Neurology

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No abstract text is available yet for this article.

OBJECTIVE: To describe risk and risk factors of epilepsy after hospitalization for brain infection in adults in Sweden. METHODS: A matched retrospective cohort study based on the comprehensive National Patient and Cause of Death Registers. All individuals age >18 without prior epilepsy that received inpatient care in 2000-2010 for a brain infection were included, with 3 age- and gender matched unexposed controls per exposed individual (n = 12,101 exposed and 36,228 controls)...

OBJECTIVE: To determine whether vascular risk and AD biomarkers have independent or synergistic effects on cognitive decline, and whether vascular risk is associated with the accumulation of AD pathology, as measured by change in biomarkers over time. METHODS: At baseline, participants (N = 168) were cognitively normal and primarily middle-aged (M = 56.4, SD = 10.9), and had both vascular risk factor status and proximal CSF biomarkers available. Baseline vascular risk was quantified with a composite vascular risk score reflecting the presence or absence of: hypertension, hypercholesterolemia, diabetes, current smoking, and obesity...

OBJECTIVE: Here we aim to characterize 2 unrelated patients with either asymmetric or unilateral muscle weakness at the clinical, genetic, histological, and ultrastructural level. METHODS: The patients underwent thorough clinical examination, whole-body MRI, and exome sequencing. The muscle morphology was assessed by histology and electron microscopy. RESULTS: Both patients presented with early-onset hypotonia, delayed motor milestones, scoliosis, and reduced pulmonary function...

OBJECTIVE: To characterize longitudinal MRI and PET abnormalities in autopsy confirmed Pick's disease (PiD) and determine how patterns of neurodegeneration differ with respect to clinical syndrome. METHODS: Seventeen patients with PiD were identified who had antemortem MRI (8 with behavioral variant frontotemporal dementia [bvFTD-PiD], 6 with non-fluent/agrammatic primary progressive aphasia [naPPA-PiD], one with semantic primary progressive aphasia, one with unclassified primary progressive aphasia, and one with corticobasal syndrome)...

OBJECTIVE: In a multi-center cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that amyloid-β and tau biomarker positivity increases with age, which is modified by APOE genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype. METHODS: We included 417 DLB patients (45-93 years, 31% women). Positivity on amyloid-β (A+) and tau (T+) biomarkers was determined by cerebrospinal fluid amyloid-β 1-42 and phosphorylated tau in the European cohort, and Pittsburgh compound-B and AV-1451 positron emission tomography in the Mayo Clinic cohort...

OBJECTIVE: To determine whether a fraction of patients with primary CNS lymphoma (PCNSL) had been cured by systemic and intraventricular methotrexate (MTX)- and cytarabine (AraC)-based chemotherapy (Bonn protocol) after a very long-term follow-up of nearly 20 years METHODS: Sixty-five patients (median age 62 years, range 27-75; median Karnofsky performance score 70, range 20-90) had been treated with systemic and intraventricular polychemotherapy without whole brain radiotherapy from September 1995 until December 2001...

OBJECTIVE: To elucidate longitudinal changes in the dopamine transporter (DAT) availability in association with the prodromal markers in idiopathic rapid-eye-movement sleep behavior disorder (iRBD), we analyzed a longitudinal prospective iRBD cohort data. METHOD: The study cohort consisted of iRBD, Parkinson's disease (PD) patients and healthy controls. All participants were evaluated for olfaction, neuropsychological tests, the Movement disorders society-Unified Parkinson's disease Rating Scale and underwent 18 F-FP-CIT PET scans every 2 years...

OBJECTIVE: To test the hypothesis that degree of frailty and neuropathologic burden independently contribute to global cognition and odds of dementia. METHODS: This was a secondary analysis of a prospective cohort study of older adults living in Illinois, USA. Participants underwent an annual neuropsychological and clinical evaluation. We included 625 participants (mean age 89.7 ± 6.1 years; 67.5% female) who died and had autopsy. We quantified neuropathology using an index measure of 10 neuropathologic features: β-amyloid deposition, hippocampal sclerosis, Lewy bodies, tangle density, TDP-43, cerebral amyloid angiopathy, arteriolosclerosis, atherosclerosis, gross and chronic cerebral infarcts...

OBJECTIVE: To determine whether the GGC repeats in the NOTCH2NLC gene contribute to amyotrophic lateral sclerosis (ALS). METHODS: In this study, 545 ALS patients and 1,305 healthy controls from mainland China were recruited. Several pathogenic mutations in known ALS-causative genes (including C9ORF72 and ATXN2 ) and polynucleotide repeat expansions in NOP56 and AR genes were excluded. Repeat-primed PCR (RP-PCR) and GC-rich PCR were performed to determine the GGC repeat size in NOTCH2NLC ...

OBJECTIVE: The aim of the current study was to explore the hypothesis that earlier administration of acute gabapentoids is beneficial to motor recovery after spinal cord injury in humans. METHODS: This is an observational study using a cohort from the European Multi-Centre Study about Spinal Cord Injury. Patient charts were reviewed to extract information regarding the administration and timing of gabapentinoid anticonvulsants. The primary outcome measure was motor scores, as measured by the International Standards for Neurological Classification of Spinal Cord Injury, collected longitudinally in the first year after injury...

BACKGROUND: Endovascular thrombectomy (EVT) is highly effective for acute ischemic stroke with large vessel occlusion (LVO) and moderate to severe neurologic deficits. OBJECTIVE: To undertake an effectiveness and safety analysis of EVT in patients with LVO and NIHSS ≤6 using datasets of multicentre and multinational nature. METHODS: We pooled patients with anterior circulation occlusion from 3 prospective international cohorts. Patients were eligible if presentation occurred within 12 hours from last known well and baseline NIHSS ≤6...

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OBJECTIVE: To investigate whether p-tau T217 assay in cerebrospinal fluid (CSF) can distinguish Alzheimer's disease from other dementias and healthy controls. METHODS: We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. There was a total of 190 participants from three cohorts with AD (n = 77) and other neurodegenerative diseases (n = 69) as well as healthy subjects (n = 44). RESULTS: The p-tau T217 assay (cut-off 242 pg/ml) identified AD subjects with accuracy of 90%, with 78% positive predictive value (PPV), 97% negative predictive value (NPV), 93% sensitivity, 88% specificity compared favorably with p-tau T181 ELISA (52 pg/ml) showing 78% accuracy, 58% PPV, 98% NPV, 71% specificity, 97% sensitivity...

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OBJECTIVE: We conducted a nationwide case-control study in Sweden to test the hypothesis that antiepileptic drugs (AEDs), mono- polytherapy, adherence, antidepressants, neuroleptics, beta-blockers, and statins are associated with sudden unexpected death in epilepsy (SUDEP) risk. METHODS: Included were 255 SUDEP cases and 1148 matched controls. Information on clinical factors and medications came from medical records and the National Patient and Prescription Registers...

No abstract text is available yet for this article.

No abstract text is available yet for this article.