We have located links that may give you full text access.
Association of deficits in short-term learning and Aβ and hippoampal volume in cognitively normal adults.
Neurology 2020 September 5
OBJECTIVE: To determine the extent to which deficits in learning over 6 days are associated with Aβ+ and hippocampal volume in CN adults.
METHODS: Eighty CN older adults who had undergone positron emission tomography (PET) neuroimaging to determine Aβ status (n=42 Aβ- and 38 Aβ+), magnetic resonance imaging (MRI) to determine hippocampal and ventricular volume and repeated assessment of memory were recruited from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Participants completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT), which required they learn associations between 50 Chinese characters and their English language equivalents over 6 days. ORCA-LLT assessments were supervised on the first day, and were completed remotely online for all remaining days.
RESULTS: Learning curves in the Aβ+ CNs were significantly worse than those in matched Aβ- CNs, with the magnitude of this difference very large (d(95%CI)=2.22(1,64,2.75), p <.001), and greater than differences between these groups for memory decline since their enrolment in AIBL (d(95%CI)=0.52(0.07,0.96), p =.021), or memory impairment at their most recent visit. In Aβ+ CN adults, slower rates of learning were associated with smaller hippocampal, and larger ventricular volumes.
CONCLUSIONS: These results suggest that in CNs, Aβ+ is associated more strongly with a deficit in learning than any aspect of memory dysfunction. Slower rates of learning in Aβ+ CNs were associated with hippocampal volume loss. Considered together, these data suggest that the primary cognitive consequence of Aβ+ is a failure to benefit from experience when exposed to novel stimuli, even over very short periods.
METHODS: Eighty CN older adults who had undergone positron emission tomography (PET) neuroimaging to determine Aβ status (n=42 Aβ- and 38 Aβ+), magnetic resonance imaging (MRI) to determine hippocampal and ventricular volume and repeated assessment of memory were recruited from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Participants completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT), which required they learn associations between 50 Chinese characters and their English language equivalents over 6 days. ORCA-LLT assessments were supervised on the first day, and were completed remotely online for all remaining days.
RESULTS: Learning curves in the Aβ+ CNs were significantly worse than those in matched Aβ- CNs, with the magnitude of this difference very large (d(95%CI)=2.22(1,64,2.75), p <.001), and greater than differences between these groups for memory decline since their enrolment in AIBL (d(95%CI)=0.52(0.07,0.96), p =.021), or memory impairment at their most recent visit. In Aβ+ CN adults, slower rates of learning were associated with smaller hippocampal, and larger ventricular volumes.
CONCLUSIONS: These results suggest that in CNs, Aβ+ is associated more strongly with a deficit in learning than any aspect of memory dysfunction. Slower rates of learning in Aβ+ CNs were associated with hippocampal volume loss. Considered together, these data suggest that the primary cognitive consequence of Aβ+ is a failure to benefit from experience when exposed to novel stimuli, even over very short periods.
Full text links
Related Resources
Trending Papers
Obesity pharmacotherapy in older adults: a narrative review of evidence.International Journal of Obesity 2024 May 7
SGLT2 Inhibitors in Kidney Diseases-A Narrative Review.International Journal of Molecular Sciences 2024 May 2
Use of Intravenous Albumin: A Guideline from the International Collaboration for Transfusion Medicine Guidelines.Chest 2024 March 5
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app