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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 30, 2022: Neurology
#2
EDITORIAL
A Gordon Smith
No abstract text is available yet for this article.
November 30, 2022: Neurology
#3
JOURNAL ARTICLE
Amir Khakban, Elisabet Rodriguez Llorian, Kristina D Michaux, Scott B Patten, Anthony Traboulsee, Jiwon Oh, Larry D Lynd
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS), a leading cause of non-traumatic neurologic disability in young adults, exerts a substantial economic burden on the healthcare system. The objective of this study was to quantify the excess healthcare costs of MS in British Columbia (BC), Canada. METHODS: A retrospective matched-cohort study of MS patients was conducted using population-based administrative health data from 2001 to 2020. MS patients who satisfied a validated case-definition were matched to five unique controls without MS on sex, age, and cohort-entry date...
November 30, 2022: Neurology
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JOURNAL ARTICLE
Zi-Ran Li, Chen-Yu Wang, Wei-Wei Lin, Yue-Ting Chen, Xiao-Qin Liu, Zheng Jiao
BACKGROUND AND OBJECTIVES: Antiseizure medications are the major treatment modality for patients with epilepsy. Delayed or missed doses are common during long-term or lifelong anti-epilepsy treatment. This study aims to explore optimal individualized remedial dosing regimens for delayed or missed doses of 11 commonly used antiseizure medications. METHODS: In order to explore remedial dosing regimens, Monte Carlo simulation was employed based on previously identified and published population pharmacokinetic models...
November 30, 2022: Neurology
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JOURNAL ARTICLE
Silvia Chapman, Miguel Arce Rentería, Jordan D Dworkin, Stella M Garriga, Megan S Barker, Justina Avila-Rieger, Christopher Gonzalez, Jillian L Joyce, Jet M J Vonk, Elizabeth Soto, Jennifer J Manly, Adam Brickman, Richard Mayeux, Stephanie A Cosentino
BACKGROUND AND OBJECTIVES: This prospective study seeks to examine the utility of SCD as a marker of future progression to dementia in a community-based cohort of non-Latinx White, non-Latinx Black and Latinx individuals. Debate surrounds the utility of Subjective Cognitive Decline (SCD), the subjective perception of decline in one's cognition before such impairment is evident in traditional neuropsychological assessments, as an early indicator of impending Alzheimer's disease. Unfortunately, most studies examining SCD have been conducted in non-Latinx White samples and commonly exclude groups of individuals shown to be most vulnerable to dementia...
November 30, 2022: Neurology
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JOURNAL ARTICLE
Jordi Sarto, Raquel Ruiz-García, Núria Guillén, Óscar Ramos-Campoy, Neus Falgàs, Diana Esteller, José Contador, Guadalupe Fernández, Yolanda González, Adrià Tort-Merino, Jordi Juncà-Parella, Bea Bosch, Sergi Borrego-Écija, Laura Molina-Porcel, Magda Castellví, Miguel Vergara, Anna Antonell, Josep María Augé, Laura Naranjo, Raquel Sanchez-Valle, Albert Lladó, Mircea Balasa
BACKGROUND AND OBJECTIVES: Blood-based biomarkers have emerged as minimally-invasive options for evaluating cognitive impairment. Most studies to date have assessed them in research cohorts, limiting their generalization to everyday clinical practice. We evaluated their diagnostic performance and clinical applicability in a prospective, real-world, memory clinic cohort. METHODS: All patients referred with suspected cognitive impairment between July 2019 and June 2021, were prospectively invited to participate...
November 30, 2022: Neurology
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JOURNAL ARTICLE
Joel D Handley, Sachin Mathur, Suresh K Chhetri
Bilateral optic disc swelling is a common finding but rarely associated with multiple cranial neuropathies. In this case, an 18-year-old male presented with subacute sequential hearing loss followed by subacute sequential visual loss. Clinical examination revealed bilateral optic disc swelling. Lumbar puncture revealed a normal opening pressure of 15 cmH2 o. This case discusses a rare but important cause of bilateral optic disc swelling in the context of hearing loss, disequilibrium and a normal CSF opening pressure...
November 30, 2022: Neurology
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JOURNAL ARTICLE
XiaoYang Lei, Ying Liu, Feng Han, Hui Yu, ChaoNan Deng, Dian He
No abstract text is available yet for this article.
November 30, 2022: Neurology
#9
JOURNAL ARTICLE
Evan L Reynolds, Gary Gallagher, Chloe E Hill, Mousumi Banerjee, Aristotle Mante, Gregory J Esper, Brian C Callaghan
BACKGROUND AND OBJECTIVES: To compare the utilization and costs (total and out-of-pocket) of new-to-market neurologic medications with existing guideline-supported neurologic medications over time. METHODS: We used a healthcare pharmaceutical claims database (from 2001-2019) to identify patients with both a diagnosis of one of 11 separate neurologic conditions and either a new-to-market medication or an existing guideline-supported medication for that condition...
November 30, 2022: Neurology
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JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 29, 2022: Neurology
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 29, 2022: Neurology
#12
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 29, 2022: Neurology
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JOURNAL ARTICLE
Gianmaria Senerchia, Valentina Iuzzolino, Stefano Zoccolella, Lorenzo Ugga, Rosa Iodice, Fiore Manganelli, Raffaele Dubbioso
No abstract text is available yet for this article.
November 29, 2022: Neurology
#14
JOURNAL ARTICLE
Kumar Rajan, Elizabeth A McAninch, Neelum Aggarwal, Lisa L Barnes, Robert Wilson, Jennifer Weuve, Charles S DeCarli, Denis Evans
BACKGROUND AND OBJECTIVES: Recent studies suggest the utility of blood biomarkers in detecting changes in neurodegenerative disorders. The objective of our research is to test the hypothesis that the longitudinal changes in total tau (t-tau), neurofilament light (Nf-L), and glial fibrillary acidic protein (GFAP) is associated with structural MRI and the development of clinical Alzheimer's disease (AD), and cognitive decline. METHODS: Data came from a population-based sample with serum concentrations of t-tau, Nf-L, and GFAP and cognitive characteristics measured over 17 years...
November 29, 2022: Neurology
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JOURNAL ARTICLE
Martin Bretzner, Anna K Bonkhoff, Markus D Schirmer, Sungmin Hong, Adrian Dalca, Kathleen Donahue, Anne-Katrin Giese, Mark R Etherton, Pamela M Rist, Marco Nardin, Robert W Regenhardt, Xavier Leclerc, Renaud Lopes, Morgan Gautherot, Clinton Wang, Oscar R Benavente, John W Cole, Amanda Donatti, Christoph Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J Kittner, Robin Lemmens, Christopher R Levi, Patrick F McArdle, Caitrin W McDonough, James F Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ona Wu, Ramin Zand, Bradford B Worrall, Jane Maguire, Arne G Lindgren, Christina Jern, Polina Golland, Grégory Kuchcinski, Natalia S Rost
BACKGROUND AND OBJECTIVES: While chronological age is one of the most influential determinants of post-stroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age". We hypothesized that radiomics analyses of T2-FLAIR images texture would provide brain age estimates and that advanced brain age of stroke patients will be associated with cardiovascular risk factors and worse functional outcomes. METHODS: We extracted radiomics from T2-FLAIR images acquired during acute stroke clinical evaluation...
November 28, 2022: Neurology
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JOURNAL ARTICLE
John P Welsh, Jeffrey Munson, Tanya St John, Christina N Meehan, Elise N Tran Abraham, Fritz Reitz, K Kawena Begay, Stephen R Dager, Annette M Estes
BACKGROUND AND OBJECTIVES: The severity of autism spectrum disorder (ASD) varies widely and is associated with intellectual disability (ID) and brain dysmorphology. We tested the hypothesis that the heterogeneity of ASD can be accounted for, in part, by altered associative learning measured by eye-blink conditioning (EBC) paradigms, used to test for forebrain and cerebellar dysfunction across the full range of ASD severity and intellectual ability. METHODS: Children in this cohort study were diagnosed with ASD or typical development (TD); most children were recruited from a 10-year longitudinal study...
November 28, 2022: Neurology
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JOURNAL ARTICLE
Kristin Geczi
In medical school, students learn to view the world through a biomedical lens. While necessary clinically, this lens can be impersonal. For example, the mental status examination (MSE) evaluates cognitive function through a brief assessment of alertness and orientation to person, place, time, and situation. While clinically useful, the MSE often neglects to capture a person's individuality. Visiting with my grandmother who has Alzheimer's Disease highlighted this tension. I juxtaposed the impersonality of our MSE orientation scale with my grandmother's lived experiences...
November 28, 2022: Neurology
#18
JOURNAL ARTICLE
Thomas Bonduelle, Morgan Ollivier, Kilian Trin, Benjamin Thomas, Antoine Daubigney, Veronique Michel, Marie De Montaudouin, Cécile Marchal, Jérôme Aupy
BACKGROUND AND OBJECTIVES: Status epilepticus (SE) is a life-threatening emergency requiring a prompt assessment of patient prognosis to guide management. Magnetic resonance imaging (MRI) allows the identification of peri-ictal MRI abnormalities (PMA) and provides insight into brain structural modifications induced by SE. However, little is known about the significance of PMA in SE prognosis. The aim of this study was to determine whether PMA are associated with an increased mortality in SE, and to establish the association between PMA and refractoriness to antiseizure medications, complications encountered and induced morbidity...
November 28, 2022: Neurology
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JOURNAL ARTICLE
Jamison Seabury, Danae Alexandrou, Nuran Dilek, Brittany Cohen, John Heatwole, Jane Larkindale, David R Lynch, Courtney Park, Spencer Rosero, Sub H Subramony, Anika Varma, Ellen Wagner, Susan Walther, Jennifer Weinstein, McKenzie Wells, Christine Zizzi, Chad Heatwole
OBJECTIVE: To determine the prevalence and relative importance of symptoms experienced by children and adults with Friedreich's ataxia (FA) and to identify factors associated with a higher burden of disease. METHODS: We conducted qualitative interviews with individuals with FA and caregivers of pediatric individuals with FA to identify potential symptoms of importance to those living with FA. We subsequently performed a cross-sectional study to assess which symptoms have the highest prevalence and importance in FA and to determine which factors are associated with a higher burden of disease...
November 28, 2022: Neurology
#20
JOURNAL ARTICLE
Daniel Ferreira, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Patricia Diaz-Galvan, Jonathan Graff-Radford, Matthew L Senjem, Julie A Fields, David S Knopman, David T Jones, Rodolfo Savica, Tanis J Ferman, Neill Graff-Radford, Val J Lowe, Clifford R Jack, Ronald C Petersen, Eric Westman, Brad F Boeve, Kejal Kantarci
BACKGROUND AND OBJECTIVES: Although alpha-synuclein-related pathology is the hallmark of dementia with Lewy bodies (DLB), cerebrovascular and AD pathologies are common in DLB patients. Little is known about the contribution of these pathologies to neurodegeneration in DLB. We investigated associations of cerebrovascular, β-amyloid, and tau biomarkers with gray matter (GM) volume in probable DLB patients. METHODS: We assessed probable DLB patients and cognitively unimpaired (CU) controls with 11C-Pittsburgh Compound-B (PiB) and 18F-Flortaucipir positron emission tomography (PET), as markers of β-amyloid and tau, respectively...
November 28, 2022: Neurology
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