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British Journal of Anaesthesia

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https://read.qxmd.com/read/31300165/withholding-antiplatelet-therapy-before-noncardiac-surgery-might-increase-the-risk-of-major-adverse-cardiovascular-events-numbers-often-hide-the-truth-comment-on-bja-2019-122-170-179
#1
LETTER
Habib M R Karim, Pradipta Bhakta, Michele C Vassallo
No abstract text is available yet for this article.
July 9, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31300164/benefits-of-a-home-catheter-programme-will-the-regional-anaesthetist-please-stand-up
#2
LETTER
Rakesh V Sondekoppam, Vivian H Y Ip, Timur Özelsel
No abstract text is available yet for this article.
July 9, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31280889/cerebral-autoregulation-with-age-comes-wisdom
#3
LETTER
Rogier V Immink, Nicolaas H Sperna Weiland, Rokus E C van den Dool, Björn J P van der Ster, Markus W Hollmann
No abstract text is available yet for this article.
July 4, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31279479/paradox-of-age-older-patients-receive-higher-age-adjusted-minimum-alveolar-concentration-fractions-of-volatile-anaesthetics-yet-display-higher-bispectral-index-values
#4
Katherine Ni, Mary Cooter, Dhanesh K Gupta, Jake Thomas, Thomas J Hopkins, Timothy E Miller, Michael L James, Miklos D Kertai, Miles Berger
BACKGROUND: Minimum alveolar concentration (MAC) and MAC-awake decrease with age. We hypothesised that, in clinical practice, (i) end-tidal MAC fraction in older patients would decline by less than the predicted age-dependent MAC decrease (i.e. older patients would receive relatively excessive anaesthetic concentrations), and (ii) bispectral index (BIS) values would therefore be lower in older patients. METHODS: We examined the relationship between end-tidal MAC fraction, BIS values, and age in 4699 patients > 30 yr in age at a single centre using unadjusted local regression (locally estimated scatterplot smoothing), Spearman's correlation, stratification, and robust univariable and multivariable linear regression...
July 3, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31277837/transient-subcortical-functional-connectivity-upon-emergence-from-propofol-sedation-in-human-male-volunteers-evidence-for-active-emergence
#5
Tommer Nir, Ayelet Or-Borichev, Evgeny Izraitel, Talma Hendler, Yulia Lerner, Idit Matot
BACKGROUND: Emergence from sedation entails rapid increase in the levels of both awareness and wakefulness, the two axes of consciousness. Functional MRI (fMRI) studies of emergence from sedation often focus on the recovery period, with no description of the moment of emergence. We hypothesised that by focusing on the moment of emergence, novel insights, primarily about subcortical activity and increased wakefulness, will be gained. METHODS: We conducted a resting state fMRI analysis of 17 male subjects (20-40 yr old) gradually entering into and emerging from deep sedation (average computed propofol concentrations of 2...
July 2, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31277836/multimodal-monitoring-approach-the-key-to-safe-performance-of-peripheral-nerve-blocks
#6
LETTER
Vivian H Y Ip, Timur J P Özelsel, Rakesh V Sondekoppam, Ban C H Tsui
No abstract text is available yet for this article.
July 2, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31262508/osteopontin-mediates-necroptosis-in-lung-injury-after-transplantation-of-ischaemic-renal-allografts-in-rats
#7
Hailin Zhao, Qian Chen, Han Huang, Ka C Suen, Azeem Alam, Jiang Cui, Sarah Ciechanowicz, Jiaolin Ning, Kaizhi Lu, Masao Takata, Jianteng Gu, Daqing Ma
BACKGROUND: Respiratory complications after surgery are associated with morbidity and mortality. Acute lung injury can result from the systemic inflammatory response after acute kidney injury. The mechanisms behind this remote injury are not fully understood. In this study, a renal transplantation model was used to investigate remote lung injury and the underlying molecular mechanisms, especially the role of osteopontin (OPN). METHODS: In vitro, human lung epithelial cell line (A549) and monocyte/macrophage cell line (U937) were challenged with tumour necrosis factor-alpha (TNF-α) in combination with OPN...
June 28, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31262507/delayed-recovery-from-neuromuscular-block-after-sugammadex-in-a-patient-with-parkinson-s-disease
#8
LETTER
B Altıparmak, M Korkmaz Toker, Ai Uysal, A Pınarbaşı, S Gümüş Demirbilek
No abstract text is available yet for this article.
June 28, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31256917/finding-the-starter-motor-for-the-engine-of-consciousness
#9
EDITORIAL
Jamie Sleigh, Catherine E Warnaby
No abstract text is available yet for this article.
June 27, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31256916/external-validation-of-the-revised-cardiac-risk-index-and-national-surgical-quality-improvement-program-myocardial-infarction-and-cardiac-arrest-calculator-in-noncardiac-vascular-surgery
#10
J Fronczek, K Polok, P J Devereaux, J Górka, R A Archbold, B Biccard, E Duceppe, Y Le Manach, D I Sessler, M Duchińska, W Szczeklik
BACKGROUND: The National Surgical Quality Improvement Program Myocardial Infarction & Cardiac Arrest (NSQIP MICA) calculator and the Revised Cardiac Risk Index (RCRI) were derived using currently outdated methods of diagnosing perioperative myocardial infarctions. We tested the external validity of these tools in a setting of a systematic perioperative cardiac biomarker measurement. METHODS: Analysis of routinely collected data nested in the Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study...
June 27, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31255291/influence-of-perioperative-anaesthetic-and-analgesic-interventions-on-oncological-outcomes-a-narrative-review
#11
REVIEW
T Wall, A Sherwin, D Ma, D J Buggy
Surgery is an important treatment modality for the majority of solid organ cancers. Unfortunately, cancer recurrence following surgery of curative intent is common, and typically results in refractory disease and patient death. Surgery and other perioperative interventions induce a biological state conducive to the survival and growth of residual cancer cells released from the primary tumour intraoperatively, which may influence the risk of a subsequent metastatic disease. Evidence is accumulating that anaesthetic and analgesic interventions could affect many of these pathophysiological processes, influencing risk of cancer recurrence in either a beneficial or detrimental way...
June 26, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31255290/feasibility-of-closed-loop-titration-of-norepinephrine-infusion-in-patients-undergoing-moderate-and-high-risk-surgery
#12
Alexandre Joosten, Brenton Alexander, Jacques Duranteau, Fabio Silvio Taccone, Jacques Creteur, Jean-Louis Vincent, Maxime Cannesson, Joseph Rinehart
BACKGROUND: Vasopressor agents are used to prevent intraoperative hypotension and ensure adequate perfusion. Vasopressors are usually administered as intermittent boluses or manually adjusted infusions, but this practice requires considerable time and attention. We have developed a closed-loop vasopressor (CLV) controller to correct hypotension more efficiently. Here, we conducted a proof-of-concept study to assess the feasibility and performance of CLV control in surgical patients. METHODS: Twenty patients scheduled for elective surgical procedures were included in this study...
June 26, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31255289/validity-and-reliability-of-metrics-for-translation-of-regional-anaesthesia-performance-from-cadavers-to-patients
#13
Graeme McLeod, Mel McKendrick, Alasdair Taylor, Joanna Lynch, Jean Ker, Amy Sadler, Jayne Halcrow, Gary McKendrick, Ayman Mustafa, Jonathan Seeley, Pavan Raju, George Corner
BACKGROUND: Our goal is to develop metrics that quantify the translation of performance from cadavers to patients. Our primary objective was to develop steps and error checklists from a Delphi questionnaire. Our second objective was to show that our test scores were valid and reliable. METHODS: Sixteen UK experts identified 15 steps conducive to good performance and 15 errors to be avoided during interscalene block on the soft-embalmed cadaver and patients. Thereafter, six experts and six novices were trained, and then tested...
June 26, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31253357/mitochondrial-calcium-uniporter-contributes-to-morphine-tolerance-through-pcreb-and-cpeb1-in-rat-spinal-cord-dorsal-horn
#14
K Takahashi, H Yi, J Gu, D Ikegami, S Liu, T Iida, Y Kashiwagi, C Dong, T Kunisawa, S Hao
BACKGROUND: The long-term use of opioid analgesics is limited by the development of unwanted side-effects, such as tolerance. The molecular mechanisms of morphine anti-nociceptive tolerance are still unclear. The mitochondrial calcium uniporter (MCU) is involved in painful hyperalgesia, but the role of MCU in morphine tolerance has not been uncharacterised. METHODS: Rats received intrathecal injection of morphine for 7 days to induce morphine tolerance. The mechanical withdrawal threshold was measured using von Frey filaments, and thermal latency using the hotplate test...
June 25, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31248646/organophosphorus-nerve-agent-poisoning-managing-the-poisoned-patient
#15
REVIEW
Elspeth J Hulse, James D Haslam, Stevan R Emmett, Tom Woolley
Organophosphorus (OP) nerve agent poisoning made the headlines in 2018 with the nerve agent 'Novichok' poisonings in Salisbury, England. This event highlighted a gap in the knowledge of most clinicians in the UK. In response, this special article aims to enlighten and signpost anaesthetists and intensivists towards the general management of OP nerve agent poisoned patients. Drawing on a broad range of sources, we will discuss what OP nerve agents are, how they work, and how to recognise and treat OP nerve agent poisoning...
June 24, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31248645/severe-acute-pain-and-persistent-post-surgical-pain-in-orthopaedic-trauma-patients-a-cohort-study
#16
Carla Edgley, Malcolm Hogg, Anurika De Silva, Sabine Braat, Andrew Bucknill, Kate Leslie
BACKGROUND: We conducted a cohort study of adult patients presenting for orthopaedic trauma surgery at a statewide trauma centre, with the aims of determining (i) the incidence and risk factors for severe acute pain in the PACU, and (ii) the incidence and risk factors for persistent post-surgical pain at 3 months. METHODS: Data were collected before operation, in the PACU, 72 h after surgery and 3 months after surgery, and included numerical rating scale (NRS) scores for pain, and modified Brief Pain Inventory-Short Form, Kessler Psychological Distress Scale, World Health Organization Disability Assessment Schedule, and Pain Catastrophizing Scale scores...
June 24, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31248644/post-discharge-impact-and-cost-consequence-analysis-of-prehabilitation-in-high-risk-patients-undergoing-major-abdominal-surgery-secondary-results-from-a-randomised-controlled-trial
#17
A Barberan-Garcia, M Ubre, N Pascual-Argente, R Risco, J Faner, J Balust, A M Lacy, J Puig-Junoy, J Roca, G Martinez-Palli
BACKGROUND: Prehabilitation may reduce postoperative complications, but sustainability of its health benefits and impact on costs needs further evaluation. Our aim was to assess the midterm clinical impact and costs from a hospital perspective of an endurance-exercise-training-based prehabilitation programme in high-risk patients undergoing major digestive surgery. METHODS: A cost-consequence analysis was performed using secondary data from a randomised, blinded clinical trial...
June 24, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31248643/defining-perioperative-neurocognitive-disorders-still-more-to-clarify
#18
LETTER
Elif A Çizmeci, Arjen J C Slooter
No abstract text is available yet for this article.
June 24, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31248642/anaesthetists-and-syringe-hygiene-getting-to-the-pointy-end
#19
LETTER
Lloyd E Kwanten
No abstract text is available yet for this article.
June 24, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31248641/perioperative-beta-adrenergic-antagonism-panacea-or-poison
#20
EDITORIAL
W Scott Beattie, Homer Yang
No abstract text is available yet for this article.
June 24, 2019: British Journal of Anaesthesia
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