Jin H Han, Adit A Ginde, Samuel M Brown, Adrienne Baughman, Erin M Collar, E Wesley Ely, Michelle N Gong, Aluko A Hope, Peter C Hou, Catherine L Hough, Theodore J Iwashyna, James C Jackson, Akram Khan, Onur M Orun, Mayur B Patel, Rameela Raman, Todd W Rice, Nancy Ringwood, Matthew W Semler, Nathan I Shapiro, Daniel S Talmor, Wesley H Self
BACKGROUND: Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. RESEARCH QUESTION: Does a single high-dose (540,000 IU) enteral treatment of vitamin D3 given shortly after hospital admission in vitamin D deficient, critically-ill patients improve long-term global cognition or executive function? STUDY DESIGN AND METHODS: This study evaluated long-term cognitive outcomes among patients enrolled in a multicenter, blinded, randomized clinical trial comparing vitamin D3 treatment versus placebo in critically-ill adults with vitamin D deficiency...
April 2, 2021: Chest