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Journal Article
Review
Cardiovascular Aging: Spotlight on Mitochondria.
American Journal of Physiology. Heart and Circulatory Physiology 2023 December 2
Mitochondria are cellular organelles critical for ATP production and are particularly relevant to cardiovascular diseases including heart failure, atherosclerosis, ischemia reperfusion injury, and cardiomyopathies. With advancing age, even in the absence of clinical disease, mitochondrial homeostasis becomes disrupted (e.g. redox balance, mitochondrial DNA damage, oxidative metabolism, and mitochondrial quality control). Mitochondrial dysregulation leads to the accumulation of damaged and dysfunctional mitochondria, producing excessive reactive oxygen species and perpetuating mitochondrial dysfunction. Additionally, mitochondrial DNA, cardiolipin, and N-formyl peptides are potent activators of cell-intrinsic and extrinsic inflammatory pathways. These age-related mitochondrial changes contribute to development of cardiovascular diseases. This review covers the impact of aging on mitochondria and links these mechanisms to therapeutic implications for age-associated cardiovascular diseases.
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