Fengping Zhang, Taotao Shi, Xiaoran Feng, Yunying Shi, Guilin Zhang, Yu Liu, Ping Fu
BACKGROUND: The prognosis of diabetic peritoneal dialysis patients is poor. HbA1c serves as a crucial indicator for monitoring blood glucose control in patients with diabetes. Nevertheless, the relationship between visit-to-visit HbA1c variability and prognosis in peritoneal dialysis with diabetes remains unclear. METHODS: All participants were categorized into 3 groups based on the HbA1c variability score (HVS), which is the frequency of 0.5% (5.5 mmol/mol) alter in visit-to-visit HbA1c values...
September 29, 2023: BMC Nephrology
Mengjun Liang, Shiyan Zhu, Shaoqin Liu, Jianquan Chen, Danni Li, Chengzhi Luo, Xiaowen Wang, Zongpei Jiang
BACKGROUND: Gaucher disease (GD) is a rare autosomal recessive inherited, lysosomal storage disoder that involves liver, spleen, lung, bone, bone marrow even central nervous. However, GD associated membranoproliferative glomerulonephritis (MPGN) is seldom reported. CASE PRESENTATION: Here we described a case of 35-year-old man suffering from GD with hepatosplenomegaly, ascites, bone destruction, myelofibrosis and MPGN. Renal biopsy revealed MPGN and Gaucher cells presented in the glomeruli capillaries...
September 29, 2023: BMC Nephrology
Yuki Shimamoto, Hirohito Sasaki, Kenji Kasuno, Yuki Watanabe, Sayumi Sakashita, Sho Nishikawa, Kazuhisa Nishimori, Sayu Morita, Yudai Nishikawa, Mamiko Kobayashi, Sachiko Fukushima, Soichi Enomoto, Naoki Takahashi, Tadanori Hamano, Ippei Sakamaki, Hiromichi Iwasaki, Masayuki Iwano
BACKGROUND: Endothelial dysfunction is common in patients undergoing chronic haemodialysis, and is a major cause of posterior reversible encephalopathy syndrome (PRES). Recently, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to cause endothelial dysfunction by infecting vascular endothelial cells. Several cases of neurological complications in patients without kidney dysfunction, and only a few cases in patients with chronic kidney disease, have been reported in the literature...
September 29, 2023: BMC Nephrology
Andrêza Soares Dos Santos, Sara Teles de Menezes, Isabella Ribeiro Silva, William Neves Oliveira, Mariana Linhares Pereira, José Geraldo Mill, Sandhi Maria Barreto, Roberta Carvalho Figueiredo
OBJECTIVE: Investigate the longitudinal association of use and time of use of proton pump inhibitors (PPI) with incidence of chronic kidney disease (CKD) and kidney function change. METHODS: Prospective study with 13,909 participants from baseline (2008-2010) and second wave (2012-2014) of the ELSA-Brasil (mean interval between visits = 3.9 years (1.7-6.0)). Participants answered about use and time use of the PPI in the two weeks prior the interview...
September 28, 2023: BMC Nephrology
Masoumeh Hosseinpour, Aiyoub Pezeshgi, Morteza Zaboli Mahdiabadi, Foroogh Sabzghabaei, Hamed Hajishah, Soheila Mahdavynia
BACKGROUND: A kidney recipient's urinary tract infection (UTI) can result in infectious problems and be a risk factor for less successful transplant outcomes. UTI risk factors are still controversial. The present study aimed to investigate the prevalence of UTI and its association with risk factors in kidney recipients. METHOD: Twenty-six papers published between 2005 and 2022 were retrieved using keywords and searching Medlib, ScienceDirect, PubMed, and other databases...
September 27, 2023: BMC Nephrology
Jing Xu, Xinlu Wang, Qinjie Weng, Xiaobei Feng, Xiaoxia Pan
BACKGROUND: Membranous nephropathy (MN) is a major pattern of nephrotic syndrome (NS) in adults. Some MN have secondary causes and some may be accompanied with other glomerular diseases. MN patients coexisting with amyloidosis are very rare, and mostly was polytypic MN. Herein, we describe the first report which identifying monotype PLA2R-MN (κ light chain) concurrent with leukocyte chemotactic factor 2 amyloidosis (ALECT2). This rare case highlights the importance of renal pathology for diagnosis...
September 26, 2023: BMC Nephrology
Masoume Rambod, Nilofar Pasyar, Ali Mohammad Parviniannasab
BACKGROUND: End Stage Renal Disease (ESRD) patients undergoing hemodialysis are faced with serious problems in their lives. Hope, as a multifaceted factor, plays a critical role in these patients' lives. Given the multifaceted process of hope, this study aimed to describe hope and identify the challenges, strategies, and outcomes of hope in Iranian ESRD patients undergoing hemodialysis. METHODS: This is a qualitative study using content analysis. The participants were selected using purposive sampling...
September 22, 2023: BMC Nephrology
Cheng Xue, Jian Wang, Jinyan Pan, Congdie Liang, Chenchen Zhou, Jun Wu, Shuwei Song, Linlin Cui, Liming Zhang, Yawei Liu, Bing Dai
Rituximab (RTX) and cyclophosphamide (CYC) based treatments are both recommended as first-line therapies in idiopathic membranous nephropathy (IMN) by KDIGO 2021 guideline. However, the efficacy of RTX vs. CYC-based treatments in IMN is still controversial. We performed this systemic review and meta-analysis registered in PROSPERO (CRD 42,022,355,717) by pooling data from randomized controlled trials or cohort studies in IMN patients using the EMBASE, PubMed, and Cochrane libraries (till Orc 1, 2022). The primary outcomes were the complete remission (CR) rate + partial remission (PR) rate...
September 22, 2023: BMC Nephrology
Chance S Dumaine, Danielle E Fox, Pietro Ravani, Maria J Santana, Jennifer M MacRae
BACKGROUND: Modality transitions represent a period of significant change that can impact health related quality of life (HRQoL). We explored the HRQoL of adults transitioning to new or different dialysis modalities. METHODS: We recruited eligible adults (≥ 18) transitioning to dialysis from pre-dialysis or undertaking a dialysis modality change between July and September 2017. Nineteen participants (9 incident and 10 prevalent dialysis patients) completed the KDQOL-36 survey at time of transition and three months later...
September 22, 2023: BMC Nephrology
Mulualem Keneni, Rajalakshmi Murugan, Ketema Bizuwork, Tesfaye Asfaw, Sosina Tekle, Gadissa Tolosa, Assefa Desalew
BACKGROUND: Acute kidney injury (AKI) is a serious health problem in critically ill children. It is associated with poor treatment outcomes and high morbidity and mortality rates. Globally, one in three critically ill children suffers from acute kidney injury. However, limited data are available in Africa, particularly Ethiopia, which highlighting the risk factors related to acute kidney injury. Therefore, this study aimed to identify the risk factors associated with acute kidney injury among critically ill children admitted to the pediatric intensive care unit (PICU) at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia...
September 21, 2023: BMC Nephrology
Yasmine Salah Naga, Noha Alaa Hamdy, Amany El Bassiouny, Mohamed Selim, Samar Samy Abd ElHafeez
BACKGROUND: Hemodialysis (HD) patients commonly receive polypharmacy leading to increased likelihood of drug related problems (DRPs) and poor quality of life. Medication Therapy Management (MTM) services discover and resolve DRPs and may specifically improve Medication-burden Quality of life (MBQoL) in HD patients. We aimed to assess the effect of MTM services on DRPs and MBQoL among HD patients. METHODS: A prospective pre-post study was conducted on 104 patients in an HD unit in Alexandria, Egypt...
September 20, 2023: BMC Nephrology
Florent Von Tokarski, Alexandre Fillon, Valentin Maisons, Benjamin Thoreau, Guillaume Bayer, Philippe Gatault, Hélène Longuet, Bénédicte Sautenet, Matthias Buchler, Cécile Vigneau, Fadi Fakhouri, Jean-Michel Halimi
BACKGROUND: Thrombotic microangiopathies (TMAs) are rare but can be severe in kidney transplant. recipients (KTR). METHODS: We analysed the epidemiology of adjudicated TMA in consecutive KTR during the. 2009-2021 period. RESULTS: TMA was found in 77/1644 (4.7%) KTR. Early TMA (n = 24/77 (31.2%); 1.5% of all KTR) occurred during the first two weeks ((median, IQR) 3 [1-8] days). Triggers included acute antibody-mediated rejection (ABMR, n = 4) and bacterial infections (n = 6)...
September 20, 2023: BMC Nephrology
Fangfang Xu, Bing Zhuang, Zhongxia Wang, Hao Wu, Xin Hui, Hongyan Peng, Xueqin Bian, Hong Ye
BACKGROUND: Good knowledge of and attitudes toward hemodialysis and its complications might be expected to promote good practices and improve adherence. This study investigated, the knowledge, attitude, and practice of patients receiving hemodialysis regarding hemodialysis and its complications. METHODS: This cross-sectional study enrolled patients with uremia who were receiving hemodialysis at the Second Affiliated Hospital of Nanjing Medical University (China) between January 9, 2023, and January 16, 2023...
September 20, 2023: BMC Nephrology
Mohammad Ali Tabibi, Kenneth R Wilund, Nasrin Salimian, Saghar Nikbakht, Mahsa Soleymany, Zahra Roshanaeian, Farzad Nazemi, Saghar Ahmadi
BACKGROUND: Patients with kidney failure experience derangements of circulating markers of mineral metabolism and dysregulation of skeletal and cardiovascular physiology which results in high mortality rate in these patients. This study aimed to evaluate the effect of intradialytic exercise on regulation of these abnormalities in patients receiving chronic hemodialysis (HD). METHODS: In this randomized controlled trial conducted in an HD center in Iran, adult patients receiving chronic HD were randomized to intradialytic exercise (60 min) in the second hour of thrice weekly dialysis for 6 months (intervention) or no intradialytic exercise (control)...
September 20, 2023: BMC Nephrology
Bodil G Hornstrup, Nikolai Hoffmann-Petersen, Thomas Guldager Lauridsen, Jesper N Bech
PURPOSE: Patients with treatment resistant hypertension (TRH) are at particular risk of cardiovascular disease. Life style modification, including sodium restriction, is an important part of the treatment of these patients. We aimed to analyse if self-performed dietary sodium restriction could be implemented in patients with TRH and to evaluate the effect of this intervention on blood pressure (BP). Moreover, we aimed to examine if mechanisms involving nitric oxide, body water content and BNP, renal function and handling of sodium were involved in the effect on nocturnal and 24-h BP...
September 19, 2023: BMC Nephrology
Kristina Boss, Margret Paar, Katja Waterstradt, Kerstin Schnurr, Philipp Ickerott, Ulrike Wieneke, Ralf Spitthöver, Karl Oettl, Andreas Kribben
BACKGROUND AND AIM: Maintenance haemodialysis patients have increased morbidity and mortality which is mainly driven by an elevated inflammation level due to the uraemic milieu. A major part of this increased inflammation level is the degree of oxidative stress which can be assessed by albumin redox state (ARS). Aim of this study was to evaluate how the ARS is affected by a haemodialysis treatment and different dialyzer properties. METHODS: ARS was determined before and after haemodialysis treatment by fractionating it into reduced human mercaptalbumin (HMA), reversibly oxidized human non-mercaptalbumin 1 (HNA-1), and irreversibly oxidized human non-mercaptalbumin 2 (HNA-2) by high-performance liquid chromatography...
September 18, 2023: BMC Nephrology
Susan J Lewis, Soo Min Jang, Bruce A Mueller
BACKGROUND: Few drug dosing recommendations for patients receiving home hemodialysis (HHD) have been published which has hindered the adoption of HHD. HHD regimens vary widely and differ considerably from conventional, thrice weekly, in-center hemodialysis in terms of treatment frequency, duration and blood and dialysate flow rates. Consequently, vancomycin and daptomycin clearances in HHD are also likely to be different, consequently HHD dosing regimens must be developed to ensure efficacy and minimize toxicity when these antibiotics are used...
September 14, 2023: BMC Nephrology
Yasmine Salah Naga, Ola Atef Sharaki, Eman Zaki Azzam, Eman Mohamed Mostafa Farag, Montasser Mohamed Hussein Zeid
BACKGROUND: Although testosterone has a pivotal role in bone health, its correlation with bone mineral density (BMD) is understudied in kidney transplant recipients who are at high risk of osteoporosis. This study aimed to elucidate if there is any correlation between serum free testosterone and BMD in this population. PATIENTS AND METHODS: Sixty male kidney transplant recipients were enrolled in this cross-sectional study, and they were subjected to history taking, clinical examination, and laboratory investigations (including total and free testosterone)...
September 14, 2023: BMC Nephrology
Azumi Hotta, Hirotsugu Iwatani
BACKGROUND: Patient education for the management of chronic kidney disease (CKD) is attracting attention. Therefore, this study aimed to analyze changes in body weight, uric acid, and estimated-glomerular filtration rate (eGFR) in patients with CKD after a group-based education during admission. METHODS: Overall, 157 patients with CKD, who were discharged from the nephrology department of our hospital between January 2015 and October 2019, received group-based education or individual-based education by nurses at admission...
September 14, 2023: BMC Nephrology
Dana Forcey, Dan Tran, Jenny Connor, Piriya Kusuma Na Ayudhya, Christian Ocampo, Craig Nelson, Sandra Crikis
BACKGROUND: Optimal vascular access is critical to successful haemodialysis. Acute thrombosis of haemodialysis access often leads to unplanned hospital admissions and interventions to restore patency. Western Health is a large health service in Victoria, Australia. During the period February 2019 to January 2020, the rate of arteriovenous fistula (AVF) and arteriovenous graft (AVG) at Western Health satellite dialysis units was 0.33 episodes per 1000 patient-days, higher than the reported rate in the literature of 0...
September 13, 2023: BMC Nephrology
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