journal
https://read.qxmd.com/read/38032046/visually-or-auditorily-induced-seizures-involve-the-activation-of-nonhippocampal-brain-areas-and-hippocampal-removal-does-not-alleviate-seizures-in-a-mouse-model-of-temporal-lobe-epilepsy
#1
JOURNAL ARTICLE
Stephen Temitayo Bello, Shenghui Xu, Xiao Li, Junming Ren, Peter Jendrichovsky, Feixu Jiang, Zhoujian Xiao, Xiaoxiao Wan, Xi Chen, Jufang He
OBJECTIVE: Several studies have attributed epileptic activities in temporal lobe epilepsy (TLE) to the hippocampus; however, the participation of nonhippocampal neuronal networks in the development of TLE is often neglected. Here, we sought to understand how these nonhippocampal networks are involved in the pathology that is associated with TLE disease. METHODS: A kainic acid (KA) model of temporal lobe epilepsy was induced by injecting KA into dorsal hippocampus of C57BL/6J mice...
November 30, 2023: Epilepsia
https://read.qxmd.com/read/38031503/transmembrane-ampa-receptor-regulatory-proteins-expression-during-the-development-of-absence-seizures-in-the-genetic-absence-epilepsy-rats-from-strasbourg
#2
JOURNAL ARTICLE
Pablo M Casillas-Espinosa, Runxuan Lin, Rui Li, Kim L Powell, Terence J O'Brien
The transmembrane AMPA receptor regulatory proteins(TARPs), γ2(stargazin), γ3, γ4, γ5, γ7 and γ8, are a family of proteins that regulate AMPAR trafficking, expression, and biophysical properties that could have a role in the development of absence seizures. Here, we evaluated the expression of TARPs and AMPA receptors across the development of epilepsy in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model of idiopathic generalised epilepsy (IGE) with absence seizures...
November 30, 2023: Epilepsia
https://read.qxmd.com/read/38031640/long-term-intellectual-and-developmental-outcomes-after-pediatric-epilepsy-surgery-a-systematic-review-and-meta-analysis
#3
REVIEW
Ilona Stefanos-Yakoub, Kevin Wingeier, Ulrike Held, Beatrice Latal, Elaine Wirrell, Mary Lou Smith, Georgia Ramantani
OBJECTIVE: In addition to the primary aim of seizure freedom, a key secondary aim of pediatric epilepsy surgery is to stabilize and, potentially, optimize cognitive development. While the efficacy of surgical treatment for seizure control has been established, the long-term intellectual and developmental trajectories are yet to be delineated. METHODS: We conducted a systematic review and meta-analysis of studies reporting pre- and postsurgical intelligence or developmental quotients (IQ/DQ) of children with focal lesional epilepsy aged ≤18 years at epilepsy surgery and assessed at >2 years after surgery...
November 29, 2023: Epilepsia
https://read.qxmd.com/read/38031477/temporal-relationship-between-levetiracetam-nonadherence-and-breakthrough-seizures-in-a-preclinical-model-of-temporal-lobe-epilepsy
#4
JOURNAL ARTICLE
Michelle Guignet, Jonathan Vuong, Alejandra Martinez, Ticha Ballapapinan, H Steve White
OBJECTIVE: Poor medication adherence remains a concern for individuals managing their epilepsy with antiseizure medicines; however, ethical concerns around withholding medication make it impossible to study the causal relationship between missed doses and seizures in patients. Previous preclinical studies from our group suggest that mechanistically distinct ASMs have varying degrees of forgiveness when a dose is missed. However, with only a few ASMs studied in the context of nonadherence, we sought to expand on previous work to understand the relationship between levetiracetam (LEV) nonadherence and breakthrough seizures...
November 29, 2023: Epilepsia
https://read.qxmd.com/read/38014851/correction-to-perampanel-as-precision-therapy-in-rare-genetic-epilepsies
#5
(no author information available yet)
No abstract text is available yet for this article.
November 28, 2023: Epilepsia
https://read.qxmd.com/read/38014587/long-term-physical-and-psychiatric-morbidities-and-mortality-of-untreated-deferred-and-immediately-treated-epilepsy
#6
JOURNAL ARTICLE
Tianrui Ren, Yingtong Li, Michael Burgess, Sameer Sharma, Maria Rychkova, John Dunne, Judy Lee, Cédric Laloyaux, Nicholas Lawn, Patrick Kwan, Zhibin Chen
OBJECTIVE: In Australia, 30% of newly diagnosed epilepsy patients were not immediately treated at diagnosis. We explored health outcomes between patients receiving immediate, deferred, or no treatment, and compared them to the general population. METHODS: Adults with newly diagnosed epilepsy in Western Australia between 1999 and 2016 were linked with statewide health care data collections. Health care utilization, comorbidity, and mortality at up to 10 years postdiagnosis were compared between patients receiving immediate, deferred, and no treatment, as well as with age- and sex-matched population controls...
November 28, 2023: Epilepsia
https://read.qxmd.com/read/38010146/the-extent-of-cyp3a-induction-by-antiseizure-medications-a-systematic-review-and-network-meta-analysis
#7
JOURNAL ARTICLE
Hagar Cohen, Ghadeer Mahajna, Tomer Ben-Shushan, Ilan Matok, Sara Eyal
OBJECTIVE: Antiseizure medications (ASMs) are commonly categorized as enzyme-inducers and non-enzyme inducers based on their propensity to enhance the metabolism of concomitantly administered drugs. This systematic review and network meta-analysis aimed to rank individual ASMs as cytochrome P450 (CYP)3A inducers based on a comparative assessment of ASM-induced reduction in the concentrations of sensitive substrate drugs. METHODS: The protocol was registered with PROSPERO (CRD42022335846), and the PRISMA standards were followed...
November 27, 2023: Epilepsia
https://read.qxmd.com/read/38009669/assumptions-and-statistical-inference
#8
LETTER
Kathryn Nichol, Ryan Verner, Charles Gordon, Danielle Urry
No abstract text is available yet for this article.
November 27, 2023: Epilepsia
https://read.qxmd.com/read/37991184/introduction-special-issue-ictals-2022
#9
JOURNAL ARTICLE
Maxime O Baud, Christian Rummel
No abstract text is available yet for this article.
November 22, 2023: Epilepsia
https://read.qxmd.com/read/37983643/interaction-of-interictal-epileptiform-activity-with-sleep-spindles-is-associated-with-cognitive-deficits-and-adverse-surgical-outcome-in-pediatric-focal-epilepsy
#10
JOURNAL ARTICLE
Han Yu, Woojoong Kim, David K Park, Ji Hoon Phi, Byung Chan Lim, Jong-Hee Chae, Seung-Ki Kim, Ki Joong Kim, Frank A Provenzano, Dion Khodagholy, Jennifer N Gelinas
OBJECTIVE: Temporal coordination between oscillations enables intercortical communication and is implicated in cognition. Focal epileptic activity can affect distributed neural networks and interfere with these interactions. Refractory pediatric epilepsies are often accompanied by substantial cognitive comorbidity, but mechanisms and predictors remain mostly unknown. Here, we investigate oscillatory coupling across large-scale networks in the developing brain. METHODS: We analyzed large-scale intracranial electroencephalographic recordings in children with medically refractory epilepsy undergoing presurgical workup (n = 25, aged 3-21 years)...
November 20, 2023: Epilepsia
https://read.qxmd.com/read/37983589/artificial-intelligence-in-epilepsy-phenotyping
#11
JOURNAL ARTICLE
Andrew Knight, Tilo Gschwind, Peter Galer, Gregory A Worrell, Brian Litt, Ivan Soltesz, Sándor Beniczky
Artificial intelligence (AI) allows data analysis and integration at an unprecedented granularity and scale. Here we review the technological advances, challenges and future perspectives of using AI for electro-clinical phenotyping of animal models and patients with epilepsy. In translational research AI models accurately identify behavioral states in animal models of epilepsy, allowing identification of correlations between neural activity and interictal and ictal behavior. Clinical applications of AI-based automated and semi-automated analysis of audio and video recordings of people with epilepsy, allow significant data reduction and reliable detection and classification of major motor seizures...
November 20, 2023: Epilepsia
https://read.qxmd.com/read/37973611/changes-in-postictal-cerebral-perfusion-are-related-to-the-duration-of-electroconvulsive-therapy-induced-seizures
#12
JOURNAL ARTICLE
Julia C M Pottkämper, Joey P A J Verdijk, Eva Aalbregt, Sven Stuiver, Laurens van de Mortel, David G Norris, Michel J A M van Putten, Jeannette Hofmeijer, Guido van Wingen, Jeroen A van Waarde
OBJECTIVE: Postictal symptoms may result from cerebral hypoperfusion which is possibly a consequence of seizure-induced vasoconstriction. Longer seizures have previously been shown to cause more severe postictal hypoperfusion in rats and epilepsy patients. We studied cerebral perfusion after generalized seizures elicited by electroconvulsive therapy (ECT) and its relation to seizure duration. METHODS: Patients with a major depressive episode who underwent ECT were included...
November 16, 2023: Epilepsia
https://read.qxmd.com/read/37966426/drug-resistance-in-epilepsy-a-reappraisal-of-the-definition-is-needed
#13
LETTER
Ali A Asadi-Pooya
No abstract text is available yet for this article.
November 15, 2023: Epilepsia
https://read.qxmd.com/read/37965804/prognostic-value-of-nonconvulsive-status-epilepticus-salzburg-criteria-the-sace-score
#14
JOURNAL ARTICLE
Francesco Misirocchi, Alessandro Zilioli, Elisa Mannini, Stefania Lazzari, Carlotta Mutti, Lucia Zinno, Liborio Parrino, Pia De Stefano, Irene Florindo
OBJECTIVE: To investigate the association between NCSE Salzburg criteria and in-hospital outcome, to determine the predictive accuracy of STESS, mSTESS, EMSE and END-IT in NCSE patients and to develop a new prognostic score specifically designed for NCSE patients. METHODS: Clinical and EEG data of adult patients treated for NCSE from 2020 to 2023 were retrospectively assessed. Age, sex, mRS at admission, comorbidities, history of seizures, etiology, SE type and outcome were collected from the patients' digital charts...
November 15, 2023: Epilepsia
https://read.qxmd.com/read/37964464/magnetic-resonance-imaging-findings-in-kenyans-and-south-africans-with-active-convulsive-epilepsy-an-observational-study
#15
JOURNAL ARTICLE
Symon M Kariuki, Ryan G Wagner, Roxana Gunny, Felice D'Arco, Martha Kombe, Anthony K Ngugi, Steven White, Rachael Odhiambo, J Helen Cross, Josemir W Sander, Charles R J C Newton
OBJECTIVE: Focal epilepsy is common in low- and middle-income countries. The frequency and nature of possible underlying structural brain abnormalities have, however, not been fully assessed. METHODS: We evaluated the possible structural causes of epilepsy in 331 people with epilepsy (240 from Kenya and 91 from South Africa) identified from community surveys of active convulsive epilepsy. Magnetic Resonance Imaging (MRI) scans were acquired on 1.5-tesla scanners to determine the frequency and nature of underlying lesions...
November 14, 2023: Epilepsia
https://read.qxmd.com/read/37953072/delays-to-care-in-infantile-epileptic-spasms-syndrome-racial-and-ethnic-inequities
#16
JOURNAL ARTICLE
Christina Briscoe Abath, Nishtha Gupta, Aristides Hadjinicolaou, Stephanie Donatelli, Avantika Singh, Sabrina Merchant, Morgan E Ryan, Meghann Soby, Christopher Ryan, Adrianne Katrina Nelson, John E Maldonado Pacheco, Bo Zhang, David N Williams, Christopher J Yuskaitis, Chellamani Harini
OBJECTIVE: Non-Hispanic (NH) Black children are less likely to receive a standard treatment course for infantile epileptic spasms syndrome (IESS) than White/NH children at pediatric tertiary care epilepsy centers in the United States. However, if inequities exist in time to diagnosis is unknown. Diagnostic delays as little as a week can be associated with worse developmental outcomes. METHODS: Diagnostic delays were evaluated in a retrospective cohort of 100 children with new onset IESS between January 2019 and May 2022...
November 12, 2023: Epilepsia
https://read.qxmd.com/read/37950390/long-term-treatment-with-ganaxolone-for-seizures-associated-with-cyclin-dependent-kinase-like-5-deficiency-disorder-2-year-open-label-extension-follow-up
#17
JOURNAL ARTICLE
Heather E Olson, Sam Amin, Nadia Bahi-Buisson, Orrin Devinsky, Eric D Marsh, Elia Pestana-Knight, Rajsekar R Rajaraman, Alex A Aimetti, Eva Rybak, Fanhui Kong, Ian Miller, Joseph Hulihan, Scott Demarest
OBJECTIVE: In the placebo-controlled, double-blind phase of the Marigold study (NCT03572933), ganaxolone significantly reduced major motor seizure frequency (MMSF) in patients with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD). We report 2-year safety and clinical outcomes data from the open-label extension (OLE) phase of Marigold. METHODS: Patients with CDD who completed the double-blind phase were eligible to continue in the OLE. Efficacy assessments included MMSF reduction from pre-randomization baseline, responder rates, and Clinical Global Impression of Improvement scale (CGI-I) scores, including assessment of seizure intensity and duration (CGI-CSID)...
November 10, 2023: Epilepsia
https://read.qxmd.com/read/37945547/climate-change-attitudes-and-concerns-of-and-learnings-from-people-with-neurological-conditions-carers-and-healthcare-professionals
#18
JOURNAL ARTICLE
Stephen Blenkinsop, Alistair Wardrope, Joseph Willis, Sanjay M Sisodiya
OBJECTIVE: Concern about climate change amongst the general public is acknowledged by surveys. The healthcare sector must play its part in reducing greenhouse gas emissions and adapting to a changing climate, which will require the support of its stakeholders including those with epilepsy who may be especially vulnerable. It is important to understand this community's attitudes and concerns about climate change and societal responses. METHODS: A survey was made available to over 100,000 people amongst a section of the neurological community (patients, carers and clinicians), focussed on epilepsy...
November 9, 2023: Epilepsia
https://read.qxmd.com/read/37945542/valproate-use-associated-with-frontal-and-cerebellar-grey-matter-volume-reductions-a-voxel-based-morphometry-study
#19
JOURNAL ARTICLE
Ji Hye Shin, Min Ji Song, Ji Hyun Kim
Recent morphometric MRI studies suggested the possibility that valproate (VPA) use is associated with parieto-occipital cortical thinning in patients with heterogeneous epilepsy syndromes. In this study, we examined the effect of VPA on the brain volume using a large number of homogenous patients with idiopathic generalized epilepsy. Voxel-based morphometry was used to compare regional grey matter (GM) volume between 112 patients currently taking VPA (VPA+ group), 81 patients not currently taking VPA (VPA- group), and 120 healthy subjects (control group)...
November 9, 2023: Epilepsia
https://read.qxmd.com/read/37943158/response-assumptions-and-statistical-inference
#20
LETTER
Zulfi Haneef, Henry C Skrehot
No abstract text is available yet for this article.
November 9, 2023: Epilepsia
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