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British Journal of Anaesthesia

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https://read.qxmd.com/read/31101324/obstructive-sleep-apnoea-innocent-bystander-or-associate-in-crime
#1
LETTER
Ruggero M Corso, Stefano Maitan, Davide Cattano
No abstract text is available yet for this article.
May 14, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31101323/preoperative-chronic-beta-blocker-prescription-in-elderly-patients-as-a-risk-factor-for-postoperative-mortality-stratified-by-preoperative-blood-pressure-a-cohort-study
#2
Sudhir Venkatesan, Mads Emil Jørgensen, Helen J Manning, Charlotte Andersson, Abdul M Mozid, Mark Coburn, S Ramani Moonesinghe, Pierre Foex, Monty Mythen, Michael P W Grocott, Jonathan G Hardman, Puja R Myles, Robert D Sanders
BACKGROUND: Recent data suggest that beta blockers are associated with increased perioperative risk in hypertensive patients. We investigated whether beta blockers were associated with an increased risk in elderly patients with raised preoperative arterial blood pressure. METHODS: We conducted a propensity-score-matched cohort study of primary care data from the UK Clinical Practice Research Datalink (2004-13), including 84 633 patients aged 65 yr or over. Conditional logistic regression models, including factors that were significantly associated with the outcome, were constructed for 30-day mortality after elective noncardiac surgery...
May 14, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31097200/xenon-for-traumatic-brain-injury-a-noble-step-forward-and-a-wet-blanket
#3
EDITORIAL
Niccolò Terrando, David S Warner
No abstract text is available yet for this article.
May 13, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31084986/hyperglycaemia-augments-lipopolysaccharide-induced-reduction-in-rat-and-human-macrophage-phagocytosis-via-the-endoplasmic-stress-c-ebp-homologous-protein-pathway
#4
J Iida, S Ishii, Y Nakajima, D I Sessler, H Teramae, K Kageyama, S Maeda, N Anada, M Shibasaki, T Sawa, Y Nakayama
BACKGROUND: Macrophage phagocytosis constitutes an essential part of the host defence against microbes and the resolution of inflammation. Hyperglycaemia during sepsis is reported to reduce macrophage function, and thus, potentiate inflammatory deterioration. We investigated whether high-glucose concentrations augment lipopolysaccharide-induced reduction in macrophage phagocytosis via the endoplasmic stress-C/EBP homologous protein (CHOP) pathway using animal and laboratory investigations...
May 10, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31084985/remote-ischaemic-preconditioning-does-not-modulate-the-systemic-inflammatory-response-or-renal-tubular-stress-biomarkers-after-endotoxaemia-in-healthy-human-volunteers-a-single-centre-mechanistic-randomised-controlled-trial
#5
J Zwaag, R Beunders, M C Warlé, J A Kellum, N P Riksen, P Pickkers, M Kox
BACKGROUND: Remote ischaemic preconditioning (RIPC) consists of repeated cycles of limb ischaemia and reperfusion, which may reduce perioperative myocardial ischaemic damage and kidney injury. We hypothesised that RIPC may be beneficial by attenuating the systemic inflammatory response. We investigated whether RIPC affects the response in humans to bacterial endotoxin (lipopolysaccharide [LPS]) by measuring plasma cytokines and renal cell-cycle arrest mediators, which reflect renal tubular stress...
May 10, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31079836/chronic-pain-a-review-of-its-epidemiology-and-associated-factors-in-population-based-studies
#6
Sarah E E Mills, Karen P Nicolson, Blair H Smith
Chronic pain is a common, complex, and distressing problem that has a profound impact on individuals and society. It frequently presents as a result of a disease or an injury; however, it is not merely an accompanying symptom, but rather a separate condition in its own right, with its own medical definition and taxonomy. Studying the distribution and determinants of chronic pain allows us to understand and manage the problem at the individual and population levels. Targeted and appropriate prevention and management strategies need to take into account the biological, psychological, socio-demographic, and lifestyle determinants and outcomes of pain...
May 9, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31079835/electroencephalography-guided-anaesthetic-administration-does-not-impact-postoperative-delirium-among-older-adults-undergoing-major-surgery-an-independent-discussion-of-the-engages-trial
#7
EDITORIAL
https://read.qxmd.com/read/31076087/informing-future-intensive-care-trials-with-machine-learning
#8
EDITORIAL
Matthieu Komorowski, Malcolm Lemyze
No abstract text is available yet for this article.
May 7, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31060732/perioperative-diabetic-ketoacidosis-associated-with-sodium-glucose-co-transporter-2-inhibitors-a-systematic-review
#9
REVIEW
Venkatesan Thiruvenkatarajan, Emily Jane Meyer, Nagesh Nanjappa, Roelof M Van Wijk, David Jesudason
BACKGROUND: Perioperative diabetic ketoacidosis (DKA) with near-normal blood glucose concentrations, termed euglycaemic ketoacidosis (EDKA), is an adverse effect associated with sodium-glucose co-transporter-2 inhibitors (SGLT2i). Guidelines are still evolving concerning the perioperative management of patients on SGLT2i. We performed a systematic review of published reports of DKA from SGLT2i in the surgical setting to understand better the clinical presentation and characteristics of SGLT2i-associated DKA...
May 3, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31056241/complex-regional-pain-syndrome-a-narrative-review-for-the-practicing-clinician
#10
REVIEW
H Shim, J Rose, S Halle, P Shekane
Complex regional pain syndrome (CRPS) is a life-altering condition that usually affects the extremities after a trauma or nerve injury. The physiologic changes that occur as a result of the inciting injury are complex, as the name of the syndrome implies. The pain and disability associated with CRPS often lead to psychological co-morbidities that create a vicious cycle of pain, isolation, and depression. We review recent developemnts in the understanding of CRPS and advancements in management of this syndrome...
May 2, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31056240/frailty-assessment-from-clinical-to-radiological-tools
#11
REVIEW
Itay Bentov, Stephen J Kaplan, Tam N Pham, May J Reed
Frailty is a syndrome of cumulative decline across multiple physiological systems, which predisposes vulnerable adults to adverse events. Assessing vulnerable patients can potentially lead to interventions that improve surgical outcomes. Anaesthesiologists who care for older patients can identify frailty to improve preoperative risk stratification and subsequent perioperative planning. Numerous clinical tools to diagnose frailty exist, but none has emerged as the standard tool to be used in clinical practice...
May 2, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31056239/adductor-canal-versus-femoral-triangle-anatomical-locations-for-continuous-catheter-analgesia-after-total-knee-arthroplasty-a-multicentre-randomised-controlled-study
#12
A Chuan, A Lansdown, K L Brick, A J G Bourgeois, L B Pencheva, B Hue, S Goddard, M J Lennon, A Walters, D Auyong
BACKGROUND: Adductor canal (AC) catheters are being used to provide continuous postoperative analgesia after total knee arthroplasty (TKA) surgery. There are anatomical arguments that most AC catheters are being inserted into the femoral triangle (FT) compartment of the thigh rather than the AC compartment. The clinical relevance of this is unknown with respect to motor weakness, quality of analgesia, and opioid consumption. We hypothesised that AC catheters provide superior functional mobilisation on postoperative Day 1 after TKA as measured using the Timed Up and Go (TUG) test...
May 2, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31056238/role-of-specific-presynaptic-calcium-channel-subtypes-in-isoflurane-inhibition-of-synaptic-vesicle-exocytosis-in-rat-hippocampal-neurones
#13
Yuko Koyanagi, Christina L Torturo, Daniel C Cook, Zhenyu Zhou, Hugh C Hemmings
BACKGROUND: P/Q- and N-type voltage-gated calcium channels (VGCC) are the principal subtypes mediating synaptic vesicle (SV) exocytosis. Both the degree of isoflurane inhibition of SV exocytosis and VGCC subtype expression vary between brain regions and neurotransmitter phenotype. We hypothesised that differences in VGCC subtype expression contribute to synapse-selective presynaptic effects of isoflurane. METHODS: We used quantitative live-cell imaging to measure exocytosis in cultured rat hippocampal neurones after transfection of the fluorescent biosensor vGlut1-pHluorin...
May 2, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31054772/optimising-organ-perfusion-in-the-high-risk-surgical-patient-and-icu-patient-a-narrative-review
#14
REVIEW
Thomas Parker, David Brealey, Alex Dyson, Mervyn Singer
Maintenance or prompt restoration of an oxygen supply sufficient to facilitate adequate cellular metabolism is fundamental in maintaining organ function. This is particularly relevant when metabolic needs change markedly, for example in response to major surgery or critical illness. The consequences of inadequate tissue oxygenation include wound and anastomotic breakdown, organ dysfunction, and death. However, our ability to identify those at risk and to promptly recognise and correct tissue hypoperfusion is limited...
May 2, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31053233/special-issue-on-suspected-perioperative-allergic-reactions
#15
EDITORIAL
Lene H Garvey, Philip M Hopkins
No abstract text is available yet for this article.
April 30, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31053232/the-sensory-and-affective-components-of-pain-are-they-differentially-modifiable-dimensions-or-inseparable-aspects-of-a-unitary-experience-a-systematic-review
#16
REVIEW
K Talbot, V J Madden, S L Jones, G L Moseley
Pain is recognised to have both a sensory dimension (intensity) and an affective dimension (unpleasantness). Pain feels like a single unpleasant bodily experience, but investigations of human pain have long considered these two dimensions of pain to be separable and differentially modifiable. The evidence underpinning this separability and differential modifiability is seldom presented. We aimed to fill this gap by evaluating the current evidence base for whether or not the sensory and affective dimensions of pain can be selectively modulated using cognitive manipulations...
April 30, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31047645/objective-monitoring-of-nociception-a-review-of-current-commercial-solutions
#17
REVIEW
Thomas Ledowski
Nociception, in contrast to pain, is not a subjective feeling, but the physiological encoding and processing of nociceptive stimuli. However, monitoring nociception remains a challenge in attempts to lower the incidence of acute postoperative pain and the move towards a more automated approach to analgesia and anaesthesia. To date, several commercialised devices promise a more accurate reflection of nociception than the traditionally used vital signs, blood pressure and heart rate. This narrative review presents an overview of existing technologies and commercially available devices, and offers a perspective for future research...
April 30, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31047646/effectiveness-of-high-f-i-o-2-in-patients-undergoing-surgery-trial-sequential-analysis-comment-on-br-j-anaesth-2019-122-325
#18
LETTER
Hyun-Kyu Yoon, Yongsuk Kwon, Won Ho Kim
No abstract text is available yet for this article.
April 29, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31036258/parental-understanding-of-their-child-s-risk-of-anaesthesia
#19
LETTER
Craig Morrison, Rebecca Munk, Justine J S Lo, Tanya Przybylko, Ryan Hughes, Allan M Cyna
No abstract text is available yet for this article.
April 26, 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/31030988/neurosteroid-dehydroepiandrosterone-sulphate-enhances-pain-transmission-in-rat-spinal-dorsal-horn
#20
Goh Yamamoto, Yoshinori Kamiya, Mika Sasaki, Miho Ikoma, Hiroshi Baba, Tatsuro Kohno
BACKGROUND: The neurosteroid dehydroepiandrosterone sulphate (DHEAS) activates the sigma-1 receptor, inhibits gamma-aminobutyric acid A (GABAA ) and glycine receptors, and induces hyperalgesic effects. Although its effects have been studied in various tissues of the nervous system, its synaptic mechanisms in nociceptive pathways remain to be elucidated. METHODS: The threshold of mechanical hypersensitivity and spontaneous pain behaviour was assessed using the von Frey test in adult male Wistar rats after intrathecal administration of DHEAS...
April 25, 2019: British Journal of Anaesthesia
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