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Lewis B Morgenstern
No abstract text is available yet for this article.
May 17, 2019: Neurology
Roland Faigle, Lisa A Cooper, Rebecca F Gottesman
OBJECTIVE: We sought to determine whether the use of carotid revascularization procedures after stroke due to carotid stenosis differs between minority-serving hospitals and hospitals serving predominantly white patients. METHODS: We identified ischemic stroke cases due to carotid disease, identified by ICD-9-CM codes, from 2007 to 2011 in the Nationwide Inpatient Sample. The use of carotid endarterectomy (CEA) and carotid artery stenting (CAS) was recorded. Hospitals with ≥40% racial/ethnic minority patients (minority-serving hospitals) were compared to hospitals with <40% minority patients (predominantly white hospitals [hereafter, abbreviated to white])...
May 17, 2019: Neurology
Daniel Weber, Harini Sarva, Joshua Weaver, Fei Wang, Jingyuan Chou, Susannah Cornes, Katherine Nickels, Joseph E Safdieh, Ann Poncelet, Barney J Stern
In the current medical climate, medical education is at risk of being de-emphasized, leading to less financial support and compensation for faculty. A rise in compensation plans that reward clinical or research productivity fails to incentivize and threatens to erode the educational missions of our academic institutions. Aligning compensation with the all-encompassing mission of academic centers can lead to increased faculty well-being, clinical productivity, and scholarship. An anonymous survey developed by members of the A...
May 17, 2019: Neurology
Andrew G Herzog, Hannah B Mandle, Devon B MacEachern
OBJECTIVE: To determine (1) the proportion of women with epilepsy (WWE) at risk of unintended pregnancy who use highly effective contraception, (2) demographic predictors, and (3) folic acid (FA) use. METHODS: These cross-sectional data come from 311 US WWE, 18-47 years, who participated in the Epilepsy Birth Control Registry (EBCR) web-based survey in 2017. They provided demographic, epilepsy, antiepileptic drug (AED), contraceptive, and FA data. We report frequencies of highly effective contraception use and use logistic regression to determine demographic predictors...
May 17, 2019: Neurology
Giulia Giannini, Matthieu Francois, Eugénie Lhommée, Mircea Polosan, Emmanuelle Schmitt, Valérie Fraix, Anna Castrioto, Claire Ardouin, Amélie Bichon, Pierre Pollak, Alim-Louis Benabid, Eric Seigneuret, Stephan Chabardes, Maxime Wack, Paul Krack, Elena Moro
OBJECTIVE: To determine the postoperative attempted and completed suicide rates after subthalamic nucleus deep brain stimulation (STN-DBS) in a single-center cohort and to determine factors associated with attempted and completed suicide. METHODS: We retrospectively included all patients with Parkinson disease (PD) who underwent bilateral STN-DBS surgery at the Grenoble University Hospital between 1993 and 2016. For each patient who committed or attempted suicide, 2 patients with PD with STN-DBS without any suicidal behaviors were matched for age (±1 year), sex, and year of surgery (±2 years)...
May 17, 2019: Neurology
Claudio Baracchini, Filippo Farina, Anna Palmieri, Caterina Kulyk, Alessio Pieroni, Federica Viaro, Giacomo Cester, Francesco Causin, Renzo Manara
OBJECTIVE: To find early hemodynamic predictors of outcome and reperfusion injury in patients with acute ischemic stroke due to anterior circulation large artery occlusion (LAO) after endovascular treatment (EVT). METHODS: Serial transcranial color-coded sonography examinations assessed the vessel status and cerebral hemodynamics of 185 (109 [58.9%] men, mean age 69.5 ± 12.3 years) consecutive patients with acute anterior circulation LAO soon after, at 48 hours after, and 1 week after EVT...
May 15, 2019: Neurology
Allison S Young, Corinna Lechner, Andrew P Bradshaw, Hamish G MacDougall, Deborah A Black, G Michael Halmagyi, Miriam S Welgampola
OBJECTIVE: To facilitate the diagnosis of vestibular disorders by patient-initiated capture of ictal nystagmus. METHODS: Adults from an Australian neurology outpatient clinic reporting recurrent vertigo were recruited prospectively and taught to self-record spontaneous and positional nystagmus at home while symptomatic, using miniature video-oculography goggles. Consenting patients with ictal videorecordings and a final unblinded clinical diagnosis of Ménière disease (MD), vestibular migraine (VM), or benign paroxysmal positional vertigo (BPPV) were included...
May 15, 2019: Neurology
Matthew B Maas, Gregory Kapinos
No abstract text is available yet for this article.
May 15, 2019: Neurology
Kyla A McKay, Jan Hillert, Ali Manouchehrinia
OBJECTIVE: To evaluate long-term disability progression in pediatric-onset multiple sclerosis (POMS) and compare to adult-onset multiple sclerosis (AOMS). METHODS: This was a retrospective cohort study using prospectively collected clinical information from the Swedish MS Registry. Clinical features were compared and Kaplan-Meier and Cox proportional hazards regression were used to assess the risk of reaching sustained Expanded Disability Status Scale (EDSS) 3, 4, and 6 in POMS (multiple sclerosis [MS] onset <18 years) and AOMS (MS onset ≥18 years)...
May 15, 2019: Neurology
Vasileios Papavasileiou, Larry B Goldstein
No abstract text is available yet for this article.
May 15, 2019: Neurology
Jodi A Dodds, Ying Xian, Shubin Sheng, Gregg C Fonarow, Deepak L Bhatt, Roland Matsouaka, Lee H Schwamm, Eric D Peterson, Eric E Smith
OBJECTIVE: To determine whether young adults (≤40 years old) with acute ischemic stroke are less likely to receive IV tissue plasminogen activator (tPA) and more likely to have longer times to brain imaging and treatment. METHODS: We analyzed data from the Get With The Guidelines-Stroke registry for acute ischemic stroke patients hospitalized between January 2009 and September 2015. We used multivariable models with generalized estimating equations to evaluate tPA treatment and outcomes between younger (age 18-40 years) and older (age >40 years) acute ischemic stroke patients...
May 15, 2019: Neurology
Kevin Vallotton, Eveline Huber, Reto Sutter, Armin Curt, Markus Hupp, Patrick Freund
OBJECTIVE: To assess whether preserved dorsal and ventral midsagittal tissue bridges after traumatic cervical spinal cord injury (SCI) encode tract-specific electrophysiologic properties and are predictive of appropriate recovery. METHODS: In this longitudinal study, we retrospectively assessed MRI scans at 1 month after SCI that provided data on width and location (dorsal vs ventral) of midsagittal tissue bridges in 28 tetraplegic patients. Regression analysis assessed associations between midsagittal tissue bridges and motor- and sensory-specific electrophysiologic recordings and appropriate outcome measures at 12 months after SCI...
May 15, 2019: Neurology
Yiheng Tu, Zening Fu, Fang Zeng, Nasim Maleki, Lei Lan, Zhengjie Li, Joel Park, Georgia Wilson, Yujie Gao, Mailan Liu, Vince Calhoun, Fanrong Liang, Jian Kong
OBJECTIVE: To investigate the dynamic functional connectivity of thalamo-cortical networks in interictal migraine patients and whether clinical features are associated with abnormal connectivity. METHODS: We investigated dynamic functional network connectivity (dFNC) of the migraine brain in 89 interictal migraine patients and 70 healthy controls. We focused on the temporal properties of thalamocortical connectivity using sliding window cross-correlation, clustering state analysis, and graph-theory methods...
May 10, 2019: Neurology
Martha Nowosielski, Thierry Gorlia, Jacoline E C Bromberg, Felix Sahm, Inga Harting, Philipp Kickingereder, Alba A Brandes, Martin J B Taphoorn, Walter Taal, Julien Domont, Ahmed Idbaih, Mario Campone, Paul M Clement, Michael Weller, Michel Fabbro, Emilie Le Rhun, Michael Platten, Vassilis Golfinopoulos, Martin J van den Bent, Martin Bendszus, Wolfgang Wick
OBJECTIVE: Imaging necrosis on MRI scans was assessed and compared to outcome measures of the European Organisation for Research and Treatment of Cancer 26101 phase III trial that compared single-agent lomustine with lomustine plus bevacizumab in patients with progressive glioblastoma. METHODS: MRI in this post hoc analysis was available for 359 patients (lomustine = 127, lomustine + bevacizumab = 232). First, imaging necrosis at baseline being formally measurable (>10 × 10 mm, given 2 slices) was assessed...
May 10, 2019: Neurology
Edith Nobels-Janssen, Philip J van der Wees, Wim I M Verhagen, Gert P Westert, Ronald H M A Bartels, Jeroen D Boogaarts
OBJECTIVE: Patient-reported outcomes (PROs) are aspects of a patient's health status and are considered important for stimulating patient-centered care. Current outcome measures in clinical care for patients with aneurysmal subarachnoid hemorrhage (aSAH) are insufficient to capture PROs. In this systematic review, we aimed to summarize the evidence regarding the quality of patient-reported outcome measures (PROMs) in aSAH patients. METHODS: We performed a systematic review of the literature published from inception until October 29, 2018, in PubMed, the Cochrane Central Register of Controlled Trials, and EMBASE...
May 10, 2019: Neurology
Konark Malhotra, Muhammad F Ishfaq, Nitin Goyal, Aristeidis H Katsanos, John Parissis, Anne W Alexandrov, Andrei V Alexandrov, Georgios Tsivgoulis
OBJECTIVE: Data regarding the efficacy and safety of warfarin and non-vitamin K antagonist oral anticoagulant (NOAC) among patients with chronic kidney disease (CKD) remain scarce. METHODS: Systematic review and meta-analysis of studies involving patients with CKD treated with oral anticoagulants were conducted to evaluate the following outcomes: ischemic stroke, intracerebral hemorrhage (ICH), combined ischemic and hemorrhagic stroke (strokecombined ), stroke or systemic embolism, mortality, and major bleeding events...
May 8, 2019: Neurology
Giulia Coarelli, Rebecca Schule, Bart P C van de Warrenburg, Peter De Jonghe, Claire Ewenczyk, Andrea Martinuzzi, Matthis Synofzik, Elisa G Hamer, Jonathan Baets, Mathieu Anheim, Ludger Schöls, Tine Deconinck, Pegah Masrori, Bertrand Fontaine, Thomas Klockgether, Maria Grazia D'Angelo, Marie-Lorraine Monin, Jan De Bleecker, Isabelle Migeotte, Perrine Charles, Maria Teresa Bassi, Thomas Klopstock, Fanny Mochel, Elisabeth Ollagnon-Roman, Marc D'Hooghe, Christoph Kamm, Delia Kurzwelly, Melanie Papin, Claire-Sophie Davoine, Guillaume Banneau, Sophie Tezenas du Montcel, Danielle Seilhean, Alexis Brice, Charles Duyckaerts, Giovanni Stevanin, Alexandra Durr
OBJECTIVE: We took advantage of a large multinational recruitment to delineate genotype-phenotype correlations in a large, trans-European multicenter cohort of patients with spastic paraplegia gene 7 ( SPG7 ). METHODS: We analyzed clinical and genetic data from 241 patients with SPG7 , integrating neurologic follow-up data. One case was examined neuropathologically. RESULTS: Patients with SPG7 had a mean age of 35.5 ± 14.3 years (n = 233) at onset and presented with spasticity (n = 89), ataxia (n = 74), or both (n = 45)...
May 8, 2019: Neurology
Craig A Press, Kevin E Chapman
No abstract text is available yet for this article.
May 8, 2019: Neurology
Foad Taghdiri, Namita Multani, Apameh Tarazi, Seyed Ali Naeimi, Mozghan Khodadadi, Carrie Esopenko, Robin Green, Brenda Colella, Richard Wennberg, David Mikulis, Karen Deborah Davis, Ruma Goswami, Charles Tator, Brian Levine, Maria Carmela Tartaglia
OBJECTIVE: To identify CSF biomarkers that are related to decreased white matter (WM) integrity and poor cognitive performance in former professional athletes with a history of multiple concussions. METHODS: Concentrations of phosphorylated tau181, total tau (t-tau), and β-amyloid in the CSF were measured in 3 groups: 22 former professional athletes with multiple concussions (mean ± SD age 55.9 ± 12.2 years), 5 healthy controls (age 57.4 ± 5.2 years), and 12 participants (age 60...
May 8, 2019: Neurology
Lisa Vermunt, Alegría J L van Paasen, Charlotte E Teunissen, Philip Scheltens, Pieter Jelle Visser, Betty M Tijms
OBJECTIVE: To identify potential predictors for outcome in individuals with mild cognitive impairment (MCI) who have reverted to normal cognition (NC). METHODS: We selected individuals with MCI, who reverted at follow-up to NC, with follow-up after reversion from Alzheimer's Disease Neuroimaging Initiative. Common clinical markers, Alzheimer disease (AD) biomarkers, and neurodegeneration imaging markers were used to compare MCI reverters based on subsequent clinical outcome (i...
May 8, 2019: Neurology
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