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William J Culpepper, Ruth Ann Marrie, Annette Langer-Gould, Mitchell T Wallin, Jonathan D Campbell, Lorene M Nelson, Wendy E Kaye, Laurie Wagner, Helen Tremlett, Lie H Chen, Stella Leung, Charity Evans, Shenzhen Yao, Nicholas G LaRocca
OBJECTIVE: To develop a valid algorithm for identifying multiple sclerosis (MS) cases in administrative health claims (AHC) datasets. METHODS: We used 4 AHC datasets from the Veterans Administration (VA), Kaiser Permanente Southern California (KPSC), Manitoba (Canada), and Saskatchewan (Canada). In the VA, KPSC, and Manitoba, we tested the performance of candidate algorithms based on inpatient, outpatient, and disease-modifying therapy (DMT) claims compared to medical records review using sensitivity, specificity, positive and negative predictive values, and interrater reliability (Youden J statistic) both overall and stratified by sex and age...
February 15, 2019: Neurology
Marios K Georgakis, Marco Duering, Joanna M Wardlaw, Martin Dichgans
OBJECTIVE: To investigate the relationship between baseline white matter hyperintensities (WMH) in patients with ischemic stroke and long-term risk of dementia, functional impairment, recurrent stroke, and mortality. METHODS: Following the Meta-analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO protocol: CRD42018092857), we systematically searched Medline and Scopus for cohort studies of ischemic stroke patients examining whether MRI- or CT-assessed WMH at baseline are associated with dementia, functional impairment, recurrent stroke, and mortality at 3 months or later poststroke...
February 15, 2019: Neurology
Mitchell T Wallin, William J Culpepper, Jonathan D Campbell, Lorene M Nelson, Annette Langer-Gould, Ruth Ann Marrie, Gary R Cutter, Wendy E Kaye, Laurie Wagner, Helen Tremlett, Stephen L Buka, Piyameth Dilokthornsakul, Barbara Topol, Lie H Chen, Nicholas G LaRocca
OBJECTIVE: To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets. METHODS: A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 2008 and 2010. In each dataset, we determined the 3-year cumulative prevalence overall and stratified by age, sex, and census region. We applied insurance-specific and stratum-specific estimates to the 2010 US Census data and pooled the findings to calculate the 2010 prevalence of MS in the United States cumulated over 3 years...
February 15, 2019: Neurology
Rachel H Tan, Boris Guennewig, Carol Dobson-Stone, John B J Kwok, Jillian J Kril, Matthew C Kiernan, John R Hodges, Olivier Piguet, Glenda M Halliday
OBJECTIVE: To assess the incidence, heritability, and neuropathology of primary progressive aphasia (PPA) with amyotrophic lateral sclerosis (ALS) in a large Australian cohort. METHODS: A total of 130 patients with a primary nonfluent variant of PPA (nfvPPA) or semantic variant of PPA (svPPA) were assessed for concomitant ALS and a strong family history of neurodegenerative diseases (Goldman score ≤3). Neuropathologic examination was carried out in 28% (n = 36) of these PPA and PPA-ALS cases that had come to autopsy...
February 15, 2019: Neurology
Susanna C Larsson, Leon Flicker
No abstract text is available yet for this article.
February 15, 2019: Neurology
Aleksandar Videnovic, Lambros Messinis
No abstract text is available yet for this article.
February 15, 2019: Neurology
Sonja Rutten, Chris Vriend, Jan H Smit, Henk W Berendse, Eus J W van Someren, Adriaan W Hoogendoorn, Jos W R Twisk, Ysbrand D van der Werf, Odile A van den Heuvel
OBJECTIVE: To assess the efficacy of bright light therapy (BLT) in reducing depressive symptoms in patients with Parkinson disease (PD) and major depressive disorder (MDD) compared to a control light. METHODS: In this double-blind controlled trial, we randomized patients with PD and MDD to treatment with BLT (±10,000 lux) or a control light (±200 lux). Participants were treated for 3 months, followed by a 6-month naturalistic follow-up. The primary outcome of the study was the Hamilton Depression Rating Scale (HDRS) score...
February 15, 2019: Neurology
Jason H Huang, Xiaoming Qi
No abstract text is available yet for this article.
February 15, 2019: Neurology
Kirsty Bowman, Lindsay Jones, Luke C Pilling, João Delgado, George A Kuchel, Luigi Ferrucci, Richard H Fortinsky, David Melzer
OBJECTIVE: To estimate effects of vitamin D levels on incident delirium hospital admissions using inherited genetic variants in mendelian randomization models, which minimize confounding and exclude reverse causation. METHODS: Longitudinal analysis using the UK Biobank, community-based, volunteer cohort (2006-2010) with incident hospital-diagnosed delirium (ICD-10 F05) ascertained during ≤9.9 years of follow-up of hospitalization records (to early 2016). We included volunteers of European descent aged 60-plus years by end of follow-up...
February 15, 2019: Neurology
Gergely David, Maryam Seif, Eveline Huber, Markus Hupp, Jan Rosner, Volker Dietz, Nikolaus Weiskopf, Siawoosh Mohammadi, Patrick Freund
OBJECTIVE: To characterize remote secondary neurodegeneration of spinal tracts and neurons below a cervical spinal cord injury (SCI) and its relation to the severity of injury, the integrity of efferent and afferent pathways, and clinical impairment. METHODS: A comprehensive high-resolution MRI protocol was acquired in 17 traumatic cervical SCI patients and 14 controls at 3T. At the cervical lesion, a sagittal T2-weighted scan provided information on the width of preserved midsagittal tissue bridges...
February 15, 2019: Neurology
Lorene M Nelson, Mitchell T Wallin, Ruth Ann Marrie, W J Culpepper, Annette Langer-Gould, Jon Campbell, Stephen Buka, Helen Tremlett, Gary Cutter, Wendy Kaye, Laurie Wagner, Nicholas G Larocca
OBJECTIVE: Considerable gaps exist in knowledge regarding the prevalence of neurologic diseases, such as multiple sclerosis (MS), in the United States. Therefore, the MS Prevalence Working Group sought to review and evaluate alternative methods for obtaining a scientifically valid estimate of national MS prevalence in the current health care era. METHODS: We carried out a strengths, weaknesses, opportunities, and threats (SWOT) analysis for 3 approaches to estimate MS prevalence: population-based MS registries, national probability health surveys, and analysis of administrative health claims databases...
February 15, 2019: Neurology
Peng Soon Ng, Peter J Dyck, Ruple S Laughlin, Prabin Thapa, Marcus V Pinto, P James B Dyck
OBJECTIVE: To determine the previously unknown incidence of lumbosacral-radiculoplexus neuropathy (LRPN) and its association with diabetes mellitus (DM). METHODS: LRPN defined by clinical and electrophysiologic criteria was identified among Olmsted County, Minnesota, residents during a 16-year period (2000-2015) using the unique facilities of the Rochester Epidemiology Project. DM was ascertained using American Diabetes Association criteria. RESULTS: Of 1,892 medical records reviewed, 59 patients (33 men, 26 women) were identified as having LRPN...
February 13, 2019: Neurology
Michael W Ruff, Joon H Uhm, Eduardo E Benarroch
The field of neuro-oncology has recently experienced a renaissance in the understanding of the molecular underpinnings and pathophysiology of glioma. Genetic markers have significant implications regarding treatment responsiveness and prognosis and are now the primary basis for classification. This article gives an updated understanding of the pathogenesis and mechanisms of resistance of glioma via discussion of 4 molecular and genetic markers: MGMT, IDH , 1p/19q, and TERT .
February 13, 2019: Neurology
Peter S Pressman, Kelly Gola, Suzanne M Shdo, Bruce L Miller, Carolyn Fredericks, Clinton Mielke, Victoria Pelak, Katherine P Rankin
OBJECTIVE: To compare recognition of facial expression (FE) vs recognition of facial identity (FI) in posterior cortical atrophy (PCA), with the hypothesis that FE recognition would be relatively preserved in PCA. METHODS: In this observational study, FI and expression recognition tasks were performed by 194 participants in 4 groups, including 39 with Alzheimer disease (AD) (non-PCA), 49 with behavioral variant frontotemporal dementia (bvFTD), 15 with PCA, and 91 healthy controls...
February 13, 2019: Neurology
Keenan A Walker, Rebecca F Gottesman, Aozhou Wu, David S Knopman, Alden L Gross, Thomas H Mosley, Elizabeth Selvin, B Gwen Windham
OBJECTIVE: To examine the association between systemic inflammation measured during midlife and 20-year cognitive decline. METHODS: Within the Atherosclerosis Risk in Communities cohort study, inflammatory biomarkers were measured during middle adulthood. We created an inflammation composite score using 4 blood biomarkers measured at visit 1 (fibrinogen, white blood cell count, von Willebrand factor, and factor VIII); we measured C-reactive protein (CRP) at visit 2...
February 13, 2019: Neurology
Stefan Wolking, Patrick May, Davide Mei, Rikke S Møller, Simona Balestrini, Katherine L Helbig, Cecilia Desmettre Altuzarra, Nicolas Chatron, Charu Kaiwar, Katharina Stöhr, Peter Widdess-Walsh, Bryce A Mendelsohn, Adam Numis, Maria R Cilio, Wim Van Paesschen, Lene L Svendsen, Stephanie Oates, Elaine Hughes, Sushma Goyal, Kathleen Brown, Margarita Sifuentes Saenz, Thomas Dorn, Hiltrud Muhle, Alistair T Pagnamenta, Dimitris V Vavoulis, Samantha J L Knight, Jenny C Taylor, Maria Paola Canevini, Francesca Darra, Ralitza H Gavrilova, Zöe Powis, Shan Tang, Justus Marquetand, Martin Armstrong, Duncan McHale, Eric W Klee, Gerhard J Kluger, Daniel H Lowenstein, Sarah Weckhuysen, Deb K Pal, Ingo Helbig, Renzo Guerrini, Rhys H Thomas, Mark I Rees, Gaetan Lesca, Sanjay M Sisodiya, Yvonne G Weber, Dennis Lal, Carla Marini, Holger Lerche, Julian Schubert
OBJECTIVE: The aim of this study was to expand the spectrum of epilepsy syndromes related to STX1B , encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants. METHODS: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. To estimate the pathogenicity of the variants, we used established and newly developed in silico prediction tools...
February 8, 2019: Neurology
Jonathan Tay, Anil M Tuladhar, Matthew J Hollocks, Rebecca L Brookes, Daniel J Tozer, Thomas R Barrick, Masud Husain, Frank-Erik de Leeuw, Hugh S Markus
OBJECTIVE: To investigate whether white matter network disruption underlies the pathogenesis of apathy, but not depression, in cerebral small vessel disease (SVD). METHODS: Three hundred thirty-one patients with SVD from the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) study completed measures of apathy and depression and underwent structural MRI. Streamlines reflecting underlying white matter fibers were reconstructed with diffusion tensor tractography...
February 8, 2019: Neurology
Chiung-Chu Chen
No abstract text is available yet for this article.
February 8, 2019: Neurology
Vincent Planche, Sylvain Vergnet, Nicolas Auzou, Marie Bonnet, Thomas Tourdias, François Tison
No abstract text is available yet for this article.
February 8, 2019: Neurology
W M Michael Schuepbach, Lisa Tonder, Alfons Schnitzler, Paul Krack, Joern Rau, Andreas Hartmann, Thomas Hälbig, Fanny Pineau, Andrea Falk, Laura Paschen, Stephen Paschen, Jens Volkmann, Haidar S Dafsari, Michael T Barbe, Gereon R Fink, Andrea Kühn, Andreas Kupsch, Gerd-H Schneider, Eric Seigneuret, Valerie Fraix, Andrea Kistner, P Patrick Chaynes, Fabienne Ory-Magne, Christine Brefel-Courbon, Jan Vesper, Lars Wojtecki, Stéphane Derrey, David Maltête, Philippe Damier, Pascal Derkinderen, Friederike Sixel-Döring, Claudia Trenkwalder, Alireza Gharabaghi, Tobias Wächter, Daniel Weiss, Marcus O Pinsker, Jean-Marie Regis, Tatiana Witjas, Stephane Thobois, Patrick Mertens, Karina Knudsen, Carmen Schade-Brittinger, Jean-Luc Houeto, Yves Agid, Marie Vidailhet, Lars Timmermann, Günther Deuschl
OBJECTIVE: To investigate predictors for improvement of disease-specific quality of life (QOL) after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson disease (PD) with early motor complications. METHODS: We performed a secondary analysis of data from the previously published EARLYSTIM study, a prospective randomized trial comparing STN-DBS (n = 124) to best medical treatment (n = 127) after 2 years follow-up with disease-specific QOL (39-item Parkinson's Disease Questionnaire summary index [PDQ-39-SI]) as the primary endpoint...
February 8, 2019: Neurology
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