Yasuharu Tabara, Aya Shoji-Asahina, Aya Ogawa, Yoko Sato
BACKGROUND: Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy obesity by comparing clinical profile-matched metabolically healthy obesity and non-obesity groups. METHODS: We analyzed a health insurance dataset with annual health checkup data from Japan. The analyzed data included 168,699 individuals aged <65 years...
May 18, 2024: International Journal of Obesity
Georgia Argyrakopoulou, Evdoxia Gitsi, Sofia K Konstantinidou, Alexander Kokkinos
Obesity pharmacotherapy represents a promising approach to treating obesity and may provide benefits beyond weight loss alone. Maintaining or even increasing muscle mass during weight loss is important to overall health, metabolic function and weight loss maintenance. Drugs such as liraglutide, semaglutide, tirzepatide, and naltrexone/bupropion have shown significant weight loss effects, and emerging evidence suggests they may also have effects on body composition, particularly a positive influence on muscle mass...
May 14, 2024: International Journal of Obesity
Mary A Gerend, Lucille J Wilkinson, Angelina R Sutin, Javier I Rosado, Katherine B Ehrlich, David W Smith, Jon K Maner
BACKGROUND: Perceived weight discrimination is associated with increased risk for chronic diseases and reduced life expectancy. Nevertheless, little is known about perceived weight discrimination in racial, ethnic, and sexual minority groups or in individuals at the intersections of those groups. The goal of this study was to identify sociodemographic predictors of perceived weight discrimination. SUBJECTS/METHODS: A diverse sample of adults (37% Black/African American, 36% Latino, 29% sexual minority) with a body mass index (BMI) ≥ 18...
May 13, 2024: International Journal of Obesity
Gitte Hedermann, Paula L Hedley, Kasper Gadsbøll, Ida N Thagaard, Lone Krebs, Christian M Hagen, Thorkild I A Sørensen, Michael Christiansen, Charlotte K Ekelund
OBJECTIVE: To evaluate the association between maternal BMI and congenital heart defects (CHDs) in the offspring when including live births, stillbirths, aborted and terminated pregnancies and to investigate if maternal interpregnancy weight changes between the first and second pregnancy influences the risk of foetal CHDs. METHODS: A nationwide cohort study of all singleton pregnancies in Denmark from 2008 to 2018. Data were retrieved from the Danish Foetal Medicine Database, which included both pre- and postnatal diagnoses of CHDs...
May 11, 2024: International Journal of Obesity
James Naude, Ali Zentner, Priya Suresh, Jesse Bittman, Nadia A Khan
OBJECTIVE: Little is known about the effect of a multi-drug weight loss strategy in obesity treatment, particularly combining bupropion/naltrexone and glucagon-like peptide 1 (GLP-1) analogue. The purpose of this study was to evaluate if there are any additive effects of prescribing bupropion/naltrexone on top of GLP-1 analogue as weight loss therapy. METHODS: This was a retrospective cohort study of adult patients with a body mass index (BMI) ≥ 30 kg/m2 prescribed GLP-1 analogue therapy at an obesity specialist clinic in Vancouver, Canada...
May 9, 2024: International Journal of Obesity
Tugba Barlas, Alev Eroglu Altinova, Mujde Akturk, Fusun Balos Toruner
No abstract text is available yet for this article.
May 7, 2024: International Journal of Obesity
Chengu Niu, Jing Zhang, Hina Ukrani, Yujing Han, Dilendra Weerasinghe, Mallory Balmer-Swain, Nagesh Jadhav, Patrick I Okolo
BACKGROUND: The global surge in obesity presents a significant health challenge, leading to increased adoption of bariatric surgery as an intervention. However, the correlation between bariatric surgery and cardiovascular outcomes during subsequent pregnancies remains unclear. The aim of our study was to determine the prevalence of cardiovascular complications during delivery hospitalizations in patients with bariatric procedure. METHODS: We performed a retrospective analysis utilizing the National Inpatient Sample database to examine data from delivery admissions of pregnant women with obesity and a history of bariatric surgery...
May 7, 2024: International Journal of Obesity
George A Bray
This review has examined the scientific basis for our current understanding of obesity that has developed over the past 100 plus years. Obesity was defined as an excess of body fat. Methods of establishing population and individual changes in levels of excess fat are discussed. Fat cells are important storage site for excess nutrients and their size and number affect the response to insulin and other hormones. Obesity as a reflection of a positive fat balance is influenced by a number of genetic and environmental factors and phenotypes of obesity can be developed from several perspectives, some of which have been elaborated here...
May 7, 2024: International Journal of Obesity
Alex E Henney, John P H Wilding, Uazman Alam, Daniel J Cuthbertson
The prevalence of obesity in older adults (people aged >60 years) is increasing in line with the demographic shift in global populations. Despite knowledge of obesity-related complications in younger adults (increased risk of type 2 diabetes, liver and cardiovascular disease and malignancy), these considerations may be outweighed, in older adults, by concerns regarding weight-loss induced reduction in skeletal muscle and bone mass, and the awareness of the 'obesity paradox'. Obesity in the elderly contributes to various obesity-related complications from cardiometabolic disease and cancer, to functional decline, worsening cognition, and quality of life, that will have already suffered an age-related decline...
May 6, 2024: International Journal of Obesity
H C Craig, D Alsaeed, H Heneghan, W Al-Najim, E Al Ozairi, C W le Roux
OBJECTIVE: Obesity-related problems can now be managed with effective nutritional therapy, pharmacotherapy, and surgeries that achieve >10% weight loss. Assessing patient preferences, treatment choices, and factors affecting patients can improve treatment compliance and efficacy. Our aim was to identify factors affecting patient preference and subsequent choice of pharmacotherapy among those seeking treatment for obesity-related disorders. METHODS: A participatory action study using purposeful sampling recruited 33 patients with obesity complications...
May 1, 2024: International Journal of Obesity
Gaurav Kudchadkar, Oluwatosin Akinsiku, Marleigh Hefner, Princess Uchechi Ozioma, Holli Booe, Nikhil V Dhurandhar
No abstract text is available yet for this article.
May 1, 2024: International Journal of Obesity
Ariana M Chao, Molly Moore, Thomas A Wadden
Over the last century, hundreds of evaluations have been conducted to examine weight-management interventions related to diet, physical activity, and behavior therapy. These investigations have contributed to a growing body of knowledge that has consistently advanced the field of obesity treatment, while also revealing some persistent challenges. This narrative review summarizes key findings from randomized controlled trials conducted in adults that have combined diet, physical activity, and behavior therapy, an approach variously referred to as behavioral treatment, comprehensive lifestyle modification, or intensive lifestyle intervention...
April 27, 2024: International Journal of Obesity
Yongseop Lee, Sangmin Ahn, Min Han, Jung Ah Lee, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Se Hee Park, Jung Ho Kim
BACKGROUND: The obesity paradox suggests that individuals with obesity may have a survival advantage against specific critical illnesses, including sepsis. However, whether this paradox occurs at younger ages remains unclear. Therefore, we aimed to investigate whether obesity could improve survival in younger adult patients with sepsis. METHODS: We used clinical data sourced from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients with Sequential Organ Failure Assessment score ≥2 and suspected infection at the time of ICU admission were identified as having sepsis, following the Sepsis-3 definition...
April 26, 2024: International Journal of Obesity
Michal Kasher Meron, Sapir Eizenstein, Tali Cukierman-Yaffe, Dan Oieru
OBJECTIVE: To investigate whether individuals with an elevated BMI measurement, for whom a diagnosis of overweight or obesity (OW/OB) is not recorded, are less likely to be offered clinical care for obesity compared to those with a recorded diagnosis. SUBJECTS: A retrospective cohort study using the electronic medical record database of Maccabi Healthcare Services (MHS) in Israel. Included were 200,000 adults with BMI ≥ 25 kg/m2 measurement recorded during a primary care visit between 2014 and 2020, and no prior diagnosis of OW/OB or related co-morbidities...
April 22, 2024: International Journal of Obesity
Steven B Heymsfield
Knowledge of human body composition at the dawn of the twentieth century was based largely on cadaver studies and chemical analyses of isolated organs and tissues. Matters soon changed by the nineteen twenties when the Czech anthropologist Jindřich Matiegka introduced an influential new anthropometric method of fractionating body mass into subcutaneous adipose tissue and other major body components. Today, one century later, investigators can not only quantify every major body component in vivo at the atomic, molecular, cellular, tissue-organ, and whole-body organizational levels, but go far beyond to organ and tissue-specific composition and metabolite estimates...
April 20, 2024: International Journal of Obesity
Xue Xia, Xinsheng Han, Guangxin Xia, Xingquan Zhao, Anxin Wang
BACKGROUND: Obesity and metabolic syndrome (MetS) have been acknowledged to commonly co-exist and lead to increased risks of stroke, whereas the association between various BMI-based metabolic phenotypes and development of intracranial atherosclerotic stenosis (ICAS) remained controversial. METHODS: A total of 5355 participants were included from the Asymptomatic Polyvascular Abnormalities Community (APAC) study. Participants were categorized into six groups according to their body mass index (BMI) and MetS status...
April 18, 2024: International Journal of Obesity
Yuka Ishida, Mami Matsushita, Takeshi Yoneshiro, Masayuki Saito, Sayuri Fuse, Takafumi Hamaoka, Miyuki Kuroiwa, Riki Tanaka, Yuko Kurosawa, Takayuki Nishimura, Midori Motoi, Takafumi Maeda, Kazuhiro Nakayama
BACKGROUND: Sympathetic activation of brown adipose tissue (BAT) thermogenesis can ameliorate obesity and related metabolic abnormalities. However, crucial subtypes of the β-adrenergic receptor (AR), as well as effects of its genetic variants on functions of BAT, remains unclear in humans. We conducted association analyses of genes encoding β-ARs and BAT activity in human adults. METHODS: Single nucleotide polymorphisms (SNPs) in β1-, β2-, and β3-AR genes (ADRB1, ADRB2, and ADRB3) were tested for the association with BAT activity under mild cold exposure (19 °C, 2 h) in 399 healthy Japanese adults...
April 17, 2024: International Journal of Obesity
Marleigh Hefner, Gaurav Kudchadkar, Raksa Andalib Hia, Most Arifa Sultan, Holli Booe, Nikhil V Dhurandhar
No abstract text is available yet for this article.
April 17, 2024: International Journal of Obesity
Vinaysing Ramessur, Sadhna Hunma, Noorjehan Joonas, Bibi Nasreen Ramessur, Yves Schutz, Jean-Pierre Montani, Abdul G Dulloo
BACKGROUND/AIMS: Coronary heart disease morbidity and mortality are higher in people of South Asian origin than in those of African origin. We investigated whether as young adults without diabetes, people in Mauritius of South Asian descent (Indians) would show a more adverse cardiovascular risk profile that those of predominantly African descent (Creoles), and whether this could be explained by ethnic differences in visceral adiposity or other fat distribution patterns. METHODS: The study was conducted in 189 young non-physically active adults, with the following measurements conducted after an overnight fast: anthropometry (weight, height, waist circumference), whole-body and regional body composition by dual-energy x-ray absorptiometry, blood pressure, and blood assays for glycemic (glucose and HbA1c) and lipid profile (triglycerides and cholesterols)...
April 13, 2024: International Journal of Obesity
Julie Abildgaard, Anne Kirstine Bang, Loa Nordkap, Lærke Priskorn, Niels Jørgensen
BACKGROUND: Testosterone treatment is generally not recommended in men with obesity induced low serum testosterone. However, distinguishing this condition from overt testosterone deficiency in men with obesity where treatment should be initiated is a diagnostic challenge and tools to differentiate these conditions are scarce but could be of important clinical relevance. OBJECTIVES: To investigate the association between body composition and dynamic responses of the pituitary-testis axis in men...
April 12, 2024: International Journal of Obesity
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