-myd88-pathway-and-nlrp3-inflammasome-activation
#16
JOURNAL ARTICLE
Yu Bai, Rongrui Zhou, Xinlei Xie, An Zhu, Yanyang Nan, Tao Wu, Xiaozhi Hu, Zhonglian Cao, Dianwen Ju, Jiajun Fan
Acute liver failure (ALF) is a serious inflammatory disorder with high mortality rates, which poses a significant threat to human health. The IL-33/ST2 signal is a crucial regulator in inflammation responses associated with lipopolysaccharide (LPS)-induced macrophages. The IL-17A signaling pathway promotes the release of chemokines and inflammatory cytokines, recruiting neutrophils and T cells under LPS stimulation, thus facilitating inflammatory responses. Here, the potential therapeutic benefits of neutralizing the IL-17A signal and modulating the IL-33/ST2 signal in ALF were investigated...
May 17, 2024: Biomedicines
https://read.qxmd.com/read/38791079/clinical-developments-and-challenges-in-treating-fgfr2-driven-gastric-cancer
#17
REVIEW
David K Lau, Jack P Collin, John M Mariadason
Recent advances in the treatment of gastric cancer (GC) with chemotherapy, immunotherapy, anti-angiogenic therapy and targeted therapies have yielded some improvement in survival outcomes; however, metastatic GC remains a lethal malignancy and amongst the leading causes of cancer-related mortality worldwide. Importantly, the ongoing molecular characterisation of GCs continues to uncover potentially actionable molecular targets. Among these, aberrant FGFR2-driven signalling, predominantly arising from FGFR2 amplification, occurs in approximately 3-11% of GCs...
May 17, 2024: Biomedicines
https://read.qxmd.com/read/38791078/ifn-%C3%AE-il-17a-il-4-and-il-13-potential-biomarkers-for-prediction-of-the-effectiveness-of-biologics-in-psoriasis-patients
#18
JOURNAL ARTICLE
Ching-Liang Hsieh, Sheng-Jie Yu, Kuo-Lung Lai, Wei-Ting Chao, Chung-Yang Yen
Biologics are widely used to treat moderate-to-severe psoriasis. However, we have unmet needs for predicting individual patient responses to biologics before starting psoriasis treatment. We investigate a reliable platform and biomarkers for predicting individual patient responses to biologics. In a cohort study between 2018 and 2023 from a referral center in Taiwan, twenty psoriasis patients with or without psoriatic arthritis who had ever experienced two or more biologics were enrolled. Peripheral blood mononuclear cells obtained from these patients were treated with Streptococcus pyogenes and different biologics...
May 17, 2024: Biomedicines
https://read.qxmd.com/read/38791077/whole-body-photobiomodulation-therapy-propels-the-fibromyalgia-patient-into-the-recomposition-phase-a-reflexive-thematic-analysis
#19
JOURNAL ARTICLE
Bethany C Fitzmaurice, Rebecca L Grenfell, Nicola R Heneghan, Asius T A Rayen, Andrew A Soundy
BACKGROUND: Recent evidence has identified great promise for the novel whole-body photobiomodulation therapy (PBMT) for individuals with fibromyalgia (FM). However, currently no evidence has documented the experiences of participants. The objective of this study was to qualitatively assess treatment experience and response in a group of participants with FM undergoing a course of whole-body PBMT. METHODS: An interpretive hermeneutic phenomenological study situated within the worldview of pragmatism was undertaken...
May 17, 2024: Biomedicines
https://read.qxmd.com/read/38791076/recurrent-acute-coronary-syndrome-in-young-man-with-familial-hypercholesterolemia-efficacy-of-evolocumab-add-on-treatment-demonstrated-via-serial-coronary-angiography
#20
Narae Kim, Jin-Man Cho, In-Ho Yang
In patients with acute coronary syndrome (ACS), lipid-lowering therapy plays an important role in the prevention of the recurrence of cardiovascular disease. Recent guidelines recommend the use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in patients with ACS if their low-density lipoprotein cholesterol (LDL-C) levels are not adequately controlled with statins and ezetimibe. Based on this, we report a case in which administering a PCSK9 inhibitor successfully lowered the patient's LDL-C level to the target level and managed the coronary artery disease (CAD) recurrence...
May 17, 2024: Biomedicines
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