We have located links that may give you full text access.
English Abstract
Journal Article
Research Support, Non-U.S. Gov't
[The role tumor necrosis factor in multiple organ dysfunction caused by bowel ischemia and reperfusion].
To explore the role of tumor necrosis factor (TNF) in the pathogenesis of multiple organ dysfunction following bowel ischemia and reperfusion, 98 rats were subjected to occlusion of the superior mesenteric artery for 45 minutes. It was found that the plasma TNF level increased rapidly after release of the clamp, peaking to 27.59 +/- 11.13 ng/ml 2 hours after reperfusion. Its changes in quantity was directly related to endotoxin in the portal circulation. Furthermore, the results showed that pretreatment with monoclonal antibody to TNF-alpha could significantly lowered the plasma TNF content and notably improved the functions of various organs. This study demonstrated that release of TNF might result in systemic hypotension and remarkable damage to liver, kidneys and lungs, which contributed to the development of sepsis and multiple system organ failure following severe ischemia-reperfusion injury of the intestine.
Full text links
Related Resources
Trending Papers
British Society of Gastroenterology guidelines for the management of hepatocellular carcinoma in adults.Gut 2024 April 17
Systemic lupus erythematosus.Lancet 2024 April 18
Should renin-angiotensin system inhibitors be held prior to major surgery?British Journal of Anaesthesia 2024 May
Ventilator Waveforms May Give Clues to Expiratory Muscle Activity.American Journal of Respiratory and Critical Care Medicine 2024 April 25
Acute Kidney Injury and Electrolyte Imbalances Caused by Dapagliflozin Short-Term Use.Pharmaceuticals 2024 March 27
Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.Endoscopy 2024 April 27
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app