journal
https://read.qxmd.com/read/38546705/amygdala-enlargement-in-temporal-lobe-epilepsy-histopathology-and-surgical-outcomes
#1
JOURNAL ARTICLE
Lubna Shakhatreh, Ben Sinclair, Catriona McLean, Elaine Lui, Andrew P Morokoff, James A King, Zhibin Chen, Piero Perucca, Terence J O'Brien, Patrick Kwan
OBJECTIVES: Amygdala enlargement is detected on magnetic resonance imaging (MRI) in some patients with drug-resistant temporal lobe epilepsy (TLE), but its clinical significance remains uncertain We aimed to assess if the presence of amygdala enlargement (1) predicted seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL-AH) and (2) was associated with specific histopathological changes. METHODS: This was a case-control study. We included patients with drug-resistant TLE who underwent ATL-AH with and without amygdala enlargement detected on pre-operative MRI...
March 28, 2024: Epilepsia
https://read.qxmd.com/read/38536086/frailty-as-a-comprehensive-health-measure-beyond-seizure-control-in-patients-with-epilepsy-a-cross-sectional-study
#2
JOURNAL ARTICLE
Emanuele Cerulli Irelli, Maria S Borioni, Alessandra Morano, Adolfo Mazzeo, Pierludovico Moro, Biagio Orlando, Enrico M Salamone, Luca Giordano, Alessio Petrungaro, Marco Toccaceli Blasi, Anna T Giallonardo, Marco Canevelli, Carlo Di Bonaventura
OBJECTIVE: Due to the high clinical heterogeneity of epilepsy, there is a critical need for novel metrics aimed at capturing its biological and phenotypic complexity. Frailty is increasingly recognized in various medical disciplines as a useful construct to understand differences in susceptibility to adverse outcomes. Here, we develop a frailty index (FI) for patients with epilepsy (PwE) and explore its association with demographic and clinical features. METHODS: In this cross-sectional study, we consecutively enrolled 153 PwE from an outpatient epilepsy clinic...
March 27, 2024: Epilepsia
https://read.qxmd.com/read/38536044/acetazolamide-as-an-effective-treatment-for-pilomotor-seizures-in-autoimmune-encephalitis
#3
JOURNAL ARTICLE
Kia Gilani, Apameh Tarazi, Richard Wennberg
Pilomotor seizures are strongly associated with autoimmune encephalitis (AE), particularly anti-LGI1 encephalitis. The carbonic anhydrase inhibitor acetazolamide may have special efficacy for treating AE-associated pilomotor seizures. Six patients with AE (five anti-LGI1, one seronegative) and temporal lobe pilomotor seizures (five with seizures inducible by hyperventilation) were treated with acetazolamide, administered in a cycling (2-days-ON, 4-days-OFF) regimen to offset tolerance. Seizures were assessed during epilepsy monitoring unit (EMU) recordings in four inpatients (one of whom also maintained an outpatient seizure diary chronicling 1203 seizures over 1079 days); two outpatients self-reported seizure frequencies...
March 27, 2024: Epilepsia
https://read.qxmd.com/read/38520344/correction-to-home-recording-of-3-hz-spike-wave-discharges-in-adults-with-absence-epilepsy-using-the-wearable-sensor-dot
#4
(no author information available yet)
No abstract text is available yet for this article.
March 23, 2024: Epilepsia
https://read.qxmd.com/read/38517477/edge-wise-analysis-reveals-white-matter-connectivity-associated-with-focal-to-bilateral-tonic-clonic-seizures
#5
JOURNAL ARTICLE
Sam S Javidi, Xiaosong He, Ankeeta Ankeeta, Qirui Zhang, Salvatore Citro, Michael R Sperling, Joseph I Tracy
OBJECTIVE: Focal to bilateral tonic-clonic seizures (FBTCS) represent a challenging subtype of focal temporal lobe epilepsy (TLE) in terms of both severity and treatment response. Most studies have focused on regional brain analysis that is agnostic to the distribution of white matter (WM) pathways associated with a node. We implemented a more selective, edge-wise approach that allowed for identification of the individual connections unique to FBTCS. METHODS: T1-weighted and diffusion-weighted images were obtained from 22 patients with solely focal seizures (FS), 43 FBTCS patients, and 65 age/sex-matched healthy participants (HPs), yielding streamline (STR) connectome matrices...
March 22, 2024: Epilepsia
https://read.qxmd.com/read/38517356/circadian-changes-in-aperiodic-activity-are-correlated-with-seizure-reduction-in-patients-with-mesial-temporal-lobe-epilepsy-treated-with-responsive-neurostimulation
#6
JOURNAL ARTICLE
Chantel M Charlebois, Daria Nesterovich Anderson, Elliot H Smith, Tyler S Davis, Blake J Newman, Angela Y Peters, Amir M Arain, Alan D Dorval, John D Rolston, Christopher R Butson
OBJECTIVES: Responsive neurostimulation (RNS) is an established therapy for drug-resistant epilepsy that delivers direct electrical brain stimulation in response to detected epileptiform activity. However, despite an overall reduction in seizure frequency, clinical outcomes are variable, and few patients become seizure-free. The aim of this retrospective study was to evaluate aperiodic electrophysiological activity, associated with excitation/inhibition balance, as a novel electrographic biomarker of seizure reduction to aid early prognostication of the clinical response to RNS...
March 22, 2024: Epilepsia
https://read.qxmd.com/read/38511905/combining-magnetic-resonance-fingerprinting-with-voxel-based-morphometric-analysis-to-reduce-false-positives-for-focal-cortical-dysplasia-detection
#7
JOURNAL ARTICLE
Zheng Ding, Siyuan Hu, Ting-Yu Su, Joon Yul Choi, Spencer Morris, Xiaofeng Wang, Ken Sakaie, Hiroatsu Murakami, Hans-Jürgen Huppertz, Ingmar Blümcke, Stephen Jones, Imad Najm, Dan Ma, Zhong Irene Wang
OBJECTIVE: We aim to improve focal cortical dysplasia (FCD) detection by combining high-resolution, three-dimensional (3D) magnetic resonance fingerprinting (MRF) with voxel-based morphometric magnetic resonance imaging (MRI) analysis. METHODS: We included 37 patients with pharmacoresistant focal epilepsy and FCD (10 IIa, 15 IIb, 10 mild Malformation of Cortical Development [mMCD], and 2 mMCD with oligodendroglial hyperplasia and epilepsy [MOGHE]). Fifty-nine healthy controls (HCs) were also included...
March 21, 2024: Epilepsia
https://read.qxmd.com/read/38507291/magnetic-resonance-imaging-fingerprints-of-status-epilepticus-a-case-control-study
#8
JOURNAL ARTICLE
Pilar Bosque Varela, Payam Tabaee Damavandi, Lukas Machegger, Tanja Prüwasser, Georg Zimmermann, Andreas Oellerer, Jürgen Steinbacher, Mark McCoy, Johannes Pfaff, Eugen Trinka, Giorgi Kuchukhidze
OBJECTIVE: Status epilepticus (SE) is frequently associated with peri-ictal magnetic resonance imaging (MRI) abnormalities (PMA). However, the anatomical distribution of these alterations has not been systematically studied. The aim of this study was to assess the localization patterns of PMA in patients with SE. METHODS: In this prospective case-control study, we compared the distribution and combinations of diffusion-restricted PMA to diffusion-restricted lesions caused by other neurological conditions...
March 20, 2024: Epilepsia
https://read.qxmd.com/read/38507275/status-epilepticus-is-there-a-stage-1-plus
#9
REVIEW
Giuseppe Magro, Vincenzo Laterza
In status epilepticus (SE), "time is brain." Currently, first-line therapy consists of benzodiazepines (BDZs) and SE is classified by the response to treatment; stage 2 or established SE is defined as "BDZ-resistant SE." Nonetheless, this classification does not always work, especially in the case of prolonged convulsive SE, where many molecular changes occur and γ-aminobutyric acid signaling becomes excitatory. Under these circumstances, BDZ therapy might not be optimal, and might be possibly detrimental, if given alone; as the duration of SE increases, so too does BDZ resistance...
March 20, 2024: Epilepsia
https://read.qxmd.com/read/38506645/motor-seizures-confer-overall-survival-benefit-in-who-grade-2-glioma
#10
JOURNAL ARTICLE
Sam Fairclough, Paul Chumas, John Goodden, Melissa Maguire, Ryan K Mathew
OBJECTIVE: The prevalence of epilepsy in World Health Organization (WHO) grade 2 glioma is high, with seizures being the presenting symptom in 60%-90%. We explore the epidemiology of seizures in this patient population in a regional neurosurgical center. METHODS: Electronic health records of patients with histologically-proven WHO grade 2 glioma (n = 228) were reviewed between 1997 and 2021, with data collected including patient demographics, epilepsy prevalence, and seizure semiology...
March 20, 2024: Epilepsia
https://read.qxmd.com/read/38506635/assessing-short-term-and-long-term-security-and-efficacy-of-anterior-nucleus-of-the-thalamus-deep-brain-stimulation-for-treating-drug-resistant-epilepsy-a-systematic-review-and-single-arm-meta-analysis
#11
REVIEW
Gabriel Verly, Leonardo de Barros Oliveira, Thiffany Delfino, Sávio Batista, Thiago Lopes, Vitória Carvalho, Billy McBenedict, Matheus Oliveira, Raphael Bertani, Pedro Henrique Martins da Cunha, Wellingson Paiva, Bruno Lima Pessoa
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a widespread invasive procedure for treating drug-resistant epilepsy. Nonetheless, there is a persistent debate regarding the short-term and long-term efficacy and safety of ANT-DBS. Thus we conducted a systematic review and meta-analysis. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), we searched PubMed, Cochrane, Embase, and Web of Science for studies treating refractory epilepsy with ANT-DBS...
March 20, 2024: Epilepsia
https://read.qxmd.com/read/38506370/racial-disparities-in-the-utilization-of-invasive-neuromodulation-devices-for-the-treatment-of-drug-resistant-focal-epilepsy
#12
JOURNAL ARTICLE
Juan Luis Alcala-Zermeno, Brandy Fureman, Caitlin L Grzeskowiak, Ojas Potnis, Maria Taveras, Margaret W Logan, Delanie Rybacki, Daniel Friedman, Daniel Lowenstein, Ruben Kuzniecky, Jacqueline French
Racial disparities affect multiple dimensions of epilepsy care including epilepsy surgery. This study aims to further explore these disparities by determining the utilization of invasive neuromodulation devices according to race and ethnicity in a multicenter study of patients living with focal drug-resistant epilepsy (DRE). We performed a post hoc analysis of the Human Epilepsy Project 2 (HEP2) data. HEP2 is a prospective study of patients living with focal DRE involving 10 sites distributed across the United States...
March 20, 2024: Epilepsia
https://read.qxmd.com/read/38502150/over-and-underreporting-of-seizures-how-big-is-the-problem
#13
JOURNAL ARTICLE
Timothy Hannon, Kiran M Fernandes, Victoria Wong, Ewan S Nurse, Mark J Cook
OBJECTIVE: Clinical decisions on managing epilepsy patients rely on patient accuracy regarding seizure reporting. Studies have noted disparities between patient-reported seizures and electroencephalographic (EEG) findings during video-EEG monitoring periods, chiefly highlighting underreporting of seizures, a well-recognized phenomenon. However, seizure overreporting is a significant problem discussed within the literature, although not in such a large cohort. Our aim is to quantify the over- and underreporting of seizures in a large cohort of ambulatory EEG patients...
March 19, 2024: Epilepsia
https://read.qxmd.com/read/38502122/correction-to-long-term-efficacy-and-safety-of-cannabidiol-in-patients-with-treatment-resistant-epilepsies-four-year-results-from-the-expanded-access-program
#14
(no author information available yet)
No abstract text is available yet for this article.
March 19, 2024: Epilepsia
https://read.qxmd.com/read/38498313/clinical-outcomes-among-initial-survivors-of-cryptogenic-new-onset-refractory-status-epilepsy-norse
#15
JOURNAL ARTICLE
Daniel J Costello, Elizabeth Matthews, Sidra Aurangzeb, Elisabeth Doran, Jessica Stack, Robb Wesselingh, Patricia Dugan, Hyunmi Choi, Chantal Depondt, Orrin Devinsky, Colin Doherty, Patrick Kwan, Mastura Monif, Terence J O'Brien, Arjune Sen, Nicolas Gaspard
OBJECTIVE: New-onset refractory status epilepticus (NORSE) is a rare but severe clinical syndrome. Despite rigorous evaluation, the underlying cause is unknown in 30%-50% of patients and treatment strategies are largely empirical. The aim of this study was to describe clinical outcomes in a cohort of well-phenotyped, thoroughly investigated patients who survived the initial phase of cryptogenic NORSE managed in specialist centers. METHODS: Well-characterized cases of cryptogenic NORSE were identified through the EPIGEN and Critical Care EEG Monitoring Research Consortia (CCEMRC) during the period 2005-2019...
March 18, 2024: Epilepsia
https://read.qxmd.com/read/38491959/clinical-and-molecular-characterization-of-patients-with-ywhag-related-epilepsy
#16
JOURNAL ARTICLE
Valentina Cetica, Tiziana Pisano, Gaetan Lesca, Dana Marafi, Laura Licchetta, Florence Riccardi, Davide Mei, Hon-Yin B Chung, Allan Bayat, Meena Balasubramanian, Daniel H Lowenstein, Milda Endzinienė, Maha Alotaibi, Nathalie Villeneuve, Julia Jacobs, Bertrand Isidor, Roberta Solazzi, Nicolette S den Hollander, Dragan Marjanovic, Christelle Rougeot-Jung, Julien Jung, Marion Lesieur-Sebellin, Andrea Accogli, Vincenzo Salpietro, Nebal W Saadi, Eleni Panagiotakaki, Thomas Foiadelli, Sylvia Redon, Meng-Han Tsai, Francesca Bisulli, Trine B Hammer, James R Lupski, Elena Parrini, Renzo Guerrini
OBJECTIVE: YWHAG variant alleles have been associated with a rare disease trait whose clinical synopsis includes an early onset epileptic encephalopathy with predominantly myoclonic seizures, developmental delay/intellectual disability, and facial dysmorphisms. Through description of a large cohort, which doubles the number of reported patients, we further delineate the spectrum of YWHAG-related epilepsy. METHODS: We included in this study 24 patients, 21 new and three previously described, with pathogenic/likely pathogenic variants in YWHAG...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38491957/somatic-variants-as-a-cause-of-drug-resistant-epilepsy-including-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#17
JOURNAL ARTICLE
Robert J Carton, Michael G Doyle, Hugh Kearney, Charles A Steward, Nicholas J Lench, Anthony Rogers, Erin L Heinzen, Seamus McDonald, Joanna Fay, Austin Lacey, Alan Beausang, Jane Cryan, Francesca Brett, Hany El-Naggar, Peter Widdess-Walsh, Daniel Costello, Ronan Kilbride, Colin P Doherty, Kieron J Sweeney, Donncha F O'Brien, David C Henshall, Norman Delanty, Gianpiero L Cavalleri, Katherine A Benson
OBJECTIVE: The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug-resistant focal epilepsy. METHODS: Forty-two patients were recruited across three categories: (1) malformations of cortical development, (2) mesial temporal lobe epilepsy with hippocampal sclerosis, and (3) nonlesional focal epilepsy...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38491955/modification-of-brain-conductivity-in-human-focal-epilepsy-a-model-based-estimation-from-stereoelectroencephalography
#18
JOURNAL ARTICLE
Stanislas Lagarde, Julien Modolo, Maxime Yochum, Andres Carvallo, Alice Ballabeni, Didier Scavarda, Romain Carron, Nathalie Villeneuve, Fabrice Bartolomei, Fabrice Wendling
OBJECTIVE: We have developed a novel method for estimating brain tissue electrical conductivity using low-intensity pulse stereoelectroencephalography (SEEG) stimulation coupled with biophysical modeling. We evaluated the hypothesis that brain conductivity is correlated with the degree of epileptogenicity in patients with drug-resistant focal epilepsy. METHODS: We used bipolar low-intensity biphasic pulse stimulation (.2 mA) followed by a postprocessing pipeline for estimating brain conductivity...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38491947/diet-composition-and-sterilization-modifies-intestinal-microbiome-diversity-and-burden-of-theiler-s-virus-infection-induced-acute-seizures
#19
JOURNAL ARTICLE
Dannielle K Zierath, Stephanie Davidson, Jonathan Manoukian, Kevin M Knox, H Steve White, Stacey Meeker, Aaron Ericsson, Melissa Barker-Haliski
OBJECTIVE: Brain infection with Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6J mice can induce acquired epileptogenesis. Diet alters acute seizure incidence in TMEV-infected mice; yet it is unclear whether intestinal dysbiosis may also impact acute or chronic behavioral comorbidities. This study thus assessed the impact of diet formulation and sterilization on acute seizure presentation, gut microbiome composition, and epilepsy-related chronic behavioral comorbidities. METHODS: Baseline fecal samples were collected from male C57BL/6J mice (4- to 5-weeks-old; Jackson Labs) upon facility arrival...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38488289/why-did-my-seizures-start-now-influences-of-lesion-connectivity-and-genetic-etiology-on-age-at-seizure-onset-in-focal-epilepsy
#20
JOURNAL ARTICLE
Emma Macdonald-Laurs, Aaron E L Warren, Richard J Leventer, A Simon Harvey
OBJECTIVE: Patients with focal, lesional epilepsy present with seizures at variable ages. Larger lesion size and overlap with sensorimotor or default mode network (DMN) have been associated with younger age at seizure onset in cohorts with mixed types of focal cortical dysplasia (FCD). Here, we studied determinants of age at seizure onset in patients with bottom-of-sulcus dysplasia (BOSD), a discrete type of FCD with highly localized epileptogenicity. METHODS: Eighty-four patients (77% operated) with BOSD were studied...
March 15, 2024: Epilepsia
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