journal
https://read.qxmd.com/read/38630966/glutamate-signaling-in-patients-with-parkinson-disease-with-rem-sleep-behavior-disorder
#1
JOURNAL ARTICLE
Christopher E J Doppler, Aline Seger, Ezequiel Farrher, Cláudia Régio Brambilla, Lukas Hensel, Christian P Filss, Martin Hellmich, Ana Gogishvili, N Jon Shah, Christoph W Lerche, Bernd Neumaier, Karl-Josef Langen, Gereon R Fink, Michael Sommerauer
BACKGROUND AND OBJECTIVES: Clinical heterogeneity of patients with Parkinson disease (PD) is well recognized. PD with REM sleep behavior disorder (RBD) is a more malignant phenotype with faster motor progression and higher nonmotor symptom burden. However, the neural mechanisms underlying this clinical divergence concerning imbalances in neurotransmitter systems remain elusive. METHODS: Combining magnetic resonance (MR) spectroscopy and [11 C]ABP688 PET on a PET/MR hybrid system, we simultaneously investigated two different mechanisms of glutamate signaling in patients with PD...
May 14, 2024: Neurology
https://read.qxmd.com/read/38630962/one-year-longitudinal-assessment-of-patients-with-cmt1a-using-quantitative-mri
#2
JOURNAL ARTICLE
Etienne Fortanier, Marc Adrien Hostin, Constance Michel, Emilien Delmont, Marc-Emmanuel Bellemare, Maxime Guye, David Bendahan, Shahram Attarian
BACKGROUND AND OBJECTIVES: Intramuscular fat fraction (FF) assessed using quantitative MRI (qMRI) has emerged as one of the few responsive outcome measures in CMT1A suitable for future clinical trials. This study aimed to identify the relevance of multiple qMRI biomarkers for tracking longitudinal changes in CMT1A and to assess correlations between MRI metrics and clinical parameters. METHODS: qMRI was performed in CMT1A patients at 2 time points, a year apart, and various metrics were extracted from 3-dimensional volumes of interest at thigh and leg levels...
May 14, 2024: Neurology
https://read.qxmd.com/read/38630959/trajectories-of-occupational-cognitive-demands-and-risk-of-mild-cognitive-impairment-and-dementia-in-later-life-the-hunt4-70-study
#3
JOURNAL ARTICLE
Trine H Edwin, Asta K Håberg, Ekaterina Zotcheva, Bernt Bratsberg, Astanand Jugessur, Bo Engdahl, Catherine Bowen, Geir Selbæk, Hans-Peter Kohler, Jennifer R Harris, Sarah E Tom, Steinar Krokstad, Teferi Mekonnen, Yaakov Stern, Vegard F Skirbekk, Bjørn H Strand
BACKGROUND AND OBJECTIVES: The cognitive reserve hypothesis posits that cognitively stimulating work delays the onset of mild cognitive impairment (MCI) and dementia. However, the effect of occupational cognitive demands across midlife on the risk of these conditions is unclear. METHODS: Using a cohort study design, we evaluated the association between registry-based trajectories of occupational cognitive demands from ages 30-65 years and clinically diagnosed MCI and dementia in participants in the HUNT4 70+ Study (2017-19)...
May 14, 2024: Neurology
https://read.qxmd.com/read/38626375/association-of-localizing-18-f-fdg-pet-hypometabolism-and-outcome-following-epilepsy-surgery-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Merran R Courtney, Ana Antonic-Baker, Zhibin Chen, Benjamin Sinclair, John-Paul Nicolo, Andrew Neal, Cassandra Marotta, Jacob Bunyamin, Meng Law, Patrick Kwan, Terence J O'Brien, Lucy Vivash
BACKGROUND AND OBJECTIVES: Although commonly used in the evaluation of patients for epilepsy surgery, the association between the detection of localizing 18 fluorine fluorodeoxyglucose PET (18 F-FDG-PET) hypometabolism and epilepsy surgery outcome is uncertain. We conducted a systematic review and meta-analysis to determine whether localizing 18 F-FDG-PET hypometabolism is associated with favorable outcome after epilepsy surgery. METHODS: A systematic literature search was undertaken...
May 14, 2024: Neurology
https://read.qxmd.com/read/38626367/bridging-the-gap-in-small-vessel-disease-research-perivascular-spaces-in-the-clinical-space
#5
EDITORIAL
Amy Brodtmann, Saima Hilal
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38626363/glucose-control-and-risk-of-symptomatic-intracerebral-hemorrhage-following-thrombolysis-for-acute-ischemic-stroke-a-shine-trial-analysis
#6
JOURNAL ARTICLE
Andrew M Southerland, Stephan A Mayer, Nicole A Chiota-McCollum, Ashley C Bolte, Qi Pauls, L Creed Pettigrew, Thomas P Bleck, Mark Conaway, Karen C Johnston
BACKGROUND AND OBJECTIVES: Baseline hyperglycemia is associated with worse outcomes in acute ischemic stroke (AIS), including higher risk of symptomatic intracerebral hemorrhage (sICH) following treatment with thrombolysis. Prospective data are lacking to inform management of post-thrombolysis hyperglycemia. In a prespecified analysis from the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial of hyperglycemic stroke management, we hypothesized that post-thrombolysis hyperglycemia is associated with a higher risk of sICH...
May 14, 2024: Neurology
https://read.qxmd.com/read/38621220/reader-response-what-is-the-ideal-brain-criterion-of-death-nonclinical-considerations-the-udda-revision-series
#7
JOURNAL ARTICLE
Calixto Machado
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38621187/author-response-what-is-the-ideal-brain-criterion-of-death-nonclinical-considerations-the-udda-revision-series
#8
JOURNAL ARTICLE
Michael A Rubin
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38621186/editors-note-what-is-the-ideal-brain-criterion-of-death-nonclinical-considerations-the-udda-revision-series
#9
JOURNAL ARTICLE
Ariane Lewis, Steven Galetta
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38608230/open-peer-review-reports-a-pilot-project-in-neurology-%C3%A2
#10
EDITORIAL
Patricia K Baskin, Frederik Barkhof, Rebecca Burch, Brian C Callaghan, Olga Ciccarelli, Peter Hedera, Linda A Hershey, Barbara C Jobst, Kathleen M Pieper, Sharon L Quimby, Andrea Rahkola, Andrea L Schneider, Bradford B Worrall, Courtney J Wusthoff, José G Merino
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38608210/disparities-in-teleneurology-use-in-medicaid-beneficiaries-with-epilepsy-by-practice-setting-promoting-health-equity-in-academic-centers
#11
JOURNAL ARTICLE
Evelyn Gotlieb, Parul Agarwal, Leah J Blank, Churl-Su Kwon, Maria Muxfeldt, James J Young, Nathalie Jette
BACKGROUND AND OBJECTIVES: Medicaid beneficiaries in many American academic medical centers can receive care in a separate facility than those not covered by Medicaid. We aimed to identify possible disparities in care by evaluating the association between facility type (integrated faculty practice or Medicaid-only outpatient clinic ) and telehealth utilization in people with epilepsy. METHODS: We performed retrospective analyses using structured data from the Mount Sinai Health System electronic medical record data from January 2003 to August 2021...
May 14, 2024: Neurology
https://read.qxmd.com/read/38598746/effects-of-achieving-rapid-intensive-and-sustained-blood-pressure-reduction-in-intracerebral-hemorrhage-expansion-and-functional-outcome
#12
MULTICENTER STUDY
David Rodriguez-Luna, Olalla Pancorbo, Laura Llull, Yolanda Silva, Luis Prats-Sanchez, Marián Muchada, Salvatore Rudilosso, Mikel Terceño, Anna Ramos-Pachón, Mar Hernandez Guillamon, Pilar Coscojuela, Jordi Blasco, Santiago Perez-Hoyos, Angel Chamorro, Carlos A Molina
BACKGROUND AND OBJECTIVES: The time taken to achieve blood pressure (BP) control could be pivotal in the benefits of reducing BP in acute intracerebral hemorrhage (ICH). We aimed to assess the relationship between the rapid achievement and sustained maintenance of an intensive systolic BP (SBP) target with radiologic, clinical, and functional outcomes. METHODS: Rapid, Intensive, and Sustained BP lowering in Acute ICH (RAINS) was a multicenter, prospective, observational cohort study of adult patients with ICH <6 hours and SBP ≥150 mm Hg at 4 Comprehensive Stroke Centers during a 4...
May 14, 2024: Neurology
https://read.qxmd.com/read/38598742/burden-of-stroke-attributable-to-nonoptimal-temperature-in-204-countries-and-territories-a-population-based-study-1990-2019
#13
JOURNAL ARTICLE
Chunrun Qu, Yu Chen, Chen Liu, Zhiwen Hu, Jingwei Zhang, Luzhe Yan, Hao Zhang, Yifan Liu, Wanyao Liu, Quan Cheng, Peng Luo, Zhixiong Liu
BACKGROUND AND OBJECTIVES: Stroke attributable to nonoptimal temperature needs more attention with dramatic climate change. The aim of this study was to estimate the global burden and distribution characteristics of the burden. METHODS: In this ecological study, we collected data from the Climate Research Unit Gridded Time Series, the World Bank databases, and the Global Burden of Diseases study to estimate the distribution of burden. We used the joinpoint model, decomposition analysis, age-period-cohort model, panel data analysis, and health inequality analysis to assess the different types of stroke burden attributable to different climatic conditions...
May 14, 2024: Neurology
https://read.qxmd.com/read/38593399/video-analyses-of-sudden-unexplained-deaths-in-toddlers
#14
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38593398/roving-eye-and-head-in-a-patient-with-genetic-creutzfeldt-jakob-disease
#15
JOURNAL ARTICLE
Katsuya Nishida
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38593397/immunosuppressive-therapy-reversing-obstructive-hydrocephalus-in-clippers
#16
JOURNAL ARTICLE
Yi Yang, Shuhua Li, Yang Yang, Ting Zeng, Jinmei Li, Yufeng Tang
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38593396/teaching-video-neuroimage-bilateral-hemifacial-spasm-and-left-glossopharyngeal-neuralgia-caused-by-bilateral-vertebral-artery-displacement
#17
JOURNAL ARTICLE
Zongli Han, Yanli Du, Siyang Zheng, Guangyuan Wu
No abstract text is available yet for this article.
May 14, 2024: Neurology
https://read.qxmd.com/read/38593395/clinical-reasoning-a-24-year-old-man-with-gait-impairment-hearing-loss-and-recurrent-fever
#18
JOURNAL ARTICLE
Adriel Rêgo Barbosa, Marianna Pinheiro Moraes de Moraes, Thiago Yoshinaga Tonholo Silva, José Luiz Pedroso, Orlando Graziani Povoas Barsottini
We present a case study of a 24-year-old man who reported mild balance and walking difficulties for 2 years. He had a history of recurrent fever, skin lesions, headache, and elbow pain, but most of these events resolved spontaneously. There was no significant family history. On examination, we observed frontal bossing, sensorineural hearing loss, and gait ataxia. This case underscores the significance of identifying clinical indicators in patients with neurologic symptoms, particularly recurrent fever, to establish a precise and thorough differential diagnosis...
May 14, 2024: Neurology
https://read.qxmd.com/read/38593394/proportion-of-community-dwelling-individuals-older-than-70-years-eligible-for-lecanemab-initiation-the-gothenburg-h70-birth-cohort-study
#19
JOURNAL ARTICLE
Anna Dittrich, Eric Westman, Sara Shams, Tobias Skillbäck, Henrik Zetterberg, Kaj Blennow, Anna Zettergren, Ingmar Skoog, Silke Kern
OBJECTIVES: To determine the prevalence of individuals with Alzheimer disease (AD) eligible for treatment with the recently FDA-approved lecanemab based on data from a population-based sample of 70-year-olds and extrapolate an estimation of individuals eligible in Europe and the United States. METHODS: Participants from the Gothenburg H70 Birth Cohort Study with clinical data, CSF-amyloid beta 42, and brain MRI analysis were evaluated for eligibility to receive lecanemab treatment according to FDA-approved recommendations, noting factors requiring special consideration...
May 14, 2024: Neurology
https://read.qxmd.com/read/38579185/teaching-neuroimage-selenium-toxicity-causing-cerebellar-lesions-with-sparing-of-dentate-nucleus
#20
JOURNAL ARTICLE
Tao Lei, Jingjing Peng, Jianwen Yang, Jibao Wu
No abstract text is available yet for this article.
May 14, 2024: Neurology
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