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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 24, 2023: Neurology
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JOURNAL ARTICLE
Longting Lin, Hao Zhang, Feifeng Liu, Chen Chen, Chushuang Chen, Andrew Bivard, Mark W Parsons, Gang Li
BACKGROUND AND OBJECTIVES: It is still uncertain that going direct to endovascular thrombectomy (EVT) leads to equivalent outcomes as bridging intravenous thrombolysis (IVT) in acute ischemic patients. This study aimed to explore whether the rate of ischemic core growth influenced the patient outcomes after bridging IVT vs. direct EVT. METHODS: This was a retrospective cohort study based on the International Stroke Perfusion Imaging Registry (INSPIRE). It selected acute ischemic stroke patients receiving perfusion CT within 4...
March 24, 2023: Neurology
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JOURNAL ARTICLE
Mickaël Ferrand, Cédric Baumann, Olivier Aron, Jean-Pierre Vignal, Jacques Jonas, Louise Tyvaert, Sophie Colnat-Coulbois, Laurent Koessler Doctor, Louis Maillard
BACKGROUND AND OBJECTIVES: It remains unknown to what extent ictal scalp EEG can accurately predict the localization of the intra-cerebral seizure onset in pre-surgical evaluation of drug resistant epilepsies. In this study, we aimed to define homogeneous ictal scalp EEG profiles (based on their first ictal abnormality) and assess their localizing value using simultaneously recorded scalp EEG and Stereo-EEG. METHODS: We retrospectively included consecutive patients with drug-resistant focal epilepsy who had simultaneous stereo-EEG and scalp EEG recordings of at least one seizure, in the epileptology unit in Nancy, France...
March 24, 2023: Neurology
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JOURNAL ARTICLE
Wei-En Johnny Tseng, Chun-Wei Chang, Jawl-Shan Hwang, Po-Chuan Ko, Chun-Jing Liu, Siew-Na Lim
BACKGROUND: and ObjectivesDiabetes mellitus (DM) contributes significantly to the metabolic syndrome and cardiovascular events, and it may be a comorbidity of epilepsy. The objective of this study was to investigate whether long-term antiseizure medication (ASM) use is associated with the risk of developing type 2 diabetes.MethodsWe analyzed data from the Chang Gung Research Database. Patients aged ≥ 45 years who received ASM treatment from January 2001 to May 2019 were identified...
March 24, 2023: Neurology
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JOURNAL ARTICLE
Michelle P Lin, Bhrugun Anisetti
No abstract text is available yet for this article.
March 24, 2023: Neurology
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JOURNAL ARTICLE
Aileen McGonigal
No abstract text is available yet for this article.
March 24, 2023: Neurology
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JOURNAL ARTICLE
Tian Xiao, Samuel Ghatan, Sanne S Mooldijk, Katerina Trajanoska, Ling Oei, M Medina Gomez, M Kamran Ikram, Fernando Rivadeneira, M Arfan Ikram
BACKGROUND: & Objective: Low bone mineral density and dementia commonly co-occur in the elderly, with bone loss accelerating in dementia patients due to physical inactivity and poor nutrition. However, uncertainty persists over the extent to which bone loss already exists prior to the onset of dementia. Therefore, we investigated how dementia risk was affected by bone mineral density at various skeletal regions in community-dwelling older adults. METHODS: In a prospective population-based cohort study, bone mineral density at the femoral neck, lumbar spine, and total body and the trabecular bone score were obtained using dual-energy X-ray absorptiometry (DXA) in 3,651 participants free from dementia between 2002-2005...
March 22, 2023: Neurology
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JOURNAL ARTICLE
Matthew Pease, Arka N Mallela, Jonathan Elmer, David O Okonkwo, Lori Shutter, Niravkumar Barot, Jorge Gonzalez-Martinez, James F Castellano
OBJECTIVE: Nearly one-third of severe traumatic brain injury (TBI) patients develop post-traumatic epilepsy (PTE). The relationship between PTE and long-term outcomes is unknown. We tested if, after controlling for injury severity and age, PTE is associated with worse functional outcomes after severe TBI. METHODS: We performed a retrospective analysis of a prospective database of severe TBI patients treated from 2002 through 2018 at a single level 1 trauma center...
March 22, 2023: Neurology
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JOURNAL ARTICLE
Hye-Jin Moon, Hyesung Lee, Dongwon Yoon, Yong Seo Koo, Ju-Young Shin, Seo-Young Lee
BACKGROUND AND OBJECTIVES: People with epilepsy (PWE) are at risk of premature death with considerable variability according to the study population. We aimed to estimate the risk and causes of death in PWE according to age, disease severity, disease course, comorbidities and socioeconomic status in Korea. METHODS: We conducted a nationwide population-based retrospective cohort study using the National Health Insurance database linked with the national death register...
March 22, 2023: Neurology
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JOURNAL ARTICLE
Serena Zampino, Farooq H Sheikh, Joban Vaishnav, Daniel Judge, Baohan Pan, Amrita Daniel, Emily Brown, Gigi Ebenezer, Michael Polydefkis
BACKGROUND AND OBJECTIVES: hATTR is a rare autosomal-dominant systemic disease with variable penetrance and heterogeneous clinical presentation. Several effective treatments can reduce mortality and disability, though diagnosis remains challenging, especially in the US where disease is non-endemic. Our aim is to describe the neurologic and cardiac characteristics of common US ATTR variants V122I, L58H and late-onset V30M at presentation. METHODS: We conducted a retrospective case series of patients with a new diagnosis of ATTRv between January 2008 and January 2020 to characterize features of prominent US variants The neurological (examination, EMG, skin biopsy), cardiac (echo) and laboratory assessments (proBNP, reversible neuropathy screens) are described...
March 20, 2023: Neurology
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JOURNAL ARTICLE
Hongfei Sang, Dongjing Xie, Yan Tian, Thanh N Nguyen, Jeffrey L Saver, Raul G Nogueira, Junxiong Wu, Chen Long, Zhenxuan Tian, Zhizhou Hu, Tao Wang, Rongzong Li, Yingbing Ke, Xiurong Zhu, Daizhou Peng, Mingze Chang, Lingfei Li, Jie Ruan, Deping Wu, Wenjie Zi, Qingwu Yang, Fengli Li, Zhongming Qiu
OBJECTIVE: To investigate the efficacy and safety of intravenous infusion of tirofiban before endovascular thrombectomy for patients with large vessel occlusion due to intracranial atherosclerotic disease. The secondary objective was to identify potential mediators for the clinical effect of tirofiban. METHODS: Post hoc exploratory analysis of the Endovascular Treatment With versus Without Tirofiban for Patients with Large Vessel Occlusion Stroke (RESCUE BT) trial, which was a randomized, double-blinded, placebo-controlled trial at 55 centers in China from October 2018 to October 2021...
March 20, 2023: Neurology
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JOURNAL ARTICLE
Brian Nils Lundstrom, Nicholas M Gregg
No abstract text is available yet for this article.
March 20, 2023: Neurology
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JOURNAL ARTICLE
Elle Levit, Janice Leon, Matthew Lincoln
A 36-year-old man who presented multiple times with fever, headache, alteration of mental status, and focal neurological deficits. MRI revealed extensive white matter lesions that were partially reversed between episodes. Workup revealed persistently low complement factor C3, low factor B, and absent alternative complement pathway activity. Biopsy revealed neutrophilic vasculitis. Genetic testing revealed a homozygous mutation in complement factor I (CFI), that was felt to be pathogenic. CFI regulates complement mediated inflammation, and deficiency in this factor leads to unchecked alternative pathway activity and decrease in C3 and factor B through consumption...
March 20, 2023: Neurology
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JOURNAL ARTICLE
Rachel M Butler Pagnotti, Shehroo B Pudumjee, Chad L Cross PStat R C-Mdi, Justin B Miller Abpp-Cn
BACKGROUND AND OBJECTIVES: Limbic predominant age related TDP-43 (LATE) impacts similar neuroanatomical networks as Alzheimer's disease (AD) and is often comorbid with AD, though frequently missed in clinical diagnosis. The primary aim of this study was to elucidate the clinical and cognitive differences at baseline between patients with autopsy confirmed LATE, compared to patients with AD and comorbid LATE+AD. METHODS: Clinical and neuropathological datasets were requested from the National Alzheimer's Coordination Center (NACC)...
March 20, 2023: Neurology
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JOURNAL ARTICLE
Anthipa Chokesuwattanaskul, Maria Clara Zanon Zotin, Dorothée Schoemaker, Lukas Sveikata, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
ObjectiveTo analyze the prevalence and associated clinical characteristics of apathy in sporadic cerebral amyloid angiopathy and investigate whether apathy was associated with disease burden and disconnections of key structures in the reward circuit through a structural and functional multi-modal neuroimaging approach.MethodsThirty-seven probable sporadic cerebral amyloid angiopathy participants without symptomatic intracranial hemorrhage or dementia (mean age, 73.3 ± 7.2, % male = 59.5%) underwent a detailed neuropsychological evaluation, including measures of apathy and depression, and a multimodal MR neuroimaging study...
March 20, 2023: Neurology
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JOURNAL ARTICLE
Misfolded α-Synuclein Assessment in Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder.
Alex Iranzo, Angela Mammana, Amaia Muñoz-Lopetegi, Sofia Dellavalle, Gerard Mayà, Marcello Rossi, Monica Serradell, Simone Baiardi, Aurora Arqueros, Corinne Quadalti, Andres Perissinotti, Edoardo Ruggeri, Joan Santamaria Cano, Carles Gaig, Piero Parchi
BACKGROUND AND OBJECTIVES: Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify misfolded α-synuclein in the skin and CSF of IRBD patients. METHODS: Cross-sectional study where consecutive patients with polysomnographic-confirmed IRBD and age-matched controls without RBD underwent skin biopsy and lumbar puncture the same day...
March 17, 2023: Neurology
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JOURNAL ARTICLE
Paride Schito, Tommaso Russo, Teuta Domi, Alessandra Mandelli, Laura Pozzi, Ubaldo Del Carro, Paola Carrera, Federica Agosta, Angelo Quattrini, Roberto Furlan, Massimo Filippi, Nilo Riva
BACKGROUND: Differentiation between primary (PLS) and amyotrophic lateral sclerosis (ALS) entails relevant consequences for prognosis and management but is mostly unreliable at early stages. The objectives of the study are: i) to determine the features at onset that could help to differentiate between PLS and ALS; ii) to evaluate the diagnostic performance of an integrated serum biomarker panel; iii) to identify the prognostic factors for patients presenting with an upper motor neuron (UMN)-syndrome...
March 16, 2023: Neurology
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JOURNAL ARTICLE
Navkiranjot Kaur, Amy S Nowacki, Deepak K Lachhwani, Madison M Berl, Marla J Hamberger, Patricia Klaas, William Bingaman, Robyn M Busch
OBJECTIVES: To (1) characterize short-term outcomes in episodic memory, as assessed by the Children's Memory Scale (CMS), following temporal lobe resection in children with epilepsy using empirical methods for assessing cognitive change (i.e., reliable change indices: RCIs and standardized regression-based change scores: SRBs) and (2) develop and internally validate clinically-applicable models to predict postoperative memory decline. METHODS: This retrospective cohort study included children aged 6-16 years who underwent resective epilepsy surgery that included the temporal lobe (temporal-only: "temporal" and multilobar: "temporal-plus") and who completed pre- and postoperative neuropsychological assessments including the CMS...
March 16, 2023: Neurology
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JOURNAL ARTICLE
Yuankai Zhang, Xue Liu, Kerri L Wiggins, Nuzulul Kurniansyah, Xiuqing Guo, Amanda L Rodrigue, Wei Zhao, Lisa R Yanek, Scott M Ratliff, Achilleas Pitsillides, Juan Sebastian Aguirre Patiño, Tamar Sofer, Dan E Arking, Thomas R Austin, Alexa S Beiser, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E Curran, Lifang Hou, Timothy M Hughes, Sharon L Kardia, Lenore Launer, Daniel Levy, Tom H Mosley, Ilya M Nasrallah, Stephen S Rich, Jerome I Rotter, Sudha Seshadri, Wassim Tarraf, Kevin A González, Vasan Ramachandran, Kristine Yaffe, Paul A Nyquist, Bruce M Psaty, Charles S DeCarli, Jennifer A Smith, David C Glahn, Hector M González, Joshua C Bis, Myriam Fornage, Susan R Heckbert, Annette L Fitzpatrick, Chunyu Liu, Claudia L Satizabal
BACKGROUND AND OBJECTIVES: Previous studies suggest lower mitochondrial DNA (mtDNA) copy number (CN) is associated with neurodegenerative diseases. However, whether mtDNA CN in whole blood is related to endophenotypes of Alzheimer's disease (AD) and AD related dementia (AD/ADRD) needs further investigation. We assessed the association of mtDNA CN with cognitive function and MRI measures in community-based samples of middle-aged to older adults. METHODS: We included dementia-free participants from nine diverse community-based cohorts with whole-genome sequencing in the Trans-Omics for Precision Medicine (TOPMed) program...
March 16, 2023: Neurology
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JOURNAL ARTICLE
Jukka Peltola, Albert J Colon, José Pimentel, Volker A Coenen, Antonio Gil-Nagel, Antonio Gonçalves Ferreira, Kai Lehtimäki, Philippe Ryvlin, Rod S Taylor, Linda Ackermans, Jacqueline Ardesch, Carla Bentes, Magdalena Bosak, Jorge G Burneo, Clara Chamadoira, Christian E Elger, Loránd Erőss, Dániel Fabo, Howard Faulkner, Jacek Gawlowicz, Alireza Gharabaghi, Maurizio Iacoangeli, Jozsef Janszky, Soila Järvenpää, Elisabeth Kaufmann, Kuan H Kho, Eva Kumlien, Helmut Laufs, Christian Lettieri, Paulo Linhares, Soheyl Noachtar, Andrew Parrent, Ekaterina Pataraia, Nikunj K Patel, Ana Rita Peralta, Attila Rácz, Alexandre Rainha Campos, Ricardo Rego, Riccardo A Ricciuti, Sabine Rona, Rob P W Rouhl, Andreas Schulze-Bonhage, Rick Schuurman, Mathieu Sprengers, Albert Sufianov, Yasin Temel, Tom Theys, Wim Van Paesschen, Dirk Van Roost, Rui Vaz, Kristl Vonck, Louis Wagner, Jack Zwemmer, Abdallah Abouihia, Thomas C Brionne, Frans Gielen, Paul A J M Boon
and ObjectivesThe efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in drug resistant epilepsy (DRE) patients was demonstrated in the double-blind Stimulation of theAnterior Nucleus of the Thalamus for Epilepsy (SANTE) randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice.MethodsMORE is an observational registry collecting prospective and retrospective clinical data...
March 16, 2023: Neurology
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