Sofiya Gancheva, Sabine Kahl, Christian Herder, Klaus Strassburger, Theresia Sarabhai, Kalliopi Pafili, Julia Szendroedi, Matthias Schlensak, Michael Roden
AIMS: Body weight loss improves insulin resistance and growth hormone secretion in obesity, which may be regulated by leptin according to preclinical studies. How changes in leptin, lipids and insulin sensitivity after bariatric (metabolic) surgery affect the human growth hormone system is yet unclear. PARTICIPANTS AND METHODS: People with obesity (OBE, n = 79, BMI 50.8 ± 6.3 kg/m2 ) were studied before, 2, 12, 24 and 52 weeks after metabolic surgery and compared to lean healthy humans (control; CON, n = 24, BMI 24...
March 23, 2023: International Journal of Obesity