Stefanie Binzer, Kyla A McKay, Philip Brenner, Jan Hillert, Ali Manouchehrinia
OBJECTIVE: Depression is common in multiple sclerosis (MS), but its impact on disability worsening has not yet been determined. We explored the risk of disability worsening associated with depression in a nationwide longitudinal cohort. METHODS: This retrospective cohort study used linked data from 3 Swedish nationwide registries: the MS Register, National Patient Register, and Prescribed Drug Register. Two incident cohorts were developed: cohort 1 included all registered cases of MS in the MS Registry (2001-2014) with depression defined as ≥1 ICD-10 code for depression; and cohort 2 comprised all cases of MS in the MS Registry (2005-2014) with depression defined as ≥1 prescription filled for an antidepressant...
November 8, 2019: Neurology
Sandra Weintraub, Merilee Teylan, Benjamin Rader, Kwun C G Chan, Mark Bollenbeck, Walter A Kukull, Christina Coventry, Emily Rogalski, Eileen Bigio, M-Marsel Mesulam
OBJECTIVE: To compare the proportion of APOE ε4 genotype carriers in aphasic vs amnestic variants of Alzheimer disease (AD). METHOD: The proportion of APOE ε4 carriers was compared among the following 3 groups: (1) 42 patients with primary progressive aphasia (PPA) and AD pathology (PPA/AD) enrolled in the Northwestern Alzheimer Disease Center Clinical Core; (2) 1,418 patients with autopsy-confirmed AD and amnestic dementia of the Alzheimer type (DAT/AD); and (3) 2,608 cognitively normal controls (NC)...
November 8, 2019: Neurology
Allison S Young, Brent McMonagle, David V Pohl, John Magnussen, Miriam S Welgampola
No abstract text is available yet for this article.
November 7, 2019: Neurology
Andrea M Harriott, Fahri Karakaya, Cenk Ayata
OBJECTIVE: Headache associated with ischemic stroke is poorly understood. To gain further insight, we systematically reviewed studies examining the prevalence and characteristics of new-onset poststroke headache. METHODS: Medline and PubMed databases were queried. A total of 1,812 articles were identified. Of these, 50 were included in this systematic review. Twenty were included in a meta-analysis and meta-regression. RESULTS: Headache occurred in 6%-44% of the ischemic stroke population...
November 6, 2019: Neurology
Jordan W Squair, Amanda H X Lee, Zoe K Sarafis, Geoff Coombs, Otto Barak, Jacquelyn J Cragg, Tanja Mijacika, Renata Pecotic, Andrei V Krassioukov, Zoran Dogas, Zeljko Dujic, Aaron A Phillips
OBJECTIVE: To determine the population-level odds of individuals with spinal cord injury (SCI) experiencing fatigue and sleep apnea, to elucidate relationships with level and severity of injury, and to examine associations with abnormal cerebrovascular responsiveness. METHODS: We used population-level data, meta-analyses, and primary physiologic assessments to provide a large-scale integrated assessment of sleep-related complications after SCI. Population-level and meta-analyses included more than 60,000 able-bodied individuals and more than 1,800 individuals with SCI...
November 6, 2019: Neurology
Bang Zheng, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Mi Zhou, Ling Yang, Yiping Chen, Xiaojun Li, Ju Zou, Feng Ning, Junshi Chen, Zhengming Chen, Liming Li
OBJECTIVE: To examine the associations of individual insomnia symptoms with risks of incident cardio-cerebral vascular diseases (CVD) and possible moderating factors among Chinese adults. METHODS: The China Kadoorie Biobank is a prospective cohort study that recruited participants from 10 areas across China. Data from 487,200 adults 30 to 79 years of age who were free of stroke, coronary heart disease, and cancer at baseline were analyzed. Three insomnia symptoms were assessed with self-reported difficulties in initiating or maintaining sleep, early morning awakening, and daytime dysfunction for at least 3 d/wk at baseline...
November 6, 2019: Neurology
Richard B Lipton, Kristina M Fanning, Dawn C Buse, Vincent T Martin, Lee B Hohaia, Aubrey Manack Adams, Michael L Reed, Peter J Goadsby
OBJECTIVE: To test the hypothesis that statistically defined subgroups of migraine (based on constellations of comorbidities and concomitant conditions; henceforth comorbidities), previously identified using Chronic Migraine Epidemiology and Outcomes (CaMEO) Study data, differ in prognosis, as measured by rates of progression from episodic migraine (EM) to chronic migraine (CM). METHODS: The onset of CM was assessed up to 4 times over 12 months in individuals with EM and ≥1 comorbidity at baseline, based on constellations of comorbidities (comorbidity classes)...
November 5, 2019: Neurology
Wing H Wong, Larry Junck, Todd E Druley, David H Gutmann
No abstract text is available yet for this article.
November 5, 2019: Neurology
Nina F Schor, Allison Brashear
No abstract text is available yet for this article.
November 5, 2019: Neurology
Tasneem F Hasan, Marion T Turnbull, Kenneth A Vatz, Maisha T Robinson, Elizabeth A Mauricio, William D Freeman
Neurology faces an increasing shortage of neurologists in the United States due to a growing demand for neurologic services. A 7% increase in the supply of neurologists is predicted from 2012 to 2025, whereas the demand will rise by 16%. An increase in the neurology workforce is critical to meet the demands, and a significant gender gap remains within the workforce that must be addressed to further ease the discrepancy between supply and demand. Individual, institutional, and societal factors contribute to this gender discrepancy and potentially result in the burnout or soft attrition of women from neurology...
November 5, 2019: Neurology
Dalia L Rotstein, Ruth Ann Marrie, Colleen Maxwell, Sima Gandhi, Susan E Schultz, Kinwah Fung, Karen Tu
OBJECTIVE: To determine risk factors for multiple sclerosis (MS) in immigrants and to compare MS risk in immigrants and long-term residents in Ontario, Canada. METHODS: We applied a validated algorithm to linked, population-based immigration and health claims data to identify incident cases of MS in immigrants and long-term residents between 1994 and 2016. We conducted 2 multivariable Cox proportional hazards regression analyses: 1 analysis limited to the immigrant cohort assessing potential risk factors for developing MS, and 1 analysis comparing MS risk between immigrants and matched long-term residents (1:3 match)...
November 5, 2019: Neurology
Christian Boehme, Thomas Toell, Lukas Mayer, Lena Domig, Raimund Pechlaner, Karin Willeit, Lena Tschiderer, Lisa Seekircher, Peter Willeit, Andrea Griesmacher, Michael Knoflach, Johann Willeit, Stefan Kiechl
OBJECTIVE: To analyze the frequency of inadequately treated risk factors in a large representative cohort of patients with acute ischemic stroke or TIA and to estimate the proportion of events potentially avertable by guideline-compliant preventive therapy compared to the status quo. METHODS: A total of 1,730 patients from the Poststroke Disease Management STROKE-CARD trial (NCT02156778) were recruited between 2014 and 2017. We focused on 8 risk conditions amenable to drug therapy and 3 lifestyle risk behaviors and assessed pre-event risk factor control in retrospect...
October 31, 2019: Neurology
Jocelyn Zwicker, Danial Qureshi, Robert Talarico, Pierre Bourque, Mary Scott, Nicolas Chin-Yee, Peter Tanuseputro
OBJECTIVE: To describe health care service utilization and cost for decedents with and without amyotrophic lateral sclerosis (ALS) in the last year of life. METHODS: Using linked health administrative data, we conducted a retrospective, population-based cohort study of Ontario, Canada, decedents from 2013 to 2015. We examined demographic data, rate of utilization, and cost of health care services in the last year of life. RESULTS: We identified 283,096 decedents in Ontario, of whom 1,212 (0...
October 31, 2019: Neurology
Laurel A Beckett, Lars F Berglund
No abstract text is available yet for this article.
October 31, 2019: Neurology
James A Russell, E Ray Dorsey
No abstract text is available yet for this article.
October 31, 2019: Neurology
Kirsty Lu, Jennifer M Nicholas, Jessica D Collins, Sarah-Naomi James, Thomas D Parker, Christopher A Lane, Ashvini Keshavan, Sarah E Keuss, Sarah M Buchanan, Heidi Murray-Smith, David M Cash, Carole H Sudre, Ian B Malone, William Coath, Andrew Wong, Susie M D Henley, Sebastian J Crutch, Nick C Fox, Marcus Richards, Jonathan M Schott
OBJECTIVE: To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations between cognition and dementia biomarkers in Insight 46, a substudy of the Medical Research Council National Survey of Health and Development. METHODS: A total of 502 individuals born in the same week in 1946 underwent cognitive assessment at age 69-71 years, including an adapted version of the PACC and a test of nonverbal reasoning...
October 30, 2019: Neurology
Lidia M V R Moura, Brandon Magliocco, John P Ney, Eric M Cheng, Gregory J Esper, Daniel B Hoch
OBJECTIVE: To see if systematic collection of patient-reported epilepsy quality measures can identify opportunities to improve care, and to examine the associations between these measures and physical and mental health. METHODS: We developed a patient-reported questionnaire for medication adherence, seizure frequency, medication side effects, and driving that included the Patient-Reported Outcome Measurement Information System-10 (PROMIS-10) (physical and mental health)...
October 30, 2019: Neurology
Sarah K Diehl, Antje S Mefferd, Ya-Chen Lin, Jessie Sellers, Katherine E McDonell, Michael de Riesthal, Daniel O Claassen
OBJECTIVE: Dysarthric speech of persons with Huntington disease (HD) is typically described as hyperkinetic; however, studies suggest that dysarthria can vary and resemble patterns in other neurologic conditions. To test the hypothesis that distinct motor speech subgroups can be identified within a larger cohort of patients with HD, we performed a cluster analysis on speech perceptual characteristics of patient audio recordings. METHODS: Audio recordings of 48 patients with mild to moderate dysarthria due to HD were presented to 6 trained raters...
October 29, 2019: Neurology
Perrine Guillaume-Jugnot, Sarah Guégan, Sarah Léonard-Louis, Stéphane Barete, Olivier Benveniste, Yves Allenbach
No abstract text is available yet for this article.
October 29, 2019: Neurology
George Ntaios, Georgios Georgiopoulos, Kalliopi Perlepe, Gaia Sirimarco, Davide Strambo, Ashraf Eskandari, Stefania Nannoni, Anastasia Vemmou, Eleni Koroboki, Efstathios Manios, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Jaume Roquer, Valentina Arnao, Valeria Caso, Maurizio Paciaroni, Exuperio Diez-Tejedor, Blanca Fuentes, Jorge Rodríguez Pardo, Sara Sánchez-Velasco, Antonio Arauz, Sebastian F Ameriso, Lucía Pertierra, Maia Gómez-Schneider, Maximiliano A Hawkes, Miguel A Barboza, Beatriz Chavarria Cano, Ana Maria Iglesias Mohedano, Andrés García Pastor, Antonio Gil-Núñez, Jukka Putaala, Turgut Tatlisumak, Efstathia Karagkiozi, Vasileios Papavasileiou, Konstantinos Makaritsis, Fabio Bandini, Konstantinos Vemmos, Patrik Michel
OBJECTIVE: A tool to stratify the risk of stroke recurrence in patients with embolic stroke of undetermined source (ESUS) could be useful in research and clinical practice. We aimed to determine whether a score can be developed and externally validated for the identification of patients with ESUS at high risk for stroke recurrence. METHODS: We pooled the data of all consecutive patients with ESUS from 11 prospective stroke registries. We performed multivariable Cox regression analysis to identify predictors of stroke recurrence...
October 29, 2019: Neurology
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