We have located open access text paper links.
Exploring the Two-Way Link Between Migraines and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.
Thrombosis and Haemostasis 2024 April 25
BACKGROUND: The objective of this study is to utilize Mendelian Randomization to scrutinize the mutual causality between migraine and Venous Thromboembolism (VTE) thereby addressing the heterogeneity and inconsistency that were observed in prior observational studies concerning the potential interrelation of the two conditions.
METHODS: Employing a bidirectional Mendelian Randomization approach, the study explored the link between migraine and VTE, incorporating participants of European descent from a large-scale meta-analysis. An inverse-variance weighted (IVW) regression model, with random-effects, leveraging Single-Nucleotide Polymorphisms (SNPs) as instrumental variables was utilized to endorse the mutual causality between migraine and VTE. SNP heterogeneity was evaluated using Cochran's Q-test and to account for multiple testing, correction was implemented using the intercept of the MR-Egger method, and a leave-one-out analysis.
RESULTS: The IVW model unveiled a statistically considerable causal link between migraine and the development of VTE (odds ratio [OR] = 96.155, 95% confidence interval [CI]: 4.342-2129.458, P = 0.004), implying that migraine poses a strong-risk factor for VTE development. Conversely, both IVW and simple model outcomes indicated that VTE poses as a weaker-risk factor for migraine (IVW OR = 1.002, 95% CI: 1.000-1.004, P = 0.016). The MR-Egger regression analysis denoted absence of evidence for genetic pleiotropy among the SNPs while the durability of our Mendelian Randomization results was vouched by the leave-one-out sensitivity analysis.
CONCLUSION: The findings of this Mendelian Randomization assessment provide substantiation for a reciprocal causative association between migraine and VTE within the European population.
METHODS: Employing a bidirectional Mendelian Randomization approach, the study explored the link between migraine and VTE, incorporating participants of European descent from a large-scale meta-analysis. An inverse-variance weighted (IVW) regression model, with random-effects, leveraging Single-Nucleotide Polymorphisms (SNPs) as instrumental variables was utilized to endorse the mutual causality between migraine and VTE. SNP heterogeneity was evaluated using Cochran's Q-test and to account for multiple testing, correction was implemented using the intercept of the MR-Egger method, and a leave-one-out analysis.
RESULTS: The IVW model unveiled a statistically considerable causal link between migraine and the development of VTE (odds ratio [OR] = 96.155, 95% confidence interval [CI]: 4.342-2129.458, P = 0.004), implying that migraine poses a strong-risk factor for VTE development. Conversely, both IVW and simple model outcomes indicated that VTE poses as a weaker-risk factor for migraine (IVW OR = 1.002, 95% CI: 1.000-1.004, P = 0.016). The MR-Egger regression analysis denoted absence of evidence for genetic pleiotropy among the SNPs while the durability of our Mendelian Randomization results was vouched by the leave-one-out sensitivity analysis.
CONCLUSION: The findings of this Mendelian Randomization assessment provide substantiation for a reciprocal causative association between migraine and VTE within the European population.
Full text links
Related Resources
Trending Papers
Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.International Journal of Molecular Sciences 2024 April 13
Executive Summary: State-of-the-Art Review: Unintended Consequences: Risk of Opportunistic Infections Associated with Long-term Glucocorticoid Therapies in Adults.Clinical Infectious Diseases 2024 April 11
Clinical practice guidelines on the management of status epilepticus in adults: A systematic review.Epilepsia 2024 April 13
Finerenone: From the Mechanism of Action to Clinical Use in Kidney Disease.Pharmaceuticals 2024 March 27
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app