Viola Neudecker, Jose F Perez-Zoghbi, Oscar Miranda-Domínguez, Katie J Schenning, Julian Sb Ramirez, A J Mitchell, Anders Perrone, Eric Earl, Sam Carpenter, Lauren D Martin, Kristine Coleman, Martha Neuringer, Christopher D Kroenke, Gregory A Dissen, Damien A Fair, Ansgar M Brambrink
BACKGROUND: Clinical studies suggest that anaesthesia exposure early in life affects neurobehavioural development. We designed a non-human primate (NHP) study to evaluate cognitive, behavioural, and brain functional and structural alterations after isoflurane exposure during infancy. These NHPs displayed decreased close social behaviour and increased astrogliosis in specific brain regions, most notably in the amygdala. Here we hypothesise that resting-state functional connectivity MRI can detect alterations in connectivity of brain areas that relate to these social behaviours and astrogliosis...
September 13, 2023: British Journal of Anaesthesia