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Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation.
Bone Marrow Transplantation 1999 June
This case describes a 16-year-old woman treated successfully by a bone marrow transplant from her HLA-identical brother for refractory acquired pure red cell aplasia. Conditioning was as for severe aplastic anaemia with cyclophosphamide 4 x 50 mg/kg and antithymocyte globulin. Complete donor type engraftment at 3 months reversed to full autologous reconstitution at 2 years with normal haemopoiesis. The potential implications on pathogenesis of the disease as well as on treatment of autoimmune disorders by stem cell transplantation are discussed.
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