journal
https://read.qxmd.com/read/38888914/safety-and-efficacy-of-concomitant-treatment-with-non-vitamin-k-antagonist-oral-anticoagulants-and-antiseizure-medications-a-propensity-score-matching-cohort-study
#1
JOURNAL ARTICLE
Michela Giustozzi, Carmen Calvello, Paolo Eusebi, Federico Paolini Paoletti, Giorgio Silvestrelli, Matteo Mazzetti, Marialuisa Silla, Alessia Bellotti, Maria Cristina Vedovati, Cecilia Becattini, Michele Romoli, Lucilla Parnetti, Maurizio Paciaroni, Cinzia Costa
Research on cerebrovascular events in atrial fibrillation (AF) patients taking non-vitamin K antagonist oral anticoagulants (NOACs) with antiseizure medications (ASMs) is limited, highlighting a significant gap in literature. We assessed thrombotic and hemorrhagic risks in patients on NOACs and ASMs versus those on NOACs or ASMs alone. We analyzed a retrospective cohort from five centers, including AF and epilepsy patients on both medications (n = 188), AF patients on NOACs (n = 298), and epilepsy patients on ASMs (n = 50), with a 3-year follow-up...
June 18, 2024: Epilepsia
https://read.qxmd.com/read/38888867/regulatory-t-cells-as-a-possible-new-target-in-epilepsy
#2
REVIEW
Evelien Hendrix, Maxime Vande Vyver, Matthew Holt, Ilse Smolders
Epilepsy is a complex chronic brain disorder with diverse clinical features that can be caused by various triggering events, such as infections, head trauma, or stroke. During epileptogenesis, various abnormalities are observed, such as altered cellular homeostasis, imbalance of neurotransmitters, tissue changes, and the release of inflammatory mediators, which in combination lead to spontaneous recurrent seizures. Regulatory T cells (Tregs), a subtype of CD4+ Foxp3+ T cells, best known for their key function in immune suppression, also seem to play a role in attenuating neurodegeneration and suppressing pathological inflammation in several brain disease states...
June 18, 2024: Epilepsia
https://read.qxmd.com/read/38881435/an-interview-with-marwa-elamin-2024-epilepsia-prize-winner-for-basic-science-research
#3
EDITORIAL
Michael R Sperling
No abstract text is available yet for this article.
June 17, 2024: Epilepsia
https://read.qxmd.com/read/38881425/an-interview-with-benjamin-d-wissel-2024-epilepsia-prize-winner-for-clinical-research
#4
EDITORIAL
Michael R Sperling
No abstract text is available yet for this article.
June 17, 2024: Epilepsia
https://read.qxmd.com/read/38881333/a-systematic-review-and-meta-analysis-of-ketamine-in-pediatric-status-epilepticus
#5
REVIEW
Nicolas Chiriboga, Thomas Spentzas, Renad Abu-Sawwa
OBJECTIVE: Status epilepticus (SE) is a common neurological medical emergency in the pediatric population, with 10%-40% of cases progressing to refractory SE (RSE), requiring treatment with anesthetic infusions. We present a systematic review and meta-analysis of the use of ketamine for the treatment of pediatric SE and its potential advantages over other anesthetic infusions. METHODS: This review follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement...
June 17, 2024: Epilepsia
https://read.qxmd.com/read/38878272/cross-cultural-application-of-the-international-classification-of-cognitive-disorders-in-epilepsy-cognitive-phenotypes-in-people-with-temporal-lobe-epilepsy-in-india
#6
JOURNAL ARTICLE
Urvashi Shah, Shivani Rajeshree, Aparna Sahu, Mayuri Kalika, Sangeeta Ravat, Anny Reyes, Alena Stasenko, Robyn M Busch, Bruce P Hermann, Carrie R McDonald
OBJECTIVE: Efforts to understand the global variability in cognitive profiles in patients with epilepsy have been stymied by the lack of a standardized diagnostic system. This study examined the cross-cultural applicability of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) in a cohort of patients with temporal lobe epilepsy (TLE) in India that was diverse in language, education, and cultural background. METHODS: A cohort of 548 adults with TLE from Mumbai completed a presurgical comprehensive neuropsychological evaluation...
June 15, 2024: Epilepsia
https://read.qxmd.com/read/38878057/addressing-the-problems-of-treatment-failure-in-epilepsy-you-cannot-fix-what-you-do-not-understand
#7
JOURNAL ARTICLE
Edward H Bertram, F Edward Dudek
No abstract text is available yet for this article.
June 15, 2024: Epilepsia
https://read.qxmd.com/read/38864472/time-to-prerandomization-seizure-count-design-sufficiently-assessed-the-safety-and-tolerability-of-perampanel-for-the-treatment-of-primary-generalized-tonic-clonic-seizures
#8
JOURNAL ARTICLE
Wesley T Kerr, Leock Y Ngo, Liang Zhu, Anna Patten, Jocelyn Y Cheng, Advith S Reddy, Jacqueline A French
OBJECTIVE: Static assignment of participants in randomized clinical trials to placebo or ineffective treatment confers risk from continued seizures. An alternative trial design of time to exceed prerandomization monthly seizure count (T-PSC) has replicated the efficacy conclusions of traditionally designed trials, with shorter exposure to placebo and ineffective treatment. Trials aim to evaluate efficacy as well as safety and tolerability; therefore, we evaluated whether this T-PSC design also could replicate the trial's safety and tolerability conclusions...
June 12, 2024: Epilepsia
https://read.qxmd.com/read/38845459/bilateral-centromedian-nucleus-of-thalamus-responsive-neurostimulation-for-pediatric-onset-drug-resistant-epilepsy
#9
JOURNAL ARTICLE
Samuel Ahn, Benjamin Edmonds, Rajsekar R Rajaraman, Lekha M Rao, Shaun A Hussain, Joyce H Matsumoto, Raman Sankar, Noriko Salamon, Aria Fallah, Hiroki Nariai
Neuromodulation therapies offer an efficacious treatment alternative for patients with drug-resistant epilepsy (DRE), particularly those unlikely to benefit from surgical resection. Here we present our retrospective single-center case series of patients with pediatric-onset DRE who underwent responsive neurostimulation (RNS) depth electrode implantation targeting the bilateral centromedian nucleus (CM) of the thalamus between October 2020 and October 2022. Sixteen patients were identified; seizure outcomes, programming parameters, and complications at follow-up were reviewed...
June 7, 2024: Epilepsia
https://read.qxmd.com/read/38845414/mesial-temporal-lobe-spiking-reveals-distinct-patterns-of-blood-oxygen-level-dependent-functional-magnetic-resonance-imaging-activation-using-simultaneous-intracranial-electroencephalography-functional-magnetic-resonance-imaging
#10
JOURNAL ARTICLE
Antis G George, Craig A Beers, William Wilson, Victoria Mosher, Daniel J Pittman, Perry Dykens, Joseph S Peedicail, Laura Gill, Ismael Gaxiola-Valdez, Bradley G Goodyear, Pierre LeVan, Paolo Federico
OBJECTIVE: Temporal lobe epilepsy (TLE) has a high probability of becoming drug resistant and is frequently considered for surgical intervention. However, 30% of TLE cases have nonlesional magnetic resonance imaging (MRI) scans, which is associated with worse surgical outcomes. Characterizing interactions between temporal and extratemporal structures in these patients may help understand these poor outcomes. Simultaneous intracranial electroencephalography-functional MRI (iEEG-fMRI) can measure the hemodynamic changes associated with interictal epileptiform discharges (IEDs) recorded directly from the brain...
June 7, 2024: Epilepsia
https://read.qxmd.com/read/38845412/scn8a-self-limited-infantile-epilepsy-does-epilepsy-resolve
#11
JOURNAL ARTICLE
Emma Young, Rebekah Harris, Nico Lieffering, Guillem de Valles-Ibáñez, Denis Nyaga, Mark F Bennett, Michael S Hildebrand, Ingrid E Scheffer, Lynette G Sadleir
SCN8A variants cause a spectrum of epilepsy phenotypes ranging from self-limited infantile epilepsy (SeLIE) to developmental and epileptic encephalopathy. SeLIE is an infantile onset focal epilepsy, occurring in developmentally normal infants, which often resolves by 3 years. Our aim was to ascertain when epilepsy resolves in SCN8A-SeLIE. We identified unpublished individuals with SCN8A-SeLIE and performed detailed phenotyping. Literature was searched for published SCN8A-SeLIE cases. Nine unpublished individuals from four families were identified (age at study = 3...
June 7, 2024: Epilepsia
https://read.qxmd.com/read/38837761/trends-in-management-of-patients-with-new-onset-refractory-status-epilepticus-norse-from-2016-to-2023-an-interim-analysis
#12
JOURNAL ARTICLE
Aurelie Hanin, Anthony D Jimenez, Margaret Gopaul, Hannah Asbell, Seyhmus Aydemir, Maysaa Merhi Basha, Ayush Batra, Charlotte Damien, Gregory S Day, Onome Eka, Krista Eschbach, Safoora Fatima, Madeline C Fields, Brandon Foreman, Elizabeth E Gerard, Teneille E Gofton, Hiba A Haider, Stephen T Hantus, Sara Hocker, Amy Jongeling, Mariel Kalkach Aparicio, Padmaja Kandula, Peter Kang, Karnig Kazazian, Marissa A Kellogg, Minjee Kim, Jong Woo Lee, Lara V Marcuse, Christopher M McGraw, Wazim Mohamed, Janet Orozco, Cederic M Pimentel, Vineet Punia, Alexandra M Ramirez, Claude Steriade, Aaron F Struck, Olga Taraschenko, Andrew K Treister, Mark S Wainwright, Ji Yeoun Yoo, Sahar Zafar, Daniel J Zhou, Deepti Zutshi, Nicolas Gaspard, Lawrence J Hirsch
In response to the evolving treatment landscape for new-onset refractory status epilepticus (NORSE) and the publication of consensus recommendations in 2022, we conducted a comparative analysis of NORSE management over time. Seventy-seven patients were enrolled by 32 centers, from July 2016 to August 2023, in the NORSE/FIRES biorepository at Yale. Immunotherapy was administered to 88% of patients after a median of 3 days, with 52% receiving second-line immunotherapy after a median of 12 days (anakinra 29%, rituximab 25%, and tocilizumab 19%)...
June 5, 2024: Epilepsia
https://read.qxmd.com/read/38837755/long-term-evaluation-of-anterior-thalamic-deep-brain-stimulation-for-epilepsy-in-the-european-more-registry
#13
JOURNAL ARTICLE
Elisabeth Kaufmann, Jukka Peltola, Albert J Colon, Kai Lehtimäki, Milan Majtanik, Jürgen K Mai, Beata Bóné, Carla Bentes, Volker Coenen, Antonio Gil-Nagel, Antonio J Goncalves-Ferreira, Philippe Ryvlin, Rod Taylor, Thomas C Brionne, Frans Gielen, Shannon Song, Paul Boon
OBJECTIVE: Short-term outcomes of deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) were reported for people with drug-resistant focal epilepsy (PwE). Because long-term data are still scarce, the Medtronic Registry for Epilepsy (MORE) evaluated clinical routine application of ANT-DBS. METHODS: In this multicenter registry, PwE with ANT-DBS were followed up for safety, efficacy, and battery longevity. Follow-up ended after 5 years or upon study closure...
June 5, 2024: Epilepsia
https://read.qxmd.com/read/38837428/autonomic-biosignals-seizure-detection-and-forecasting
#14
JOURNAL ARTICLE
Gadi Miron, Mustafa Halimeh, Jesper Jeppesen, Tobias Loddenkemper, Christian Meisel
Wearable devices have attracted significant attention in epilepsy research in recent years for their potential to enhance patient care through improved seizure monitoring and forecasting. This narrative review presents a detailed overview of the current clinical state of the art while addressing how devices that assess autonomic nervous system (ANS) function reflect seizures and central nervous system (CNS) state changes. This includes a description of the interactions between the CNS and the ANS, including physiological and epilepsy-related changes affecting their dynamics...
June 5, 2024: Epilepsia
https://read.qxmd.com/read/38837385/quantitative-cellular-pathology-of-the-amygdala-in-temporal-lobe-epilepsy-and-correlation-with-magnetic-resonance-imaging-volumetry-tissue-microstructure-and-sudden-unexpected-death-in-epilepsy-risk-factors
#15
JOURNAL ARTICLE
Hou Wang Lam, Smriti Patodia, Claudia Zeicu, Yau Mun Lim, Alicja Mrzyglod, Catherine Scott, Joana Oliveira, Jane De Tisi, Antoine Legouhy, Hui Zhang, Matthias Koepp, Beate Diehl, Maria Thom
OBJECTIVE: Amygdala enlargement can occur in temporal lobe epilepsy, and increased amygdala volume is also reported in sudden unexpected death in epilepsy (SUDEP). Apnea can be induced by amygdala stimulation, and postconvulsive central apnea (PCCA) and generalized seizures are both known SUDEP risk factors. Neurite orientation dispersion and density imaging (NODDI) has recently provided additional information on altered amygdala microstructure in SUDEP. In a series of 24 surgical temporal lobe epilepsy cases, our aim was to quantify amygdala cellular pathology parameters that could predict enlargement, NODDI changes, and ictal respiratory dysfunction...
June 5, 2024: Epilepsia
https://read.qxmd.com/read/38837227/excess-prevalence-of-preexisting-chronic-conditions-in-older-adults-with-incident-epilepsy
#16
JOURNAL ARTICLE
Siran M Koroukian, Hannah L Fein, Long Vu, Wyatt P Bensken, Nicholas K Schiltz, Martha Sajatovic, Gena R Ghearing, David F Warner
OBJECTIVE: Prior studies have examined chronic conditions in older adults with prevalent epilepsy, but rarely among those with incident epilepsy. Identifying the chronic conditions with which older adults present at epilepsy incidence assists with the evaluation of disease burden in this patient population and informs coordinated care development. The aim of this study was to identify preexisting chronic conditions with excess prevalence in older adults with incident epilepsy compared to those without...
June 4, 2024: Epilepsia
https://read.qxmd.com/read/38829313/wonoep-2022-neurotechnology-for-the-diagnosis-of-epilepsy
#17
REVIEW
Konrad Wagstyl, Katja Kobow, Pablo M Casillas-Espinosa, Andrew J Cole, Diego Jiménez-Jiménez, Hiroki Nariai, Stéphanie Baulac, Terence O'Brien, David C Henshall, Ozlem Akman, Raman Sankar, Aristea S Galanopoulou, Stéphane Auvin
Epilepsy's myriad causes and clinical presentations ensure that accurate diagnoses and targeted treatments remain a challenge. Advanced neurotechnologies are needed to better characterize individual patients across multiple modalities and analytical techniques. At the XVIth Workshop on Neurobiology of Epilepsy: Early Onset Epilepsies: Neurobiology and Novel Therapeutic Strategies (WONOEP 2022), the session on "advanced tools" highlighted a range of approaches, from molecular phenotyping of genetic epilepsy models and resected tissue samples to imaging-guided localization of epileptogenic tissue for surgical resection of focal malformations...
June 3, 2024: Epilepsia
https://read.qxmd.com/read/38819633/imbalance-between-hippocampal-projection-cell-and-parvalbumin-interneuron-architecture-increases-epileptic-susceptibility-in-mouse-model-of-methyl-cpg-binding-protein-2-duplication-syndrome
#18
JOURNAL ARTICLE
Junye Ge, Shengjun Xie, Jiamei Duan, Biqing Tian, Pengfei Ren, Erling Hu, Qiyi Huang, Honghui Mao, Yuxin Zou, Qian Chen, Wenting Wang
OBJECTIVE: Methyl CpG-binding protein 2 (MECP2) duplication syndrome is a rare X-linked genomic disorder affecting predominantly males, which is usually manifested as epilepsy and autism spectrum disorder (ASD) comorbidity. The transgenic line MeCP2Tg1 was used for mimicking MECP2 duplication syndrome and showed autism-epilepsy co-occurrence. Previous works suggested that the excitatory/inhibitory (E/I) imbalance is a potential common mechanism for both epilepsy and ASD. The projection neurons and parvalbumin (PV) interneurons account for the majority of E/I balance in the hippocampus...
May 31, 2024: Epilepsia
https://read.qxmd.com/read/38813894/correction-to-fenfluramine-provides-clinically-meaningful-reduction-in-frequency-of-drop-seizures-in-patients-with-lennox-gastaut-syndrome-interim-analysis-of-an-open-label-extension-study
#19
https://read.qxmd.com/read/38808646/-is-it-a-seizure-prediction-tool-for-seizure-likelihood-in-children-aged-1-24%C3%A2-months-admitted-for-electroencephalographic-monitoring-of-paroxysmal-rhythmic-and-repetitive-events
#20
JOURNAL ARTICLE
Melisa Carrasco, Theresa Estiphan, Harlan McCaffery, Nancy McNamara
OBJECTIVE: Paroxysmal, rhythmic, and repetitive events (PRREs) during infancy can be concerning for possible seizures, especially following perinatal brain injuries. The workup for establishing whether a PRRE represents a seizure involves the use of continuous video-electroencephalography (cVEEG) for event characterization. This study aims to determine the diagnostic yield of cVEEG for evaluating events concerning for seizures in children aged 1-24 months. METHODS: We performed a single-center retrospective chart review (January 1, 2019-December 31, 2020) and included all children aged 1-24 months admitted for PRRE capture and characterization using cVEEG...
May 29, 2024: Epilepsia
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