journal
https://read.qxmd.com/read/36437124/perioperative-ischaemic-brain-injury-and-plasma-neurofilament-light-a-secondary-analysis-of-two-prospective-cohort-studies
#1
JOURNAL ARTICLE
Jennifer Taylor, Laura Eisenmenger, Heidi Lindroth, James Booth, Rosaleena Mohanty, Veena Nair, Margaret Parker, David Kunkel, Cameron Rivera, Cameron Casey, Henrik Zetterberg, Kaj Blennow, Marko Mrkobrada, Philip J Devereaux, Robert A Pearce, Richard Lennertz, Vivek Prabhakaran, Robert D Sanders
BACKGROUND: Ischaemic brain infarction can occur without acute neurological symptoms (covert strokes) or with symptoms (overt strokes), both associated with poor health outcomes. We conducted a pilot study of the incidence of preoperative and postoperative (intraoperative or postoperative) covert strokes, and explored the relationship of postoperative ischaemic brain injury to blood levels of neurofilament light, a biomarker of neuronal damage. METHODS: We analysed 101 preoperative (within 2 weeks of surgery) and 58 postoperative research MRIs on postoperative days 2-9 from two prospective cohorts collected at the University of Wisconsin (NCT01980511 and NCT03124303)...
November 24, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36435668/airway-pressure-release-ventilation-a-survey-of-uk-practice
#2
LETTER
Louise Rose, Luigi Camporota, Gary H Mills, John Laffey, Gavin D Perkins, Manu Shankar-Hari, Tamas Szakmany, Danny McAuley
No abstract text is available yet for this article.
November 23, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36435667/tranexamic-acid-for-safer-surgery-does-the-evidence-support-preventative-use-comment-on-br-j-anaesth-2022-129-459-61
#3
LETTER
Alexander L Jones
No abstract text is available yet for this article.
November 23, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36435666/postoperative-anaemia-and-patient-centred-outcomes-after-major-abdominal-surgery-pathophysiology-versus-statistics-comment-on-br-j-anaesth-2022-129-346-54
#4
LETTER
Henrik Kehlet
No abstract text is available yet for this article.
November 23, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36435665/use-of-videolaryngoscopy-as-the-first-option-for-all-tracheal-intubations-not-so-fast-comment-on-br-j-anaesth-2022-129-624-63
#5
LETTER
Audrey De Jong, Yvan Pouzeratte, Thomas Sfara, Samir Jaber
No abstract text is available yet for this article.
November 23, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36428160/sex-specific-hypnotic-effects-of-the-neuroactive-steroid-3%C3%AE-5%C3%AE-17%C3%AE-3-hydroxyandrostane-17-carbonitrile-are-mediated-by-peripheral-metabolism-into-an-active-hypnotic-steroid
#6
JOURNAL ARTICLE
Francesca M Manzella, Omar H Cabrera, Davis Wilkey, Brier Fine-Raquet, Jelena Klawitter, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic
BACKGROUND: The novel synthetic neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) blocks T-type calcium channels but does not directly modulate neuronal γ-aminobutyric acid type A (GABAA ) currents like other anaesthetic neurosteroids. As 3β-OH has sex-specific hypnotic effects in adult rats, we studied the mechanism contributing to sex differences in its effects. METHODS: We used a combination of behavioural loss of righting reflex, neuroendocrine, pharmacokinetic, in vitro patch-clamp electrophysiology, and in vivo electrophysiological approaches in wild-type mice and in genetic knockouts of the CaV 3...
November 22, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36411131/association-between-maternal-cardiac-output-and-fetal-acidaemia-in-caesarean-delivery-under-spinal-anaesthesia-with-norepinephrine-infusion-a-retrospective-cohort-study
#7
LETTER
Yusuke Ikeda, Takayasu Sugiyama, Yuki Shiko, Azusa Nagai, Shohei Noguchi, Yohei Kawasaki, Yusuke Mazda
No abstract text is available yet for this article.
November 18, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36411130/electroencephalogram-based-prediction-and-detection-of-responsiveness-to-noxious-stimulation-in-critical-care-patients-a-retrospective-single-centre-analysis
#8
JOURNAL ARTICLE
Viktor Bublitz, Carlo Jurth, Matthias Kreuzer, Gregor Lichtner, Falk von Dincklage
BACKGROUND: Monitoring of pain and nociception in critical care patients unable to self-report pain remains a challenge, as clinical signs are neither sensitive nor specific. Available technical approaches are limited by various constraints. We investigated the electroencephalogram (EEG) for correlates that precede or coincide with behavioural nociceptive responses to noxious stimulation. METHODS: In this retrospective study, we analysed frontal EEG recordings of 64 critical care patients who were tracheally intubated and ventilated before, during, and after tracheal suctioning...
November 18, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36404140/epidemiological-methodological-and-statistical-characteristics-of-network-meta-analysis-in-anaesthesia-a-systematic-review
#9
REVIEW
Herman Sehmbi, Susanne Retter, Ushma J Shah, Derek Nguyen, Janet Martin, Vishal Uppal
BACKGROUND: Network meta-analyses (NMAs) combine direct and indirect estimates to provide mixed (or network) estimates of effect sizes. The scientific rigour of the conduct and reporting of anaesthesia NMAs is unknown. This review assessed the epidemiological, methodological, and statistical characteristics of anaesthesia NMAs. METHODS: We searched four databases for anaesthesia NMAs and developed a 64-item checklist to evaluate NMAs. For 29 binary items, we defined compliance as 'the ratio of NMAs that was awarded a 'yes' for that item, divided by the total number of NMAs...
November 17, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36402576/cognitive-deficits-after-general-anaesthesia-in-animal-models-a-scoping-review
#10
REVIEW
Ling Yi Guo, Lilia Kaustov, Connor T A Brenna, Vikas Patel, Cheng Zhang, Stephen Choi, Stephen Halpern, Dian-Shi Wang, Beverley A Orser
BACKGROUND: It remains controversial whether general anaesthetic drugs contribute to perioperative neurocognitive disorders in adult patients. Preclinical studies have generated conflicting results, likely because of differing animal models, study protocols, and measured outcomes. This scoping review of preclinical studies addressed the question: 'Do general anaesthetic drugs cause cognitive deficits in adult animals that persist after the drugs have been eliminated from the brain?' METHODS: Reports of preclinical studies in the MEDLINE database published from 1953 to 2021 were examined...
November 16, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36396483/neuroimaging-reveals-a-potential-brain-based-pre-existing-mechanism-that-confers-vulnerability-to-development-of-chronic-painful-chemotherapy-induced-peripheral-neuropathy
#11
JOURNAL ARTICLE
Marta Seretny, Liana Romaniuk, Heather Whalley, Kim Sladdin, Stephen Lawrie, Catherine Elizabeth Warnaby, Neil Roberts, Lesley Colvin, Irene Tracey, Marie Fallon
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition impacting 30% of cancer survivors. This study is the first to explore whether a brain-based vulnerability to chronic sensory CIPN exists. METHODS: This prospective, multicentre cohort study recruited from three sites across Scotland. Brain functional MRI (fMRI) scans (3 Tesla) were carried out on chemotherapy naïve patients at a single fMRI centre in Edinburgh, Scotland. Nociceptive stimuli (with a 256 mN monofilament) were administered during the fMRI...
November 14, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36376100/the-evolution-of-the-british-journal-of-anaesthesia-the-first-100-years
#12
EDITORIAL
William Fitch, Graham Smith, Jennifer M Hunter, Charles S Reilly, Ravi P Mahajan, Hugh C Hemmings
At this centenary of the British Journal of Anaesthesia (BJA) in 2023, six of its 12 editors/editors-in-chief detail developments over the decades that have led to the BJA becoming a high-impact international scientific journal. As a charity, the BJA supports academic research and training in anaesthesia, critical care, and pain medicine including funding of research grants and postgraduate education. Building on this foundation, the BJA continues to innovate as it aims to become fully electronic, expand into open access publishing, and increase the diversity of its editorial board...
November 12, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36376101/persistent-opioid-use-after-gender-affirmation-surgery
#13
LETTER
Stavros G Memtsoudis, Haoyan Zhong, Jiabin Liu, Jashvant Poeran, Crispiana Cozowicz, Brian Sites
No abstract text is available yet for this article.
November 11, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36376099/determination-of-reference-ranges-for-the-clotpro%C3%A2-thromboelastometry-device-in-paediatric-patients
#14
JOURNAL ARTICLE
Katarina Laukova, Veronika Petrikova, Lubomira Poloniova, Lucia Babulicova, Ladislava Wsolova, Thorsten Haas
BACKGROUND: A new thromboelastometry analyser (ClotPro®) was developed with advanced diagnostics. The reference ranges of ClotPro® in children ages 0-16 yr have not been reported. METHODS: In this prospective study, venous blood samples from 321 patients were obtained from children undergoing elective surgery after induction of anaesthesia. Reference ranges were defined by calculating the 2.5% and 97.5% percentiles for each age group (0-3 months, 4-12 months, 13-24 months, 2-5 yr, 6-10 yr, and 11-16 yr)...
November 11, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36371258/associations-between-postpartum-pain-type-pain-intensity-and-opioid-use-in-patients-with-and-without-opioid-use-disorder
#15
JOURNAL ARTICLE
Grace Lim, Kelsea R LaSorda, Elizabeth Krans, Bedda L Rosario, Cynthia A Wong, Steve Caritis
BACKGROUND: Pain is a multidimensional construct. The purpose of this cross-sectional, single-centre study was to evaluate the relationship between postpartum pain type with pain intensity and opioid use in people with and without opioid use disorder (OUD). METHODS: Postpartum pain type was coded from McGill Pain Questionnaire and Patient-Reported Outcome Measurement Information System (PROMIS) inventories in people with or without OUD after childbirth in a 4-month period...
November 9, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36371257/factor-xiii-levels-clot-strength-and-impact-of-fibrinogen-concentrate-in-infants-undergoing-cardiopulmonary-bypass-a-mechanistic-sub-study-of-the-fibcon-trial
#16
JOURNAL ARTICLE
Kristina Siemens, Beverley J Hunt, Kiran Parmar, Dan Taylor, Caner Salih, Shane M Tibby
BACKGROUND: Acquired factor XIII (FXIII) deficiency after major surgery can increase postoperative bleeding. We evaluated FXIII contribution to clot strength and the effect of fibrinogen concentrate administration on FXIII activity in infants undergoing cardiac surgery using cardiopulmonary bypass. METHODS: We conducted a prospectively planned, mechanistic sub-study, nested within the Fibrinogen Concentrate Supplementation in the Management of Bleeding During Paediatric Cardiopulmonary Bypass: A Phase 1B/2A, Open-Label Dose Escalation Study (FIBCON) trial, which investigated fibrinogen concentrate supplementation during cardiopulmonary bypass (ISRCTN: 50553029) in 111 infants (median age 6...
November 9, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36369017/intraoperative-central-venous-pressure-and-acute-kidney-injury-incidence-in-patients-with-cardiac-arrest-comment-on-brit-j-anaesth-2022-128-785-95
#17
LETTER
Xiaolu Shao, Jianping Jiang
No abstract text is available yet for this article.
November 8, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36369016/flawed-futile-and-fabricated-features-that-limit-confidence-in-clinical-research-in-pain-and-anaesthesia-a-narrative-review
#18
REVIEW
Andrew Moore, Emma Fisher, Christopher Eccleston
The randomised controlled trial is the foundation of clinical research; yet there is concern that many trials have flaws in design, conduct, and reporting that undermine trustworthiness. Common flaws in trials include high risk of bias, small size, outcomes irrelevant to clinical care and patient's experience, and inability to detect efficacy even if present. These flaws carry forward into systematic reviews, which can confer the label of 'high-quality evidence' on inadequate data. Trials can be futile because their flaws mean that they cannot deliver any meaningful result in that different results in a small number of patients would be sufficient to change conclusions...
November 8, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36347723/plasma-exosomes-generated-by-ischaemic-preconditioning-are-cardioprotective-in-a-rat-heart-failure-model
#19
JOURNAL ARTICLE
Zhaofei Luo, Xudong Hu, Chao Wu, Jinzhong Chan, Zhong Liu, Chengxiao Guo, Rui Zhu, Li Zhang, Ye Zhang, Shiyun Jin, Shufang He
BACKGROUND: Exosomes released into the plasma after brief cardiac ischaemia mediate subsequent cardioprotection. Whether donor exosomes can provide cardioprotection to recipients with chronic heart failure, which confers the highest perioperative risk, is unknown. We examined whether ischaemic preconditioning (IPC)-induced plasma exosomes exerted cardioprotection after their transfer from normal donors to post-infarcted failing hearts. METHODS: Plasma exosomes were obtained from adult rats after IPC or sham...
November 5, 2022: British Journal of Anaesthesia
https://read.qxmd.com/read/36344330/presumption-of-insensibility-during-general-anaesthesia
#20
EDITORIAL
Andrew E Hudson
Whilst the general presumption of the public is that general anaesthesia prevents awareness of any sensory stimuli, Lennertz and colleagues have shown in this issue of the British Journal of Anaesthesia that 11% of young adults were able to respond to auditory commands when neuromuscular blocking drugs were prevented from reaching one arm using the isolated forearm technique. This occurred with anaesthetic regimens that followed usual clinical practice in each of the 10 countries that enrolled patients, and it was significantly more common in women than in men...
November 4, 2022: British Journal of Anaesthesia
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