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Anke Wouters, Lauranne Scheldeman, Sam Plessers, Ronald Peeters, Sarah Cappelle, Philippe Demaerel, Wim Van Paesschen, Bert Ferdinande, Matthias Dupont, Jo Dens, Stefan Janssens, Koen Ameloot, Robin Lemmens
OBJECTIVE: To test the prognostic value of brain MRI in addition to clinical and electrophysiological variables in post-cardiac arrest (CA) patients, we explored data from the randomized Neuroprotect post-CA trial (NCT02541591). METHODS: In this trial brain MRI's were prospectively obtained. We calculated receiver operating characteristic curves for the average Apparent Diffusion Coefficient (ADC) value and percentage of brain voxels with an ADC value < 650 x 10-6 mm2 /s and < 450 x 10-6 mm2 /s...
April 9, 2021: Neurology
#2
Vincenzo Donadio, Zerui Wang, Alex Incensi, Giovanni Rizzo, Enrico Fileccia, Veria Vacchiano, Sabina Capellari, Martina Magnani, Cesa Scaglione, Michelangelo Stanzani Maserati, Patrizia Avoni, Rocco Liguori, Wenquan Zou
OBJECTIVE: To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in distinguish synucleinopathies (SOPs) from non-synucleinopathies (non-SOPs) in a large cohort of patients. METHODS: We prospectively recruited 90 patients fulfilling clinical and instrumental diagnostic criteria for all SOPs variants and non-SOPs (mainly including Alzheimer disease, tauopathies, and vascular parkinsonism or dementia)...
April 9, 2021: Neurology
#3
Daniel Sánchez-Tejerina, Luísa Panadés-de Oliveira, Miguel A Martín, María I Álvarez-Mora, Aurelio Hernández-Lain, Cristina Domínguez-González
No abstract text is available yet for this article.
April 9, 2021: Neurology
#4
William Szurhaj, Alexandre Leclancher, Anca Nica, Bertille Périn, Philippe Derambure, Philippe Convers, Laure Mazzola, Bertrand Godet, Marie Faucanie, Marie-Christine Picot, Julien De Jonckheere
OBJECTIVE: We aimed to test whether patients who died from sudden unexpected death in epilepsy (SUDEP) had an abnormal cardiac autonomic response to sympathetic stimulation by hyperventilation. METHODS: We conducted a retrospective, observational, case-control study of a group of patients who died from SUDEP and controls who were matched with the patients for epilepsy type, drug resistance, sex, age at electroencephalogram recording, age at onset of epilepsy, and duration of epilepsy...
April 9, 2021: Neurology
#5
Gihwan Byeon, Gyu Han Oh, Jin Hyeong Jhoo, Jae-Won Jang, Jong Bin Bae, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Dong Young Lee, Ki Woong Kim
OBJECTIVE: To investigate the effects of single sensory impairment (SSI; visual or auditory) or dual sensory impairment (DSI; visual and auditory) on dementia and longitudinal changes of neuropsychological test scores. METHODS: In this nationwide, prospective, community-based elderly cohort study, Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), 6,520 elderly individuals (58-101 year) representing the general population were included. We defined visual and auditory sensory impairment via self-report questionnaire: 932 had a normal sensory function, 2957 had a SSI, and 2631 had a DSI...
April 7, 2021: Neurology
#6
Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Christopher S Walker, Debbie L Hay, Messoud Ashina
ObjectiveTo determine whether the intravenous infusion of adrenomedullin, a potent vasodilator belonging to calcitonin family of peptides, provokes attacks of migraine in patients.MethodsTwenty migraine without aura patients participated in a placebo-controlled and double-blinded clinical study. In a randomized and crossover design the patients received an intravenous infusion of human adrenomedullin (19.9 picomole/kg/min) or placebo (saline) administrated via an automated intravenous pump (20 minutes). The patients participated in two study days with washout period of minimum of seven days...
April 7, 2021: Neurology
#7
Jeffrey Lambe, Hunter Risher, Angeliki G Filippatou, Olwen C Murphy, Elias S Sotirchos, Henrik Ehrhardt, Esther Ogbuokiri, Nicole Pellegrini, Brandon Toliver, Nicholas J Luciano, Simidele Davis, Nicholas Fioravante, Ohemaa Kwakyi, Jerry L Prince, Peter A Calabresi, Kathryn C Fitzgerald, Shiv Saidha
OBJECTIVE: To investigate the effects of rituximab on retinal atrophy in patients with relapsing-remitting multiple sclerosis (RRMS), we performed serial optical coherence tomography (OCT) scans among a cohort of RRMS patients on rituximab, and compared rates of ganglion cell+inner plexiform layer (GCIPL) atrophy to those observed among age- and sex-matched glatiramer acetate (GA)- and natalizumab-treated RRMS patients, and healthy controls (HCs). METHODS: In this observational study, patients with RRMS treated with a single disease-modifying therapy, and HCs, were followed with serial OCT for a median duration of 2...
April 7, 2021: Neurology
#8
Liisa Karjalainen, Minna Tikkanen, Kirsi Rantanen, Karoliina Aarnio, Aino Korhonen, Anna Saaros, Hannele Laivuori, Mika Gissler, Petra Ijäs
OBJECTIVE: To investigate whether previously reported increasing incidence of pregnancy-associated stroke (PAS) is observed in chart-validated register data in Finland. In an exploratory analysis, we studied risk factors for PAS. METHODS: We performed a retrospective population-based cohort study and nested case-control study in Finland 1987-2016. The Medical Birth Register (MBR) was linked with the Hospital Discharge Register to identify women with incident stroke (ischemic stroke, cerebral venous thrombosis, intracerebral or subarachnoid hemorrhage) during pregnancy or puerperium...
April 7, 2021: Neurology
#9
Julio C Rojas, Ping Wang, Adam M Staffaroni, Carolin Heller, Yann Cobigo, Amy Wolf, Sheng-Yang M Goh, Peter A Ljubenkov, Hilary W Heuer, Jamie C Fong, Joanne B Taylor, Eliseo Veras, Linan Song, Andreas Jeromin, David Hanlon, Lili Yu, Arvind Khinikar, Rajeev Sivasankaran, Agnieszka Kieloch, Marie-Anne Valentin, Anna M Karydas, Laura L Mitic, Rodney Pearlman, John Kornak, Joel H Kramer, Bruce L Miller, Kejal Kantarci, David S Knopman, Neill Graff-Radford, Leonard Petrucelli, Rosa Rademakers, David J Irwin, Murray Grossman, Eliana Marisa Ramos, Giovanni Coppola, Mario F Mendez, Yvette Bordelon, Bradford C Dickerson, Nupur Ghoshal, Edward D Huey, Ian R Mackenzie, Brian S Appleby, Kimiko Domoto-Reilly, Ging-Yuek R Hsiung, Arthur W Toga, Sandra Weintraub, Daniel I Kaufer, Diana Kerwin, Irene Litvan, Chiadikaobi U Onyike, Alexander Pantelyat, Erik D Roberson, Maria C Tartaglia, Tatiana Foroud, Weiping Chen, Julie Czerkowicz, Danielle L Graham, John C van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B Rowe, Mario Masellis, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris R Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, David M Cash, Rhian S Convery, Martina Bocchetta, Martha Foiani, Greaves Caroline V, Georgia Peakman, Lucy Russell, Imogen Swift, Emily Todd, Jonathan D Rohrer, Bradley F Boeve, Howard J Rosen, Adam L Boxer
OBJECTIVE: We tested the hypothesis that plasma neurofilament light chain (NfL) identifies asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk of disease progression. METHODS: Baseline plasma NfL concentrations were measured with Simoa in original (n = 277) and validation (n = 297) cohorts. C9orf72 , GRN and MAPT mutation carriers and non-carriers from the same families were classified by disease severity [asymptomatic, prodromal and full phenotype] using the CDR® Dementia Staging Instrument plus behavior and language domains from the National Alzheimer's Disease Coordinating Center FTLD module (CDR® +NACC-FTLD)...
April 7, 2021: Neurology
#10
EDITORIAL
Ahmed T Toosy, Kush Kapur, Kavita V Nair
No abstract text is available yet for this article.
April 7, 2021: Neurology
#11
Mana Higashihara, Nathan Pavey, Mehdi van den Bos, Parvathi Menon, Matthew C Kiernan, Steve Vucic
OBJECTIVE: To determine whether cortical hyperexcitability was more prominent in cognitively impaired amyotrophic lateral sclerosis (ALS) patients. METHODS: Threshold tracking transcranial magnetic stimulation (TMS) was utilised to assess cortical excitability, while cognitive function determined by the Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Cognitive impairment was defined by ECAS<105. ALS patients, defined by the Awaji criteria, were prospectively recruited...
April 7, 2021: Neurology
#12
Tamara M Pringsheim, Nicholas Cothros, Emmanuel Roze
No abstract text is available yet for this article.
April 7, 2021: Neurology
#13
Sun Min Lee, Yong Jun Choi, Kihwang Lee, Hyeung Kyoo Kim, Jin-Sun Park, Yong Cheol Lim, Jang-Hee Kim, So Young Moon
No abstract text is available yet for this article.
April 7, 2021: Neurology
#14
EDITORIAL
Eliza C Miller, Lisa Leffert
No abstract text is available yet for this article.
April 7, 2021: Neurology
#15
EDITORIAL
Dennis Bourdette, Joep Killestein
No abstract text is available yet for this article.
April 6, 2021: Neurology
#16
Alejandra M Márquez Loza, Kathryn B Holroyd, Stephen A Johnson, David M Pilgrim, Anthony A Amato
No abstract text is available yet for this article.
April 6, 2021: Neurology
#17
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2021: Neurology
#18
Yanjun Guo, Pamela M Rist, Maria Sabater Lleal, Paul de Vries, Nicholas Smith, Paul M Ridker, Tobias Kurth, Daniel Chasman
OBJECTIVE: To assess support for a causal relationship between hemostatic measures and migraine susceptibility using genetic instrumental analysis. METHODS: Two-sample Mendelian randomization (MR) instrumental leveraging available genome-wide association study (GWAS) summary statistics was applied to hemostatic measures as potential causal for migraine and its subtypes, migraine with aura (MA) and migraine without aura (MO). Twelve blood-based measures of hemostasis were examined, including plasma level or activity of eight hemostatic factors and two fibrinopeptides together with two hemostasis clinical tests...
April 1, 2021: Neurology
#19
Justin J Grassmeyer, J Americo Fernandes, Jason T Helvey, Sachin Kedar
No abstract text is available yet for this article.
April 1, 2021: Neurology
#20
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2021: Neurology
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