Yueze Yang, Huan Liu, Dexi Liu
BACKGROUND AND OBJECTIVES: Interleukin-27 (IL-27) is a multifaceted heterodimer cytokine that exerts both pro-inflammatory and anti-inflammatory effects under different physiological conditions. IL-27 signaling plays a role in promoting energy expenditure through enhanced thermogenesis. The objective of the study is to determine the functional role of IL-27 in regulating weight gain, and glucose and lipid homeostasis in mice fed a high-fat diet (HFD). METHODS: C57BL/6 mice were hydrodynamically transferred with pLIVE-IL-27 plasmids to achieve elevated level of IL-27 in blood and then kept on a HFD for 8 weeks...
March 23, 2023: International Journal of Obesity
Sofiya Gancheva, Sabine Kahl, Christian Herder, Klaus Strassburger, Theresia Sarabhai, Kalliopi Pafili, Julia Szendroedi, Matthias Schlensak, Michael Roden
AIMS: Body weight loss improves insulin resistance and growth hormone secretion in obesity, which may be regulated by leptin according to preclinical studies. How changes in leptin, lipids and insulin sensitivity after bariatric (metabolic) surgery affect the human growth hormone system is yet unclear. PARTICIPANTS AND METHODS: People with obesity (OBE, n = 79, BMI 50.8 ± 6.3 kg/m2 ) were studied before, 2, 12, 24 and 52 weeks after metabolic surgery and compared to lean healthy humans (control; CON, n = 24, BMI 24...
March 23, 2023: International Journal of Obesity
Wujie Ye, Jingyu Xing, Zekai Yu, Xingang Hu, Yan Zhao
The long-term use of antipsychotics (APs) may cause a variety of diseases, such as metabolic syndrome, antipsychotic-induced weight gain (AIWG), and even obesity. This paper reviews the various mechanisms of AIWG and obesity in detail, involving genetics, the central nervous system, the neuroendocrine system, and the gut microbiome. The common drug and non-drug therapies used in clinical practice are also introduced, providing the basis for research on the molecular mechanisms and the future selection of treatments...
March 23, 2023: International Journal of Obesity
Xingang Sun, Yifan Yuan, Lu Chen, Mei Ye, Liangrong Zheng
BACKGROUND: Numerous studies have linked visceral adipose tissue (VAT) to gastrointestinal diseases. However, it remains unclear whether these associations reflect causal relationships. METHODS: We used a two-sample Mendelian randomization (MR) approach to elucidate the causal effect of VAT on nine non-tumour gastrointestinal diseases. The inverse-variance weighted method was used to perform the MR analyses. Complementary and multivariable MR analyses were performed to confirm the results...
March 18, 2023: International Journal of Obesity
Stephen Apfelroth
No abstract text is available yet for this article.
March 14, 2023: International Journal of Obesity
Jody C Hoenink, Thomas Burgoine, Soren Brage, Nita Forouhi, Simon J Griffin, Pablo Monsivais, Nicholas J Wareham, Amy Ahern, Jean Adams
BACKGROUND: Previous studies demonstrated a relation between takeaway outlet exposure and health outcomes. Individual characteristics, such as eating behaviour traits, could make some people more susceptible to the influence of the food environment. Few studies have investigated this topic. We aimed to investigate the moderating role of eating behaviour traits (cognitive restraint, uncontrolled eating and emotional eating) in the association between neighbourhood exposure to hot food takeaway outlets (hereafter referred to as takeaway outlets), and takeaway food consumption and adiposity...
March 14, 2023: International Journal of Obesity
Peng Wang, Menghui Liu, Xiaodong Zhuang, Yue Guo, Zhenyu Xiong, Lixiang He, Xiaojie Cai, Zhuohui Chen, Longyun Peng, Xinxue Liao
BACKGROUND: Obesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac structure and function. METHODS: A total of 3066 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study were included, who completed echocardiography in young adulthood and middle age...
March 10, 2023: International Journal of Obesity
Takako Miki, Akiko Nanri, Tetsuya Mizoue, Atsushi Goto, Mitsuhiko Noda, Norie Sawada, Shoichiro Tsugane
BACKGROUND: Accumulating evidence suggests that pneumonia mortality is lower for individuals with high body mass index (BMI) compared to normal BMI, but it remains unclear whether weight change during adulthood influences subsequent mortality due to pneumonia in Asian populations, who have a relatively lean body mass. This study aimed to examine the association of BMI and weight change over 5 years with the subsequent risk of pneumonia mortality in a Japanese population. METHODS: The present analysis included 79,564 Japan Public Health Center (JPHC)-based Prospective Study participants who completed a questionnaire between 1995 and 1998 were followed for death through 2016...
March 3, 2023: International Journal of Obesity
Andreea I Heriseanu, Eyal Karin, Jennie Walker, Amelia J Scott, Madelyne A Bisby, Milena Gandy, Joanne Dudeney, Alana Fisher, Nickolai Titov, Blake F Dear
BACKGROUND: There is growing evidence that internet-delivered cognitive behavioural therapy (iCBT) can improve functioning and reduce psychological distress in people with chronic health conditions. Obesity frequently co-occurs with chronic health conditions, yet its impact on response to psychological interventions in this population is not known. The current study examined associations between BMI and clinical outcomes (depression, anxiety, disability, and satisfaction with life) following a transdiagnostic iCBT program targeting adjustment to chronic illness...
March 3, 2023: International Journal of Obesity
David Primo, Olatz Izaola, Daniel de Luis
BACKGROUND: The resistin/uric index has been considered a prognostic factor for identifying young people with obesity. Obesity and Metabolic Syndrome (MS) are an important health problem in females. AIMS: The objective of this work was to evaluate the relationship of resistin/acid uric index with Metabolic Syndrome on Caucasian females with obesity. METHODS: We conducted a cross sectional study in 571 females with obesity. Measurements of anthropometric parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C reactive protein, uric acid, resistin and prevalence of Metabolic Syndrome were determined...
March 2, 2023: International Journal of Obesity
Blandine Laferrère
No abstract text is available yet for this article.
February 27, 2023: International Journal of Obesity
Kinsey Pebley, Zoran Bursac, Robert C Klesges, Jon O Ebbert, Catherine R Womack, Julia Graber, Melissa A Little, Karen J Derefinko, Rebecca A Krukowski
BACKGROUND/OBJECTIVES: Weight gain is a barrier to smoking cessation. Previous interventions targeting weight gain while quitting smoking have largely been unsuccessful. The current study aimed to assess the efficacy of weight stability and weight loss interventions compared to a low-intensity, self-guided bibliotherapy weight management group. SUBJECTS/METHODS: A randomized controlled trial with 12-month follow-up from 2018 to 2022 was conducted with participants (N = 305) who reported smoking at least five cigarettes per day for the last year and interest in quitting initially recruited from the Memphis, TN, USA area...
February 25, 2023: International Journal of Obesity
Candida J Rebello, Dachuan Zhang, John P Kirwan, Adam C Lowe, Carlante J Emerson, Chelsea L Kracht, Lori C Steib, Frank L Greenway, William D Johnson, Justin C Brown
BACKGROUND AND OBJECTIVE: The effect of exercise training on whole-body insulin sensitivity has not been systematically summarized. We aimed to summarize the data from randomized controlled trials evaluating the effect of exercise training on insulin action, in adults. SUBJECTS: MEDLINE, EMBASE, and CENTRAL databases were searched until January 2021. Randomized controlled trials lasting ≥4 weeks, including adults, and evaluating the effect of exercise on insulin-stimulated glucose disposal measured using the hyperinsulinemic euglycemic clamp, were included...
February 24, 2023: International Journal of Obesity
C Sundgot-Borgen, D S Bond, F F Sniehotta, I L Kvalem, B H Hansen, I Bergh, Ø Rø, T Mala
BACKGROUND: Increasing physical activity and limiting sedentary time may minimize weight recurrence after bariatric surgery. However, few studies have evaluated potential associations of objectively-measured physical activity and sedentary time with post-surgical weight recurrence over time. AIMS: To evaluate associations of change in physical activity and sedentary time with weight recurrence after bariatric surgery. METHODS: Participants from the Oslo Bariatric Surgery Study, a prospective cohort study, wore an ActiGraph monitor for seven days at 1- and 5 years after surgery to assess daily physical activity and sedentary time...
February 24, 2023: International Journal of Obesity
Ville-Petteri Mäkinen, Johannes Kettunen, Terho Lehtimäki, Mika Kähönen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Järvelin, Olli T Raitakari, Mika Ala-Korpela
BACKGROUND/OBJECTIVE: This observational study dissects the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR) and circulating metabolomics using a combination of longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. SUBJECTS/METHODS: Firstly, a data-driven subgrouping algorithm was employed to simplify high-dimensional metabolic profiling data into a single categorical variable: a self-organizing map (SOM) was created from 174 metabolic measures from cross-sectional surveys (FINRISK, n = 9708, ages 25-74) and a birth cohort (NFBC1966, n = 3117, age 31 at baseline, age 46 at follow-up) and an expert committee defined four subgroups of individuals based on visual inspection of the SOM...
February 23, 2023: International Journal of Obesity
Shanat Baig, Subadra Wanninayake, Lukas Foggensteiner, Yasir S Elhassan, Konstantinos Manolopoulos, Sadaf Ali, Pierre Bel Lassen, Karine Clément, Richard P Steeds, Jeremy W Tomlinson, Tarekegn Geberhiwot
BACKGROUND: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive syndromic obesity of childhood onset among many other features. To date, the excess risk of metabolic complications of severe early-onset obesity in BBS remains controversial. In-depth investigation of adipose tissue structure and function with detailed metabolic phenotype has not been investigated yet. OBJECTIVE: To investigate adipose tissue function in BBS. DESIGN: A prospective cross-sectional study...
February 20, 2023: International Journal of Obesity
Bernd Schultes, Barbara Ernst, Katharina Timper, Jardena Puder, Gottfried Rudofsky
No abstract text is available yet for this article.
February 18, 2023: International Journal of Obesity
Piniel Alphayo Kambey, Lalit Dzifa Kodzo, Fattimah Serojane, Bolorunduro Janet Oluwasola
BACKGROUND: The globally high prevalence of both obesity and bipolar disorder makes the bidirectional relationship between the two disorders a pivotal phenomenon; hence, a meta-analysis to synopsize their co-occurrence is indispensable. Psychotropic-induced obesity has been reported to be an important factor linking bipolar disorder and obesity. Nonetheless, the molecular signature of this connection is perplexing. METHODS: Here, we leverage both meta-analysis and bioinformatics analysis to provide a conspectus and deduce the molecular signature of obesity in bipolar disease patients following psychotropic treatment...
February 18, 2023: International Journal of Obesity
Khushdeep Bandesh, Michael Traurig, Peng Chen, Wen-Chi Hsueh, Robert L Hanson, Paolo Piaggi, Leslie J Baier
BACKGROUND: Genome-wide association studies have shown that body mass index (BMI), an estimate of obesity, is highly polygenic. Individual variants typically have small effect sizes, making it challenging to identify unique loci in under-represented ethnic groups which lack statistical power due to their small sample size. Yet obesity is a major health disparity and is particularly prevalent in southwestern American Indians. Here, we identify and characterize a new locus for BMI that was detected by analyzing moderate associations with BMI obtained in a population-based sample of southwestern American Indians together with the well-powered GIANT dataset...
February 17, 2023: International Journal of Obesity
Keita Kinoshita, Naoki Ozato, Tohru Yamaguchi, Hiroto Bushita, Motoki Sudo, Yukari Yamashiro, Kenta Mori, Yoshihisa Katsuragi, Hiroyuki Sasai, Koichi Murashita, Yoshiko Takahashi, Kazushige Ihara
BACKGROUND: Several studies have reported that the coronavirus disease (COVID-19) pandemic has increased sedentary behaviour and obesity; however, these analyses used self-reported data, and the association between sedentary behaviour and visceral fat and adipocytokines during the COVID-19 pandemic remains unclear. We aimed to investigate the association of the COVID-19 pandemic with objectively measured sedentary behaviour and these obesity-related factors. METHODS: Longitudinal analysis was conducted on 257 Japanese participants who underwent health check-ups in 2018 before and in 2020 during the COVID-19 pandemic...
February 16, 2023: International Journal of Obesity
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