journal
https://read.qxmd.com/read/37730801/allogeneic-hematopoietic-stem-cell-transplantation-for-adult-acute-myeloid-leukemia-patients-with-nucleoporin-98-nup98-gene-rearrangements-a-real-world-study-in-china
#1
LETTER
Yang Cao, Chunli Zhang, Xiaosu Zhao, Jiayu Huang, Zilu Zhang, Chuanhe Jiang, Xiaodong Mo, Xiaoxia Hu
No abstract text is available yet for this article.
September 20, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37730800/understanding-and-treatment-of-cutaneous-graft-versus-host-disease
#2
REVIEW
Junshik Hong, Johnathan Fraebel, Yenny Yang, Eric Tkacyk, Carrie Kitko, Tae Kon Kim
The skin is the outermost mechanical barrier where dynamic immune reactions take place and is the most commonly affected site in both acute and chronic graft-versus-host disease (GVHD). If not properly treated, pain and pruritis resulting from cutaneous GVHD can increase the risk of secondary infection due to erosions, ulcerations, and damage of underlying tissues. Furthermore, resulting disfiguration can cause distress and significantly impact patients' quality of life. Thus, a deeper understanding of skin-specific findings of GVHD is needed...
September 20, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37726490/hematopoietic-cell-transplantation-can-be-safely-performed-after-covid-19
#3
LETTER
Alejandro Marinos, Jeremy Ramdial, Fareed Khawaja, Rima M Saliba, Terri Lynn Shigle, Amin M Alousi, Gabriela Rondon, Julianne Chen, Celina Ledesma, Richard E Champlin, May Daher, George Chen, David Marin, Katayoun Rezvani, Elizabeth J Shpall, Roy F Chemaly
No abstract text is available yet for this article.
September 19, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37714944/third-hla-haploidentical-stem-cell-transplantation-using-post-transplant-cyclophosphamide-for-relapsed-acute-leukemia
#4
LETTER
Naonori Harada, Hiroshi Okamura, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Mika Nakamae, Mitsutaka Nishimoto, Yasuhiro Nakashima, Hideo Koh, Masayuki Hino, Hirohisa Nakamae
No abstract text is available yet for this article.
September 15, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37699993/the-association-of-body-composition-and-outcomes-following-autologous-hematopoietic-stem-cell-transplantation-in-patients-with-non-hodgkin-lymphoma
#5
JOURNAL ARTICLE
Gabriel F P Aleixo, Wei Wei, Po-Hao Chen, Namita S Gandhi, Faiz Anwer, Robert Dean, Betty K Hamilton, Brian T Hill, Deepa Jagadeesh, Jack Khouri, Brad Pohlman, Ronald Sobecks, Allison Winter, Paolo Caimi, Navneet S Majhail
Recently there has been a growing interest in evaluating body composition as a marker for prognosis in cancer patients. The association of body composition parameters and outcomes has not been deeply investigated in patients with autologous hematopoietic stem cell transplantation (HSCT) recipients with non-Hodgkin lymphoma (NHL). We conducted a retrospective cohort study of 264 NHL patients who received autologous HSCT. PreHSCT abdominal CT scans at the levels of L3 were assessed for body composition measures...
September 12, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37684526/metabolic-syndrome-prevalence-and-impact-on-outcomes-in-patients-with-chronic-graft-versus-host-disease
#6
JOURNAL ARTICLE
Aaron T Zhao, Filip Pirsl, Seth M Steinberg, Noa G Holtzman, Eduard Schulz, Alain Mina, Jacqueline W Mays, Edward W Cowen, Leora E Comis, Galen O Joe, Jack A Yanovski, Steven Z Pavletic
Patients with chronic graft-versus-host disease (cGVHD) are at heightened risk for components of metabolic syndrome (MetS), yet the prevalence and impact of MetS in the cGVHD patient population remain unknown. Adult patients (n = 229) with cGVHD enrolled in the cross-sectional NIH cGVHD Natural History Study (NCT00092235) were evaluated for MetS at enrollment and for variables associated with MetS. A majority (54.1%, 124/229) of the cohort met the diagnostic criteria for MetS. Patients with higher body mass index and lower performance status scores were more likely to have MetS (P < 0...
September 8, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37679647/allogeneic-hematopoietic-cell-transplantation-in-patients-with-calr-mutated-myelofibrosis-a-study-of-the-chronic-malignancies-working-party-of-ebmt
#7
JOURNAL ARTICLE
Juan Carlos Hernández-Boluda, Diderik-Jan Eikema, Linda Koster, Nicolaus Kröger, Marie Robin, Moniek de Witte, Jürgen Finke, Maria Chiara Finazzi, Annoek Broers, Ludek Raida, Nicolaas Schaap, Patrizia Chiusolo, Mareike Verbeek, Carin L E Hazenberg, Kazimierz Halaburda, Aleksandr Kulagin, Hélène Labussière-Wallet, Tobias Gedde-Dahl, Werner Rabitsch, Kavita Raj, Joanna Drozd-Sokolowska, Giorgia Battipaglia, Nicola Polverelli, Tomasz Czerw, Ibrahim Yakoub-Agha, Donal P McLornan
Allogeneic hematopoietic cell transplantation (allo-HCT) is curative for myelofibrosis (MF) but assessing risk-benefit in individual patients is challenging. This complexity is amplified in CALR-mutated MF patients, as they live longer with conventional treatments compared to other molecular subtypes. We analyzed outcomes of 346 CALR-mutated MF patients who underwent allo-HCT in 123 EBMT centers between 2005 and 2019. After a median follow-up of 40 months, the estimated overall survival (OS) rates at 1, 3, and 5 years were 81%, 71%, and 63%, respectively...
September 7, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37679646/thrombopoietin-level-predicts-the-response-to-avatrombopag-treatment-for-persistent-thrombocytopenia-after-haploidentical-haematopoietic-stem-cell-transplantation
#8
JOURNAL ARTICLE
Haixia Fu, Meng Lv, Huixin Liu, Yuqian Sun, Yuanyuan Zhang, Xiaodong Mo, Tingting Han, Fengrong Wang, Chenhua Yan, Yu Wang, Jun Kong, Wei Han, Huan Chen, Yao Chen, Yuhong Chen, Lanping Xu, Kaiyan Liu, Xiaojun Huang, Xiaohui Zhang
Persistent thrombocytopenia (PT) has an unsatisfactory response to therapy after haploidentical haematopoietic stem cell transplantation (haplo-HSCT). We retrospectively evaluated the safety and efficacy of avatrombopag treatment in 69 patients with PT following haplo-HSCT and assessed whether baseline thrombopoietin (TPO) levels could predict treatment response. Overall response (OR) and complete response (CR) were defined as increased platelet levels to over 20 × 109 /L or 50 × 109 /L independent of platelet transfusion during or within 7 days of the end of avatrombopag treatment, respectively...
September 7, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37673983/widening-demographic-gaps-in-car-t-therapy-utilization-for-multiple-myeloma-in-the-united-states
#9
LETTER
Mingqian Lin, Noel Estrada-Merly, Mary Eapen, Anthony E Zamora, Liliana E Pezzin, Aaron N Winn, Joyce Philip, Carolina Schinke, William R Drobyski, Larry D Anderson, Anita D'Souza
No abstract text is available yet for this article.
September 6, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37673982/fresh-or-frozen-grafts-for-allogeneic-stem-cell-transplantation-conceptual-considerations-and-a-survey-on-the-practice-during-the-covid-19-pandemic-from-the-ebmt-infectious-diseases-working-party-idwp-and-cellular-therapy-immunobiology-working-party-ctiwp
#10
JOURNAL ARTICLE
N Worel, P Ljungman, I C M Verheggen, J D Hoogenboom, N S Knelange, D-J Eikema, I Sánchez-Ortega, C Riillo, I Centorrino, D Averbuch, C Chabannon, R de la Camara, J Kuball, A Ruggeri
The COVID-19 pandemic has had a significant impact on medical practices, including the delivery of allogeneic hematopoietic cell transplantation (HCT). In response, transplant centers have made changes to their procedures, including an increased use of cryopreservation for allogeneic haematopoietic progenitor cell (HPC) grafts. The use of cryopreserved grafts for allogeneic HCT has been reviewed and analysed in terms of potential benefits and drawbacks based on existing data on impact on cell subsets, hematological recovery, and clinical outcomes of approximately 2000 patients from different studies...
September 6, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37670048/incidence-and-course-of-epstein-barr-virus-viremia-after-allogeneic-hematopoietic-stem-cell-transplant-for-adult-onset-systemic-chronic-active-epstein-barr-virus-disease
#11
LETTER
Preeti Prerna M Vaswani, Masahiro Onozawa, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Toshihiro Matsukawa, Atsushi Yasumoto, Souichi Shiratori, Hideki Goto, Masao Nakagawa, Kaoru Kahata, Tomoyuki Endo, Daigo Hashimoto, Takanori Teshima
No abstract text is available yet for this article.
September 5, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37666957/no-impact-of-cd34-cell-dose-on-outcome-among-children-undergoing-autologous-hematopoietic-stem-cell-transplant-for-high-risk-neuroblastoma
#12
LETTER
Tristan E Knight, Kwang Woo Ahn, Kyle M Hebert, Rasha Atshan, Donna A Wall, Kanhatai Chiengthong, Troy C Lund, Tim Prestidge, Hemalatha G Rangarajan, Christopher C Dvorak, Jeffery J Auletta, Michael Kent, Hasan Hashem, Julie-An Talano, Seth J Rotz, Ellen Fraint, Kasiani C Myers, Wing Leung, Akshay Sharma, Neel S Bhatt, Timothy A Driscoll, Lolie C Yu, Kirk R Schultz, Muna Qayed, Larisa Broglie, Mary Eapen, Gregory A Yanik
No abstract text is available yet for this article.
September 4, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37666956/impact-of-sars-cov-2-vaccination-and-passive-prophylaxis-with-tixagevimab-cilgavimab-on-car-t-patients-a-three-year-regional-experience-from-the-italian-covid-pandemic
#13
LETTER
Eugenio Galli, Alice Di Rocco, Ilaria Pansini, Federico Frondizi, Martina Di Palma, Elisabetta Metafuni, Nicola Piccirillo, Maria Bianchi, Antonella Cingolani, Giovanni Fernando Torelli, Stefan Hohaus, Patrizia Chiusolo, Anna Paola Iori, Simona Sica, Maurizio Martelli, Federica Sorà
No abstract text is available yet for this article.
September 4, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37660157/the-role-of-anti-thymocyte-globulin-in-allogeneic-stem-cell-transplantation-hsct-from-hla-matched-unrelated-donors-mud-for-secondary-aml-in-remission-a-study-from-the-alwp-ebmt
#14
JOURNAL ARTICLE
Arnon Nagler, Myriam Labopin, Nicolaus Kröger, Thomas Schroeder, Tobias Gedde-Dahl, Matthias Eder, Georg-Nikolaus Franke, Igor Wolfgang Blau, Urpu Salmenniemi, Gerard Socie, Johannes Schetelig, Matthias Stelljes, Fabio Ciceri, Mohamad Mohty
We compared outcomes, of 1609 patients with secondary acute myeloid leukemia (sAML) undergoing allogeneic transplantation (HSCT) in first complete remission (CR1) from matched unrelated donors (MUD) from 2010 to 2021, receiving or not receiving anti-thymocyte globulin (ATG) (ATG-1308, no ATG-301). Median age was 60.9 (range, 18.5-77.8) and 61.1 (range, 21.8-75.7) years, (p = 0.3). Graft versus host disease (GVHD) prophylaxis was cyclosporin-A with methotrexate (41%) or mycophenolate mofetil (38...
September 2, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37653054/allogeneic-hematopoietic-stem-cell-transplantation-for-adults-with-therapy-related-acute-myeloid-leukaemia-a-retrospective-multicentre-study-on-behalf-of-the-sfgm-tc
#15
JOURNAL ARTICLE
Gaëlle Rey, Elisabeth Daguenet, Paul Bonjean, Raynier Devillier, Nathalie Fegueux, Edouard Forcade, Micha Srour, Patrice Chevallier, Marie Robin, Felipe Suarez, Jean-Baptiste Micol, Hélène Labussière-Wallet, Karin Bilger, Etienne Daguindau, Jacques-Olivier Bay, Amandine Fayard, Claude-Eric Bulabois, Stéphanie Nguyen-Quoc, Alexis Genthon, Corentin Orvain, Pascal Turlure, Michael Loschi, Xavier Poiré, Gaëlle Guillerm, Yves Beguin, Natacha Maillard, Jean-Baptiste Mear, Emilie Chalayer, Jérôme Cornillon, Emmanuelle Tavernier
We report the results from a multicentre retrospective study of 220 adult patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) for therapy-related acute myeloid leukaemia (t-AML). Median age at t-AML diagnosis was 56 years, with a prior history of haematological (45%) or breast (34%). Median time from cytotoxic exposure to t-AML diagnosis was 54.7 months. At transplant, around 20% of patients had measurable residual disease and 3% of patients were not in complete remission. The median follow-up was 21...
August 31, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37653053/pulmonary-function-and-long-term-survival-in-patients-with-perds-after-autologous-hematopoietic-stem-cell-transplantation
#16
LETTER
Zhenmei Zhang, Patrick M Wieruszewski, Mehrdad Hefazi Torghabeh, William J Hogan, Hemang Yadav
No abstract text is available yet for this article.
August 31, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37644136/dexamethasone-palmitate-as-an-etoposide-free-treatment-for-children-with-hemophagocytic-lymphohistiocytosis-after-hematopoietic-cell-transplantation
#17
LETTER
Rintaro Ono, Kenichi Sakamoto, Takehiko Doi, Ryu Yanagisawa, Akira Morimoto, Hirokazu Kanegane, Yozo Nakazawa, Yoko Shioda
No abstract text is available yet for this article.
August 29, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37640797/autologous-stem-cell-transplantation-in-adult-patients-with-intermediate-risk-acute-myeloid-leukemia-in-first-complete-remission-and-no-detectable-minimal-residual-disease-a-comparative-retrospective-study-with-haploidentical-transplants-of-the-global-committee
#18
JOURNAL ARTICLE
Jia Chen, Myriam Labopin, Thomas Pabst, Xi Zhang, Erlie Jiang, Alessandra Tucci, Jan Cornelissen, Ellen Meijer, Irma Khevelidze, Emmanuelle Polge, Depei Wu, Mohamad Mohty, Norbert-Claude Gorin
In patients with acute myeloid leukemia (AML) of intermediate-risk (IR) in first remission (CR1) with no measurable residual disease (MRD negative), the choice of the best consolidation is questionable. 1122 adult patients from 196 centers, transplanted in 2010-21 were analyzed: 547 received an autologous stem cell transplantation (ASCT) and 575 a Haploidentical donor transplant. Because of a significant interaction, comparisons were done separately for patients with wild-type FLT3 (FLT3-wt) and FLT3-ITD mutation (FLT3-ITD)...
August 28, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37634015/psychosocial-assessment-practices-for-hematopoietic-stem-cell-transplantation-a-national-survey-study
#19
JOURNAL ARTICLE
Lori Wiener, Timothy S Sannes, Jill Randall, Sheila Lahijana, Allison J Applebaum, Tamryn F Gray, Natalie S McAndrew, Benjamin W Brewer, Hermioni L Amonoo
Psychosocial health predicts and contributes to medical outcomes for patients undergoing hematopoietic stem cell transplantation (HSCT). Yet, there are no standards for psychosocial assessments or support for both patients and caregivers across the care continuum. To examine the current state of psychosocial care, clinicians were sent a survey of their psychosocial assessment practices for patients and caregivers undergoing HSCT via the Listservs of professional organizations. Descriptive statistics and bivariate analyses were performed to summarize the findings...
August 26, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/37626267/evaluation-of-venous-thromboembolism-prophylaxis-protocol-in-hematopoietic-cell-transplant-patients
#20
JOURNAL ARTICLE
Angela Lee, Corinne Badgley, Mimi Lo, Marisela Tan Banez, Larissa Graff, Lloyd Damon, Thomas Martin, John Dzundza, Melisa Wong, Rebecca Olin
Hematopoietic cell transplant (HCT) recipients are at risk for thromboembolic and bleeding complications. There is limited evidence regarding the optimal approach to managing venous thromboembolism (VTE) prophylaxis in hospitalized patients undergoing HCT. In this retrospective cohort study, we evaluated the incidence of bleeding and VTE events in hospitalized HCT patients who received VTE prophylaxis per our institution's VTE Prophylaxis Protocol (VPP), with either enoxaparin 40 mg subcutaneously daily or heparin 5 000 units subcutaneously twice daily, compared to historical controls who did not receive VTE prophylaxis...
August 25, 2023: Bone Marrow Transplantation
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