journal
https://read.qxmd.com/read/36967283/anti-high-mobility-group-box-1-treatment-strategies-improve-trauma-induced-coagulopathy-in-a-mouse-model-of-trauma-and-shock
#1
JOURNAL ARTICLE
Pieter H Sloos, M Adrie W Maas, Joost C M Meijers, Rienk Nieuwland, Joris J T H Roelofs, Nicole P Juffermans, Derek J B Kleinveld
BACKGROUND: Trauma-induced coagulopathy is associated with platelet dysfunction and contributes to early mortality after traumatic injury. Plasma concentrations of the damage molecule high-mobility group box-1 (HMGB-1) increase after trauma, which may contribute to platelet dysfunction. We hypothesised that inhibition of HMGB-1 with a monoclonal antibody (mAb) or with recombinant thrombomodulin (rTM) improves trauma-induced coagulopathy in a murine model of trauma and shock. METHODS: Male 129S2/SvPasOrlRJ mice were anaesthetised, mechanically ventilated, and randomised into five groups: (i) ventilation control (VENT), (ii) trauma/shock (TS), (iii) TS+anti-HMGB-1 mAb (TS+AB), (iv) TS+rTM (TS+TM), and (v) TS+anti-HMGB-1 mAb+rTM (TS+COMBI)...
March 24, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36967282/breathe-squeeze-pharmacodynamics-of-a-stimulus-free-behavioural-paradigm-to-track-conscious-states-during-sedation-%C3%A2
#2
JOURNAL ARTICLE
Christian S Guay, Darren Hight, Gaurang Gupta, MohammadMehdi Kafashan, Anhthi H Luong, Michael S Avidan, Emery N Brown, Ben Julian A Palanca
BACKGROUND: Conscious states are typically inferred through responses to auditory tasks and noxious stimulation. We report the use of a stimulus-free behavioural paradigm to track state transitions in responsiveness during dexmedetomidine sedation. We hypothesised that estimated dexmedetomidine effect-site (Ce) concentrations would be higher at loss of responsiveness (LOR) compared with return of responsiveness (ROR), and both would be lower than comparable studies that used stimulus-based assessments...
March 24, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36967281/pholcodine-exposure-increases-the-risk-of-perioperative-anaphylaxis-to-neuromuscular-blocking-agents-the-alpho-case-control-study
#3
JOURNAL ARTICLE
Paul Michel Mertes, Nadine Petitpain, Charles Tacquard, Marion Delpuech, Cédric Baumann, Jean Marc Malinovsky, Dan Longrois, Aurélie Gouel-Cheron, Diane Le Quang, Pascal Demoly, Jean Louis Guéant, Pierre Gillet
BACKGROUND: Neuromuscular blocking agents (NMBAs) are among the leading cause of perioperative anaphylaxis, and most of these reactions are IgE mediated. Allergic sensitisation induced by environmental exposure to other quaternary ammonium-containing compounds, such as pholcodine, has been suggested. The aim of this study was to assess the relationship between pholcodine exposure and NMBA-related anaphylaxis. METHODS: ALPHO was a multicentre case-control study, comparing pholcodine exposure within a year before anaesthesia between patients with NMBA-related perioperative anaphylaxis (cases) and control patients with uneventful anaesthesia in France...
March 24, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36967280/clinical-hypnosis-implications-in-anaesthesia-and-perioperative-care
#4
EDITORIAL
Allan M Cyna, David W Hewson, Jonathan G Hardman
A randomised trial published in the British Journal of Anaesthesia describes hypnosis compared with general anaesthesia in 60 children undergoing superficial surgery. We describe a definition of clinical hypnosis; the goals and conduct of hypnotic communication; and its potential as both an adjunct and, in suitable cases, alternative to traditional pharmacological anaesthesia.
March 24, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36967279/the-japanese-epidemiologic-study-for-perioperative-anaphylaxis-a-prospective-nationwide-study-clinical-signs-severity-and-therapeutic-agents
#5
JOURNAL ARTICLE
Yuki Suigiyama, Tomonori Takazawa, Natsuko Watanabe, Kiyoko Bito, Tetsuhiro Fujiyoshi, Shinsuke Hamaguchi, Takashi Haraguchi, Tatsuo Horiuchi, Yoshinori Kamiya, Noboru Maruyama, Hitoshi Masumo, Harumasa Nakazawa, Kazuhiro Nagumo, Masaki Orihara, Jun Sato, Kenichi Sekimoto, Kenichiro Takahashi, Mutsumi Uchiyama, Kazunobu Takahashi, Masao Yamaguchi, Mikito Kawamata
BACKGROUND: Diagnosis of perioperative anaphylaxis is difficult because of its non-specific and variable signs and symptoms. Therapeutic agents used to treat anaphylaxis and anaesthesiologist responses also vary depending on the case, which might affect outcomes; however, only a few studies have focused on these factors. METHODS: This prospective study of perioperative anaphylaxis, a part of the Japanese Epidemiologic Study for Perioperative Anaphylaxis, investigated the clinical signs, its severity, therapeutic drugs, epinephrine administration, and anaesthesiologist responses in cases of perioperative anaphylaxis to assess trends and variability...
March 24, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36966023/sensory-block-duration-after-spinal-anaesthesia-supplemented-with-intravenous-dexamethasone-a-randomised-controlled-double-blinded-trial
#6
JOURNAL ARTICLE
Alexis Bikfalvi, Gregory Hofmann, Ahmed Bashawyah, Jean-Benoit Rossel, Erin Gonvers, Eric Albrecht
BACKGROUND: Intravenous dexamethasone prolongs duration of analgesia or sensory block after injection of local anaesthetics close to peripheral nerves by an average of 8 h. Uncertainty remains on the potential increase in the duration of sensory block after spinal anaesthesia. The objective of this randomised controlled double-blinded trial was to investigate whether dexamethasone i.v. prolongs the sensory block of spinal anaesthesia with bupivacaine when compared with a control group...
March 23, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36966022/difficult-airway-management-in-children-with-trisomy-18-a-retrospective-single-centre-study-of-incidence-outcomes-and-complications
#7
LETTER
Wenyu Bai, Thomas Klumpner, Xinyi Zhao, Graciela Mentz, Glenn Green, Lori Q Riegger, Shobha Malviya, Sydney E S Brown
No abstract text is available yet for this article.
March 23, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36964012/quality-of-recovery-after-pericapsular-nerve-group-peng-block-for-primary-total-hip-arthroplasty-under-spinal-anaesthesia-a-randomised-controlled-observer-blinded-trial
#8
JOURNAL ARTICLE
Promil Kukreja, Vishal Uppal, Alexander M Kofskey, Joel Feinstein, Theresa Northern, Camille Davis, Charity J Morgan, Hari Kalagara
BACKGROUND: The pericapsular nerve group (PENG) block is a novel regional anaesthesia technique that has been proposed as an effective motor-sparing block for total hip arthroplasty. Recent randomised studies show conflicting results regarding the analgesic efficacy of the PENG block for total hip arthroplasty. METHODS: We conducted a randomised controlled observer-blinded single-centre superiority trial comparing the efficacy of the PENG block with no block for patients undergoing primary total hip arthroplasty under spinal anaesthesia...
March 22, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36941172/efficiency-of-inhaled-anaesthetic-recapture-in-clinical-practice-comment-on-br-j-anaesth-2022-129-e79-e81
#9
LETTER
Jason Gandhi, Ian Baxter
No abstract text is available yet for this article.
March 18, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36935308/influence-of-additional-personal-protective-equipment-on-team-performance-in-simulation-based-emergency-scenarios-a-randomised-controlled-trial
#10
LETTER
Metoděj Renza, David Peřan, Roman Sýkora, Michael Stern, Václav Zvoníček, Petr Waldauf, František Duška
No abstract text is available yet for this article.
March 17, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36935307/perioperative-approach-for-patients-taking-oral-isotretinoin
#11
LETTER
Staffan Holbeck
No abstract text is available yet for this article.
March 17, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36933955/use-of-computer-aided-design-and-3d-printing-for-airway-management-in-paediatric-patients-with-a-cleft-facial-defect-a-pilot-study
#12
LETTER
Michaela Richtrova, Olga Koskova, Petr Marcian, Marek Joukal, Tereza Musilova, Martin Janku, Dominik Fabian, Dominika Matyskova, Petr Stourac
No abstract text is available yet for this article.
March 16, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36931963/spin-and-fragility-in-anaesthesia-studies-when-sirens-sing-into-anaesthetists-ears
#13
EDITORIAL
Marcelo Gama de Abreu, Marcus J Schultz, Ary Serpa Neto
Spin and fragility are common in randomised controlled trials published in anaesthesia journals. Staying with the facts and addressing only the primary endpoint in the conclusion of clinical research reports might help reduce spin. Routinely reporting the fragility index, in turn, could deliver information about robustness, enhancing the transparency of positive dichotomous results. It is in the best interest of clinical research that authors, reviewers, and journals come together to reduce spin and address the fragility of randomised controlled trials...
March 15, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36931962/randomised-trials-to-improve-haemostasis-management-for-postpartum-haemorrhage-comment-on-br-j-anaesth-2023-130-165-74
#14
LETTER
Amir L Butt, Sharon Bouvette, Kaitlyn Kulesus, Kenichi A Tanaka
No abstract text is available yet for this article.
March 15, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36931961/sevoflurane-dose-and-postoperative-delirium-comment-on-br-j-anaesth-2023-130-e289-97
#15
LETTER
Robert Davidson, Matthew K Palethorpe
No abstract text is available yet for this article.
March 15, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36925330/norepinephrine-versus-phenylephrine-for-treating-hypotension-during-general-anaesthesia-in-adult-patients-undergoing-major-noncardiac-surgery-a-multicentre-open-label-cluster-randomised-crossover-feasibility-and-pilot-trial
#16
JOURNAL ARTICLE
Matthieu Legrand, Rishi Kothari, Nicholas Fong, Nandini Palaniappa, David Boldt, Lee-Lynn Chen, Philip Kurien, Eilon Gabel, Jillene Sturgess-DaPrato, Michael O Harhay, Romain Pirracchio, Michael P Bokoch
BACKGROUND: Intraoperative hypotension is associated with postoperative complications. The use of vasopressors is often required to correct hypotension but the best vasopressor is unknown. METHODS: A multicentre, cluster-randomised, crossover, feasibility and pilot trial was conducted across five hospitals in California. Phenylephrine (PE) vs norepinephrine (NE) infusion as the first-line vasopressor in patients under general anaesthesia alternated monthly at each hospital for 6 months...
March 14, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36925329/use-of-rocuronium-and-sugammadex-for-video-assisted-thoracoscopic-surgery-is-associated-with-reduced-duration-of-chest-tube-drainage-comment-on-br-j-anaesth-2023-130-e119-27
#17
LETTER
https://read.qxmd.com/read/36925328/thromboelastometry-guided-treatment-algorithm-in-postpartum-haemorrhage-comment-on-br-j-anaesth-2023-130-165-74
#18
LETTER
Nicholas Di Mascio, Don Walsh, Nikki Higgins
No abstract text is available yet for this article.
March 14, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36922267/william-brooke-o-shaughnessy-an-irishman-who-introduced-anaesthesia-to-india-and-brought-eastern-medicine-to-britain
#19
LETTER
Natalie R Lenggenhager-Krakoski, Pradipta Bhakta, Mohanchandra Mandal, Dominic Harmon, Brian O'Brien
No abstract text is available yet for this article.
March 13, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36922266/electroencephalographic-delta-and-alpha-oscillations-reveal-phase-amplitude-coupling-in-paediatric-patients-undergoing-sevoflurane-based-general-anaesthesia
#20
JOURNAL ARTICLE
Luai Zakaria, Adela Desowska, Charles B Berde, Laura Cornelissen
BACKGROUND: Sevoflurane-induced anaesthesia generates frontal alpha oscillations as early as 6 months of age, whereas strong delta oscillations are present at birth. In adults, delta oscillations and alpha oscillations are coupled: the phase of delta waves modulates the amplitude of alpha oscillations in a phenomenon known as phase-amplitude coupling. We hypothesise that delta-alpha phase-amplitude coupling exists in young children and is a feature of sevoflurane-based general anaesthesia distinct from emergence after anaesthesia...
March 13, 2023: British Journal of Anaesthesia
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