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Behavioral and Neurological Effects of Edaravone and Noscapine in Albino Wistar Rats.
Experimental Aging Research 2023 August 25
OBJECTIVE: The purpose of the study was to explore Edaravone and Noscapine in anAlCl3-induced Alzheimer's disease (AD) model.
METHODS: Morris Water Maze (MWM), Novel Object Recognition (NOR), andY-maze tests with TNF-α, IL-1, IL-6, amyloid-β, CAT, SOD and MDAlevels were performed, followed by brain histology.
RESULTS: On the probe trial, the MWM demonstrated a decrease in escape latencyfollowed by an increase in the target quadrant. The NOR showeddiscrimination and recognition index scores and Y-maze, revealed arise in spontaneous alterations. TNF-α, IL-1, IL-6, amyloid-β, CATand MDA levels increased, while SOD levels dropped. The results werefound to be significant for combination full and half doses (*** p <0.001, ** p < 0.01). The treated group's histology ofbrain revealed mild neurodegeneration with hippocampal pyknoticnuclei.
CONCLUSIONS: Thus, Edaravone and Noscapine can be used for thetreatment of AD. .
METHODS: Morris Water Maze (MWM), Novel Object Recognition (NOR), andY-maze tests with TNF-α, IL-1, IL-6, amyloid-β, CAT, SOD and MDAlevels were performed, followed by brain histology.
RESULTS: On the probe trial, the MWM demonstrated a decrease in escape latencyfollowed by an increase in the target quadrant. The NOR showeddiscrimination and recognition index scores and Y-maze, revealed arise in spontaneous alterations. TNF-α, IL-1, IL-6, amyloid-β, CATand MDA levels increased, while SOD levels dropped. The results werefound to be significant for combination full and half doses (*** p <0.001, ** p < 0.01). The treated group's histology ofbrain revealed mild neurodegeneration with hippocampal pyknoticnuclei.
CONCLUSIONS: Thus, Edaravone and Noscapine can be used for thetreatment of AD. .
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