journal
https://read.qxmd.com/read/36453094/trends-in-cases-hospitalization-and-mortality-related-to-the-omicron-ba-4-ba-5-sub-variants-in-south-africa
#1
JOURNAL ARTICLE
Waasila Jassat, Salim S Abdool Karim, Lovelyn Ozougwu, Richard Welch, Caroline Mudara, Maureen Masha, Petro Rousseau, Milani Wolmarans, Anthony Selikow, Nevashan Govender, Sibongile Walaza, Anne von Gottberg, Nicole Wolter, Pedro Terrence Pisa, Ian Sanne, Sharlene Govender, Lucille Blumberg, Cheryl Cohen, Michelle J Groome
BACKGROUND: This study compared admission incidence risk across waves, and the risk of mortality in the Omicron BA.4/BA.5 wave, to the Omicron BA.1/BA.2 and Delta waves. METHODS: Data from South Africa's national hospital surveillance system, SARS-CoV-2 case linelist and Electronic Vaccine Data System were linked and analysed. Wave periods were defined when the country passed a weekly incidence of 30 cases/100,000 people. In-hospital case fatality ratios (CFR) in the Delta, Omicron BA...
December 1, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36450688/correction-to-leveraging-serosurveillance-and-postmortem-surveillance-to-quantify-the-impact-of-coronavirus-disease-2019-in-africa
#2
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36450653/correction-for-cid-115457-ciac284
#3
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36445792/predictors-of-covid-19-hospitalization-after-sotrovimab-in-hematologic-malignancy-patients-during-the-ba-1-omicron-surge
#4
JOURNAL ARTICLE
Judy Yan, Samantha N Steiger, Rich Kodama, Jerome Fender, Carrie Tan, Justin Laracy, Nina Cohen, Tracy McMillen, Krupa Jani, Elizabeth V Robilotti, N Esther Babady, Susan K Seo, Mini Kamboj
BACKGROUND: Sotrovimab is an anti-spike neutralization monoclonal antibody (mAB) developed to reduce the risk of Coronavirus Disease 2019 (COVID-19) progression and advancement to hospitalization in high-risk patients. Currently, there is limited research describing the association of sotrovimab treatment in patients with hematologic malignancies (HM) and the predictive factors of hospitalization. METHODS: We performed an observational study of 156 consecutive cancer patients who received sotrovimab at Memorial Sloan Kettering Cancer Center in New York City during the BA...
November 29, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36444485/use-of-statistical-process-control-methods-for-early-detection-of-healthcare-facility-associated-nontuberculous-mycobacterial-outbreaks-a-single-center-pilot-study
#5
JOURNAL ARTICLE
Arthur W Baker, Ahmed Maged, Salah Haridy, Jason E Stout, Jessica L Seidelman, Sarah S Lewis, Deverick J Anderson
BACKGROUND: Nontuberculous mycobacteria (NTM) are emerging pathogens increasingly implicated in healthcare facility-associated (HCFA) infections and outbreaks. We analyzed the performance of statistical process control (SPC) methods in detecting HCFA NTM outbreaks. METHODS: We retrospectively analyzed 3 NTM outbreaks that occurred from 2013-2016 at a tertiary care hospital. The outbreaks consisted of pulmonary Mycobacterium abscessus complex (MABC) acquisition, cardiac surgery-associated extrapulmonary MABC infection, and a bronchoscopy-associated pseudo-outbreak of Mycobacterium avium complex (MAC)...
November 29, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36433715/evaluation-of-the-united-states-definitions-for-covid-19-community-risk-levels
#6
JOURNAL ARTICLE
Sina Mokhtar, Alyssa S Parpia, Nathan C Lo, Martial L Ndeffo-Mbah
The United States CDC defines a county metric of COVID-19 Community Levels to inform public health measures. We find that the COVID-19 Community Levels vary frequently over time, which may not be optimal for decision making. Alternative metric formulations that do not compromise predictive ability are shown to reduce variability.
November 26, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36433685/impact-of-vaccination-with-scb-2019-covid-19-vaccine-on-transmission-of-sars-cov-2-infection-a-household-contact-study-in-the-philippines
#7
JOURNAL ARTICLE
Birkneh Tilahun Tadesse, Lulu Bravo, Florian Marks, Asma Binte Aziz, Young Ae You, Jonathan Sugimoto, Ping Li, Joyce Garcia, Frank Rockhold, Ralf Clemens
BACKGROUND: An exploratory household transmission study was nested in SPECTRA, the phase 2/3 efficacy study of the adjuvanted recombinant protein-based COVID-19 vaccine SCB-2019. We compared occurrence of confirmed COVID-19 infections between households and household contacts of infected SPECTRA placebo or SCB-2019 recipients. METHODS: SPECTRA participants at eight study sites in the Philippines who developed rRT-PCR-confirmed COVID-19 were contacted by a study team blinded to assignment of index cases to vaccine or placebo groups to enroll in this household transmission study...
November 26, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36433672/correction-to-risk-factors-for-mortality-among-children-younger-than-age-5-years-with-severe-diarrhea-in-low-and-middle-income-countries-findings-from-the-world-health-organization-coordinated-global-rotavirus-and-pediatric-diarrhea-surveillance-networks
#8
https://read.qxmd.com/read/36426590/reply-to-thornhill-et-al
#9
JOURNAL ARTICLE
Niko Vähäsarja, Bodil Lund, Aron Naimi-Akbar
No abstract text is available yet for this article.
November 25, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36424864/impact-of-undernutrition-on-tuberculosis-treatment-outcomes-in-india-a-multicenter-prospective-cohort-analysis
#10
JOURNAL ARTICLE
Pranay Sinha, Chinnaiyan Ponnuraja, Nikhil Gupte, Senbagavalli Prakash Babu, Samyra R Cox, Sonali Sarkar, Vidya Mave, Mandar Paradkar, Chelsie Cintron, S Govindarajan, Aarti Kinikar, Nadesan Priya, Sanjay Gaikwad, Balamugesh Thangakunam, Arutselvi Devarajan, Mythili Dhanasekaran, Jeffrey A Tornheim, Amita Gupta, Padmini Salgame, Devashyam Jesudas Christopher, Hardy Kornfeld, Vijay Viswanathan, Jerrold J Ellner, C Robert Horsburgh, Akshay N Gupte, Chandrasekaran Padmapriyadarsini, Natasha S Hochberg
BACKGROUND: Undernutrition is the leading risk factor for tuberculosis (TB) globally. Its impact on treatment outcomes is poorly defined. METHODS: We conducted a prospective cohort analysis of adults with drug-sensitive pulmonary TB at five sites in the Regional Prospective Observational Research on Tuberculosis (RePORT) India consortium (2015-2019). Using multivariable Poisson regression, we assessed independent associations between unfavorable outcomes and nutritional status based on body mass index (BMI) nutritional status at treatment initiation, BMI prior to TB disease, stunting, and stagnant or declining BMI after two months of TB treatment...
November 25, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36424854/linezolid-population-pharmacokinetics-to-improve-dosing-in-cardiosurgical-patients-factoring-a-new-drug-drug-interaction-pathway
#11
JOURNAL ARTICLE
Manjunath P Pai, Pier Giorgio Cojutti, Valentina Gerussi, Paola Della Siega, Carlo Tascini, Federico Pea
BACKGROUND: Linezolid-induced myelosuppression limits optimal therapy in cardiosurgical patients with deep-seated infections at current doses. METHODS: Adult patients who received a cardiac surgery intervention and linezolid for a documented or presumed serious Gram-positive infection were evaluated. Therapeutic monitoring data, dosing, concomitant medications, and other pertinent laboratory data were collected retrospectively. A population pharmacokinetic model was constructed to identify covariates and test potential drug-drug interactions that may account for interpatient variability...
November 25, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36419331/rectal-culture-based-versus-empirical-antibiotic-prophylaxis-to-prevent-infectious-complications-in-men-undergoing-transrectal-prostate-biopsy-a-randomized-non-blinded-multicenter-trial
#12
JOURNAL ARTICLE
Sofie Cm Tops, Eva Kolwijck, Evert L Koldewijn, Diederik M Somford, Filip Jm Delaere, Menno A van Leeuwen, Anthonius J Breeuwsma, Thijn F de Vocht, Hans Jhp Broos, Rob A Schipper, Martijn G Steffens, Steven Teerenstra, Marjolijn Ca Wegdam-Blans, Els de Brauwer, Wouter van den Bijllaardt, Alexander Cap Leenders, Jp Michiel Sedelaar, Heiman Fl Wertheim
BACKGROUND: An increase of infections after transrectal prostate biopsy (PB), related to an increasing number of patients with ciprofloxacin-resistant rectal flora, necessitates the exploration of alternatives for the traditionally standard used empirical prophylaxis with ciprofloxacin. We compared infectious complication rates after transrectal PB using empirical ciprofloxacin prophylaxis versus culture-based prophylaxis. METHODS: In this non-blinded, randomized trial, between April 4, 2018 to July 30, 2021, we enrolled 1538 patients from 11 Dutch hospitals undergoing transrectal PB...
November 24, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36419250/prevalence-distribution-and-characteristics-associated-with-possession-of-buprenorphine-waivers-among-infectious-diseases-physicians-in-the-united-states
#13
JOURNAL ARTICLE
Ayako Wendy Fujita, Nora Loughry, DeLante E Moore, Andrea E Carter, Sophia A Hussen, Hannah Cooper, Jonathan A Colasanti, Anandi N Sheth
BACKGROUND: Persons with opioid use disorder (OUD) may present with infectious complications from injection drug use, thus ID physicians are uniquely positioned to treat OUD. Buprenorphine is safe and effective for OUD but remains underutilized. The prevalence and geographic distribution of ID physicians who are waivered to prescribe buprenorphine are unknown. METHODS: This cross-sectional study merged data from several publicly available datasets from November 1, 2021 to January 15, 2022...
November 24, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36413595/antibiotic-prophylaxis-in-dentistry
#14
JOURNAL ARTICLE
Martin H Thornhill, Mark Dayer, Bernard D Prendergast, Peter Lockhart, Larry Baddour
No abstract text is available yet for this article.
November 22, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36411498/the-promise-and-peril-of-anti-sars-cov-2-monoclonal-antibodies
#15
JOURNAL ARTICLE
Jennifer M Davis, Jonathan Z Li
No abstract text is available yet for this article.
November 22, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36411267/azd7442-tixagevimab-cilgavimab-for-post-exposure-prophylaxis-of-symptomatic-covid-19
#16
JOURNAL ARTICLE
Myron J Levin, Andrew Ustianowski, Steven Thomas, Alison Templeton, Yuan Yuan, Seth Seegobin, Catherine F Houlihan, Ibrahim Menendez-Perez, Simon Pollett, Rosalinda H Arends, Rohini Beavon, Kanika Dey, Pedro Garbes, Elizabeth J Kelly, Gavin C K W Koh, Stefan Ivanov, Karen A Near, Audrey Sharbaugh, Katie Streicher, Menelas N Pangalos, Mark T Esser
BACKGROUND: We report primary results of a phase 3 trial of AZD7442 (tixagevimab/cilgavimab) for post-exposure prophylaxis to prevent symptomatic coronavirus disease 2019 (COVID-19). METHODS: Adults without prior SARS-CoV-2 infection or COVID-19 vaccination were enrolled within 8 days of exposure to a SARS-CoV-2-infected individual and randomized 2:1 to a single 300-mg AZD7442 dose (one 1.5-mL intramuscular injection each of tixagevimab and cilgavimab consecutively) or placebo...
November 22, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36409586/hiv-care-continuum-outcomes-after-transition-to-adult-care-among-a-prospective-cohort-of-youth-with-hiv-in-atlanta-georgia
#17
JOURNAL ARTICLE
Sophia A Hussen, Kamini Doraivelu, Madeleine H Goldstein, Neeta Shenvi, Kirk A Easley, Brian C Zanoni, Andrés Camacho-González, Carlos Del Río
BACKGROUND: Healthcare transition from pediatric to adult-oriented clinical settings is often viewed as a high-risk time for care disengagement. However, there is a paucity of prospective, longitudinal research documenting HIV care outcomes after HCT. METHODS: We conducted a prospective, observational cohort study of healthcare transition among youth enrolled at an HIV care center in Atlanta, Georgia. Pediatric clinic patients (average age 24 years) were enrolled up to three months prior to expected transition, and followed to determine linkage, retention, and viral suppression in adult care through electronic medical record abstractions at: baseline, 6-, 12-, 18- and 24-months...
November 21, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36401872/association-of-upper-respiratory-streptococcus-pneumoniae-colonization-with-sars-cov-2-infection-among-adults
#18
JOURNAL ARTICLE
Anna M Parker, Nicole Jackson, Shevya Awasthi, Hanna Kim, Tess Alwan, Anne L Wyllie, Alisha B Baldwin, Nicole B Brennick, Erica A Moehle, Petros Giannikopoulos, Katherine Kogut, Nina Holland, Ana Mora-Wyrobek, Brenda Eskenazi, Lee W Riley, Joseph A Lewnard
BACKGROUND: Streptococcus pneumoniae interacts with numerous viral respiratory pathogens in the upper airway. It is unclear whether similar interactions occur with SARS-CoV-2. METHODS: We collected saliva specimens from working-age adults receiving SARS-CoV-2 molecular testing at outpatient clinics and via mobile community-outreach testing between July and November 2020 in Monterey County, California. Following bacterial culture enrichment, we tested for pneumococci by quantitative polymerase chain reaction (qPCR) targeting the lytA and piaB genes, and measured associations with SARS-CoV-2 infection via conditional logistic regression...
November 19, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36398333/response-to-loewenthal-et-al
#19
JOURNAL ARTICLE
Scott Evans
No abstract text is available yet for this article.
November 18, 2022: Clinical Infectious Diseases
https://read.qxmd.com/read/36397680/correct-calculation-of-confidence-interval-for-proportion-of-superior-comparisons-between-desirability-of-outcome-ranking-scores
#20
JOURNAL ARTICLE
Mark R Loewenthal, Joshua S Davis, Michael Dymock
No abstract text is available yet for this article.
November 18, 2022: Clinical Infectious Diseases
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