Clinical Infectious Diseases

Hiroaki Baba, Hajime Kanamori
No abstract text is available yet for this article.
November 11, 2019: Clinical Infectious Diseases
Eelco Franz, Ovidiu Rotariu, Bruno S Lopes, James L Bono, Chad Laing, Victor Gannon, Angela H A M van Hoek, Ingrid Friesema, Nigel P French, Tessy George, Patrick J Biggs, Patricia Jaros, Marta Rivas, Isabel Chinen, Josefina Campos, Glen E Mellor, P Scott Chandry, Francisco Perez-Reche, Ken J Forbes, Norval J C Strachan
No abstract text is available yet for this article.
November 11, 2019: Clinical Infectious Diseases
Anne K Monroe, Lindsey P Happ, Nabil Rayeed, Yan Ma, Maria J Jaurretche, Arpi S Terzian, Kevin Trac, Michael A Horberg, Alan E Greenberg, Amanda D Castel
BACKGROUND: Using the results of a site assessment survey performed at clinics throughout Washington DC, we studied the impact of clinic-level factors on antiretroviral therapy (ART) initiation and viral suppression (VS) among people living with HIV (PLWH). METHODS: This was a retrospective analysis from the DC Cohort, an observational clinical cohort of PLWH from 2011-2018. We included data from PLWH not on ART and not virally suppressed at enrollment. Outcomes were ART initiation and VS (HIV RNA <200 copies/mL)...
November 8, 2019: Clinical Infectious Diseases
Laura B Balzer, Diane V Havlir, Moses R Kamya, Gabriel Chamie, Edwin D Charlebois, Tamara D Clark, Catherine A Koss, Dalsone Kwarisiima, James Ayieko, Norton Sang, Jane Kabami, Mucunguzi Atukunda, Vivek Jain, Carol S Camlin, Craig R Cohen, Elizabeth A Bukusi, Mark van der Laan, Maya L Petersen
BACKGROUND: In generalized epidemic settings, strategies are needed to prioritize individuals at higher risk of HIV acquisition for prevention services such as pre-exposure prophylaxis. We used population-level HIV testing data from rural Kenya and Uganda to construct HIV risk scores and assessed their ability to identify seroconversions. METHODS: Between 2013-2017, >75% of residents in 16 communities in the SEARCH Study tested annually for HIV. In this population, we evaluated three strategies for using demographic factors to predict the one-year risk of HIV seroconversion: (1) membership in ≥1 known "Risk Group" (e...
November 7, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Douglas S Krakower, Julia L Marcus
No abstract text is available yet for this article.
November 7, 2019: Clinical Infectious Diseases
Sam Tozay, William A Fischer, David A Wohl, Kayla Kilpatrick, Fei Zou, Edwina Reeves, Korto Pewu, Jean DeMarco, Amy James Loftis, Katie King, Donald Grant, John Schieffelin, Galakpai Gorvego, Henrietta Johnson, Tonia Conneh, Gerald Williams, Julie A E Nelson, David Hoover, Darrius McMillian, Carson Merenbloom, Darrell Hawks, Karine Dube, Jerry Brown
BACKGROUND: Cohort studies have reported a high prevalence of musculoskeletal, neurologic, auditory, and visual complications among Ebola Virus Disease (EVD) survivors; however, little is known about the host- and disease-related predictors of these symptoms and their etiological mechanisms. METHODS: The presence and patterns of eight cardinal symptoms that are most commonly reported following EVD survival were assessed in the 326 EVD survivors participating in the ongoing longitudinal Liberian EVD Survivor Study...
November 6, 2019: Clinical Infectious Diseases
Jun Li, Carl Armon, Frank J Palella, Richard M Novak, Douglas Ward, Stacey Purinton, Marcus Durham, Kate Buchacz
BACKGROUND: Although chlamydia (CT) and gonorrhea (GC) infections are increasing in the United States, there are limited data on their incidence, testing rates and associated risk factors among persons with HIV (PWH), including by anatomic site among men who have sex with men (MSM). METHODS: We analyzed 2007-2017 medical record data from HIV Outpatient Study participants in care at nine HIV clinics. We calculated CT (and GC) incidence and testing rates and assessed associations with sociodemographic and clinical factors using log-linear regression...
November 6, 2019: Clinical Infectious Diseases
Eleftheria Vasileiou, Aziz Sheikh, Chris C Butler, Chris Robertson, Kimberley Kavanagh, Tanya Englishby, Nazir I Lone, Beatrix von Wissmann, Jim McMenamin, Lewis D Ritchie, Jürgen Schwarze, Rory Gunson, Colin R Simpson
BACKGROUND: Influenza infection is an important trigger of asthma attacks. Influenza vaccination has the potential to reduce the incidence of influenza in people with asthma, but uptake remains persistently low, partially reflecting concerns about vaccine effectiveness (VE). METHODS: We conducted a test-negative design case-control study to estimate the effectiveness of influenza vaccine in children and adults with asthma in Scotland over six influenza seasons (2010/11 to 2015/16)...
November 5, 2019: Clinical Infectious Diseases
Gerrita van den Bunt, Ad C Fluit, Martin C J Bootsma, Engeline van Duijkeren, Jelle Scharringa, Wilfrid van Pelt, Marc J M Bonten
BACKGROUND: In the Netherlands the prevalence of intestinal Extended-spectrum Beta-lactamase producing Enterobacteriaceae (ESBL-E) carriage in community-dwelling subjects is ~5%. Little is known about the dynamics of ESBL-E carriage. METHODS: In a nation-wide population-based study (2014-2016) with 4,177 community-dwelling subjects, fecal samples from 656 subjects were also collected after one (T=1) and six (T=2) months. Growth of ESBL-E was quantified and whole genome sequence analysis performed...
November 5, 2019: Clinical Infectious Diseases
Wesley S Rogers, Lars F Westblade, Rosemary Soave, Stephen G Jenkins, Koen van Besien, Harjot K Singh, Thomas J Walsh, Catherine B Small, Tsiporah Shore, Carl V Crawford, Michael J Satlin
BACKGROUND: Diarrhea is common and associated with substantial morbidity among hematopoietic cell transplant (HCT) recipients, but the etiology is often not identified. Multiplexed PCR assays increase the detection of diarrheal pathogens, but the impact of this technology in this population has not been evaluated. METHODS: Our center replaced stool cultures and other conventional microbiological methods with the FilmArray® Gastrointestinal Panel (GI PCR) in June 2016...
November 5, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Jennifer L Saullo, Christopher R Polage
No abstract text is available yet for this article.
November 5, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
(no author information available yet)
No abstract text is available yet for this article.
November 4, 2019: Clinical Infectious Diseases
Bhumsuk Keam, Chang Kyung Kang, Kang Il Jun, Song Mi Moon, Koung Jin Suh, Dae-Won Lee, Chan-Young Ock, Miso Kim, Yunhee Choi, Yoojoo Lim, Kyung-Hun Lee, Se Hyun Kim, Tae Min Kim, Tae-Yong Kim, Do-Youn Oh, Dong-Wan Kim, Seock-Ah Im, Jong Seok Lee, Eu Suk Kim, Hong Bin Kim, Nam-Joong Kim, Yu Jung Kim, Wan Beom Park, Myoung-Don Oh
Among prospectively enrolled adult patients with cancer receiving immune checkpoint inhibitors (ICIs, n=46) or cytotoxic agents (n=90), seroprotection and seroconversion rates after seasonal quadrivalent influenza vaccinations were higher with ICI than with cytotoxic chemotherapy. These results supports administration of annual influenza vaccinations for patients with cancer that receive ICIs.
November 4, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Quentin Le Bastard, Pajau Vangay, Eric Batard, Dan Knights, Emmanuel Montassier
Little is known about the effect of human migration on gut microbiome antibiotic resistance gene (ARG) carriage. Using deep shotgun stool metagenomics analysis, we found a rapid increase in gut microbiome ARG richness and abundance in women from two independent ethnic groups relocating from Thailand to the United States.
November 4, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Edward Mpoza, Radha Rajasingham, Lillian Tugume, Joshua Rhein, Maria Sarah Nabaggala, Isaac Ssewanyana, Wilson Nyegenye, Grace Esther Kushemererwa, Vivienne Mulema, Julius Kalamya, Charles Kiyaga, Joseph Kabanda, Mina Ssali, David R Boulware, David B Meya
BACKGROUND: Detectable serum or plasma cryptococcal antigen (CrAg) precedes symptomatic cryptococcal meningitis. The World Health Organization (WHO) recommends CrAg screening for HIV infected people with CD4<100 cells/mcL initiating antiretroviral therapy (ART). However, an increasing proportion of cryptococcosis patients are now ART-experienced. Whether CrAg screening is cost-effective in those with virologic failure is unknown. METHODS: We retrospectively performed nationwide plasma CrAg testing among ART experienced Ugandan adults with virologic failure (≥1,000 copies/mL) using leftover plasma after viral load testing during September 2017-January 2018...
November 3, 2019: Clinical Infectious Diseases
Frederik Schaltz-Buchholzer, Morten Bjerregaard-Andersen, Christian Bjerregård Øland, Christian Golding, Elise Brenno Stjernholm, Ivan Monteiro, Peter Aaby, Christine Stabell Benn
BACKGROUND: Bacille Calmette-Guérin (BCG) vaccination remains a cornerstone against tuberculosis. Randomized controlled trials (RCTs) has demonstrated that BCG-Denmark lowers all-cause mortality, but a recent RCT found no effect of BCG-Russia. Observational studies indicate that the genetically divergent BCG strains have different effects. METHODS: Parallel-group, open-label RCT conducted at the National Hospital in Guinea-Bissau. Healthy neonates were randomized 1:1 to BCG-Denmark (2,851 randomized, 2,840 analyzed) versus BCG-Russia (2,845 randomized, 2,837 analyzed)...
November 3, 2019: Clinical Infectious Diseases
Sarah N Danchuk, Marcel A Behr
No abstract text is available yet for this article.
November 3, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Martin Hoenigl, Susan J Little, David Grelotti, Britt Skaathun, Gabriel A Wagner, Nadir Weibel, Jamila K Stockman, Davey M Smith
BACKGROUND: Technology has changed the way men-who-have-sex-with-men (MSM) seek sex. Over 60% of MSM in the US use the internet and/or smartphone-based geospatial networking apps to find sex partners. We correlated use of the most popular app (Grindr™) with sexual risk and prevention behavior among MSM. METHODS: A nested cohort study was conducted between September 2018 and June 2019 among MSM receiving community-based HIV and STI screening in central San Diego...
November 2, 2019: Clinical Infectious Diseases
Susannah L McKay, Angela Guo, Steven A Pergam, Kathleen Dooling
BACKGROUND: The primary reported risk factors for herpes zoster (HZ) are increasing age and immunodeficiency yet estimates of HZ risk by immunocompromising condition have not been well characterized. We undertook a systematic review of the literature to estimate HZ risk in five categories of immunocompromised patients. METHODS: We systematically reviewed studies examining risk of HZ and its complications in adult patients with hematopoietic cell transplants (HCT), cancer (hematologic and solid tumor), HIV, and solid organ transplant (SOT; kidney and other)...
November 2, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Evan B Cunningham, Behzad Hajarizadeh, Janaki Amin, Alain H Litwin, Edward Gane, Curtis Cooper, Karine Lacombe, Margaret Hellard, Phillip Read, Jeff Powis, Olav Dalgard, Julie Bruneau, Gail V Matthews, Jordan J Feld, John F Dillon, David Shaw, Philip Bruggmann, Brian Conway, Chris Fraser, Philippa Marks, Gregory J Dore, Jason Grebely
BACKGROUND: This study investigated treatment adherence and associated factors among people with recent injecting drug use or current opioid agonist therapy (OAT) and compared once-daily to twice-daily DAA therapy. METHODS: SIMPLIFY and D3FEAT are international, multicentre studies which recruited participants with recent injecting drug use (previous six months; SIMPLIFY, D3FEAT) or current OAT (D3FEAT) between March 2016 and February 2017 in eight countries. Participants received sofosbuvir/velpatasvir (once-daily; SIMPLIFY) or paritaprevir/ritonavir/ombitasvir, dasabuvir (twice-daily) ±ribavirin (D3FEAT) for 12 weeks administered in electronic blister-packs...
November 2, 2019: Clinical Infectious Diseases
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