Kathrin Gemesi, Stefanie Winkler, Susanne Schmidt-Tesch, Florian Schederecker, Hans Hauner, Christina Holzapfel
BACKGROUND: Despite an increasing number of smartphone applications (apps) addressing weight management, data on the effect of app-based multimodal obesity treatment approaches on weight loss is limited. This study aimed to examine the effect of a digital multimodal weight loss intervention program delivered by an app on body weight in persons with obesity. METHODS: For this single-centre randomized controlled study, 168 adults with a body mass index (BMI) between 30...
November 28, 2023: International Journal of Obesity
Peter J Rogers
No abstract text is available yet for this article.
November 27, 2023: International Journal of Obesity
Narek Sargsyan, Jun Yu Chen, Ravi Aggarwal, Michael G Fadel, Matyas Fehervari, Hutan Ashrafian
INTRODUCTION: Obesity is associated with alterations in cardiac structure and haemodynamics leading to cardiovascular mortality and morbidity. Culminating evidence suggests improvement of cardiac structure and function following bariatric surgery. OBJECTIVE: To evaluate the effect of bariatric surgery on cardiac structure and function in patients before and after bariatric surgery. METHODS: Systematic review and meta-analysis of studies reporting pre- and postoperative cardiac structure and function parameters on cardiac imaging in patients undergoing bariatric surgery...
November 25, 2023: International Journal of Obesity
Sreejon S Das, Swapan K Das
BACKGROUND: Obesity is a common disease with a higher prevalence among African Americans. Obesity alters cellular function in many tissues, including skeletal muscle, and is a risk factor for many life-threatening diseases, including cardiovascular disease and diabetes. The similarities and differences in molecular mechanisms that may explain ethnic disparities in obesity between African and European ancestry individuals have not been studied. METHODS: In this study, data from transcriptome-wide analyses on skeletal muscle tissues from well-powered human cohorts were used to compare genes and biological pathways affected by obesity in European and African ancestry populations...
November 22, 2023: International Journal of Obesity
Qingzhen He, Qingzhao Zheng, Houze Diao, Mingyuan Li, Qing Zhu, Fang Fang, Weiwei Cui
BACKGROUND: The Energy-Adjusted Dietary Inflammatory Index (E-DII) is related to both body mass index (BMI) and hyperuricemia. However, the association among BMI, hyperuricemia and DII is yet to be fully elucidated. The purpose of this study is to explore the role of BMI in the relationship between E-DII and hyperuricemia in the American population. METHODS: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016, with a sample size of 10,571 participants...
November 21, 2023: International Journal of Obesity
Camila Paixão Dos Santos, Antonio Viana do Nascimento-Filho, Amanda Aparecida Araujo, Danielle da Silva Dias, Deiwet Ribeiro Silva, Nathalia Bernardes, Tânia Plens Shecaira, Maria Cláudia Irigoyen, Kátia De Angelis
Fructose overconsumption is a worldwide trend, and it has been found to cause metabolic disorders in parents and their offspring. Additionally, metabolic syndrome has been closely associated with increased cardiovascular risk. In this study, we hypothesized that the chronic fructose consumption by parents could trigger autonomic dysfunction and cardiometabolic disorders in their offspring. Wistar rats undergo an intake of 10% of fructose in drinking water or regular water for 60 days before mating. Their offspring, control (C) and fructose (F) groups, were evaluated 30 days after weaning...
November 20, 2023: International Journal of Obesity
Yahui Ma, Lina Sun, Zhijing Mu
This network meta-analysis aimed to compare the efficacy of three forms of intermittent energy restriction (IER), including alternate-day fasting (ADF), the 5:2 diet, and time-restricted feeding (TRF), in overweight or obese adults. A literature search was conducted in PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) to find relevant randomized controlled trials (RCTs) until August 10, 2022. The modified Cochrane risk of bias assessment tool was applied to assess the methodological quality of eligible studies...
November 18, 2023: International Journal of Obesity
Fulei Han, Shuai Zhu, Xiangjie Kong, Weijing Wang, Yili Wu
BACKGROUND: Both genetic and epigenetic variations of GLP1R influence the development and progression of obesity. However, the underlying mechanism remains elusive. This study aims to explore the mediation roles of obesity-related methylation sites in GLP1R gene variants-obesity association. METHODS: A total of 300 Chinese adult participants were included in this study and classified into two groups: 180 metabolically healthy obesity (MHO) cases and 120 metabolically healthy normal-weight (MHNW) controls...
November 17, 2023: International Journal of Obesity
V V Sathibabu Uddandrao, Parim Brahma Naidu, P Chandrasekaran, G Saravanan
BACKGROUND: Obesity is a complex multifactorial disease in which the accumulation of excess body fat has adverse health effects, as it can increase the risk of several problems, including infertility, in both men and women. Obesity and infertility have risen together in recent years. Against this background, the present review aims to highlight the impact of obesity on infertility and the underlying pathophysiology of obesity-related infertility (ORI) in men and women, and to provide readers with knowledge of current trends in the effective development of phytotherapeutics for its treatment...
November 14, 2023: International Journal of Obesity
Tugba Barlas, Alev Eroglu Altinova, Mujde Akturk, Fusun Balos Toruner
BACKGROUND: The Chat Generative Pre-trained Transformer (ChatGPT) allows students, researchers, and patients in the medical field to access information easily and has gained attention nowadays. We aimed to evaluate the credibility of ChatGPT according to the guidelines for the assessment of obesity in type 2 diabetes (T2D), which is one of the major concerns of this century. MATERIALS AND METHOD: In this cross-sectional non-human subject study, experienced endocrinologists posed 20 questions to ChatGPT in subsections, which were assessments and different treatment options for obesity according to the American Diabetes Association and American Association of Clinical Endocrinology guidelines...
November 11, 2023: International Journal of Obesity
Hui Luo, Yesong Liu, Xue Tian, Yuhan Zhao, Lulu Liu, Zemeng Zhao, Lili Luo, Yanmin Zhang, Xiaozhong Jiang, Yeqiang Liu, Yanxia Luo, Anxin Wang
BACKGROUND: The association between obesity and cardiovascular disease (CVD) in people without traditional CVD risk factors is unclear. This study aimed to investigate the association of obesity with CVD and its subtypes in people without traditional CVD risk factors. METHODS: Based on the Kailuan cohort study, the included participants were divided into different groups according to levels of body mass index (BMI) and waist height ratio (WHtR), respectively. Multivariate Cox proportional hazard models were used to evaluate the associations...
November 8, 2023: International Journal of Obesity
Marcela Gomes Reis, Andrea J F Ferreira, Mohammad Hassan Sohouli, Diego Ribeiro Taimeirão, Renata Adrielle Lima Vieira, Nathalia Sernizon Guimarães
BACKGROUND: Obesity poses a significant public health challenge. Research has examined the impact of cannabis and subproducts on health but varying results have hindered a consensus. AIM: This study aimed to evaluated the effects of cannabis and subproducts on body measurements. METHODS: For searching randomized controlled trials evaluating cannabis and/or subproducts use and changes in anthropometric measures, a systematic search at MEDLINE, Embase, Cochrane Library and Web of Science was conducted until March 2023...
November 7, 2023: International Journal of Obesity
Marsha Dowda, Ruth P Saunders, Rod K Dishman, Russell R Pate
BACKGROUND/OBJECTIVES: Childhood obesity rates have increased in recent years. The effectiveness of future public health interventions to reduce childhood obesity will be enhanced by a better understanding of behavioral factors that influence adiposity in children as they transition from childhood to adolescence. The purpose of this study was to examine whether initial weight status modifies the longitudinal associations of physical activity, sedentary behavior, and diet quality with changes in adiposity over time...
November 6, 2023: International Journal of Obesity
Renata Moll-Bernardes, Juliana R Ferreira, Andréa Silvestre Sousa, Mariana B Tortelly, Adriana L Pimentel, Ana Cristina B S Figueiredo, Eduardo B Schaustz, José Carlos Pizzolante Secco, Allan Robson Kluser Sales, Flavia V O Terzi, Adriana Xavier de Brito, Renée O Sarmento, Marcia M Noya-Rabelo, Sergio Fortier, Flavia A Matos E Silva, Narendra Vera, Luciana Conde, Mauro Jorge Cabral-Castro, Denilson C Albuquerque, Paulo Rosado de-Castro, Gabriel C Camargo, Martha V T Pinheiro, Olga F Souza, Fernando A Bozza, Ronir R Luiz, Emiliano Medei
BACKGROUND: Comorbidities such as obesity, hypertension, and diabetes are associated with COVID-19 development and severity, probably due to immune dysregulation; however, the mechanisms underlying these associations are not clear. The immune signatures of hypertensive patients with obesity with COVID-19 may provide new insight into the mechanisms of immune dysregulation and progression to severe disease in these patients. METHODS: Hypertensive patients were selected prospectively from a multicenter registry of adults hospitalized with COVID-19 and stratified according to obesity (BMI ≥ 30 kg/m²)...
November 6, 2023: International Journal of Obesity
Giulia Cantini, Giovanni Quartararo, Niccolò Ghezzi, Diego Assis Gonçalves, Laura Fei, Arianna Pia Propato, Luca Galtarossa, Marcello Lucchese, Mario Maggi, Michaela Luconi
OBJECTIVE: Bariatric surgery not always results in satisfactory excess weight loss (EWL) in severe obesity. Given the economic and clinical costs of bariatric surgery failure, defining predictors of successful EWL represents a relevant clinical issue for the health system to select patients benefiting from operation. METHODS: By ELISA and Western blot analyses, we assessed the predicting value of pre-operative adiponectin (APN) locally produced in abdominal visceral (VAT) and subcutaneous (SAT) adipose tissue versus plasma levels as a novel sex-linked biomarker of EWL at different time points of follow up (6-24 months) after bariatric surgery in 43 patients (56% females) affected by severe obesity undergoing a small pilot observational study...
November 3, 2023: International Journal of Obesity
Joseph A Ladapo, Stephanie L Orstad, Judith Wylie-Rosett, Chi-Hong Tseng, Un Young Rebecca Chung, Nikhil R Patel, Suzanne B Shu, Noah J Goldstein, Soma Wali, Melanie Jay
BACKGROUND: The Financial Incentives for Weight Reduction (FIReWoRk) clinical trial showed that financial incentive weight-loss strategies designed using behavioral economics were more effective than provision of weight-management resources only. We now evaluate cost-effectiveness. METHODS: Cost-effectiveness analysis of a multisite randomized trial enrolling 668 participants with obesity living in low-income neighborhoods. Participants were randomized to (1) goal-directed incentives (targeting behavioral goals), (2) outcome-based incentives (targeting weight-loss), and (3) resources only, which were provided to all participants and included a 1-year commercial weight-loss program membership, wearable activity monitor, food journal, and digital scale...
November 3, 2023: International Journal of Obesity
Brianna Frangione, Sapriya Birk, Tarek Benzouak, Laura A Rodriguez-Villamizar, Fatima Karim, Rose Dugandzic, Paul J Villeneuve
INTRODUCTION: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are potentially obesogenic for children. We undertook a systematic review to synthesize this literature and explore sources of heterogeneity in previously published epidemiological studies. METHODS: Studies that collected individual-level PFAS and anthropometric data from children up to 12 years of age were identified by searching six databases. We excluded studies that only evaluated obesity measures at the time of birth...
October 31, 2023: International Journal of Obesity
Ankit Vyas, Rupak Desai, Advait Vasavada, Nitin Ghadge, Akhil Jain, Dishita Pandya, Carl J Lavie
BACKGROUND: Atrial fibrillation (AF) is an indicator of poor prognosis in patients with sepsis and can increase the risk of stroke and mortality. Data on the impact of severe obesity on the outcomes of sepsis complicated by AF remains poorly understood. METHODS: National Inpatient Sample (2018) and ICD-10 CM codes were used to identify the principal sepsis admissions with AF. We assessed comorbidities and outcomes of sepsis in people without obesity (BMI < 30) vs...
October 28, 2023: International Journal of Obesity
Jana Hoffmann, Jens Thiele, Stefan Kwast, Michael Andrew Borger, Thomas Schröter, Jochen Schmidt, Martin Busse
BACKGROUND: Visceral adipose tissue (VAT) has been linked to systemic proinflammatory characteristics, and measuring it accurately usually requires sophisticated instruments. This study aimed to estimate VAT applying a simpler method that uses total subcutaneous fat and total body fat (BF) measurements. METHOD: As part of our experimental approach, the subcutaneous fat mass (SFT) was measured via US (SFTtotal ), and VAT was quantified by assessing MRI data. Both parameters were added to obtain total body fat (BFcalc )...
October 27, 2023: International Journal of Obesity
Yuanyuan Zhang, Yanjun Zhang, Ziliang Ye, Chun Zhou, Sisi Yang, Mengyi Liu, Panpan He, Xiaoqin Gan, Xianhui Qin
OBJECTIVE: The prospective association between vitamin D and obstructive sleep apnea (OSA) remains uncertain. We aimed to assess the association between serum 25-hydroxyvitamin D (25(OH)D), a major circulating form of vitamin D, and new-onset OSA, and examine the modifying effect of obesity. MATERIALS AND METHODS: This prospective cohort study included 444,975 participants from UK Biobank without prior OSA. The primary outcome was new-onset OSA. RESULTS: During a median follow-up duration of 12...
October 27, 2023: International Journal of Obesity
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