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Neurology

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https://read.qxmd.com/read/31300547/comparative-effectiveness-of-teriflunomide-vs-dimethyl-fumarate-in-multiple-sclerosis
#1
David-Axel Laplaud, Romain Casey, Laetitia Barbin, Marc Debouverie, Jérôme De Sèze, David Brassat, Sandrine Wiertlewski, Bruno Brochet, Jean Pelletier, Patrick Vermersch, Gilles Edan, Christine Lebrun-Frenay, Pierre Clavelou, Eric Thouvenot, Jean-Philippe Camdessanché, Ayman Tourbah, Bruno Stankoff, Abdullatif Al Khedr, Philippe Cabre, Catherine Lubetzki, Caroline Papeix, Eric Berger, Olivier Heinzlef, Thomas Debroucker, Thibault Moreau, Olivier Gout, Bertrand Bourre, Abir Wahab, Pierre Labauge, Laurent Magy, Gilles Defer, Anne-Marie Guennoc, Nicolas Maubeuge, Céline Labeyrie, Ivania Patry, Chantal Nifle, Olivier Casez, Laure Michel, Fabien Rollot, Emmanuelle Leray, Sandra Vukusic, Yohann Foucher
OBJECTIVE: In this study, we compared the effectiveness of teriflunomide (TRF) and dimethyl fumarate (DMF) on both clinical and MRI outcomes in patients followed prospectively in the Observatoire Français de la Sclérose en Plaques. METHODS: A total of 1,770 patients with relapsing-remitting multiple sclerosis (RRMS) (713 on TRF and 1,057 on DMF) with an available baseline brain MRI were included in intention to treat. The 1- and 2-year postinitiation outcomes were relapses, increase of T2 lesions, increase in Expanded Disability Status Scale score, and reason for treatment discontinuation...
July 12, 2019: Neurology
https://read.qxmd.com/read/31300546/peripheral-nervous-system-alterations-in-infant-and-adult-neurofibromatosis-type-2
#2
Tim Godel, Philipp Bäumer, Said Farschtschi, Isabel Gugel, Moritz Kronlage, Barbara Hofstadler, Sabine Heiland, Mathias Gelderblom, Martin Bendszus, Victor-Felix Mautner
OBJECTIVE: To examine the involvement of dorsal root ganglia and peripheral nerves in children with neurofibromatosis type 2 compared to healthy controls and symptomatic adults by in vivo high-resolution magnetic resonance neurography. METHODS: In this prospective multicenter study, the lumbosacral dorsal root ganglia and sciatic, tibial, and peroneal nerves were examined in 9 polyneuropathy-negative children diagnosed with neurofibromatosis type 2 by a standardized magnetic resonance neurography protocol at 3T...
July 12, 2019: Neurology
https://read.qxmd.com/read/31300545/harnessing-real-world-data-to-inform-treatment-decisions-in-multiple-sclerosis
#3
EDITORIAL
Carrie M Hersh, Ruth Ann Marrie
No abstract text is available yet for this article.
July 12, 2019: Neurology
https://read.qxmd.com/read/31296654/disability-after-minor-stroke-and-tia-a-secondary-analysis-of-the-socrates-trial
#4
Brett Cucchiara, Donna Kurowski George, Scott E Kasner, Mikael Knutsson, Hans Denison, Per Ladenvall, Pierre Amarenco, S Claiborne Johnston
OBJECTIVE: To examine factors associated with disability following TIA and minor stroke, including poststroke complications such as stroke recurrence, major bleeding, and other adverse medical events. METHODS: The SOCRATES trial randomized patients with TIA/minor stroke (NIH Stroke Scale [NIHSS] score ≤5) within 24 hours of onset. We performed a post hoc analysis of factors associated with disability (modified Rankin Scale [mRS] score >1). TIA and minor stroke were analyzed separately...
July 11, 2019: Neurology
https://read.qxmd.com/read/31296653/microstructural-white-matter-changes-preceding-white-matter-hyperintensities-in-migraine
#5
Enrico B Arkink, Inge H Palm-Meinders, Hille Koppen, Julien Milles, Baldur van Lew, Lenore J Launer, Paul A M Hofman, Gisela M Terwindt, Mark A van Buchem, Michel D Ferrari, Mark C Kruit
OBJECTIVE: We used magnetization transfer imaging to assess white matter tissue integrity in migraine, to explore whether white matter microstructure was more diffusely affected beyond visible white matter hyperintensities (WMHs), and to explore whether focal invisible microstructural changes precede visible focal WMHs in migraineurs. METHODS: We included 137 migraineurs (79 with aura, 58 without aura) and 74 controls from the Cerebral Abnormalities in Migraine, an Epidemiological Risk Analysis (CAMERA) study, a longitudinal population-based study on structural brain lesions in migraine patients, who were scanned at baseline and at a 9-year follow-up...
July 11, 2019: Neurology
https://read.qxmd.com/read/31292226/suppression-of-the-photoparoxysmal-response-in-photosensitive-epilepsy-with-cenobamate-ykp3089
#6
Dorothee G A Kasteleijn-Nolst Trenite, Bree D DiVentura, John R Pollard, Gregory L Krauss, Sarah Mizne, Jacqueline A French
OBJECTIVE: To evaluate the effect of cenobamate in patients with photoparoxysmal-EEG response (PPR) to intermittent photic stimulation (IPS) as proof of principle of efficacy in patients with epilepsy. METHODS: In this multicenter, single-blind study, adults with photosensitive epilepsy, with/without concomitant antiepileptic drug therapy, underwent IPS under 3 eye conditions after a single dose of placebo (day -1, day 2) or cenobamate (day 1; 100, 250, or 400 mg)...
July 10, 2019: Neurology
https://read.qxmd.com/read/31292225/the-risk-of-new-onset-epilepsy-and-refractory-epilepsy-in-older-adult-stroke-survivors
#7
Jorge G Burneo, Tresah C Antaya, Britney N Allen, Andrea Belisle, Salimah Z Shariff, Gustavo Saposnik
OBJECTIVE: Our study objectives were to identify factors associated with new-onset epilepsy and refractory epilepsy among older adult stroke survivors and to evaluate the receipt of diagnostic care and mortality for participants who developed epilepsy. METHODS: We conducted a population-based, retrospective cohort study using linked, administrative health care databases. The Ontario Stroke Registry was used to identify patients 67 years and older who were hospitalized for a stroke at a designated stroke center in Ontario, Canada, between April 1, 2003, and March 31, 2009, and were previously free of epilepsy...
July 10, 2019: Neurology
https://read.qxmd.com/read/31292224/quantity-and-quality-of-mental-activities-and-the-risk-of-incident-mild-cognitive-impairment
#8
Janina Krell-Roesch, Jeremy A Syrjanen, Maria Vassilaki, Mary M Machulda, Michelle M Mielke, David S Knopman, Walter K Kremers, Ronald C Petersen, Yonas E Geda
OBJECTIVE: To investigate whether timing, number, and frequency of mentally stimulating activities in midlife and late life are associated with the risk of incident mild cognitive impairment (MCI). METHODS: We conducted a prospective cohort study in the setting of the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota, including 2,000 individuals aged ≥70 years who were cognitively unimpaired at baseline and were followed for a median of 5...
July 10, 2019: Neurology
https://read.qxmd.com/read/31292223/quantitative-mr-neurography-biomarkers-in-5q-linked-spinal-muscular-atrophy
#9
Jennifer Kollmer, Tim Hilgenfeld, Andreas Ziegler, Afshin Saffari, Georges Sam, John M Hayes, Adriana Pietsch, Marie Jost, Sabine Heiland, Martin Bendszus, Wolfgang Wick, Markus Weiler
OBJECTIVE: To characterize and quantify peripheral nerve lesions and muscle degeneration in clinically, genetically, and electrophysiologically well-classified, nonpediatric patients with 5q-linked spinal muscular atrophy (SMA) by high-resolution magnetic resonance neurography (MRN). METHODS: Thirty-one adult patients with genetically confirmed 5q-linked SMA types II, IIIa, and IIIb and 31 age- and sex-matched healthy volunteers were prospectively investigated. All patients received neurologic, physiotherapeutic, and electrophysiologic assessments...
July 10, 2019: Neurology
https://read.qxmd.com/read/31292222/frequency-number-and-timing-of-mental-activity-and-risk-of-mild-cognitive-impairment
#10
EDITORIAL
Irina A Skylar-Scott, Robert S Wilson, Rebecca E Amariglio
No abstract text is available yet for this article.
July 10, 2019: Neurology
https://read.qxmd.com/read/31289148/determining-clinically-meaningful-decline-in-preclinical-alzheimer-disease
#11
Philip S Insel, Michael Weiner, R Scott Mackin, Elizabeth Mormino, Yen Ying Lim, Erik Stomrud, Sebastian Palmqvist, Colin L Masters, Paul T Maruff, Oskar Hansson, Niklas Mattsson
OBJECTIVE: To determine the time required for a preclinical Alzheimer disease population to decline in a meaningful way, use estimates of decline to update previous clinical trial design assumptions, and identify factors that modify β-amyloid (Aβ)-related decline. METHODS: In 1,120 cognitively unimpaired individuals from 3 international cohorts, we estimated the relationship between Aβ status and longitudinal changes across multiple cognitive domains and assessed interactions between Aβ and baseline factors...
July 9, 2019: Neurology
https://read.qxmd.com/read/31289147/demyelinating-lesions-and-progressive-ms-location-location-location
#12
EDITORIAL
E Ann Yeh, Robert J Fox
No abstract text is available yet for this article.
July 9, 2019: Neurology
https://read.qxmd.com/read/31289146/minor-hallucinations-in-parkinson-disease-a-subtle-symptom-with-major-clinical-implications
#13
REVIEW
Abhishek Lenka, Javier Pagonabarraga, Pramod Kumar Pal, Helena Bejr-Kasem, Jaime Kulisvesky
OBJECTIVE: Psychosis is one of the most debilitating complications of Parkinson disease (PD). Although research on PD psychosis has been focused on the study of well-structured visual hallucinations (VH), currently accepted National Institute of Neurological Disorders and Stroke-National Institute of Mental Health diagnostic criteria emphasize minor hallucinations (MH) as the most common psychotic phenomena in PD. The objective of this review is to comprehensively describe the clinical and research advances on the understanding of MH and to provide future directions for obtaining further insights into their potential major implications for PD management and prognosis...
July 9, 2019: Neurology
https://read.qxmd.com/read/31289145/the-search-for-meaning-in-preclinical-alzheimer-disease-clinical-trials
#14
EDITORIAL
S Duke Han, Hitoshi Shinotoh
No abstract text is available yet for this article.
July 9, 2019: Neurology
https://read.qxmd.com/read/31289144/saposin-b-deficiency-as-a-cause-of-adult-onset-metachromatic-leukodystrophy
#15
Silvia Fenu, Barbara Castellotti, Laura Farina, Tiziana Cavallaro, Daniela Di Bella, Chiara Benzoni, Cinzia Gellera, Davide Pareyson, Franco Taroni, Ettore Salsano
No abstract text is available yet for this article.
July 9, 2019: Neurology
https://read.qxmd.com/read/31289143/effect-of-polygenic-load-on-striatal-dopaminergic-deterioration-in-parkinson-disease
#16
Myung Jun Lee, Kyoungjune Pak, Jong Hun Kim, Yun Joong Kim, Jeehee Yoon, Jinwoo Lee, Chul Hyoung Lyoo, Hyung Jun Park, Jae-Hyeok Lee, Na-Yeon Jung
OBJECTIVE: To investigate the effect of polygenic load on the progression of striatal dopaminergic dysfunction in patients with Parkinson disease (PD). METHODS: Using data from 335 patients with PD in the Parkinson's Progression Markers Initiative (PPMI) database, we investigated the longitudinal association of PD-associated polygenic load with changes in striatal dopaminergic activity as measured by 123 I-N-3-fluoropropyl-2-β-carboxymethoxy-3β-(4-iodophenyl) nortropane (123 I-FP-CIT) SPECT over 4 years...
July 9, 2019: Neurology
https://read.qxmd.com/read/31289142/unilateral-motor-progression-in-ms-association-with-a-critical-corticospinal-tract-lesion
#17
Elia Sechi, B Mark Keegan, Timothy J Kaufmann, Orhun H Kantarci, Brian G Weinshenker, Eoin P Flanagan
OBJECTIVE: Progressive motor impairment anatomically attributable to a single critical demyelinating lesion on eloquent corticospinal tract locations occurs in progressive solitary sclerosis and in some patients with multiple sclerosis (MS) with highly restricted CNS lesion burden (2-5 lesions). We determined whether a similar critical lesion is found in patients with MS with unilateral motor progression and unlimited lesion burden. METHODS: In this observational study, we retrospectively identified Mayo Clinic patients (January 1, 1996-December 31, 2017) with an MS diagnosis (2017 McDonald criteria), ≥1 year of exclusively unilateral motor progression, and >5 demyelinating lesions on MRI...
July 9, 2019: Neurology
https://read.qxmd.com/read/31285398/cumulative-gadodiamide-administration-leads-to-brain-gadolinium-deposition-in-early-ms
#18
Robert Zivadinov, Niels Bergsland, Jesper Hagemeier, Deepa P Ramasamy, Michael G Dwyer, Ferdinand Schweser, Channa Kolb, Bianca Weinstock-Guttman, David Hojnacki
OBJECTIVE: Frequent administration of gadolinium-based contrast agents in multiple sclerosis (MS) may increase signal intensity (SI) unenhanced T1-weighted imaging MRI throughout the brain. We evaluated the association between lifetime cumulative doses of gadodiamide administration and increased SI within the dentate nucleus (DN), globus pallidus (GP), and thalamus in patients with early MS. METHODS: A total of 203 patients with MS (107 with baseline and follow-up MRI assessments) and 262 age- and sex-matched controls were included in this retrospective, longitudinal, 3T MRI-reader-blinded study...
July 8, 2019: Neurology
https://read.qxmd.com/read/31285397/use-of-gadolinium-for-mri-diagnostic-or-surveillance-studies-in-patients-with-ms
#19
EDITORIAL
Lukas Haider, Robert T Naismith, Alex Rovira
No abstract text is available yet for this article.
July 8, 2019: Neurology
https://read.qxmd.com/read/31278117/muscle-targeted-nutritional-support-for-rehabilitation-in-patients-with-parkinsonian-syndrome
#20
Michela Barichella, Emanuele Cereda, Giovanna Pinelli, Laura Iorio, Diana Caroli, Irene Masiero, Valentina Ferri, Erica Cassani, Carlotta Bolliri, Serena Caronni, Marcello Maggio, Paola Ortelli, Davide Ferrazzoli, Antonios Maras, Giulio Riboldazzi, Giuseppe Frazzitta, Gianni Pezzoli
OBJECTIVE: We evaluated the efficacy of muscle-targeted nutritional support on the functional outcomes of multidisciplinary intensive rehabilitation treatment (MIRT) in patients with Parkinson disease (PD) or parkinsonism. METHODS: We conducted a pragmatic, bicentric, randomized (1:1), assessor-blind controlled trial (Protein, Leucine and Vitamin D Enhancing Rehabilitation [PRO-LEADER]; April 2017 to January 2018) in cognitively intact patients with PD or parkinsonism and undergoing a 30-day MIRT...
July 5, 2019: Neurology
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