Benhui Liang, Lihuang Zha, Baohua Peng, Qin Chen, Mukamengjiang Juaiti, Xiaofang Zeng, Yilu Feng, Zaixin Yu, Yiyang Tang
BACKGROUND: The Life's Essential 8 (LE8) score, recently proposed by the American Heart Association, represents a new paradigm for evaluating cardiovascular health (CVH). We aimed to explore the association between CVH, estimated using LE8, and venous thromboembolism (VTE) incidence. METHODS: A total of 275,149 participants were recruited from the UK Biobank and divided into high (LE8 score ≥ 80), moderate (LE8 score < 80 but ≥50), and low (LE8 score < 50) CVH groups...
April 12, 2024: Thrombosis and Haemostasis
Sang Hyun Kim, Sanghoon Shin, Eun Ho Choo, Ik Jun Choi, Sungmin Lim, Donggyu Moon, Chan Joon Kim, Mahn-Won Park, Min Chul Kim, Byung-Hee Hwang, Kwan Yong Lee, Yun-Seok Choi, Hee-Yeol Kim, Ki-Dong Yoo, Doo Soo Jeon, Youngkeun Ahn, Kiyuk Chang
BACKGROUND: Dyspnoea is frequent during ticagrelor-based dual antiplatelet therapy (DAPT) for acute myocardial infarction (AMI). However, its clinical characteristics or management strategy remains uncertain. METHODS: The study assessed 2,617 AMI patients from the Ticagrelor versus Clopidogrel in Stabilized Patients with AMI (TALOS-AMI) trial. Dyspnoea during 1-month ticagrelor-based DAPT and following DAPT strategies with continued ticagrelor or de-escalation to clopidogrel from 1 to 12 months were evaluated for drug adherence, subsequent dyspnoea, major adverse cardiovascular events (MACE), and bleeding events...
April 4, 2024: Thrombosis and Haemostasis
Vasiliki Danilatou, Dimitris Dimopoulos, Theodoros Kostoulas, James Douketis
BACKGROUND: Venous thromboembolism (VTE) is a chronic disorder with a significant health and economic burden. Several VTE-specific Clinical Prediction Models (CPMs) have been used to assist physicians in decision-making but have several limitations. This systematic review explores if machine learning (ML) can enhance CPMs by analyzing extensive patient data derived from electronic health records (EHRs). We aimed to explore ML-CPMs applications in VTE for risk stratification, outcome prediction, diagnosis, and treatment...
April 4, 2024: Thrombosis and Haemostasis
Florian Doldi, Nele Geßler, Omar Anwar, Ann-Kathrin Kahle, Katharina Scherschel, Benjamin Rath, Julia Köbe, Philipp Sebastian Lange, Gerrit Frommeyer, Andreas Metzner, Christian Meyer, Stephan Willems, Karl-Heinz Kuck, Lars Eckardt
OBJECTIVE AND BACKGROUND:  Data on incidence of in-hospital pulmonary embolisms (PE) after catheter ablation (CA) are scarce. To gain further insights, we sought to provide new findings through case-based analyses of administrative data. METHODS:  Incidences of PE after CA of supraventricular tachycardias (SVT), atrial fibrillation (AF), atrial flutter (AFlu), and ventricular tachycardias (VT) in three German tertiary centers between 2005 and 2020 were determined and coded by the G-DRG (German Diagnosis Related Groups System) and OPS (German Operation and Procedure Classification) systems...
March 31, 2024: Thrombosis and Haemostasis
Hongmei Zhu, Richard L Auten, Augustus Richard Whorton, Stanley Nicholas Mason, Cheryl B Bock, Gary T Kucera, Zachary T Kelleher, Aaron T Vose, Tim J McMahon
BACKGROUND:  Increased adhesivity of red blood cells (RBCs) to endothelial cells (ECs) may contribute to organ dysfunction in malaria, sickle cell disease, and diabetes. RBCs normally export nitric oxide (NO)-derived vascular signals, facilitating blood flow. S-nitrosothiols (SNOs) are thiol adducts formed in RBCs from precursor NO upon the oxygenation-linked allosteric transition in hemoglobin. RBCs export these vasoregulatory SNOs on demand, thereby regulating regional blood flow and preventing RBC-EC adhesion, and the large (system L) neutral amino acid transporter 1 (LAT1; SLC7A5) appears to mediate SNO export by RBCs...
March 22, 2024: Thrombosis and Haemostasis
Luis Ortega-Paz, Francesco Franchi, Dominick J Angiolillo
No abstract text is available yet for this article.
March 19, 2024: Thrombosis and Haemostasis
Dong-Seon Kang, Pil-Sung Yang, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jung Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y H Lip, Boyoung Joung
BACKGROUND:  This study aimed to evaluate racial differences in bleeding incidence by conducting an ecological epidemiological study using data from Korea and the United Kingdom. METHODS:  We included healthy participants from the Korean National Health Insurance Service-Health Screening and the UK Biobank who underwent health examinations between 2006 and 2010 and had no comorbidities or history of medication use. Finally, 112,750 East Asians (50...
March 8, 2024: Thrombosis and Haemostasis
Dongseon Kang, Pil-Sung Yang, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jung Hoon Sung, Hui-Nam Park, Moon-Hyoung Lee, Gregory Yh Lip, Boyoug Joung
BACKGROUND: This study aimed to evaluate racial differences in the incidence of stroke by conducting an ecological epidemiological study using UK Biobank and Korean nationwide data. METHODS: This study used patient-level data from the Korean National Health Insurance Service-Health Screening and UK Biobank, which included participants who underwent health examinations between 2006 and 2010. We included 112,750 East Asians (50.7% men, mean age 52.6 years) and 210,995 Caucasians (44...
February 29, 2024: Thrombosis and Haemostasis
Hong-Cheng Du, Yun-Fei Zheng, Meng-Qi Shen, Bai-Yang Deng
BACKGROUND:  Given the current debate in clinical research about the relationship between tobacco smoking and the risk of venous thromboembolism (VTE), a Mendelian randomization (MR) study was conducted aimed at elucidating the causal associations of current and past tobacco smoking with the risk of VTE, from the perspective of genetics. METHODS:  Two-sample univariate and multivariable MR analyses were designed, using summary-level data from large genome-wide association studies involving European individuals...
February 22, 2024: Thrombosis and Haemostasis
Nanxi Li, Ruolin Hao, Peng Ren, Jingya Wang, Jiahui Dong, Tong Ye, Danyang Zhao, Xuan Qiao, Zhiyun Meng, Hui Gan, Shuchen Liu, Yunbo Sun, Guifang Dou, Ruolan Gu
Sepsis represents a syndromic response to infection and frequently acts as a common pathway leading to fatality in the context of various infectious diseases globally. The pathology of severe sepsis is marked by an excess of inflammation and activated coagulation. A substantial contributor to mortality in sepsis patients is widespread microvascular thrombosis-induced organ dysfunction. Multiple lines of evidence support the notion that sepsis induces endothelial damage, leading to the release of glycosaminoglycans, potentially causing microvascular dysfunction...
February 15, 2024: Thrombosis and Haemostasis
Zhengran Li, Minghui Zeng, Tong Wu, Zijin Wang, Yuxin Sun, Ziran Zhang, Fanye Wu, Zejun Chen, Fangke Meng, Min Fu
BACKGROUND: COVID-19 and thrombosis are linked, but the biomolecular mechanism is unclear. We aimed to investigate the causal relationship between COVID-19 and thrombotic biomarkers. METHODS: We used Two-sample Mendelian Randomization (MR) to assess the effect of COVID-19 on 20 thrombotic biomarkers. We estimated causality using Inverse variance weighting with multiplicative random effect, and performed sensitivity analysis using weighted median, MR Egger regression and MR pleiotropy residual sum and outlier (MR-PRESSO) methods...
February 7, 2024: Thrombosis and Haemostasis
Hu Hu, Xiaoyan Chen, Jingke Li, Pu Liu, Yangfan Zhou, Tongtong Zhang, Li Li, Jingqi Shi, Xin Deng, Yilin Sheng, Wei Chen, Di Wang
Introduction Platelets bridge thrombosis and inflammation, but how platelets use the endogenous intraplatelet inflammatory machinery is less well understood. NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) is best known as the central component of the interleukin (IL)-1-producing inflammasome. Unveiling a cell type-specific mechanism of NLRP3 in platelets may improve our understanding of thrombotic diseases. Methods Ferric chloride-induced mesenteric arteriole thrombosis, tail bleeding models and microfluidic whole-blood perfusion were used to assess thrombosis and hemostasis...
February 7, 2024: Thrombosis and Haemostasis
Nicola Potere, Yugo Yamashita, Walter Ageno
No abstract text is available yet for this article.
February 7, 2024: Thrombosis and Haemostasis
Job Harenberg, Robert Charles Gosselin, Adam Cuker, Cecilia Becattini, Ingrid Pabinger, Sven Poli, Jeffrey Ian Weitz, Walter Ageno, Rupert Bauersachs, Ivana Ćelap, Philip Choi, James Douketis, Jonathan Douxfils, Ismail Elalamy, Jawed Fareed, Anna Falanga, Emmanuel Favalor, Grigoris T Gerotziafas, Harald Herkner, Svetlana Hetjens, Robert Klamroth, Lars Heubner, Florian Langer, Gregory Yh Lip, Brain Mac Grory, Sandra Margetić, Anne Merrelaar, Marika Pikta, Thomas Renne', Michael Schwameis, Sam Schulman, Daniel Strbian, Alfonso Tafur, Francesco Violi, Julie Vassart, Jeanine Walenga, Christel Weiss
With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and rapid determination of DOAC levels would guide medical decision-making to (a) determine the potential contribution of the DOAC to spontaneous or trauma-induced hemorrhage; (b) identify appropriate candidates for reversal, or (c) optimize the timing of urgent surgery or intervention. The DOAC Dipstick test uses a disposable strip to identify factor Xa- or thrombin inhibitors in a urine sample...
February 5, 2024: Thrombosis and Haemostasis
Alexander Cohen, Christopher Wallenhorst, Marcela Rivera, Cihan Ay, Bernhard Schaefer, Khaled Abdelgawwad, George Psaroudakis, Gunnar Brobert, Anders Ekbom, Agnes Y Y Lee, Alok A Khorana, Cecilia Becattini, Marc Carrier, Craig I Coleman, Carlos Martinez
BACKGROUND: In most patients with cancer-associated venous thromboembolism (CAT), essentially those not at high-risk of bleeding, guidelines recommend treatment with direct oral anticoagulants as an alternative to low molecular weight heparins (LMWHs). Population-based studies comparing these therapies are scarce. OBJECTIVES: To compare the risk of venous thromboembolism (VTE) recurrences, significant bleeding and all-cause mortality in patients with CAT, receiving rivaroxaban or LMWHs...
February 1, 2024: Thrombosis and Haemostasis
Noritaka Yada, Quan Zhang, Antonia Bignotti, Zhan Ye, X Long Zheng
BACKGROUND: Neutrophil NETosis and neutrophil extracellular traps (NETs) play a critical role in pathogenesis of COVID-19 associated thrombosis. However, the extents and reserve of NETosis, and potential of thrombus formation under shear in whole blood of patients with COVID-19 are not fully elucidated. Neither has the role of recombinant ADAMTS13 or caplacizumab on the accumulation of NETs and thrombus in COVID-19 patients' whole blood under shear been investigated. METHODS: Flow cytometry and microfluidic assay, as well as immunoassays were employed for the study...
January 25, 2024: Thrombosis and Haemostasis
Lucia Rugeri, William Thomas, Kathrin Schirner, Lisa Heyder, Günter Auerswald
BACKGROUND: For the treatment of von Willebrand disease (VWD), von Willebrand Factor (VWF) concentrates can be used in on-demand, long-term prophylaxis and surgical prophylaxis regimens. METHODS: This systematic literature review was conducted to evaluate the efficacy, consumption and safety of plasma-derived human coagulation FVIII/human VWF (pdVWF/FVIII; Voncento®/Biostate®) for the treatment of patients with any inherited VWD type. An electronic search was conducted in MEDLINE® and Cochrane Library databases on VWD therapies...
January 25, 2024: Thrombosis and Haemostasis
Takeshi Wada, Satoshi Gando
Two phenotypes of disseminated intravascular coagulation (DIC) are systematically reviewed. DIC is classified into thrombotic and fibrinolytic phenotypes characterized by thrombosis and hemorrhage, respectively. Major pathology of DIC with thrombotic phenotype is the activation of coagulation, insufficient anticoagulation with endothelial injury, and plasminogen activator inhibitor-1-mediated inhibition of fibrinolysis, leading to microvascular fibrin thrombosis and organ dysfunction. DIC with fibrinolytic phenotype is defined as massive thrombin generation commonly observed in any type of DIC, combined with systemic pathologic hyperfibrinogenolysis caused by underlying disorder that results in severe bleeding due to excessive plasmin formation...
March 2024: Thrombosis and Haemostasis
Bernadette Corica, Giulio Francesco Romiti, Marco Proietti
No abstract text is available yet for this article.
February 2024: Thrombosis and Haemostasis
Luís Duarte-Gamas, Filipa Jácome, Lara Romana Dias, João Rocha-Neves, Kak K Yeung, Niels Baekgaard, Marina Dias-Neto
OBJECTIVE:  To summarize characteristics, complications, and success rates of different catheter-directed thrombolysis (CDT) protocols for the treatment of lower extremity deep venous thrombosis (LE-DVT). METHODS:  A systematic review using electronic databases (MEDLINE, Scopus, and Web of Science) was performed to identify randomized controlled trials and observational studies related to LE-DVT treated with CDT. A random-effects model meta-analysis was performed to obtain the pooled proportions of early complications, postthrombotic syndrome (PTS), and venous patency...
February 2024: Thrombosis and Haemostasis
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